X1 Ensembl ID HGNC symbol DBD Is TF? TF assessment Binding mode Motif status Final Notes Final Comments Interpro ID(s) EntrezGene ID EntrezGene Description PDB ID TF tested by HT-SELEX? TF tested by PBM? Conditional Binding Requirements Original Comments Vaquerizas 2009 classification CisBP considers it a TF? TFCat classification Is a GO TF? Initial assessment Curator 1 Curator 2 TFclass considers it a TF? Go Evidence Pfam Domains (By ENSP ID) Is C2H2 ZF(KRAB)? 0 ENSG00000137203 TFAP2A AP-2 Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR008121;IPR013854 7020 transcription factor AP-2 alpha [Source:HGNC Symbol;Acc:HGNC:11742] None DBD Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:11522791;15475956 Yes 1a1, Direct HQ evidence Sam Lambert Yimeng Yin Yes $#ENSG00000137203#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IDA - PMID:7555706$#ENSG00000137203#GO:0000982#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:21084835$#ENSG00000137203#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:11278550, PMID:20808827$#ENSG00000137203#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:11278550, PMID:20066163, PMID:9520389 $#ENSP00000368928#ENSG00000137203#ENST00000379608#AP-2#$#ENSP00000368933#ENSG00000137203#ENST00000379613#AP-2#$#ENSP00000417495#ENSG00000137203#ENST00000466073#AP-2#$#ENSP00000417735#ENSG00000137203#ENST00000461628#AP-2#$#ENSP00000418391#ENSG00000137203#ENST00000465858#AP-2#$#ENSP00000419696#ENSG00000137203#ENST00000475264#AP-2# FALSE 1 ENSG00000008196 TFAP2B AP-2 Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR008122;IPR013854 7021 transcription factor AP-2 beta [Source:HGNC Symbol;Acc:HGNC:11743] None DBD Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:7555706 Yes 1a1, Direct HQ evidence Matt Weirauch Yimeng Yin Yes $#ENSG00000008196#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IDA - PMID:7555706$#ENSG00000008196#GO:0000983#RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024$#ENSG00000008196#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000008196#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:11505339, PMID:12169688, PMID:16373396 $#ENSP00000377265#ENSG00000008196#ENST00000393655#AP-2#$#ENSP00000342252#ENSG00000008196#ENST00000344788#AP-2# FALSE 2 ENSG00000087510 TFAP2C AP-2 Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR008123;IPR013854 7022 transcription factor AP-2 gamma [Source:HGNC Symbol;Acc:HGNC:11744] None DBD and Full Yes None None a Yes No Yes 1a1, Direct HQ evidence Matt Weirauch Yimeng Yin Yes $#ENSG00000087510#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:11278550$#ENSG00000087510#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:11278550$#ENSG00000087510#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:9113991 $#ENSP00000201031#ENSG00000087510#ENST00000201031#AP-2#$#ENSP00000390857#ENSG00000087510#ENST00000416606#AP-2# FALSE 3 ENSG00000008197 TFAP2D AP-2 Yes Known motif Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain Binds the same GCCTGAGGC sequence as the other AP-2s (PMID: 24789576) IPR013854; 83741 transcription factor AP-2 delta [Source:HGNC Symbol;Acc:HGNC:15581] None not tested not tested None None a Yes No Yes 2a1, Lower confidence direct evidence Arttu Jolma Sam Lambert Yes $#ENSG00000008197#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000008391#ENSG00000008197#ENST00000008391#AP-2# FALSE 4 ENSG00000116819 TFAP2E AP-2 Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR013854; 339488 transcription factor AP-2 epsilon [Source:HGNC Symbol;Acc:HGNC:30774] None Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:14572467 Yes 1a1, Direct HQ evidence Sam Lambert Laura Campitelli Yes $#ENSG00000116819#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000116819#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019 $#ENSP00000362332#ENSG00000116819#ENST00000373235#AP-2# FALSE 5 ENSG00000117713 ARID1A ARID/BRIGHT No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None Non-specific DNA binder (PMID: 15170388). IPR001606;IPR016024;IPR021906; 8289 AT-rich interaction domain 1A [Source:HGNC Symbol;Acc:HGNC:11110] None not tested Yes None Chromatin_Modifier_etc No Yes TF Gene_DNA-Binding: non-sequence-specific_Non-specific DNA_PMIDS:15170388 No 4a, two or more datasets predict it as a TF Matt Weirauch Pratyush Das No None $#ENSP00000320485#ENSG00000117713#ENST00000324856#ARID/BRIGHT#BAF250_C$#ENSP00000390317#ENSG00000117713#ENST00000430799#ARID/BRIGHT#BAF250_C$#ENSP00000489842#ENSG00000117713#ENST00000636219#ARID/BRIGHT#BAF250_C$#ENSP00000490650#ENSG00000117713#ENST00000637465#ARID/BRIGHT# FALSE 6 ENSG00000049618 ARID1B ARID/BRIGHT No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None Non-specific DNA binder (PMID: 15170388). IPR001606;IPR021906 57492 AT-rich interaction domain 1B [Source:HGNC Symbol;Acc:HGNC:18040] None not tested Yes None Chromatin_Modifier_etc No Yes TF Gene_Transcription Factor Binding: tf co-factor binding; DNA-Binding: non-sequence-specific; Transcription Regulatory Activity: heterochromatin interaction/binding_TF PPI_PMIDS:12200431;15170388 No 4a, two or more datasets predict it as a TF Matt Weirauch Jussi Taipale Yes None $#ENSP00000344546#ENSG00000049618#ENST00000346085#ARID/BRIGHT#BAF250_C$#ENSP00000055163#ENSG00000049618#ENST00000350026#ARID/BRIGHT#BAF250_C$#ENSP00000313006#ENSG00000049618#ENST00000319584#ARID/BRIGHT#$#ENSP00000383596#ENSG00000049618#ENST00000400790#ARID/BRIGHT#$#ENSP00000490948#ENSG00000049618#ENST00000635849#ARID/BRIGHT#BAF250_C$#ENSP00000489717#ENSG00000049618#ENST00000635928#ARID/BRIGHT#BAF250_C$#ENSP00000490385#ENSG00000049618#ENST00000635957#ARID/BRIGHT#BAF250_C$#ENSP00000490050#ENSG00000049618#ENST00000636607#ARID/BRIGHT#$#ENSP00000489917#ENSG00000049618#ENST00000636748#ARID/BRIGHT#$#ENSP00000490491#ENSG00000049618#ENST00000636930#ARID/BRIGHT#BAF250_C$#ENSP00000489666#ENSG00000049618#ENST00000637003#ARID/BRIGHT#$#ENSP00000489729#ENSG00000049618#ENST00000637015#ARID/BRIGHT#BAF250_C$#ENSP00000490420#ENSG00000049618#ENST00000637532#ARID/BRIGHT#$#ENSP00000489636#ENSG00000049618#ENST00000637810#ARID/BRIGHT#BAF250_C$#ENSP00000490944#ENSG00000049618#ENST00000637887#ARID/BRIGHT#$#ENSP00000490550#ENSG00000049618#ENST00000637904#ARID/BRIGHT#BAF250_C$#ENSP00000489982#ENSG00000049618#ENST00000638000#ARID/BRIGHT# FALSE 7 ENSG00000116017 ARID3A ARID/BRIGHT Yes Known motif Monomer or homomultimer 100 perc ID - in vitro None None IPR001606;IPR023334 1820 AT-rich interaction domain 3A [Source:HGNC Symbol;Acc:HGNC:3031] None not tested Yes None None other Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:15456761 Yes 1a1, Direct HQ evidence Sam Lambert Arttu Jolma Yes $#ENSG00000116017#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IBA - GO_REF:0000033 $#ENSP00000263620#ENSG00000116017#ENST00000263620#ARID/BRIGHT#$#ENSP00000464969#ENSG00000116017#ENST00000587532#ARID/BRIGHT# FALSE 8 ENSG00000179361 ARID3B ARID/BRIGHT Yes Inferred motif Monomer or homomultimer High-throughput in vitro None None IPR001606;IPR023334 10620 AT-rich interaction domain 3B [Source:HGNC Symbol;Acc:HGNC:14350] None not tested Yes None TFs that are in CisBP but not in Vaquerizas set No Yes TF Gene Candidate_Transcription Factor Binding: tf co-factor binding; DNA-Binding: non-sequence-specific_DNA Binding; TF PPI_PMIDS:10446990 Yes 1a1, Direct HQ evidence Yimeng Yin Pratyush Das Yes $#ENSG00000179361#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000179361#GO:0001205#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involv#IEA - GO_REF:0000019$#ENSG00000179361#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IBA - GO_REF:0000033 $#ENSP00000343126#ENSG00000179361#ENST00000346246#ARID/BRIGHT#$#ENSP00000477878#ENSG00000179361#ENST00000622429#ARID/BRIGHT#$#ENSP00000455668#ENSG00000179361#ENST00000566147#ARID/BRIGHT# FALSE 9 ENSG00000205143 ARID3C ARID/BRIGHT Yes Inferred motif Monomer or homomultimer High-throughput in vitro None None IPR001606;IPR023334 138715 AT-rich interaction domain 3C [Source:HGNC Symbol;Acc:HGNC:21209] None not tested Yes None None No Yes Indeterminate - There is no evidence for or against this genes role as a TF__Other_PMIDS:15922553 Yes 1a2, Orthologous HQ evidence Yimeng Yin Pratyush Das Yes $#ENSG00000205143#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IBA - GO_REF:0000033 $#ENSP00000368189#ENSG00000205143#ENST00000378909#ARID/BRIGHT# FALSE 10 ENSG00000032219 ARID4A ARID/BRIGHT No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif Has a putative AT-hook Binds DNA in a sequence non-specific manner (PMID: 15640446). IPR000953;IPR001606;IPR002999;IPR012603;IPR016197;IPR025995 5926 AT-rich interaction domain 4A [Source:HGNC Symbol;Acc:HGNC:9885] None not tested Yes None Chromatin_Modifier_etc No Yes TF Gene_Transcription Regulatory Activity: heterochromatin interaction/binding; Transcription Factor Binding: tf co-factor binding_Other; TF PPI_PMIDS:10321733;10490602 Yes 4a, two or more datasets predict it as a TF Tim Hughes Yimeng Yin Yes $#ENSG00000032219#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:8414517 $#ENSP00000347602#ENSG00000032219#ENST00000355431#ARID/BRIGHT#RBB1NT, Tudor-knot$#ENSP00000416053#ENSG00000032219#ENST00000417477#ARID/BRIGHT#Tudor-knot$#ENSP00000415872#ENSG00000032219#ENST00000424658#ARID/BRIGHT#$#ENSP00000392567#ENSG00000032219#ENST00000445108#ARID/BRIGHT#PWWP, RBB1NT FALSE 11 ENSG00000054267 ARID4B ARID/BRIGHT No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None Binds DNA in a sequence non-specific manner (PMID: 15640446). IPR001606;IPR002999;IPR012603;IPR016197;IPR025995; 51742 AT-rich interaction domain 4B [Source:HGNC Symbol;Acc:HGNC:15550] None not tested Yes None Chromatin_Modifier_etc No Yes TF Gene_Transcription Regulatory Activity: heterochromatin interaction/binding_Co-activation; TF PPI_PMIDS:12724404 No 4a, two or more datasets predict it as a TF Jussi Taipale Yimeng Yin Yes None $#ENSP00000264183#ENSG00000054267#ENST00000264183#ARID/BRIGHT#PWWP, RBB1NT, Tudor-knot$#ENSP00000264184#ENSG00000054267#ENST00000349213#ARID/BRIGHT#RBB1NT$#ENSP00000355562#ENSG00000054267#ENST00000366603#ARID/BRIGHT#PWWP, RBB1NT, Tudor-knot FALSE 12 ENSG00000196843 ARID5A ARID/BRIGHT Yes Known motif Monomer or homomultimer 100 perc ID - in vitro None None IPR001606; 10865 AT-rich interaction domain 5A [Source:HGNC Symbol;Acc:HGNC:17361] None not tested Yes None TFs that are in CisBP but not in Vaquerizas set No Yes Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0 No 1a1, Direct HQ evidence Sam Lambert Laura Campitelli Yes None $#ENSP00000350078#ENSG00000196843#ENST00000357485#ARID/BRIGHT#$#ENSP00000400785#ENSG00000196843#ENST00000454558#ARID/BRIGHT# FALSE 13 ENSG00000150347 ARID5B ARID/BRIGHT Yes Known motif Monomer or homomultimer 100 perc ID - in vitro Has a putative AT-hook None IPR001606; 84159 AT-rich interaction domain 5B [Source:HGNC Symbol;Acc:HGNC:17362] 2OEH not tested Yes None None other Yes TF Gene Candidate_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:8649988;10329386 Yes 1a1, Direct HQ evidence Arttu Jolma Yimeng Yin Yes $#ENSG00000150347#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IDA - PMID:8649988$#ENSG00000150347#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:21532585 $#ENSP00000279873#ENSG00000150347#ENST00000279873#ARID/BRIGHT#$#ENSP00000308862#ENSG00000150347#ENST00000309334#ARID/BRIGHT# FALSE 14 ENSG00000008083 JARID2 ARID/BRIGHT No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None Only ARID3 and ARID5 family members have sequence specificity (PMID: 15640446). IPR001606;IPR003347;IPR003349;IPR004198 3720 jumonji and AT-rich interaction domain containing 2 [Source:HGNC Symbol;Acc:HGNC:6196] None not tested Yes None Chromatin_Modifier_etc No Yes No No 4a, two or more datasets predict it as a TF Pratyush Das Tim Hughes Yes $#ENSG00000008083#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IEA - GO_REF:0000019 $#ENSP00000341280#ENSG00000008083#ENST00000341776#ARID/BRIGHT#JmjC, JmjN, zf-C5HC2$#ENSP00000380478#ENSG00000008083#ENST00000397311#ARID/BRIGHT#JmjC, JmjN, zf-C5HC2 FALSE 15 ENSG00000073614 KDM5A ARID/BRIGHT No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None None IPR001606;IPR001965;IPR003347;IPR003349;IPR004198;IPR011011;IPR013637;IPR019786;IPR019787; 5927 lysine demethylase 5A [Source:HGNC Symbol;Acc:HGNC:9886] None not tested not tested None Chromatin_Modifier_etc No Yes TF Gene_Transcription Factor Binding: tf co-factor binding_Co-activation; TF PPI_PMIDS:9129143;11358960;15949438 Yes 4a, two or more datasets predict it as a TF Sam Lambert Jussi Taipale Yes $#ENSG00000073614#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:8414517 $#ENSP00000382688#ENSG00000073614#ENST00000399788#ARID/BRIGHT#JmjC, JmjN, PHD, PLU-1, zf-C5HC2$#ENSP00000440622#ENSG00000073614#ENST00000544760#ARID/BRIGHT#JmjC, JmjN, PLU-1, zf-C5HC2 FALSE 16 ENSG00000117139 KDM5B ARID/BRIGHT Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Binds GC-rich sequences such as CCGCCC (PMID: 18270511). IPR001606;IPR001965;IPR003347;IPR003349;IPR004198;IPR011011;IPR013637;IPR019786;IPR019787; 10765 lysine demethylase 5B [Source:HGNC Symbol;Acc:HGNC:18039] None not tested not tested None Chromatin_Modifier_etc No Yes TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI; Transactivation_PMIDS:12657635 Yes 4a, two or more datasets predict it as a TF Arttu Jolma Yimeng Yin Yes $#ENSG00000117139#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:10336460 $#ENSP00000356233#ENSG00000117139#ENST00000367264#ARID/BRIGHT#JmjC, JmjN, PHD, PHD_2, PLU-1, zf-C5HC2$#ENSP00000356234#ENSG00000117139#ENST00000367265#ARID/BRIGHT#JmjC, JmjN, PHD, PHD_2, PLU-1, zf-C5HC2$#ENSP00000235790#ENSG00000117139#ENST00000235790#ARID/BRIGHT#JmjC, PHD, PHD_2, PLU-1, zf-C5HC2, zf-PHD-like FALSE 17 ENSG00000126012 KDM5C ARID/BRIGHT No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None None IPR001606;IPR001965;IPR003347;IPR003349;IPR004198;IPR011011;IPR013637;IPR019786;IPR019787; 8242 lysine demethylase 5C [Source:HGNC Symbol;Acc:HGNC:11114] None not tested not tested None Chromatin_Modifier_etc No Yes TF Gene Candidate_Transcription Regulatory Activity: heterochromatin interaction/binding_Other_PMIDS:17320160 No 4a, two or more datasets predict it as a TF Jussi Taipale Arttu Jolma Yes None $#ENSP00000364550#ENSG00000126012#ENST00000375401#ARID/BRIGHT#JmjC, JmjN, PHD, PLU-1, zf-C5HC2$#ENSP00000385394#ENSG00000126012#ENST00000404049#ARID/BRIGHT#JmjC, JmjN, PHD, PLU-1, zf-C5HC2 FALSE 18 ENSG00000012817 KDM5D ARID/BRIGHT No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None Polycomb protein that is well-documented to bind histone marks (PMID: 27477906; PMID: 17351630; PMID: 17320160; PMID: 17320162). IPR001606;IPR001965;IPR003347;IPR003349;IPR004198;IPR011011;IPR013637;IPR019786;IPR019787; 8284 lysine demethylase 5D [Source:HGNC Symbol;Acc:HGNC:11115] None not tested not tested None Chromatin_Modifier_etc No Yes Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0 No 4a, two or more datasets predict it as a TF Laura Campitelli Jussi Taipale Yes None $#ENSP00000322408#ENSG00000012817#ENST00000317961#ARID/BRIGHT#JmjC, JmjN, PHD, PLU-1, zf-C5HC2$#ENSP00000372256#ENSG00000012817#ENST00000382806#ARID/BRIGHT#JmjC, JmjN, PHD, PLU-1, zf-C5HC2$#ENSP00000444293#ENSG00000012817#ENST00000541639#ARID/BRIGHT#JmjC, JmjN, PHD, PLU-1, zf-C5HC2$#ENSP00000416377#ENSG00000012817#ENST00000447300#ARID/BRIGHT#JmjN, PHD$#ENSP00000389433#ENSG00000012817#ENST00000415360#ARID/BRIGHT#PHD, PLU-1 FALSE 19 ENSG00000189079 ARID2 ARID/BRIGHT; RFX Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR001606;IPR003150;IPR007087;IPR016024 196528 AT-rich interaction domain 2 [Source:HGNC Symbol;Acc:HGNC:18037] None not tested Yes None None x Yes TF Gene_Transcription Factor Binding: tf co-factor binding_Co-activation_PMIDS:16782067 No 1a2, Orthologous HQ evidence Pratyush Das Jussi Taipale Yes None $#ENSP00000335044#ENSG00000189079#ENST00000334344#ARID/BRIGHT, RFX#$#ENSP00000415650#ENSG00000189079#ENST00000422737#ARID/BRIGHT, RFX#$#ENSP00000397307#ENSG00000189079#ENST00000444670#ARID/BRIGHT, RFX#$#ENSP00000388357#ENSG00000189079#ENST00000457135#ARID/BRIGHT, RFX#FOXP-CC$#ENSP00000481488#ENSG00000189079#ENST00000477947#ARID/BRIGHT, RFX# FALSE 20 ENSG00000153207 AHCTF1 AT hook Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR011047;IPR025151 25909 AT-hook containing transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:24618] None not tested Yes None None c No No No 1a1, Direct HQ evidence Jussi Taipale Laura Campitelli No $#ENSG00000153207#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019 $#ENSP00000355465#ENSG00000153207#ENST00000326225#AT hook#ELYS, ELYS-bb$#ENSP00000417115#ENSG00000153207#ENST00000478568#AT hook#ELYS-bb$#ENSP00000355464#ENSG00000153207#ENST00000366508#AT hook#ELYS, ELYS-bb FALSE 21 ENSG00000126705 AHDC1 AT hook Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None None 27245 AT-hook DNA binding motif containing 1 [Source:HGNC Symbol;Acc:HGNC:25230] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Sam Lambert Laura Campitelli No None $#ENSP00000247087#ENSG00000126705#ENST00000247087#AT hook#DUF4683$#ENSP00000363123#ENSG00000126705#ENST00000374011#AT hook#DUF4683 FALSE 22 ENSG00000106948 AKNA AT hook Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Binds AT-rich promoters of CD40 and CD40L and coordinates their expression (PMID: 11268217). IPR022150; 80709 AT-hook transcription factor [Source:HGNC Symbol;Acc:HGNC:24108] None Full not tested None None c No No Yes 4a, two or more datasets predict it as a TF Tim Hughes Laura Campitelli No $#ENSG00000106948#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:11268217 $#ENSP00000303769#ENSG00000106948#ENST00000307564#AT hook#AKNA$#ENSP00000309222#ENSG00000106948#ENST00000312033#AT hook#AKNA$#ENSP00000363188#ENSG00000106948#ENST00000374075#AT hook#AKNA$#ENSP00000363192#ENSG00000106948#ENST00000374079#AT hook#$#ENSP00000223791#ENSG00000106948#ENST00000223791#AT hook#AKNA$#ENSP00000363201#ENSG00000106948#ENST00000374088#AT hook#AKNA FALSE 23 ENSG00000116539 ASH1L AT hook Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR001025;IPR001214;IPR001487;IPR001965;IPR003616;IPR006560;IPR011011;IPR017956;IPR019786;IPR019787 693140 ASH1 like histone lysine methyltransferase [Source:HGNC Symbol;Acc:HGNC:19088] None not tested not tested Chromatin_Modifier_etc None a No No No 5a, one of the source datasets predicts is as a TF Pratyush Das Arttu Jolma No None $#ENSP00000357330#ENSG00000116539#ENST00000368346#AT hook#BAH, Bromodomain, PHD, SET$#ENSP00000376204#ENSG00000116539#ENST00000392403#AT hook#BAH, Bromodomain, PHD, SET$#ENSP00000449283#ENSG00000116539#ENST00000548830#AT hook# FALSE 24 ENSG00000173894 CBX2 AT hook Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR000953;IPR016197;IPR017984;IPR023779;IPR023780; 84733 chromobox 2 [Source:HGNC Symbol;Acc:HGNC:1552] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Sam Lambert Yimeng Yin No None $#ENSP00000269399#ENSG00000173894#ENST00000269399#Other#Chromo, Tudor-knot$#ENSP00000308750#ENSG00000173894#ENST00000310942#Other#CBX7_C, Chromo FALSE 25 ENSG00000101457 DNTTIP1 AT hook Yes Likely to be sequence specific TF Monomer or homomultimer No motif Has a putative AT-hook None None 116092 deoxynucleotidyltransferase, terminal, interacting protein 1 [Source:HGNC Symbol;Acc:HGNC:16160] None not tested not tested None PMID:11473582 Terminal deoxynucleotidyltransferase (TdT) is a DNA polymerase that enhances Ig and TcR gene diversity in the N region in B- and T-cells. No No No No 2a1, Lower confidence direct evidence Yimeng Yin Arttu Jolma No None $##ENSG00000101457##Other# FALSE 26 ENSG00000104885 DOT1L AT hook Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR013110;IPR021169;IPR025789;IPR029063 84444 DOT1 like histone lysine methyltransferase [Source:HGNC Symbol;Acc:HGNC:24948] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Arttu Jolma Yimeng Yin No None $#ENSP00000381657#ENSG00000104885#ENST00000398665#Other#DOT1$#ENSP00000412916#ENSG00000104885#ENST00000446286#Other#$#ENSP00000404284#ENSG00000104885#ENST00000452696#Other#DOT1$#ENSP00000476469#ENSG00000104885#ENST00000586024#Other# FALSE 27 ENSG00000140632 GLYR1 AT hook Yes Likely to be sequence specific TF Monomer or homomultimer No motif Has a putative AT-hook None IPR000313;IPR006115;IPR008927;IPR029154 84656 glyoxylate reductase 1 homolog None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Laura Campitelli Pratyush Das No None $#ENSP00000322716#ENSG00000140632#ENST00000321919#Other#2-Hacid_dh_C, 3HCDH_N, ApbA, F420_oxidored, NAD_bi$#ENSP00000466570#ENSG00000140632#ENST00000589389#Other#2-Hacid_dh_C, 3HCDH_N, ApbA, F420_oxidored, NAD_bi$#ENSP00000468328#ENSG00000140632#ENST00000591451#Other#2-Hacid_dh_C, 3HCDH_N, F420_oxidored, NAD_binding_$#ENSP00000390276#ENSG00000140632#ENST00000436648#Other#2-Hacid_dh_C, 3HCDH_N, ApbA, F420_oxidored, NAD_bi$#ENSP00000467541#ENSG00000140632#ENST00000587297#Other#$#ENSP00000467751#ENSG00000140632#ENST00000588297#Other#PWWP FALSE 28 ENSG00000137309 HMGA1 AT hook Yes Known motif Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain None IPR000116;IPR000637;IPR017956;IPR020478 3159 high mobility group AT-hook 1 [Source:HGNC Symbol;Acc:HGNC:5010] 2EZD not tested not tested None Pmid:9253416 Architectural HMG c Yes TF Gene_DNA-Binding: non-sequence-specific; Transcription Factor Binding: tf co-factor binding_DNA Binding_PMIDS:9199299;12907668 Yes 3a, decent circumstantial evidence for its role as Yimeng Yin Arttu Jolma Yes $#ENSG00000137309#GO:0001205#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involv#ISS - GO_REF:0000024$#ENSG00000137309#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000308227#ENSG00000137309#ENST00000311487#AT hook#$#ENSP00000288245#ENSG00000137309#ENST00000347617#AT hook#$#ENSP00000363230#ENSG00000137309#ENST00000374116#AT hook#$#ENSP00000385693#ENSG00000137309#ENST00000401473#AT hook#$#ENSP00000399888#ENSG00000137309#ENST00000447654#AT hook# FALSE 29 ENSG00000149948 HMGA2 AT hook Yes Known motif Monomer or homomultimer In vivo/Misc source None None IPR000116;IPR000637;IPR017956;IPR020478 8091 high mobility group AT-hook 2 [Source:HGNC Symbol;Acc:HGNC:5009] None not tested Yes None None x Yes No Yes 1a1, Direct HQ evidence Arttu Jolma Pratyush Das Yes $#ENSG00000149948#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:18832382$#ENSG00000149948#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:14627817 $#ENSP00000346658#ENSG00000149948#ENST00000354636#AT hook#$#ENSP00000377206#ENSG00000149948#ENST00000393578#AT hook#$#ENSP00000384026#ENSG00000149948#ENST00000403681#AT hook#$#ENSP00000407306#ENSG00000149948#ENST00000425208#AT hook#$#ENSP00000437621#ENSG00000149948#ENST00000536545#AT hook#$#ENSP00000439317#ENSG00000149948#ENST00000541363#AT hook#$#ENSP00000377205#ENSG00000149948#ENST00000393577#AT hook# FALSE 30 ENSG00000025293 PHF20 AT hook Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR001965;IPR002999;IPR007087;IPR011011;IPR019786;IPR019787;IPR022255; 51230 PHD finger protein 20 [Source:HGNC Symbol;Acc:HGNC:16098] None DBD and Full not tested None None b No No No 5a, one of the source datasets predicts is as a TF Arttu Jolma Yimeng Yin No None $#ENSP00000363112#ENSG00000025293#ENST00000374000#Other#DUF3776, DUF4537, LBR_tudor, MBT, Rad9_Rad53_bind,$#ENSP00000363124#ENSG00000025293#ENST00000374012#Other#DUF1325, DUF3776, DUF4537, LBR_tudor, MBT, PHD, Ra$#ENSP00000341900#ENSG00000025293#ENST00000339089#Other#DUF1325, DUF3776, DUF4537, LBR_tudor, MBT, Rad9_Ra$#ENSP00000413712#ENSG00000025293#ENST00000420233#Other# FALSE 31 ENSG00000135365 PHF21A AT hook Yes Likely to be sequence specific TF Monomer or homomultimer No motif Has a putative AT-hook None IPR001965;IPR011011;IPR017956;IPR019786;IPR019787; 51317 PHD finger protein 21A [Source:HGNC Symbol;Acc:HGNC:24156] None not tested not tested None None x No Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0 No 1a1, Direct HQ evidence Pratyush Das Jussi Taipale No None $#ENSP00000323152#ENSG00000135365#ENST00000323180#Other#C1_1, PHD, PHD_2$#ENSP00000398824#ENSG00000135365#ENST00000418153#Other#C1_1, PHD, PHD_2, zf-HC5HC2H$#ENSP00000431621#ENSG00000135365#ENST00000532028#Other#DUF1043, DUF1664, HOOK, S6OS1 FALSE 32 ENSG00000126464 PRR12 AT hook Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR025451; 57479 proline rich 12 [Source:HGNC Symbol;Acc:HGNC:29217] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Laura Campitelli Tim Hughes No None $#ENSP00000394510#ENSG00000126464#ENST00000418929#Other#DUF4211$#ENSP00000478000#ENSG00000126464#ENST00000615927#Other#DUF4211 FALSE 33 ENSG00000146285 SCML4 AT hook Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR001660;IPR013761;IPR021129;IPR021987 256380 sex comb on midleg-like 4 (Drosophila) [Source:HGNC Symbol;Acc:HGNC:21397] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Matt Weirauch Laura Campitelli No None $#ENSP00000358021#ENSG00000146285#ENST00000369025#Other#SAM_1, SAM_2, SAM_PNT$#ENSP00000358018#ENSG00000146285#ENST00000369022#Other#SAM_1, SAM_2, SAM_PNT, SLED$#ENSP00000404688#ENSG00000146285#ENST00000440927#Other#SLED FALSE 34 ENSG00000152217 SETBP1 AT hook Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Orthologous protein from mouse (Setbp1) bind DNA sequence-specifically by PBM IPR017956; 26040 SET binding protein 1 [Source:HGNC Symbol;Acc:HGNC:15573] None not tested Yes None None c No No No 1a1, Direct HQ evidence Pratyush Das Sam Lambert No None $#ENSP00000282030#ENSG00000152217#ENST00000282030#AT hook#$#ENSP00000390687#ENSG00000152217#ENST00000426838#AT hook#$#ENSP00000468506#ENSG00000152217#ENST00000591940#AT hook# FALSE 35 ENSG00000080603 SRCAP AT hook Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR000330;IPR001650;IPR013999;IPR014001;IPR014012;IPR017956;IPR020478;IPR027417 10847 Snf2-related CREBBP activator protein [Source:HGNC Symbol;Acc:HGNC:16974] None Full not tested None None x No No No 5a, one of the source datasets predicts is as a TF Matt Weirauch Arttu Jolma No None $#ENSP00000262518#ENSG00000080603#ENST00000262518#AT hook#DEAD, HSA, Helicase_C, SNF2_N$#ENSP00000378499#ENSG00000080603#ENST00000395059#AT hook#DEAD, Helicase_C, SNF2_N$#ENSP00000483329#ENSG00000080603#ENST00000483083#AT hook#ResIII, SNF2_N$#ENSP00000405186#ENSG00000080603#ENST00000411466#AT hook# FALSE 36 ENSG00000188070 C11orf95 BED ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR015880; 65998 chromosome 11 open reading frame 95 [Source:HGNC Symbol;Acc:HGNC:28449] None not tested not tested None None x Yes No No 4a, two or more datasets predict it as a TF Sam Lambert Jussi Taipale No None $#ENSP00000483097#ENSG00000188070#ENST00000338498#BED ZF#$#ENSP00000482857#ENSG00000188070#ENST00000546282#BED ZF#$#ENSP00000482180#ENSG00000188070#ENST00000433688#BED ZF#DUF678, Trm112p$#ENSP00000478462#ENSG00000188070#ENST00000445014#BED ZF# FALSE 37 ENSG00000237765 FAM200B BED ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR012337 285550 family with sequence similarity 200 member B [Source:HGNC Symbol;Acc:HGNC:27740] None not tested not tested None None No Yes No Yes 4a, two or more datasets predict it as a TF Laura Campitelli Yimeng Yin No $#ENSG00000237765#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000393017#ENSG00000237765#ENST00000422728#BED ZF#$#ENSP00000483930#ENSG00000237765#ENST00000622362#BED ZF#$#ENSP00000422751#ENSG00000237765#ENST00000503617#BED ZF# FALSE 38 ENSG00000141258 SGSM2 BED ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR000195;IPR004012 9905 small G protein signaling modulator 2 [Source:HGNC Symbol;Acc:HGNC:29026] None not tested not tested None None No Yes No No 5a, one of the source datasets predicts is as a TF Matt Weirauch Yimeng Yin No None $#ENSP00000268989#ENSG00000141258#ENST00000268989#BED ZF#DUF3548, RUN, RabGAP-TBC$#ENSP00000415107#ENSG00000141258#ENST00000426855#BED ZF#DUF3548, RUN, RabGAP-TBC$#ENSP00000464593#ENSG00000141258#ENST00000573851#BED ZF#RabGAP-TBC$#ENSP00000459126#ENSG00000141258#ENST00000574563#BED ZF#DUF3548, RUN, RabGAP-TBC$#ENSP00000460205#ENSG00000141258#ENST00000570431#BED ZF#DUF3548$#ENSP00000461820#ENSG00000141258#ENST00000572925#BED ZF#$#ENSP00000476637#ENSG00000141258#ENST00000574650#BED ZF#RUN FALSE 39 ENSG00000214717 ZBED1 BED ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR003656;IPR008906;IPR012337; 9189 zinc finger BED-type containing 1 [Source:HGNC Symbol;Acc:HGNC:447] None DBD not tested None None a Yes No Yes 1a1, Direct HQ evidence Yimeng Yin Pratyush Das Yes $#ENSG00000214717#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000370616#ENSG00000214717#ENST00000381218#BED ZF#DUF4413, Dimer_Tnp_hAT$#ENSP00000370620#ENSG00000214717#ENST00000381222#BED ZF#DUF4413, Dimer_Tnp_hAT$#ENSP00000370621#ENSG00000214717#ENST00000381223#BED ZF#DUF4413, Dimer_Tnp_hAT$#ENSP00000419148#ENSG00000214717#ENST00000461691#BED ZF# FALSE 40 ENSG00000177494 ZBED2 BED ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Has a BED domain that should bind DNA, but lacks the dimerization domain (PMID: 20016685). IPR003656; 79413 zinc finger BED-type containing 2 [Source:HGNC Symbol;Acc:HGNC:20710] None not tested not tested None None c Yes No No 4a, two or more datasets predict it as a TF Pratyush Das Jussi Taipale Yes None $#ENSP00000321370#ENSG00000177494#ENST00000317012#BED ZF# FALSE 41 ENSG00000132846 ZBED3 BED ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR003656; 84327 zinc finger BED-type containing 3 [Source:HGNC Symbol;Acc:HGNC:20711] None Full not tested None None c Yes No No 4a, two or more datasets predict it as a TF Yimeng Yin Jussi Taipale Yes None $#ENSP00000255198#ENSG00000132846#ENST00000255198#BED ZF#$#ENSP00000427487#ENSG00000132846#ENST00000511587#BED ZF# FALSE 42 ENSG00000100426 ZBED4 BED ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR003656;IPR008906;IPR012337; 9889 zinc finger BED-type containing 4 [Source:HGNC Symbol;Acc:HGNC:20721] None Full Yes None None b Yes No Yes 4a, two or more datasets predict it as a TF Jussi Taipale Laura Campitelli Yes $#ENSG00000100426#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000216268#ENSG00000100426#ENST00000216268#BED ZF#Dimer_Tnp_hAT FALSE 43 ENSG00000236287 ZBED5 BED ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR003656;IPR012337 58486 zinc finger BED-type containing 5 [Source:HGNC Symbol;Acc:HGNC:30803] None not tested not tested None None No Yes No Yes 3a, decent circumstantial evidence for its role as Laura Campitelli Pratyush Das Yes $#ENSG00000236287#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000415939#ENSG00000236287#ENST00000413761#BED ZF#DUF3887$#ENSP00000398106#ENSG00000236287#ENST00000432999#BED ZF#DUF3887$#ENSP00000433093#ENSG00000236287#ENST00000526020#BED ZF# FALSE 44 ENSG00000257315 ZBED6 BED ZF Yes Inferred motif Monomer or homomultimer In vivo/Misc source None None IPR003656;IPR008906;IPR012337 100381270 zinc finger BED-type containing 6 [Source:HGNC Symbol;Acc:HGNC:33273] None not tested not tested None None No Yes No Yes 2a1, Lower confidence direct evidence Laura Campitelli Arttu Jolma Yes $#ENSG00000257315#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000447879#ENSG00000257315#ENST00000550078#BED ZF#Dimer_Tnp_hAT FALSE 45 ENSG00000221886 ZBED8 BED ZF No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Despite its name, does not have a detectable BED ZF domain. IPR012337 63920 zinc finger BED-type containing 8 [Source:HGNC Symbol;Acc:HGNC:30804] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Jussi Taipale Pratyush Das No $#ENSG00000221886#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000428831#ENSG00000221886#ENST00000523213#Other#Dimer_Tnp_hAT$#ENSP00000386184#ENSG00000221886#ENST00000408953#Other#Dimer_Tnp_hAT FALSE 46 ENSG00000232040 ZBED9 BED ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR001584;IPR003309;IPR008916;IPR012337 None zinc finger BED-type containing 9 [Source:HGNC Symbol;Acc:HGNC:13851] None not tested not tested None None No Yes No Yes 4a, two or more datasets predict it as a TF Yimeng Yin Pratyush Das No None None FALSE 47 ENSG00000106546 AHR bHLH Yes Known motif Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain None IPR000014;IPR001610;IPR011598;IPR013655;IPR013767; 196 aryl hydrocarbon receptor [Source:HGNC Symbol;Acc:HGNC:348] None DBD and Full Yes Obligate_Multimer, 4ZPR is structure of heterodime PMID:12213385, forms heterodimers with ARNT other Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:7592839 Yes 1a1, Direct HQ evidence Tim Hughes Laura Campitelli Yes $#ENSG00000106546#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:11782478$#ENSG00000106546#GO:0004879#ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity#IDA - PMID:10395741 $#ENSP00000242057#ENSG00000106546#ENST00000242057#bHLH#PAS, PAS_11, PAS_3, PAS_4, PAS_9 FALSE 48 ENSG00000063438 AHRR bHLH Yes Inferred motif Monomer or homomultimer In vivo/Misc source None None IPR000014;IPR011598;IPR013767; 57491 aryl-hydrocarbon receptor repressor [Source:HGNC Symbol;Acc:HGNC:346] None DBD and Full not tested None None b Yes No No 4a, two or more datasets predict it as a TF Arttu Jolma Tim Hughes Yes None $#ENSP00000323816#ENSG00000063438#ENST00000316418#bHLH#PAS, PAS_4$#ENSP00000424601#ENSG00000063438#ENST00000505113#bHLH#PAS, PAS_4$#ENSP00000426932#ENSG00000063438#ENST00000506456#bHLH#$#ENSP00000429944#ENSG00000063438#ENST00000504625#bHLH#$#ENSP00000426076#ENSG00000063438#ENST00000511487#bHLH# FALSE 49 ENSG00000143437 ARNT bHLH Yes Known motif Monomer or homomultimer 100 perc ID - in vitro None None IPR000014;IPR001067;IPR001610;IPR011598;IPR013767; 405 aryl hydrocarbon receptor nuclear translocator [Source:HGNC Symbol;Acc:HGNC:700] 4ZPR DBD and Full Yes Obligate_Multimer, the structure4ZPR is a HIF1A-AR Structure has HIF1A - ARNT heterodimer; Heterodimerizes with ARNT, PMID:7539918, PubMed: 26245371 for the crystal structure a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:7592839 Yes 1a1, Direct HQ evidence Yimeng Yin Jussi Taipale Yes $#ENSG00000143437#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:10777486, PMID:1317062$#ENSG00000143437#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#IDA - PMID:7539918, PMID:8756616 $#ENSP00000346372#ENSG00000143437#ENST00000354396#bHLH#PAS, PAS_11, PAS_3, PAS_4, PAS_9$#ENSP00000351407#ENSG00000143437#ENST00000358595#bHLH#PAS, PAS_11, PAS_3, PAS_4, PAS_9$#ENSP00000423851#ENSG00000143437#ENST00000515192#bHLH#PAS, PAS_11, PAS_3, PAS_4, PAS_9$#ENSP00000427571#ENSG00000143437#ENST00000505755#bHLH#PAS, PAS_11, PAS_3, PAS_4, PAS_9 FALSE 50 ENSG00000172379 ARNT2 bHLH Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000014;IPR001067;IPR001610;IPR011598;IPR013767; 100847042 aryl hydrocarbon receptor nuclear translocator 2 [Source:HGNC Symbol;Acc:HGNC:16876] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:8657146 Yes 1a1, Direct HQ evidence Sam Lambert Matt Weirauch Yes $#ENSG00000172379#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IDA - PMID:24465693$#ENSG00000172379#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000172379#GO:0003700#sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024 $#ENSP00000307479#ENSG00000172379#ENST00000303329#bHLH#PAS, PAS_11, PAS_3, PAS_4, PAS_9$#ENSP00000453792#ENSG00000172379#ENST00000527771#bHLH#PAS, PAS_11, PAS_3, PAS_4, PAS_9$#ENSP00000479393#ENSG00000172379#ENST00000622346#bHLH#PAS, PAS_11, PAS_3, PAS_4, PAS_9$#ENSP00000452961#ENSG00000172379#ENST00000525103#bHLH# FALSE 51 ENSG00000133794 ARNTL bHLH Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000014;IPR001067;IPR001610;IPR011598;IPR013767; 406 aryl hydrocarbon receptor nuclear translocator like [Source:HGNC Symbol;Acc:HGNC:701] 4H10 DBD and Full Yes None Structure is ARNTL-CLOCK heterodimer a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; TF PPI_PMIDS:9576906;9616112 Yes 1a1, Direct HQ evidence Yimeng Yin Arttu Jolma Yes $#ENSG00000133794#GO:0000982#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#ISS - GO_REF:0000024 $#ENSP00000374357#ENSG00000133794#ENST00000389707#bHLH#PAS, PAS_11, PAS_3, PAS_4, PAS_9$#ENSP00000385915#ENSG00000133794#ENST00000401424#bHLH#PAS, PAS_11, PAS_3, PAS_4, PAS_9$#ENSP00000384517#ENSG00000133794#ENST00000403290#bHLH#PAS, PAS_11, PAS_3, PAS_4, PAS_9$#ENSP00000385897#ENSG00000133794#ENST00000403482#bHLH#PAS, PAS_11, PAS_3, PAS_4, PAS_9$#ENSP00000385581#ENSG00000133794#ENST00000403510#bHLH#PAS, PAS_11, PAS_3, PAS_4, PAS_9$#ENSP00000436721#ENSG00000133794#ENST00000482049#bHLH# FALSE 52 ENSG00000029153 ARNTL2 bHLH Yes Inferred motif Obligate heteromer High-throughput in vitro None ARNTL2 Forms heterodimers with CLOCK and NPAS2 (PMID:10864977 ). IPR000014;IPR001067;IPR011598;IPR013767 56938 aryl hydrocarbon receptor nuclear translocator like 2 [Source:HGNC Symbol;Acc:HGNC:18984] None DBD and Full Yes None PMID:10864977 ARNTL2 Forms heterodimers with CLOCK and NPAS2 a Yes No Yes 1a2, Orthologous HQ evidence Arttu Jolma Jussi Taipale Yes $#ENSG00000029153#GO:0000982#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:15147242$#ENSG00000029153#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:12055078 | NAS - PMID:11018023 $#ENSP00000261178#ENSG00000029153#ENST00000261178#bHLH#PAS, PAS_11, PAS_3, PAS_4, PAS_9$#ENSP00000266503#ENSG00000029153#ENST00000266503#bHLH#PAS, PAS_11, PAS_3, PAS_4, PAS_9$#ENSP00000312247#ENSG00000029153#ENST00000311001#bHLH#PAS, PAS_11, PAS_3, PAS_4, PAS_9$#ENSP00000379238#ENSG00000029153#ENST00000395901#bHLH#PAS, PAS_11, PAS_3, PAS_4, PAS_9$#ENSP00000400185#ENSG00000029153#ENST00000457040#bHLH#PAS, PAS_11, PAS_3, PAS_4, PAS_9$#ENSP00000445836#ENSG00000029153#ENST00000542388#bHLH#PAS, PAS_11, PAS_2, PAS_3, PAS_4, PAS_9$#ENSP00000438545#ENSG00000029153#ENST00000546179#bHLH#PAS, PAS_11, PAS_2, PAS_3, PAS_4, PAS_9 FALSE 53 ENSG00000139352 ASCL1 bHLH Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR011598; 429 achaete-scute family bHLH transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:738] None DBD Yes None pmid:10903890, prefers heterodimerization with TCF3 a Yes TF Gene_Transcription Factor Binding: tf co-factor binding; DNA-Binding: sequence-specific_DNA Binding; TF PPI; Transactivation_PMIDS:8662987;8900141 Yes 1a1, Direct HQ evidence Pratyush Das Sam Lambert Yes $#ENSG00000139352#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:11736660$#ENSG00000139352#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:10903890 $#ENSP00000266744#ENSG00000139352#ENST00000266744#bHLH# FALSE 54 ENSG00000183734 ASCL2 bHLH Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR011598; 430 achaete-scute family bHLH transcription factor 2 [Source:HGNC Symbol;Acc:HGNC:739] None DBD and Full Yes None None a Yes No Yes 1a1, Direct HQ evidence Yimeng Yin Sam Lambert Yes $#ENSG00000183734#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:14561729$#ENSG00000183734#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:8751384 $#ENSP00000332293#ENSG00000183734#ENST00000331289#bHLH# FALSE 55 ENSG00000176009 ASCL3 bHLH Yes Inferred motif Obligate heteromer High-throughput in vitro None ASCL1 heterodimerizes with TCF3; TCF4 and TCF12 (PMID: 24835951). IPR011598; 56676 Achaete-scute family bHLH transcription factor 3 [Source:HGNC Symbol;Acc:HGNC:740] None DBD Yes None ASCL1 heterodimerizes with TCF3 a Yes No No 3a, decent circumstantial evidence for its role as Arttu Jolma Pratyush Das Yes $#ENSG00000176009#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IEA - GO_REF:0000019$#ENSG00000176009#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000435770#ENSG00000176009#ENST00000531618#bHLH# FALSE 56 ENSG00000187855 ASCL4 bHLH Yes Inferred motif Monomer or homomultimer High-throughput in vitro None Probably heterodimerizes with TCF3; TCF4 or TCF12 like the other ASCL TFs IPR011598; 121549 Achaete-scute family bHLH transcription factor 4 [Source:HGNC Symbol;Acc:HGNC:24311] None DBD and Full not tested None ASCL1 heterodimerizes with TCF3 a Yes No No 3a, decent circumstantial evidence for its role as Arttu Jolma Sam Lambert Yes $#ENSG00000187855#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000345420#ENSG00000187855#ENST00000342331#bHLH# FALSE 57 ENSG00000232237 ASCL5 bHLH Yes Inferred motif Monomer or homomultimer High-throughput in vitro None Probably heterodimerizes with TCF3; TCF4 or TCF12 like the other ASCL TFs IPR011598 647219 Achaete-scute family bHLH transcription factor 5 [Source:HGNC Symbol;Acc:HGNC:33169] None not tested not tested None ASCL1 heterodimerizes with TCF3 No Yes No Yes 3a, decent circumstantial evidence for its role as Jussi Taipale Yimeng Yin Yes $#ENSG00000232237#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000472681#ENSG00000232237#ENST00000449188#bHLH#$#ENSP00000469019#ENSG00000232237#ENST00000458416#bHLH# FALSE 58 ENSG00000172238 ATOH1 bHLH Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR011598; 474 atonal bHLH transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:797] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_Co-activation_PMIDS:14757642 Yes 1a1, Direct HQ evidence Matt Weirauch Jussi Taipale Yes $#ENSG00000172238#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000172238#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:8872459 $#ENSP00000302216#ENSG00000172238#ENST00000306011#bHLH# FALSE 59 ENSG00000179774 ATOH7 bHLH Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR011598; 220202 atonal bHLH transcription factor 7 [Source:HGNC Symbol;Acc:HGNC:13907] None DBD and Full Yes None None a Yes TF Gene Candidate__Transactivation_PMIDS:7721778;15882586;17653051 No 1a1, Direct HQ evidence Laura Campitelli Yimeng Yin Yes None $#ENSP00000362777#ENSG00000179774#ENST00000373673#bHLH# FALSE 60 ENSG00000168874 ATOH8 bHLH Yes Inferred motif Monomer or homomultimer High-throughput in vitro None None IPR011598; 84913 atonal bHLH transcription factor 8 [Source:HGNC Symbol;Acc:HGNC:24126] None DBD Yes None ATOH8 Is thought to make a heterodimer with TCF3 c Yes TF Gene Candidate_DNA-Binding: sequence-specific_Other_PMIDS:11733035;12419857 Yes 1a2, Orthologous HQ evidence Laura Campitelli Jussi Taipale Yes $#ENSG00000168874#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:24236640 $#ENSP00000304676#ENSG00000168874#ENST00000306279#bHLH# FALSE 61 ENSG00000180535 BHLHA15 bHLH Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR011598; 168620 basic helix-loop-helix family member a15 [Source:HGNC Symbol;Acc:HGNC:22265] None DBD and Full Yes None None a Yes No No 1a1, Direct HQ evidence Arttu Jolma Jussi Taipale Yes $#ENSG00000180535#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IEA - GO_REF:0000019 $#ENSP00000476312#ENSG00000180535#ENST00000609256#bHLH#$#ENSP00000326391#ENSG00000180535#ENST00000314018#bHLH# FALSE 62 ENSG00000205899 BHLHA9 bHLH Yes Likely to be sequence specific TF Obligate heteromer No motif None Protein heterodimerizes with TCF3; TCF4 and TCF12 (PMID: 25466284). IPR011598; 727857 basic helix-loop-helix family member a9 [Source:HGNC Symbol;Acc:HGNC:35126] None DBD not tested None None c Yes No No 4a, two or more datasets predict it as a TF Pratyush Das Arttu Jolma Yes None $#ENSP00000375248#ENSG00000205899#ENST00000391429#bHLH# FALSE 63 ENSG00000180828 BHLHE22 bHLH Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR011598; 27319 basic helix-loop-helix family member e22 [Source:HGNC Symbol;Acc:HGNC:11963] None DBD Yes None Vaquerizas dataset used old symbol BHLHB5 a Yes No Yes 1a1, Direct HQ evidence Yimeng Yin Arttu Jolma Yes $#ENSG00000180828#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IEA - GO_REF:0000002 $#ENSP00000318799#ENSG00000180828#ENST00000321870#bHLH# FALSE 64 ENSG00000125533 BHLHE23 bHLH Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR011598; 128408 basic helix-loop-helix family member e23 [Source:HGNC Symbol;Acc:HGNC:16093] None DBD and Full Yes None Vaquerizas dataset used old symbol BHLHB4; pmid:15363390, protein is required for rod cell maturation a Yes No No 1a1, Direct HQ evidence Sam Lambert Pratyush Das Yes None $#ENSP00000359371#ENSG00000125533#ENST00000370346#bHLH#$#ENSP00000480998#ENSG00000125533#ENST00000612929#bHLH# FALSE 65 ENSG00000134107 BHLHE40 bHLH Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR003650;IPR011598 8553 basic helix-loop-helix family member e40 [Source:HGNC Symbol;Acc:HGNC:1046] None DBD and Full Yes None Cell2013 has old symbol BHLHB2 a Yes TF Gene_Transcription Factor Binding: tf co-factor binding; DNA-Binding: sequence-specific_DNA Binding_PMIDS:12297495;12397359 Yes 1a1, Direct HQ evidence Jussi Taipale Sam Lambert Yes $#ENSG00000134107#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IDA - PMID:12397359$#ENSG00000134107#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:12624110, PMID:15193144, PMID:18411297$#ENSG00000134107#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:9240428$#ENSG00000134107#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024$#ENSG00000134107#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:18411297 $#ENSP00000256495#ENSG00000134107#ENST00000256495#bHLH#Hairy_orange FALSE 66 ENSG00000123095 BHLHE41 bHLH Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR003650;IPR011598 79365 basic helix-loop-helix family member e41 [Source:HGNC Symbol;Acc:HGNC:16617] None DBD and Full Yes None Cell2013 has old symbol BHLHB3 b Yes TF Gene_DNA-Binding: sequence-specific; Transcription Factor Binding: tf co-factor binding_DNA Binding; Other_PMIDS:12657651;15448136 Yes 1a1, Direct HQ evidence Tim Hughes Yimeng Yin Yes $#ENSG00000123095#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#ISS - GO_REF:0000024$#ENSG00000123095#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024 $#ENSP00000242728#ENSG00000123095#ENST00000242728#bHLH#Hairy_orange FALSE 67 ENSG00000250709 CCDC169-SOHLH2 bHLH Yes Known motif Monomer or homomultimer 100 perc ID - in vitro None None IPR011598;IPR028022 100526761 CCDC169-SOHLH2 readthrough [Source:HGNC Symbol;Acc:HGNC:38866] None not tested not tested None None No Yes No No 1a2, Orthologous HQ evidence Arttu Jolma Pratyush Das No None $#ENSP00000421868#ENSG00000250709#ENST00000511166#bHLH#DUF4600 FALSE 68 ENSG00000134852 CLOCK bHLH Yes Known motif Monomer or homomultimer High-throughput in vitro None Can also bind as heterodimer with ARNTL. IPR000014;IPR001067;IPR001610;IPR011598;IPR013767; 9575 clock circadian regulator [Source:HGNC Symbol;Acc:HGNC:2082] 4H10 DBD and Full Yes None Structure is ARNTL-CLOCK heterodimer a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:9616112;15147242;15500444 Yes 1a1, Direct HQ evidence Arttu Jolma Laura Campitelli Yes $#ENSG00000134852#GO:0000982#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#ISS - GO_REF:0000024$#ENSG00000134852#GO:0003700#sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024$#ENSG00000134852#GO:0051092#positive regulation of NF-kappaB transcription factor activity#ISS - GO_REF:0000024 $#ENSP00000308741#ENSG00000134852#ENST00000309964#bHLH#PAS, PAS_11, PAS_3, PAS_9$#ENSP00000370723#ENSG00000134852#ENST00000381322#bHLH#PAS, PAS_11, PAS_3, PAS_9$#ENSP00000426983#ENSG00000134852#ENST00000513440#bHLH#PAS, PAS_11, PAS_3, PAS_9$#ENSP00000396649#ENSG00000134852#ENST00000435527#bHLH#PAS, PAS_9 FALSE 69 ENSG00000116016 EPAS1 bHLH Yes Known motif Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain None IPR000014;IPR001067;IPR001610;IPR011598;IPR013767;IPR014887;IPR021537; 2034 endothelial PAS domain protein 1 [Source:HGNC Symbol;Acc:HGNC:3374] 4ZPK DBD and Full Yes Obligate_Multimer 4ZPK is EPAS1 - ARNT heterodimer; Heterodimerizes with ARNT, PMID: 26245371 for the crystal structure; a Yes TF Gene_Transcription Factor Binding: tf co-factor binding; DNA-Binding: sequence-specific_Co-activation; DNA Binding_PMIDS:15190133 Yes 1a1, Direct HQ evidence Tim Hughes Sam Lambert Yes $#ENSG00000116016#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000116016#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019 $#ENSP00000263734#ENSG00000116016#ENST00000263734#bHLH#HIF-1, HIF-1a_CTAD, PAS, PAS_11, PAS_3, PAS_4, PAS$#ENSP00000406137#ENSG00000116016#ENST00000449347#bHLH#PAS, PAS_11, PAS_3, PAS_4, PAS_9 FALSE 70 ENSG00000146618 FERD3L bHLH Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR011598; 222894 Fer3-like bHLH transcription factor [Source:HGNC Symbol;Acc:HGNC:16660] None DBD and Full Yes None None c Yes No No 1a1, Direct HQ evidence Laura Campitelli Arttu Jolma Yes $#ENSG00000146618#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IEA - GO_REF:0000019 $#ENSP00000275461#ENSG00000146618#ENST00000275461#bHLH# FALSE 71 ENSG00000183733 FIGLA bHLH Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR011598; 344018 folliculogenesis specific bHLH transcription factor [Source:HGNC Symbol;Acc:HGNC:24669] None DBD Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:9362457;15044608 No 1a1, Direct HQ evidence Arttu Jolma Pratyush Das Yes $#ENSG00000183733#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019 $#ENSP00000333097#ENSG00000183733#ENST00000332372#bHLH# FALSE 72 ENSG00000113196 HAND1 bHLH Yes Known motif Obligate heteromer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain Obligate heteromer (PMID: 10611232). IPR011598; 9421 heart and neural crest derivatives expressed 1 [Source:HGNC Symbol;Acc:HGNC:4807] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:7791788;11802795;16043483;7671815;15509787;16043483;10611232;16043483 Yes 2a1, Lower confidence direct evidence Jussi Taipale Pratyush Das Yes $#ENSG00000113196#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:11802795$#ENSG00000113196#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:11802795 $#ENSP00000231121#ENSG00000113196#ENST00000231121#bHLH# FALSE 73 ENSG00000164107 HAND2 bHLH Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR011598; 9464 heart and neural crest derivatives expressed 2 [Source:HGNC Symbol;Acc:HGNC:4808] None DBD and Full Yes None None a Yes TF Gene_Transcription Factor Binding: tf co-factor binding; DNA-Binding: sequence-specific_TF PPI; Transactivation_PMIDS:11812799;12392994 Yes 1a1, Direct HQ evidence Sam Lambert Pratyush Das Yes $#ENSG00000164107#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:15486975$#ENSG00000164107#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019 $#ENSP00000352565#ENSG00000164107#ENST00000359562#bHLH#$#ENSP00000477638#ENSG00000164107#ENST00000621866#bHLH# FALSE 74 ENSG00000187821 HELT bHLH Yes Inferred motif Monomer or homomultimer High-throughput in vitro None Can form homodimers or heterodimers with HEY2 and HES5, suggesting also that the HELT homodimer is dependent of a additional Orange domain while the HEY2 heterodimer requires just the DBD (PMID: 14764602). IPR003650;IPR011598 391723 helt bHLH transcription factor [Source:HGNC Symbol;Acc:HGNC:33783] None DBD Yes None PMID: 14764602 shows that it can form homodimers or heterodimers with HEY2 and HES5, suggesting also that the homodimer or heterodimer is dependent of a additional Orange domain while the HEY2 heterodimer requires just the DBD c Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:14764602;15071116 Yes 3a, decent circumstantial evidence for its role as Arttu Jolma Pratyush Das Yes $#ENSG00000187821#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019 $#ENSP00000422140#ENSG00000187821#ENST00000505610#bHLH#Hairy_orange$#ENSP00000426033#ENSG00000187821#ENST00000515777#bHLH#Hairy_orange$#ENSP00000343464#ENSG00000187821#ENST00000338875#bHLH#Hairy_orange FALSE 75 ENSG00000114315 HES1 bHLH Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR003650;IPR011598 3280 hes family bHLH transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:5192] None DBD Yes None None a Yes No Yes 1a1, Direct HQ evidence Matt Weirauch Pratyush Das Yes $#ENSG00000114315#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#ISS - GO_REF:0000024$#ENSG00000114315#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:17681138 $#ENSP00000232424#ENSG00000114315#ENST00000232424#bHLH#Hairy_orange FALSE 76 ENSG00000069812 HES2 bHLH Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR003650;IPR011598 54626 hes family bHLH transcription factor 2 [Source:HGNC Symbol;Acc:HGNC:16005] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:8354270 No 1a1, Direct HQ evidence Sam Lambert Pratyush Das Yes None $#ENSP00000367065#ENSG00000069812#ENST00000377834#bHLH#Hairy_orange$#ENSP00000367068#ENSG00000069812#ENST00000377837#bHLH#$#ENSP00000367067#ENSG00000069812#ENST00000377836#bHLH#$#ENSP00000465270#ENSG00000069812#ENST00000489730#bHLH#$#ENSP00000465248#ENSG00000069812#ENST00000487437#bHLH# FALSE 77 ENSG00000173673 HES3 bHLH Yes Inferred motif Monomer or homomultimer High-throughput in vitro None None IPR011598; 390992 hes family bHLH transcription factor 3 [Source:HGNC Symbol;Acc:HGNC:26226] None DBD Yes None None c Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:10858455 No 4a, two or more datasets predict it as a TF Sam Lambert Laura Campitelli Yes None $#ENSP00000367130#ENSG00000173673#ENST00000377898#bHLH# FALSE 78 ENSG00000188290 HES4 bHLH Yes Inferred motif Monomer or homomultimer High-throughput in vitro None None IPR003650;IPR011598 57801 hes family bHLH transcription factor 4 [Source:HGNC Symbol;Acc:HGNC:24149] None DBD not tested None None b Yes No No 1a2, Orthologous HQ evidence Sam Lambert Pratyush Das Yes None $#ENSP00000304595#ENSG00000188290#ENST00000304952#bHLH#Hairy_orange$#ENSP00000393198#ENSG00000188290#ENST00000428771#bHLH#Hairy_orange$#ENSP00000425085#ENSG00000188290#ENST00000484667#bHLH#Hairy_orange FALSE 79 ENSG00000197921 HES5 bHLH Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR003650;IPR011598 388585 hes family bHLH transcription factor 5 [Source:HGNC Symbol;Acc:HGNC:19764] None DBD and Full Yes None None b Yes TF Gene_DNA-Binding: sequence-specific_TF PPI_PMIDS:15156153 Yes 1a1, Direct HQ evidence Yimeng Yin Arttu Jolma Yes $#ENSG00000197921#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#ISS - GO_REF:0000024 $#ENSP00000367714#ENSG00000197921#ENST00000378453#bHLH#Hairy_orange FALSE 80 ENSG00000144485 HES6 bHLH Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR003650;IPR011598 55502 hes family bHLH transcription factor 6 [Source:HGNC Symbol;Acc:HGNC:18254] None DBD and Full Yes None None x Yes TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:10851137;10976052 Yes 1a1, Direct HQ evidence Arttu Jolma Pratyush Das Yes $#ENSG00000144485#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IEA - GO_REF:0000019$#ENSG00000144485#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:10851137 $#ENSP00000272937#ENSG00000144485#ENST00000272937#bHLH#Hairy_orange$#ENSP00000387155#ENSG00000144485#ENST00000409002#bHLH#Hairy_orange$#ENSP00000387215#ENSG00000144485#ENST00000409160#bHLH#$#ENSP00000387343#ENSG00000144485#ENST00000409182#bHLH#Hairy_orange$#ENSP00000387107#ENSG00000144485#ENST00000409356#bHLH#$#ENSP00000387008#ENSG00000144485#ENST00000409574#bHLH#$#ENSP00000401797#ENSG00000144485#ENST00000417803#bHLH#$#ENSP00000392596#ENSG00000144485#ENST00000436051#bHLH#$#ENSP00000390870#ENSG00000144485#ENST00000450098#bHLH# FALSE 81 ENSG00000179111 HES7 bHLH Yes Known motif Monomer or homomultimer High-throughput in vitro None Also forms heterodimers. IPR003650;IPR011598 84667 hes family bHLH transcription factor 7 [Source:HGNC Symbol;Acc:HGNC:15977] None DBD Yes None None a Yes TF Gene Candidate__Other_PMIDS:11260262;12783854 No 1a1, Direct HQ evidence Yimeng Yin Pratyush Das Yes None $#ENSP00000314774#ENSG00000179111#ENST00000317814#bHLH#$#ENSP00000446205#ENSG00000179111#ENST00000541682#bHLH#$#ENSP00000462491#ENSG00000179111#ENST00000577735#bHLH# FALSE 82 ENSG00000164683 HEY1 bHLH Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR003650;IPR011598 23462 hes related family bHLH transcription factor with YRPW motif 1 [Source:HGNC Symbol;Acc:HGNC:4880] None DBD and Full Yes None None a Yes TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_Transactivation_PMIDS:16199874 Yes 1a1, Direct HQ evidence Laura Campitelli Pratyush Das Yes $#ENSG00000164683#GO:0000983#RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024$#ENSG00000164683#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:15485867 $#ENSP00000338272#ENSG00000164683#ENST00000337919#bHLH#Hairy_orange$#ENSP00000346761#ENSG00000164683#ENST00000354724#bHLH#Hairy_orange$#ENSP00000429792#ENSG00000164683#ENST00000523976#bHLH#Hairy_orange$#ENSP00000429705#ENSG00000164683#ENST00000518733#bHLH#Hairy_orange FALSE 83 ENSG00000135547 HEY2 bHLH Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR003650;IPR011598 23493 hes related family bHLH transcription factor with YRPW motif 2 [Source:HGNC Symbol;Acc:HGNC:4881] None DBD and Full Yes None Can also form heterodimer with HELT a Yes No Yes 1a1, Direct HQ evidence Tim Hughes Yimeng Yin Yes $#ENSG00000135547#GO:0000983#RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024$#ENSG00000135547#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:15485867 $#ENSP00000357348#ENSG00000135547#ENST00000368364#bHLH#Hairy_orange$#ENSP00000357349#ENSG00000135547#ENST00000368365#bHLH#Hairy_orange FALSE 84 ENSG00000163909 HEYL bHLH Yes Inferred motif Monomer or homomultimer High-throughput in vitro None None IPR003650;IPR011598 26508 hes related family bHLH transcription factor with YRPW motif-like [Source:HGNC Symbol;Acc:HGNC:4882] None DBD and Full not tested None None a Yes No Yes 1a2, Orthologous HQ evidence Jussi Taipale Yimeng Yin Yes $#ENSG00000163909#GO:0000983#RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024$#ENSG00000163909#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000163909#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:15485867$#ENSG00000163909#GO:2000824#negative regulation of androgen receptor activity#IDA - PMID:21454491 $#ENSP00000361943#ENSG00000163909#ENST00000372852#bHLH#Hairy_orange FALSE 85 ENSG00000100644 HIF1A bHLH Yes Known motif Obligate heteromer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain Binds as obligate heteromer with ARNT (PMID: 9027737). IPR000014;IPR001321;IPR001610;IPR011598;IPR013767;IPR014887;IPR021537; 3091 hypoxia inducible factor 1 alpha subunit [Source:HGNC Symbol;Acc:HGNC:4910] 4ZPR DBD and Full Yes Obligate_Multimer 4ZPR is structure of HIF1A - ARNT heterodimer;Heterodimerizes with ARNT, PMID:7539918, PubMed: 26245371 for the crystal structure a Yes TF Gene_DNA-Binding: sequence-specific_Transactivation_PMIDS:12133832;15111179;15906272 Yes 1a1, Direct HQ evidence Yimeng Yin Matt Weirauch Yes $#ENSG00000100644#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000100644#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IMP - PMID:24983504$#ENSG00000100644#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:11782478, PMID:18658046 | TAS - PMID:15$#ENSG00000100644#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#IDA - PMID:7539918, PMID:8387214, PMID:8756616, PM $#ENSP00000323326#ENSG00000100644#ENST00000323441#bHLH#HIF-1, PAS, PAS_11, PAS_3, PAS_4, PAS_9$#ENSP00000338018#ENSG00000100644#ENST00000337138#bHLH#HIF-1, HIF-1a_CTAD, PAS, PAS_11, PAS_3, PAS_4, PAS$#ENSP00000378446#ENSG00000100644#ENST00000394997#bHLH#HIF-1, HIF-1a_CTAD, PAS, PAS_11, PAS_3, PAS_4, PAS$#ENSP00000437955#ENSG00000100644#ENST00000539097#bHLH#HIF-1, HIF-1a_CTAD, PAS, PAS_11, PAS_3, PAS_4, PAS$#ENSP00000451696#ENSG00000100644#ENST00000557538#bHLH#HIF-1, HIF-1a_CTAD, PAS, PAS_11, PAS_3, PAS_4, PAS FALSE 86 ENSG00000124440 HIF3A bHLH Yes Inferred motif Obligate heteromer In vivo/Misc source None Binds DNA as a heterodimer with ARNT and ARNT2; reviewed in (PMID: 24099156). IPR000014;IPR001610;IPR011598;IPR013767;IPR021537; 64344 hypoxia inducible factor 3 alpha subunit [Source:HGNC Symbol;Acc:HGNC:15825] None DBD Yes None None a Yes No Yes 2a1, Lower confidence direct evidence Arttu Jolma Pratyush Das Yes $#ENSG00000124440#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000300862#ENSG00000124440#ENST00000300862#bHLH#HIF-1, PAS, PAS_11, PAS_3, PAS_4, PAS_9$#ENSP00000366898#ENSG00000124440#ENST00000377670#bHLH#HIF-1, PAS, PAS_11, PAS_3, PAS_4, PAS_9$#ENSP00000244303#ENSG00000124440#ENST00000244303#bHLH#HIF-1, PAS, PAS_11, PAS_3, PAS_4, PAS_9$#ENSP00000434653#ENSG00000124440#ENST00000472815#bHLH#PAS, PAS_11, PAS_3, PAS_4, PAS_9$#ENSP00000471560#ENSG00000124440#ENST00000600383#bHLH#HIF-1, PAS, PAS_11, PAS_3, PAS_4, PAS_9 FALSE 87 ENSG00000125968 ID1 bHLH No Unlikely to be sequence specific TF Not a DNA binding protein No motif None ID bHLH proteins lack the basic region and should not be able to bind DNA. The HT-SELEX motif for ID4 is likely by a co-precipitated protein or it is a contamination IPR011598; 3397 inhibitor of DNA binding 1, HLH protein [Source:HGNC Symbol;Acc:HGNC:5360] None DBD and Full Yes None ID-proteins seems to lack the ability to bind DNA and presumably works as an inhibitor that sequesters TCF3 and other bHLH factors a Yes TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_Other_PMIDS:2156629;11234019 Yes 1a2, Orthologous HQ evidence Yimeng Yin Laura Campitelli Yes $#ENSG00000125968#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019$#ENSG00000125968#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:15138269 $#ENSP00000365280#ENSG00000125968#ENST00000376112#bHLH#$#ENSP00000365273#ENSG00000125968#ENST00000376105#bHLH# FALSE 88 ENSG00000115738 ID2 bHLH No Unlikely to be sequence specific TF Not a DNA binding protein No motif None ID bHLH proteins lack the basic region and should not be able to bind DNA. The HT-SELEX motif for ID4 is likely by a co-precipitated protein or it is a contamination IPR011598; 3398 inhibitor of DNA binding 2, HLH protein [Source:HGNC Symbol;Acc:HGNC:5361] None DBD and Full Yes None None a Yes TF Gene Candidate__DNA Binding_PMIDS:1922066;7565756 Yes 1a1, Direct HQ evidence Yimeng Yin Sam Lambert Yes $#ENSG00000115738#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:14627819 $#ENSP00000385465#ENSG00000115738#ENST00000331129#bHLH#$#ENSP00000379585#ENSG00000115738#ENST00000396290#bHLH#$#ENSP00000234091#ENSG00000115738#ENST00000234091#bHLH# FALSE 89 ENSG00000117318 ID3 bHLH No Unlikely to be sequence specific TF Not a DNA binding protein No motif None ID bHLH proteins lack the basic region and should not be able to bind DNA. The HT-SELEX motif for ID4 is likely by a co-precipitated protein or it is a contamination IPR011598; 3399 inhibitor of DNA binding 3, HLH protein [Source:HGNC Symbol;Acc:HGNC:5362] None DBD and Full Yes None ID-proteins seems to lack the ability to bind DNA and presumably works as an inhibitor that sequesters TCF3 and other bHLH factors a Yes TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_Other_PMIDS:15016815 Yes 1a2, Orthologous HQ evidence Arttu Jolma Pratyush Das Yes $#ENSG00000117318#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019$#ENSG00000117318#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:14627819 $#ENSP00000363689#ENSG00000117318#ENST00000374561#bHLH# FALSE 90 ENSG00000172201 ID4 bHLH No Unlikely to be sequence specific TF Not a DNA binding protein No motif None ID bHLH proteins lack the basic region and should not be able to bind DNA. The HT-SELEX motif for ID4 is likely by a co-precipitated protein or it is a contamination IPR011598; 3400 inhibitor of DNA binding 4, HLH protein [Source:HGNC Symbol;Acc:HGNC:5363] None DBD and Full Yes None Cell paper data is probably contamination, these should be transcriptional inhibitors that sequester bHLH proteins by making heterodimers that wont bind DNA. Possibly a contaminated HT-SELEX-experiment or reflect binding specificity of a binding part c Yes TF Gene Candidate__Transactivation_PMIDS:7665172;8139914 No 3a, decent circumstantial evidence for its role as Sam Lambert Pratyush Das Yes None $#ENSP00000367972#ENSG00000172201#ENST00000378700#bHLH# FALSE 91 ENSG00000104903 LYL1 bHLH Yes Inferred motif Obligate heteromer In vivo/Misc source None TAL1, TAL2 and LYL are very similar and have a basic region with a bulky tryptophan inserting into the cluster of the basic residues. Binds DNA as a heterodimer with TCF3 (PDB:2YPB and PDB:2YPA). IPR011598; 4066 lymphoblastic leukemia associated hematopoiesis regulator 1 [Source:HGNC Symbol;Acc:HGNC:6734] None DBD and Full Yes None PMID:8628307 LYL1 makes heterodimer with TCF3 a Yes No Yes 1a2, Orthologous HQ evidence Matt Weirauch Pratyush Das Yes $#ENSG00000104903#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000264824#ENSG00000104903#ENST00000264824#bHLH#$#ENSP00000468122#ENSG00000104903#ENST00000590974#bHLH# FALSE 92 ENSG00000125952 MAX bHLH Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR011598; 4149 MYC associated factor X [Source:HGNC Symbol;Acc:HGNC:6913] 1AN2 DBD and Full Yes None Structure is a homodimer a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:8265351 Yes 1a1, Direct HQ evidence Pratyush Das Jussi Taipale Yes $#ENSG00000125952#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019 $#ENSP00000246163#ENSG00000125952#ENST00000246163#bHLH#$#ENSP00000284165#ENSG00000125952#ENST00000284165#bHLH#$#ENSP00000351175#ENSG00000125952#ENST00000358402#bHLH#$#ENSP00000351490#ENSG00000125952#ENST00000358664#bHLH#$#ENSP00000452286#ENSG00000125952#ENST00000555667#bHLH#$#ENSP00000480127#ENSG00000125952#ENST00000618858#bHLH#$#ENSP00000342482#ENSG00000125952#ENST00000341653#bHLH#$#ENSP00000450818#ENSG00000125952#ENST00000556443#bHLH#$#ENSP00000452378#ENSG00000125952#ENST00000556979#bHLH#$#ENSP00000450955#ENSG00000125952#ENST00000557277#bHLH# FALSE 93 ENSG00000166823 MESP1 bHLH Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR011598; 55897 mesoderm posterior bHLH transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:29658] None DBD Yes None None c Yes No Yes 1a1, Direct HQ evidence Arttu Jolma Sam Lambert Yes $#ENSG00000166823#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000166823#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:18297060 $#ENSP00000300057#ENSG00000166823#ENST00000300057#bHLH# FALSE 94 ENSG00000188095 MESP2 bHLH Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR011598; 145873 mesoderm posterior bHLH transcription factor 2 [Source:HGNC Symbol;Acc:HGNC:29659] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific; Transcription Factor Binding: tf co-factor binding_Co-activation_PMIDS:16728472 No 1a1, Direct HQ evidence Sam Lambert Arttu Jolma Yes None $#ENSP00000342392#ENSG00000188095#ENST00000341735#bHLH#$#ENSP00000452998#ENSG00000188095#ENST00000560219#bHLH# FALSE 95 ENSG00000187098 MITF bHLH Yes Known motif Monomer or homomultimer 100 perc ID - in vitro None Binds DNA both as homo- and heterodimers (PMID: 23207919). The structure 4ATI is a homodimer with DNA GTTAGCACATGACCCT. IPR011598;IPR021802 4286 melanogenesis associated transcription factor [Source:HGNC Symbol;Acc:HGNC:7105] 4ATI DBD and Full Yes None Based on pmid:23207919, it binds DNA both as homo- and heterodimers, The structure 4ATI is homodimer with DNA GTTAGCACATGACCCT a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:14737107;15716956 Yes 1a1, Direct HQ evidence Pratyush Das Arttu Jolma Yes $#ENSG00000187098#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:14737107, PMID:20530484 | IMP - PMID:14$#ENSG00000187098#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#NAS - PMID:24769727 $#ENSP00000324246#ENSG00000187098#ENST00000314557#bHLH#DUF3371, MITF_TFEB_C_3_N$#ENSP00000295600#ENSG00000187098#ENST00000352241#bHLH#DUF3371, MITF_TFEB_C_3_N$#ENSP00000481286#ENSG00000187098#ENST00000394348#bHLH#MITF_TFEB_C_3_N$#ENSP00000377880#ENSG00000187098#ENST00000394351#bHLH#DUF3371, MITF_TFEB_C_3_N$#ENSP00000391276#ENSG00000187098#ENST00000457080#bHLH#MITF_TFEB_C_3_N$#ENSP00000435909#ENSG00000187098#ENST00000531774#bHLH#DUF3371, MITF_TFEB_C_3_N$#ENSP00000324443#ENSG00000187098#ENST00000314589#bHLH#DUF3371, MITF_TFEB_C_3_N$#ENSP00000418845#ENSG00000187098#ENST00000472437#bHLH#DUF3371, MITF_TFEB_C_3_N$#ENSP00000411389#ENSG00000187098#ENST00000433517#bHLH#MITF_TFEB_C_3_N FALSE 96 ENSG00000108788 MLX bHLH Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR011598; 6945 MLX, MAX dimerization protein [Source:HGNC Symbol;Acc:HGNC:11645] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:10918583;14742444 Yes 1a1, Direct HQ evidence Jussi Taipale Arttu Jolma Yes $#ENSG00000108788#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IDA - PMID:10918583 | IMP - PMID:10918583$#ENSG00000108788#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:10918583 $#ENSP00000246912#ENSG00000108788#ENST00000246912#bHLH#$#ENSP00000320913#ENSG00000108788#ENST00000346833#bHLH#$#ENSP00000416627#ENSG00000108788#ENST00000435881#bHLH#$#ENSP00000464697#ENSG00000108788#ENST00000591024#bHLH# FALSE 97 ENSG00000175727 MLXIP bHLH Yes Inferred motif Obligate heteromer High-throughput in vitro None None IPR011598; 22877 MLX interacting protein [Source:HGNC Symbol;Acc:HGNC:17055] None DBD Yes None None a Yes No Yes 1a1, Direct HQ evidence Pratyush Das Sam Lambert Yes $#ENSG00000175727#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000312834#ENSG00000175727#ENST00000319080#bHLH#$#ENSP00000440769#ENSG00000175727#ENST00000538698#bHLH#$#ENSP00000438206#ENSG00000175727#ENST00000535430#bHLH#$#ENSP00000444507#ENSG00000175727#ENST00000542417#bHLH#$#ENSP00000445891#ENSG00000175727#ENST00000366272#bHLH# FALSE 98 ENSG00000009950 MLXIPL bHLH Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR011598; 51085 MLX interacting protein like [Source:HGNC Symbol;Acc:HGNC:12744] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific__PMIDS:0 Yes 1a1, Direct HQ evidence Pratyush Das Sam Lambert Yes $#ENSG00000009950#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000009950#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 | NAS - PMID:10780788 $#ENSP00000320886#ENSG00000009950#ENST00000313375#bHLH#$#ENSP00000346629#ENSG00000009950#ENST00000354613#bHLH#$#ENSP00000412330#ENSG00000009950#ENST00000414749#bHLH#$#ENSP00000406296#ENSG00000009950#ENST00000429400#bHLH#$#ENSP00000392636#ENSG00000009950#ENST00000434326#bHLH# FALSE 99 ENSG00000070444 MNT bHLH Yes Known motif Monomer or homomultimer High-throughput in vitro None Prefers to heterodimerize with MAX over homodimer formation (PMID: 9000049). IPR011598; 4335 MAX network transcriptional repressor [Source:HGNC Symbol;Acc:HGNC:7188] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; TF PPI_PMIDS:9184233 Yes 1a1, Direct HQ evidence Arttu Jolma Pratyush Das Yes $#ENSG00000070444#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IDA - PMID:9184233$#ENSG00000070444#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:9184233 $#ENSP00000174618#ENSG00000070444#ENST00000174618#bHLH#$#ENSP00000476269#ENSG00000070444#ENST00000575394#bHLH# FALSE 100 ENSG00000178860 MSC bHLH Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR011598; 9242 musculin [Source:HGNC Symbol;Acc:HGNC:7321] None DBD and Full Yes None None a Yes TF Gene Candidate_Transcription Factor Binding: tf co-factor binding; DNA-Binding: sequence-specific_DNA Binding; TF PPI_PMIDS:9892671 Yes 1a1, Direct HQ evidence Sam Lambert Laura Campitelli Yes $#ENSG00000178860#GO:0001206#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involv#IEA - GO_REF:0000019$#ENSG00000178860#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:9584154 $#ENSP00000321445#ENSG00000178860#ENST00000325509#bHLH# FALSE 101 ENSG00000151379 MSGN1 bHLH Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR011598; 343930 mesogenin 1 [Source:HGNC Symbol;Acc:HGNC:14907] None DBD Yes None None c Yes No Yes 1a1, Direct HQ evidence Matt Weirauch Arttu Jolma Yes $#ENSG00000151379#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IEA - GO_REF:0000019 $#ENSP00000281047#ENSG00000151379#ENST00000281047#bHLH# FALSE 102 ENSG00000059728 MXD1 bHLH Yes Inferred motif Obligate heteromer In vivo/Misc source None All three MXD proteins have very similar sequences and should behave accordingly, making heterodimers with at least MAX (PMID:8521822). IPR011598; 4084 MAX dimerization protein 1 [Source:HGNC Symbol;Acc:HGNC:6761] 1NLW DBD and Full Yes Obligate_Multimer Structure has MXD1-MAX heterodimer; PMID:12553908 for MXD1-MAX heterodimer 1NLW a Yes TF Gene_DNA-Binding: sequence-specific_Co-activation; DNA Binding_PMIDS:8816491 Yes 1a1, Direct HQ evidence Sam Lambert Jussi Taipale Yes $#ENSG00000059728#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:10723141$#ENSG00000059728#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:7829091, PMID:8425218 $#ENSP00000264444#ENSG00000059728#ENST00000264444#bHLH#$#ENSP00000443935#ENSG00000059728#ENST00000540449#bHLH#$#ENSP00000410672#ENSG00000059728#ENST00000435990#bHLH# FALSE 103 ENSG00000213347 MXD3 bHLH Yes Inferred motif Obligate heteromer In vivo/Misc source None All three MXD proteins have very similar sequences and should behave accordingly, making heterodimers with at least MAX (PMID:8521822). IPR011598; 83463 MAX dimerization protein 3 [Source:HGNC Symbol;Acc:HGNC:14008] None DBD Yes Obligate_Multimer heterodimerizes with MAX a Yes No No 3a, decent circumstantial evidence for its role as Sam Lambert Pratyush Das Yes None $#ENSP00000401867#ENSG00000213347#ENST00000439742#bHLH#$#ENSP00000389716#ENSG00000213347#ENST00000423571#bHLH#$#ENSP00000416921#ENSG00000213347#ENST00000427908#bHLH#$#ENSP00000425029#ENSG00000213347#ENST00000502529#bHLH# FALSE 104 ENSG00000123933 MXD4 bHLH Yes Inferred motif Obligate heteromer In vivo/Misc source None All three MXD proteins have very similar sequences and should behave accordingly, making heterodimers with at least MAX (PMID:8521822). IPR011598; 100616358 MAX dimerization protein 4 [Source:HGNC Symbol;Acc:HGNC:13906] None DBD and Full Yes None heterodimerizes with MAX a Yes No No 3a, decent circumstantial evidence for its role as Tim Hughes Arttu Jolma Yes None $#ENSP00000337889#ENSG00000123933#ENST00000337190#bHLH#Myc-LZ FALSE 105 ENSG00000119950 MXI1 bHLH Yes Known motif Obligate heteromer In vivo/Misc source Has a putative AT-hook Obligate heteromer (PMID: 8425219). IPR011598; 4601 MAX interactor 1, dimerization protein [Source:HGNC Symbol;Acc:HGNC:7534] None DBD and Full Yes Obligate_Multimer PMID:8425219, Heterodimerizes with MAX a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:8425219;15467743 No 2a1, Lower confidence direct evidence Yimeng Yin Matt Weirauch Yes None $#ENSP00000239007#ENSG00000119950#ENST00000239007#bHLH#$#ENSP00000331152#ENSG00000119950#ENST00000332674#bHLH#$#ENSP00000354606#ENSG00000119950#ENST00000361248#bHLH#$#ENSP00000376842#ENSG00000119950#ENST00000393134#bHLH#$#ENSP00000358625#ENSG00000119950#ENST00000369612#bHLH# FALSE 106 ENSG00000136997 MYC bHLH Yes Known motif Obligate heteromer In vivo/Misc source None Functions as a heterodimer with MAX. IPR002418;IPR003327;IPR011598;IPR012682 4609 v-myc avian myelocytomatosis viral oncogene homolog [Source:HGNC Symbol;Acc:HGNC:7553] 1NKP DBD and Full Yes Obligate_Multimer Structure has MYC-MAX heterodimer; PMID:12553908 for MYC-MAX crystal structure, well established to make heterodimers with bHLH:s such as MAX a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:12177005;16287840;16767079 Yes 1a1, Direct HQ evidence Jussi Taipale Pratyush Das Yes $#ENSG00000136997#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:10723141$#ENSG00000136997#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:9924025 $#ENSP00000259523#ENSG00000136997#ENST00000259523#bHLH#Myc_N$#ENSP00000367207#ENSG00000136997#ENST00000377970#bHLH#Myc_N, TRH$#ENSP00000429441#ENSG00000136997#ENST00000517291#bHLH#Myc_N$#ENSP00000430235#ENSG00000136997#ENST00000524013#bHLH#Myc_N, TRH$#ENSP00000479618#ENSG00000136997#ENST00000613283#bHLH#Myc_N, TRH$#ENSP00000478887#ENSG00000136997#ENST00000621592#bHLH#Myc_N, TRH$#ENSP00000430226#ENSG00000136997#ENST00000520751#bHLH# FALSE 107 ENSG00000116990 MYCL bHLH Yes Inferred motif Obligate heteromer In vivo/Misc source None Similar to MYC and thus likely to functions as a heterodimer with MAX. IPR002418;IPR011598;IPR012682; 4610 v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog [Source:HGNC Symbol;Acc:H None DBD and Full Yes None Mycn ChIP-seq makes sense, likely makes a heterodimer with MAX lice MYC b Yes No No 2a2, orthologous lower confidence evidence Arttu Jolma Pratyush Das Yes $#ENSG00000116990#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002 $#ENSP00000361902#ENSG00000116990#ENST00000372815#bHLH#Myc_N$#ENSP00000380494#ENSG00000116990#ENST00000397332#bHLH#Myc_N$#ENSP00000361903#ENSG00000116990#ENST00000372816#bHLH#Myc_N$#ENSP00000434375#ENSG00000116990#ENST00000450953#bHLH#Myc_N FALSE 108 ENSG00000134323 MYCN bHLH Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR002418;IPR011598;IPR012682; 4613 v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog [Source:HGNC Symbol;Acc:HG None DBD and Full Yes None None a Yes TF Gene Candidate_DNA-Binding: sequence-specific_DNA Binding_PMIDS:17124508 Yes 1a1, Direct HQ evidence Pratyush Das Sam Lambert Yes $#ENSG00000134323#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002 $#ENSP00000281043#ENSG00000134323#ENST00000281043#bHLH#CENP-B_dimeris, LRS4, Myc_N FALSE 109 ENSG00000111049 MYF5 bHLH Yes Known motif Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain None IPR002546;IPR011598;IPR022032; 4617 myogenic factor 5 [Source:HGNC Symbol;Acc:HGNC:7565] None DBD and Full Yes Obligate_Multimer PMID:16099183, heterodimerizes with TCF3, TCF4 and TCF12 a Yes TF Gene Candidate_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:2385294;15497153 Yes 2a1, Lower confidence direct evidence Yimeng Yin Pratyush Das Yes $#ENSG00000111049#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IBA - GO_REF:0000033$#ENSG00000111049#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#TAS - PMID:2311584 $#ENSP00000228644#ENSG00000111049#ENST00000228644#bHLH#Basic, Myf5 FALSE 110 ENSG00000111046 MYF6 bHLH Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR002546;IPR011598 4618 myogenic factor 6 [Source:HGNC Symbol;Acc:HGNC:7566] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_Transactivation_PMIDS:1317551;2311584;11076940 Yes 1a1, Direct HQ evidence Sam Lambert Pratyush Das Yes $#ENSG00000111046#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IBA - GO_REF:0000033$#ENSG00000111046#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:2311584$#ENSG00000111046#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000228641#ENSG00000111046#ENST00000228641#bHLH#Basic, Myf5 FALSE 111 ENSG00000129152 MYOD1 bHLH Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR002546;IPR011598;IPR022032; 4654 myogenic differentiation 1 [Source:HGNC Symbol;Acc:HGNC:7611] 1MDY DBD and Full Yes None Structure is MYOD1 homodimer a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:12242286 Yes 1a1, Direct HQ evidence Yimeng Yin Matt Weirauch Yes $#ENSG00000129152#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IDA - PMID:11076940$#ENSG00000129152#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#TAS - PMID:1846704 $#ENSP00000250003#ENSG00000129152#ENST00000250003#bHLH#Basic, Myf5 FALSE 112 ENSG00000122180 MYOG bHLH Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR002546;IPR011598 4656 myogenin [Source:HGNC Symbol;Acc:HGNC:7612] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:10733231 Yes 1a1, Direct HQ evidence Laura Campitelli Matt Weirauch Yes $#ENSG00000122180#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000122180#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IDA - PMID:11076940 | TAS - PMID:19783823$#ENSG00000122180#GO:0003700#sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024$#ENSG00000122180#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000241651#ENSG00000122180#ENST00000241651#bHLH#Basic FALSE 113 ENSG00000084676 NCOA1 bHLH Yes Likely to be sequence specific TF Obligate heteromer No motif None NCOA1/2/3 all have been tested on PBMs and HT-SELEX without yielding a motif. All are co-activators, collectively suggesting they might be obligate heteromers. IPR000014;IPR009110;IPR010011;IPR011598;IPR013767;IPR014920;IPR014935;IPR017426 8648 nuclear receptor coactivator 1 [Source:HGNC Symbol;Acc:HGNC:7668] None DBD and Full Yes None None c Yes TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:9192892 No 4a, two or more datasets predict it as a TF Tim Hughes Sam Lambert Yes None $#ENSP00000288599#ENSG00000084676#ENST00000288599#bHLH#DUF1518, DUF4927, NCOA_u2, Nuc_rec_co-act, PAS, PA$#ENSP00000320940#ENSG00000084676#ENST00000348332#bHLH#DUF1518, DUF4927, NCOA_u2, Nuc_rec_co-act, PAS, PA$#ENSP00000379197#ENSG00000084676#ENST00000395856#bHLH#DUF1518, DUF4927, NCOA_u2, Nuc_rec_co-act, PAS, PA$#ENSP00000385195#ENSG00000084676#ENST00000407230#bHLH#DUF1518, DUF4927, NCOA_u2, Nuc_rec_co-act, PAS_11, FALSE 114 ENSG00000140396 NCOA2 bHLH Yes Likely to be sequence specific TF Obligate heteromer No motif None NCOA1/2/3 all have been tested on PBMs and HT-SELEX without yielding a motif. All are co-activators, collectively suggesting they might be obligate heteromers. IPR000014;IPR009110;IPR010011;IPR011598;IPR013767;IPR014920;IPR014935;IPR017426 10499 nuclear receptor coactivator 2 [Source:HGNC Symbol;Acc:HGNC:7669] 3DZU DBD and Full Yes None The crystal has only a small peptide fragment of NCOA2 x No TF Gene_Transcription Factor Binding: tf co-factor binding_Co-activation_PMIDS:14662770;15983373 No 3a, decent circumstantial evidence for its role as Matt Weirauch Arttu Jolma Yes None $#ENSP00000399968#ENSG00000140396#ENST00000452400#bHLH#DUF1518, DUF4927, NCOA_u2, Nuc_rec_co-act, PAS, PA$#ENSP00000429132#ENSG00000140396#ENST00000518363#bHLH#DUF1518, Nuc_rec_co-act$#ENSP00000430850#ENSG00000140396#ENST00000520416#bHLH#$#ENSP00000430348#ENSG00000140396#ENST00000519724#bHLH# FALSE 115 ENSG00000124151 NCOA3 bHLH Yes Likely to be sequence specific TF Obligate heteromer No motif None NCOA1/2/3 all have been tested on PBMs and HT-SELEX without yielding a motif. All are co-activators, collectively suggesting they might be obligate heteromers. IPR000014;IPR009110;IPR010011;IPR011598;IPR013767;IPR014920;IPR014935;IPR017426 8202 nuclear receptor coactivator 3 [Source:HGNC Symbol;Acc:HGNC:7670] None DBD and Full Yes None None c Yes TF Gene_Transcription Factor Binding: tf co-factor binding_Co-activation_PMIDS:9192892 No 4a, two or more datasets predict it as a TF Pratyush Das Jussi Taipale Yes None $#ENSP00000361065#ENSG00000124151#ENST00000371997#bHLH#DUF1518, DUF4927, NCOA_u2, Nuc_rec_co-act, PAS, PA$#ENSP00000361066#ENSG00000124151#ENST00000371998#bHLH#DUF1518, DUF4927, NCOA_u2, Nuc_rec_co-act, PAS, PA$#ENSP00000361073#ENSG00000124151#ENST00000372004#bHLH#DUF1518, DUF4927, NCOA_u2, Nuc_rec_co-act, PAS, PA FALSE 116 ENSG00000162992 NEUROD1 bHLH Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR011598;IPR016637;IPR022575; 4760 neuronal differentiation 1 [Source:HGNC Symbol;Acc:HGNC:7762] 2QL2 DBD and Full Yes None Structure is heterodimer NEUROD1 - TCF3 a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:9111329;9343431 Yes 1a1, Direct HQ evidence Jussi Taipale Pratyush Das Yes $#ENSG00000162992#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000162992#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:10545951$#ENSG00000162992#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:14752053 $#ENSP00000295108#ENSG00000162992#ENST00000295108#bHLH#DNA_pol_phi, Neuro_bHLH FALSE 117 ENSG00000171532 NEUROD2 bHLH Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR011598;IPR016637;IPR022575; 4761 neuronal differentiation 2 [Source:HGNC Symbol;Acc:HGNC:7763] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:8816493;10098882;10871374 Yes 1a1, Direct HQ evidence Arttu Jolma Jussi Taipale Yes $#ENSG00000171532#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IEA - GO_REF:0000019$#ENSG00000171532#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:8816493$#ENSG00000171532#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024 $#ENSP00000306754#ENSG00000171532#ENST00000302584#bHLH#Neuro_bHLH FALSE 118 ENSG00000123307 NEUROD4 bHLH Yes Inferred motif Monomer or homomultimer High-throughput in vitro None None IPR011598;IPR016637;IPR022575; 58158 neuronal differentiation 4 [Source:HGNC Symbol;Acc:HGNC:13802] None DBD and Full Yes None NEUROD1 makes heterodimer with TCF3 (PDB:2QL2), maybe the other NEURO:s do the same b Yes TF Gene Candidate__Co-activation; Transactivation_PMIDS:12947105 No 1a2, Orthologous HQ evidence Yimeng Yin Matt Weirauch Yes None $#ENSP00000242994#ENSG00000123307#ENST00000242994#bHLH#Neuro_bHLH FALSE 119 ENSG00000164600 NEUROD6 bHLH Yes Inferred motif Monomer or homomultimer High-throughput in vitro None None IPR011598;IPR016637;IPR022575; 63974 neuronal differentiation 6 [Source:HGNC Symbol;Acc:HGNC:13804] None DBD and Full Yes None NEUROD1 makes heterodimer with TCF3 (PDB:2QL2), maybe the other NEURO:s do the same a Yes TF Gene_DNA-Binding: sequence-specific_Other_PMIDS:9308961;9454850;12562512 Yes 1a2, Orthologous HQ evidence Sam Lambert Yimeng Yin Yes $#ENSG00000164600#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019 $#ENSP00000297142#ENSG00000164600#ENST00000297142#bHLH#Neuro_bHLH FALSE 120 ENSG00000181965 NEUROG1 bHLH Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR011598; 4762 neurogenin 1 [Source:HGNC Symbol;Acc:HGNC:7764] None DBD and Full Yes None None a Yes TF Gene Candidate_DNA-Binding: sequence-specific_Transactivation_PMIDS:10814830 Yes 1a1, Direct HQ evidence Jussi Taipale Laura Campitelli Yes $#ENSG00000181965#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:8816493$#ENSG00000181965#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024 $#ENSP00000317580#ENSG00000181965#ENST00000314744#bHLH# FALSE 121 ENSG00000178403 NEUROG2 bHLH Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR011598; 63973 neurogenin 2 [Source:HGNC Symbol;Acc:HGNC:13805] None DBD and Full Yes None None c Yes No Yes 1a1, Direct HQ evidence Jussi Taipale Laura Campitelli Yes $#ENSG00000178403#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024 $#ENSP00000317333#ENSG00000178403#ENST00000313341#bHLH# FALSE 122 ENSG00000122859 NEUROG3 bHLH Yes Inferred motif Monomer or homomultimer High-throughput in vitro None None IPR011598; 50674 neurogenin 3 [Source:HGNC Symbol;Acc:HGNC:13806] None DBD and Full Yes None PMID:19389376 Ascl1 and Neurog2 make DNA-binding complexes, maybe this paralog behaves like it a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:10757813;16511571;10757813;16511571;16511571;14576336;16511571 Yes 1a2, Orthologous HQ evidence Pratyush Das Matt Weirauch Yes $#ENSG00000122859#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000122859#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:14576336$#ENSG00000122859#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024 $#ENSP00000242462#ENSG00000122859#ENST00000242462#bHLH# FALSE 123 ENSG00000171786 NHLH1 bHLH Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR011598; 4807 nescient helix-loop-helix 1 [Source:HGNC Symbol;Acc:HGNC:7817] None DBD and Full Yes None None b Yes No Yes 1a1, Direct HQ evidence Arttu Jolma Laura Campitelli Yes $#ENSG00000171786#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IDA - PMID:12878195 $#ENSP00000302189#ENSG00000171786#ENST00000302101#bHLH# FALSE 124 ENSG00000177551 NHLH2 bHLH Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR011598; 4808 nescient helix-loop-helix 2 [Source:HGNC Symbol;Acc:HGNC:7818] None DBD and Full Yes None None b Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:15470499 Yes 1a1, Direct HQ evidence Yimeng Yin Pratyush Das Yes $#ENSG00000177551#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000177551#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#TAS - PMID:16314316 $#ENSP00000322087#ENSG00000177551#ENST00000320238#bHLH#$#ENSP00000405062#ENSG00000177551#ENST00000429731#bHLH#$#ENSP00000358519#ENSG00000177551#ENST00000369506#bHLH# FALSE 125 ENSG00000130751 NPAS1 bHLH Yes Inferred motif Obligate heteromer In vivo/Misc source None Likely obligate heteromer (PMID: 27782878). IPR000014;IPR011598;IPR013655;IPR013767 4861 neuronal PAS domain protein 1 [Source:HGNC Symbol;Acc:HGNC:7894] None DBD and Full Yes None Taipale lab has an unpublished PWM a Yes TF Gene_DNA-Binding: non-sequence-specific_Non-specific DNA_PMIDS:15635607 Yes 1a1, Direct HQ evidence Laura Campitelli Sam Lambert Yes $#ENSG00000130751#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000130751#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:9012850 $#ENSP00000405290#ENSG00000130751#ENST00000449844#bHLH#PAS, PAS_11, PAS_3, PAS_4, PAS_9$#ENSP00000469142#ENSG00000130751#ENST00000602212#bHLH#PAS, PAS_11, PAS_3, PAS_4, PAS_9$#ENSP00000398689#ENSG00000130751#ENST00000439365#bHLH#PAS_11, PAS_3 FALSE 126 ENSG00000170485 NPAS2 bHLH Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000014;IPR001067;IPR001610;IPR011598;IPR013767; 4862 neuronal PAS domain protein 2 [Source:HGNC Symbol;Acc:HGNC:7895] None DBD and Full Yes None PMID:10864977 ARNTL2 Forms heterodimer with NPAS2 a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:11441146 Yes 1a1, Direct HQ evidence Sam Lambert Jussi Taipale Yes $#ENSG00000170485#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002 $#ENSP00000338283#ENSG00000170485#ENST00000335681#bHLH#PAS, PAS_11, PAS_3, PAS_9$#ENSP00000397595#ENSG00000170485#ENST00000427413#bHLH#PAS, PAS_9$#ENSP00000395265#ENSG00000170485#ENST00000451740#bHLH#PAS$#ENSP00000392125#ENSG00000170485#ENST00000450763#bHLH# FALSE 127 ENSG00000151322 NPAS3 bHLH Yes Inferred motif Obligate heteromer In vivo/Misc source None Likely obligate heteromer (PMID: 9374395; PMID: 27782878). IPR000014;IPR011598;IPR013655;IPR013767 64067 neuronal PAS domain protein 3 [Source:HGNC Symbol;Acc:HGNC:19311] None DBD Yes None None c Yes TF Gene Candidate_DNA-Binding: sequence-specific_Other_PMIDS:16172381;9374395;16172381;10534623;16172381;16190882 Yes 1a2, Orthologous HQ evidence Matt Weirauch Pratyush Das Yes $#ENSG00000151322#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000319610#ENSG00000151322#ENST00000346562#bHLH#PAS, PAS_11, PAS_3, PAS_4, PAS_9$#ENSP00000348460#ENSG00000151322#ENST00000356141#bHLH#PAS, PAS_11, PAS_3, PAS_4, PAS_9$#ENSP00000350446#ENSG00000151322#ENST00000357798#bHLH#PAS, PAS_11, PAS_3, PAS_4, PAS_9$#ENSP00000449542#ENSG00000151322#ENST00000547068#bHLH#PAS, PAS_3$#ENSP00000448916#ENSG00000151322#ENST00000548645#bHLH#PAS, PAS_11, PAS_3, PAS_4, PAS_9$#ENSP00000447213#ENSG00000151322#ENST00000551008#bHLH#PAS, PAS_3$#ENSP00000446700#ENSG00000151322#ENST00000546849#bHLH#PAS FALSE 128 ENSG00000174576 NPAS4 bHLH Yes Inferred motif Obligate heteromer High-throughput in vitro None Likely dimerizes with ARNT2 (PMID:24263188). IPR000014;IPR011598;IPR013655; 266743 neuronal PAS domain protein 4 [Source:HGNC Symbol;Acc:HGNC:18983] None DBD Yes None Taipale lab has an unpublished PWM; review suggests that it forms heterodimer with ARNT2 PMID:24263188, NPAS4:ARNT2 other Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:14701734 Yes 1a1, Direct HQ evidence Jussi Taipale Arttu Jolma Yes $#ENSG00000174576#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IDA - PMID:24465693$#ENSG00000174576#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:14701734 $#ENSP00000311196#ENSG00000174576#ENST00000311034#bHLH#PAS, PAS_11, PAS_3 FALSE 129 ENSG00000184221 OLIG1 bHLH Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR011598; 116448 oligodendrocyte transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:16983] None DBD Yes None None a Yes TF Gene_DNA-Binding: sequence-specific; Transcription Factor Binding: tf co-factor binding_DNA Binding; TF PPI; Transactivation_PMIDS:18160645;15703389 No 1a1, Direct HQ evidence Sam Lambert Laura Campitelli Yes None $#ENSP00000414840#ENSG00000184221#ENST00000426947#bHLH#$#ENSP00000371785#ENSG00000184221#ENST00000382348#bHLH# FALSE 130 ENSG00000205927 OLIG2 bHLH Yes Known motif Monomer or homomultimer High-throughput in vitro None OLIG2 can homodimerize and heterodimerize with OLIG1 and NGN2 (PMID:15655114; PMID: 21382552). IPR011598; 10215 oligodendrocyte lineage transcription factor 2 [Source:HGNC Symbol;Acc:HGNC:9398] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific; Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:14576772;15655114 Yes 1a1, Direct HQ evidence Yimeng Yin Sam Lambert Yes $#ENSG00000205927#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019 $#ENSP00000371794#ENSG00000205927#ENST00000382357#bHLH#$#ENSP00000391183#ENSG00000205927#ENST00000430860#bHLH#$#ENSP00000331040#ENSG00000205927#ENST00000333337#bHLH# FALSE 131 ENSG00000177468 OLIG3 bHLH Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR011598; 167826 oligodendrocyte transcription factor 3 [Source:HGNC Symbol;Acc:HGNC:18003] None DBD and Full Yes None None b Yes Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0; No 1a1, Direct HQ evidence Yimeng Yin Jussi Taipale Yes None $#ENSP00000356708#ENSG00000177468#ENST00000367734#bHLH# FALSE 132 ENSG00000168267 PTF1A bHLH Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR011598; 256297 pancreas specific transcription factor, 1a [Source:HGNC Symbol;Acc:HGNC:23734] None DBD Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:2294404;11279116 No 1a1, Direct HQ evidence Sam Lambert Matt Weirauch Yes $#ENSG00000168267#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019 $#ENSP00000365687#ENSG00000168267#ENST00000376504#bHLH# FALSE 133 ENSG00000260428 SCX bHLH Yes Inferred motif Monomer or homomultimer High-throughput in vitro None SCX heterodimerizes with TCF3 (PMID: 19828133). The Taipale lab has an unpublished HT-SELEX model; both it and the inferred B1H motif seem very weak, supporting the idea that the homodimer does not bind DNA well. IPR011598; 642658 scleraxis bHLH transcription factor [Source:HGNC Symbol;Acc:HGNC:32322] None not tested not tested None Taipale lab has an unpublished PWM; PMID:19828133, SCX heterodimerizes with TCF3 x Yes TF Gene Candidate_Transcription Factor Binding: tf co-factor binding; DNA-Binding: sequence-specific_Co-activation_PMIDS:10775504;15831523 No 1a1, Direct HQ evidence Jussi Taipale Arttu Jolma Yes $#ENSG00000260428#GO:0001205#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involv#IEA - GO_REF:0000019 $#ENSP00000476384#ENSG00000260428#ENST00000567180#bHLH# FALSE 134 ENSG00000112246 SIM1 bHLH Yes Inferred motif Obligate heteromer In vivo/Misc source None Similar to SIM2, which is a likely obligate heteromer. IPR000014;IPR001610;IPR010578;IPR011598;IPR013655;IPR013767 6492 single-minded family bHLH transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:10882] None not tested Yes None From review PMID:24263188, SIM1:ARNT2 other Yes No Yes 1a2, Orthologous HQ evidence Sam Lambert Tim Hughes Yes $#ENSG00000112246#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000112246#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:8812055, PMID:9199934 $#ENSP00000262901#ENSG00000112246#ENST00000262901#bHLH#PAS, PAS_11, PAS_3, PAS_4, PAS_9, SIM_C$#ENSP00000358210#ENSG00000112246#ENST00000369208#bHLH#PAS, PAS_11, PAS_3, PAS_4, PAS_9, SIM_C FALSE 135 ENSG00000159263 SIM2 bHLH Yes Inferred motif Obligate heteromer In vivo/Misc source None Likely obligate hetereomer (PMID: 7592839) IPR000014;IPR001610;IPR010578;IPR011598;IPR013655;IPR013767 6493 single-minded family bHLH transcription factor 2 [Source:HGNC Symbol;Acc:HGNC:10883] None DBD and Full Yes None From review PMID:24263188, SIM2:ARNT2 other Yes TF Gene_DNA-Binding: non-sequence-specific; Transcription Factor Binding: tf co-factor binding_Co-activation_PMIDS:11782478 Yes 1a2, Orthologous HQ evidence Sam Lambert Matt Weirauch Yes $#ENSG00000159263#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000159263#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:8661114, PMID:9199934 $#ENSP00000290399#ENSG00000159263#ENST00000290399#bHLH#PAS, PAS_11, PAS_3, PAS_9, SIM_C$#ENSP00000392003#ENSG00000159263#ENST00000431229#bHLH#PAS, PAS_11, PAS_3, PAS_4, PAS_9, SIM_C$#ENSP00000476273#ENSG00000159263#ENST00000483178#bHLH#PAS, PAS_11, PAS_3 FALSE 136 ENSG00000165643 SOHLH1 bHLH Yes Likely to be sequence specific TF Obligate heteromer No motif None Forms SOHLH1-SOHLH2 heterodimers (PMID: 22056784). IPR011598; 402381 spermatogenesis and oogenesis specific basic helix-loop-helix 1 [Source:HGNC Symbol;Acc:HGNC:27845] None DBD and Full Yes None None a Yes No Yes 3a, decent circumstantial evidence for its role as Pratyush Das Arttu Jolma Yes $#ENSG00000165643#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IBA - GO_REF:0000033 $#ENSP00000298466#ENSG00000165643#ENST00000298466#bHLH#$#ENSP00000404438#ENSG00000165643#ENST00000425225#bHLH# FALSE 137 ENSG00000120669 SOHLH2 bHLH Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR011598; 54937 spermatogenesis and oogenesis specific basic helix-loop-helix 2 [Source:HGNC Symbol;Acc:HGNC:26026] None DBD Yes None None c Yes No Yes 1a1, Direct HQ evidence Tim Hughes Pratyush Das Yes $#ENSG00000120669#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IBA - GO_REF:0000033 $#ENSP00000326838#ENSG00000120669#ENST00000317764#bHLH#$#ENSP00000369210#ENSG00000120669#ENST00000379881#bHLH# FALSE 138 ENSG00000072310 SREBF1 bHLH Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR011598; 6720 sterol regulatory element binding transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:11289] 1AM9 DBD Yes None Structure is homodimer with the non E-box site a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:11829742 Yes 1a1, Direct HQ evidence Jussi Taipale Matt Weirauch Yes $#ENSG00000072310#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000072310#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:16407292 $#ENSP00000261646#ENSG00000072310#ENST00000261646#bHLH#$#ENSP00000348069#ENSG00000072310#ENST00000355815#bHLH#$#ENSP00000379106#ENSG00000072310#ENST00000395757#bHLH#$#ENSP00000411516#ENSG00000072310#ENST00000423161#bHLH#$#ENSP00000466453#ENSG00000072310#ENST00000486311#bHLH# FALSE 139 ENSG00000198911 SREBF2 bHLH Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR011598; 6721 sterol regulatory element binding transcription factor 2 [Source:HGNC Symbol;Acc:HGNC:11290] None DBD Yes None None a Yes TF Gene Candidate_DNA-Binding: sequence-specific_DNA Binding_PMIDS:7903453 Yes 1a1, Direct HQ evidence Sam Lambert Pratyush Das Yes $#ENSG00000198911#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:15358760 $#ENSP00000354476#ENSG00000198911#ENST00000361204#bHLH#$#ENSP00000412287#ENSG00000198911#ENST00000435061#bHLH#$#ENSP00000484441#ENSG00000198911#ENST00000612482#bHLH# FALSE 140 ENSG00000162367 TAL1 bHLH Yes Known motif Obligate heteromer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain No motif yielded from PBMs or HT-SELEX. Binds DNA as heterodimer with TCF3 (PDB:2YPB and PDB:2YPA). IPR011598; 6886 T-cell acute lymphocytic leukemia 1 [Source:HGNC Symbol;Acc:HGNC:11556] 2YPB DBD Yes Obligate_Multimer Obligate heterodimer with TCF3 pmid:23831025 b Yes TF Gene_DNA-Binding: sequence-specific_Transactivation_PMIDS:8016094;8289805 Yes 1a1, Direct HQ evidence Yimeng Yin Sam Lambert Yes $#ENSG00000162367#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000162367#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:19497860 $#ENSP00000294339#ENSG00000162367#ENST00000294339#bHLH#$#ENSP00000360951#ENSG00000162367#ENST00000371884#bHLH# FALSE 141 ENSG00000186051 TAL2 bHLH Yes Inferred motif Obligate heteromer In vivo/Misc source None No motif yielded from PBMs or HT-SELEX. Similar to TAL1, which binds DNA as heterodimer with TCF3 (PDB:2YPB and PDB:2YPA). IPR011598; 6887 T-cell acute lymphocytic leukemia 2 [Source:HGNC Symbol;Acc:HGNC:11557] None DBD and Full Yes None None b Yes TF Gene Candidate_DNA-Binding: sequence-specific_DNA Binding_PMIDS:8152805;11071772 Yes 2a2, orthologous lower confidence evidence Pratyush Das Sam Lambert Yes $#ENSG00000186051#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000334547#ENSG00000186051#ENST00000334077#bHLH# FALSE 142 ENSG00000140262 TCF12 bHLH Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR011598; 6938 transcription factor 12 [Source:HGNC Symbol;Acc:HGNC:11623] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:8163514;12826747 Yes 1a1, Direct HQ evidence Sam Lambert Pratyush Das Yes $#ENSG00000140262#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:11802795$#ENSG00000140262#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:11802795 $#ENSP00000267811#ENSG00000140262#ENST00000267811#bHLH#$#ENSP00000331057#ENSG00000140262#ENST00000333725#bHLH#$#ENSP00000342459#ENSG00000140262#ENST00000343827#bHLH#$#ENSP00000440017#ENSG00000140262#ENST00000543579#bHLH#$#ENSP00000453737#ENSG00000140262#ENST00000557843#bHLH#$#ENSP00000444696#ENSG00000140262#ENST00000537840#bHLH#$#ENSP00000453876#ENSG00000140262#ENST00000559609#bHLH#$#ENSP00000453264#ENSG00000140262#ENST00000559710#bHLH#$#ENSP00000456280#ENSG00000140262#ENST00000560948#bHLH#$#ENSP00000454823#ENSG00000140262#ENST00000560836#bHLH# FALSE 143 ENSG00000125878 TCF15 bHLH Yes Inferred motif Monomer or homomultimer High-throughput in vitro None None IPR011598; 6939 transcription factor 15 (basic helix-loop-helix) [Source:HGNC Symbol;Acc:HGNC:11627] None DBD Yes None None a Yes TF Gene Candidate_DNA-Binding: non-sequence-specific_DNA Binding_PMIDS:7597044 Yes 1a1, Direct HQ evidence Tim Hughes Laura Campitelli Yes $#ENSG00000125878#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:8041747, PMID:8825648 $#ENSP00000246080#ENSG00000125878#ENST00000246080#bHLH# FALSE 144 ENSG00000118526 TCF21 bHLH Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR011598; 6943 transcription factor 21 [Source:HGNC Symbol;Acc:HGNC:11632] None DBD Yes None None a Yes No Yes 1a1, Direct HQ evidence Laura Campitelli Yimeng Yin Yes $#ENSG00000118526#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#ISS - GO_REF:0000024$#ENSG00000118526#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:12493738 $#ENSP00000237316#ENSG00000118526#ENST00000237316#bHLH#$#ENSP00000356857#ENSG00000118526#ENST00000367882#bHLH# FALSE 145 ENSG00000163792 TCF23 bHLH Yes Inferred motif Monomer or homomultimer High-throughput in vitro None Basic region is very similar to TCF21, which binds DNA as a homodimer in HT-SELEX. IPR011598; 150921 transcription factor 23 [Source:HGNC Symbol;Acc:HGNC:18602] None DBD and Full Yes None Taipale lab has an unpublished PWM; PMID:10652346 Suggests that similarly to ID-proteins it seems to lack the ability to bind DNA and presumably works as an inhibitor that sequesters TCF3 c Yes Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0 No 1a1, Direct HQ evidence Sam Lambert Yimeng Yin Yes None $#ENSP00000296096#ENSG00000163792#ENST00000296096#bHLH# FALSE 146 ENSG00000261787 TCF24 bHLH Yes Inferred motif Monomer or homomultimer High-throughput in vitro None None None 100129654 Transcription factor 24 [Source:HGNC Symbol;Acc:HGNC:32275] None not tested not tested None None c Yes No No 4a, two or more datasets predict it as a TF Pratyush Das Sam Lambert No None $#ENSP00000455444#ENSG00000261787#ENST00000563496#bHLH# FALSE 147 ENSG00000071564 TCF3 bHLH Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR011598; 6929 transcription factor 3 [Source:HGNC Symbol;Acc:HGNC:11633] 2QL2 DBD and Full Yes None Structure is heterodimer NEUROD1 - TCF3 a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:14627819 Yes 1a1, Direct HQ evidence Tim Hughes Matt Weirauch Yes $#ENSG00000071564#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:14576336$#ENSG00000071564#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:2105528 | NAS - PMID:2493990$#ENSG00000071564#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:14752053 $#ENSP00000262965#ENSG00000071564#ENST00000262965#bHLH#$#ENSP00000480564#ENSG00000071564#ENST00000611869#bHLH#$#ENSP00000465510#ENSG00000071564#ENST00000585731#bHLH#$#ENSP00000467508#ENSG00000071564#ENST00000587425#bHLH#$#ENSP00000468487#ENSG00000071564#ENST00000588136#bHLH#$#ENSP00000468481#ENSG00000071564#ENST00000593064#bHLH#$#ENSP00000466954#ENSG00000071564#ENST00000586318#bHLH#$#ENSP00000466565#ENSG00000071564#ENST00000590684#bHLH# FALSE 148 ENSG00000196628 TCF4 bHLH Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR011598; 6925 transcription factor 4 [Source:HGNC Symbol;Acc:HGNC:11634] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; TF PPI; Transactivation_PMIDS:8978694 Yes 1a1, Direct HQ evidence Sam Lambert Pratyush Das Yes $#ENSG00000196628#GO:0001011#sequence-specific DNA binding RNA polymerase recruiting transcription factor activity#ISS - PMID:8978694$#ENSG00000196628#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#ISS - PMID:8978694$#ENSG00000196628#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:11802795, PMID:2105528 $#ENSP00000348374#ENSG00000196628#ENST00000356073#bHLH#$#ENSP00000381382#ENSG00000196628#ENST00000398339#bHLH#$#ENSP00000409447#ENSG00000196628#ENST00000457482#bHLH#$#ENSP00000439656#ENSG00000196628#ENST00000543082#bHLH#$#ENSP00000457765#ENSG00000196628#ENST00000561831#bHLH#$#ENSP00000455450#ENSG00000196628#ENST00000562543#bHLH#$#ENSP00000456802#ENSG00000196628#ENST00000562638#bHLH#$#ENSP00000455261#ENSG00000196628#ENST00000564228#bHLH#$#ENSP00000455418#ENSG00000196628#ENST00000566286#bHLH#$#ENSP00000454366#ENSG00000196628#ENST00000567880#bHLH#$#ENSP00000455763#ENSG00000196628#ENST00000570287#bHLH#$#ENSP00000440731#ENSG00000196628#ENST00000537578#bHLH#$#ENSP00000439827#ENSG00000196628#ENST00000537856#bHLH#$#ENSP00000445202#ENSG00000196628#ENST00000540999#bHLH#$#ENSP00000441562#ENSG00000196628#ENST00000544241#bHLH#$#ENSP00000455179#ENSG00000196628#ENST00000561992#bHLH#$#ENSP00000458122#ENSG00000196628#ENST00000568186#bHLH#$#ENSP00000468729#ENSG00000196628#ENST00000570146#bHLH#$#ENSP00000454647#ENSG00000196628#ENST00000570177#bHLH#$#ENSP00000487505#ENSG00000196628#ENST00000626631#bHLH#$#ENSP00000486974#ENSG00000196628#ENST00000630828#bHLH#$#ENSP00000454866#ENSG00000196628#ENST00000562847#bHLH#$#ENSP00000454584#ENSG00000196628#ENST00000565908#bHLH#$#ENSP00000456983#ENSG00000196628#ENST00000566514#bHLH#$#ENSP00000487419#ENSG00000196628#ENST00000630712#bHLH#$#ENSP00000490451#ENSG00000196628#ENST00000635822#bHLH#$#ENSP00000490006#ENSG00000196628#ENST00000636400#bHLH#$#ENSP00000490883#ENSG00000196628#ENST00000636822#bHLH#$#ENSP00000490832#ENSG00000196628#ENST00000637169#bHLH#$#ENSP00000490625#ENSG00000196628#ENST00000638154#bHLH# FALSE 149 ENSG00000101190 TCFL5 bHLH Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR011598; 10732 transcription factor like 5 [Source:HGNC Symbol;Acc:HGNC:11646] None DBD and Full Yes None None a Yes No Yes 1a1, Direct HQ evidence Yimeng Yin Sam Lambert Yes $#ENSG00000101190#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:9763657 $#ENSP00000217162#ENSG00000101190#ENST00000217162#bHLH#$#ENSP00000334294#ENSG00000101190#ENST00000335351#bHLH# FALSE 150 ENSG00000090447 TFAP4 bHLH Yes Known motif Monomer or homomultimer High-throughput in vitro None Also can form heterodimers (PMID: 26550823). IPR011598; 7023 transcription factor AP-4 (activating enhancer binding protein 4) [Source:HGNC Symbol;Acc:HGNC:11745 None DBD and Full not tested None None a Yes TF Gene Candidate_DNA-Binding: sequence-specific_DNA Binding_PMIDS:2123466;2833704 Yes 1a1, Direct HQ evidence Pratyush Das Matt Weirauch Yes $#ENSG00000090447#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000090447#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#IDA - PMID:2833704 $#ENSP00000204517#ENSG00000090447#ENST00000204517#bHLH#$#ENSP00000459390#ENSG00000090447#ENST00000572393#bHLH# FALSE 151 ENSG00000068323 TFE3 bHLH Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR011598;IPR021802 7030 transcription factor binding to IGHM enhancer 3 [Source:HGNC Symbol;Acc:HGNC:11752] None DBD not tested None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:10707962;15994295 Yes 1a1, Direct HQ evidence Tim Hughes Arttu Jolma Yes $#ENSG00000068323#GO:0003700#sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024 $#ENSP00000314129#ENSG00000068323#ENST00000315869#bHLH#DUF3371, MITF_TFEB_C_3_N FALSE 152 ENSG00000112561 TFEB bHLH Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR011598;IPR021802 7942 transcription factor EB [Source:HGNC Symbol;Acc:HGNC:11753] None DBD and Full Yes None None a Yes Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0 Yes 1a1, Direct HQ evidence Sam Lambert Arttu Jolma Yes $#ENSG00000112561#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:19556463 | NAS - PMID:2115126 $#ENSP00000230323#ENSG00000112561#ENST00000230323#bHLH#DUF3371, MITF_TFEB_C_3_N$#ENSP00000351742#ENSG00000112561#ENST00000358871#bHLH#DUF3371, MITF_TFEB_C_3_N$#ENSP00000362124#ENSG00000112561#ENST00000373033#bHLH#DUF3371, MITF_TFEB_C_3_N$#ENSP00000383998#ENSG00000112561#ENST00000406563#bHLH#DUF3371$#ENSP00000396168#ENSG00000112561#ENST00000424495#bHLH#MITF_TFEB_C_3_N$#ENSP00000415035#ENSG00000112561#ENST00000425401#bHLH#MITF_TFEB_C_3_N$#ENSP00000415946#ENSG00000112561#ENST00000433032#bHLH#$#ENSP00000395208#ENSG00000112561#ENST00000445700#bHLH#$#ENSP00000343948#ENSG00000112561#ENST00000343317#bHLH#DUF3371, MITF_TFEB_C_3_N$#ENSP00000377824#ENSG00000112561#ENST00000394283#bHLH#MITF_TFEB_C_3_N$#ENSP00000400276#ENSG00000112561#ENST00000419574#bHLH#MITF_TFEB_C_3_N FALSE 153 ENSG00000105967 TFEC bHLH Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR011598;IPR021802 22797 transcription factor EC [Source:HGNC Symbol;Acc:HGNC:11754] None DBD and Full Yes None None a Yes TF Gene Candidate_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:8336698 Yes 1a1, Direct HQ evidence Yimeng Yin Arttu Jolma Yes $#ENSG00000105967#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:9256061 $#ENSP00000265440#ENSG00000105967#ENST00000265440#bHLH#DUF3371$#ENSP00000318676#ENSG00000105967#ENST00000320239#bHLH#DUF3371$#ENSP00000377125#ENSG00000105967#ENST00000393485#bHLH#$#ENSP00000417432#ENSG00000105967#ENST00000484212#bHLH#MITF_TFEB_C_3_N$#ENSP00000387650#ENSG00000105967#ENST00000457268#bHLH#DUF3371 FALSE 154 ENSG00000122691 TWIST1 bHLH Yes Known motif Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain Can form both homodimers and heterodimers with TCF3 (PMID: 16502419). IPR011598; 7291 twist family bHLH transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:12428] None DBD Yes Obligate_Multimer PMID: 16502419, reported to be able to make both homo- or heterodimers with TCF3 a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:12210745 Yes 2a1, Lower confidence direct evidence Jussi Taipale Matt Weirauch Yes $#ENSG00000122691#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IDA - PMID:17332325$#ENSG00000122691#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019 $#ENSP00000242261#ENSG00000122691#ENST00000242261#bHLH# FALSE 155 ENSG00000233608 TWIST2 bHLH Yes Known motif Monomer or homomultimer 100 perc ID - in vitro None None IPR011598; 117581 twist family bHLH transcription factor 2 [Source:HGNC Symbol;Acc:HGNC:20670] None not tested Yes None TFs that are in CisBP but not in Vaquerizas set No Yes TF Gene_Transcription Factor Binding: tf co-factor binding; DNA-Binding: sequence-specific_Other; TF PPI_PMIDS:11809751;14654692 No 1a1, Direct HQ evidence Yimeng Yin Sam Lambert Yes None $#ENSP00000405176#ENSG00000233608#ENST00000448943#bHLH#$#ENSP00000482581#ENSG00000233608#ENST00000612363#bHLH# FALSE 156 ENSG00000158773 USF1 bHLH Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR011598; 7391 upstream transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:12593] 1AN4 DBD and Full Yes None Structure is a homodimer a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:9677331 Yes 1a1, Direct HQ evidence Laura Campitelli Arttu Jolma Yes $#ENSG00000158773#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#IDA - PMID:2249772 | IMP - PMID:18234320, PMID:857 $#ENSP00000356999#ENSG00000158773#ENST00000368020#bHLH#$#ENSP00000357000#ENSG00000158773#ENST00000368021#bHLH#$#ENSP00000433041#ENSG00000158773#ENST00000528768#bHLH# FALSE 157 ENSG00000105698 USF2 bHLH Yes Known motif Monomer or homomultimer High-throughput in vitro Has a putative AT-hook None IPR011598; 7392 upstream transcription factor 2, c-fos interacting [Source:HGNC Symbol;Acc:HGNC:12594] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:15242350 Yes 1a1, Direct HQ evidence Matt Weirauch Sam Lambert Yes $#ENSG00000105698#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:1589769, PMID:8954795$#ENSG00000105698#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#IMP - PMID:8576131 $#ENSP00000222305#ENSG00000105698#ENST00000222305#bHLH#$#ENSP00000340633#ENSG00000105698#ENST00000343550#bHLH#$#ENSP00000368429#ENSG00000105698#ENST00000379134#bHLH#$#ENSP00000471511#ENSG00000105698#ENST00000594064#bHLH#$#ENSP00000469585#ENSG00000105698#ENST00000598058#bHLH#$#ENSP00000470081#ENSG00000105698#ENST00000599625#bHLH#$#ENSP00000471775#ENSG00000105698#ENST00000596380#bHLH#$#ENSP00000469364#ENSG00000105698#ENST00000599471#bHLH# FALSE 158 ENSG00000176542 USF3 bHLH Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR011598; 205717 None None DBD not tested None None c Yes No No 4a, two or more datasets predict it as a TF Pratyush Das Sam Lambert No None $#ENSP00000420752#ENSG00000176542#ENST00000491165#bHLH#$#ENSP00000320794#ENSG00000176542#ENST00000316407#bHLH#$#ENSP00000420721#ENSG00000176542#ENST00000478658#bHLH# FALSE 159 ENSG00000143157 POGK Brinker Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR001909;IPR004875;IPR006600;IPR009057;IPR018586; 57645 pogo transposable element with KRAB domain [Source:HGNC Symbol;Acc:HGNC:18800] None Full Yes None None x Yes No No 4a, two or more datasets predict it as a TF Sam Lambert Arttu Jolma No None $#ENSP00000356850#ENSG00000143157#ENST00000367876#Brinker#DDE_1, HTH_Tnp_Tc5, KRAB$#ENSP00000404402#ENSG00000143157#ENST00000449930#Brinker#KRAB$#ENSP00000356849#ENSG00000143157#ENST00000367875#Brinker#DDE_1, HTH_Tnp_Tc5, KRAB FALSE 160 ENSG00000267281 AC023509.3 bZIP Yes Known motif Monomer or homomultimer 100 perc ID - in vitro None Identical bZIP DBD to ATF7. Some isoforms also contain a single C2H2 ZF. This is known to facilitate protein interactions in ATF7 (see ATF7 Uniprot page), so AC023509.3 is only classified here as a bZIP protein None None Uncharacterized protein None not tested not tested None None No Yes No Yes 4a, two or more datasets predict it as a TF Yimeng Yin Pratyush Das No $#ENSG00000267281#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002 $##ENSG00000267281##bZIP# FALSE 161 ENSG00000115266 APC2 bZIP No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Based on the alignments, the protein is only weakly related to the other bZIP proteins and lacks the basic region required for DNA binding IPR000225;IPR009223;IPR009224;IPR009234;IPR016024;IPR026831 10297 adenomatosis polyposis coli 2 [Source:HGNC Symbol;Acc:HGNC:24036] None not tested not tested None None No Yes No No 5a, one of the source datasets predicts is as a TF Arttu Jolma Jussi Taipale No None $#ENSP00000233607#ENSG00000115266#ENST00000233607#bZIP#APC_N_CC, APC_basic, APC_r, Arm, Arm_APC_u3, SAMP,$#ENSP00000238483#ENSG00000115266#ENST00000238483#bZIP#APC_N_CC, Arm, Arm_APC_u3, Suppressor_APC, ZapB$#ENSP00000442954#ENSG00000115266#ENST00000535453#bZIP#APC_N_CC, APC_basic, APC_r, Arm, Arm_APC_u3, SAMP,$#ENSP00000467073#ENSG00000115266#ENST00000590469#bZIP#APC_N_CC, Arm, Suppressor_APC, ZapB$#ENSP00000466173#ENSG00000115266#ENST00000590877#bZIP#Suppressor_APC FALSE 162 ENSG00000123268 ATF1 bZIP Yes Known motif Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain None IPR001630;IPR003102;IPR004827; 466 activating transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:783] None DBD and Full Yes None None a Yes No Yes 1a1, Direct HQ evidence Tim Hughes Sam Lambert Yes $#ENSG00000123268#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IDA - PMID:1655749$#ENSG00000123268#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:2196176, PMID:8401579$#ENSG00000123268#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019 $#ENSP00000262053#ENSG00000123268#ENST00000262053#bZIP#pKID$#ENSP00000448921#ENSG00000123268#ENST00000552487#bZIP#pKID$#ENSP00000448592#ENSG00000123268#ENST00000552510#bZIP#pKID FALSE 163 ENSG00000115966 ATF2 bZIP Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR004827;IPR007087;IPR016378; 1386 activating transcription factor 2 [Source:HGNC Symbol;Acc:HGNC:784] 1T2K DBD and Full Yes None Structure has IRF3;ATF2;JUN a Yes TF Gene_DNA-Binding: sequence-specific_Transactivation_PMIDS:1658708;2529117;9139739;10909971 Yes 1a1, Direct HQ evidence Pratyush Das Jussi Taipale Yes $#ENSG00000115966#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000115966#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IC - GO_REF:0000036$#ENSG00000115966#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:8798441$#ENSG00000115966#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#IC - PMID:19861239$#ENSG00000115966#GO:0051090#regulation of sequence-specific DNA binding transcription factor activity#TAS - Reactome:R-HSA-450341$#ENSG00000115966#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IMP - PMID:10821277 $#ENSP00000264110#ENSG00000115966#ENST00000264110#bZIP#$#ENSP00000340576#ENSG00000115966#ENST00000345739#bZIP#$#ENSP00000376327#ENSG00000115966#ENST00000392544#bZIP#$#ENSP00000386282#ENSG00000115966#ENST00000409499#bZIP#$#ENSP00000386526#ENSG00000115966#ENST00000409833#bZIP#$#ENSP00000407911#ENSG00000115966#ENST00000426833#bZIP# FALSE 164 ENSG00000162772 ATF3 bZIP Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000837;IPR004827 467 activating transcription factor 3 [Source:HGNC Symbol;Acc:HGNC:785] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:11916968;12815047 Yes 1a1, Direct HQ evidence Jussi Taipale Laura Campitelli Yes $#ENSG00000162772#GO:0000982#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IBA - GO_REF:0000033$#ENSG00000162772#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000162772#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IC - GO_REF:0000036$#ENSG00000162772#GO:0003700#sequence-specific DNA binding transcription factor activity#IGI - PMID:24939851 $#ENSP00000336908#ENSG00000162772#ENST00000336937#bZIP#$#ENSP00000344352#ENSG00000162772#ENST00000341491#bZIP#$#ENSP00000355948#ENSG00000162772#ENST00000366981#bZIP#$#ENSP00000355950#ENSG00000162772#ENST00000366983#bZIP#$#ENSP00000355954#ENSG00000162772#ENST00000366987#bZIP#$#ENSP00000480606#ENSG00000162772#ENST00000613104#bZIP# FALSE 165 ENSG00000128272 ATF4 bZIP Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR004827; 468 activating transcription factor 4 [Source:HGNC Symbol;Acc:HGNC:786] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_Transactivation_PMIDS:15109498;16000305 Yes 1a1, Direct HQ evidence Matt Weirauch Jussi Taipale Yes $#ENSG00000128272#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IC - PMID:21113145 | IDA - PMID:11478948, PMID:128$#ENSG00000128272#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000128272#GO:0003700#sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024 | TAS - PMID:12689582 $#ENSP00000336790#ENSG00000128272#ENST00000337304#bZIP#$#ENSP00000379912#ENSG00000128272#ENST00000396680#bZIP#$#ENSP00000384587#ENSG00000128272#ENST00000404241#bZIP# FALSE 166 ENSG00000169136 ATF5 bZIP Yes Known motif Obligate heteromer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain Transfac motifs dont correspond to canonical bZIP binding sites. Annotated as obligate heteromer based on peptide array studies (PMID:12805554). IPR004827; 100616483 activating transcription factor 5 [Source:HGNC Symbol;Acc:HGNC:790] None DBD and Full Yes Obligate_Multimer pmid:12805554 has strong preference for forming heterodimers with CEBPG and other CEBP:s over homodimer based on Newman et al 2003 a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:15735663;16164412 Yes 2a1, Lower confidence direct evidence Laura Campitelli Sam Lambert Yes $#ENSG00000169136#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000169136#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IC - GO_REF:0000036$#ENSG00000169136#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:20654631 | ISS - GO_REF:0000024 $#ENSP00000396954#ENSG00000169136#ENST00000423777#bZIP#$#ENSP00000470633#ENSG00000169136#ENST00000595125#bZIP#$#ENSP00000470464#ENSG00000169136#ENST00000596658#bZIP#$#ENSP00000471162#ENSG00000169136#ENST00000600336#bZIP#$#ENSP00000470978#ENSG00000169136#ENST00000597227#bZIP# FALSE 167 ENSG00000118217 ATF6 bZIP Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR004827; 22926 activating transcription factor 6 [Source:HGNC Symbol;Acc:HGNC:791] None DBD and Full Yes None None a Yes TF Gene Candidate_DNA-Binding: sequence-specific; Transcription Factor Binding: tf co-factor binding_Co-activation; DNA Binding_PMIDS:9271374;14765107 Yes 1a1, Direct HQ evidence Sam Lambert Laura Campitelli Yes $#ENSG00000118217#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:11163209 $#ENSP00000356919#ENSG00000118217#ENST00000367942#bZIP# FALSE 168 ENSG00000213676 ATF6B bZIP Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR004827; 1388 activating transcription factor 6 beta [Source:HGNC Symbol;Acc:HGNC:2349] None DBD Yes None None a Yes No No 3a, decent circumstantial evidence for its role as Sam Lambert Pratyush Das Yes $#ENSG00000213676#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:11256944 $#ENSP00000364347#ENSG00000213676#ENST00000375201#bZIP#$#ENSP00000364349#ENSG00000213676#ENST00000375203#bZIP#$#ENSP00000393419#ENSG00000213676#ENST00000453203#bZIP# FALSE 169 ENSG00000170653 ATF7 bZIP Yes Known motif Monomer or homomultimer High-throughput in vitro None Some isoforms also contain a single C2H2 ZF. This is known to facilitate protein interactions (see Uniprot page), so ATF7 is only classified here as a bZIP protein IPR004827;IPR007087;IPR015880;IPR016378 11016 activating transcription factor 7 [Source:HGNC Symbol;Acc:HGNC:792] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:1694576;11278933;15735663;11278933;15735663 Yes 1a1, Direct HQ evidence Sam Lambert Matt Weirauch Yes $#ENSG00000170653#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002 $#ENSP00000399465#ENSG00000170653#ENST00000420353#bZIP#$#ENSP00000456858#ENSG00000170653#ENST00000548118#bZIP#$#ENSP00000465192#ENSG00000170653#ENST00000591397#bZIP#$#ENSP00000449938#ENSG00000170653#ENST00000548446#bZIP# FALSE 170 ENSG00000156273 BACH1 bZIP Yes Known motif Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain None IPR000210;IPR004826;IPR004827;IPR008917;IPR011333;IPR013069 100379661 BTB domain and CNC homolog 1 [Source:HGNC Symbol;Acc:HGNC:935] None DBD and Full Yes None pmid:12805554 has strong preference for forming heterodimers with MAFG and MAFK over homodimer based on Newman et al 2003 a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:10620011 Yes 1a1, Direct HQ evidence Laura Campitelli Yimeng Yin Yes $#ENSG00000156273#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:12511571 | IMP - PMID:21555518$#ENSG00000156273#GO:0001205#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involv#IEA - GO_REF:0000019$#ENSG00000156273#GO:0001206#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involv#IEA - GO_REF:0000019$#ENSG00000156273#GO:0003700#sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024 $#ENSP00000286800#ENSG00000156273#ENST00000286800#bZIP#BTB$#ENSP00000382805#ENSG00000156273#ENST00000399921#bZIP#BTB$#ENSP00000408605#ENSG00000156273#ENST00000447177#bZIP#BTB$#ENSP00000448663#ENSG00000156273#ENST00000547141#bZIP#$#ENSP00000447332#ENSG00000156273#ENST00000548219#bZIP#$#ENSP00000448982#ENSG00000156273#ENST00000548467#bZIP#$#ENSP00000449316#ENSG00000156273#ENST00000550131#bZIP#$#ENSP00000392202#ENSG00000156273#ENST00000435072#bZIP#BTB$#ENSP00000400576#ENSG00000156273#ENST00000451655#bZIP#BTB$#ENSP00000470673#ENSG00000156273#ENST00000468059#bZIP#$#ENSP00000449383#ENSG00000156273#ENST00000546469#bZIP# FALSE 171 ENSG00000112182 BACH2 bZIP Yes Known motif Monomer or homomultimer High-throughput in vitro None Based on Newman et al 2003 (PMID: 12805554), the protein has strong preference for forming heterodimers with MAFG and MAFK over homo-dimerisation. The Homer ChIP-seq motif appears to be a MAF-BACH2 heterodimer. IPR000210;IPR004826;IPR004827;IPR008917;IPR011333;IPR013069 60468 BTB domain and CNC homolog 2 [Source:HGNC Symbol;Acc:HGNC:14078] None DBD Yes None pmid:12805554 has strong preference for forming heterodimers with MAFG and MAFK over homodimer based on Newman et al 2003 a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:8887638;10949928 Yes 1a1, Direct HQ evidence Yimeng Yin Arttu Jolma Yes $#ENSG00000112182#GO:0001206#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involv#IEA - GO_REF:0000019$#ENSG00000112182#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000257749#ENSG00000112182#ENST00000257749#bZIP#BTB$#ENSP00000437473#ENSG00000112182#ENST00000537989#bZIP#BTB$#ENSP00000384145#ENSG00000112182#ENST00000406998#bZIP#BTB FALSE 172 ENSG00000156127 BATF bZIP Yes Known motif Monomer or homomultimer High-throughput in vitro None Prefers to heterodimerize, but it has an HT-SELEX (homodimer) motif. Its homodimerization Kd is 184nM and its best heterodimer is with CEBPG (<1nM) (PMID: 23661758). IPR000837;IPR004827 10538 basic leucine zipper ATF-like transcription factor [Source:HGNC Symbol;Acc:HGNC:958] None DBD and Full Yes None None a Yes TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI; Transactivation_PMIDS:10777209;11466704 Yes 1a1, Direct HQ evidence Jussi Taipale Laura Campitelli Yes $#ENSG00000156127#GO:0000982#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IBA - GO_REF:0000033$#ENSG00000156127#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000156127#GO:0003700#sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024 $#ENSP00000286639#ENSG00000156127#ENST00000286639#bZIP#$#ENSP00000450486#ENSG00000156127#ENST00000555504#bZIP# FALSE 173 ENSG00000168062 BATF2 bZIP Yes Likely to be sequence specific TF Obligate heteromer No motif None Part of AP-1 complex - there is no evidence it can bind on its own as a homodimer. IPR004827; 116071 basic leucine zipper ATF-like transcription factor 2 [Source:HGNC Symbol;Acc:HGNC:25163] None DBD and Full Yes Obligate_Multimer Heterodimerize with Jun and possible other bZIP proteins PMID:23787991 a Yes No Yes 3a, decent circumstantial evidence for its role as Matt Weirauch Jussi Taipale Yes $#ENSG00000168062#GO:0000982#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IBA - GO_REF:0000033 $#ENSP00000301887#ENSG00000168062#ENST00000301887#bZIP#$#ENSP00000398911#ENSG00000168062#ENST00000435842#bZIP#$#ENSP00000434915#ENSG00000168062#ENST00000527716#bZIP#HALZ$#ENSP00000435640#ENSG00000168062#ENST00000534177#bZIP# FALSE 174 ENSG00000123685 BATF3 bZIP Yes Known motif Monomer or homomultimer High-throughput in vitro None Transfac motif is dubious. IPR000837;IPR004827 55509 basic leucine zipper ATF-like transcription factor 3 [Source:HGNC Symbol;Acc:HGNC:28915] None DBD and Full Yes None None b Yes No Yes 1a1, Direct HQ evidence Arttu Jolma Jussi Taipale Yes $#ENSG00000123685#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:15467742$#ENSG00000123685#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:10878360 $#ENSP00000243440#ENSG00000123685#ENST00000243440#bZIP# FALSE 175 ENSG00000188848 BEND4 bZIP No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Lacks the basic region of the bZIP domain. IPR018379; 389206 BEN domain containing 4 [Source:HGNC Symbol;Acc:HGNC:23815] None not tested not tested None Not a proper bZIP, contains only a small leusine zipper region but lacks the DNA-interfacing basic part No Yes No No 5a, one of the source datasets predicts is as a TF Jussi Taipale Sam Lambert No None $#ENSP00000421169#ENSG00000188848#ENST00000502486#bZIP#BEN$#ENSP00000421160#ENSG00000188848#ENST00000504360#bZIP#$#ENSP00000478660#ENSG00000188848#ENST00000611697#bZIP#BEN FALSE 176 ENSG00000151468 CCDC3 bZIP No Unlikely to be sequence specific TF Not a DNA binding protein No motif None bZIP domain is truncated and lacks the DNA-contacting residues. None 83643 coiled-coil domain containing 3 [Source:HGNC Symbol;Acc:HGNC:23813] None not tested not tested None Not a proper bZIP, contains only a small leusine zipper region but lacks the DNA-interfacing basic part No Yes No No 5a, one of the source datasets predicts is as a TF Arttu Jolma Sam Lambert No None $#ENSP00000368102#ENSG00000151468#ENST00000378825#bZIP#DUF489, DUF812, DegS, KLRAQ, YscO$#ENSP00000368116#ENSG00000151468#ENST00000378839#bZIP# FALSE 177 ENSG00000150676 CCDC83 bZIP No Unlikely to be sequence specific TF Not a DNA binding protein No motif None bZIP domains are truncated, such that they are likely just coiled-coiled regions with no DNA-binding ability. None 220047 coiled-coil domain containing 83 [Source:HGNC Symbol;Acc:HGNC:28535] None not tested not tested None None No Yes No No 5a, one of the source datasets predicts is as a TF Laura Campitelli Sam Lambert No None $#ENSP00000344512#ENSG00000150676#ENST00000342404#bZIP#TSC22$#ENSP00000434373#ENSG00000150676#ENST00000526729#bZIP#$#ENSP00000280245#ENSG00000150676#ENST00000280245#bZIP#TSC22 FALSE 178 ENSG00000245848 CEBPA bZIP Yes Known motif Monomer or homomultimer 100 perc ID - in vitro None None IPR004827;IPR016468 1050 CCAAT/enhancer binding protein alpha [Source:HGNC Symbol;Acc:HGNC:1833] 1NWQ not tested Yes None Structure is a homodimer No Yes TF Gene_DNA-Binding: sequence-specific_Transactivation_PMIDS:2227417;8632009 Yes 1a1, Direct HQ evidence Yimeng Yin Pratyush Das Yes $#ENSG00000245848#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000245848#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IMP - PMID:16946298$#ENSG00000245848#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:11242107, PMID:12695546, PMID:15664994$#ENSG00000245848#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#NAS - PMID:7575576 $#ENSP00000427514#ENSG00000245848#ENST00000498907#bZIP# FALSE 179 ENSG00000172216 CEBPB bZIP Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR004827;IPR016468 1051 CCAAT/enhancer binding protein beta [Source:HGNC Symbol;Acc:HGNC:1834] 1GTW DBD Yes None Structure is a homodimer a Yes TF Gene_DNA-Binding: sequence-specific; Transcription Factor Binding: tf co-factor binding_Co-activation; DNA Binding; TF PPI; Transactivation_PMIDS:15308669;15713650 Yes 1a1, Direct HQ evidence Jussi Taipale Yimeng Yin Yes $#ENSG00000172216#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000172216#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:10821850$#ENSG00000172216#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024 $#ENSP00000305422#ENSG00000172216#ENST00000303004#bZIP# FALSE 180 ENSG00000221869 CEBPD bZIP Yes Known motif Monomer or homomultimer High-throughput in vitro None CEBPD binds as both a homodimer and as a heterdimer with other C/EBP TFs (PMID: 1884998; PMID: 12805554). IPR004827;IPR016468 1052 CCAAT/enhancer binding protein delta [Source:HGNC Symbol;Acc:HGNC:1835] None DBD Yes None None b Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:8572170;16192306 No 1a1, Direct HQ evidence Sam Lambert Arttu Jolma Yes $#ENSG00000221869#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019 $#ENSP00000386165#ENSG00000221869#ENST00000408965#bZIP# FALSE 181 ENSG00000092067 CEBPE bZIP Yes Known motif Monomer or homomultimer High-throughput in vitro None Also forms heterodimers. IPR004827;IPR016468 1053 CCAAT/enhancer binding protein epsilon [Source:HGNC Symbol;Acc:HGNC:1836] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific; Transcription Factor Binding: tf co-factor binding_Transactivation_PMIDS:9593684;10233885 Yes 1a1, Direct HQ evidence Jussi Taipale Yimeng Yin Yes $#ENSG00000092067#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:10233885 $#ENSP00000206513#ENSG00000092067#ENST00000206513#bZIP# FALSE 182 ENSG00000153879 CEBPG bZIP Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR004827; 1054 CCAAT/enhancer binding protein gamma [Source:HGNC Symbol;Acc:HGNC:1837] None DBD and Full Yes None None a Yes TF Gene Candidate_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:7501458;15833715 Yes 1a1, Direct HQ evidence Jussi Taipale Laura Campitelli Yes $#ENSG00000153879#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:15833715$#ENSG00000153879#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#ISS - PMID:7501458$#ENSG00000153879#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#TAS - PMID:7665092 $#ENSP00000284000#ENSG00000153879#ENST00000284000#bZIP#$#ENSP00000466022#ENSG00000153879#ENST00000585933#bZIP# FALSE 183 ENSG00000118260 CREB1 bZIP Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001630;IPR003102;IPR004827; 1385 cAMP responsive element binding protein 1 [Source:HGNC Symbol;Acc:HGNC:2345] 1DH3 DBD and Full Yes None Structure is a homodimer a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:14593102;15054091 Yes 1a1, Direct HQ evidence Pratyush Das Tim Hughes Yes $#ENSG00000118260#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IC - GO_REF:0000036$#ENSG00000118260#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:8798441$#ENSG00000118260#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#IDA - PMID:19861239 $#ENSP00000236995#ENSG00000118260#ENST00000353267#bZIP#pKID$#ENSP00000387699#ENSG00000118260#ENST00000432329#bZIP#pKID$#ENSP00000401803#ENSG00000118260#ENST00000455757#bZIP#$#ENSP00000391125#ENSG00000118260#ENST00000457101#bZIP#pKID FALSE 184 ENSG00000107175 CREB3 bZIP Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR004827; 10488 CAMP responsive element binding protein 3 None DBD and Full Yes None None a Yes No No 1a1, Direct HQ evidence Matt Weirauch Laura Campitelli Yes $#ENSG00000107175#GO:0000982#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:16940180$#ENSG00000107175#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IMP - PMID:16940180 $#ENSP00000342136#ENSG00000107175#ENST00000353704#bZIP# FALSE 185 ENSG00000157613 CREB3L1 bZIP Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001630;IPR004827 90993 cAMP responsive element binding protein 3 like 1 [Source:HGNC Symbol;Acc:HGNC:18856] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:15665855;16236796 Yes 1a1, Direct HQ evidence Pratyush Das Sam Lambert Yes $#ENSG00000157613#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#ISS - GO_REF:0000024 $#ENSP00000481956#ENSG00000157613#ENST00000621158#bZIP#$#ENSP00000436574#ENSG00000157613#ENST00000530518#bZIP#$#ENSP00000431677#ENSG00000157613#ENST00000534787#bZIP# FALSE 186 ENSG00000182158 CREB3L2 bZIP Yes Known motif Monomer or homomultimer 100 perc ID - in vitro None None IPR004827; 64764 cAMP responsive element binding protein 3 like 2 [Source:HGNC Symbol;Acc:HGNC:23720] None DBD and Full Yes None None a Yes No No 1a1, Direct HQ evidence Sam Lambert Arttu Jolma Yes $#ENSG00000182158#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019 $#ENSP00000329140#ENSG00000182158#ENST00000330387#bZIP#$#ENSP00000410314#ENSG00000182158#ENST00000452463#bZIP#$#ENSP00000403550#ENSG00000182158#ENST00000456390#bZIP#$#ENSP00000402889#ENSG00000182158#ENST00000420629#bZIP#$#ENSP00000388917#ENSG00000182158#ENST00000458726#bZIP# FALSE 187 ENSG00000060566 CREB3L3 bZIP Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Gel-shift and reporter experiments demonstrate that CREB3L3 is a TF (PMID: 11353085). IPR004827; 84699 cAMP responsive element binding protein 3 like 3 [Source:HGNC Symbol;Acc:HGNC:18855] None not tested Yes None None b Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:11353085 Yes 1a2, Orthologous HQ evidence Sam Lambert Tim Hughes Yes $#ENSG00000060566#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IDA - PMID:11353085 | IMP - PMID:11353085 $#ENSP00000078445#ENSG00000060566#ENST00000078445#bZIP#$#ENSP00000469355#ENSG00000060566#ENST00000595923#bZIP#$#ENSP00000470119#ENSG00000060566#ENST00000602147#bZIP#$#ENSP00000472399#ENSG00000060566#ENST00000602257#bZIP# FALSE 188 ENSG00000143578 CREB3L4 bZIP Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR004827;IPR008917 148327 cAMP responsive element binding protein 3 like 4 [Source:HGNC Symbol;Acc:HGNC:18854] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:11956138;15938716 No 1a1, Direct HQ evidence Laura Campitelli Pratyush Das Yes $#ENSG00000143578#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IEA - GO_REF:0000019 $#ENSP00000271889#ENSG00000143578#ENST00000271889#bZIP#$#ENSP00000357589#ENSG00000143578#ENST00000368600#bZIP#$#ENSP00000357592#ENSG00000143578#ENST00000368603#bZIP#$#ENSP00000357596#ENSG00000143578#ENST00000368607#bZIP#$#ENSP00000357590#ENSG00000143578#ENST00000368601#bZIP# FALSE 189 ENSG00000146592 CREB5 bZIP Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR004827;IPR007087;IPR016378; 9586 cAMP responsive element binding protein 5 [Source:HGNC Symbol;Acc:HGNC:16844] None DBD and Full Yes None None a Yes No Yes 1a1, Direct HQ evidence Matt Weirauch Laura Campitelli Yes $#ENSG00000146592#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:8378084 $#ENSP00000350359#ENSG00000146592#ENST00000357727#bZIP#$#ENSP00000379592#ENSG00000146592#ENST00000396298#bZIP#$#ENSP00000379593#ENSG00000146592#ENST00000396299#bZIP#$#ENSP00000379594#ENSG00000146592#ENST00000396300#bZIP#$#ENSP00000387197#ENSG00000146592#ENST00000409603#bZIP#$#ENSP00000394979#ENSG00000146592#ENST00000426500#bZIP# FALSE 190 ENSG00000111269 CREBL2 bZIP Yes Inferred motif Monomer or homomultimer High-throughput in vitro None None IPR004827; 1389 cAMP responsive element binding protein like 2 [Source:HGNC Symbol;Acc:HGNC:2350] None DBD and Full Yes None None a Yes No Yes 1a2, Orthologous HQ evidence Pratyush Das Matt Weirauch Yes $#ENSG00000111269#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002 $#ENSP00000228865#ENSG00000111269#ENST00000228865#bZIP# FALSE 191 ENSG00000164463 CREBRF bZIP No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Tested on HT-SELEX and did not yield a motif. Binds to CREB3 and represses the unfolded protein response (PMID: 18391022). IPR004827; 153222 CREB3 regulatory factor [Source:HGNC Symbol;Acc:HGNC:24050] None DBD and Full not tested None None c Yes No No 4a, two or more datasets predict it as a TF Laura Campitelli Arttu Jolma No $#ENSG00000164463#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002 $#ENSP00000296953#ENSG00000164463#ENST00000296953#bZIP#$#ENSP00000428290#ENSG00000164463#ENST00000520420#bZIP#$#ENSP00000431107#ENSG00000164463#ENST00000522692#bZIP#$#ENSP00000430801#ENSG00000164463#ENST00000523161#bZIP# FALSE 192 ENSG00000137504 CREBZF bZIP Yes Inferred motif Monomer or homomultimer High-throughput in vitro None None IPR004827; 58487 CREB/ATF bZIP transcription factor [Source:HGNC Symbol;Acc:HGNC:24905] None DBD and Full Yes None None a Yes No Yes 1a1, Direct HQ evidence Laura Campitelli Pratyush Das Yes $#ENSG00000137504#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002$#ENSG00000137504#GO:0051090#regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:15705566 $#ENSP00000435980#ENSG00000137504#ENST00000534224#bZIP#$#ENSP00000433459#ENSG00000137504#ENST00000527447#bZIP# FALSE 193 ENSG00000095794 CREM bZIP Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001630;IPR003102;IPR004827; 1390 cAMP responsive element modulator None DBD and Full Yes None None a Yes No No 1a1, Direct HQ evidence Arttu Jolma Tim Hughes Yes $#ENSG00000095794#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002 $#ENSP00000341875#ENSG00000095794#ENST00000342105#bZIP#pKID$#ENSP00000265372#ENSG00000095794#ENST00000345491#bZIP#pKID$#ENSP00000345384#ENSG00000095794#ENST00000348787#bZIP#pKID$#ENSP00000346804#ENSG00000095794#ENST00000354759#bZIP#pKID$#ENSP00000363858#ENSG00000095794#ENST00000374726#bZIP#pKID$#ENSP00000420681#ENSG00000095794#ENST00000473940#bZIP#$#ENSP00000417807#ENSG00000095794#ENST00000487763#bZIP#$#ENSP00000344365#ENSG00000095794#ENST00000344351#bZIP#$#ENSP00000349387#ENSG00000095794#ENST00000356917#bZIP#$#ENSP00000420437#ENSG00000095794#ENST00000460270#bZIP#$#ENSP00000418336#ENSG00000095794#ENST00000463314#bZIP#$#ENSP00000419018#ENSG00000095794#ENST00000474362#bZIP#$#ENSP00000417562#ENSG00000095794#ENST00000474931#bZIP#$#ENSP00000417460#ENSG00000095794#ENST00000488328#bZIP#$#ENSP00000419075#ENSG00000095794#ENST00000488741#bZIP#$#ENSP00000417327#ENSG00000095794#ENST00000490511#bZIP#$#ENSP00000403938#ENSG00000095794#ENST00000427847#bZIP#pKID$#ENSP00000419810#ENSG00000095794#ENST00000468236#bZIP#$#ENSP00000473519#ENSG00000095794#ENST00000469949#bZIP#$#ENSP00000419924#ENSG00000095794#ENST00000489321#bZIP#pKID$#ENSP00000417399#ENSG00000095794#ENST00000494479#bZIP# FALSE 194 ENSG00000105516 DBP bZIP Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR004827; 1628 D-box binding PAR bZIP transcription factor [Source:HGNC Symbol;Acc:HGNC:2697] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:2331750 Yes 1a1, Direct HQ evidence Jussi Taipale Arttu Jolma Yes $#ENSG00000105516#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:20093779 $#ENSP00000222122#ENSG00000105516#ENST00000222122#bZIP#$#ENSP00000469291#ENSG00000105516#ENST00000601104#bZIP#$#ENSP00000471220#ENSG00000105516#ENST00000593500#bZIP#$#ENSP00000469426#ENSG00000105516#ENST00000599385#bZIP# FALSE 195 ENSG00000175197 DDIT3 bZIP Yes Known motif Obligate heteromer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain Has strong preference for forming heterodimers with BATF; DBP; HLF; CEBP[ABCD] over homodimerization (PMID: 12805554). IPR004827;IPR016670 1649 DNA damage inducible transcript 3 [Source:HGNC Symbol;Acc:HGNC:2726] None DBD and Full Yes Obligate_Multimer pmid:12805554 has strong preference for forming heterodimers with BATF, DBP, HLF, CEBP[ABCD] over homodimer based on Newman et al 2003 a Yes TF Gene_DNA-Binding: sequence-specific; Transcription Factor Binding: tf co-factor binding_Co-activation_PMIDS:8657121 Yes 2a1, Lower confidence direct evidence Pratyush Das Arttu Jolma Yes $#ENSG00000175197#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:22065586$#ENSG00000175197#GO:0003700#sequence-specific DNA binding transcription factor activity#IC - PMID:15322075 | IGI - PMID:24939851$#ENSG00000175197#GO:0032792#negative regulation of CREB transcription factor activity#IDA - PMID:8622660 | IGI - PMID:11478948$#ENSG00000175197#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:16434966 $#ENSP00000340671#ENSG00000175197#ENST00000346473#bZIP#$#ENSP00000448665#ENSG00000175197#ENST00000551116#bZIP#$#ENSP00000447803#ENSG00000175197#ENST00000552740#bZIP#$#ENSP00000447188#ENSG00000175197#ENST00000547303#bZIP#$#ENSP00000447503#ENSG00000175197#ENST00000547526#bZIP# FALSE 196 ENSG00000170345 FOS bZIP Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000837;IPR004827 2353 Fos proto-oncogene, AP-1 transcription factor subunit [Source:HGNC Symbol;Acc:HGNC:3796] 1A02 DBD and Full Yes None Structure has NFATC2, FOS and JUN bound to a site that has good match to NFATC but a bad one to a CRE-type bZIP site proteins are doing a massive protein-protein interaction interface;Prefers heterodimers with JUN, JUND and JUNB over homodimer, PMID: a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:8798512;11925568;15073183;2243767 Yes 1a1, Direct HQ evidence Matt Weirauch Laura Campitelli Yes $#ENSG00000170345#GO:0000982#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IBA - GO_REF:0000033$#ENSG00000170345#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000170345#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:9732876$#ENSG00000170345#GO:0051090#regulation of sequence-specific DNA binding transcription factor activity#TAS - Reactome:R-HSA-450341 $#ENSP00000306245#ENSG00000170345#ENST00000303562#bZIP#$#ENSP00000442268#ENSG00000170345#ENST00000535987#bZIP#$#ENSP00000450519#ENSG00000170345#ENST00000554617#bZIP#$#ENSP00000452386#ENSG00000170345#ENST00000555242#bZIP#$#ENSP00000450886#ENSG00000170345#ENST00000555347#bZIP#$#ENSP00000452440#ENSG00000170345#ENST00000555672#bZIP#DUF3450, IFT20$#ENSP00000452590#ENSG00000170345#ENST00000555686#bZIP# FALSE 197 ENSG00000125740 FOSB bZIP Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000837;IPR004827 2354 FosB proto-oncogene, AP-1 transcription factor subunit [Source:HGNC Symbol;Acc:HGNC:3797] None DBD and Full Yes None Prefers heterodimers with JUN, JUND and JUNB over homodimer, PMID:12805554 a Yes TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:2498083;14515349;16699069 Yes 1a1, Direct HQ evidence Laura Campitelli Sam Lambert Yes $#ENSG00000125740#GO:0000982#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IBA - GO_REF:0000033$#ENSG00000125740#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019 $#ENSP00000245919#ENSG00000125740#ENST00000353609#bZIP#$#ENSP00000407207#ENSG00000125740#ENST00000417353#bZIP#$#ENSP00000414177#ENSG00000125740#ENST00000443841#bZIP#DUF3450$#ENSP00000467497#ENSG00000125740#ENST00000585836#bZIP#$#ENSP00000468207#ENSG00000125740#ENST00000586615#bZIP#$#ENSP00000465068#ENSG00000125740#ENST00000590335#bZIP#$#ENSP00000466530#ENSG00000125740#ENST00000591858#bZIP#$#ENSP00000485018#ENSG00000125740#ENST00000615753#bZIP#$#ENSP00000468482#ENSG00000125740#ENST00000592811#bZIP# FALSE 198 ENSG00000175592 FOSL1 bZIP Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000837;IPR004827 8061 FOS like 1, AP-1 transcription factor subunit [Source:HGNC Symbol;Acc:HGNC:13718] None DBD and Full Yes None Prefers heterodimers with JUN, JUND and JUNB over homodimer, PMID:12805554 a Yes TF Gene_Transcription Factor Binding: tf co-factor binding; DNA-Binding: sequence-specific_DNA Binding_PMIDS:7504176;7791782;15608675 Yes 1a1, Direct HQ evidence Laura Campitelli Pratyush Das Yes $#ENSG00000175592#GO:0000982#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IBA - GO_REF:0000033$#ENSG00000175592#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000175592#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:10918580$#ENSG00000175592#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019 $#ENSP00000310170#ENSG00000175592#ENST00000312562#bZIP#$#ENSP00000393302#ENSG00000175592#ENST00000448083#bZIP#DUF3450$#ENSP00000436276#ENSG00000175592#ENST00000531493#bZIP#SPAM$#ENSP00000431594#ENSG00000175592#ENST00000532401#bZIP#$#ENSP00000434350#ENSG00000175592#ENST00000534222#bZIP# FALSE 199 ENSG00000075426 FOSL2 bZIP Yes Known motif Monomer or homomultimer High-throughput in vitro None Also forms heterodimers. IPR000837;IPR004827 2355 FOS like 2, AP-1 transcription factor subunit [Source:HGNC Symbol;Acc:HGNC:3798] None DBD and Full Yes None pmid:12805554 has strong preference for forming heterodimers with JUN, JUNB, JUND, CREB5 and ATF7 over homodimer based on Newman et al 2003 a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:13679379;15558021 Yes 1a1, Direct HQ evidence Sam Lambert Pratyush Das No $#ENSG00000075426#GO:0000982#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IBA - GO_REF:0000033$#ENSG00000075426#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:8954781 $#ENSP00000264716#ENSG00000075426#ENST00000264716#bZIP#$#ENSP00000368939#ENSG00000075426#ENST00000379619#bZIP#$#ENSP00000396497#ENSG00000075426#ENST00000436647#bZIP# FALSE 200 ENSG00000144366 GULP1 bZIP No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Based on the alignments, the protein is only weakly related to the other bZIP proteins and lacks the basic region required for DNA binding IPR006020; 51454 GULP, engulfment adaptor PTB domain containing 1 [Source:HGNC Symbol;Acc:HGNC:18649] None not tested not tested None Not a proper bZIP, contains only a small leusine zipper region but lacks the DNA-interfacing basic part No Yes No No 5a, one of the source datasets predicts is as a TF Arttu Jolma Sam Lambert No None $#ENSP00000352047#ENSG00000144366#ENST00000359135#bZIP#Ax_dynein_light, DivIC, PID, PID_2, PTB, Pox_A_typ$#ENSP00000386732#ENSG00000144366#ENST00000409830#bZIP#Ax_dynein_light, DivIC, PID, PID_2, PTB, Pox_A_typ$#ENSP00000387013#ENSG00000144366#ENST00000410051#bZIP#PID, PID_2, PTB$#ENSP00000407131#ENSG00000144366#ENST00000451191#bZIP#$#ENSP00000386289#ENSG00000144366#ENST00000409580#bZIP#Ax_dynein_light, DivIC, PID, PID_2, PTB, Pox_A_typ$#ENSP00000386867#ENSG00000144366#ENST00000409609#bZIP#Ax_dynein_light, DivIC, PID, PID_2, PTB, Pox_A_typ$#ENSP00000386402#ENSG00000144366#ENST00000409637#bZIP#PID, PID_2, PTB$#ENSP00000387171#ENSG00000144366#ENST00000409805#bZIP#Ax_dynein_light, DivIC, IncA, Pox_A_type_inc, bZIP$#ENSP00000387144#ENSG00000144366#ENST00000409843#bZIP#Ax_dynein_light, DivIC, PID, PID_2, PTB, bZIP_2$#ENSP00000391712#ENSG00000144366#ENST00000433052#bZIP#$#ENSP00000386809#ENSG00000144366#ENST00000409927#bZIP#PID FALSE 201 ENSG00000108924 HLF bZIP Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR004827; 3131 HLF, PAR bZIP transcription factor [Source:HGNC Symbol;Acc:HGNC:4977] None DBD and Full Yes None None b Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:8065331 Yes 1a1, Direct HQ evidence Sam Lambert Tim Hughes Yes $#ENSG00000108924#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IBA - GO_REF:0000033 $#ENSP00000226067#ENSG00000108924#ENST00000226067#bZIP#$#ENSP00000402496#ENSG00000108924#ENST00000430986#bZIP#$#ENSP00000460572#ENSG00000108924#ENST00000575345#bZIP#$#ENSP00000461455#ENSG00000108924#ENST00000572002#bZIP# FALSE 202 ENSG00000095066 HOOK2 bZIP No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Based on the alignments, the protein is only weakly related to the other bZIP proteins and lacks the basic region required for DNA binding IPR008636 29911 hook microtubule-tethering protein 2 [Source:HGNC Symbol;Acc:HGNC:19885] None not tested not tested None None No Yes No No 5a, one of the source datasets predicts is as a TF Laura Campitelli Matt Weirauch No None $#ENSP00000264827#ENSG00000095066#ENST00000264827#bZIP#HALZ, HOOK$#ENSP00000380785#ENSG00000095066#ENST00000397668#bZIP#HALZ, HOOK$#ENSP00000465042#ENSG00000095066#ENST00000587178#bZIP#HOOK$#ENSP00000466616#ENSG00000095066#ENST00000590839#bZIP#HOOK FALSE 203 ENSG00000140575 IQGAP1 bZIP No Unlikely to be sequence specific TF Not a DNA binding protein No motif None bZIP domain in the protein is just a fragment. IPR000048;IPR000593;IPR001202;IPR001715;IPR001936;IPR008936;IPR023152;IPR027417 8826 IQ motif containing GTPase activating protein 1 [Source:HGNC Symbol;Acc:HGNC:6110] None not tested not tested None None No Yes No No 5a, one of the source datasets predicts is as a TF Arttu Jolma Sam Lambert No None $#ENSP00000268182#ENSG00000140575#ENST00000268182#bZIP#CH, IQ, RasGAP, RasGAP_C, WW$#ENSP00000480393#ENSG00000140575#ENST00000560373#bZIP#IQ, WW$#ENSP00000484647#ENSG00000140575#ENST00000559809#bZIP# FALSE 204 ENSG00000140044 JDP2 bZIP Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000837;IPR004827 122953 Jun dimerization protein 2 [Source:HGNC Symbol;Acc:HGNC:17546] None DBD and Full Yes None None b Yes TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI; Transactivation_PMIDS:12052888 Yes 1a1, Direct HQ evidence Pratyush Das Arttu Jolma Yes $#ENSG00000140044#GO:0000982#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IBA - GO_REF:0000033$#ENSG00000140044#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019 $#ENSP00000267569#ENSG00000140044#ENST00000267569#bZIP#$#ENSP00000399587#ENSG00000140044#ENST00000435893#bZIP#$#ENSP00000415558#ENSG00000140044#ENST00000419727#bZIP#$#ENSP00000409787#ENSG00000140044#ENST00000437176#bZIP#$#ENSP00000452769#ENSG00000140044#ENST00000559060#bZIP# FALSE 205 ENSG00000177606 JUN bZIP Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR002112;IPR004827;IPR005643;IPR008917 3725 Jun proto-oncogene, AP-1 transcription factor subunit [Source:HGNC Symbol;Acc:HGNC:6204] 1JNM DBD and Full Yes None The structure is a homodimer; Prefers heterodimers with FOS, FOSB, FOSL1 and FOSL2 over homodimer, PMID:12805554 a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:12215258;15494506 Yes 1a1, Direct HQ evidence Sam Lambert Yimeng Yin Yes $#ENSG00000177606#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IC - PMID:21113145$#ENSG00000177606#GO:0000982#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IMP - PMID:19962668$#ENSG00000177606#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000177606#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:9732876$#ENSG00000177606#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#IC - PMID:19861239 | IDA - PMID:2833704$#ENSG00000177606#GO:0051090#regulation of sequence-specific DNA binding transcription factor activity#TAS - Reactome:R-HSA-450341 $#ENSP00000360266#ENSG00000177606#ENST00000371222#bZIP#Jun FALSE 206 ENSG00000171223 JUNB bZIP Yes Known motif Monomer or homomultimer High-throughput in vitro None Prefers forming heterodimers with FOS; FOSB; FOSL1 and FOSL2 over homodimers (PMID:12805554); but, clearly can bind DNA specifically in vitro. IPR002112;IPR004827;IPR005643;IPR008917 3726 JunB proto-oncogene, AP-1 transcription factor subunit [Source:HGNC Symbol;Acc:HGNC:6205] None DBD and Full Yes None Prefers heterodimers with FOS, FOSB, FOSL1 and FOSL2 over homodimer, PMID:12805554 a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:12121977 Yes 1a1, Direct HQ evidence Arttu Jolma Sam Lambert Yes $#ENSG00000171223#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000171223#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019 $#ENSP00000303315#ENSG00000171223#ENST00000302754#bZIP#Jun FALSE 207 ENSG00000130522 JUND bZIP Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR002112;IPR004827;IPR005643;IPR008917 3727 JunD proto-oncogene, AP-1 transcription factor subunit [Source:HGNC Symbol;Acc:HGNC:6206] None DBD Yes None Prefers heterodimers with FOS, FOSB, FOSL1 and FOSL2 over homodimer, PMID:12805554 a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:2504580 Yes 1a1, Direct HQ evidence Tim Hughes Laura Campitelli Yes $#ENSG00000130522#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000475153#ENSG00000130522#ENST00000600972#bZIP#Jun$#ENSP00000252818#ENSG00000130522#ENST00000252818#bZIP#Jun FALSE 208 ENSG00000163808 KIF15 bZIP No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Has a bZIP like fragment that lacks the basic region required for DNA binding and a STE-domain that is classified as a potential DBD in CIS-BP. It is a kinesin operating in the microtubule system (PMID: 24419385) IPR001752;IPR024658;IPR027417; 56992 kinesin family member 15 [Source:HGNC Symbol;Acc:HGNC:17273] None not tested not tested None Not a proper bZIP, contains only a small leusine zipper region but lacks the DNA-interfacing basic part No Yes No No 5a, one of the source datasets predicts is as a TF Arttu Jolma Matt Weirauch No None $#ENSP00000324020#ENSG00000163808#ENST00000326047#bZIP#HMMR_C, Kinesin, Microtub_bd$#ENSP00000389982#ENSG00000163808#ENST00000425755#bZIP#Bcr-Abl_Oligo, DMPK_coil, HMMR_C, Laminin_II$#ENSP00000425499#ENSG00000163808#ENST00000481166#bZIP#Bcr-Abl_Oligo, DMPK_coil, Kinesin, Laminin_II FALSE 209 ENSG00000171401 KRT13 bZIP No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Based on the alignments, the protein is only weakly related to the other bZIP proteins and lacks the basic region required for DNA binding IPR001664;IPR002957;IPR018039 3860 keratin 13 [Source:HGNC Symbol;Acc:HGNC:6415] None not tested not tested None None No Yes No No 5a, one of the source datasets predicts is as a TF Sam Lambert Laura Campitelli No None $#ENSP00000246635#ENSG00000171401#ENST00000246635#bZIP#Filament, TPR_MLP1_2$#ENSP00000336604#ENSG00000171401#ENST00000336861#bZIP#Filament, TPR_MLP1_2$#ENSP00000468221#ENSG00000171401#ENST00000587544#bZIP#Filament, TPR_MLP1_2 FALSE 210 ENSG00000178573 MAF bZIP Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR004826;IPR004827;IPR008917;IPR013592 4094 MAF bZIP transcription factor [Source:HGNC Symbol;Acc:HGNC:6776] None DBD and Full Yes None None a Yes No Yes 1a1, Direct HQ evidence Laura Campitelli Arttu Jolma Yes $#ENSG00000178573#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IBA - GO_REF:0000033 $#ENSP00000327048#ENSG00000178573#ENST00000326043#bZIP#Maf_N$#ENSP00000455097#ENSG00000178573#ENST00000569649#bZIP#Maf_N$#ENSP00000377019#ENSG00000178573#ENST00000393350#bZIP#Maf_N FALSE 211 ENSG00000182759 MAFA bZIP Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR004826;IPR004827;IPR008917;IPR013592 389692 MAF bZIP transcription factor A [Source:HGNC Symbol;Acc:HGNC:23145] 4EOT DBD Yes None Structure is a homodimer a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:15665000 Yes 1a1, Direct HQ evidence Pratyush Das Sam Lambert Yes $#ENSG00000182759#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000182759#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IBA - GO_REF:0000033$#ENSG00000182759#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:12368292, PMID:17941991 $#ENSP00000328364#ENSG00000182759#ENST00000333480#bZIP#Maf_N FALSE 212 ENSG00000204103 MAFB bZIP Yes Known motif Monomer or homomultimer 100 perc ID - in vitro None PDB:2WTY is a homodimer crystallised with TAATTGCTGACTCAGCAAAT sequence IPR004826;IPR004827;IPR008917;IPR013592 9935 MAF bZIP transcription factor B [Source:HGNC Symbol;Acc:HGNC:6408] 2WTY DBD and Full Yes None Structure is a homodimer a Yes TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:17158225;9571165 Yes 1a1, Direct HQ evidence Arttu Jolma Pratyush Das Yes $#ENSG00000204103#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000204103#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IBA - GO_REF:0000033 $#ENSP00000362410#ENSG00000204103#ENST00000373313#bZIP#Maf_N FALSE 213 ENSG00000185022 MAFF bZIP Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR004826;IPR004827;IPR008917; 23764 MAF bZIP transcription factor F [Source:HGNC Symbol;Acc:HGNC:6780] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; TF PPI; Transactivation_PMIDS:8107826;12490281 Yes 1a1, Direct HQ evidence Sam Lambert Pratyush Das Yes $#ENSG00000185022#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IBA - GO_REF:0000033 $#ENSP00000345393#ENSG00000185022#ENST00000338483#bZIP#$#ENSP00000384094#ENSG00000185022#ENST00000407965#bZIP#$#ENSP00000391589#ENSG00000185022#ENST00000441709#bZIP#$#ENSP00000441482#ENSG00000185022#ENST00000538999#bZIP# FALSE 214 ENSG00000197063 MAFG bZIP Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR004826;IPR004827;IPR008917; 4097 MAF bZIP transcription factor G [Source:HGNC Symbol;Acc:HGNC:6781] 3A5T DBD and Full Yes None Structure is a homodimer a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Other_PMIDS:9421508;15574414 Yes 1a1, Direct HQ evidence Pratyush Das Yimeng Yin Yes $#ENSG00000197063#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IBA - GO_REF:0000033$#ENSG00000197063#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:9286713 $#ENSP00000350369#ENSG00000197063#ENST00000357736#bZIP#$#ENSP00000376173#ENSG00000197063#ENST00000392366#bZIP#$#ENSP00000459634#ENSG00000197063#ENST00000574686#bZIP# FALSE 215 ENSG00000198517 MAFK bZIP Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR004826;IPR004827;IPR008917; 7975 MAF bZIP transcription factor K [Source:HGNC Symbol;Acc:HGNC:6782] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Other; Transactivation_PMIDS:11013233;14960151 Yes 1a1, Direct HQ evidence Pratyush Das Arttu Jolma Yes $#ENSG00000198517#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IBA - GO_REF:0000033$#ENSG00000198517#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:9150357 $#ENSP00000344903#ENSG00000198517#ENST00000343242#bZIP#$#ENSP00000385437#ENSG00000198517#ENST00000406174#bZIP# FALSE 216 ENSG00000159256 MORC3 bZIP No ssDNA/RNA binding Not a DNA binding protein No motif None Lacks a canonical bZIP DBD but: regulates TP53 activity (PMID: 17332504]), binds RNA in vitro (PMID: 11927593), and may be required for influenza A transcription during viral infection (PMID: 26202233). IPR003594;IPR011124 23515 MORC family CW-type zinc finger 3 [Source:HGNC Symbol;Acc:HGNC:23572] None not tested not tested None None No Yes No No 5a, one of the source datasets predicts is as a TF Laura Campitelli Sam Lambert No None $#ENSP00000383333#ENSG00000159256#ENST00000400485#bZIP#DUF2353, HATPase_c, HATPase_c_3, HOOK, zf-CW FALSE 217 ENSG00000080986 NDC80 bZIP No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Based on the alignments, the protein is only weakly related to the other bZIP proteins and lacks the basic region required for DNA binding IPR005550 10403 NDC80, kinetochore complex component [Source:HGNC Symbol;Acc:HGNC:16909] None not tested not tested None None No Yes No No 5a, one of the source datasets predicts is as a TF Yimeng Yin Pratyush Das No None $#ENSP00000261597#ENSG00000080986#ENST00000261597#bZIP#ADIP, DUF1664, Ndc80_HEC$#ENSP00000458236#ENSG00000080986#ENST00000574096#bZIP#$#ENSP00000476919#ENSG00000080986#ENST00000576274#bZIP#Ndc80_HEC$#ENSP00000461227#ENSG00000080986#ENST00000575515#bZIP# FALSE 218 ENSG00000123405 NFE2 bZIP Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR004826;IPR004827;IPR008917; 4778 nuclear factor, erythroid 2 [Source:HGNC Symbol;Acc:HGNC:7780] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:8469283 Yes 1a1, Direct HQ evidence Laura Campitelli Yimeng Yin Yes $#ENSG00000123405#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002 $#ENSP00000312436#ENSG00000123405#ENST00000312156#bZIP#$#ENSP00000397185#ENSG00000123405#ENST00000435572#bZIP#$#ENSP00000439120#ENSG00000123405#ENST00000540264#bZIP#$#ENSP00000447558#ENSG00000123405#ENST00000553070#bZIP# FALSE 219 ENSG00000082641 NFE2L1 bZIP Yes Known motif Obligate heteromer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain Tested on HT-SELEX and PBM. Neither yielded a motif. Likely an obligate heteromer (PMID: 23661758). IPR004826;IPR004827;IPR008917; 4779 nuclear factor, erythroid 2 like 1 [Source:HGNC Symbol;Acc:HGNC:7781] None DBD and Full Yes Obligate_Multimer pmid:12805554 has strong preference for forming heterodimers with MAFG and MAFK over homodimer based on Newman et al 2003 a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:8036168 Yes 2a1, Lower confidence direct evidence Tim Hughes Matt Weirauch Yes $#ENSG00000082641#GO:0001205#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involv#IEA - GO_REF:0000019$#ENSG00000082641#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:8248256 $#ENSP00000350072#ENSG00000082641#ENST00000357480#bZIP#$#ENSP00000354855#ENSG00000082641#ENST00000362042#bZIP#$#ENSP00000461960#ENSG00000082641#ENST00000585291#bZIP#$#ENSP00000445811#ENSG00000082641#ENST00000536222#bZIP#$#ENSP00000464446#ENSG00000082641#ENST00000582155#bZIP#$#ENSP00000462003#ENSG00000082641#ENST00000579889#bZIP#$#ENSP00000461971#ENSG00000082641#ENST00000581319#bZIP# FALSE 220 ENSG00000116044 NFE2L2 bZIP Yes Known motif Obligate heteromer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain Has been tested by both PBM and HT-SELEX. Neither yielded a motif. Likely obligate heteromer. IPR004826;IPR004827;IPR008917; 4780 nuclear factor, erythroid 2 like 2 [Source:HGNC Symbol;Acc:HGNC:7782] None DBD and Full Yes Obligate_Multimer pmid:12805554 has strong preference for forming heterodimers with MAFG and MAFK over homodimer based on Newman et al 2003 a Yes TF Gene_DNA-Binding: sequence-specific__PMIDS:0; Yes 2a1, Lower confidence direct evidence Pratyush Das Jussi Taipale Yes $#ENSG00000116044#GO:0001205#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involv#IEA - GO_REF:0000019$#ENSG00000116044#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:17015834 $#ENSP00000380252#ENSG00000116044#ENST00000397062#bZIP#$#ENSP00000380253#ENSG00000116044#ENST00000397063#bZIP#$#ENSP00000412191#ENSG00000116044#ENST00000421929#bZIP#$#ENSP00000410015#ENSG00000116044#ENST00000423513#bZIP#$#ENSP00000411575#ENSG00000116044#ENST00000446151#bZIP#$#ENSP00000400073#ENSG00000116044#ENST00000448782#bZIP#$#ENSP00000467401#ENSG00000116044#ENST00000464747#bZIP#$#ENSP00000391291#ENSG00000116044#ENST00000430047#bZIP#$#ENSP00000416308#ENSG00000116044#ENST00000458603#bZIP# FALSE 221 ENSG00000050344 NFE2L3 bZIP Yes Known motif Obligate heteromer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain Tested on HT-SELEX and PBM. Neither yielded a motif. Likely an obligate heteromer (PMID: 23661758). Strong preference for forming heterodimers with MAFG and MAFK over homodimers (PMID: 12805554). IPR004826;IPR004827;IPR008917; 9603 nuclear factor, erythroid 2 like 3 [Source:HGNC Symbol;Acc:HGNC:7783] None DBD and Full Yes Obligate_Multimer pmid:12805554 has strong preference for forming heterodimers with MAFG and MAFK over homodimer based on Newman et al 2003 a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:10037736;15385560 Yes 2a1, Lower confidence direct evidence Arttu Jolma Matt Weirauch Yes $#ENSG00000050344#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000050344#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:10037736 $#ENSP00000056233#ENSG00000050344#ENST00000056233#bZIP#$#ENSP00000475463#ENSG00000050344#ENST00000607375#bZIP# FALSE 222 ENSG00000165030 NFIL3 bZIP Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR004827;IPR010533;IPR016743; 4783 nuclear factor, interleukin 3 regulated [Source:HGNC Symbol;Acc:HGNC:7787] None DBD and Full Yes None None b Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:7565758;10074173 Yes 1a1, Direct HQ evidence Laura Campitelli Arttu Jolma Yes $#ENSG00000165030#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:20093779$#ENSG00000165030#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:7565758 $#ENSP00000297689#ENSG00000165030#ENST00000297689#bZIP#Vert_IL3-reg_TF FALSE 223 ENSG00000148572 NRBF2 bZIP No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Based on the alignments, the protein is only weakly related to the other bZIP proteins and lacks the basic region required for DNA binding IPR015056; 29982 nuclear receptor binding factor 2 [Source:HGNC Symbol;Acc:HGNC:19692] None not tested not tested None Not a proper bZIP, contains only a small leusine zipper region but lacks the DNA-interfacing basic part No Yes No No 5a, one of the source datasets predicts is as a TF Jussi Taipale Matt Weirauch No None $#ENSP00000277746#ENSG00000148572#ENST00000277746#bZIP#MIT, NRBF2_MIT$#ENSP00000397502#ENSG00000148572#ENST00000435510#bZIP#NRBF2_MIT FALSE 224 ENSG00000129535 NRL bZIP Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR004826;IPR004827;IPR008917;IPR013592 4901 neural retina leucine zipper [Source:HGNC Symbol;Acc:HGNC:8002] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:8552602;8939891;12566383;15001570;17335001;8552602;8552602;10887186;15001570 Yes 1a1, Direct HQ evidence Pratyush Das Arttu Jolma Yes $#ENSG00000129535#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:8552602 $#ENSP00000380191#ENSG00000129535#ENST00000396995#bZIP#$#ENSP00000380193#ENSG00000129535#ENST00000396997#bZIP#Maf_N$#ENSP00000380197#ENSG00000129535#ENST00000397002#bZIP#Maf_N$#ENSP00000452966#ENSG00000129535#ENST00000560550#bZIP#$#ENSP00000454062#ENSG00000129535#ENST00000561028#bZIP#Maf_N FALSE 225 ENSG00000162869 PPP1R21 bZIP No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Protein lacks the basic region these proteins use to contact the DNA IPR019343;IPR019348 129285 protein phosphatase 1 regulatory subunit 21 [Source:HGNC Symbol;Acc:HGNC:30595] None not tested not tested None None No Yes No No 5a, one of the source datasets predicts is as a TF Laura Campitelli Yimeng Yin No None $#ENSP00000281394#ENSG00000162869#ENST00000281394#bZIP#KLRAQ, TTKRSYEDQ$#ENSP00000294952#ENSG00000162869#ENST00000294952#bZIP#KLRAQ, TTKRSYEDQ$#ENSP00000415696#ENSG00000162869#ENST00000449090#bZIP#KLRAQ, TTKRSYEDQ$#ENSP00000410955#ENSG00000162869#ENST00000421486#bZIP# FALSE 226 ENSG00000131242 RAB11FIP4 bZIP No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Likely false-positive - appears to function primarily in the cytoplasm (PMID: 12470645). IPR002048;IPR019018 100616248 RAB11 family interacting protein 4 [Source:HGNC Symbol;Acc:HGNC:30267] None not tested Yes None Not a proper bZIP, contains only a small leusine zipper region but lacks the DNA-interfacing basic part No Yes No No 5a, one of the source datasets predicts is as a TF Laura Campitelli Yimeng Yin No None $#ENSP00000482620#ENSG00000131242#ENST00000621161#bZIP#EF-hand_8, RBD-FIP, Shugoshin_N$#ENSP00000378227#ENSG00000131242#ENST00000394744#bZIP#RBD-FIP, Shugoshin_N$#ENSP00000463206#ENSG00000131242#ENST00000582009#bZIP#EF-hand_8$#ENSP00000465929#ENSG00000131242#ENST00000583755#bZIP# FALSE 227 ENSG00000152193 RNF219 bZIP No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Not a proper bZIP; contains only a small leucine zipper region but lacks the DNA-interfacing basic part. IPR001841; 79596 ring finger protein 219 [Source:HGNC Symbol;Acc:HGNC:20308] None not tested Yes None Not a proper bZIP, contains only a small leusine zipper region but lacks the DNA-interfacing basic part No Yes No No 5a, one of the source datasets predicts is as a TF Yimeng Yin Arttu Jolma No None $#ENSP00000282003#ENSG00000152193#ENST00000282003#bZIP#zf-C3HC4, zf-C3HC4_2, zf-C3HC4_3, zf-P11, zf-RING_ FALSE 228 ENSG00000153130 SCOC bZIP No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Not a proper bZIP; contains only a small leucine zipper region but lacks the DNA-interfacing basic part. IPR019357; 60592 short coiled-coil protein [Source:HGNC Symbol;Acc:HGNC:20335] None not tested not tested None Not a proper bZIP, contains only a small leusine zipper region but lacks the DNA-interfacing basic part No Yes No No 5a, one of the source datasets predicts is as a TF Arttu Jolma Pratyush Das No None $#ENSP00000377751#ENSG00000153130#ENST00000394201#bZIP#$#ENSP00000426649#ENSG00000153130#ENST00000506597#bZIP#$#ENSP00000477352#ENSG00000153130#ENST00000608372#bZIP#DUF2205, HALZ, IncA$#ENSP00000477812#ENSG00000153130#ENST00000614192#bZIP#DUF2205, HALZ, IncA$#ENSP00000377753#ENSG00000153130#ENST00000394203#bZIP#$#ENSP00000377755#ENSG00000153130#ENST00000394205#bZIP#$#ENSP00000421355#ENSG00000153130#ENST00000502535#bZIP#$#ENSP00000424605#ENSG00000153130#ENST00000512749#bZIP# FALSE 229 ENSG00000167074 TEF bZIP Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR004827; 7008 TEF, PAR bZIP transcription factor [Source:HGNC Symbol;Acc:HGNC:11722] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:8396764;8440239;14702338 Yes 1a1, Direct HQ evidence Matt Weirauch Jussi Taipale Yes $#ENSG00000167074#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IBA - GO_REF:0000033 $#ENSP00000266304#ENSG00000167074#ENST00000266304#bZIP#$#ENSP00000385256#ENSG00000167074#ENST00000406644#bZIP#$#ENSP00000411170#ENSG00000167074#ENST00000413942#bZIP# FALSE 230 ENSG00000115993 TRAK2 bZIP No Unlikely to be sequence specific TF Not a DNA binding protein No motif None The bZIP domain is only a partial 40AA sequence that will not bind DNA. IPR006933;IPR022154 66008 trafficking kinesin protein 2 [Source:HGNC Symbol;Acc:HGNC:13206] None not tested not tested None None No Yes No No 5a, one of the source datasets predicts is as a TF Arttu Jolma Tim Hughes No None $#ENSP00000328875#ENSG00000115993#ENST00000332624#bZIP#HAP1_N, Milton$#ENSP00000409333#ENSG00000115993#ENST00000430254#bZIP#ERM, HAP1_N$#ENSP00000388254#ENSG00000115993#ENST00000440597#bZIP# FALSE 231 ENSG00000100219 XBP1 bZIP Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR004827; 7494 X-box binding protein 1 [Source:HGNC Symbol;Acc:HGNC:12801] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:2321018 Yes 1a1, Direct HQ evidence Tim Hughes Jussi Taipale Yes $#ENSG00000100219#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IEA - GO_REF:0000019$#ENSG00000100219#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:1903538, PMID:8657566 $#ENSP00000216037#ENSG00000100219#ENST00000216037#bZIP#$#ENSP00000384295#ENSG00000100219#ENST00000405219#bZIP#$#ENSP00000385162#ENSG00000100219#ENST00000403532#bZIP# FALSE 232 ENSG00000267179 AC008770.3 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR001909;IPR007087;IPR015880 None CTD-2006C1.13 None not tested not tested None None No Yes No No 5a, one of the source datasets predicts is as a TF Yimeng Yin Sam Lambert No None $#ENSP00000467286#ENSG00000267179#ENST00000590798#C2H2 ZF Containing Proteins#KRAB, zf-C2H2_4, zf-H2C2_2$#ENSP00000465172#ENSG00000267179#ENST00000591944#C2H2 ZF Containing Proteins#KRAB FALSE 233 ENSG00000233757 AC092835.1 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None KRAB C2H2 Protein None None AC092835.1 None not tested not tested None KRAB C2H2 Protein No No No No Protein added after initial stage, no initial assesment Arttu Jolma Sam Lambert No None None FALSE 234 ENSG00000264668 AC138696.1 C2H2 ZF Yes Known motif Monomer or homomultimer 100 perc ID - in vitro None None IPR007087;IPR015880 None RP13-582O9.6 None not tested not tested None None No Yes No No 5a, one of the source datasets predicts is as a TF Sam Lambert Pratyush Das No None $#ENSP00000428966#ENSG00000264668#ENST00000522452#C2H2 ZF Containing Proteins# FALSE 235 ENSG00000139154 AEBP2 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR007087;IPR015880 121536 AE binding protein 2 [Source:HGNC Symbol;Acc:HGNC:24051] None DBD and Full not tested None None b Yes No No 4a, two or more datasets predict it as a TF Pratyush Das Jussi Taipale Yes $#ENSG00000139154#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019 $#ENSP00000266508#ENSG00000139154#ENST00000266508#C2H2 ZF Containing Proteins#$#ENSP00000381840#ENSG00000139154#ENST00000398864#C2H2 ZF Containing Proteins#$#ENSP00000354267#ENSG00000139154#ENST00000360995#C2H2 ZF Containing Proteins#$#ENSP00000381715#ENSG00000139154#ENST00000398731#C2H2 ZF Containing Proteins#$#ENSP00000445587#ENSG00000139154#ENST00000512223#C2H2 ZF Containing Proteins#$#ENSP00000437983#ENSG00000139154#ENST00000541908#C2H2 ZF Containing Proteins# FALSE 236 ENSG00000105127 AKAP8 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif Single C2H2 domain (PMID: 26683827) uses SELEX to show binding to G/C rich DNA, and confirms association with rDNA promoters. Also claims it has a C2H2 domain. Interpro says it has a C2H2 AKAP95-type 1 and a C2H2 AKAP95-type 2 domain. SMART does identify a single C2H2 domain. IPR007071; 10270 A-kinase anchoring protein 8 [Source:HGNC Symbol;Acc:HGNC:378] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Jussi Taipale Pratyush Das No None $#ENSP00000269701#ENSG00000105127#ENST00000269701#Other#AKAP95, zf-C2H2_2 FALSE 237 ENSG00000011243 AKAP8L C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif Single C2H2 domain This is homologous to the AKAP8/AKAP95 protein. which has been shown by SELEX to bind GC rich sequences (PMID: 26683827). IPR007071; 26993 A-kinase anchoring protein 8 like [Source:HGNC Symbol;Acc:HGNC:29857] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Tim Hughes Pratyush Das No None $#ENSP00000380557#ENSG00000011243#ENST00000397410#Other#AKAP95$#ENSP00000470952#ENSG00000011243#ENST00000595465#Other#AKAP95 FALSE 238 ENSG00000163516 ANKZF1 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif Single C2H2 domain None IPR002110;IPR007087;IPR020683; 55139 ankyrin repeat and zinc finger domain containing 1 [Source:HGNC Symbol;Acc:HGNC:25527] None Full not tested None None c No No No 5a, one of the source datasets predicts is as a TF Yimeng Yin Pratyush Das No None $#ENSP00000321617#ENSG00000163516#ENST00000323348#Other#Ank, Ank_2, Ank_3, Ank_4, Ank_5$#ENSP00000386815#ENSG00000163516#ENST00000409849#Other#Ank, Ank_2, Ank_3, Ank_4, Ank_5$#ENSP00000386337#ENSG00000163516#ENST00000410034#Other#Ank, Ank_2, Ank_3, Ank_4, Ank_5$#ENSP00000394652#ENSG00000163516#ENST00000436226#Other#$#ENSP00000394359#ENSG00000163516#ENST00000453432#Other# FALSE 239 ENSG00000166454 ATMIN C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR007087;IPR015880 23300 ATM interactor [Source:HGNC Symbol;Acc:HGNC:29034] None not tested not tested None None x Yes No No 4a, two or more datasets predict it as a TF Sam Lambert Arttu Jolma No None $#ENSP00000299575#ENSG00000166454#ENST00000299575#C2H2 ZF Containing Proteins#$#ENSP00000463478#ENSG00000166454#ENST00000564241#C2H2 ZF Containing Proteins#$#ENSP00000455497#ENSG00000166454#ENST00000566488#C2H2 ZF Containing Proteins#$#ENSP00000464427#ENSG00000166454#ENST00000565237#C2H2 ZF Containing Proteins# FALSE 240 ENSG00000119866 BCL11A C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source None None IPR007087;IPR015880 53335 B-cell CLL/lymphoma 11A [Source:HGNC Symbol;Acc:HGNC:13221] None Full not tested None None b Yes No Yes 2a1, Lower confidence direct evidence Arttu Jolma Tim Hughes Yes $#ENSG00000119866#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:19153051 $#ENSP00000338774#ENSG00000119866#ENST00000335712#C2H2 ZF Containing Proteins#$#ENSP00000349300#ENSG00000119866#ENST00000356842#C2H2 ZF Containing Proteins#$#ENSP00000351307#ENSG00000119866#ENST00000358510#C2H2 ZF Containing Proteins#$#ENSP00000352648#ENSG00000119866#ENST00000359629#C2H2 ZF Containing Proteins#$#ENSP00000487844#ENSG00000119866#ENST00000409351#C2H2 ZF Containing Proteins# FALSE 241 ENSG00000127152 BCL11B C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR007087;IPR015880 64919 B-cell CLL/lymphoma 11B [Source:HGNC Symbol;Acc:HGNC:13222] None DBD not tested None None a Yes No Yes 1a1, Direct HQ evidence Sam Lambert Laura Campitelli Yes $#ENSG00000127152#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IBA - GO_REF:0000033 $#ENSP00000280435#ENSG00000127152#ENST00000345514#C2H2 ZF Containing Proteins#$#ENSP00000349723#ENSG00000127152#ENST00000357195#C2H2 ZF Containing Proteins#$#ENSP00000387419#ENSG00000127152#ENST00000443726#C2H2 ZF Containing Proteins# FALSE 242 ENSG00000113916 BCL6 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000210;IPR007087;IPR011333;IPR013069;IPR015880; 604 B-cell CLL/lymphoma 6 [Source:HGNC Symbol;Acc:HGNC:1001] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:12097386;15659391 Yes 1a1, Direct HQ evidence Jussi Taipale Tim Hughes Yes $#ENSG00000113916#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IEA - GO_REF:0000019$#ENSG00000113916#GO:0003700#sequence-specific DNA binding transcription factor activity#IMP - PMID:15577913 $#ENSP00000232014#ENSG00000113916#ENST00000232014#C2H2 ZF Containing Proteins#BTB, DZR$#ENSP00000384371#ENSG00000113916#ENST00000406870#C2H2 ZF Containing Proteins#BTB, DZR$#ENSP00000413122#ENSG00000113916#ENST00000450123#C2H2 ZF Containing Proteins#BTB, DZR$#ENSP00000415574#ENSG00000113916#ENST00000430339#C2H2 ZF Containing Proteins#BTB, DUF3342$#ENSP00000414455#ENSG00000113916#ENST00000438077#C2H2 ZF Containing Proteins#BTB FALSE 243 ENSG00000161940 BCL6B C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000210;IPR007087;IPR011333;IPR013069;IPR015880; 255877 B-cell CLL/lymphoma 6B [Source:HGNC Symbol;Acc:HGNC:1002] None DBD and Full Yes None None a Yes No No 1a1, Direct HQ evidence Arttu Jolma Pratyush Das Yes $#ENSG00000161940#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IEA - GO_REF:0000019 $#ENSP00000293805#ENSG00000161940#ENST00000293805#C2H2 ZF Containing Proteins#BTB$#ENSP00000460282#ENSG00000161940#ENST00000573503#C2H2 ZF Containing Proteins#BTB$#ENSP00000445010#ENSG00000161940#ENST00000537931#C2H2 ZF Containing Proteins#$#ENSP00000460071#ENSG00000161940#ENST00000576705#C2H2 ZF Containing Proteins#BTB FALSE 244 ENSG00000169594 BNC1 C2H2 ZF Yes Inferred motif Monomer or homomultimer In vivo/Misc source None None IPR007087;IPR015880 646 basonuclin 1 [Source:HGNC Symbol;Acc:HGNC:1081] None not tested not tested None None a Yes No Yes 2a2, orthologous lower confidence evidence Arttu Jolma Yimeng Yin Yes $#ENSG00000169594#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:9099851 $#ENSP00000307041#ENSG00000169594#ENST00000345382#C2H2 ZF Containing Proteins#zf-C2H2_aberr$#ENSP00000456727#ENSG00000169594#ENST00000569704#C2H2 ZF Containing Proteins#zf-C2H2_aberr FALSE 245 ENSG00000173068 BNC2 C2H2 ZF Yes Inferred motif Monomer or homomultimer In vivo/Misc source Has a putative AT-hook None IPR007087;IPR007527;IPR015880; 54796 basonuclin 2 [Source:HGNC Symbol;Acc:HGNC:30988] None DBD not tested None None b Yes No No 2a2, orthologous lower confidence evidence Yimeng Yin Pratyush Das Yes None $#ENSP00000392212#ENSG00000173068#ENST00000411752#C2H2 ZF Containing Proteins#$#ENSP00000444640#ENSG00000173068#ENST00000545497#C2H2 ZF Containing Proteins#$#ENSP00000474045#ENSG00000173068#ENST00000603713#C2H2 ZF Containing Proteins#$#ENSP00000477717#ENSG00000173068#ENST00000613349#C2H2 ZF Containing Proteins#$#ENSP00000482793#ENSG00000173068#ENST00000617779#C2H2 ZF Containing Proteins#$#ENSP00000370047#ENSG00000173068#ENST00000380672#C2H2 ZF Containing Proteins#$#ENSP00000474647#ENSG00000173068#ENST00000486514#C2H2 ZF Containing Proteins#$#ENSP00000474468#ENSG00000173068#ENST00000468187#C2H2 ZF Containing Proteins#$#ENSP00000474832#ENSG00000173068#ENST00000471301#C2H2 ZF Containing Proteins# FALSE 246 ENSG00000130940 CASZ1 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR007087;IPR015880 54897 castor zinc finger 1 [Source:HGNC Symbol;Acc:HGNC:26002] None not tested Yes None None b No No No 5a, one of the source datasets predicts is as a TF Sam Lambert Pratyush Das Yes None $#ENSP00000366221#ENSG00000130940#ENST00000377022#C2H2 ZF Containing Proteins#RNA_pol_3_Rpc31$#ENSP00000339445#ENSG00000130940#ENST00000344008#C2H2 ZF Containing Proteins#$#ENSP00000467769#ENSG00000130940#ENST00000447850#C2H2 ZF Containing Proteins# FALSE 247 ENSG00000159588 CCDC17 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif Single C2H2 domain None None 149483 coiled-coil domain containing 17 [Source:HGNC Symbol;Acc:HGNC:26574] None not tested not tested None None No Yes No No 5a, one of the source datasets predicts is as a TF Jussi Taipale Arttu Jolma No None $#ENSP00000411335#ENSG00000159588#ENST00000445048#C2H2 ZF Containing Proteins#$#ENSP00000389415#ENSG00000159588#ENST00000421127#C2H2 ZF Containing Proteins#$#ENSP00000432172#ENSG00000159588#ENST00000528266#C2H2 ZF Containing Proteins# FALSE 248 ENSG00000198824 CHAMP1 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif Single C2H2 domain None IPR007087;IPR015880 283489 chromosome alignment maintaining phosphoprotein 1 [Source:HGNC Symbol;Acc:HGNC:20311] None not tested not tested None None c No No No 5a, one of the source datasets predicts is as a TF Sam Lambert Jussi Taipale No None $#ENSP00000354730#ENSG00000198824#ENST00000361283#C2H2 ZF Containing Proteins#$#ENSP00000474448#ENSG00000198824#ENST00000463003#C2H2 ZF Containing Proteins#zf-H2C2_5 FALSE 249 ENSG00000147183 CPXCR1 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif Single C2H2 domain None IPR007087; 53336 CPX chromosome region, candidate 1 [Source:HGNC Symbol;Acc:HGNC:2332] None not tested not tested None None c No No No 5a, one of the source datasets predicts is as a TF Sam Lambert Yimeng Yin No None $#ENSP00000276127#ENSG00000147183#ENST00000276127#C2H2 ZF Containing Proteins#zf-C2H2_4, zf-C2H2_6, zf-C2H2_jaz$#ENSP00000484986#ENSG00000147183#ENST00000614120#C2H2 ZF Containing Proteins#zf-C2H2_4, zf-C2H2_6, zf-C2H2_jaz$#ENSP00000362203#ENSG00000147183#ENST00000373111#C2H2 ZF Containing Proteins#zf-C2H2_4, zf-C2H2_6, zf-C2H2_jaz FALSE 250 ENSG00000102974 CTCF C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro Has a putative AT-hook None IPR007087;IPR015880 10664 CCCTC-binding factor [Source:HGNC Symbol;Acc:HGNC:13723] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:8246978;15143173 Yes 1a1, Direct HQ evidence Tim Hughes Arttu Jolma Yes $#ENSG00000102974#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:8649389$#ENSG00000102974#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IEA - GO_REF:0000019$#ENSG00000102974#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:8649389, PMID:9591631 $#ENSP00000264010#ENSG00000102974#ENST00000264010#C2H2 ZF Containing Proteins#$#ENSP00000384707#ENSG00000102974#ENST00000401394#C2H2 ZF Containing Proteins# FALSE 251 ENSG00000124092 CTCFL C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source None None IPR007087;IPR015880 140690 CCCTC-binding factor like [Source:HGNC Symbol;Acc:HGNC:16234] None DBD and Full not tested None None a Yes No Yes 2a1, Lower confidence direct evidence Jussi Taipale Yimeng Yin Yes $#ENSG00000124092#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:16140944 $#ENSP00000243914#ENSG00000124092#ENST00000243914#C2H2 ZF Containing Proteins#$#ENSP00000360239#ENSG00000124092#ENST00000371196#C2H2 ZF Containing Proteins#$#ENSP00000399061#ENSG00000124092#ENST00000422869#C2H2 ZF Containing Proteins#$#ENSP00000415579#ENSG00000124092#ENST00000423479#C2H2 ZF Containing Proteins#$#ENSP00000415329#ENSG00000124092#ENST00000429804#C2H2 ZF Containing Proteins#$#ENSP00000409344#ENSG00000124092#ENST00000432255#C2H2 ZF Containing Proteins#$#ENSP00000392034#ENSG00000124092#ENST00000433949#C2H2 ZF Containing Proteins#$#ENSP00000476577#ENSG00000124092#ENST00000481655#C2H2 ZF Containing Proteins#$#ENSP00000437999#ENSG00000124092#ENST00000502686#C2H2 ZF Containing Proteins#$#ENSP00000439998#ENSG00000124092#ENST00000539382#C2H2 ZF Containing Proteins#$#ENSP00000477165#ENSG00000124092#ENST00000608158#C2H2 ZF Containing Proteins#$#ENSP00000476783#ENSG00000124092#ENST00000608263#C2H2 ZF Containing Proteins#$#ENSP00000476458#ENSG00000124092#ENST00000608425#C2H2 ZF Containing Proteins#$#ENSP00000477488#ENSG00000124092#ENST00000608440#C2H2 ZF Containing Proteins#$#ENSP00000476718#ENSG00000124092#ENST00000608903#C2H2 ZF Containing Proteins#$#ENSP00000476398#ENSG00000124092#ENST00000609232#C2H2 ZF Containing Proteins# FALSE 252 ENSG00000011332 DPF1 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None This protein contains C2H2 ZFs missed by Pfam scanning. IPR001965;IPR007087;IPR011011;IPR015880;IPR019787;IPR025750 8193 double PHD fingers 1 [Source:HGNC Symbol;Acc:HGNC:20225] None DBD and Full not tested None None b Yes No No 1a1, Direct HQ evidence Sam Lambert Jussi Taipale No None $#ENSP00000347716#ENSG00000011332#ENST00000355526#Other#PHD, Requiem_N$#ENSP00000412098#ENSG00000011332#ENST00000412732#Other#PHD, Requiem_N$#ENSP00000397354#ENSG00000011332#ENST00000420980#Other#PHD, Requiem_N$#ENSP00000483226#ENSG00000011332#ENST00000614244#Other#PHD, Requiem_N$#ENSP00000391884#ENSG00000011332#ENST00000414789#Other#PHD, Requiem_N FALSE 253 ENSG00000205683 DPF3 C2H2 ZF Yes Inferred motif Monomer or homomultimer High-throughput in vitro Single C2H2 domain Single C2H2 ZF. PHD domains mediate recognition of acetylated histones (PMID: 20613843); unclear if the ZF contributes DNA-binding specificity to the interaction. IPR001965;IPR007087;IPR011011;IPR015880;IPR019787;IPR025750 8110 double PHD fingers 3 [Source:HGNC Symbol;Acc:HGNC:17427] None not tested not tested None None x Yes No No 4a, two or more datasets predict it as a TF Sam Lambert Jussi Taipale No None $#ENSP00000441640#ENSG00000205683#ENST00000541685#C2H2 ZF Containing Proteins#Lar_restr_allev, PHD, Requiem_N$#ENSP00000450518#ENSG00000205683#ENST00000556509#C2H2 ZF Containing Proteins#PHD, PHD_4, Requiem_N$#ENSP00000444662#ENSG00000205683#ENST00000546183#C2H2 ZF Containing Proteins#Lar_restr_allev, PHD, Requiem_N$#ENSP00000479526#ENSG00000205683#ENST00000610283#C2H2 ZF Containing Proteins#Lar_restr_allev, PHD, Requiem_N FALSE 254 ENSG00000134874 DZIP1 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif Single C2H2 domain; Has a putative AT-hook None IPR007087;IPR015880 22873 DAZ interacting zinc finger protein 1 [Source:HGNC Symbol;Acc:HGNC:20908] None Full not tested None None x Yes No No 4a, two or more datasets predict it as a TF Jussi Taipale Tim Hughes No None $#ENSP00000355018#ENSG00000134874#ENST00000361156#C2H2 ZF Containing Proteins#Dzip-like_N$#ENSP00000355175#ENSG00000134874#ENST00000361396#C2H2 ZF Containing Proteins#Dzip-like_N$#ENSP00000366025#ENSG00000134874#ENST00000376829#C2H2 ZF Containing Proteins#Dzip-like_N$#ENSP00000257312#ENSG00000134874#ENST00000347108#C2H2 ZF Containing Proteins#Dzip-like_N FALSE 255 ENSG00000167967 E4F1 C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain None IPR007087;IPR015880 1877 E4F transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:3121] None DBD and Full Yes None None a Yes TF Gene Candidate__DNA Binding_PMIDS:2169022 Yes 2a1, Lower confidence direct evidence Arttu Jolma Jussi Taipale Yes $#ENSG00000167967#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IC - GO_REF:0000036$#ENSG00000167967#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:10869426, PMID:9121437 $#ENSP00000301727#ENSG00000167967#ENST00000301727#C2H2 ZF Containing Proteins#$#ENSP00000457672#ENSG00000167967#ENST00000564139#C2H2 ZF Containing Proteins#$#ENSP00000456760#ENSG00000167967#ENST00000565090#C2H2 ZF Containing Proteins#$#ENSP00000454652#ENSG00000167967#ENST00000565413#C2H2 ZF Containing Proteins# FALSE 256 ENSG00000102189 EEA1 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif Single C2H2 domain Based on (PMID: 20534488), the protein has a C2H2 ZF domain; but it uses the domain for contacting RAB5A rather than for binding DNA. IPR000306;IPR007087;IPR011011;IPR017455 8411 early endosome antigen 1 [Source:HGNC Symbol;Acc:HGNC:3185] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Arttu Jolma Pratyush Das No None $#ENSP00000317955#ENSG00000102189#ENST00000322349#Other#Atg14, FYVE$#ENSP00000446785#ENSG00000102189#ENST00000549790#Other# FALSE 257 ENSG00000120738 EGR1 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR007087;IPR015880;IPR021839;IPR021849 1958 early growth response 1 [Source:HGNC Symbol;Acc:HGNC:3238] 1A1F DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:8336701;9858508;10049687 Yes 1a1, Direct HQ evidence Jussi Taipale Arttu Jolma Yes $#ENSG00000120738#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000120738#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:12560508 $#ENSP00000239938#ENSG00000120738#ENST00000239938#C2H2 ZF Containing Proteins#Cornifin, DUF3432, DUF3446 FALSE 258 ENSG00000122877 EGR2 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None Binds HOX4A promoter (PMID:21836637) IPR007087;IPR015880;IPR021849; 1959 early growth response 2 [Source:HGNC Symbol;Acc:HGNC:3239] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:12687019 Yes 1a1, Direct HQ evidence Yimeng Yin Laura Campitelli Yes $#ENSG00000122877#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:12687019$#ENSG00000122877#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:14532282 $#ENSP00000242480#ENSG00000122877#ENST00000242480#C2H2 ZF Containing Proteins#DUF3446$#ENSP00000402040#ENSG00000122877#ENST00000439032#C2H2 ZF Containing Proteins#DUF3446$#ENSP00000387634#ENSG00000122877#ENST00000411732#C2H2 ZF Containing Proteins#DUF3446$#ENSP00000490154#ENSG00000122877#ENST00000637191#C2H2 ZF Containing Proteins#DUF3446 FALSE 259 ENSG00000179388 EGR3 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR007087;IPR015880;IPR021849; 1960 early growth response 3 [Source:HGNC Symbol;Acc:HGNC:3240] None DBD and Full Yes None None a Yes TF Gene Candidate_DNA-Binding: sequence-specific_Transactivation_PMIDS:1906159 Yes 1a1, Direct HQ evidence Jussi Taipale Arttu Jolma Yes $#ENSG00000179388#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:1906159, PMID:9731539 $#ENSP00000318057#ENSG00000179388#ENST00000317216#C2H2 ZF Containing Proteins#DUF3446$#ENSP00000430310#ENSG00000179388#ENST00000522910#C2H2 ZF Containing Proteins#DUF3446$#ENSP00000429370#ENSG00000179388#ENST00000519492#C2H2 ZF Containing Proteins# FALSE 260 ENSG00000135625 EGR4 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR007087;IPR015880 1961 early growth response 4 [Source:HGNC Symbol;Acc:HGNC:3241] None DBD not tested None None b Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:17192429 Yes 1a1, Direct HQ evidence Tim Hughes Laura Campitelli Yes $#ENSG00000135625#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:1584812 $#ENSP00000419687#ENSG00000135625#ENST00000436467#C2H2 ZF Containing Proteins#$#ENSP00000445626#ENSG00000135625#ENST00000545030#C2H2 ZF Containing Proteins# FALSE 261 ENSG00000164334 FAM170A C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif Single C2H2 domain Degenerate C2H2-ZFP. Localizes to the nucleus and overexpression upregulates other genes (PMID: 20162441). None 340069 family with sequence similarity 170 member A [Source:HGNC Symbol;Acc:HGNC:27963] None DBD and Full not tested None None b No No No 5a, one of the source datasets predicts is as a TF Jussi Taipale Laura Campitelli No None $#ENSP00000423697#ENSG00000164334#ENST00000509264#Other#$#ENSP00000422684#ENSG00000164334#ENST00000515256#Other#$#ENSP00000482552#ENSG00000164334#ENST00000613773#Other#$#ENSP00000483075#ENSG00000164334#ENST00000620555#Other# FALSE 262 ENSG00000128610 FEZF1 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR007087;IPR015880 389549 FEZ family zinc finger 1 [Source:HGNC Symbol;Acc:HGNC:22788] None Full not tested None None c Yes No Yes 1a1, Direct HQ evidence Jussi Taipale Laura Campitelli Yes $#ENSG00000128610#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IBA - GO_REF:0000033 $#ENSP00000392727#ENSG00000128610#ENST00000427185#C2H2 ZF Containing Proteins#$#ENSP00000411145#ENSG00000128610#ENST00000442488#C2H2 ZF Containing Proteins#$#ENSP00000406919#ENSG00000128610#ENST00000418046#C2H2 ZF Containing Proteins# FALSE 263 ENSG00000153266 FEZF2 C2H2 ZF Yes Inferred motif Monomer or homomultimer High-throughput in vitro None None IPR007087;IPR015880 55079 FEZ family zinc finger 2 [Source:HGNC Symbol;Acc:HGNC:13506] None not tested Yes None None c Yes TF Gene Candidate__DNA Binding_PMIDS:12469125 Yes 1a2, Orthologous HQ evidence Sam Lambert Arttu Jolma Yes $#ENSG00000153266#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IBA - GO_REF:0000033$#ENSG00000153266#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IEA - GO_REF:0000019 $#ENSP00000283268#ENSG00000153266#ENST00000283268#C2H2 ZF Containing Proteins#$#ENSP00000418804#ENSG00000153266#ENST00000475839#C2H2 ZF Containing Proteins#$#ENSP00000418589#ENSG00000153266#ENST00000486811#C2H2 ZF Containing Proteins# FALSE 264 ENSG00000179943 FIZ1 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Protein has a decent cassette of C2H2 ZF domains (not all are detected by Pfam). It has been also shown to interact with homeodomain protein CRX (PMID: 18854042) and MAF-subtype bZIP protein NRL (PMID: 12566383). IPR007087;IPR015880 84922 FLT3 interacting zinc finger 1 [Source:HGNC Symbol;Acc:HGNC:25917] None Full not tested None None b Yes No No 4a, two or more datasets predict it as a TF Sam Lambert Arttu Jolma Yes None $#ENSP00000221665#ENSG00000179943#ENST00000221665#C2H2 ZF Containing Proteins#zf-C2H2_4$#ENSP00000465131#ENSG00000179943#ENST00000590714#C2H2 ZF Containing Proteins#$#ENSP00000468342#ENSG00000179943#ENST00000587678#C2H2 ZF Containing Proteins#$#ENSP00000468018#ENSG00000179943#ENST00000587414#C2H2 ZF Containing Proteins# FALSE 265 ENSG00000162676 GFI1 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR007087;IPR015880 2672 growth factor independent 1 transcriptional repressor [Source:HGNC Symbol;Acc:HGNC:4237] 2KMK DBD not tested None 3 znf NMR structure b Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:8754800 Yes 1a1, Direct HQ evidence Jussi Taipale Pratyush Das Yes $#ENSG00000162676#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:19506020$#ENSG00000162676#GO:0032088#negative regulation of NF-kappaB transcription factor activity#ISS - GO_REF:0000024 $#ENSP00000359357#ENSG00000162676#ENST00000370332#C2H2 ZF Containing Proteins#$#ENSP00000399719#ENSG00000162676#ENST00000427103#C2H2 ZF Containing Proteins#$#ENSP00000294702#ENSG00000162676#ENST00000294702#C2H2 ZF Containing Proteins# FALSE 266 ENSG00000165702 GFI1B C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR007087;IPR015880 8328 growth factor independent 1B transcriptional repressor [Source:HGNC Symbol;Acc:HGNC:4238] None DBD and Full not tested None None a Yes No No 1a1, Direct HQ evidence Pratyush Das Jussi Taipale Yes None $#ENSP00000344782#ENSG00000165702#ENST00000339463#C2H2 ZF Containing Proteins#$#ENSP00000361195#ENSG00000165702#ENST00000372122#C2H2 ZF Containing Proteins#$#ENSP00000490303#ENSG00000165702#ENST00000636137#C2H2 ZF Containing Proteins#$#ENSP00000489646#ENSG00000165702#ENST00000636263#C2H2 ZF Containing Proteins# FALSE 267 ENSG00000111087 GLI1 C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source None None IPR007087;IPR015880 2735 GLI family zinc finger 1 [Source:HGNC Symbol;Acc:HGNC:4317] 2GLI DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:10559945;11719506;15087129 No 1a1, Direct HQ evidence Yimeng Yin Tim Hughes Yes $#ENSG00000111087#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019 $#ENSP00000228682#ENSG00000111087#ENST00000228682#C2H2 ZF Containing Proteins#$#ENSP00000434408#ENSG00000111087#ENST00000528467#C2H2 ZF Containing Proteins#$#ENSP00000434421#ENSG00000111087#ENST00000528432#C2H2 ZF Containing Proteins#$#ENSP00000436671#ENSG00000111087#ENST00000532291#C2H2 ZF Containing Proteins# FALSE 268 ENSG00000074047 GLI2 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR007087;IPR015880 2736 GLI family zinc finger 2 [Source:HGNC Symbol;Acc:HGNC:4318] None DBD Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_Transactivation_PMIDS:2850480;3563490 Yes 1a1, Direct HQ evidence Arttu Jolma Laura Campitelli Yes $#ENSG00000074047#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000074047#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:15994174 $#ENSP00000441454#ENSG00000074047#ENST00000360874#C2H2 ZF Containing Proteins#$#ENSP00000354586#ENSG00000074047#ENST00000361492#C2H2 ZF Containing Proteins#$#ENSP00000398992#ENSG00000074047#ENST00000418323#C2H2 ZF Containing Proteins#$#ENSP00000390436#ENSG00000074047#ENST00000452319#C2H2 ZF Containing Proteins# FALSE 269 ENSG00000106571 GLI3 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR007087;IPR015880 2737 GLI family zinc finger 3 [Source:HGNC Symbol;Acc:HGNC:4319] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:10433919;12435627;16396903 Yes 1a1, Direct HQ evidence Tim Hughes Laura Campitelli Yes $#ENSG00000106571#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IC - GO_REF:0000036$#ENSG00000106571#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:10077605, PMID:17000779, PMID:17764085 $#ENSP00000407963#ENSG00000106571#ENST00000437480#C2H2 ZF Containing Proteins#$#ENSP00000406135#ENSG00000106571#ENST00000448703#C2H2 ZF Containing Proteins#$#ENSP00000379258#ENSG00000106571#ENST00000395925#C2H2 ZF Containing Proteins# FALSE 270 ENSG00000250571 GLI4 C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect Protein is not closely homologous to GLI1-3 proteins. IPR007087;IPR015880 2738 GLI family zinc finger 4 [Source:HGNC Symbol;Acc:HGNC:4320] None not tested not tested None TFs that are in CisBP but not in Vaquerizas set No Yes No Yes 1a1, Direct HQ evidence Arttu Jolma Pratyush Das Yes $#ENSG00000250571#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000345024#ENSG00000250571#ENST00000340042#C2H2 ZF Containing Proteins#$#ENSP00000430987#ENSG00000250571#ENST00000523522#C2H2 ZF Containing Proteins#$#ENSP00000344727#ENSG00000250571#ENST00000344692#C2H2 ZF Containing Proteins#$#ENSP00000429514#ENSG00000250571#ENST00000517530#C2H2 ZF Containing Proteins#$#ENSP00000427881#ENSG00000250571#ENST00000520021#C2H2 ZF Containing Proteins#$#ENSP00000430292#ENSG00000250571#ENST00000521682#C2H2 ZF Containing Proteins# FALSE 271 ENSG00000174332 GLIS1 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR007087;IPR015880 148979 GLIS family zinc finger 1 [Source:HGNC Symbol;Acc:HGNC:29525] None DBD not tested None None a Yes No No 1a1, Direct HQ evidence Laura Campitelli Arttu Jolma Yes $#ENSG00000174332#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IEA - GO_REF:0000019$#ENSG00000174332#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IEA - GO_REF:0000019 $#ENSP00000309653#ENSG00000174332#ENST00000312233#C2H2 ZF Containing Proteins#$#ENSP00000486112#ENSG00000174332#ENST00000628545#C2H2 ZF Containing Proteins# FALSE 272 ENSG00000126603 GLIS2 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR007087;IPR015880 84662 GLIS family zinc finger 2 [Source:HGNC Symbol;Acc:HGNC:29450] None DBD Yes None None b Yes TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_Transactivation_PMIDS:11741991;16326862 No 1a1, Direct HQ evidence Tim Hughes Arttu Jolma Yes $#ENSG00000126603#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#ISS - GO_REF:0000024$#ENSG00000126603#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024 $#ENSP00000395547#ENSG00000126603#ENST00000433375#C2H2 ZF Containing Proteins#FOXP-CC$#ENSP00000262366#ENSG00000126603#ENST00000262366#C2H2 ZF Containing Proteins#FOXP-CC FALSE 273 ENSG00000107249 GLIS3 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR007087;IPR015880 169792 GLIS family zinc finger 3 [Source:HGNC Symbol;Acc:HGNC:28510] None DBD and Full not tested None None b Yes No No 1a1, Direct HQ evidence Tim Hughes Jussi Taipale Yes None $#ENSP00000325494#ENSG00000107249#ENST00000324333#C2H2 ZF Containing Proteins#$#ENSP00000418671#ENSG00000107249#ENST00000462164#C2H2 ZF Containing Proteins#$#ENSP00000417794#ENSG00000107249#ENST00000477901#C2H2 ZF Containing Proteins#$#ENSP00000418995#ENSG00000107249#ENST00000478315#C2H2 ZF Containing Proteins#$#ENSP00000418005#ENSG00000107249#ENST00000478844#C2H2 ZF Containing Proteins#$#ENSP00000417883#ENSG00000107249#ENST00000481827#C2H2 ZF Containing Proteins# FALSE 274 ENSG00000122034 GTF3A C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR007087;IPR015880 2971 General transcription factor IIIA [Source:HGNC Symbol;Acc:HGNC:4662] 1TF3 not tested Yes None 3 ZNF NMR structure x Yes No No 1a1, Direct HQ evidence Pratyush Das Jussi Taipale Yes None $#ENSP00000370532#ENSG00000122034#ENST00000381140#C2H2 ZF Containing Proteins# FALSE 275 ENSG00000125812 GZF1 C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain None IPR000210;IPR007087;IPR011333;IPR013069;IPR015880; 64412 GDNF inducible zinc finger protein 1 [Source:HGNC Symbol;Acc:HGNC:15808] None not tested not tested None None b Yes No Yes 2a1, Lower confidence direct evidence Tim Hughes Pratyush Das Yes $#ENSG00000125812#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:16049025 | IMP - PMID:16049025$#ENSG00000125812#GO:0001206#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involv#IDA - PMID:16049025 | IMP - PMID:16049025 $#ENSP00000338290#ENSG00000125812#ENST00000338121#C2H2 ZF Containing Proteins#BTB, zf-C2H2_4, zf-C2H2_6, zf-H2C2_2, zf-met$#ENSP00000366250#ENSG00000125812#ENST00000377051#C2H2 ZF Containing Proteins#BTB, zf-C2H2_4, zf-C2H2_6, zf-H2C2_2, zf-met$#ENSP00000410009#ENSG00000125812#ENST00000424216#C2H2 ZF Containing Proteins# FALSE 276 ENSG00000177374 HIC1 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000210;IPR007087;IPR011333;IPR013069;IPR015880; 3090 hypermethylated in cancer 1 [Source:HGNC Symbol;Acc:HGNC:4909] None DBD Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:15231840 Yes 1a1, Direct HQ evidence Laura Campitelli Arttu Jolma Yes $#ENSG00000177374#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:15231840 | TAS - PMID:7585125 $#ENSP00000382742#ENSG00000177374#ENST00000399849#C2H2 ZF Containing Proteins#BTB$#ENSP00000476554#ENSG00000177374#ENST00000571875#C2H2 ZF Containing Proteins#BTB$#ENSP00000460268#ENSG00000177374#ENST00000571990#C2H2 ZF Containing Proteins#BTB$#ENSP00000461476#ENSG00000177374#ENST00000574370#C2H2 ZF Containing Proteins#$#ENSP00000477858#ENSG00000177374#ENST00000619757#C2H2 ZF Containing Proteins#BTB$#ENSP00000467045#ENSG00000177374#ENST00000576444#C2H2 ZF Containing Proteins#BTB FALSE 277 ENSG00000169635 HIC2 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000210;IPR007087;IPR011333;IPR013069;IPR015880; 23119 hypermethylated in cancer 2 [Source:HGNC Symbol;Acc:HGNC:18595] None DBD not tested None None a Yes No No 1a1, Direct HQ evidence Yimeng Yin Laura Campitelli Yes None $#ENSP00000385319#ENSG00000169635#ENST00000407464#C2H2 ZF Containing Proteins#BTB$#ENSP00000384889#ENSG00000169635#ENST00000407598#C2H2 ZF Containing Proteins#BTB$#ENSP00000387757#ENSG00000169635#ENST00000443632#C2H2 ZF Containing Proteins#BTB FALSE 278 ENSG00000172273 HINFP C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR007087;IPR015880 25988 histone H4 transcription factor [Source:HGNC Symbol;Acc:HGNC:17850] None DBD and Full not tested None Jolma2013 HT-SELEX model has erroneous symbol HINFP1 a Yes No Yes 1a1, Direct HQ evidence Yimeng Yin Jussi Taipale Yes $#ENSG00000172273#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000172273#GO:0003700#sequence-specific DNA binding transcription factor activity#IMP - PMID:9540062 $#ENSP00000318085#ENSG00000172273#ENST00000350777#C2H2 ZF Containing Proteins#zf-C2H2_4$#ENSP00000436815#ENSG00000172273#ENST00000527410#C2H2 ZF Containing Proteins#zf-C2H2_4$#ENSP00000433836#ENSG00000172273#ENST00000530678#C2H2 ZF Containing Proteins#$#ENSP00000431468#ENSG00000172273#ENST00000529988#C2H2 ZF Containing Proteins# FALSE 279 ENSG00000095951 HIVEP1 C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain None IPR007087;IPR015880 3096 Human immunodeficiency virus type I enhancer binding protein 1 [Source:HGNC Symbol;Acc:HGNC:4920] None not tested not tested None None a Yes No No 2a1, Lower confidence direct evidence Tim Hughes Jussi Taipale Yes $#ENSG00000095951#GO:0001206#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involv#IBA - GO_REF:0000033 $#ENSP00000368698#ENSG00000095951#ENST00000379388#C2H2 ZF Containing Proteins#$#ENSP00000419721#ENSG00000095951#ENST00000484210#C2H2 ZF Containing Proteins#$#ENSP00000417348#ENSG00000095951#ENST00000487103#C2H2 ZF Containing Proteins#$#ENSP00000409078#ENSG00000095951#ENST00000442081#C2H2 ZF Containing Proteins#$#ENSP00000419762#ENSG00000095951#ENST00000491710#C2H2 ZF Containing Proteins# FALSE 280 ENSG00000010818 HIVEP2 C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain None IPR007087;IPR015880 3097 human immunodeficiency virus type I enhancer binding protein 2 [Source:HGNC Symbol;Acc:HGNC:4921] None not tested not tested None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:10207097 Yes 2a1, Lower confidence direct evidence Sam Lambert Jussi Taipale Yes $#ENSG00000010818#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000356575#ENSG00000010818#ENST00000367603#C2H2 ZF Containing Proteins#$#ENSP00000012134#ENSG00000010818#ENST00000012134#C2H2 ZF Containing Proteins#$#ENSP00000356576#ENSG00000010818#ENST00000367604#C2H2 ZF Containing Proteins# FALSE 281 ENSG00000127124 HIVEP3 C2H2 ZF Yes Inferred motif Monomer or homomultimer In vivo/Misc source Has a putative AT-hook Binds to NFKB-like consensus sequence to repress transcription (PMID: 21189157). PWMs for HIVEP1 and 2 in Transfac and Hocomoco are also NFKB-like. IPR007087;IPR015880 59269 human immunodeficiency virus type I enhancer binding protein 3 [Source:HGNC Symbol;Acc:HGNC:13561] None not tested not tested None None a Yes No Yes 2a2, orthologous lower confidence evidence Pratyush Das Arttu Jolma Yes $#ENSG00000127124#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000361664#ENSG00000127124#ENST00000372583#C2H2 ZF Containing Proteins#$#ENSP00000361665#ENSG00000127124#ENST00000372584#C2H2 ZF Containing Proteins# FALSE 282 ENSG00000181666 HKR1 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 284459 HKR1, GLI-Kruppel zinc finger family member [Source:HGNC Symbol;Acc:HGNC:4928] None Full not tested None None b Yes No No 1a1, Direct HQ evidence Sam Lambert Arttu Jolma Yes None $#ENSP00000315505#ENSG00000181666#ENST00000324411#C2H2 ZF Containing Proteins#KRAB, zf-C2H2_11, zf-C2H2_4$#ENSP00000375994#ENSG00000181666#ENST00000392153#C2H2 ZF Containing Proteins#KRAB, zf-C2H2_11, zf-C2H2_4$#ENSP00000438261#ENSG00000181666#ENST00000541583#C2H2 ZF Containing Proteins#zf-C2H2_11, zf-C2H2_4$#ENSP00000466472#ENSG00000181666#ENST00000591259#C2H2 ZF Containing Proteins#KRAB$#ENSP00000437774#ENSG00000181666#ENST00000544914#C2H2 ZF Containing Proteins#$#ENSP00000467562#ENSG00000181666#ENST00000589392#C2H2 ZF Containing Proteins#KRAB, zf-C2H2_11, zf-C2H2_4$#ENSP00000468572#ENSG00000181666#ENST00000590166#C2H2 ZF Containing Proteins#$#ENSP00000466856#ENSG00000181666#ENST00000591134#C2H2 ZF Containing Proteins#$#ENSP00000466467#ENSG00000181666#ENST00000591471#C2H2 ZF Containing Proteins#$#ENSP00000468528#ENSG00000181666#ENST00000589801#C2H2 ZF Containing Proteins#$#ENSP00000465884#ENSG00000181666#ENST00000592768#C2H2 ZF Containing Proteins# TRUE 283 ENSG00000185811 IKZF1 C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain None IPR007087;IPR015880 10320 IKAROS family zinc finger 1 [Source:HGNC Symbol;Acc:HGNC:13176] None DBD and Full not tested None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:15841184 Yes 2a1, Lower confidence direct evidence Pratyush Das Sam Lambert Yes $#ENSG00000185811#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000331614#ENSG00000185811#ENST00000331340#C2H2 ZF Containing Proteins#zf-C2H2_4$#ENSP00000352123#ENSG00000185811#ENST00000359197#C2H2 ZF Containing Proteins#zf-C2H2_4$#ENSP00000388478#ENSG00000185811#ENST00000413698#C2H2 ZF Containing Proteins#$#ENSP00000409588#ENSG00000185811#ENST00000426121#C2H2 ZF Containing Proteins#$#ENSP00000413025#ENSG00000185811#ENST00000439701#C2H2 ZF Containing Proteins#zf-C2H2_4$#ENSP00000483016#ENSG00000185811#ENST00000612658#C2H2 ZF Containing Proteins#zf-C2H2_4$#ENSP00000396554#ENSG00000185811#ENST00000438033#C2H2 ZF Containing Proteins#zf-C2H2_4 FALSE 284 ENSG00000030419 IKZF2 C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain None IPR007087;IPR015880 22807 IKAROS family zinc finger 2 [Source:HGNC Symbol;Acc:HGNC:13177] None DBD and Full not tested None None b Yes No Yes 2a1, Lower confidence direct evidence Sam Lambert Jussi Taipale Yes $#ENSG00000030419#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000342876#ENSG00000030419#ENST00000342002#C2H2 ZF Containing Proteins#zf-C2H2_4$#ENSP00000363439#ENSG00000030419#ENST00000374319#C2H2 ZF Containing Proteins#zf-C2H2_4$#ENSP00000402132#ENSG00000030419#ENST00000452786#C2H2 ZF Containing Proteins#$#ENSP00000406783#ENSG00000030419#ENST00000433134#C2H2 ZF Containing Proteins# FALSE 285 ENSG00000161405 IKZF3 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR007087;IPR015880 22806 IKAROS family zinc finger 3 [Source:HGNC Symbol;Acc:HGNC:13178] None DBD and Full Yes None None a Yes TF Gene_Transcription Factor Binding: tf co-factor binding; DNA-Binding: sequence-specific_DNA Binding; TF PPI; Transactivation_PMIDS:9155026 Yes 1a1, Direct HQ evidence Laura Campitelli Arttu Jolma Yes $#ENSG00000161405#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IEA - GO_REF:0000019$#ENSG00000161405#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:10552935 $#ENSP00000344544#ENSG00000161405#ENST00000346872#C2H2 ZF Containing Proteins#zf-C2H2_4$#ENSP00000367179#ENSG00000161405#ENST00000377944#C2H2 ZF Containing Proteins#zf-C2H2_4$#ENSP00000367180#ENSG00000161405#ENST00000377945#C2H2 ZF Containing Proteins#$#ENSP00000367188#ENSG00000161405#ENST00000377952#C2H2 ZF Containing Proteins#$#ENSP00000367194#ENSG00000161405#ENST00000377958#C2H2 ZF Containing Proteins#zf-C2H2_4$#ENSP00000377741#ENSG00000161405#ENST00000394189#C2H2 ZF Containing Proteins#$#ENSP00000403776#ENSG00000161405#ENST00000439167#C2H2 ZF Containing Proteins#zf-C2H2_4$#ENSP00000438972#ENSG00000161405#ENST00000535189#C2H2 ZF Containing Proteins#zf-C2H2_4$#ENSP00000485515#ENSG00000161405#ENST00000623724#C2H2 ZF Containing Proteins#$#ENSP00000462452#ENSG00000161405#ENST00000583368#C2H2 ZF Containing Proteins# FALSE 286 ENSG00000123411 IKZF4 C2H2 ZF Yes Inferred motif Monomer or homomultimer In vivo/Misc source None None IPR007087;IPR015880 64375 IKAROS family zinc finger 4 [Source:HGNC Symbol;Acc:HGNC:13179] None DBD not tested None None b Yes No Yes 2a2, orthologous lower confidence evidence Yimeng Yin Tim Hughes Yes $#ENSG00000123411#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:10978333 $#ENSP00000412101#ENSG00000123411#ENST00000431367#C2H2 ZF Containing Proteins#zf-C2H2_4$#ENSP00000450020#ENSG00000123411#ENST00000547791#C2H2 ZF Containing Proteins#zf-C2H2_4$#ENSP00000448419#ENSG00000123411#ENST00000547167#C2H2 ZF Containing Proteins#zf-C2H2_4$#ENSP00000449168#ENSG00000123411#ENST00000552689#C2H2 ZF Containing Proteins# FALSE 287 ENSG00000095574 IKZF5 C2H2 ZF Yes Inferred motif Monomer or homomultimer In vivo/Misc source None None IPR007087;IPR015880 64376 IKAROS family zinc finger 5 [Source:HGNC Symbol;Acc:HGNC:14283] None DBD and Full not tested None None b Yes No Yes 1a1, Direct HQ evidence Yimeng Yin Sam Lambert Yes $#ENSG00000095574#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000357881#ENSG00000095574#ENST00000368886#C2H2 ZF Containing Proteins#$#ENSP00000478056#ENSG00000095574#ENST00000617859#C2H2 ZF Containing Proteins# FALSE 288 ENSG00000173404 INSM1 C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source None None IPR007087;IPR015880 3642 INSM transcriptional repressor 1 [Source:HGNC Symbol;Acc:HGNC:6090] None DBD not tested None Model looks specific a Yes No Yes 2a1, Lower confidence direct evidence Yimeng Yin Jussi Taipale Yes $#ENSG00000173404#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:16569215$#ENSG00000173404#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:11842116, PMID:16569215, PMID:18417529 $#ENSP00000312631#ENSG00000173404#ENST00000310227#C2H2 ZF Containing Proteins# FALSE 289 ENSG00000168348 INSM2 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR007087;IPR015880 84684 INSM transcriptional repressor 2 [Source:HGNC Symbol;Acc:HGNC:17539] None Full not tested None None b Yes No No 4a, two or more datasets predict it as a TF Sam Lambert Yimeng Yin Yes None $#ENSP00000306523#ENSG00000168348#ENST00000307169#C2H2 ZF Containing Proteins# FALSE 290 ENSG00000153814 JAZF1 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR007087;IPR015880 221895 JAZF zinc finger 1 [Source:HGNC Symbol;Acc:HGNC:28917] None DBD and Full not tested None None a Yes No No 4a, two or more datasets predict it as a TF Sam Lambert Pratyush Das No $#ENSG00000153814#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000283928#ENSG00000153814#ENST00000283928#C2H2 ZF Containing Proteins#$#ENSP00000388302#ENSG00000153814#ENST00000427814#C2H2 ZF Containing Proteins#zf-C2H2_4, zf-C2H2_aberr$#ENSP00000387976#ENSG00000153814#ENST00000430432#C2H2 ZF Containing Proteins#zf-C2H2_aberr$#ENSP00000415096#ENSG00000153814#ENST00000447620#C2H2 ZF Containing Proteins#zf-C2H2_aberr FALSE 291 ENSG00000136504 KAT7 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR002515;IPR002717;IPR016181; 11143 lysine acetyltransferase 7 [Source:HGNC Symbol;Acc:HGNC:17016] None not tested not tested None None x Yes No No 4a, two or more datasets predict it as a TF Jussi Taipale Pratyush Das Yes $#ENSG00000136504#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002 $#ENSP00000259021#ENSG00000136504#ENST00000259021#C2H2 ZF Containing Proteins#MOZ_SAS$#ENSP00000398961#ENSG00000136504#ENST00000424009#C2H2 ZF Containing Proteins#MOZ_SAS$#ENSP00000409477#ENSG00000136504#ENST00000435742#C2H2 ZF Containing Proteins#MOZ_SAS$#ENSP00000413415#ENSG00000136504#ENST00000454930#C2H2 ZF Containing Proteins#MOZ_SAS$#ENSP00000424577#ENSG00000136504#ENST00000509773#C2H2 ZF Containing Proteins#MOZ_SAS$#ENSP00000423385#ENSG00000136504#ENST00000510819#C2H2 ZF Containing Proteins#MOZ_SAS FALSE 292 ENSG00000176407 KCMF1 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif Single C2H2 domain No evidence of DNA-binding in the literature; and has evidence of E3 ligase activity (PMID:15581609). IPR000433;IPR007087;IPR008598;IPR015880 56888 potassium channel modulatory factor 1 [Source:HGNC Symbol;Acc:HGNC:20589] None DBD and Full Yes None None b Yes No No 4a, two or more datasets predict it as a TF Sam Lambert Jussi Taipale No None $#ENSP00000386738#ENSG00000176407#ENST00000409785#C2H2 ZF Containing Proteins#Di19_C, ZZ$#ENSP00000409499#ENSG00000176407#ENST00000428691#C2H2 ZF Containing Proteins#$#ENSP00000391340#ENSG00000176407#ENST00000453448#C2H2 ZF Containing Proteins#zf-ribbon_3$#ENSP00000414214#ENSG00000176407#ENST00000456682#C2H2 ZF Containing Proteins# FALSE 293 ENSG00000151657 KIN C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif Single C2H2 domain Binds curved DNA (PMID: 8078469). IPR019447; 22944 Kin17 DNA and RNA binding protein [Source:HGNC Symbol;Acc:HGNC:6327] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Yimeng Yin Arttu Jolma No None $#ENSP00000368881#ENSG00000151657#ENST00000379562#Other#KOW, Kin17_mid FALSE 294 ENSG00000105610 KLF1 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR007087;IPR015880 10661 Kruppel like factor 1 [Source:HGNC Symbol;Acc:HGNC:6345] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:11092887 Yes 1a1, Direct HQ evidence Arttu Jolma Jussi Taipale Yes $#ENSG00000105610#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:8924208, PMID:9778250 $#ENSP00000264834#ENSG00000105610#ENST00000264834#C2H2 ZF Containing Proteins#EKLF_TAD1, EKLF_TAD2 FALSE 295 ENSG00000155090 KLF10 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR007087;IPR015880 7071 Kruppel like factor 10 [Source:HGNC Symbol;Acc:HGNC:11810] None DBD and Full not tested None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:15087465 Yes 1a1, Direct HQ evidence Yimeng Yin Arttu Jolma Yes $#ENSG00000155090#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:10816551, PMID:9748269 $#ENSP00000285407#ENSG00000155090#ENST00000285407#C2H2 ZF Containing Proteins#AAA_33$#ENSP00000379222#ENSG00000155090#ENST00000395884#C2H2 ZF Containing Proteins#AAA_33 FALSE 296 ENSG00000172059 KLF11 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR007087;IPR015880 8462 Kruppel like factor 11 [Source:HGNC Symbol;Acc:HGNC:11811] None DBD and Full Yes None None a Yes No Yes 1a1, Direct HQ evidence Laura Campitelli Arttu Jolma Yes $#ENSG00000172059#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IDA - PMID:21171965$#ENSG00000172059#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:9748269 $#ENSP00000307023#ENSG00000172059#ENST00000305883#C2H2 ZF Containing Proteins#$#ENSP00000388263#ENSG00000172059#ENST00000440320#C2H2 ZF Containing Proteins#$#ENSP00000442722#ENSG00000172059#ENST00000535335#C2H2 ZF Containing Proteins#$#ENSP00000444690#ENSG00000172059#ENST00000540845#C2H2 ZF Containing Proteins#$#ENSP00000386058#ENSG00000172059#ENST00000401510#C2H2 ZF Containing Proteins# FALSE 297 ENSG00000118922 KLF12 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR007087;IPR015880 11278 Kruppel like factor 12 [Source:HGNC Symbol;Acc:HGNC:6346] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Other_PMIDS:9858544 Yes 1a1, Direct HQ evidence Pratyush Das Yimeng Yin Yes $#ENSG00000118922#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IEA - GO_REF:0000019$#ENSG00000118922#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:16615998 $#ENSP00000366897#ENSG00000118922#ENST00000377669#C2H2 ZF Containing Proteins# FALSE 298 ENSG00000169926 KLF13 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR007087;IPR015880 51621 Kruppel like factor 13 [Source:HGNC Symbol;Acc:HGNC:13672] None DBD and Full not tested None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:10642511;16303770 No 1a1, Direct HQ evidence Sam Lambert Pratyush Das Yes $#ENSG00000169926#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019 $#ENSP00000302456#ENSG00000169926#ENST00000307145#C2H2 ZF Containing Proteins#$#ENSP00000452867#ENSG00000169926#ENST00000558844#C2H2 ZF Containing Proteins#$#ENSP00000452609#ENSG00000169926#ENST00000560473#C2H2 ZF Containing Proteins# FALSE 299 ENSG00000266265 KLF14 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR007087;IPR015880 136259 Kruppel like factor 14 [Source:HGNC Symbol;Acc:HGNC:23025] None DBD not tested None None b Yes No No 1a1, Direct HQ evidence Yimeng Yin Pratyush Das Yes None $#ENSP00000463287#ENSG00000266265#ENST00000583337#C2H2 ZF Containing Proteins# FALSE 300 ENSG00000163884 KLF15 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR007087;IPR015880 28999 Kruppel like factor 15 [Source:HGNC Symbol;Acc:HGNC:14536] None DBD and Full not tested None None a Yes TF Gene_DNA-Binding: sequence-specific; Transcription Factor Binding: tf co-factor binding_Co-activation; DNA Binding_PMIDS:12097321;17438289 Yes 1a1, Direct HQ evidence Pratyush Das Arttu Jolma Yes $#ENSG00000163884#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IC - PMID:19767294 $#ENSP00000296233#ENSG00000163884#ENST00000296233#C2H2 ZF Containing Proteins# FALSE 301 ENSG00000129911 KLF16 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR007087;IPR015880 83855 Kruppel like factor 16 [Source:HGNC Symbol;Acc:HGNC:16857] None DBD not tested None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:12036432 Yes 1a1, Direct HQ evidence Sam Lambert Yimeng Yin Yes $#ENSG00000129911#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019 $#ENSP00000483701#ENSG00000129911#ENST00000617223#C2H2 ZF Containing Proteins#$#ENSP00000250916#ENSG00000129911#ENST00000250916#C2H2 ZF Containing Proteins#$#ENSP00000480570#ENSG00000129911#ENST00000592313#C2H2 ZF Containing Proteins# FALSE 302 ENSG00000171872 KLF17 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR007087;IPR015880 128209 Kruppel like factor 17 [Source:HGNC Symbol;Acc:HGNC:18830] None DBD Yes None None b Yes No Yes 1a1, Direct HQ evidence Laura Campitelli Arttu Jolma Yes $#ENSG00000171872#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000171872#GO:0003700#sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024 $#ENSP00000361373#ENSG00000171872#ENST00000372299#C2H2 ZF Containing Proteins# FALSE 303 ENSG00000127528 KLF2 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR007087;IPR015880 10365 Kruppel like factor 2 [Source:HGNC Symbol;Acc:HGNC:6347] None DBD and Full not tested None None a Yes No Yes 1a1, Direct HQ evidence Laura Campitelli Pratyush Das Yes $#ENSG00000127528#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:21063504 $#ENSP00000248071#ENSG00000127528#ENST00000248071#C2H2 ZF Containing Proteins#$#ENSP00000465035#ENSG00000127528#ENST00000592003#C2H2 ZF Containing Proteins# FALSE 304 ENSG00000109787 KLF3 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR007087;IPR015880 51274 Kruppel like factor 3 [Source:HGNC Symbol;Acc:HGNC:16516] None DBD Yes None None b Yes No Yes 1a1, Direct HQ evidence Laura Campitelli Yimeng Yin Yes $#ENSG00000109787#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:10582345 $#ENSP00000261438#ENSG00000109787#ENST00000261438#C2H2 ZF Containing Proteins#$#ENSP00000421252#ENSG00000109787#ENST00000514033#C2H2 ZF Containing Proteins# FALSE 305 ENSG00000136826 KLF4 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR007087;IPR015880 9314 Kruppel like factor 4 [Source:HGNC Symbol;Acc:HGNC:6348] 2WBS DBD and Full not tested None Structure is crystalized with too short DNA and only one of the domains contact DNA properly a Yes No No 1a1, Direct HQ evidence Pratyush Das Jussi Taipale Yes $#ENSG00000136826#GO:0001010#sequence-specific DNA binding transcription factor recruiting transcription factor activity#ISS - GO_REF:0000024$#ENSG00000136826#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IMP - PMID:21539536$#ENSG00000136826#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:9422764$#ENSG00000136826#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IDA - PMID:20551324 $#ENSP00000363804#ENSG00000136826#ENST00000374672#C2H2 ZF Containing Proteins#$#ENSP00000399921#ENSG00000136826#ENST00000411706#C2H2 ZF Containing Proteins#$#ENSP00000404922#ENSG00000136826#ENST00000420475#C2H2 ZF Containing Proteins#$#ENSP00000483629#ENSG00000136826#ENST00000610832#C2H2 ZF Containing Proteins# FALSE 306 ENSG00000102554 KLF5 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None Binds as a monomer and as a dimer (PMID: 25575120). IPR007087;IPR015880 688 Kruppel like factor 5 [Source:HGNC Symbol;Acc:HGNC:6349] None DBD not tested None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:16595680 Yes 1a1, Direct HQ evidence Pratyush Das Sam Lambert Yes $#ENSG00000102554#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:16595680 $#ENSP00000366915#ENSG00000102554#ENST00000377687#C2H2 ZF Containing Proteins#$#ENSP00000440407#ENSG00000102554#ENST00000539231#C2H2 ZF Containing Proteins# FALSE 307 ENSG00000067082 KLF6 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR007087;IPR015880 1316 Kruppel like factor 6 [Source:HGNC Symbol;Acc:HGNC:2235] None DBD and Full not tested None None a Yes No No 1a1, Direct HQ evidence Tim Hughes Pratyush Das Yes None $#ENSP00000419079#ENSG00000067082#ENST00000469435#C2H2 ZF Containing Proteins#$#ENSP00000419923#ENSG00000067082#ENST00000497571#C2H2 ZF Containing Proteins#$#ENSP00000445301#ENSG00000067082#ENST00000542957#C2H2 ZF Containing Proteins# FALSE 308 ENSG00000118263 KLF7 C2H2 ZF Yes Known motif Monomer or homomultimer 100 perc ID - in vitro Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect None IPR007087;IPR015880 8609 Kruppel like factor 7 [Source:HGNC Symbol;Acc:HGNC:6350] None DBD and Full Yes None None b Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:9774444 Yes 1a1, Direct HQ evidence Laura Campitelli Pratyush Das Yes $#ENSG00000118263#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019 $#ENSP00000309570#ENSG00000118263#ENST00000309446#C2H2 ZF Containing Proteins#$#ENSP00000387510#ENSG00000118263#ENST00000421199#C2H2 ZF Containing Proteins#$#ENSP00000398572#ENSG00000118263#ENST00000423015#C2H2 ZF Containing Proteins#$#ENSP00000393268#ENSG00000118263#ENST00000458272#C2H2 ZF Containing Proteins#$#ENSP00000403284#ENSG00000118263#ENST00000412414#C2H2 ZF Containing Proteins#$#ENSP00000413590#ENSG00000118263#ENST00000435602#C2H2 ZF Containing Proteins# FALSE 309 ENSG00000102349 KLF8 C2H2 ZF Yes Known motif Monomer or homomultimer 100 perc ID - in vitro None None IPR007087;IPR015880 11279 Kruppel like factor 8 [Source:HGNC Symbol;Acc:HGNC:6351] None DBD and Full Yes None None a Yes No No 1a1, Direct HQ evidence Laura Campitelli Jussi Taipale Yes None $#ENSP00000417303#ENSG00000102349#ENST00000468660#C2H2 ZF Containing Proteins#$#ENSP00000364063#ENSG00000102349#ENST00000374928#C2H2 ZF Containing Proteins# FALSE 310 ENSG00000119138 KLF9 C2H2 ZF Yes Known motif Monomer or homomultimer 100 perc ID - in vitro None None IPR007087;IPR015880 687 Kruppel like factor 9 [Source:HGNC Symbol;Acc:HGNC:1123] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:9858544;11751593 Yes 1a1, Direct HQ evidence Sam Lambert Laura Campitelli Yes $#ENSG00000119138#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:1356762, PMID:8051167 $#ENSP00000366330#ENSG00000119138#ENST00000377126#C2H2 ZF Containing Proteins# FALSE 311 ENSG00000185513 L3MBTL1 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Histone modifier; polycomb protein. IPR001660;IPR002515;IPR004092;IPR013761;IPR021129; 26013 L(3)mbt-like 1 (Drosophila) [Source:HGNC Symbol;Acc:HGNC:15905] None not tested not tested None None No Yes No No 5a, one of the source datasets predicts is as a TF Laura Campitelli Pratyush Das Yes $#ENSG00000185513#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002 $#ENSP00000362226#ENSG00000185513#ENST00000373134#C2H2 ZF Containing Proteins#MBT$#ENSP00000362227#ENSG00000185513#ENST00000373135#C2H2 ZF Containing Proteins#MBT$#ENSP00000398516#ENSG00000185513#ENST00000418998#C2H2 ZF Containing Proteins#MBT$#ENSP00000410139#ENSG00000185513#ENST00000422861#C2H2 ZF Containing Proteins#MBT, SAM_1 FALSE 312 ENSG00000198945 L3MBTL3 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Histone modifier; polycomb protein. IPR001660;IPR004092;IPR013761;IPR021129 84456 l(3)mbt-like 3 (Drosophila) [Source:HGNC Symbol;Acc:HGNC:23035] None not tested not tested None None No Yes No No 5a, one of the source datasets predicts is as a TF Pratyush Das Jussi Taipale No None $#ENSP00000437185#ENSG00000198945#ENST00000533560#C2H2 ZF Containing Proteins#Glyco_hydro_2_N, MBT, SAM_1, SAM_2 FALSE 313 ENSG00000154655 L3MBTL4 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Histone modifier; polycomb protein. IPR001660;IPR002515;IPR004092;IPR013761;IPR021129; 91133 l(3)mbt-like 4 (Drosophila) [Source:HGNC Symbol;Acc:HGNC:26677] None not tested not tested None None No Yes No Yes 4a, two or more datasets predict it as a TF Yimeng Yin Sam Lambert No $#ENSG00000154655#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002 $#ENSP00000382975#ENSG00000154655#ENST00000400104#C2H2 ZF Containing Proteins#MBT$#ENSP00000382976#ENSG00000154655#ENST00000400105#C2H2 ZF Containing Proteins#MBT, SAM_1, SAM_2$#ENSP00000462090#ENSG00000154655#ENST00000583809#C2H2 ZF Containing Proteins#MBT FALSE 314 ENSG00000103495 MAZ C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR007087;IPR015880 4150 MYC associated zinc finger protein [Source:HGNC Symbol;Acc:HGNC:6914] None DBD and Full not tested None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:1454839;15094381 No 1a1, Direct HQ evidence Arttu Jolma Sam Lambert Yes None $#ENSP00000219782#ENSG00000103495#ENST00000219782#C2H2 ZF Containing Proteins#$#ENSP00000313362#ENSG00000103495#ENST00000322945#C2H2 ZF Containing Proteins#$#ENSP00000443956#ENSG00000103495#ENST00000545521#C2H2 ZF Containing Proteins#$#ENSP00000460877#ENSG00000103495#ENST00000569978#C2H2 ZF Containing Proteins#$#ENSP00000460057#ENSG00000103495#ENST00000567444#C2H2 ZF Containing Proteins#zf-C2H2_jaz$#ENSP00000455473#ENSG00000103495#ENST00000568544#C2H2 ZF Containing Proteins#$#ENSP00000455726#ENSG00000103495#ENST00000562337#C2H2 ZF Containing Proteins#zf-C2H2_4, zf-RING_10$#ENSP00000461630#ENSG00000103495#ENST00000562557#C2H2 ZF Containing Proteins#$#ENSP00000455913#ENSG00000103495#ENST00000563012#C2H2 ZF Containing Proteins#$#ENSP00000455794#ENSG00000103495#ENST00000568411#C2H2 ZF Containing Proteins#zf-C2H2_jaz FALSE 315 ENSG00000085276 MECOM C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain None IPR001214;IPR007087;IPR015880; 2122 MDS1 and EVI1 complex locus [Source:HGNC Symbol;Acc:HGNC:3498] None not tested not tested None PMID: 8321231 SELEX model that is also in Jaspar, Direct b Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:15889140 Yes 2a1, Lower confidence direct evidence Jussi Taipale Yimeng Yin Yes $#ENSG00000085276#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:19767769 $#ENSP00000264674#ENSG00000085276#ENST00000264674#C2H2 ZF Containing Proteins#$#ENSP00000394302#ENSG00000085276#ENST00000433243#C2H2 ZF Containing Proteins#$#ENSP00000420466#ENSG00000085276#ENST00000460814#C2H2 ZF Containing Proteins#$#ENSP00000417922#ENSG00000085276#ENST00000460890#C2H2 ZF Containing Proteins#$#ENSP00000419770#ENSG00000085276#ENST00000464456#C2H2 ZF Containing Proteins#$#ENSP00000418689#ENSG00000085276#ENST00000466623#C2H2 ZF Containing Proteins#$#ENSP00000419757#ENSG00000085276#ENST00000487503#C2H2 ZF Containing Proteins#$#ENSP00000420072#ENSG00000085276#ENST00000494597#C2H2 ZF Containing Proteins#$#ENSP00000486104#ENSG00000085276#ENST00000628990#C2H2 ZF Containing Proteins#$#ENSP00000419995#ENSG00000085276#ENST00000468789#C2H2 ZF Containing Proteins# FALSE 316 ENSG00000188786 MTF1 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR007087;IPR015880 4520 metal-regulatory transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:7428] None DBD and Full Yes None PMID: 23012419 suggests that different types of metal ions function as allosteric modulators for this TF a Yes TF Gene_DNA-Binding: sequence-specific_Transactivation_PMIDS:7610056;16221973 Yes 1a1, Direct HQ evidence Arttu Jolma Pratyush Das Yes $#ENSG00000188786#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:9582278$#ENSG00000188786#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:3208749 $#ENSP00000362127#ENSG00000188786#ENST00000373036#C2H2 ZF Containing Proteins#Marek_A FALSE 317 ENSG00000085274 MYNN C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR000210;IPR007087;IPR011333;IPR013069;IPR015880; 55892 myoneurin [Source:HGNC Symbol;Acc:HGNC:14955] None Full not tested None None b Yes No Yes 1a1, Direct HQ evidence Pratyush Das Yimeng Yin Yes $#ENSG00000085274#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:10873615 $#ENSP00000326240#ENSG00000085274#ENST00000349841#C2H2 ZF Containing Proteins#BTB$#ENSP00000349150#ENSG00000085274#ENST00000356716#C2H2 ZF Containing Proteins#BTB$#ENSP00000440637#ENSG00000085274#ENST00000544106#C2H2 ZF Containing Proteins#BTB FALSE 318 ENSG00000196132 MYT1 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Crystal structure (PDB:2JX1) has GTGAACTTTCGGT DNA; similar to MYT1L SELEX and PBM sites. IPR002515;IPR013681 4661 myelin transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:7622] 2JX1 DBD and Full not tested None Crystal has GTGAACTTTCGGT DNA, similar to MYT1L SELEX and PBM sites a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:8980226 Yes 1a1, Direct HQ evidence Pratyush Das Arttu Jolma Yes $#ENSG00000196132#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:1280325 $#ENSP00000327465#ENSG00000196132#ENST00000328439#C2H2 ZF Containing Proteins#DUF812, MYT1$#ENSP00000353269#ENSG00000196132#ENST00000360149#C2H2 ZF Containing Proteins#MYT1$#ENSP00000442412#ENSG00000196132#ENST00000536311#C2H2 ZF Containing Proteins#DUF812, MYT1$#ENSP00000480510#ENSG00000196132#ENST00000622439#C2H2 ZF Containing Proteins#MYT1 FALSE 319 ENSG00000186487 MYT1L C2H2 ZF Yes Inferred motif Monomer or homomultimer High-throughput in vitro None None IPR002515;IPR013681 23040 myelin transcription factor 1 like [Source:HGNC Symbol;Acc:HGNC:7623] None DBD and Full not tested None None b Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:8631881;15935060 No 1a1, Direct HQ evidence Yimeng Yin Arttu Jolma Yes $#ENSG00000186487#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002 $#ENSP00000382114#ENSG00000186487#ENST00000399161#C2H2 ZF Containing Proteins#APG6, MYT1$#ENSP00000384219#ENSG00000186487#ENST00000407844#C2H2 ZF Containing Proteins#DUF342, DivIC$#ENSP00000396103#ENSG00000186487#ENST00000428368#C2H2 ZF Containing Proteins#APG6, MYT1$#ENSP00000382111#ENSG00000186487#ENST00000399157#C2H2 ZF Containing Proteins#APG6, ATG16, CALCOCO1, DUF342, DUF812, DivIC, FAM7 FALSE 320 ENSG00000099326 MZF1 C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source None None IPR003309;IPR007087;IPR008916;IPR015880 7593 myeloid zinc finger 1 [Source:HGNC Symbol;Acc:HGNC:13108] None not tested Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:7579328 Yes 1a1, Direct HQ evidence Laura Campitelli Sam Lambert Yes $#ENSG00000099326#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:7579328$#ENSG00000099326#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:7579328$#ENSG00000099326#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:1860835 $#ENSP00000215057#ENSG00000099326#ENST00000215057#C2H2 ZF Containing Proteins#SCAN$#ENSP00000472123#ENSG00000099326#ENST00000594108#C2H2 ZF Containing Proteins#SCAN$#ENSP00000469378#ENSG00000099326#ENST00000594234#C2H2 ZF Containing Proteins#SCAN$#ENSP00000469493#ENSG00000099326#ENST00000599369#C2H2 ZF Containing Proteins#SCAN$#ENSP00000472454#ENSG00000099326#ENST00000596039#C2H2 ZF Containing Proteins#SCAN FALSE 321 ENSG00000083635 NUFIP1 C2H2 ZF No ssDNA/RNA binding Not a DNA binding protein No motif Single C2H2 domain This is a known RNA-binding protein with a single C2H2 domain. TF-CAT considered it a candidate TF; but in the ten years since; no such evidence has emerged. IPR007087;IPR015880;IPR019496;IPR022755 26747 NUFIP1, FMR1 interacting protein 1 [Source:HGNC Symbol;Acc:HGNC:8057] None not tested not tested None None x Yes TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_Other_PMIDS:12941608;15107825 No 4a, two or more datasets predict it as a TF Pratyush Das Tim Hughes No None $#ENSP00000368459#ENSG00000083635#ENST00000379161#C2H2 ZF Containing Proteins#NUFIP1 FALSE 322 ENSG00000143867 OSR1 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR007087;IPR015880 130497 odd-skipped related transciption factor 1 [Source:HGNC Symbol;Acc:HGNC:8111] None DBD Yes None None b Yes No No 1a1, Direct HQ evidence Pratyush Das Arttu Jolma Yes None $#ENSP00000272223#ENSG00000143867#ENST00000272223#C2H2 ZF Containing Proteins# FALSE 323 ENSG00000164920 OSR2 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR007087;IPR015880 116039 odd-skipped related transciption factor 2 [Source:HGNC Symbol;Acc:HGNC:15830] None DBD and Full Yes None None b Yes No No 1a1, Direct HQ evidence Jussi Taipale Pratyush Das Yes $#ENSG00000164920#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IEA - GO_REF:0000019 $#ENSP00000297565#ENSG00000164920#ENST00000297565#C2H2 ZF Containing Proteins#$#ENSP00000402862#ENSG00000164920#ENST00000435298#C2H2 ZF Containing Proteins#$#ENSP00000430041#ENSG00000164920#ENST00000523368#C2H2 ZF Containing Proteins#$#ENSP00000414657#ENSG00000164920#ENST00000457907#C2H2 ZF Containing Proteins#$#ENSP00000430780#ENSG00000164920#ENST00000522510#C2H2 ZF Containing Proteins#$#ENSP00000429910#ENSG00000164920#ENST00000518199#C2H2 ZF Containing Proteins#$#ENSP00000430074#ENSG00000164920#ENST00000520951#C2H2 ZF Containing Proteins# FALSE 324 ENSG00000172818 OVOL1 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR007087;IPR015880 5017 ovo like transcriptional repressor 1 [Source:HGNC Symbol;Acc:HGNC:8525] None DBD and Full not tested None None b Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:17311813 Yes 1a1, Direct HQ evidence Sam Lambert Arttu Jolma Yes $#ENSG00000172818#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000172818#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019 $#ENSP00000337862#ENSG00000172818#ENST00000335987#C2H2 ZF Containing Proteins#$#ENSP00000434220#ENSG00000172818#ENST00000532448#C2H2 ZF Containing Proteins# FALSE 325 ENSG00000125850 OVOL2 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR007087;IPR015880 58495 ovo like zinc finger 2 [Source:HGNC Symbol;Acc:HGNC:15804] None DBD and Full not tested None None b Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:11983900;15225875 Yes 1a1, Direct HQ evidence Jussi Taipale Yimeng Yin Yes $#ENSG00000125850#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000125850#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IEA - GO_REF:0000019 $#ENSP00000278780#ENSG00000125850#ENST00000278780#C2H2 ZF Containing Proteins# FALSE 326 ENSG00000105261 OVOL3 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR007087;IPR015880 728361 ovo like zinc finger 3 [Source:HGNC Symbol;Acc:HGNC:14186] None not tested not tested None None c Yes No Yes 4a, two or more datasets predict it as a TF Jussi Taipale Yimeng Yin Yes $#ENSG00000105261#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000465620#ENSG00000105261#ENST00000585332#C2H2 ZF Containing Proteins#$#ENSP00000487603#ENSG00000105261#ENST00000633214#C2H2 ZF Containing Proteins# FALSE 327 ENSG00000198300 PEG3 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None SCAN C2H2 ZF Protein. IPR003309;IPR007087;IPR008916;IPR015880 5178 paternally expressed 3 [Source:HGNC Symbol;Acc:HGNC:8826] None Full not tested None None b Yes No Yes 4a, two or more datasets predict it as a TF Sam Lambert Arttu Jolma Yes $#ENSG00000198300#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000326581#ENSG00000198300#ENST00000326441#C2H2 ZF Containing Proteins#SCAN$#ENSP00000472402#ENSG00000198300#ENST00000593695#C2H2 ZF Containing Proteins#$#ENSP00000473190#ENSG00000198300#ENST00000598410#C2H2 ZF Containing Proteins#$#ENSP00000472395#ENSG00000198300#ENST00000599534#C2H2 ZF Containing Proteins#SCAN$#ENSP00000469486#ENSG00000198300#ENST00000599577#C2H2 ZF Containing Proteins#SCAN$#ENSP00000470467#ENSG00000198300#ENST00000600833#C2H2 ZF Containing Proteins#$#ENSP00000469144#ENSG00000198300#ENST00000594389#C2H2 ZF Containing Proteins# FALSE 328 ENSG00000181690 PLAG1 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR007087;IPR015880 5324 PLAG1 zinc finger [Source:HGNC Symbol;Acc:HGNC:9045] None DBD not tested None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:10646861 Yes 1a1, Direct HQ evidence Sam Lambert Arttu Jolma Yes $#ENSG00000181690#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:10646861$#ENSG00000181690#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:9722527 $#ENSP00000325546#ENSG00000181690#ENST00000316981#C2H2 ZF Containing Proteins#$#ENSP00000416537#ENSG00000181690#ENST00000429357#C2H2 ZF Containing Proteins#$#ENSP00000404067#ENSG00000181690#ENST00000423799#C2H2 ZF Containing Proteins# FALSE 329 ENSG00000118495 PLAGL1 C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain None IPR007087;IPR015880 5325 PLAG1 like zinc finger 1 [Source:HGNC Symbol;Acc:HGNC:9046] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:9671765;9722527 Yes 1a1, Direct HQ evidence Tim Hughes Jussi Taipale Yes $#ENSG00000118495#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IDA - PMID:9671765 $#ENSP00000346810#ENSG00000118495#ENST00000354765#C2H2 ZF Containing Proteins#zf-C2H2_4$#ENSP00000356543#ENSG00000118495#ENST00000367571#C2H2 ZF Containing Proteins#zf-C2H2_4$#ENSP00000356544#ENSG00000118495#ENST00000367572#C2H2 ZF Containing Proteins#zf-C2H2_4$#ENSP00000376124#ENSG00000118495#ENST00000392307#C2H2 ZF Containing Proteins#$#ENSP00000400060#ENSG00000118495#ENST00000416623#C2H2 ZF Containing Proteins#zf-C2H2_4$#ENSP00000395960#ENSG00000118495#ENST00000417959#C2H2 ZF Containing Proteins#zf-C2H2_4$#ENSP00000392418#ENSG00000118495#ENST00000437412#C2H2 ZF Containing Proteins#zf-C2H2_4$#ENSP00000400929#ENSG00000118495#ENST00000444202#C2H2 ZF Containing Proteins#zf-C2H2_4$#ENSP00000487447#ENSG00000118495#ENST00000626294#C2H2 ZF Containing Proteins#$#ENSP00000486711#ENSG00000118495#ENST00000626373#C2H2 ZF Containing Proteins#$#ENSP00000486763#ENSG00000118495#ENST00000629195#C2H2 ZF Containing Proteins#$#ENSP00000486355#ENSG00000118495#ENST00000625622#C2H2 ZF Containing Proteins#zf-C2H2_4 FALSE 330 ENSG00000126003 PLAGL2 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR007087;IPR015880 5326 PLAG1 like zinc finger 2 [Source:HGNC Symbol;Acc:HGNC:9047] None DBD and Full Yes None None a Yes TF Gene Candidate__Transactivation_PMIDS:9722527 Yes 1a1, Direct HQ evidence Pratyush Das Yimeng Yin Yes $#ENSG00000126003#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:15361364$#ENSG00000126003#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:9722527 $#ENSP00000246229#ENSG00000126003#ENST00000246229#C2H2 ZF Containing Proteins# FALSE 331 ENSG00000057657 PRDM1 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001214;IPR007087;IPR015880;IPR016608 639 PR domain 1 [Source:HGNC Symbol;Acc:HGNC:9346] None DBD and Full not tested None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:1851123 Yes 1a1, Direct HQ evidence Pratyush Das Tim Hughes Yes $#ENSG00000057657#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:1851123$#ENSG00000057657#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:1851123 $#ENSP00000358085#ENSG00000057657#ENST00000369089#C2H2 ZF Containing Proteins#SET$#ENSP00000358087#ENSG00000057657#ENST00000369091#C2H2 ZF Containing Proteins#SET$#ENSP00000358092#ENSG00000057657#ENST00000369096#C2H2 ZF Containing Proteins#SET$#ENSP00000399772#ENSG00000057657#ENST00000450060#C2H2 ZF Containing Proteins#SET FALSE 332 ENSG00000170325 PRDM10 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif Has a putative AT-hook None IPR001214;IPR007087;IPR015880;IPR022755 56980 PR domain 10 [Source:HGNC Symbol;Acc:HGNC:13995] None Full not tested None None b Yes No No 4a, two or more datasets predict it as a TF Yimeng Yin Arttu Jolma Yes None $#ENSP00000302669#ENSG00000170325#ENST00000304538#C2H2 ZF Containing Proteins#Tristanin_u2$#ENSP00000351686#ENSG00000170325#ENST00000358825#C2H2 ZF Containing Proteins#Tristanin_u2$#ENSP00000354118#ENSG00000170325#ENST00000360871#C2H2 ZF Containing Proteins#Tristanin_u2$#ENSP00000398431#ENSG00000170325#ENST00000423662#C2H2 ZF Containing Proteins#Tristanin_u2$#ENSP00000432237#ENSG00000170325#ENST00000526082#C2H2 ZF Containing Proteins#Tristanin_u2$#ENSP00000435940#ENSG00000170325#ENST00000533431#C2H2 ZF Containing Proteins#Tristanin_u2$#ENSP00000432093#ENSG00000170325#ENST00000527581#C2H2 ZF Containing Proteins# FALSE 333 ENSG00000130711 PRDM12 C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain None IPR001214;IPR007087;IPR015880;IPR017126 59335 PR domain 12 [Source:HGNC Symbol;Acc:HGNC:13997] None DBD not tested None None b Yes No No 2a1, Lower confidence direct evidence Pratyush Das Laura Campitelli No None $#ENSP00000253008#ENSG00000130711#ENST00000253008#C2H2 ZF Containing Proteins#SET FALSE 334 ENSG00000112238 PRDM13 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR001214;IPR007087;IPR015880; 59336 PR domain 13 [Source:HGNC Symbol;Acc:HGNC:13998] None not tested not tested None None b Yes No No 4a, two or more datasets predict it as a TF Sam Lambert Laura Campitelli Yes None $#ENSP00000358217#ENSG00000112238#ENST00000369215#C2H2 ZF Containing Proteins#SET FALSE 335 ENSG00000147596 PRDM14 C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source None None IPR001214;IPR007087;IPR015880; 63978 PR domain 14 [Source:HGNC Symbol;Acc:HGNC:14001] None Full not tested None None b Yes No No 2a2, orthologous lower confidence evidence Sam Lambert Arttu Jolma Yes None $#ENSP00000276594#ENSG00000147596#ENST00000276594#C2H2 ZF Containing Proteins#SET$#ENSP00000408653#ENSG00000147596#ENST00000426346#C2H2 ZF Containing Proteins# FALSE 336 ENSG00000141956 PRDM15 C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain None IPR001214;IPR007087;IPR015880; 63977 PR domain 15 [Source:HGNC Symbol;Acc:HGNC:13999] None DBD and Full not tested None None b Yes No Yes 2a1, Lower confidence direct evidence Laura Campitelli Pratyush Das Yes $#ENSG00000141956#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000269844#ENSG00000141956#ENST00000269844#C2H2 ZF Containing Proteins#SET, zf-C2H2_4, zf-C2H2_6$#ENSP00000381556#ENSG00000141956#ENST00000398548#C2H2 ZF Containing Proteins#SET, zf-C2H2_4, zf-C2H2_6, zf-C2H2_jaz$#ENSP00000408592#ENSG00000141956#ENST00000422911#C2H2 ZF Containing Proteins#SET, zf-C2H2_4, zf-C2H2_6, zf-C2H2_jaz$#ENSP00000390245#ENSG00000141956#ENST00000447207#C2H2 ZF Containing Proteins#SET, zf-C2H2_4, zf-C2H2_6, zf-C2H2_jaz FALSE 337 ENSG00000142611 PRDM16 C2H2 ZF Yes Inferred motif Monomer or homomultimer In vivo/Misc source None None IPR001214;IPR007087;IPR015880; 63976 PR domain 16 [Source:HGNC Symbol;Acc:HGNC:14000] None not tested not tested None None b Yes No No 2a2, orthologous lower confidence evidence Laura Campitelli Sam Lambert Yes None $#ENSP00000270722#ENSG00000142611#ENST00000270722#C2H2 ZF Containing Proteins#SET$#ENSP00000367643#ENSG00000142611#ENST00000378391#C2H2 ZF Containing Proteins#SET FALSE 338 ENSG00000116731 PRDM2 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Has been suggested to function as a histone methyltransferase (PMID: 15282304), but it has a decent set of C2H2 ZF domains and could thus bind DNA independently. IPR001214;IPR007087;IPR009170;IPR015880 7799 PR domain 2 [Source:HGNC Symbol;Acc:HGNC:9347] None not tested not tested None None a Yes No Yes 4a, two or more datasets predict it as a TF Yimeng Yin Arttu Jolma Yes $#ENSG00000116731#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:7590293, PMID:8654390 $#ENSP00000235372#ENSG00000116731#ENST00000235372#C2H2 ZF Containing Proteins#SET$#ENSP00000341621#ENSG00000116731#ENST00000343137#C2H2 ZF Containing Proteins#$#ENSP00000411103#ENSG00000116731#ENST00000413440#C2H2 ZF Containing Proteins#$#ENSP00000425028#ENSG00000116731#ENST00000503842#C2H2 ZF Containing Proteins#$#ENSP00000426737#ENSG00000116731#ENST00000505823#C2H2 ZF Containing Proteins#$#ENSP00000365216#ENSG00000116731#ENST00000376048#C2H2 ZF Containing Proteins#SET$#ENSP00000474273#ENSG00000116731#ENST00000487453#C2H2 ZF Containing Proteins# FALSE 339 ENSG00000110851 PRDM4 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001214;IPR007087;IPR015880;IPR017124 11108 PR domain 4 [Source:HGNC Symbol;Acc:HGNC:9348] None DBD and Full not tested None None a Yes No No 1a1, Direct HQ evidence Pratyush Das Yimeng Yin Yes None $#ENSP00000228437#ENSG00000110851#ENST00000228437#C2H2 ZF Containing Proteins#zf-C2H2_jaz, zf-met$#ENSP00000448684#ENSG00000110851#ENST00000547188#C2H2 ZF Containing Proteins#$#ENSP00000449295#ENSG00000110851#ENST00000550659#C2H2 ZF Containing Proteins# FALSE 340 ENSG00000138738 PRDM5 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Has a nice cassette of C2H2 ZF domains. Moreover, (PMID: 17636019) has performed SELEX for it and validated the result. IPR001214;IPR007087;IPR015880;IPR017125;IPR022755; 11107 PR domain 5 [Source:HGNC Symbol;Acc:HGNC:9349] None Full not tested None None a Yes No Yes 4a, two or more datasets predict it as a TF Yimeng Yin Arttu Jolma Yes $#ENSG00000138738#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:17636019 $#ENSP00000264808#ENSG00000138738#ENST00000264808#C2H2 ZF Containing Proteins#$#ENSP00000377955#ENSG00000138738#ENST00000394435#C2H2 ZF Containing Proteins#$#ENSP00000404832#ENSG00000138738#ENST00000428209#C2H2 ZF Containing Proteins#$#ENSP00000422309#ENSG00000138738#ENST00000515109#C2H2 ZF Containing Proteins# FALSE 341 ENSG00000061455 PRDM6 C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect None IPR001214;IPR007087;IPR015880; 93166 PR domain 6 [Source:HGNC Symbol;Acc:HGNC:9350] None DBD not tested None None b Yes No No 1a1, Direct HQ evidence Jussi Taipale Pratyush Das Yes None $#ENSP00000384725#ENSG00000061455#ENST00000407847#C2H2 ZF Containing Proteins#SET FALSE 342 ENSG00000152784 PRDM8 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR001214;IPR007087;IPR015880; 56978 PR domain 8 [Source:HGNC Symbol;Acc:HGNC:13993] None Full not tested None None b Yes No No 4a, two or more datasets predict it as a TF Jussi Taipale Arttu Jolma Yes None $#ENSP00000339764#ENSG00000152784#ENST00000339711#C2H2 ZF Containing Proteins#SET, zf-H2C2_2$#ENSP00000406998#ENSG00000152784#ENST00000415738#C2H2 ZF Containing Proteins#SET, zf-H2C2_2$#ENSP00000425149#ENSG00000152784#ENST00000515013#C2H2 ZF Containing Proteins#SET$#ENSP00000423985#ENSG00000152784#ENST00000504452#C2H2 ZF Containing Proteins#SET, zf-H2C2_2 FALSE 343 ENSG00000164256 PRDM9 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001214;IPR001909;IPR003655;IPR007087;IPR015880;IPR019041 56979 PR domain 9 [Source:HGNC Symbol;Acc:HGNC:13994] 5EGB not tested not tested None Structure is fine b Yes No No 1a1, Direct HQ evidence Laura Campitelli Yimeng Yin Yes None $#ENSP00000296682#ENSG00000164256#ENST00000296682#C2H2 ZF Containing Proteins#KRAB, SET, SSXRD, zf-C2H2_4$#ENSP00000425471#ENSG00000164256#ENST00000502755#C2H2 ZF Containing Proteins#KRAB, Phage_F$#ENSP00000489227#ENSG00000164256#ENST00000635252#C2H2 ZF Containing Proteins#SET, SSXRD TRUE 344 ENSG00000185238 PRMT3 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif Single C2H2 domain Has a single C2H2 ZF (PMID: 10931850). IPR007087;IPR025799;IPR029063; 10196 Protein arginine methyltransferase 3 [Source:HGNC Symbol;Acc:HGNC:30163] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Yimeng Yin Jussi Taipale No None $#ENSP00000331879#ENSG00000185238#ENST00000331079#Other#FtsJ, MTS, Met_10, Methyltransf_11, Methyltransf_1$#ENSP00000397766#ENSG00000185238#ENST00000437750#Other#FtsJ, MTS, Met_10, Methyltransf_11, Methyltransf_1 FALSE 345 ENSG00000146587 RBAK C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 57786 RB associated KRAB zinc finger [Source:HGNC Symbol;Acc:HGNC:17680] None DBD and Full not tested None None a Yes TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_Co-activation_PMIDS:14664718 No 1a1, Direct HQ evidence Sam Lambert Arttu Jolma Yes None $#ENSP00000380120#ENSG00000146587#ENST00000396912#C2H2 ZF Containing Proteins#KRAB, Zn-ribbon_8, zf-C2H2_6, zinc_ribbon_15$#ENSP00000275423#ENSG00000146587#ENST00000353796#C2H2 ZF Containing Proteins#KRAB, Zn-ribbon_8, zf-C2H2_6, zinc_ribbon_15 TRUE 346 ENSG00000131381 RBSN C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif Single C2H2 domain Potential false positive - protein functions in membrane trafficking. IPR000306;IPR007087;IPR011011;IPR017455;IPR021565; 64145 rabenosyn, RAB effector [Source:HGNC Symbol;Acc:HGNC:20759] None Full not tested None None x No No No 5a, one of the source datasets predicts is as a TF Pratyush Das Arttu Jolma No None $#ENSP00000253699#ENSG00000131381#ENST00000253699#C2H2 ZF Containing Proteins#FYVE, NPF, Rbsn$#ENSP00000387724#ENSG00000131381#ENST00000449050#C2H2 ZF Containing Proteins#zf-Di19$#ENSP00000422551#ENSG00000131381#ENST00000476527#C2H2 ZF Containing Proteins#FYVE, NPF, Rbsn$#ENSP00000427038#ENSG00000131381#ENST00000507357#C2H2 ZF Containing Proteins#zf-AD, zf-Di19 FALSE 347 ENSG00000214022 REPIN1 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Binds DNA specifically based on EMSA and nuclease footprinting (PMID: 10606657). IPR007087;IPR015880 29803 replication initiator 1 [Source:HGNC Symbol;Acc:HGNC:17922] None not tested not tested None None x Yes No No 4a, two or more datasets predict it as a TF Arttu Jolma Jussi Taipale No None $#ENSP00000407714#ENSG00000214022#ENST00000444957#C2H2 ZF Containing Proteins#$#ENSP00000418507#ENSG00000214022#ENST00000466559#C2H2 ZF Containing Proteins#$#ENSP00000380451#ENSG00000214022#ENST00000397281#C2H2 ZF Containing Proteins#$#ENSP00000420578#ENSG00000214022#ENST00000479668#C2H2 ZF Containing Proteins#$#ENSP00000417982#ENSG00000214022#ENST00000482680#C2H2 ZF Containing Proteins#$#ENSP00000417291#ENSG00000214022#ENST00000489432#C2H2 ZF Containing Proteins#$#ENSP00000428129#ENSG00000214022#ENST00000518514#C2H2 ZF Containing Proteins#$#ENSP00000388287#ENSG00000214022#ENST00000425389#C2H2 ZF Containing Proteins# FALSE 348 ENSG00000084093 REST C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source None None IPR007087;IPR015880 5978 RE1 silencing transcription factor [Source:HGNC Symbol;Acc:HGNC:9966] None Full Yes None Jaspar ChIP-seq model has a robust and specific signal a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:15240883 Yes 2a1, Lower confidence direct evidence Tim Hughes Jussi Taipale Yes $#ENSG00000084093#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:10449787, PMID:10734093, PMID:21284946$#ENSG00000084093#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IEA - GO_REF:0000019$#ENSG00000084093#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:19342457 $#ENSP00000311816#ENSG00000084093#ENST00000309042#C2H2 ZF Containing Proteins#zf-C2H2_4, zf-H2C2_5$#ENSP00000479151#ENSG00000084093#ENST00000611211#C2H2 ZF Containing Proteins#$#ENSP00000484836#ENSG00000084093#ENST00000619101#C2H2 ZF Containing Proteins#zf-C2H2_4, zf-H2C2_5$#ENSP00000481650#ENSG00000084093#ENST00000622863#C2H2 ZF Containing Proteins# FALSE 349 ENSG00000117000 RLF C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR007087;IPR015880 6018 rearranged L-myc fusion [Source:HGNC Symbol;Acc:HGNC:10025] None Full Yes None None b Yes No No 4a, two or more datasets predict it as a TF Yimeng Yin Pratyush Das Yes None $#ENSP00000361857#ENSG00000117000#ENST00000372771#C2H2 ZF Containing Proteins#zf-C2H2_4 FALSE 350 ENSG00000124782 RREB1 C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source None None IPR007087;IPR015880 6239 ras responsive element binding protein 1 [Source:HGNC Symbol;Acc:HGNC:10449] None Full not tested None SELEX model looks like an nonspecific or artifact a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:8816445 Yes 2a1, Lower confidence direct evidence Sam Lambert Laura Campitelli Yes $#ENSG00000124782#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000335574#ENSG00000124782#ENST00000334984#C2H2 ZF Containing Proteins#zf-C2H2_4$#ENSP00000305560#ENSG00000124782#ENST00000349384#C2H2 ZF Containing Proteins#zf-C2H2_4$#ENSP00000369265#ENSG00000124782#ENST00000379933#C2H2 ZF Containing Proteins#zf-C2H2_4$#ENSP00000369270#ENSG00000124782#ENST00000379938#C2H2 ZF Containing Proteins#zf-C2H2_4$#ENSP00000419511#ENSG00000124782#ENST00000483150#C2H2 ZF Containing Proteins#zf-C2H2_4, zf-met FALSE 351 ENSG00000103449 SALL1 C2H2 ZF Yes Inferred motif Monomer or homomultimer In vivo/Misc source None None IPR007087;IPR015880 6299 spalt like transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:10524] None DBD not tested None None a Yes TF Gene_Transcription Regulatory Activity: heterochromatin interaction/binding_Other; TF PPI_PMIDS:11836251 Yes 2a2, orthologous lower confidence evidence Yimeng Yin Jussi Taipale Yes $#ENSG00000103449#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 | NAS - PMID:9425907 $#ENSP00000251020#ENSG00000103449#ENST00000251020#C2H2 ZF Containing Proteins#IZUMO, zf-C2H2_2, zf-C2H2_4, zf-C2H2_jaz, zf-met$#ENSP00000455582#ENSG00000103449#ENST00000566102#C2H2 ZF Containing Proteins#$#ENSP00000407914#ENSG00000103449#ENST00000440970#C2H2 ZF Containing Proteins#IZUMO, zf-C2H2_2, zf-C2H2_4, zf-C2H2_jaz, zf-met$#ENSP00000456777#ENSG00000103449#ENST00000570206#C2H2 ZF Containing Proteins#IZUMO, zf-C2H2_2, zf-C2H2_4, zf-C2H2_jaz, zf-met FALSE 352 ENSG00000165821 SALL2 C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain None IPR007087;IPR015880 6297 Spalt like transcription factor 2 [Source:HGNC Symbol;Acc:HGNC:10526 None Full Yes None None a Yes No No 2a1, Lower confidence direct evidence Yimeng Yin Pratyush Das Yes $#ENSG00000165821#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000484460#ENSG00000165821#ENST00000611430#C2H2 ZF Containing Proteins#$#ENSP00000483562#ENSG00000165821#ENST00000614342#C2H2 ZF Containing Proteins#zf-C2H2_2, zf-C2H2_4, zf-Di19$#ENSP00000396773#ENSG00000165821#ENST00000450879#C2H2 ZF Containing Proteins#zf-C2H2_4$#ENSP00000438493#ENSG00000165821#ENST00000537235#C2H2 ZF Containing Proteins#DUF2076$#ENSP00000439654#ENSG00000165821#ENST00000541965#C2H2 ZF Containing Proteins#DUF2076$#ENSP00000440054#ENSG00000165821#ENST00000546363#C2H2 ZF Containing Proteins#zf-C2H2_4$#ENSP00000483202#ENSG00000165821#ENST00000613414#C2H2 ZF Containing Proteins# FALSE 353 ENSG00000256463 SALL3 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR007087;IPR015880 27164 spalt like transcription factor 3 [Source:HGNC Symbol;Acc:HGNC:10527] None not tested not tested None None b Yes No No 2a2, orthologous lower confidence evidence Pratyush Das Sam Lambert Yes $#ENSG00000256463#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $##ENSG00000256463##C2H2 ZF Containing Proteins# FALSE 354 ENSG00000101115 SALL4 C2H2 ZF Yes Inferred motif Monomer or homomultimer In vivo/Misc source None None IPR007087;IPR015880 57167 spalt like transcription factor 4 [Source:HGNC Symbol;Acc:HGNC:15924] None Full not tested None None b Yes TF Gene_DNA-Binding: non-sequence-specific; Transcription Factor Binding: tf co-factor binding; Transcription Regulatory Activity: heterochromatin interaction/binding_Co-activation_PMIDS:16380715;1684 Yes 2a2, orthologous lower confidence evidence Yimeng Yin Tim Hughes Yes $#ENSG00000101115#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000217086#ENSG00000101115#ENST00000217086#C2H2 ZF Containing Proteins#NinF$#ENSP00000360594#ENSG00000101115#ENST00000371539#C2H2 ZF Containing Proteins#$#ENSP00000379319#ENSG00000101115#ENST00000395997#C2H2 ZF Containing Proteins#NinF FALSE 355 ENSG00000261678 SCRT1 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR007087;IPR015880 83482 Scratch family transcriptional repressor 1 [Source:HGNC Symbol;Acc:HGNC:15950] None DBD not tested None None a Yes No No 1a1, Direct HQ evidence Sam Lambert Jussi Taipale Yes $#ENSG00000261678#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:11274425 $#ENSP00000455711#ENSG00000261678#ENST00000569446#C2H2 ZF Containing Proteins# FALSE 356 ENSG00000215397 SCRT2 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR007087;IPR015880 85508 scratch family transcriptional repressor 2 [Source:HGNC Symbol;Acc:HGNC:15952] None DBD not tested None None b Yes No Yes 1a1, Direct HQ evidence Laura Campitelli Arttu Jolma Yes $#ENSG00000215397#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IC - PMID:21252910 $#ENSP00000246104#ENSG00000215397#ENST00000246104#C2H2 ZF Containing Proteins# FALSE 357 ENSG00000125520 SLC2A4RG C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif Single C2H2 domain Two papers demonstrate a bit of evidence for DNA binding (PMID:10825161 and PMID: 14625278 ). IPR007087;IPR015880 56731 SLC2A4 regulator [Source:HGNC Symbol;Acc:HGNC:15930] None Full not tested None None x Yes No Yes 4a, two or more datasets predict it as a TF Tim Hughes Sam Lambert No $#ENSG00000125520#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:10825161 $#ENSP00000266077#ENSG00000125520#ENST00000266077#C2H2 ZF Containing Proteins# FALSE 358 ENSG00000124216 SNAI1 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR007087;IPR015880 6615 snail family transcriptional repressor 1 [Source:HGNC Symbol;Acc:HGNC:11128] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:12917416;14673164;12917416;16158046;16801545;17359298 Yes 1a1, Direct HQ evidence Pratyush Das Laura Campitelli Yes $#ENSG00000124216#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:11912130 $#ENSP00000244050#ENSG00000124216#ENST00000244050#C2H2 ZF Containing Proteins# FALSE 359 ENSG00000019549 SNAI2 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR007087;IPR015880 6591 snail family transcriptional repressor 2 [Source:HGNC Symbol;Acc:HGNC:11094] None DBD and Full not tested None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:10518215;16286009 Yes 1a1, Direct HQ evidence Jussi Taipale Sam Lambert Yes $#ENSG00000019549#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:10866665, PMID:11912130, PMID:16707493,$#ENSG00000019549#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019 $#ENSP00000020945#ENSG00000019549#ENST00000020945#C2H2 ZF Containing Proteins#$#ENSP00000380034#ENSG00000019549#ENST00000396822#C2H2 ZF Containing Proteins# FALSE 360 ENSG00000185669 SNAI3 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR002355;IPR007087;IPR015880; 333929 snail family transcriptional repressor 3 [Source:HGNC Symbol;Acc:HGNC:18411] None Full not tested None None b Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:10606664 Yes 1a1, Direct HQ evidence Yimeng Yin Laura Campitelli Yes $#ENSG00000185669#GO:0000982#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000185669#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IEA - GO_REF:0000019 $#ENSP00000327968#ENSG00000185669#ENST00000332281#C2H2 ZF Containing Proteins# FALSE 361 ENSG00000185591 SP1 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR007087;IPR015880 6667 Sp1 transcription factor [Source:HGNC Symbol;Acc:HGNC:11205] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:15282343;15589828 Yes 1a1, Direct HQ evidence Laura Campitelli Arttu Jolma Yes $#ENSG00000185591#GO:0000982#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:21659522$#ENSG00000185591#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:12169688, PMID:12560508 $#ENSP00000329357#ENSG00000185591#ENST00000327443#C2H2 ZF Containing Proteins#$#ENSP00000404263#ENSG00000185591#ENST00000426431#C2H2 ZF Containing Proteins#$#ENSP00000458133#ENSG00000185591#ENST00000548560#C2H2 ZF Containing Proteins#$#ENSP00000457804#ENSG00000185591#ENST00000551969#C2H2 ZF Containing Proteins# FALSE 362 ENSG00000167182 SP2 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR007087;IPR015880 6668 Sp2 transcription factor [Source:HGNC Symbol;Acc:HGNC:11207] None DBD and Full not tested None None a Yes No Yes 1a1, Direct HQ evidence Sam Lambert Arttu Jolma Yes $#ENSG00000167182#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000365931#ENSG00000167182#ENST00000376741#C2H2 ZF Containing Proteins#$#ENSP00000489736#ENSG00000167182#ENST00000635868#C2H2 ZF Containing Proteins#$#ENSP00000490512#ENSG00000167182#ENST00000637314#C2H2 ZF Containing Proteins#$#ENSP00000490351#ENSG00000167182#ENST00000637943#C2H2 ZF Containing Proteins# FALSE 363 ENSG00000172845 SP3 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR007087;IPR015880 6670 Sp3 transcription factor [Source:HGNC Symbol;Acc:HGNC:11208] None DBD and Full not tested None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:12591615 Yes 1a1, Direct HQ evidence Sam Lambert Arttu Jolma Yes $#ENSG00000172845#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000172845#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019 $#ENSP00000310301#ENSG00000172845#ENST00000310015#C2H2 ZF Containing Proteins#$#ENSP00000413665#ENSG00000172845#ENST00000416195#C2H2 ZF Containing Proteins#$#ENSP00000406140#ENSG00000172845#ENST00000418194#C2H2 ZF Containing Proteins# FALSE 364 ENSG00000105866 SP4 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR007087;IPR015880 6671 Sp4 transcription factor [Source:HGNC Symbol;Acc:HGNC:11209] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:15265862 Yes 1a1, Direct HQ evidence Jussi Taipale Pratyush Das Yes $#ENSG00000105866#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000222584#ENSG00000105866#ENST00000222584#C2H2 ZF Containing Proteins#$#ENSP00000393623#ENSG00000105866#ENST00000432066#C2H2 ZF Containing Proteins# FALSE 365 ENSG00000204335 SP5 C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain Transfac motif has some similarity to known Sp1 TF motifs from multiple species and sources IPR007087;IPR015880 389058 Sp5 transcription factor [Source:HGNC Symbol;Acc:HGNC:14529] None DBD not tested None None a Yes No No 2a1, Lower confidence direct evidence Laura Campitelli Sam Lambert Yes None $#ENSP00000364430#ENSG00000204335#ENST00000375281#C2H2 ZF Containing Proteins# FALSE 366 ENSG00000189120 SP6 C2H2 ZF Yes Inferred motif Monomer or homomultimer High-throughput in vitro None None IPR007087;IPR015880 80320 Sp6 transcription factor [Source:HGNC Symbol;Acc:HGNC:14530] None DBD and Full Yes None None a Yes Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0 No 1a2, Orthologous HQ evidence Sam Lambert Laura Campitelli Yes None $#ENSP00000340799#ENSG00000189120#ENST00000342234#C2H2 ZF Containing Proteins#$#ENSP00000438209#ENSG00000189120#ENST00000536300#C2H2 ZF Containing Proteins# FALSE 367 ENSG00000170374 SP7 C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain None IPR007087;IPR015880 121340 Sp7 transcription factor [Source:HGNC Symbol;Acc:HGNC:17321] None DBD not tested None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; TF PPI; Transactivation_PMIDS:16041384 No 2a1, Lower confidence direct evidence Jussi Taipale Arttu Jolma Yes None $#ENSP00000302812#ENSG00000170374#ENST00000303846#C2H2 ZF Containing Proteins#$#ENSP00000441367#ENSG00000170374#ENST00000537210#C2H2 ZF Containing Proteins#$#ENSP00000443827#ENSG00000170374#ENST00000536324#C2H2 ZF Containing Proteins#$#ENSP00000449355#ENSG00000170374#ENST00000547755#C2H2 ZF Containing Proteins# FALSE 368 ENSG00000164651 SP8 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR007087;IPR015880 221833 Sp8 transcription factor [Source:HGNC Symbol;Acc:HGNC:19196] None DBD and Full not tested None None b Yes Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0 No 1a1, Direct HQ evidence Sam Lambert Yimeng Yin Yes None $#ENSP00000354482#ENSG00000164651#ENST00000361443#C2H2 ZF Containing Proteins#$#ENSP00000408792#ENSG00000164651#ENST00000418710#C2H2 ZF Containing Proteins#$#ENSP00000483588#ENSG00000164651#ENST00000617581#C2H2 ZF Containing Proteins# FALSE 369 ENSG00000217236 SP9 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR007087;IPR015880 100131390 Sp9 transcription factor [Source:HGNC Symbol;Acc:HGNC:30690] None DBD not tested None None a Yes No No 1a1, Direct HQ evidence Sam Lambert Arttu Jolma Yes None $#ENSP00000378418#ENSG00000217236#ENST00000394967#C2H2 ZF Containing Proteins# FALSE 370 ENSG00000147488 ST18 C2H2 ZF Yes Inferred motif Monomer or homomultimer High-throughput in vitro None None IPR002515;IPR013681 9705 ST18, C2H2C-type zinc finger [Source:HGNC Symbol;Acc:HGNC:18695] None DBD and Full not tested None None a Yes No Yes 1a2, Orthologous HQ evidence Pratyush Das Sam Lambert Yes $#ENSG00000147488#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002 $#ENSP00000276480#ENSG00000147488#ENST00000276480#C2H2 ZF Containing Proteins#DUF812, MYT1$#ENSP00000428521#ENSG00000147488#ENST00000517580#C2H2 ZF Containing Proteins#MYT1$#ENSP00000428096#ENSG00000147488#ENST00000519118#C2H2 ZF Containing Proteins# FALSE 371 ENSG00000135148 TRAFD1 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif Single C2H2 domain Possible false positive: the protein negatively regulates IRF3 and NFKB but there is no evidence for DNA-binding and it is likely to operate upstream on the signalling cascade (PMID:18849341). None 10906 TRAF-type zinc finger domain containing 1 [Source:HGNC Symbol;Acc:HGNC:24808] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Matt Weirauch Arttu Jolma No None $#ENSP00000396526#ENSG00000135148#ENST00000412615#Other#$#ENSP00000257604#ENSG00000135148#ENST00000257604#Other#$#ENSP00000473800#ENSG00000135148#ENST00000548092#Other#zf-TRAF$#ENSP00000450357#ENSG00000135148#ENST00000552896#Other# FALSE 372 ENSG00000179981 TSHZ1 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR001356;IPR007087;IPR015880; 10194 teashirt zinc finger homeobox 1 [Source:HGNC Symbol;Acc:HGNC:10669] None DBD not tested None PMID:25918232 Seems like a proper homeodomain with roles in olfactory bulb PMID:24487590 and pancreatic _-Cell maturation b Yes No Yes 3a, decent circumstantial evidence for its role as Sam Lambert Pratyush Das Yes $#ENSG00000179981#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IBA - GO_REF:0000033 $#ENSP00000323584#ENSG00000179981#ENST00000322038#C2H2 ZF Containing Proteins#zf-C2H2_2, zf-C2HE$#ENSP00000464391#ENSG00000179981#ENST00000580243#C2H2 ZF Containing Proteins#zf-C2H2_2, zf-C2HE$#ENSP00000452718#ENSG00000179981#ENST00000560661#C2H2 ZF Containing Proteins#$#ENSP00000453834#ENSG00000179981#ENST00000560918#C2H2 ZF Containing Proteins# FALSE 373 ENSG00000182463 TSHZ2 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Also contains an atypical homodomain (Uniprot) not identified by Pfam. IPR001356;IPR007087;IPR015880; 128553 teashirt zinc finger homeobox 2 [Source:HGNC Symbol;Acc:HGNC:13010] None DBD not tested None PMID:24487590;PMID:25918232; Homolog to TSHZ1 that seems like a proper homeodomain with roles in olfactory bulb PMID:24487590 pancreatic _-Cell maturation PMID:25918232 b Yes No Yes 3a, decent circumstantial evidence for its role as Pratyush Das Sam Lambert Yes $#ENSG00000182463#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IBA - GO_REF:0000033 $#ENSP00000360552#ENSG00000182463#ENST00000371497#C2H2 ZF Containing Proteins#zf-C2H2_2, zf-C2H2_4, zf-met$#ENSP00000333114#ENSG00000182463#ENST00000329613#C2H2 ZF Containing Proteins#zf-C2H2_2, zf-C2H2_4, zf-met$#ENSP00000475114#ENSG00000182463#ENST00000603338#C2H2 ZF Containing Proteins#zf-C2H2_2, zf-C2H2_4, zf-met$#ENSP00000487408#ENSG00000182463#ENST00000626626#C2H2 ZF Containing Proteins# FALSE 374 ENSG00000121297 TSHZ3 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None The C2H2 domains are too spread out to be credible; but there is also a homodomain. Seems more likely than not that it binds DNA. IPR001356;IPR007087;IPR015880; 57616 teashirt zinc finger homeobox 3 [Source:HGNC Symbol;Acc:HGNC:30700] None DBD and Full not tested None None a Yes No Yes 4a, two or more datasets predict it as a TF Arttu Jolma Tim Hughes Yes $#ENSG00000121297#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IBA - GO_REF:0000033 $#ENSP00000240587#ENSG00000121297#ENST00000240587#C2H2 ZF Containing Proteins#zf-C2H2_2, zf-C2H2_6, zf-C2HE, zf-met$#ENSP00000475613#ENSG00000121297#ENST00000558569#C2H2 ZF Containing Proteins# FALSE 375 ENSG00000136451 VEZF1 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR007087;IPR015880 7716 vascular endothelial zinc finger 1 [Source:HGNC Symbol;Acc:HGNC:12949] None not tested Yes None None b Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:11504723 No 1a1, Direct HQ evidence Laura Campitelli Sam Lambert Yes None $#ENSP00000258963#ENSG00000136451#ENST00000258963#C2H2 ZF Containing Proteins#$#ENSP00000462337#ENSG00000136451#ENST00000581208#C2H2 ZF Containing Proteins#Spt20, zf-C2H2_4$#ENSP00000463631#ENSG00000136451#ENST00000583932#C2H2 ZF Containing Proteins#$#ENSP00000464687#ENSG00000136451#ENST00000584396#C2H2 ZF Containing Proteins#Spt20, zf-C2H2_4 FALSE 376 ENSG00000011451 WIZ C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif Has a putative AT-hook Regulates the G9aGLP complex for gene repression; has a ChIP-seq derived DNA-binding motif (PMID:25789554). IPR007087;IPR015880 58525 widely interspaced zinc finger motifs [Source:HGNC Symbol;Acc:HGNC:30917] None not tested not tested None None b No No No 5a, one of the source datasets predicts is as a TF Laura Campitelli Jussi Taipale Yes None $#ENSP00000373933#ENSG00000011451#ENST00000389282#C2H2 ZF Containing Proteins#zf-C2H2_4$#ENSP00000445824#ENSG00000011451#ENST00000545156#C2H2 ZF Containing Proteins#zf-C2H2_4$#ENSP00000263381#ENSG00000011451#ENST00000263381#C2H2 ZF Containing Proteins#$#ENSP00000469138#ENSG00000011451#ENST00000596159#C2H2 ZF Containing Proteins#zf-C2H2_4 FALSE 377 ENSG00000184937 WT1 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None Crystal structure (PDB:2JP9) is with dsDNA GCGCAGACGCCCCCGCG, which is consistent with the PWMs IPR000976;IPR007087;IPR015880;IPR017987 7490 Wilms tumor 1 [Source:HGNC Symbol;Acc:HGNC:12796] 2JP9 DBD and Full Yes None Crystal seems fine a Yes No No 1a1, Direct HQ evidence Yimeng Yin Arttu Jolma Yes $#ENSG00000184937#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#ISS - GO_REF:0000024$#ENSG00000184937#GO:0003700#sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024 | NAS - PMID:7862533, PMID:83 $#ENSP00000331327#ENSG00000184937#ENST00000332351#C2H2 ZF Containing Proteins#WT1$#ENSP00000368370#ENSG00000184937#ENST00000379079#C2H2 ZF Containing Proteins#WT1$#ENSP00000415516#ENSG00000184937#ENST00000452863#C2H2 ZF Containing Proteins#WT1$#ENSP00000413452#ENSG00000184937#ENST00000448076#C2H2 ZF Containing Proteins#WT1$#ENSP00000435307#ENSG00000184937#ENST00000530998#C2H2 ZF Containing Proteins#WT1 FALSE 378 ENSG00000100811 YY1 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR007087;IPR015880;IPR017114; 102466730 YY1 transcription factor [Source:HGNC Symbol;Acc:HGNC:12856] 1UBD DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:12584314;7501456;9141463;10452940;7565750;15316102;1655281;1720509 Yes 1a1, Direct HQ evidence Pratyush Das Jussi Taipale Yes $#ENSG00000100811#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#ISS - GO_REF:0000024$#ENSG00000100811#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:1946405 $#ENSP00000262238#ENSG00000100811#ENST00000262238#C2H2 ZF Containing Proteins#$#ENSP00000452140#ENSG00000100811#ENST00000553625#C2H2 ZF Containing Proteins#$#ENSP00000451329#ENSG00000100811#ENST00000554371#C2H2 ZF Containing Proteins#$#ENSP00000452225#ENSG00000100811#ENST00000554804#C2H2 ZF Containing Proteins# FALSE 379 ENSG00000230797 YY2 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR007087;IPR015880;IPR017114; 404281 YY2 transcription factor [Source:HGNC Symbol;Acc:HGNC:31684] None DBD not tested None None a Yes No No 1a1, Direct HQ evidence Laura Campitelli Pratyush Das Yes None $#ENSP00000389381#ENSG00000230797#ENST00000429584#C2H2 ZF Containing Proteins# FALSE 380 ENSG00000126804 ZBTB1 C2H2 ZF Yes Known motif Monomer or homomultimer 100 perc ID - in vitro None None IPR000210;IPR007087;IPR011333;IPR013069;IPR015880; 22890 zinc finger and BTB domain containing 1 [Source:HGNC Symbol;Acc:HGNC:20259] None Full Yes None None b Yes No No 1a1, Direct HQ evidence Sam Lambert Arttu Jolma Yes None $#ENSP00000351587#ENSG00000126804#ENST00000358738#C2H2 ZF Containing Proteins#BTB, zf-C2H2_4$#ENSP00000451000#ENSG00000126804#ENST00000554015#C2H2 ZF Containing Proteins#BTB, zf-C2H2_4$#ENSP00000451584#ENSG00000126804#ENST00000553583#C2H2 ZF Containing Proteins#BTB FALSE 381 ENSG00000205189 ZBTB10 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains and a BTB homodimerization domain IPR000210;IPR007087;IPR011333;IPR013069;IPR015880; 65986 zinc finger and BTB domain containing 10 [Source:HGNC Symbol;Acc:HGNC:30953] None DBD and Full not tested None None b Yes No No 4a, two or more datasets predict it as a TF Jussi Taipale Arttu Jolma No None $#ENSP00000368384#ENSG00000205189#ENST00000379091#C2H2 ZF Containing Proteins#BTB, DUF3342$#ENSP00000412036#ENSG00000205189#ENST00000455036#C2H2 ZF Containing Proteins#BTB, DUF3342, zf-C2H2_4, zf-H2C2_2, zf-H2C2_5$#ENSP00000484716#ENSG00000205189#ENST00000610895#C2H2 ZF Containing Proteins#BTB, DUF3342 FALSE 382 ENSG00000066422 ZBTB11 C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain None IPR000210;IPR007087;IPR011333;IPR013069;IPR015880; 27107 zinc finger and BTB domain containing 11 [Source:HGNC Symbol;Acc:HGNC:16740] None DBD and Full not tested None None b Yes No Yes 2a1, Lower confidence direct evidence Sam Lambert Yimeng Yin Yes $#ENSG00000066422#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000326200#ENSG00000066422#ENST00000312938#C2H2 ZF Containing Proteins#BTB, zf-C2H2_4$#ENSP00000417369#ENSG00000066422#ENST00000461821#C2H2 ZF Containing Proteins# FALSE 383 ENSG00000204366 ZBTB12 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000210;IPR007087;IPR011333;IPR013069;IPR015880; 221527 zinc finger and BTB domain containing 12 [Source:HGNC Symbol;Acc:HGNC:19066] None DBD Yes None None b Yes No No 1a1, Direct HQ evidence Sam Lambert Laura Campitelli Yes None $#ENSP00000364677#ENSG00000204366#ENST00000375527#C2H2 ZF Containing Proteins#BTB FALSE 384 ENSG00000198081 ZBTB14 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000210;IPR007087;IPR011333;IPR013069;IPR015880; 7541 zinc finger and BTB domain containing 14 [Source:HGNC Symbol;Acc:HGNC:12860] None DBD and Full Yes None Badis and Schmitges sboth use outdated symbol ZFP161 a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:8367294;10049742;14706637;15629158 Yes 1a1, Direct HQ evidence Pratyush Das Yimeng Yin Yes $#ENSG00000198081#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:17714511 $#ENSP00000349503#ENSG00000198081#ENST00000357006#C2H2 ZF Containing Proteins#BTB$#ENSP00000383009#ENSG00000198081#ENST00000400143#C2H2 ZF Containing Proteins#BTB$#ENSP00000463414#ENSG00000198081#ENST00000582135#C2H2 ZF Containing Proteins#BTB$#ENSP00000463555#ENSG00000198081#ENST00000582388#C2H2 ZF Containing Proteins#BTB$#ENSP00000484129#ENSG00000198081#ENST00000614697#C2H2 ZF Containing Proteins#BTB$#ENSP00000478971#ENSG00000198081#ENST00000615385#C2H2 ZF Containing Proteins#BTB FALSE 385 ENSG00000109906 ZBTB16 C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain None IPR000210;IPR007087;IPR011333;IPR013069;IPR015880; 7704 zinc finger and BTB domain containing 16 [Source:HGNC Symbol;Acc:HGNC:12930] None DBD and Full not tested None None b Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Other_PMIDS:12408802;12802276 Yes 2a1, Lower confidence direct evidence Laura Campitelli Yimeng Yin Yes $#ENSG00000109906#GO:0001206#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involv#IDA - PMID:12802276 $#ENSP00000338157#ENSG00000109906#ENST00000335953#C2H2 ZF Containing Proteins#BTB, zf-C2H2_4, zf-met$#ENSP00000376721#ENSG00000109906#ENST00000392996#C2H2 ZF Containing Proteins#BTB, zf-C2H2_4, zf-met$#ENSP00000443013#ENSG00000109906#ENST00000535700#C2H2 ZF Containing Proteins#BTB$#ENSP00000437716#ENSG00000109906#ENST00000544220#C2H2 ZF Containing Proteins#BTB FALSE 386 ENSG00000116809 ZBTB17 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR000210;IPR007087;IPR011333;IPR013069;IPR015880; 7709 zinc finger and BTB domain containing 17 [Source:HGNC Symbol;Acc:HGNC:12936] None Full not tested None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:9312026 Yes 3a, decent circumstantial evidence for its role as Yimeng Yin Tim Hughes Yes $#ENSG00000116809#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:12244100 $#ENSP00000364885#ENSG00000116809#ENST00000375733#C2H2 ZF Containing Proteins#BTB, zf-C2H2_4$#ENSP00000364895#ENSG00000116809#ENST00000375743#C2H2 ZF Containing Proteins#BTB, zf-C2H2_4$#ENSP00000438529#ENSG00000116809#ENST00000537142#C2H2 ZF Containing Proteins#zf-C2H2_4$#ENSP00000400827#ENSG00000116809#ENST00000440560#C2H2 ZF Containing Proteins# FALSE 387 ENSG00000179456 ZBTB18 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000210;IPR007087;IPR011333;IPR013069;IPR015880; 10472 zinc finger and BTB domain containing 18 [Source:HGNC Symbol;Acc:HGNC:13030] None DBD and Full Yes None Cell2013 model has old symbol ZNF238 a Yes No Yes 1a1, Direct HQ evidence Sam Lambert Arttu Jolma Yes $#ENSG00000179456#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:9756912, PMID:9770450 $#ENSP00000351539#ENSG00000179456#ENST00000358704#C2H2 ZF Containing Proteins#BTB$#ENSP00000481278#ENSG00000179456#ENST00000622512#C2H2 ZF Containing Proteins#BTB FALSE 388 ENSG00000181472 ZBTB2 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000210;IPR007087;IPR011333;IPR013069;IPR015880; 57621 zinc finger and BTB domain containing 2 [Source:HGNC Symbol;Acc:HGNC:20868] None DBD and Full not tested None None b Yes No No 1a1, Direct HQ evidence Pratyush Das Laura Campitelli Yes None $#ENSP00000323183#ENSG00000181472#ENST00000325144#C2H2 ZF Containing Proteins#BTB FALSE 389 ENSG00000181722 ZBTB20 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000210;IPR007087;IPR011333;IPR013069;IPR015880; 26137 zinc finger and BTB domain containing 20 [Source:HGNC Symbol;Acc:HGNC:13503] None DBD and Full not tested None None b Yes TF Gene Candidate_DNA-Binding: sequence-specific_DNA Binding_PMIDS:11744704 No 1a1, Direct HQ evidence Pratyush Das Sam Lambert Yes $#ENSG00000181722#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019 $#ENSP00000349803#ENSG00000181722#ENST00000357258#C2H2 ZF Containing Proteins#BTB$#ENSP00000377375#ENSG00000181722#ENST00000393785#C2H2 ZF Containing Proteins#BTB$#ENSP00000420324#ENSG00000181722#ENST00000462705#C2H2 ZF Containing Proteins#BTB$#ENSP00000417307#ENSG00000181722#ENST00000464560#C2H2 ZF Containing Proteins#BTB$#ENSP00000419902#ENSG00000181722#ENST00000471418#C2H2 ZF Containing Proteins#BTB$#ENSP00000419153#ENSG00000181722#ENST00000474710#C2H2 ZF Containing Proteins#BTB$#ENSP00000418092#ENSG00000181722#ENST00000481632#C2H2 ZF Containing Proteins#BTB FALSE 390 ENSG00000173276 ZBTB21 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains and a BTB homodimerization domain IPR000210;IPR007087;IPR011333;IPR013069;IPR015880; 49854 zinc finger and BTB domain containing 21 [Source:HGNC Symbol;Acc:HGNC:13083] None DBD and Full not tested None None b Yes No No 4a, two or more datasets predict it as a TF Jussi Taipale Arttu Jolma Yes None $#ENSP00000308759#ENSG00000173276#ENST00000310826#C2H2 ZF Containing Proteins#BTB, zf-C2H2_4$#ENSP00000381510#ENSG00000173276#ENST00000398497#C2H2 ZF Containing Proteins#BTB$#ENSP00000381512#ENSG00000173276#ENST00000398499#C2H2 ZF Containing Proteins#BTB, zf-C2H2_4$#ENSP00000381517#ENSG00000173276#ENST00000398505#C2H2 ZF Containing Proteins#BTB$#ENSP00000381523#ENSG00000173276#ENST00000398511#C2H2 ZF Containing Proteins#BTB, zf-C2H2_4$#ENSP00000395186#ENSG00000173276#ENST00000449949#C2H2 ZF Containing Proteins#BTB$#ENSP00000387788#ENSG00000173276#ENST00000425521#C2H2 ZF Containing Proteins#BTB, DUF3342 FALSE 391 ENSG00000236104 ZBTB22 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000210;IPR007087;IPR011333;IPR013069;IPR015880; 9278 zinc finger and BTB domain containing 22 [Source:HGNC Symbol;Acc:HGNC:13085] None DBD not tested None There are five genes for this protein ENSG00000206280;ENSG00000227780;ENSG00000229253;ENSG00000236104;ENSG00000237056 b Yes No No 1a1, Direct HQ evidence Arttu Jolma Jussi Taipale Yes None $##ENSG00000236104##C2H2 ZF Containing Proteins# FALSE 392 ENSG00000089775 ZBTB25 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR000210;IPR007087;IPR011333;IPR013069;IPR015880; 7597 zinc finger and BTB domain containing 25 [Source:HGNC Symbol;Acc:HGNC:13112] None DBD and Full not tested None None b Yes No Yes 4a, two or more datasets predict it as a TF Sam Lambert Laura Campitelli Yes $#ENSG00000089775#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:2027750 $#ENSP00000450718#ENSG00000089775#ENST00000555220#C2H2 ZF Containing Proteins#BTB$#ENSP00000476746#ENSG00000089775#ENST00000608382#C2H2 ZF Containing Proteins#BTB$#ENSP00000378204#ENSG00000089775#ENST00000394715#C2H2 ZF Containing Proteins#BTB$#ENSP00000451046#ENSG00000089775#ENST00000555424#C2H2 ZF Containing Proteins# FALSE 393 ENSG00000171448 ZBTB26 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000210;IPR007087;IPR011333;IPR013069;IPR015880; 57684 zinc finger and BTB domain containing 26 [Source:HGNC Symbol;Acc:HGNC:23383] None DBD and Full not tested None None b Yes No No 1a1, Direct HQ evidence Jussi Taipale Arttu Jolma Yes None $#ENSP00000362760#ENSG00000171448#ENST00000373656#C2H2 ZF Containing Proteins#BTB$#ENSP00000362758#ENSG00000171448#ENST00000373654#C2H2 ZF Containing Proteins#BTB FALSE 394 ENSG00000185670 ZBTB3 C2H2 ZF Yes Known motif Monomer or homomultimer 100 perc ID - in vitro None None IPR000210;IPR007087;IPR011333;IPR013069;IPR015880; 79842 zinc finger and BTB domain containing 3 [Source:HGNC Symbol;Acc:HGNC:22918] None DBD Yes None None b Yes No No 1a1, Direct HQ evidence Pratyush Das Arttu Jolma No None $#ENSP00000378286#ENSG00000185670#ENST00000394807#C2H2 ZF Containing Proteins#BTB$#ENSP00000432731#ENSG00000185670#ENST00000527994#C2H2 ZF Containing Proteins#BTB FALSE 395 ENSG00000011590 ZBTB32 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000210;IPR007087;IPR011333;IPR013069;IPR015880; 27033 zinc finger and BTB domain containing 32 [Source:HGNC Symbol;Acc:HGNC:16763] None DBD and Full not tested None None b Yes No No 1a1, Direct HQ evidence Jussi Taipale Pratyush Das Yes None $#ENSP00000262630#ENSG00000011590#ENST00000262630#C2H2 ZF Containing Proteins#BTB$#ENSP00000466524#ENSG00000011590#ENST00000426659#C2H2 ZF Containing Proteins#$#ENSP00000376035#ENSG00000011590#ENST00000392197#C2H2 ZF Containing Proteins#BTB FALSE 396 ENSG00000177485 ZBTB33 C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source None None IPR000210;IPR007087;IPR011333;IPR013069;IPR015880; 10009 zinc finger and BTB domain containing 33 [Source:HGNC Symbol;Acc:HGNC:16682] 2LT7 DBD not tested None Also known as Kaiso, crystal structure is nice a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:11445535;14527417 No 1a1, Direct HQ evidence Pratyush Das Arttu Jolma Yes None $#ENSP00000314153#ENSG00000177485#ENST00000326624#C2H2 ZF Containing Proteins#BTB, zf-C2H2_4, zf-H2C2_2$#ENSP00000450969#ENSG00000177485#ENST00000557385#C2H2 ZF Containing Proteins#BTB, zf-C2H2_4, zf-H2C2_2 FALSE 397 ENSG00000177125 ZBTB34 C2H2 ZF Yes Inferred motif Monomer or homomultimer High-throughput in vitro None None IPR000210;IPR007087;IPR011333;IPR013069;IPR015880; 403341 zinc finger and BTB domain containing 34 [Source:HGNC Symbol;Acc:HGNC:31446] None DBD not tested None Taipale Lab, Unpublished HT-SELEX, direct b Yes No No 1a1, Direct HQ evidence Yimeng Yin Sam Lambert Yes None $#ENSP00000317534#ENSG00000177125#ENST00000319119#C2H2 ZF Containing Proteins#BTB, DUF3342$#ENSP00000362551#ENSG00000177125#ENST00000373452#C2H2 ZF Containing Proteins#BTB, DUF3342 FALSE 398 ENSG00000185278 ZBTB37 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000210;IPR007087;IPR011333;IPR013069;IPR015880; 84614 zinc finger and BTB domain containing 37 [Source:HGNC Symbol;Acc:HGNC:28365] None DBD and Full not tested None None b Yes No No 1a1, Direct HQ evidence Arttu Jolma Laura Campitelli Yes None $#ENSP00000356674#ENSG00000185278#ENST00000367701#C2H2 ZF Containing Proteins#BTB, DUF3342$#ENSP00000356677#ENSG00000185278#ENST00000367704#C2H2 ZF Containing Proteins#BTB, DUF3342$#ENSP00000356675#ENSG00000185278#ENST00000367702#C2H2 ZF Containing Proteins#BTB, DUF3342$#ENSP00000415293#ENSG00000185278#ENST00000427304#C2H2 ZF Containing Proteins#BTB, DUF3342 FALSE 399 ENSG00000177311 ZBTB38 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None It has a decent cassette of znfC2H2 domains and a BTB homodimerization domain. Requires CpG methylation for binding into a site in MYOG-promoter (PMID: 21625269). IPR000210;IPR007087;IPR011333;IPR013069;IPR015880; 253461 zinc finger and BTB domain containing 38 [Source:HGNC Symbol;Acc:HGNC:26636] None Full not tested None None a Yes No Yes 4a, two or more datasets predict it as a TF Sam Lambert Arttu Jolma Yes $#ENSG00000177311#GO:0003700#sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024 $#ENSP00000426931#ENSG00000177311#ENST00000509842#C2H2 ZF Containing Proteins#BTB$#ENSP00000424254#ENSG00000177311#ENST00000509883#C2H2 ZF Containing Proteins#BTB, zf-C2H2_4, zf-C2H2_6$#ENSP00000422757#ENSG00000177311#ENST00000513570#C2H2 ZF Containing Proteins#BTB$#ENSP00000406955#ENSG00000177311#ENST00000441582#C2H2 ZF Containing Proteins#BTB, zf-C2H2_4, zf-C2H2_6$#ENSP00000421037#ENSG00000177311#ENST00000507722#C2H2 ZF Containing Proteins#BTB$#ENSP00000425705#ENSG00000177311#ENST00000510338#C2H2 ZF Containing Proteins#BTB$#ENSP00000426387#ENSG00000177311#ENST00000514251#C2H2 ZF Containing Proteins#BTB, zf-C2H2_4, zf-C2H2_6$#ENSP00000422347#ENSG00000177311#ENST00000504673#C2H2 ZF Containing Proteins#BTB$#ENSP00000422894#ENSG00000177311#ENST00000509813#C2H2 ZF Containing Proteins#BTB$#ENSP00000422081#ENSG00000177311#ENST00000510726#C2H2 ZF Containing Proteins#BTB$#ENSP00000372635#ENSG00000177311#ENST00000321464#C2H2 ZF Containing Proteins#BTB, zf-C2H2_4, zf-C2H2_6$#ENSP00000490370#ENSG00000177311#ENST00000636289#C2H2 ZF Containing Proteins#BTB, zf-C2H2_4, zf-C2H2_6$#ENSP00000490041#ENSG00000177311#ENST00000637056#C2H2 ZF Containing Proteins#BTB, zf-C2H2_4, zf-C2H2_6 FALSE 400 ENSG00000166860 ZBTB39 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR000210;IPR007087;IPR011333;IPR013069;IPR015880; 9880 zinc finger and BTB domain containing 39 [Source:HGNC Symbol;Acc:HGNC:29014] None Full Yes None None b Yes No No 4a, two or more datasets predict it as a TF Pratyush Das Sam Lambert Yes None $#ENSP00000300101#ENSG00000166860#ENST00000300101#C2H2 ZF Containing Proteins#BTB, zf-C2H2_4 FALSE 401 ENSG00000174282 ZBTB4 C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain None IPR000210;IPR007087;IPR011333;IPR013069;IPR015880; 57659 zinc finger and BTB domain containing 4 [Source:HGNC Symbol;Acc:HGNC:23847] None DBD and Full not tested None None a Yes No Yes 2a1, Lower confidence direct evidence Jussi Taipale Pratyush Das Yes $#ENSG00000174282#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IDA - PMID:16354688 $#ENSP00000307858#ENSG00000174282#ENST00000311403#C2H2 ZF Containing Proteins#BTB$#ENSP00000369973#ENSG00000174282#ENST00000380599#C2H2 ZF Containing Proteins#BTB FALSE 402 ENSG00000184677 ZBTB40 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains and a BTB homodimerization domain IPR000210;IPR007087;IPR011333;IPR013069;IPR015880; 9923 zinc finger and BTB domain containing 40 [Source:HGNC Symbol;Acc:HGNC:29045] None DBD and Full not tested None None b Yes No No 4a, two or more datasets predict it as a TF Laura Campitelli Arttu Jolma Yes None $#ENSP00000363782#ENSG00000184677#ENST00000374651#C2H2 ZF Containing Proteins#BTB, zf-C2H2_4$#ENSP00000364798#ENSG00000184677#ENST00000375647#C2H2 ZF Containing Proteins#BTB, zf-C2H2_4$#ENSP00000383098#ENSG00000184677#ENST00000400239#C2H2 ZF Containing Proteins#BTB$#ENSP00000384527#ENSG00000184677#ENST00000404138#C2H2 ZF Containing Proteins#BTB, zf-C2H2_4 FALSE 403 ENSG00000177888 ZBTB41 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR000210;IPR007087;IPR011333;IPR013069;IPR015880; 360023 zinc finger and BTB domain containing 41 [Source:HGNC Symbol;Acc:HGNC:24819] None not tested not tested None None b Yes No No 4a, two or more datasets predict it as a TF Sam Lambert Laura Campitelli Yes None $#ENSP00000356375#ENSG00000177888#ENST00000367405#C2H2 ZF Containing Proteins#BTB FALSE 404 ENSG00000179627 ZBTB42 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR000210;IPR007087;IPR011333;IPR013069;IPR015880; 100128927 zinc finger and BTB domain containing 42 [Source:HGNC Symbol;Acc:HGNC:32550] None not tested not tested None TFs that are in CisBP but not in Vaquerizas set No Yes No No 1a1, Direct HQ evidence Sam Lambert Pratyush Das Yes None $#ENSP00000450673#ENSG00000179627#ENST00000555360#C2H2 ZF Containing Proteins#BTB$#ENSP00000409107#ENSG00000179627#ENST00000342537#C2H2 ZF Containing Proteins#BTB FALSE 405 ENSG00000169155 ZBTB43 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000210;IPR007087;IPR011333;IPR013069;IPR015880; 23099 zinc finger and BTB domain containing 43 [Source:HGNC Symbol;Acc:HGNC:17908] None DBD and Full Yes None None b Yes No No 1a1, Direct HQ evidence Laura Campitelli Yimeng Yin Yes None $#ENSP00000362563#ENSG00000169155#ENST00000373464#C2H2 ZF Containing Proteins#BTB$#ENSP00000390344#ENSG00000169155#ENST00000449886#C2H2 ZF Containing Proteins#BTB$#ENSP00000412145#ENSG00000169155#ENST00000450858#C2H2 ZF Containing Proteins#BTB$#ENSP00000362556#ENSG00000169155#ENST00000373457#C2H2 ZF Containing Proteins#BTB FALSE 406 ENSG00000196323 ZBTB44 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000210;IPR007087;IPR011333;IPR013069;IPR015880; 29068 Zinc finger and BTB domain containing 44 [Source:HGNC Symbol;Acc:HGNC:25001] None Full not tested None None b Yes No No 4a, two or more datasets predict it as a TF Sam Lambert Pratyush Das Yes None $#ENSP00000350574#ENSG00000196323#ENST00000357899#C2H2 ZF Containing Proteins#BTB$#ENSP00000433457#ENSG00000196323#ENST00000525842#C2H2 ZF Containing Proteins#BTB$#ENSP00000434177#ENSG00000196323#ENST00000530205#C2H2 ZF Containing Proteins#BTB$#ENSP00000432558#ENSG00000196323#ENST00000529982#C2H2 ZF Containing Proteins# FALSE 407 ENSG00000119574 ZBTB45 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000210;IPR007087;IPR011333;IPR013069;IPR015880; 84878 zinc finger and BTB domain containing 45 [Source:HGNC Symbol;Acc:HGNC:23715] None DBD and Full not tested None None b Yes No No 1a1, Direct HQ evidence Tim Hughes Sam Lambert Yes None $#ENSP00000346603#ENSG00000119574#ENST00000354590#C2H2 ZF Containing Proteins#BTB$#ENSP00000469089#ENSG00000119574#ENST00000594051#C2H2 ZF Containing Proteins#BTB$#ENSP00000470316#ENSG00000119574#ENST00000600130#C2H2 ZF Containing Proteins#BTB$#ENSP00000471885#ENSG00000119574#ENST00000596739#C2H2 ZF Containing Proteins# FALSE 408 ENSG00000130584 ZBTB46 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Specificity is unknown; functions in dendritic cells (PMID: 22615130). IPR000210;IPR007087;IPR011333;IPR013069;IPR015880; 140685 zinc finger and BTB domain containing 46 [Source:HGNC Symbol;Acc:HGNC:16094] None DBD and Full not tested None None b Yes No No 4a, two or more datasets predict it as a TF Sam Lambert Arttu Jolma Yes None $#ENSP00000303102#ENSG00000130584#ENST00000302995#C2H2 ZF Containing Proteins#BTB, BTB_3, DUF3342$#ENSP00000378536#ENSG00000130584#ENST00000395104#C2H2 ZF Containing Proteins#BTB, BTB_3, DUF3342$#ENSP00000245663#ENSG00000130584#ENST00000245663#C2H2 ZF Containing Proteins#BTB, BTB_3, DUF3342 FALSE 409 ENSG00000114853 ZBTB47 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR000210;IPR007087;IPR011333;IPR013069;IPR015880; 92999 zinc finger and BTB domain containing 47 [Source:HGNC Symbol;Acc:HGNC:26955] None Full not tested None None b Yes No No 1a2, Orthologous HQ evidence Jussi Taipale Laura Campitelli Yes None $#ENSP00000232974#ENSG00000114853#ENST00000232974#C2H2 ZF Containing Proteins#BTB, zf-C2H2_4, zf-C2H2_6$#ENSP00000420968#ENSG00000114853#ENST00000505904#C2H2 ZF Containing Proteins#zf-C2H2_4, zf-C2H2_6 FALSE 410 ENSG00000204859 ZBTB48 C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect None IPR000210;IPR007087;IPR011333;IPR013069;IPR015880; 3104 zinc finger and BTB domain containing 48 [Source:HGNC Symbol;Acc:HGNC:4930] None DBD and Full not tested None None a Yes No Yes 1a1, Direct HQ evidence Jussi Taipale Sam Lambert Yes $#ENSG00000204859#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:8661141 $#ENSP00000366902#ENSG00000204859#ENST00000377674#C2H2 ZF Containing Proteins#BTB$#ENSP00000313416#ENSG00000204859#ENST00000319084#C2H2 ZF Containing Proteins#BTB$#ENSP00000466390#ENSG00000204859#ENST00000488936#C2H2 ZF Containing Proteins#$#ENSP00000416054#ENSG00000204859#ENST00000435905#C2H2 ZF Containing Proteins#BTB FALSE 411 ENSG00000168826 ZBTB49 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000210;IPR007087;IPR011333;IPR013069;IPR015880;IPR020542 166793 zinc finger and BTB domain containing 49 [Source:HGNC Symbol;Acc:HGNC:19883] None DBD and Full not tested None None b Yes No No 1a1, Direct HQ evidence Sam Lambert Jussi Taipale Yes None $#ENSP00000338807#ENSG00000168826#ENST00000337872#C2H2 ZF Containing Proteins#BTB$#ENSP00000421654#ENSG00000168826#ENST00000504302#C2H2 ZF Containing Proteins#$#ENSP00000425747#ENSG00000168826#ENST00000502918#C2H2 ZF Containing Proteins#BTB FALSE 412 ENSG00000168795 ZBTB5 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif Single C2H2 domain Binds to GATCGGGCGGGGCGGTTGTATATCA; GATCCGTTAGAGGAAGAAGACTGGGCATGTCTG and GATCCATCAGGAACATGTCCCAACATGTTGAGCTC based on EMSA using recombinant protein (PMID: 19491398). IPR000210;IPR007087;IPR011333;IPR013069;IPR015880; 9925 zinc finger and BTB domain containing 5 [Source:HGNC Symbol;Acc:HGNC:23836] None DBD and Full not tested None None b Yes No No 4a, two or more datasets predict it as a TF Arttu Jolma Laura Campitelli Yes None $#ENSP00000307604#ENSG00000168795#ENST00000307750#C2H2 ZF Containing Proteins#BTB, DUF3342, zf-C2H2_4, zf-H2C2_2 FALSE 413 ENSG00000186130 ZBTB6 C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect None IPR000210;IPR007087;IPR011333;IPR013069;IPR015880; 10773 zinc finger and BTB domain containing 6 [Source:HGNC Symbol;Acc:HGNC:16764] None DBD and Full not tested None None b Yes No No 1a1, Direct HQ evidence Yimeng Yin Laura Campitelli Yes None $#ENSP00000362763#ENSG00000186130#ENST00000373659#C2H2 ZF Containing Proteins#BTB FALSE 414 ENSG00000178951 ZBTB7A C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000210;IPR007087;IPR011333;IPR013069;IPR015880; 51341 zinc finger and BTB domain containing 7A [Source:HGNC Symbol;Acc:HGNC:18078] None DBD and Full not tested None None a Yes No No 1a1, Direct HQ evidence Yimeng Yin Pratyush Das Yes $#ENSG00000178951#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019 $#ENSP00000323670#ENSG00000178951#ENST00000322357#C2H2 ZF Containing Proteins#BTB$#ENSP00000471865#ENSG00000178951#ENST00000601588#C2H2 ZF Containing Proteins#BTB FALSE 415 ENSG00000160685 ZBTB7B C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000210;IPR007087;IPR011333;IPR013069;IPR015880; 51043 zinc finger and BTB domain containing 7B [Source:HGNC Symbol;Acc:HGNC:18668] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:7937772 No 1a1, Direct HQ evidence Arttu Jolma Pratyush Das Yes None $#ENSP00000292176#ENSG00000160685#ENST00000292176#C2H2 ZF Containing Proteins#BTB$#ENSP00000357411#ENSG00000160685#ENST00000368426#C2H2 ZF Containing Proteins#BTB$#ENSP00000406286#ENSG00000160685#ENST00000417934#C2H2 ZF Containing Proteins#BTB$#ENSP00000438647#ENSG00000160685#ENST00000535420#C2H2 ZF Containing Proteins#BTB FALSE 416 ENSG00000184828 ZBTB7C C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000210;IPR007087;IPR011333;IPR013069;IPR015880;IPR016024 201501 zinc finger and BTB domain containing 7C [Source:HGNC Symbol;Acc:HGNC:31700] None Full not tested None None b Yes No No 1a1, Direct HQ evidence Arttu Jolma Pratyush Das Yes None $#ENSP00000439781#ENSG00000184828#ENST00000535628#C2H2 ZF Containing Proteins#BTB$#ENSP00000464724#ENSG00000184828#ENST00000585404#C2H2 ZF Containing Proteins#$#ENSP00000466944#ENSG00000184828#ENST00000586047#C2H2 ZF Containing Proteins#$#ENSP00000468254#ENSG00000184828#ENST00000586438#C2H2 ZF Containing Proteins#BTB$#ENSP00000468537#ENSG00000184828#ENST00000586525#C2H2 ZF Containing Proteins#$#ENSP00000466006#ENSG00000184828#ENST00000586743#C2H2 ZF Containing Proteins#$#ENSP00000465760#ENSG00000184828#ENST00000587107#C2H2 ZF Containing Proteins#$#ENSP00000468152#ENSG00000184828#ENST00000588028#C2H2 ZF Containing Proteins#$#ENSP00000466088#ENSG00000184828#ENST00000588053#C2H2 ZF Containing Proteins#$#ENSP00000468814#ENSG00000184828#ENST00000588149#C2H2 ZF Containing Proteins#$#ENSP00000467456#ENSG00000184828#ENST00000588566#C2H2 ZF Containing Proteins#$#ENSP00000468502#ENSG00000184828#ENST00000588970#C2H2 ZF Containing Proteins#$#ENSP00000468782#ENSG00000184828#ENST00000588982#C2H2 ZF Containing Proteins#BTB$#ENSP00000467147#ENSG00000184828#ENST00000589077#C2H2 ZF Containing Proteins#$#ENSP00000467338#ENSG00000184828#ENST00000589170#C2H2 ZF Containing Proteins#$#ENSP00000468019#ENSG00000184828#ENST00000589194#C2H2 ZF Containing Proteins#$#ENSP00000465160#ENSG00000184828#ENST00000590178#C2H2 ZF Containing Proteins#$#ENSP00000465494#ENSG00000184828#ENST00000590374#C2H2 ZF Containing Proteins#$#ENSP00000467323#ENSG00000184828#ENST00000590437#C2H2 ZF Containing Proteins#BTB$#ENSP00000467877#ENSG00000184828#ENST00000590800#C2H2 ZF Containing Proteins#BTB$#ENSP00000468306#ENSG00000184828#ENST00000590855#C2H2 ZF Containing Proteins#$#ENSP00000465265#ENSG00000184828#ENST00000591279#C2H2 ZF Containing Proteins#$#ENSP00000467758#ENSG00000184828#ENST00000591405#C2H2 ZF Containing Proteins#$#ENSP00000468752#ENSG00000184828#ENST00000591526#C2H2 ZF Containing Proteins#$#ENSP00000465835#ENSG00000184828#ENST00000592387#C2H2 ZF Containing Proteins#$#ENSP00000468087#ENSG00000184828#ENST00000592656#C2H2 ZF Containing Proteins#$#ENSP00000465832#ENSG00000184828#ENST00000593159#C2H2 ZF Containing Proteins# FALSE 417 ENSG00000160062 ZBTB8A C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Virtually nothing is known for this protein except that it has a two znfC2H2 domains and a BTB-domain IPR000210;IPR007087;IPR011333;IPR013069;IPR015880; 653121 zinc finger and BTB domain containing 8A [Source:HGNC Symbol;Acc:HGNC:24172] None Full not tested None None b Yes No No 4a, two or more datasets predict it as a TF Arttu Jolma Jussi Taipale No None $#ENSP00000317561#ENSG00000160062#ENST00000316459#C2H2 ZF Containing Proteins#BTB, BTB_2, DUF3342$#ENSP00000362609#ENSG00000160062#ENST00000373510#C2H2 ZF Containing Proteins#BTB, BTB_2, DUF3342 FALSE 418 ENSG00000273274 ZBTB8B C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains and a BTB homodimerization domain IPR007087;IPR000210;IPR015880; 728116 zinc finger and BTB domain containing 8B [Source:HGNC Symbol;Acc:HGNC:37057] None not tested not tested None None b Yes No No 4a, two or more datasets predict it as a TF Arttu Jolma Sam Lambert Yes None $#ENSP00000476499#ENSG00000273274#ENST00000609129#C2H2 ZF Containing Proteins#BTB, DUF3342, Ribosomal_60s FALSE 419 ENSG00000213588 ZBTB9 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Virtually nothing is known for this protein except that it has two znfC2H2 domains and a BTB-domain that typically mediates homotypic dimerization IPR000210;IPR007087;IPR011333;IPR013069;IPR015880; 221504 zinc finger and BTB domain containing 9 [Source:HGNC Symbol;Acc:HGNC:28323] None DBD not tested None None b Yes No No 4a, two or more datasets predict it as a TF Jussi Taipale Arttu Jolma No None $#ENSP00000378503#ENSG00000213588#ENST00000395064#C2H2 ZF Containing Proteins#BTB$#ENSP00000478118#ENSG00000213588#ENST00000612407#C2H2 ZF Containing Proteins#$#ENSP00000484571#ENSG00000213588#ENST00000612775#C2H2 ZF Containing Proteins#BTB$#ENSP00000484265#ENSG00000213588#ENST00000621915#C2H2 ZF Containing Proteins#BTB FALSE 420 ENSG00000066827 ZFAT C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif Has a putative AT-hook None IPR007087;IPR015880 57623 zinc finger and AT-hook domain containing [Source:HGNC Symbol;Acc:HGNC:19899] None DBD not tested None None b Yes No Yes 4a, two or more datasets predict it as a TF Yimeng Yin Sam Lambert Yes $#ENSG00000066827#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000066827#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000367069#ENSG00000066827#ENST00000377838#C2H2 ZF Containing Proteins#zf-C2H2_4, zf-Di19, zf-H2C2_5$#ENSP00000394501#ENSG00000066827#ENST00000429442#C2H2 ZF Containing Proteins#zf-C2H2_4, zf-Di19, zf-H2C2_5$#ENSP00000428483#ENSG00000066827#ENST00000520214#C2H2 ZF Containing Proteins#zf-Di19$#ENSP00000427879#ENSG00000066827#ENST00000520356#C2H2 ZF Containing Proteins#zf-C2H2_4, zf-Di19, zf-H2C2_5$#ENSP00000427831#ENSG00000066827#ENST00000520727#C2H2 ZF Containing Proteins#zf-Di19$#ENSP00000429091#ENSG00000066827#ENST00000523399#C2H2 ZF Containing Proteins#zf-C2H2_4, zf-Di19, zf-H2C2_5$#ENSP00000429600#ENSG00000066827#ENST00000521673#C2H2 ZF Containing Proteins# FALSE 421 ENSG00000184517 ZFP1 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001909;IPR007087;IPR015880; 162239 ZFP1 zinc finger protein [Source:HGNC Symbol;Acc:HGNC:23328] None DBD Yes None None b Yes No Yes 1a1, Direct HQ evidence Jussi Taipale Pratyush Das Yes $#ENSG00000184517#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000333192#ENSG00000184517#ENST00000332307#C2H2 ZF Containing Proteins#KRAB$#ENSP00000377080#ENSG00000184517#ENST00000393430#C2H2 ZF Containing Proteins#KRAB$#ENSP00000457941#ENSG00000184517#ENST00000464850#C2H2 ZF Containing Proteins#KRAB$#ENSP00000454286#ENSG00000184517#ENST00000568079#C2H2 ZF Containing Proteins#$#ENSP00000457044#ENSG00000184517#ENST00000570010#C2H2 ZF Containing Proteins#KRAB TRUE 422 ENSG00000142065 ZFP14 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 57677 ZFP14 zinc finger protein [Source:HGNC Symbol;Acc:HGNC:29312] None Full Yes None None b Yes No Yes 1a1, Direct HQ evidence Laura Campitelli Arttu Jolma Yes $#ENSG00000142065#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000270001#ENSG00000142065#ENST00000270001#C2H2 ZF Containing Proteins#KRAB$#ENSP00000466416#ENSG00000142065#ENST00000589280#C2H2 ZF Containing Proteins#KRAB TRUE 423 ENSG00000198939 ZFP2 C2H2 ZF Yes Inferred motif Monomer or homomultimer In vivo/Misc source None None IPR007087;IPR015880 80108 ZFP2 zinc finger protein [Source:HGNC Symbol;Acc:HGNC:26138] None Full not tested None None b Yes No Yes 1a2, Orthologous HQ evidence Sam Lambert Yimeng Yin Yes $#ENSG00000198939#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000354453#ENSG00000198939#ENST00000361362#C2H2 ZF Containing Proteins#$#ENSP00000430531#ENSG00000198939#ENST00000523286#C2H2 ZF Containing Proteins#$#ENSP00000429095#ENSG00000198939#ENST00000520660#C2H2 ZF Containing Proteins#$#ENSP00000431074#ENSG00000198939#ENST00000520805#C2H2 ZF Containing Proteins# FALSE 424 ENSG00000196867 ZFP28 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE); Has a putative AT-hook None IPR001909;IPR007087;IPR015880; 140612 ZFP28 zinc finger protein [Source:HGNC Symbol;Acc:HGNC:17801] None DBD and Full not tested None None b Yes No Yes 1a1, Direct HQ evidence Laura Campitelli Arttu Jolma Yes $#ENSG00000196867#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000301318#ENSG00000196867#ENST00000301318#C2H2 ZF Containing Proteins#KRAB$#ENSP00000468603#ENSG00000196867#ENST00000591844#C2H2 ZF Containing Proteins#KRAB TRUE 425 ENSG00000180787 ZFP3 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR007087;IPR015880 124961 ZFP3 zinc finger protein [Source:HGNC Symbol;Acc:HGNC:12861] None Full Yes None None b Yes No Yes 1a1, Direct HQ evidence Jussi Taipale Yimeng Yin Yes $#ENSG00000180787#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000320347#ENSG00000180787#ENST00000318833#C2H2 ZF Containing Proteins# FALSE 426 ENSG00000120784 ZFP30 C2H2 ZF Yes Inferred motif Monomer or homomultimer High-throughput in vitro None None IPR001909;IPR007087;IPR015880; 22835 ZFP30 zinc finger protein [Source:HGNC Symbol;Acc:HGNC:29555] None DBD not tested None None b Yes No Yes 4a, two or more datasets predict it as a TF Jussi Taipale Sam Lambert Yes $#ENSG00000120784#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000343581#ENSG00000120784#ENST00000351218#C2H2 ZF Containing Proteins#KRAB, zf-C2H2_4$#ENSP00000422930#ENSG00000120784#ENST00000514101#C2H2 ZF Containing Proteins#KRAB, zf-C2H2_4$#ENSP00000466563#ENSG00000120784#ENST00000587809#C2H2 ZF Containing Proteins#KRAB$#ENSP00000465496#ENSG00000120784#ENST00000588979#C2H2 ZF Containing Proteins#KRAB TRUE 427 ENSG00000136866 ZFP37 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR001909;IPR007087;IPR015880; 7539 ZFP37 zinc finger protein [Source:HGNC Symbol;Acc:HGNC:12863] None Full not tested None None b Yes No Yes 4a, two or more datasets predict it as a TF Sam Lambert Pratyush Das Yes $#ENSG00000136866#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:9585434 $#ENSP00000363344#ENSG00000136866#ENST00000374227#C2H2 ZF Containing Proteins#KRAB, zf-C2H2_4$#ENSP00000451310#ENSG00000136866#ENST00000555206#C2H2 ZF Containing Proteins#KRAB, zf-C2H2_4$#ENSP00000452552#ENSG00000136866#ENST00000553380#C2H2 ZF Containing Proteins#KRAB, zf-C2H2_4 TRUE 428 ENSG00000181638 ZFP41 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR007087;IPR015880 286128 ZFP41 zinc finger protein [Source:HGNC Symbol;Acc:HGNC:26786] None Full not tested None None b Yes No No 1a1, Direct HQ evidence Arttu Jolma Jussi Taipale Yes None $#ENSP00000430465#ENSG00000181638#ENST00000520584#C2H2 ZF Containing Proteins#$#ENSP00000327427#ENSG00000181638#ENST00000330701#C2H2 ZF Containing Proteins# FALSE 429 ENSG00000179059 ZFP42 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR007087;IPR015880 132625 ZFP42 zinc finger protein [Source:HGNC Symbol;Acc:HGNC:30949] None DBD and Full not tested None None b Yes Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0 Yes 1a1, Direct HQ evidence Sam Lambert Laura Campitelli Yes $#ENSG00000179059#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:14688391 $#ENSP00000317686#ENSG00000179059#ENST00000326866#C2H2 ZF Containing Proteins#$#ENSP00000424662#ENSG00000179059#ENST00000509524#C2H2 ZF Containing Proteins#$#ENSP00000483363#ENSG00000179059#ENST00000618147#C2H2 ZF Containing Proteins# FALSE 430 ENSG00000204644 ZFP57 C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect Recognizes CpG methylated ACTGCGGCAAT site based on structure 4GZN IPR001909;IPR007087;IPR015880; 346171 ZFP57 zinc finger protein [Source:HGNC Symbol;Acc:HGNC:18791] 4GZN not tested not tested None None b Yes Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0 No 1a1, Direct HQ evidence Laura Campitelli Arttu Jolma Yes None $#ENSP00000418259#ENSG00000204644#ENST00000488757#C2H2 ZF Containing Proteins#KRAB$#ENSP00000366078#ENSG00000204644#ENST00000376881#C2H2 ZF Containing Proteins#KRAB$#ENSP00000366080#ENSG00000204644#ENST00000376883#C2H2 ZF Containing Proteins#KRAB TRUE 431 ENSG00000196670 ZFP62 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains IPR007087;IPR015880 643836 ZFP62 zinc finger protein [Source:HGNC Symbol;Acc:HGNC:23241] None DBD Yes None None b Yes No No 4a, two or more datasets predict it as a TF Yimeng Yin Arttu Jolma Yes None $#ENSP00000423820#ENSG00000196670#ENST00000502412#C2H2 ZF Containing Proteins#$#ENSP00000422987#ENSG00000196670#ENST00000504225#C2H2 ZF Containing Proteins#$#ENSP00000426193#ENSG00000196670#ENST00000512132#C2H2 ZF Containing Proteins# FALSE 432 ENSG00000020256 ZFP64 C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect None IPR007087;IPR015880 55734 ZFP64 zinc finger protein [Source:HGNC Symbol;Acc:HGNC:15940] None DBD and Full not tested None None b Yes Indeterminate - There is no evidence for or against this genes role as a TF__Other_PMIDS:9034307; No 1a1, Direct HQ evidence Jussi Taipale Tim Hughes Yes None $#ENSP00000216923#ENSG00000020256#ENST00000216923#C2H2 ZF Containing Proteins#zf-H2C2_5$#ENSP00000355179#ENSG00000020256#ENST00000361387#C2H2 ZF Containing Proteins#zf-H2C2_5$#ENSP00000360570#ENSG00000020256#ENST00000371515#C2H2 ZF Containing Proteins#zf-H2C2_5$#ENSP00000360573#ENSG00000020256#ENST00000371518#C2H2 ZF Containing Proteins#zf-H2C2_5$#ENSP00000344615#ENSG00000020256#ENST00000346617#C2H2 ZF Containing Proteins#zf-H2C2_5$#ENSP00000360578#ENSG00000020256#ENST00000371523#C2H2 ZF Containing Proteins#zf-H2C2_5$#ENSP00000379303#ENSG00000020256#ENST00000395979#C2H2 ZF Containing Proteins#$#ENSP00000403424#ENSG00000020256#ENST00000456175#C2H2 ZF Containing Proteins#zf-C2H2_4, zf-H2C2_5 FALSE 433 ENSG00000187815 ZFP69 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 339559 ZFP69 zinc finger protein [Source:HGNC Symbol;Acc:HGNC:24708] None DBD and Full not tested None None b Yes No No 1a1, Direct HQ evidence Laura Campitelli Yimeng Yin Yes None $#ENSP00000361791#ENSG00000187815#ENST00000372706#C2H2 ZF Containing Proteins#KRAB, SCAN$#ENSP00000361790#ENSG00000187815#ENST00000372705#C2H2 ZF Containing Proteins#KRAB, SCAN TRUE 434 ENSG00000187801 ZFP69B C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR003309;IPR007087;IPR008916;IPR015880; 65243 ZFP69 zinc finger protein B [Source:HGNC Symbol;Acc:HGNC:28053] None Full not tested None None b Yes No Yes 1a1, Direct HQ evidence Pratyush Das Arttu Jolma Yes $#ENSG00000187801#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002 $#ENSP00000354547#ENSG00000187801#ENST00000361584#C2H2 ZF Containing Proteins#KRAB, SCAN$#ENSP00000435907#ENSG00000187801#ENST00000484445#C2H2 ZF Containing Proteins#SCAN$#ENSP00000399664#ENSG00000187801#ENST00000411995#C2H2 ZF Containing Proteins#KRAB, SCAN TRUE 435 ENSG00000181007 ZFP82 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 284406 ZFP82 zinc finger protein [Source:HGNC Symbol;Acc:HGNC:28682] None DBD and Full not tested None None b Yes No Yes 1a1, Direct HQ evidence Arttu Jolma Jussi Taipale Yes $#ENSG00000181007#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000431265#ENSG00000181007#ENST00000392161#C2H2 ZF Containing Proteins#KRAB, zf-C2H2_4, zf-C2H2_6$#ENSP00000468212#ENSG00000181007#ENST00000445543#C2H2 ZF Containing Proteins# TRUE 436 ENSG00000184939 ZFP90 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 146198 ZFP90 zinc finger protein [Source:HGNC Symbol;Acc:HGNC:23329] None Full not tested None None x Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:7576184;11501753 No 1a1, Direct HQ evidence Laura Campitelli Arttu Jolma Yes $#ENSG00000184939#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019 $#ENSP00000454418#ENSG00000184939#ENST00000563169#C2H2 ZF Containing Proteins#KRAB$#ENSP00000460547#ENSG00000184939#ENST00000570495#C2H2 ZF Containing Proteins#KRAB$#ENSP00000480309#ENSG00000184939#ENST00000611381#C2H2 ZF Containing Proteins#KRAB$#ENSP00000458410#ENSG00000184939#ENST00000573113#C2H2 ZF Containing Proteins#KRAB$#ENSP00000459846#ENSG00000184939#ENST00000573161#C2H2 ZF Containing Proteins# TRUE 437 ENSG00000186660 ZFP91 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Possible false positive. An Atypical E3 ubiquitin-protein ligase that mediates Lys-63-linked ubiquitination of MAP3K14/NIK; leading to stabilization and activation of MAP3K14/NIK. It thereby acts as an activator of the non-canonical NF-kappa-B2/NFKB2 pathway (PMID: 20682767). IPR007087;IPR015880 80829 ZFP91 zinc finger protein [Source:HGNC Symbol;Acc:HGNC:14983] None Full not tested None None b Yes No No 4a, two or more datasets predict it as a TF Arttu Jolma Laura Campitelli Yes None $#ENSP00000339030#ENSG00000186660#ENST00000316059#C2H2 ZF Containing Proteins# FALSE 438 ENSG00000189420 ZFP92 C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains and a KRAB-domain IPR001909;IPR007087;IPR015880; 139735 ZFP92 zinc finger protein [Source:HGNC Symbol;Acc:HGNC:12865] None not tested not tested None None c Yes No No 2a2, orthologous lower confidence evidence Arttu Jolma Pratyush Das Yes None $#ENSP00000462054#ENSG00000189420#ENST00000338647#C2H2 ZF Containing Proteins#KRAB TRUE 439 ENSG00000162300 ZFPL1 C2H2 ZF No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Protein is a Golgi apparatus integral membrane protein with RING-type zinc fingers (PMID:18323775 ). None None Zinc finger protein like 1 None not tested not tested None Protein is a Golgi apparatus integral membrane protein with RING-type zinc fingers (PMID:18323775 ). No No No No Protein added after initial stage, no initial assesment Arttu Jolma Sam Lambert No None None FALSE 440 ENSG00000179588 ZFPM1 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR007087;IPR015880 161882 zinc finger protein, FOG family member 1 [Source:HGNC Symbol;Acc:HGNC:19762] None not tested not tested None None a Yes TF Gene_Transcription Factor Binding: tf co-factor binding_Other_PMIDS:9230307 Yes 3a, decent circumstantial evidence for its role as Pratyush Das Jussi Taipale Yes $#ENSG00000179588#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:15920471 $#ENSP00000326630#ENSG00000179588#ENST00000319555#C2H2 ZF Containing Proteins#zf-C2H2_4, zf-C2H2_jaz, zf-met$#ENSP00000480412#ENSG00000179588#ENST00000562437#C2H2 ZF Containing Proteins#$#ENSP00000484216#ENSG00000179588#ENST00000563351#C2H2 ZF Containing Proteins#$#ENSP00000482796#ENSG00000179588#ENST00000569086#C2H2 ZF Containing Proteins# FALSE 441 ENSG00000169946 ZFPM2 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None FOG-proteins use some of their zinc-fingers to interact with the GATA proteins. Other C2H2 ZFs are probably also capable of binding DNA (PMID: 10329627). IPR007087;IPR015880 23414 zinc finger protein, FOG family member 2 [Source:HGNC Symbol;Acc:HGNC:16700] None Full not tested None None a Yes TF Gene Candidate__Co-activation_PMIDS:9927675;10330188;10438528 Yes 3a, decent circumstantial evidence for its role as Sam Lambert Arttu Jolma Yes $#ENSG00000169946#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IBA - GO_REF:0000033 $#ENSP00000384179#ENSG00000169946#ENST00000407775#C2H2 ZF Containing Proteins#$#ENSP00000428720#ENSG00000169946#ENST00000517361#C2H2 ZF Containing Proteins#zf-C2H2_4$#ENSP00000430757#ENSG00000169946#ENST00000520492#C2H2 ZF Containing Proteins#zf-C2H2_4$#ENSP00000428149#ENSG00000169946#ENST00000520027#C2H2 ZF Containing Proteins# FALSE 442 ENSG00000056097 ZFR C2H2 ZF No ssDNA/RNA binding Not a DNA binding protein No motif None None IPR003604;IPR006561;IPR007087;IPR015880 51663 zinc finger RNA binding protein [Source:HGNC Symbol;Acc:HGNC:17277] None Full not tested None None x No No No 5a, one of the source datasets predicts is as a TF Yimeng Yin Sam Lambert No None $#ENSP00000265069#ENSG00000056097#ENST00000265069#C2H2 ZF Containing Proteins#DZF, zf-C2H2_2, zf-C2H2_jaz, zf-met FALSE 443 ENSG00000105278 ZFR2 C2H2 ZF No ssDNA/RNA binding Not a DNA binding protein No motif None ZFR2 contains only RNA-binding zinc fingers IPR003604;IPR006561;IPR007087;IPR015880 23217 zinc finger RNA binding protein 2 [Source:HGNC Symbol;Acc:HGNC:29189] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Pratyush Das Sam Lambert No None $#ENSP00000388567#ENSG00000105278#ENST00000439086#C2H2 ZF Containing Proteins#$#ENSP00000467762#ENSG00000105278#ENST00000591712#C2H2 ZF Containing Proteins#$#ENSP00000262961#ENSG00000105278#ENST00000262961#C2H2 ZF Containing Proteins#DZF, zf-C2H2_2, zf-C2H2_jaz, zf-met$#ENSP00000468289#ENSG00000105278#ENST00000592398#C2H2 ZF Containing Proteins# FALSE 444 ENSG00000005889 ZFX C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain None IPR006794;IPR007087;IPR015880; 7543 zinc finger protein, X-linked [Source:HGNC Symbol;Acc:HGNC:12869] None DBD Yes None There is a ChIP-seq experiment that has yielded decent looking motif with CGCNNGGCCGCG-consensus PMID:18555785 a Yes No Yes 1a1, Direct HQ evidence Yimeng Yin Laura Campitelli Yes $#ENSG00000005889#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000368475#ENSG00000005889#ENST00000379177#C2H2 ZF Containing Proteins#Zfx_Zfy_act$#ENSP00000438233#ENSG00000005889#ENST00000539115#C2H2 ZF Containing Proteins#Zfx_Zfy_act$#ENSP00000416298#ENSG00000005889#ENST00000419690#C2H2 ZF Containing Proteins#$#ENSP00000411637#ENSG00000005889#ENST00000428571#C2H2 ZF Containing Proteins#Zfx_Zfy_act FALSE 445 ENSG00000067646 ZFY C2H2 ZF Yes Inferred motif Monomer or homomultimer In vivo/Misc source None None IPR006794;IPR007087;IPR015880; 7544 zinc finger protein, Y-linked [Source:HGNC Symbol;Acc:HGNC:12870] None Full not tested None None a Yes No Yes 1a2, Orthologous HQ evidence Laura Campitelli Arttu Jolma Yes $#ENSG00000067646#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000155093#ENSG00000067646#ENST00000155093#C2H2 ZF Containing Proteins#Zfx_Zfy_act$#ENSP00000393908#ENSG00000067646#ENST00000449237#C2H2 ZF Containing Proteins#Zfx_Zfy_act$#ENSP00000485605#ENSG00000067646#ENST00000625061#C2H2 ZF Containing Proteins#Zfx_Zfy_act$#ENSP00000388814#ENSG00000067646#ENST00000443793#C2H2 ZF Containing Proteins# FALSE 446 ENSG00000152977 ZIC1 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR007087;IPR015880 7545 Zic family member 1 [Source:HGNC Symbol;Acc:HGNC:12872] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:11038359 Yes 1a1, Direct HQ evidence Arttu Jolma Pratyush Das Yes $#ENSG00000152977#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000152977#GO:0003700#sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024 | TAS - PMID:8542595 $#ENSP00000282928#ENSG00000152977#ENST00000282928#C2H2 ZF Containing Proteins#$#ENSP00000419664#ENSG00000152977#ENST00000488404#C2H2 ZF Containing Proteins# FALSE 447 ENSG00000043355 ZIC2 C2H2 ZF Yes Known motif Monomer or homomultimer 100 perc ID - in vitro None None IPR007087;IPR015880 7546 Zic family member 2 [Source:HGNC Symbol;Acc:HGNC:12873] None DBD Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:11053430 Yes 1a1, Direct HQ evidence Arttu Jolma Laura Campitelli Yes $#ENSG00000043355#GO:0003700#sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024$#ENSG00000043355#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024 $#ENSP00000365514#ENSG00000043355#ENST00000376335#C2H2 ZF Containing Proteins# FALSE 448 ENSG00000156925 ZIC3 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR007087;IPR015880 7547 Zic family member 3 [Source:HGNC Symbol;Acc:HGNC:12874] None DBD and Full Yes None None b Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:11053430 Yes 1a1, Direct HQ evidence Pratyush Das Yimeng Yin Yes $#ENSG00000156925#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:17764085$#ENSG00000156925#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:17764085 $#ENSP00000287538#ENSG00000156925#ENST00000287538#C2H2 ZF Containing Proteins#$#ENSP00000359638#ENSG00000156925#ENST00000370606#C2H2 ZF Containing Proteins# FALSE 449 ENSG00000174963 ZIC4 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR007087;IPR015880 84107 Zic family member 4 [Source:HGNC Symbol;Acc:HGNC:20393] None DBD and Full not tested None None b Yes TF Gene Candidate_DNA-Binding: sequence-specific_Other_PMIDS:15338008;15465018 No 1a1, Direct HQ evidence Sam Lambert Arttu Jolma Yes None $#ENSP00000372553#ENSG00000174963#ENST00000383075#C2H2 ZF Containing Proteins#$#ENSP00000420627#ENSG00000174963#ENST00000462748#C2H2 ZF Containing Proteins#$#ENSP00000397695#ENSG00000174963#ENST00000425731#C2H2 ZF Containing Proteins#$#ENSP00000420775#ENSG00000174963#ENST00000473123#C2H2 ZF Containing Proteins#$#ENSP00000417855#ENSG00000174963#ENST00000484399#C2H2 ZF Containing Proteins#$#ENSP00000435509#ENSG00000174963#ENST00000525172#C2H2 ZF Containing Proteins# FALSE 450 ENSG00000139800 ZIC5 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR007087;IPR015880 85416 Zic family member 5 [Source:HGNC Symbol;Acc:HGNC:20322] None DBD Yes None None b Yes TF Gene Candidate_DNA-Binding: sequence-specific_DNA Binding_PMIDS:15465018;15136147;15465018 No 1a1, Direct HQ evidence Laura Campitelli Sam Lambert Yes None $#ENSP00000267294#ENSG00000139800#ENST00000267294#C2H2 ZF Containing Proteins# FALSE 451 ENSG00000171649 ZIK1 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 284307 zinc finger protein interacting with K protein 1 [Source:HGNC Symbol;Acc:HGNC:33104] None Full not tested None None b Yes TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:8910362 Yes 1a1, Direct HQ evidence Sam Lambert Pratyush Das Yes $#ENSG00000171649#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000303820#ENSG00000171649#ENST00000307468#C2H2 ZF Containing Proteins#$#ENSP00000472867#ENSG00000171649#ENST00000597850#C2H2 ZF Containing Proteins#KRAB$#ENSP00000468937#ENSG00000171649#ENST00000599456#C2H2 ZF Containing Proteins#$#ENSP00000438487#ENSG00000171649#ENST00000536878#C2H2 ZF Containing Proteins#KRAB$#ENSP00000472088#ENSG00000171649#ENST00000600053#C2H2 ZF Containing Proteins#KRAB TRUE 452 ENSG00000269699 ZIM2 C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect Binds GKGGSWST consensus with GTGGCAGT as the optimal site based on competition EMSA (PMID: 26692216). IPR001909;IPR007087;IPR015880; 23619 zinc finger imprinted 2 [Source:HGNC Symbol;Acc:HGNC:12875] None not tested not tested None TFs that are in CisBP but not in Vaquerizas set No Yes No Yes 1a1, Direct HQ evidence Sam Lambert Jussi Taipale Yes $#ENSG00000269699#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000472306#ENSG00000269699#ENST00000593711#C2H2 ZF Containing Proteins#KRAB$#ENSP00000470326#ENSG00000269699#ENST00000601070#C2H2 ZF Containing Proteins#KRAB$#ENSP00000469173#ENSG00000269699#ENST00000593931#C2H2 ZF Containing Proteins# TRUE 453 ENSG00000141946 ZIM3 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 114026 zinc finger imprinted 3 [Source:HGNC Symbol;Acc:HGNC:16366] None Full not tested None None b Yes No Yes 1a1, Direct HQ evidence Yimeng Yin Sam Lambert Yes $#ENSG00000141946#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000269834#ENSG00000141946#ENST00000269834#C2H2 ZF Containing Proteins#KRAB TRUE 454 ENSG00000106261 ZKSCAN1 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001909;IPR003309;IPR007087;IPR008916;IPR015880; 7586 zinc finger with KRAB and SCAN domains 1 [Source:HGNC Symbol;Acc:HGNC:13101] None Full Yes None None b Yes No Yes 1a1, Direct HQ evidence Yimeng Yin Pratyush Das Yes $#ENSG00000106261#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 | NAS - PMID:7557990 $#ENSP00000323148#ENSG00000106261#ENST00000324306#C2H2 ZF Containing Proteins#KRAB, SCAN$#ENSP00000409172#ENSG00000106261#ENST00000426572#C2H2 ZF Containing Proteins#KRAB, SCAN$#ENSP00000443508#ENSG00000106261#ENST00000535170#C2H2 ZF Containing Proteins#KRAB$#ENSP00000394445#ENSG00000106261#ENST00000432317#C2H2 ZF Containing Proteins#SCAN TRUE 455 ENSG00000155592 ZKSCAN2 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR003309;IPR007087;IPR008916;IPR015880; 342357 zinc finger with KRAB and SCAN domains 2 [Source:HGNC Symbol;Acc:HGNC:25677] None Full not tested None None b Yes No Yes 1a1, Direct HQ evidence Laura Campitelli Arttu Jolma Yes $#ENSG00000155592#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000331626#ENSG00000155592#ENST00000328086#C2H2 ZF Containing Proteins#KRAB, SCAN TRUE 456 ENSG00000189298 ZKSCAN3 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001909;IPR003309;IPR007087;IPR008916;IPR015880; 80317 zinc finger with KRAB and SCAN domains 3 [Source:HGNC Symbol;Acc:HGNC:13853] None Full not tested None The Cell paper has this under heretic symbol ZNF306 b Yes No Yes 1a1, Direct HQ evidence Laura Campitelli Jussi Taipale Yes $#ENSG00000189298#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:18940803$#ENSG00000189298#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:23434374 $#ENSP00000252211#ENSG00000189298#ENST00000252211#C2H2 ZF Containing Proteins#KRAB, SCAN$#ENSP00000366465#ENSG00000189298#ENST00000377255#C2H2 ZF Containing Proteins#KRAB, SCAN$#ENSP00000341883#ENSG00000189298#ENST00000341464#C2H2 ZF Containing Proteins#KRAB TRUE 457 ENSG00000187626 ZKSCAN4 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR001909;IPR003309;IPR007087;IPR008916;IPR015880; 387032 zinc finger with KRAB and SCAN domains 4 [Source:HGNC Symbol;Acc:HGNC:13854] None DBD and Full not tested None None b Yes No Yes 1a2, Orthologous HQ evidence Sam Lambert Pratyush Das Yes $#ENSG00000187626#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000366509#ENSG00000187626#ENST00000377294#C2H2 ZF Containing Proteins#KRAB, SCAN TRUE 458 ENSG00000196652 ZKSCAN5 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR003309;IPR007087;IPR008916;IPR015880; 23660 zinc finger with KRAB and SCAN domains 5 [Source:HGNC Symbol;Acc:HGNC:12867] None DBD and Full Yes None None b Yes No Yes 1a1, Direct HQ evidence Pratyush Das Yimeng Yin Yes $#ENSG00000196652#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 | NAS - PMID:10585779 $#ENSP00000322872#ENSG00000196652#ENST00000326775#C2H2 ZF Containing Proteins#KRAB, SCAN$#ENSP00000377725#ENSG00000196652#ENST00000394170#C2H2 ZF Containing Proteins#KRAB, SCAN$#ENSP00000392104#ENSG00000196652#ENST00000451158#C2H2 ZF Containing Proteins#KRAB, SCAN TRUE 459 ENSG00000196345 ZKSCAN7 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001909;IPR003309;IPR007087;IPR008916;IPR015880; 55888 zinc finger with KRAB and SCAN domains 7 [Source:HGNC Symbol;Acc:HGNC:12955] None DBD and Full not tested None None b Yes No Yes 4a, two or more datasets predict it as a TF Sam Lambert Laura Campitelli Yes $#ENSG00000196345#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002 $#ENSP00000273320#ENSG00000196345#ENST00000273320#C2H2 ZF Containing Proteins#KRAB, SCAN$#ENSP00000345404#ENSG00000196345#ENST00000341840#C2H2 ZF Containing Proteins#KRAB, SCAN$#ENSP00000416681#ENSG00000196345#ENST00000431636#C2H2 ZF Containing Proteins#KRAB, SCAN$#ENSP00000405034#ENSG00000196345#ENST00000447279#C2H2 ZF Containing Proteins#KRAB$#ENSP00000389243#ENSG00000196345#ENST00000419137#C2H2 ZF Containing Proteins#KRAB$#ENSP00000395524#ENSG00000196345#ENST00000426540#C2H2 ZF Containing Proteins#KRAB, SCAN TRUE 460 ENSG00000198315 ZKSCAN8 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains and a KRAB-domain IPR001909;IPR003309;IPR007087;IPR008916;IPR015880; 7745 zinc finger with KRAB and SCAN domains 8 [Source:HGNC Symbol;Acc:HGNC:12983] None DBD and Full not tested None None b Yes No Yes 4a, two or more datasets predict it as a TF Sam Lambert Arttu Jolma Yes $#ENSG00000198315#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000332750#ENSG00000198315#ENST00000330236#C2H2 ZF Containing Proteins#KRAB, SCAN, SPX$#ENSP00000402948#ENSG00000198315#ENST00000457389#C2H2 ZF Containing Proteins#KRAB, SCAN, SPX TRUE 461 ENSG00000166432 ZMAT1 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif Single C2H2 domain Possible RBP. IPR003604;IPR007087;IPR015880; 84460 Zinc finger matrin-type 1 [Source:HGNC Symbol;Acc:HGNC:29377] None not tested not tested None None x Yes No No 4a, two or more datasets predict it as a TF Jussi Taipale Pratyush Das No None $#ENSP00000361868#ENSG00000166432#ENST00000372782#C2H2 ZF Containing Proteins#zf-C2H2_jaz, zf-U1, zf-met$#ENSP00000437529#ENSG00000166432#ENST00000540921#C2H2 ZF Containing Proteins#zf-C2H2_jaz, zf-U1, zf-met FALSE 462 ENSG00000172667 ZMAT3 C2H2 ZF No ssDNA/RNA binding Not a DNA binding protein No motif None Protein binds RNA (PMID: 19805223 and PMID: 16844115). IPR003604;IPR015880;IPR022755; 64393 zinc finger matrin-type 3 [Source:HGNC Symbol;Acc:HGNC:29983] None DBD and Full not tested None None b No Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0 No 4a, two or more datasets predict it as a TF Arttu Jolma Laura Campitelli No None $#ENSP00000311221#ENSG00000172667#ENST00000311417#C2H2 ZF Containing Proteins#AKAP95, zf-C2H2_2, zf-C2H2_4, zf-C2H2_jaz, zf-U1, $#ENSP00000396506#ENSG00000172667#ENST00000432729#C2H2 ZF Containing Proteins#AKAP95, zf-C2H2_2, zf-C2H2_4, zf-C2H2_jaz, zf-U1, $#ENSP00000398920#ENSG00000172667#ENST00000414084#C2H2 ZF Containing Proteins#zf-C2H2_jaz, zf-U1, zf-met FALSE 463 ENSG00000165061 ZMAT4 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Possible RBP. IPR003604;IPR007087;IPR015880;IPR022755 79698 zinc finger matrin-type 4 [Source:HGNC Symbol;Acc:HGNC:25844] None not tested Yes None None c No No No 5a, one of the source datasets predicts is as a TF Yimeng Yin Jussi Taipale No None $#ENSP00000319785#ENSG00000165061#ENST00000315769#C2H2 ZF Containing Proteins#CTU2, DUF3449, zf-C2H2_2, zf-C2H2_4, zf-C2H2_jaz, $#ENSP00000297737#ENSG00000165061#ENST00000297737#C2H2 ZF Containing Proteins#DUF3449, zf-C2H2_2, zf-C2H2_4, zf-C2H2_jaz, zf-U1,$#ENSP00000428423#ENSG00000165061#ENST00000519406#C2H2 ZF Containing Proteins#zf-C2H2_2, zf-C2H2_jaz, zf-U1, zf-met FALSE 464 ENSG00000256223 ZNF10 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 7556 zinc finger protein 268 [Source:HGNC Symbol;Acc:HGNC:13061] None DBD and Full not tested None None a Yes No No 4a, two or more datasets predict it as a TF Pratyush Das Arttu Jolma Yes None $#ENSP00000248211#ENSG00000256223#ENST00000248211#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2$#ENSP00000384893#ENSG00000256223#ENST00000402932#C2H2 ZF Containing Proteins#KRAB$#ENSP00000393814#ENSG00000256223#ENST00000426665#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2$#ENSP00000445997#ENSG00000256223#ENST00000538918#C2H2 ZF Containing Proteins#KRAB$#ENSP00000438232#ENSG00000256223#ENST00000540609#C2H2 ZF Containing Proteins#KRAB TRUE 465 ENSG00000197020 ZNF100 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 163227 zinc finger protein 100 [Source:HGNC Symbol;Acc:HGNC:12880] None DBD and Full not tested None None b Yes No No 1a1, Direct HQ evidence Sam Lambert Arttu Jolma Yes None $#ENSP00000445201#ENSG00000197020#ENST00000305570#C2H2 ZF Containing Proteins#$#ENSP00000351042#ENSG00000197020#ENST00000358296#C2H2 ZF Containing Proteins#KRAB$#ENSP00000471371#ENSG00000197020#ENST00000594401#C2H2 ZF Containing Proteins#KRAB$#ENSP00000471057#ENSG00000197020#ENST00000598026#C2H2 ZF Containing Proteins#KRAB TRUE 466 ENSG00000181896 ZNF101 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 94039 zinc finger protein 101 [Source:HGNC Symbol;Acc:HGNC:12881] None Full not tested None None b Yes No No 1a1, Direct HQ evidence Jussi Taipale Yimeng Yin Yes None $#ENSP00000400952#ENSG00000181896#ENST00000415784#C2H2 ZF Containing Proteins#$#ENSP00000466697#ENSG00000181896#ENST00000444249#C2H2 ZF Containing Proteins#KRAB$#ENSP00000468049#ENSG00000181896#ENST00000592502#C2H2 ZF Containing Proteins#KRAB$#ENSP00000467112#ENSG00000181896#ENST00000541458#C2H2 ZF Containing Proteins#zf-H2C2_2 TRUE 467 ENSG00000103994 ZNF106 C2H2 ZF No Unlikely to be sequence specific TF Not a DNA binding protein No motif None C2H2 ZFs are not present in most isoforms; of which most contain WD40 repeats. Previous annotations (TFCat) suggest role as a cofactor (PMID: 15833274). IPR001680;IPR007087;IPR015880;IPR017986 64397 zinc finger protein 106 [Source:HGNC Symbol;Acc:HGNC:12886] None not tested not tested None None c No TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:15833274 No 4a, two or more datasets predict it as a TF Pratyush Das Sam Lambert No None $#ENSP00000263805#ENSG00000103994#ENST00000263805#C2H2 ZF Containing Proteins#ANAPC4_WD40, BBS2_Mid, WD40, WD40_like, zf-C2H2_ab$#ENSP00000456845#ENSG00000103994#ENST00000564754#C2H2 ZF Containing Proteins#zf-C2H2_2, zf-C2H2_4, zf-C2H2_jaz$#ENSP00000455674#ENSG00000103994#ENST00000565380#C2H2 ZF Containing Proteins#ANAPC4_WD40, BBS2_Mid, PQQ_3, WD40, WD40_like, zf-$#ENSP00000456604#ENSG00000103994#ENST00000565500#C2H2 ZF Containing Proteins#ANAPC4_WD40, BBS2_Mid, Nup160, PQQ_3, WD40, WD40_l$#ENSP00000457637#ENSG00000103994#ENST00000565611#C2H2 ZF Containing Proteins#ANAPC4_WD40, BBS2_Mid, Nup160, PQQ_3, WD40, WD40_l$#ENSP00000455049#ENSG00000103994#ENST00000565948#C2H2 ZF Containing Proteins#$#ENSP00000456191#ENSG00000103994#ENST00000569648#C2H2 ZF Containing Proteins#ANAPC4_WD40, PQQ, PQQ_3, Urease_beta, WD40, WD40_l FALSE 468 ENSG00000196247 ZNF107 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains and a KRAB-domain IPR001909;IPR007087;IPR015880; 51427 zinc finger protein 107 [Source:HGNC Symbol;Acc:HGNC:12887] None Full not tested None None b Yes No No 5a, one of the source datasets predicts is as a TF Pratyush Das Arttu Jolma Yes None $#ENSP00000343443#ENSG00000196247#ENST00000344930#C2H2 ZF Containing Proteins#zf-H2C2_2$#ENSP00000353234#ENSG00000196247#ENST00000360117#C2H2 ZF Containing Proteins#$#ENSP00000378789#ENSG00000196247#ENST00000395391#C2H2 ZF Containing Proteins#zf-H2C2_2$#ENSP00000483720#ENSG00000196247#ENST00000620827#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2 FALSE 469 ENSG00000062370 ZNF112 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Has a nice cassette of znfC2H2 domains and a KRAB-domain; virtually nothing is known about it. IPR001909;IPR007087;IPR015880; 7771 zinc finger protein 112 [Source:HGNC Symbol;Acc:HGNC:12892] None Full not tested None None b Yes No Yes 4a, two or more datasets predict it as a TF Jussi Taipale Arttu Jolma Yes $#ENSG00000062370#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000337081#ENSG00000062370#ENST00000337401#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2$#ENSP00000346305#ENSG00000062370#ENST00000354340#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2$#ENSP00000467994#ENSG00000062370#ENST00000588057#C2H2 ZF Containing Proteins#KRAB TRUE 470 ENSG00000178150 ZNF114 C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect None IPR001909;IPR007087;IPR015880; 163071 zinc finger protein 114 [Source:HGNC Symbol;Acc:HGNC:12894] None Full not tested None None b Yes No No 1a1, Direct HQ evidence Yimeng Yin Jussi Taipale Yes None $#ENSP00000318898#ENSG00000178150#ENST00000315849#C2H2 ZF Containing Proteins#KRAB$#ENSP00000469998#ENSG00000178150#ENST00000595607#C2H2 ZF Containing Proteins#KRAB$#ENSP00000471469#ENSG00000178150#ENST00000595408#C2H2 ZF Containing Proteins#KRAB TRUE 471 ENSG00000152926 ZNF117 C2H2 ZF Yes Inferred motif Monomer or homomultimer In vivo/Misc source None None IPR007087;IPR015880 51351 zinc finger protein 117 [Source:HGNC Symbol;Acc:HGNC:12897] None not tested not tested None None b Yes No Yes 2a2, orthologous lower confidence evidence Pratyush Das Arttu Jolma Yes $#ENSG00000152926#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:2023909 $#ENSP00000282869#ENSG00000152926#ENST00000282869#C2H2 ZF Containing Proteins#zf-C2H2_6$#ENSP00000479944#ENSG00000152926#ENST00000620222#C2H2 ZF Containing Proteins#zf-C2H2_6$#ENSP00000484825#ENSG00000152926#ENST00000610793#C2H2 ZF Containing Proteins#XPA_N FALSE 472 ENSG00000164631 ZNF12 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001909;IPR007087;IPR015880; 7559 zinc finger protein 12 [Source:HGNC Symbol;Acc:HGNC:12902] None DBD and Full not tested None None a Yes No Yes 1a1, Direct HQ evidence Arttu Jolma Pratyush Das No $#ENSG00000164631#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000384405#ENSG00000164631#ENST00000404360#C2H2 ZF Containing Proteins#$#ENSP00000385939#ENSG00000164631#ENST00000405858#C2H2 ZF Containing Proteins#KRAB$#ENSP00000344745#ENSG00000164631#ENST00000342651#C2H2 ZF Containing Proteins#KRAB$#ENSP00000378375#ENSG00000164631#ENST00000394917#C2H2 ZF Containing Proteins#KRAB TRUE 473 ENSG00000197961 ZNF121 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR007087;IPR015880 7675 zinc finger protein 121 [Source:HGNC Symbol;Acc:HGNC:12904] None DBD and Full not tested None None b Yes No Yes 1a1, Direct HQ evidence Jussi Taipale Arttu Jolma Yes $#ENSG00000197961#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000468643#ENSG00000197961#ENST00000586602#C2H2 ZF Containing Proteins#$#ENSP00000326967#ENSG00000197961#ENST00000320451#C2H2 ZF Containing Proteins#$#ENSP00000467838#ENSG00000197961#ENST00000591447#C2H2 ZF Containing Proteins#zf-H2C2_2 FALSE 474 ENSG00000196418 ZNF124 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 7678 zinc finger protein 124 [Source:HGNC Symbol;Acc:HGNC:12907] None Full not tested None None b Yes No No 1a1, Direct HQ evidence Yimeng Yin Laura Campitelli Yes None $#ENSP00000340749#ENSG00000196418#ENST00000340684#C2H2 ZF Containing Proteins#KRAB$#ENSP00000440365#ENSG00000196418#ENST00000543802#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2$#ENSP00000462445#ENSG00000196418#ENST00000472531#C2H2 ZF Containing Proteins#KRAB$#ENSP00000463191#ENSG00000196418#ENST00000491356#C2H2 ZF Containing Proteins#KRAB TRUE 475 ENSG00000172262 ZNF131 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Evidence for DNA binding (PMID: 20303951 ). IPR000210;IPR007087;IPR011333;IPR013069;IPR015880; 7690 zinc finger protein 131 [Source:HGNC Symbol;Acc:HGNC:12915] None DBD and Full not tested None None b Yes No Yes 4a, two or more datasets predict it as a TF Pratyush Das Yimeng Yin Yes $#ENSG00000172262#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000172262#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:7557990 $#ENSP00000422079#ENSG00000172262#ENST00000515326#C2H2 ZF Containing Proteins#BTB$#ENSP00000305804#ENSG00000172262#ENST00000306938#C2H2 ZF Containing Proteins#BTB, zf-C2H2_4$#ENSP00000426504#ENSG00000172262#ENST00000509156#C2H2 ZF Containing Proteins#BTB, zf-C2H2_4$#ENSP00000425722#ENSG00000172262#ENST00000509931#C2H2 ZF Containing Proteins#BTB FALSE 476 ENSG00000131849 ZNF132 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 7691 zinc finger protein 132 [Source:HGNC Symbol;Acc:HGNC:12916] None DBD and Full not tested None None b Yes No Yes 1a1, Direct HQ evidence Pratyush Das Arttu Jolma Yes $#ENSG00000131849#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:7557990 $#ENSP00000254166#ENSG00000131849#ENST00000254166#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2 TRUE 477 ENSG00000125846 ZNF133 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 7692 zinc finger protein 133 [Source:HGNC Symbol;Acc:HGNC:12917] None DBD and Full not tested None None b Yes No Yes 1a1, Direct HQ evidence Jussi Taipale Tim Hughes Yes $#ENSG00000125846#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:7557990, PMID:9278146 $#ENSP00000346090#ENSG00000125846#ENST00000316358#C2H2 ZF Containing Proteins#KRAB$#ENSP00000366899#ENSG00000125846#ENST00000377671#C2H2 ZF Containing Proteins#KRAB$#ENSP00000383945#ENSG00000125846#ENST00000401790#C2H2 ZF Containing Proteins#KRAB$#ENSP00000385279#ENSG00000125846#ENST00000402618#C2H2 ZF Containing Proteins#$#ENSP00000442978#ENSG00000125846#ENST00000538547#C2H2 ZF Containing Proteins#$#ENSP00000487315#ENSG00000125846#ENST00000628216#C2H2 ZF Containing Proteins#KRAB$#ENSP00000485741#ENSG00000125846#ENST00000630056#C2H2 ZF Containing Proteins#$#ENSP00000400897#ENSG00000125846#ENST00000396026#C2H2 ZF Containing Proteins#KRAB$#ENSP00000406638#ENSG00000125846#ENST00000425686#C2H2 ZF Containing Proteins#KRAB$#ENSP00000403835#ENSG00000125846#ENST00000434018#C2H2 ZF Containing Proteins#KRAB$#ENSP00000439427#ENSG00000125846#ENST00000535822#C2H2 ZF Containing Proteins# TRUE 478 ENSG00000213762 ZNF134 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR007087;IPR015880 7693 zinc finger protein 134 [Source:HGNC Symbol;Acc:HGNC:12918] None Full not tested None None b Yes No Yes 1a1, Direct HQ evidence Pratyush Das Arttu Jolma Yes $#ENSG00000213762#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:7557990 $#ENSP00000379464#ENSG00000213762#ENST00000396161#C2H2 ZF Containing Proteins#zf-C2H2_4, zf-H2C2_2$#ENSP00000472314#ENSG00000213762#ENST00000600344#C2H2 ZF Containing Proteins#Toxin_12$#ENSP00000469065#ENSG00000213762#ENST00000600883#C2H2 ZF Containing Proteins# FALSE 479 ENSG00000176293 ZNF135 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 7694 zinc finger protein 135 [Source:HGNC Symbol;Acc:HGNC:12919] None Full not tested None None b Yes No Yes 1a1, Direct HQ evidence Yimeng Yin Arttu Jolma Yes $#ENSG00000176293#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 | NAS - PMID:7557990 $#ENSP00000321406#ENSG00000176293#ENST00000313434#C2H2 ZF Containing Proteins#KRAB$#ENSP00000441410#ENSG00000176293#ENST00000401053#C2H2 ZF Containing Proteins#KRAB$#ENSP00000369437#ENSG00000176293#ENST00000359978#C2H2 ZF Containing Proteins#KRAB$#ENSP00000427691#ENSG00000176293#ENST00000506786#C2H2 ZF Containing Proteins#$#ENSP00000422074#ENSG00000176293#ENST00000511556#C2H2 ZF Containing Proteins#KRAB TRUE 480 ENSG00000196646 ZNF136 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 7695 zinc finger protein 136 [Source:HGNC Symbol;Acc:HGNC:12920] None DBD and Full not tested None None b Yes No No 1a1, Direct HQ evidence Sam Lambert Pratyush Das Yes None $#ENSP00000344162#ENSG00000196646#ENST00000343979#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2$#ENSP00000388759#ENSG00000196646#ENST00000439995#C2H2 ZF Containing Proteins#$#ENSP00000397176#ENSG00000196646#ENST00000418338#C2H2 ZF Containing Proteins#$#ENSP00000403707#ENSG00000196646#ENST00000425827#C2H2 ZF Containing Proteins# TRUE 481 ENSG00000197008 ZNF138 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR001909;IPR007087;IPR015880; 7697 Zinc finger protein 138 [Source:HGNC Symbol;Acc:HGNC:12922] None DBD and Full not tested None None b Yes No No 4a, two or more datasets predict it as a TF Sam Lambert Laura Campitelli Yes $#ENSG00000197008#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:7557990 $#ENSP00000399528#ENSG00000197008#ENST00000437743#C2H2 ZF Containing Proteins#KRAB$#ENSP00000407262#ENSG00000197008#ENST00000440155#C2H2 ZF Containing Proteins#KRAB$#ENSP00000415995#ENSG00000197008#ENST00000440598#C2H2 ZF Containing Proteins#KRAB$#ENSP00000419197#ENSG00000197008#ENST00000494380#C2H2 ZF Containing Proteins#KRAB FALSE 482 ENSG00000105708 ZNF14 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains IPR001909;IPR007087;IPR015880; 7561 zinc finger protein 14 [Source:HGNC Symbol;Acc:HGNC:12924] None not tested not tested None None a Yes No No 4a, two or more datasets predict it as a TF Arttu Jolma Yimeng Yin Yes None $#ENSP00000340514#ENSG00000105708#ENST00000344099#C2H2 ZF Containing Proteins#KRAB TRUE 483 ENSG00000196387 ZNF140 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001909;IPR007087;IPR015880; 7699 zinc finger protein 140 [Source:HGNC Symbol;Acc:HGNC:12925] None DBD and Full not tested None None b Yes No Yes 1a1, Direct HQ evidence Yimeng Yin Arttu Jolma Yes $#ENSG00000196387#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:7557990 $#ENSP00000347755#ENSG00000196387#ENST00000355557#C2H2 ZF Containing Proteins#KRAB$#ENSP00000415499#ENSG00000196387#ENST00000429434#C2H2 ZF Containing Proteins#KRAB$#ENSP00000415016#ENSG00000196387#ENST00000440550#C2H2 ZF Containing Proteins#KRAB$#ENSP00000445411#ENSG00000196387#ENST00000544426#C2H2 ZF Containing Proteins#$#ENSP00000444905#ENSG00000196387#ENST00000356456#C2H2 ZF Containing Proteins#KRAB$#ENSP00000389566#ENSG00000196387#ENST00000412146#C2H2 ZF Containing Proteins#KRAB TRUE 484 ENSG00000131127 ZNF141 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 7700 zinc finger protein 141 [Source:HGNC Symbol;Acc:HGNC:12926] None Full not tested None None b Yes No No 1a1, Direct HQ evidence Tim Hughes Laura Campitelli Yes None $#ENSP00000240499#ENSG00000131127#ENST00000240499#C2H2 ZF Containing Proteins#KRAB$#ENSP00000425799#ENSG00000131127#ENST00000512994#C2H2 ZF Containing Proteins#KRAB$#ENSP00000424403#ENSG00000131127#ENST00000505939#C2H2 ZF Containing Proteins#KRAB TRUE 485 ENSG00000115568 ZNF142 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR007087;IPR015880 7701 zinc finger protein 142 [Source:HGNC Symbol;Acc:HGNC:12927] None not tested not tested None None b Yes No No 4a, two or more datasets predict it as a TF Pratyush Das Sam Lambert Yes None $#ENSP00000408643#ENSG00000115568#ENST00000449707#C2H2 ZF Containing Proteins#zf-C2H2_4, zf-C2H2_6, zf-H2C2_2, zf-H2C2_5$#ENSP00000391599#ENSG00000115568#ENST00000432460#C2H2 ZF Containing Proteins#$#ENSP00000400424#ENSG00000115568#ENST00000450560#C2H2 ZF Containing Proteins# FALSE 486 ENSG00000166478 ZNF143 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR007087;IPR015880 7702 zinc finger protein 143 [Source:HGNC Symbol;Acc:HGNC:12928] None DBD not tested None None a Yes No No 1a1, Direct HQ evidence Jussi Taipale Laura Campitelli Yes None $#ENSP00000379847#ENSG00000166478#ENST00000396602#C2H2 ZF Containing Proteins#CopK$#ENSP00000432154#ENSG00000166478#ENST00000530463#C2H2 ZF Containing Proteins#CopK, FecR$#ENSP00000379843#ENSG00000166478#ENST00000396597#C2H2 ZF Containing Proteins#CopK$#ENSP00000409432#ENSG00000166478#ENST00000438144#C2H2 ZF Containing Proteins#CopK, FecR$#ENSP00000401493#ENSG00000166478#ENST00000447186#C2H2 ZF Containing Proteins# FALSE 487 ENSG00000167635 ZNF146 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR007087;IPR015880 7705 zinc finger protein 146 [Source:HGNC Symbol;Acc:HGNC:12931] None Full not tested None None a Yes No Yes 1a1, Direct HQ evidence Laura Campitelli Sam Lambert Yes $#ENSG00000167635#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000392095#ENSG00000167635#ENST00000443387#C2H2 ZF Containing Proteins#$#ENSP00000400391#ENSG00000167635#ENST00000456324#C2H2 ZF Containing Proteins# FALSE 488 ENSG00000163848 ZNF148 C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain None IPR007087;IPR015880 7707 zinc finger protein 148 [Source:HGNC Symbol;Acc:HGNC:12933] None DBD and Full not tested None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:8355710 Yes 2a1, Lower confidence direct evidence Yimeng Yin Laura Campitelli Yes $#ENSG00000163848#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:12771217 $#ENSP00000353863#ENSG00000163848#ENST00000360647#C2H2 ZF Containing Proteins#$#ENSP00000420102#ENSG00000163848#ENST00000468369#C2H2 ZF Containing Proteins#$#ENSP00000420335#ENSG00000163848#ENST00000484491#C2H2 ZF Containing Proteins#$#ENSP00000420448#ENSG00000163848#ENST00000485866#C2H2 ZF Containing Proteins#$#ENSP00000419322#ENSG00000163848#ENST00000492394#C2H2 ZF Containing Proteins# FALSE 489 ENSG00000179909 ZNF154 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 7710 zinc finger protein 154 [Source:HGNC Symbol;Acc:HGNC:12939] None not tested not tested None None b Yes No Yes 1a1, Direct HQ evidence Pratyush Das Arttu Jolma Yes $#ENSG00000179909#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 | NAS - PMID:7557990 $#ENSP00000421258#ENSG00000179909#ENST00000512439#C2H2 ZF Containing Proteins#KRAB TRUE 490 ENSG00000204920 ZNF155 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR001909;IPR007087;IPR015880; 7711 zinc finger protein 155 [Source:HGNC Symbol;Acc:HGNC:12940] None Full not tested None None b Yes No Yes 4a, two or more datasets predict it as a TF Yimeng Yin Jussi Taipale Yes $#ENSG00000204920#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:7557990 $#ENSP00000270014#ENSG00000204920#ENST00000270014#C2H2 ZF Containing Proteins#KRAB$#ENSP00000465691#ENSG00000204920#ENST00000590615#C2H2 ZF Containing Proteins#KRAB$#ENSP00000385163#ENSG00000204920#ENST00000407951#C2H2 ZF Containing Proteins#KRAB TRUE 491 ENSG00000147117 ZNF157 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 7712 zinc finger protein 157 [Source:HGNC Symbol;Acc:HGNC:12942] None not tested not tested None None a Yes No Yes 1a1, Direct HQ evidence Sam Lambert Laura Campitelli Yes $#ENSG00000147117#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:8586441 $#ENSP00000366273#ENSG00000147117#ENST00000377073#C2H2 ZF Containing Proteins#KRAB TRUE 492 ENSG00000170631 ZNF16 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR007087;IPR015880 7564 zinc finger protein 16 [Source:HGNC Symbol;Acc:HGNC:12947] None DBD and Full not tested None None a Yes No Yes 1a1, Direct HQ evidence Laura Campitelli Pratyush Das Yes $#ENSG00000170631#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000276816#ENSG00000170631#ENST00000276816#C2H2 ZF Containing Proteins#XPA_N, zf-C2H2_6$#ENSP00000378369#ENSG00000170631#ENST00000394909#C2H2 ZF Containing Proteins#XPA_N, zf-C2H2_6$#ENSP00000434321#ENSG00000170631#ENST00000532351#C2H2 ZF Containing Proteins#$#ENSP00000484504#ENSG00000170631#ENST00000611477#C2H2 ZF Containing Proteins#XPA_N, zf-C2H2_6 FALSE 493 ENSG00000170949 ZNF160 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains and a KRAB-domain IPR001909;IPR007087;IPR015880; 90338 zinc finger protein 160 [Source:HGNC Symbol;Acc:HGNC:12948] None DBD and Full not tested None None a Yes No No 4a, two or more datasets predict it as a TF Arttu Jolma Sam Lambert Yes None $#ENSP00000347273#ENSG00000170949#ENST00000355147#C2H2 ZF Containing Proteins#KRAB$#ENSP00000409597#ENSG00000170949#ENST00000418871#C2H2 ZF Containing Proteins#KRAB$#ENSP00000470961#ENSG00000170949#ENST00000599056#C2H2 ZF Containing Proteins#KRAB$#ENSP00000469393#ENSG00000170949#ENST00000599247#C2H2 ZF Containing Proteins#KRAB$#ENSP00000470573#ENSG00000170949#ENST00000601421#C2H2 ZF Containing Proteins#$#ENSP00000406201#ENSG00000170949#ENST00000429604#C2H2 ZF Containing Proteins#KRAB$#ENSP00000470305#ENSG00000170949#ENST00000601982#C2H2 ZF Containing Proteins#KRAB TRUE 494 ENSG00000197279 ZNF165 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains and a SCAN-domain and that it appears to be expressed commonly in urinary bladder cancers PMID: 25214475 IPR003309;IPR007087;IPR008916;IPR015880 7718 zinc finger protein 165 [Source:HGNC Symbol;Acc:HGNC:12953] None DBD and Full not tested None None b Yes No Yes 4a, two or more datasets predict it as a TF Arttu Jolma Pratyush Das Yes $#ENSG00000197279#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000366542#ENSG00000197279#ENST00000377325#C2H2 ZF Containing Proteins#SCAN FALSE 495 ENSG00000175787 ZNF169 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 169841 zinc finger protein 169 [Source:HGNC Symbol;Acc:HGNC:12957] None DBD and Full not tested None None b Yes No No 1a1, Direct HQ evidence Pratyush Das Yimeng Yin Yes None $#ENSP00000475038#ENSG00000175787#ENST00000480716#C2H2 ZF Containing Proteins#KRAB$#ENSP00000474608#ENSG00000175787#ENST00000481550#C2H2 ZF Containing Proteins#KRAB$#ENSP00000340711#ENSG00000175787#ENST00000340911#C2H2 ZF Containing Proteins#KRAB$#ENSP00000378792#ENSG00000175787#ENST00000395395#C2H2 ZF Containing Proteins#KRAB TRUE 496 ENSG00000186272 ZNF17 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 7565 zinc finger protein 17 [Source:HGNC Symbol;Acc:HGNC:12958] None not tested not tested None None b Yes No No 1a1, Direct HQ evidence Sam Lambert Arttu Jolma Yes None $#ENSP00000302455#ENSG00000186272#ENST00000307658#C2H2 ZF Containing Proteins#KRAB$#ENSP00000471905#ENSG00000186272#ENST00000601808#C2H2 ZF Containing Proteins#KRAB$#ENSP00000472791#ENSG00000186272#ENST00000597350#C2H2 ZF Containing Proteins#KRAB TRUE 497 ENSG00000103343 ZNF174 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR003309;IPR007087;IPR008916;IPR015880 7727 zinc finger protein 174 [Source:HGNC Symbol;Acc:HGNC:12963] None DBD and Full not tested None None a Yes No Yes 1a1, Direct HQ evidence Laura Campitelli Tim Hughes Yes $#ENSG00000103343#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000103343#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:7673192 $#ENSP00000268655#ENSG00000103343#ENST00000268655#C2H2 ZF Containing Proteins#SCAN$#ENSP00000339781#ENSG00000103343#ENST00000344823#C2H2 ZF Containing Proteins#SCAN$#ENSP00000459681#ENSG00000103343#ENST00000572544#C2H2 ZF Containing Proteins#SCAN FALSE 498 ENSG00000105497 ZNF175 C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect None IPR001909;IPR007087;IPR015880; 7728 zinc finger protein 175 [Source:HGNC Symbol;Acc:HGNC:12964] None Full not tested None None a Yes No Yes 1a1, Direct HQ evidence Yimeng Yin Laura Campitelli Yes $#ENSG00000105497#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:8838321 $#ENSP00000262259#ENSG00000105497#ENST00000262259#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2$#ENSP00000444424#ENSG00000105497#ENST00000545217#C2H2 ZF Containing Proteins#$#ENSP00000440578#ENSG00000105497#ENST00000436511#C2H2 ZF Containing Proteins#KRAB$#ENSP00000470922#ENSG00000105497#ENST00000596504#C2H2 ZF Containing Proteins#KRAB TRUE 499 ENSG00000188629 ZNF177 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001909;IPR007087;IPR015880; 7730 zinc finger protein 177 [Source:HGNC Symbol;Acc:HGNC:12966] None DBD and Full not tested None None b Yes No No 1a1, Direct HQ evidence Laura Campitelli Yimeng Yin Yes None $#ENSP00000341497#ENSG00000188629#ENST00000343499#C2H2 ZF Containing Proteins#KRAB$#ENSP00000468531#ENSG00000188629#ENST00000589262#C2H2 ZF Containing Proteins#KRAB$#ENSP00000465438#ENSG00000188629#ENST00000590616#C2H2 ZF Containing Proteins#KRAB$#ENSP00000467978#ENSG00000188629#ENST00000592912#C2H2 ZF Containing Proteins# TRUE 500 ENSG00000154957 ZNF18 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR003309;IPR007087;IPR008916;IPR015880; 7566 zinc finger protein 18 [Source:HGNC Symbol;Acc:HGNC:12969] None DBD and Full not tested None None b Yes No Yes 1a1, Direct HQ evidence Laura Campitelli Sam Lambert Yes $#ENSG00000154957#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000391376#ENSG00000154957#ENST00000454073#C2H2 ZF Containing Proteins#KRAB, SCAN$#ENSP00000462296#ENSG00000154957#ENST00000580613#C2H2 ZF Containing Proteins#KRAB, SCAN$#ENSP00000315664#ENSG00000154957#ENST00000322748#C2H2 ZF Containing Proteins#KRAB, SCAN$#ENSP00000463471#ENSG00000154957#ENST00000580306#C2H2 ZF Containing Proteins#KRAB, SCAN$#ENSP00000462383#ENSG00000154957#ENST00000577671#C2H2 ZF Containing Proteins#KRAB$#ENSP00000462416#ENSG00000154957#ENST00000580903#C2H2 ZF Containing Proteins#SCAN$#ENSP00000462877#ENSG00000154957#ENST00000582607#C2H2 ZF Containing Proteins#KRAB TRUE 501 ENSG00000167384 ZNF180 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 7733 Zinc finger protein 180 [Source:HGNC Symbol;Acc:HGNC:12970] None Full not tested None None a Yes No No 1a1, Direct HQ evidence Laura Campitelli Yimeng Yin Yes None $#ENSP00000221327#ENSG00000167384#ENST00000221327#C2H2 ZF Containing Proteins#KRAB$#ENSP00000375818#ENSG00000167384#ENST00000391956#C2H2 ZF Containing Proteins#KRAB$#ENSP00000468021#ENSG00000167384#ENST00000592529#C2H2 ZF Containing Proteins#KRAB$#ENSP00000467916#ENSG00000167384#ENST00000591064#C2H2 ZF Containing Proteins#KRAB TRUE 502 ENSG00000197841 ZNF181 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR003656;IPR007087;IPR015880 339318 zinc finger protein 181 [Source:HGNC Symbol;Acc:HGNC:12971] None DBD and Full not tested None None a Yes No No 1a1, Direct HQ evidence Sam Lambert Arttu Jolma Yes None $#ENSP00000419435#ENSG00000197841#ENST00000459757#C2H2 ZF Containing Proteins#KRAB$#ENSP00000420727#ENSG00000197841#ENST00000492450#C2H2 ZF Containing Proteins#KRAB$#ENSP00000473016#ENSG00000197841#ENST00000595708#C2H2 ZF Containing Proteins#KRAB$#ENSP00000471063#ENSG00000197841#ENST00000593781#C2H2 ZF Containing Proteins#KRAB$#ENSP00000472046#ENSG00000197841#ENST00000599244#C2H2 ZF Containing Proteins#KRAB TRUE 503 ENSG00000147118 ZNF182 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 7569 zinc finger protein 182 [Source:HGNC Symbol;Acc:HGNC:13001] None Full not tested None None a Yes No Yes 1a1, Direct HQ evidence Pratyush Das Yimeng Yin Yes $#ENSG00000147118#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000366142#ENSG00000147118#ENST00000376943#C2H2 ZF Containing Proteins#KRAB$#ENSP00000380165#ENSG00000147118#ENST00000396965#C2H2 ZF Containing Proteins#KRAB TRUE 504 ENSG00000096654 ZNF184 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 7738 zinc finger protein 184 [Source:HGNC Symbol;Acc:HGNC:12975] None DBD and Full not tested None None b Yes No No 1a1, Direct HQ evidence Jussi Taipale Pratyush Das Yes None $#ENSP00000211936#ENSG00000096654#ENST00000211936#C2H2 ZF Containing Proteins#KRAB$#ENSP00000366636#ENSG00000096654#ENST00000377419#C2H2 ZF Containing Proteins#KRAB TRUE 505 ENSG00000136870 ZNF189 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 7743 zinc finger protein 189 [Source:HGNC Symbol;Acc:HGNC:12980] None DBD and Full not tested None None b Yes No Yes 1a1, Direct HQ evidence Pratyush Das Arttu Jolma Yes $#ENSG00000136870#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:9653648 $#ENSP00000259395#ENSG00000136870#ENST00000259395#C2H2 ZF Containing Proteins#$#ENSP00000342019#ENSG00000136870#ENST00000339664#C2H2 ZF Containing Proteins#KRAB$#ENSP00000363995#ENSG00000136870#ENST00000374861#C2H2 ZF Containing Proteins#KRAB$#ENSP00000483461#ENSG00000136870#ENST00000615466#C2H2 ZF Containing Proteins#KRAB TRUE 506 ENSG00000157429 ZNF19 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 7567 zinc finger protein 19 [Source:HGNC Symbol;Acc:HGNC:12981] None Full not tested None None a Yes No Yes 1a1, Direct HQ evidence Sam Lambert Jussi Taipale Yes $#ENSG00000157429#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:7557990 $#ENSP00000288177#ENSG00000157429#ENST00000288177#C2H2 ZF Containing Proteins#KRAB$#ENSP00000455575#ENSG00000157429#ENST00000564225#C2H2 ZF Containing Proteins#KRAB$#ENSP00000458105#ENSG00000157429#ENST00000564230#C2H2 ZF Containing Proteins#KRAB$#ENSP00000454864#ENSG00000157429#ENST00000565637#C2H2 ZF Containing Proteins#$#ENSP00000462021#ENSG00000157429#ENST00000561469#C2H2 ZF Containing Proteins#KRAB$#ENSP00000462566#ENSG00000157429#ENST00000567225#C2H2 ZF Containing Proteins#KRAB TRUE 507 ENSG00000005801 ZNF195 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Kruppel family C2H2 ZF. IPR001909;IPR007087;IPR015880; 7748 zinc finger protein 195 [Source:HGNC Symbol;Acc:HGNC:12986] None Full Yes None None b Yes No No 4a, two or more datasets predict it as a TF Jussi Taipale Sam Lambert Yes None $#ENSP00000005082#ENSG00000005801#ENST00000005082#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2$#ENSP00000346613#ENSG00000005801#ENST00000354599#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2$#ENSP00000382511#ENSG00000005801#ENST00000399602#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2$#ENSP00000431937#ENSG00000005801#ENST00000528410#C2H2 ZF Containing Proteins#KRAB, zf-C2H2_6, zf-H2C2_2$#ENSP00000435828#ENSG00000005801#ENST00000526601#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2$#ENSP00000414353#ENSG00000005801#ENST00000438262#C2H2 ZF Containing Proteins#KRAB$#ENSP00000433911#ENSG00000005801#ENST00000533036#C2H2 ZF Containing Proteins#KRAB$#ENSP00000437265#ENSG00000005801#ENST00000534569#C2H2 ZF Containing Proteins#KRAB TRUE 508 ENSG00000186448 ZNF197 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR003309;IPR007087;IPR008916;IPR015880; 10168 zinc finger protein 197 [Source:HGNC Symbol;Acc:HGNC:12988] None DBD not tested None None a Yes No Yes 1a1, Direct HQ evidence Jussi Taipale Arttu Jolma Yes $#ENSG00000186448#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002 $#ENSP00000345809#ENSG00000186448#ENST00000344387#C2H2 ZF Containing Proteins#KRAB, SCAN$#ENSP00000373250#ENSG00000186448#ENST00000383744#C2H2 ZF Containing Proteins#KRAB, SCAN$#ENSP00000373251#ENSG00000186448#ENST00000383745#C2H2 ZF Containing Proteins#KRAB, SCAN$#ENSP00000379370#ENSG00000186448#ENST00000396058#C2H2 ZF Containing Proteins#KRAB, SCAN$#ENSP00000394713#ENSG00000186448#ENST00000412641#C2H2 ZF Containing Proteins#SCAN TRUE 509 ENSG00000275111 ZNF2 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 7549 zinc finger protein 2 [Source:HGNC Symbol;Acc:HGNC:12991] None DBD and Full not tested None None a Yes No No 4a, two or more datasets predict it as a TF Jussi Taipale Yimeng Yin Yes $#ENSG00000275111#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000477960#ENSG00000275111#ENST00000611463#C2H2 ZF Containing Proteins#$#ENSP00000480297#ENSG00000275111#ENST00000614034#C2H2 ZF Containing Proteins#KRAB$#ENSP00000480057#ENSG00000275111#ENST00000617923#C2H2 ZF Containing Proteins#$#ENSP00000482030#ENSG00000275111#ENST00000611147#C2H2 ZF Containing Proteins#KRAB$#ENSP00000483131#ENSG00000275111#ENST00000622059#C2H2 ZF Containing Proteins#KRAB TRUE 510 ENSG00000132010 ZNF20 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR001909;IPR007087;IPR015880; 7568 zinc finger protein 20 [Source:HGNC Symbol;Acc:HGNC:12992] None DBD and Full not tested None None b Yes No No 4a, two or more datasets predict it as a TF Laura Campitelli Pratyush Das Yes None $#ENSP00000335437#ENSG00000132010#ENST00000334213#C2H2 ZF Containing Proteins#KRAB$#ENSP00000390115#ENSG00000132010#ENST00000418866#C2H2 ZF Containing Proteins#KRAB$#ENSP00000470025#ENSG00000132010#ENST00000600335#C2H2 ZF Containing Proteins#KRAB TRUE 511 ENSG00000010539 ZNF200 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR007087;IPR015880 7752 zinc finger protein 200 [Source:HGNC Symbol;Acc:HGNC:12993] None DBD and Full not tested None None a Yes No Yes 1a1, Direct HQ evidence Jussi Taipale Sam Lambert Yes $#ENSG00000010539#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000380077#ENSG00000010539#ENST00000396868#C2H2 ZF Containing Proteins#KRAB$#ENSP00000380079#ENSG00000010539#ENST00000396870#C2H2 ZF Containing Proteins#KRAB$#ENSP00000380080#ENSG00000010539#ENST00000396871#C2H2 ZF Containing Proteins#KRAB$#ENSP00000405786#ENSG00000010539#ENST00000414144#C2H2 ZF Containing Proteins#KRAB$#ENSP00000395723#ENSG00000010539#ENST00000431561#C2H2 ZF Containing Proteins#KRAB$#ENSP00000458508#ENSG00000010539#ENST00000575948#C2H2 ZF Containing Proteins#KRAB$#ENSP00000458777#ENSG00000010539#ENST00000575617#C2H2 ZF Containing Proteins# FALSE 512 ENSG00000166261 ZNF202 C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect None IPR001909;IPR003309;IPR007087;IPR008916;IPR015880; 7753 zinc finger protein 202 [Source:HGNC Symbol;Acc:HGNC:12994] None DBD and Full not tested None None a Yes No Yes 1a1, Direct HQ evidence Sam Lambert Pratyush Das Yes $#ENSG00000166261#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000166261#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:10748193, PMID:9790754 $#ENSP00000337724#ENSG00000166261#ENST00000336139#C2H2 ZF Containing Proteins#KRAB, SCAN$#ENSP00000432504#ENSG00000166261#ENST00000530393#C2H2 ZF Containing Proteins#KRAB, SCAN$#ENSP00000433881#ENSG00000166261#ENST00000529691#C2H2 ZF Containing Proteins#KRAB, SCAN$#ENSP00000431223#ENSG00000166261#ENST00000533463#C2H2 ZF Containing Proteins#SCAN TRUE 513 ENSG00000122386 ZNF205 C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect None IPR001909;IPR007087;IPR015880; 7755 zinc finger protein 205 [Source:HGNC Symbol;Acc:HGNC:12996] None DBD and Full not tested None None a Yes No Yes 1a1, Direct HQ evidence Sam Lambert Yimeng Yin Yes $#ENSG00000122386#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000371627#ENSG00000122386#ENST00000382192#C2H2 ZF Containing Proteins#KRAB$#ENSP00000480401#ENSG00000122386#ENST00000620094#C2H2 ZF Containing Proteins#KRAB$#ENSP00000403306#ENSG00000122386#ENST00000414351#C2H2 ZF Containing Proteins#KRAB$#ENSP00000394360#ENSG00000122386#ENST00000444510#C2H2 ZF Containing Proteins# TRUE 514 ENSG00000010244 ZNF207 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR007087;IPR015880 693217 zinc finger protein 207 [Source:HGNC Symbol;Acc:HGNC:12998] None DBD and Full not tested None None b No No Yes 4a, two or more datasets predict it as a TF Pratyush Das Jussi Taipale No $#ENSG00000010244#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:9799612 $#ENSP00000322777#ENSG00000010244#ENST00000321233#C2H2 ZF Containing Proteins#$#ENSP00000378165#ENSG00000010244#ENST00000394670#C2H2 ZF Containing Proteins#$#ENSP00000378168#ENSG00000010244#ENST00000394673#C2H2 ZF Containing Proteins#$#ENSP00000378172#ENSG00000010244#ENST00000394679#C2H2 ZF Containing Proteins#$#ENSP00000463040#ENSG00000010244#ENST00000579634#C2H2 ZF Containing Proteins# FALSE 515 ENSG00000160321 ZNF208 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR001909;IPR007087;IPR015880; 7757 zinc finger protein 208 [Source:HGNC Symbol;Acc:HGNC:12999] None not tested not tested None None b Yes No No 4a, two or more datasets predict it as a TF Jussi Taipale Sam Lambert Yes None $#ENSP00000469254#ENSG00000160321#ENST00000599916#C2H2 ZF Containing Proteins#KRAB$#ENSP00000472406#ENSG00000160321#ENST00000597040#C2H2 ZF Containing Proteins#KRAB$#ENSP00000469887#ENSG00000160321#ENST00000601773#C2H2 ZF Containing Proteins#KRAB$#ENSP00000380315#ENSG00000160321#ENST00000397126#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2$#ENSP00000473026#ENSG00000160321#ENST00000599723#C2H2 ZF Containing Proteins#KRAB TRUE 516 ENSG00000121417 ZNF211 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 10520 zinc finger protein 211 [Source:HGNC Symbol;Acc:HGNC:13003] None Full not tested None None b Yes No Yes 1a1, Direct HQ evidence Laura Campitelli Pratyush Das Yes $#ENSG00000121417#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000339562#ENSG00000121417#ENST00000347302#C2H2 ZF Containing Proteins#KRAB$#ENSP00000384436#ENSG00000121417#ENST00000407202#C2H2 ZF Containing Proteins#KRAB$#ENSP00000240731#ENSG00000121417#ENST00000240731#C2H2 ZF Containing Proteins#KRAB$#ENSP00000254182#ENSG00000121417#ENST00000254182#C2H2 ZF Containing Proteins#$#ENSP00000375584#ENSG00000121417#ENST00000391703#C2H2 ZF Containing Proteins#$#ENSP00000299871#ENSG00000121417#ENST00000299871#C2H2 ZF Containing Proteins#KRAB$#ENSP00000442601#ENSG00000121417#ENST00000541801#C2H2 ZF Containing Proteins#KRAB TRUE 517 ENSG00000170260 ZNF212 C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect None IPR001909;IPR007087;IPR015880;IPR022137 7988 zinc finger protein 212 [Source:HGNC Symbol;Acc:HGNC:13004] None DBD and Full not tested None None b Yes No No 1a1, Direct HQ evidence Arttu Jolma Laura Campitelli Yes None $#ENSP00000338572#ENSG00000170260#ENST00000335870#C2H2 ZF Containing Proteins#DUF3669, KRAB, zf-C2H2_4, zf-C2H2_6, zf-C2HC_2, zf$#ENSP00000419419#ENSG00000170260#ENST00000481584#C2H2 ZF Containing Proteins#KRAB TRUE 518 ENSG00000085644 ZNF213 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE); Has a putative AT-hook None IPR001909;IPR003309;IPR007087;IPR008916;IPR015880; 7760 zinc finger protein 213 [Source:HGNC Symbol;Acc:HGNC:13005] None DBD and Full not tested None None b Yes No Yes 1a1, Direct HQ evidence Laura Campitelli Jussi Taipale Yes $#ENSG00000085644#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000380087#ENSG00000085644#ENST00000396878#C2H2 ZF Containing Proteins#KRAB, SCAN$#ENSP00000459233#ENSG00000085644#ENST00000572647#C2H2 ZF Containing Proteins#SCAN$#ENSP00000459177#ENSG00000085644#ENST00000576416#C2H2 ZF Containing Proteins#KRAB, SCAN$#ENSP00000459293#ENSG00000085644#ENST00000574575#C2H2 ZF Containing Proteins# TRUE 519 ENSG00000149050 ZNF214 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 7761 zinc finger protein 214 [Source:HGNC Symbol;Acc:HGNC:13006] None Full not tested None None b Yes No No 1a1, Direct HQ evidence Sam Lambert Pratyush Das Yes None $#ENSP00000278314#ENSG00000149050#ENST00000278314#C2H2 ZF Containing Proteins#KRAB$#ENSP00000445373#ENSG00000149050#ENST00000536068#C2H2 ZF Containing Proteins#KRAB TRUE 520 ENSG00000149054 ZNF215 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR001909;IPR003309;IPR007087;IPR008916;IPR015880; 7762 zinc finger protein 215 [Source:HGNC Symbol;Acc:HGNC:13007] None DBD and Full not tested None None a Yes No Yes 4a, two or more datasets predict it as a TF Pratyush Das Sam Lambert Yes $#ENSG00000149054#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 | NAS - PMID:10762538 $#ENSP00000278319#ENSG00000149054#ENST00000278319#C2H2 ZF Containing Proteins#KRAB, SCAN$#ENSP00000432306#ENSG00000149054#ENST00000529903#C2H2 ZF Containing Proteins#KRAB, SCAN$#ENSP00000393202#ENSG00000149054#ENST00000414517#C2H2 ZF Containing Proteins#KRAB, SCAN$#ENSP00000484674#ENSG00000149054#ENST00000610573#C2H2 ZF Containing Proteins#KRAB, SCAN TRUE 521 ENSG00000171940 ZNF217 C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain Based on (PDB: 3UK3) this protein has at least two DNA binding znf domains. In vitro evidence for DNA binding (PMID:17130829). IPR007087;IPR015880 7764 zinc finger protein 217 [Source:HGNC Symbol;Acc:HGNC:13009] 3UK3 DBD and Full not tested None Crystal has two single znfC2H2 domains b Yes No Yes 1a1, Direct HQ evidence Sam Lambert Pratyush Das Yes $#ENSG00000171940#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:17130829$#ENSG00000171940#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:9671742 $#ENSP00000304308#ENSG00000171940#ENST00000302342#C2H2 ZF Containing Proteins#$#ENSP00000394010#ENSG00000171940#ENST00000437222#C2H2 ZF Containing Proteins#$#ENSP00000360526#ENSG00000171940#ENST00000371471#C2H2 ZF Containing Proteins#$#ENSP00000399672#ENSG00000171940#ENST00000431687#C2H2 ZF Containing Proteins# FALSE 522 ENSG00000165804 ZNF219 C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain Binds CCCCCA based on SELEX (PMID: 14621294). IPR003980;IPR007087;IPR015880; 51222 zinc finger protein 219 [Source:HGNC Symbol;Acc:HGNC:13011] None DBD and Full not tested None None b Yes No Yes 2a1, Lower confidence direct evidence Arttu Jolma Laura Campitelli Yes $#ENSG00000165804#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:14621294$#ENSG00000165804#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:14621294, PMID:19549071 $#ENSP00000354206#ENSG00000165804#ENST00000360947#C2H2 ZF Containing Proteins#zf-H2C2_5$#ENSP00000392401#ENSG00000165804#ENST00000421093#C2H2 ZF Containing Proteins#zf-H2C2_5$#ENSP00000450900#ENSG00000165804#ENST00000553296#C2H2 ZF Containing Proteins#$#ENSP00000451595#ENSG00000165804#ENST00000555697#C2H2 ZF Containing Proteins# FALSE 523 ENSG00000165512 ZNF22 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR007087;IPR015880 7570 zinc finger protein 22 [Source:HGNC Symbol;Acc:HGNC:13012] None DBD and Full Yes None None a Yes TF Gene Candidate__DNA Binding_PMIDS:12952191 No 1a1, Direct HQ evidence Sam Lambert Laura Campitelli Yes None $#ENSP00000298299#ENSG00000165512#ENST00000298299#C2H2 ZF Containing Proteins# FALSE 524 ENSG00000159905 ZNF221 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR001909;IPR007087;IPR015880; 7638 Zinc finger protein 221 [Source:HGNC Symbol;Acc:HGNC:13014] None DBD and Full not tested None None b Yes No No 4a, two or more datasets predict it as a TF Pratyush Das Sam Lambert Yes $#ENSG00000159905#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000251269#ENSG00000159905#ENST00000251269#C2H2 ZF Containing Proteins#KRAB$#ENSP00000467367#ENSG00000159905#ENST00000587682#C2H2 ZF Containing Proteins#KRAB$#ENSP00000467446#ENSG00000159905#ENST00000592350#C2H2 ZF Containing Proteins#KRAB$#ENSP00000477876#ENSG00000159905#ENST00000622072#C2H2 ZF Containing Proteins#KRAB$#ENSP00000464885#ENSG00000159905#ENST00000591168#C2H2 ZF Containing Proteins#KRAB FALSE 525 ENSG00000159885 ZNF222 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 7673 zinc finger protein 222 [Source:HGNC Symbol;Acc:HGNC:13015] None DBD not tested None None b Yes No No 1a1, Direct HQ evidence Sam Lambert Yimeng Yin Yes None $#ENSP00000187879#ENSG00000159885#ENST00000187879#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2$#ENSP00000375822#ENSG00000159885#ENST00000391960#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2$#ENSP00000466778#ENSG00000159885#ENST00000587846#C2H2 ZF Containing Proteins#KRAB TRUE 526 ENSG00000178386 ZNF223 C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect None IPR001909;IPR007087;IPR015880; 7766 zinc finger protein 223 [Source:HGNC Symbol;Acc:HGNC:13016] None DBD and Full not tested None None b Yes No Yes 1a1, Direct HQ evidence Sam Lambert Arttu Jolma Yes $#ENSG00000178386#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000401947#ENSG00000178386#ENST00000434772#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2$#ENSP00000467647#ENSG00000178386#ENST00000591850#C2H2 ZF Containing Proteins#$#ENSP00000467561#ENSG00000178386#ENST00000585552#C2H2 ZF Containing Proteins#KRAB TRUE 527 ENSG00000267680 ZNF224 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 7767 zinc finger protein 224 [Source:HGNC Symbol;Acc:HGNC:13017] None DBD and Full not tested None None b Yes No Yes 4a, two or more datasets predict it as a TF Arttu Jolma Pratyush Das Yes $#ENSG00000267680#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000337368#ENSG00000267680#ENST00000336976#C2H2 ZF Containing Proteins#KRAB$#ENSP00000466961#ENSG00000267680#ENST00000591511#C2H2 ZF Containing Proteins#KRAB$#ENSP00000465000#ENSG00000267680#ENST00000589680#C2H2 ZF Containing Proteins#KRAB$#ENSP00000465886#ENSG00000267680#ENST00000589870#C2H2 ZF Containing Proteins#KRAB TRUE 528 ENSG00000256294 ZNF225 C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect None IPR001909;IPR007087;IPR015880; 7768 zinc finger protein 225 [Source:HGNC Symbol;Acc:HGNC:13018] None Full not tested None None b Yes No Yes 4a, two or more datasets predict it as a TF Jussi Taipale Yimeng Yin Yes $#ENSG00000256294#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000262894#ENSG00000256294#ENST00000262894#C2H2 ZF Containing Proteins#KRAB$#ENSP00000468686#ENSG00000256294#ENST00000590612#C2H2 ZF Containing Proteins#KRAB$#ENSP00000468414#ENSG00000256294#ENST00000588926#C2H2 ZF Containing Proteins#KRAB$#ENSP00000466853#ENSG00000256294#ENST00000589155#C2H2 ZF Containing Proteins#KRAB TRUE 529 ENSG00000167380 ZNF226 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR001909;IPR007087;IPR015880; 7769 zinc finger protein 226 [Source:HGNC Symbol;Acc:HGNC:13019] None Full not tested None None b Yes No Yes 4a, two or more datasets predict it as a TF Jussi Taipale Yimeng Yin Yes $#ENSG00000167380#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000300823#ENSG00000167380#ENST00000300823#C2H2 ZF Containing Proteins#KRAB$#ENSP00000336719#ENSG00000167380#ENST00000337433#C2H2 ZF Containing Proteins#KRAB$#ENSP00000393265#ENSG00000167380#ENST00000454662#C2H2 ZF Containing Proteins#KRAB$#ENSP00000467003#ENSG00000167380#ENST00000588742#C2H2 ZF Containing Proteins#KRAB$#ENSP00000464735#ENSG00000167380#ENST00000588795#C2H2 ZF Containing Proteins#KRAB$#ENSP00000465401#ENSG00000167380#ENST00000588883#C2H2 ZF Containing Proteins#KRAB$#ENSP00000465121#ENSG00000167380#ENST00000590089#C2H2 ZF Containing Proteins#KRAB$#ENSP00000468779#ENSG00000167380#ENST00000590578#C2H2 ZF Containing Proteins#KRAB$#ENSP00000407474#ENSG00000167380#ENST00000413984#C2H2 ZF Containing Proteins#KRAB$#ENSP00000467766#ENSG00000167380#ENST00000590524#C2H2 ZF Containing Proteins#KRAB TRUE 530 ENSG00000131115 ZNF227 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR001909;IPR007087;IPR015880; 7770 zinc finger protein 227 [Source:HGNC Symbol;Acc:HGNC:13020] None DBD and Full not tested None None b Yes No Yes 4a, two or more datasets predict it as a TF Jussi Taipale Tim Hughes Yes $#ENSG00000131115#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000321049#ENSG00000131115#ENST00000313040#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2$#ENSP00000467496#ENSG00000131115#ENST00000586228#C2H2 ZF Containing Proteins#$#ENSP00000464866#ENSG00000131115#ENST00000588219#C2H2 ZF Containing Proteins#$#ENSP00000467577#ENSG00000131115#ENST00000589005#C2H2 ZF Containing Proteins#zf-H2C2_2$#ENSP00000482749#ENSG00000131115#ENST00000621083#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2$#ENSP00000464800#ENSG00000131115#ENST00000586048#C2H2 ZF Containing Proteins#KRAB TRUE 531 ENSG00000278318 ZNF229 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains and a KRAB-domain IPR001909;IPR007087;IPR015880; 7772 Zinc finger protein 229 [Source:HGNC Symbol;Acc:HGNC:13022] None DBD and Full not tested None None b Yes No No 4a, two or more datasets predict it as a TF Pratyush Das Arttu Jolma Yes $#ENSG00000278318#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000479807#ENSG00000278318#ENST00000613197#C2H2 ZF Containing Proteins#KRAB$#ENSP00000479884#ENSG00000278318#ENST00000614049#C2H2 ZF Containing Proteins#KRAB$#ENSP00000464902#ENSG00000278318#ENST00000592308#C2H2 ZF Containing Proteins# TRUE 532 ENSG00000167377 ZNF23 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001909;IPR007087;IPR015880; 7571 zinc finger protein 23 [Source:HGNC Symbol;Acc:HGNC:13023] None DBD and Full not tested None None a Yes No Yes 1a1, Direct HQ evidence Laura Campitelli Sam Lambert Yes $#ENSG00000167377#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000377171#ENSG00000167377#ENST00000393539#C2H2 ZF Containing Proteins#$#ENSP00000387673#ENSG00000167377#ENST00000428724#C2H2 ZF Containing Proteins#$#ENSP00000462429#ENSG00000167377#ENST00000564528#C2H2 ZF Containing Proteins#$#ENSP00000349796#ENSG00000167377#ENST00000357254#C2H2 ZF Containing Proteins# TRUE 533 ENSG00000159882 ZNF230 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Has nice array of znf domains and a KRAB domain IPR001909;IPR007087;IPR015880; 7773 zinc finger protein 230 [Source:HGNC Symbol;Acc:HGNC:13024] None DBD and Full not tested None None a Yes No No 4a, two or more datasets predict it as a TF Arttu Jolma Sam Lambert Yes None $#ENSP00000409318#ENSG00000159882#ENST00000429154#C2H2 ZF Containing Proteins#KRAB, zf-C2H2_4, zf-C2H2_6, zf-H2C2_2$#ENSP00000466541#ENSG00000159882#ENST00000585491#C2H2 ZF Containing Proteins#KRAB$#ENSP00000465988#ENSG00000159882#ENST00000585632#C2H2 ZF Containing Proteins#KRAB TRUE 534 ENSG00000167840 ZNF232 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR003309;IPR007087;IPR008916;IPR015880 7775 zinc finger protein 232 [Source:HGNC Symbol;Acc:HGNC:13026], alternative symbol is ZSCAN11 None DBD and Full not tested None None b Yes No No 1a1, Direct HQ evidence Pratyush Das Jussi Taipale Yes $#ENSG00000167840#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000461305#ENSG00000167840#ENST00000575898#C2H2 ZF Containing Proteins#SCAN$#ENSP00000250076#ENSG00000167840#ENST00000250076#C2H2 ZF Containing Proteins#SCAN FALSE 535 ENSG00000159915 ZNF233 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR001909;IPR007087;IPR015880; 353355 zinc finger protein 233 [Source:HGNC Symbol;Acc:HGNC:30946] None not tested not tested None None b Yes No No 4a, two or more datasets predict it as a TF Yimeng Yin Jussi Taipale Yes None $#ENSP00000375820#ENSG00000159915#ENST00000391958#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2$#ENSP00000465307#ENSG00000159915#ENST00000589522#C2H2 ZF Containing Proteins#KRAB$#ENSP00000468154#ENSG00000159915#ENST00000592581#C2H2 ZF Containing Proteins#KRAB$#ENSP00000466781#ENSG00000159915#ENST00000590668#C2H2 ZF Containing Proteins#KRAB TRUE 536 ENSG00000263002 ZNF234 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR001909;IPR007087;IPR015880; 10780 Zinc finger protein 234 [Source:HGNC Symbol;Acc:HGNC:13027] None DBD and Full not tested None None b Yes No Yes 4a, two or more datasets predict it as a TF Sam Lambert Jussi Taipale Yes $#ENSG00000263002#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000400878#ENSG00000263002#ENST00000426739#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2$#ENSP00000465011#ENSG00000263002#ENST00000592437#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2 TRUE 537 ENSG00000159917 ZNF235 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 9310 zinc finger protein 235 [Source:HGNC Symbol;Acc:HGNC:12866] None DBD not tested None None b Yes No Yes 1a1, Direct HQ evidence Pratyush Das Sam Lambert Yes $#ENSG00000159917#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000291182#ENSG00000159917#ENST00000291182#C2H2 ZF Containing Proteins#KRAB$#ENSP00000468695#ENSG00000159917#ENST00000589799#C2H2 ZF Containing Proteins#KRAB$#ENSP00000468609#ENSG00000159917#ENST00000589248#C2H2 ZF Containing Proteins#KRAB$#ENSP00000465880#ENSG00000159917#ENST00000591609#C2H2 ZF Containing Proteins#KRAB TRUE 538 ENSG00000130856 ZNF236 C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain None IPR007087;IPR015880 7776 zinc finger protein 236 [Source:HGNC Symbol;Acc:HGNC:13028] None Full not tested None None a Yes No No 2a1, Lower confidence direct evidence Yimeng Yin Pratyush Das Yes None $#ENSP00000253159#ENSG00000130856#ENST00000253159#C2H2 ZF Containing Proteins#$#ENSP00000322361#ENSG00000130856#ENST00000320610#C2H2 ZF Containing Proteins#$#ENSP00000463787#ENSG00000130856#ENST00000579322#C2H2 ZF Containing Proteins# FALSE 539 ENSG00000196793 ZNF239 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Binds TAAAGGCT based on EMSA (PMID: 11278819). IPR007087;IPR015880 8187 zinc finger protein 239 [Source:HGNC Symbol;Acc:HGNC:13031] None DBD and Full not tested None None b Yes TF Gene Candidate_DNA-Binding: sequence-specific_DNA Binding; Other_PMIDS:11278819 Yes 4a, two or more datasets predict it as a TF Pratyush Das Arttu Jolma Yes $#ENSG00000196793#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000307774#ENSG00000196793#ENST00000306006#C2H2 ZF Containing Proteins#$#ENSP00000363569#ENSG00000196793#ENST00000374446#C2H2 ZF Containing Proteins#$#ENSP00000398202#ENSG00000196793#ENST00000426961#C2H2 ZF Containing Proteins#$#ENSP00000443907#ENSG00000196793#ENST00000535642#C2H2 ZF Containing Proteins# FALSE 540 ENSG00000172466 ZNF24 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR003309;IPR007087;IPR008916;IPR015880 7572 zinc finger protein 24 [Source:HGNC Symbol;Acc:HGNC:13032] None DBD and Full not tested None None a Yes No Yes 4a, two or more datasets predict it as a TF Jussi Taipale Laura Campitelli Yes $#ENSG00000172466#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000261332#ENSG00000172466#ENST00000261332#C2H2 ZF Containing Proteins#SCAN$#ENSP00000382015#ENSG00000172466#ENST00000399061#C2H2 ZF Containing Proteins#SCAN$#ENSP00000467655#ENSG00000172466#ENST00000589881#C2H2 ZF Containing Proteins#SCAN$#ENSP00000467608#ENSG00000172466#ENST00000589539#C2H2 ZF Containing Proteins#SCAN$#ENSP00000467432#ENSG00000172466#ENST00000590140#C2H2 ZF Containing Proteins#SCAN FALSE 541 ENSG00000198105 ZNF248 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 57209 zinc finger protein 248 [Source:HGNC Symbol;Acc:HGNC:13041] None DBD and Full not tested None None b Yes No No 1a1, Direct HQ evidence Jussi Taipale Pratyush Das Yes None $#ENSP00000363778#ENSG00000198105#ENST00000374648#C2H2 ZF Containing Proteins#KRAB$#ENSP00000379208#ENSG00000198105#ENST00000395867#C2H2 ZF Containing Proteins#KRAB, zf-AN1, zf-C2H2_4, zf-C2H2_6$#ENSP00000484191#ENSG00000198105#ENST00000611278#C2H2 ZF Containing Proteins#KRAB$#ENSP00000349882#ENSG00000198105#ENST00000357328#C2H2 ZF Containing Proteins#KRAB, zf-AN1, zf-C2H2_4, zf-C2H2_6$#ENSP00000379214#ENSG00000198105#ENST00000395873#C2H2 ZF Containing Proteins#KRAB$#ENSP00000379215#ENSG00000198105#ENST00000395874#C2H2 ZF Containing Proteins#KRAB TRUE 542 ENSG00000175395 ZNF25 C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect None IPR001909;IPR007087;IPR015880; 219749 zinc finger protein 25 [Source:HGNC Symbol;Acc:HGNC:13043] None DBD and Full not tested None None a Yes No No 1a1, Direct HQ evidence Pratyush Das Arttu Jolma Yes None $#ENSP00000302222#ENSG00000175395#ENST00000302609#C2H2 ZF Containing Proteins#KRAB TRUE 543 ENSG00000196150 ZNF250 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001909;IPR007087;IPR015880; 58500 zinc finger protein 250 [Source:HGNC Symbol;Acc:HGNC:13044] None Full not tested None None b Yes No Yes 1a1, Direct HQ evidence Jussi Taipale Laura Campitelli Yes $#ENSG00000196150#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000292579#ENSG00000196150#ENST00000292579#C2H2 ZF Containing Proteins#KRAB$#ENSP00000393442#ENSG00000196150#ENST00000417550#C2H2 ZF Containing Proteins#KRAB$#ENSP00000433725#ENSG00000196150#ENST00000527049#C2H2 ZF Containing Proteins#KRAB$#ENSP00000432702#ENSG00000196150#ENST00000533221#C2H2 ZF Containing Proteins#KRAB$#ENSP00000433387#ENSG00000196150#ENST00000533622#C2H2 ZF Containing Proteins#KRAB TRUE 544 ENSG00000198169 ZNF251 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains and a KRAB-domain IPR001909;IPR007087;IPR015880; 90987 zinc finger protein 251 [Source:HGNC Symbol;Acc:HGNC:13045] None DBD not tested None None b Yes No No 4a, two or more datasets predict it as a TF Sam Lambert Arttu Jolma Yes $#ENSG00000198169#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000292562#ENSG00000198169#ENST00000292562#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2$#ENSP00000431809#ENSG00000198169#ENST00000525191#C2H2 ZF Containing Proteins#KRAB TRUE 545 ENSG00000256771 ZNF253 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains and a KRAB-domain IPR000754;IPR001909;IPR007087;IPR015880;IPR020568; 56242 zinc finger protein 90 [Source:HGNC Symbol;Acc:HGNC:13165] None Full not tested None None b Yes No No 1a1, Direct HQ evidence Laura Campitelli Arttu Jolma Yes None $#ENSP00000347868#ENSG00000256771#ENST00000355650#C2H2 ZF Containing Proteins#$#ENSP00000468720#ENSG00000256771#ENST00000589717#C2H2 ZF Containing Proteins#KRAB$#ENSP00000467235#ENSG00000256771#ENST00000592725#C2H2 ZF Containing Proteins# TRUE 546 ENSG00000213096 ZNF254 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 9534 zinc finger protein 254 [Source:HGNC Symbol;Acc:HGNC:13047] None DBD and Full not tested None None a Yes No Yes 1a1, Direct HQ evidence Jussi Taipale Sam Lambert Yes $#ENSG00000213096#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000341573#ENSG00000213096#ENST00000339642#C2H2 ZF Containing Proteins#KRAB$#ENSP00000349494#ENSG00000213096#ENST00000357002#C2H2 ZF Containing Proteins#KRAB$#ENSP00000483222#ENSG00000213096#ENST00000611359#C2H2 ZF Containing Proteins#$#ENSP00000482703#ENSG00000213096#ENST00000613065#C2H2 ZF Containing Proteins# TRUE 547 ENSG00000152454 ZNF256 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains and a KRAB-domain IPR001909;IPR007087;IPR015880; 10172 zinc finger protein 256 [Source:HGNC Symbol;Acc:HGNC:13049] None DBD and Full not tested None None b Yes No Yes 4a, two or more datasets predict it as a TF Sam Lambert Arttu Jolma Yes $#ENSG00000152454#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:10585455 $#ENSP00000282308#ENSG00000152454#ENST00000282308#C2H2 ZF Containing Proteins#KRAB$#ENSP00000472858#ENSG00000152454#ENST00000598928#C2H2 ZF Containing Proteins# TRUE 548 ENSG00000197134 ZNF257 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 113835 zinc finger protein 257 [Source:HGNC Symbol;Acc:HGNC:13498] None not tested not tested None None b Yes No No 1a1, Direct HQ evidence Sam Lambert Laura Campitelli Yes None $#ENSP00000471334#ENSG00000197134#ENST00000597927#C2H2 ZF Containing Proteins#$#ENSP00000469703#ENSG00000197134#ENST00000600162#C2H2 ZF Containing Proteins#KRAB$#ENSP00000470209#ENSG00000197134#ENST00000594947#C2H2 ZF Containing Proteins#KRAB$#ENSP00000469454#ENSG00000197134#ENST00000594363#C2H2 ZF Containing Proteins#KRAB TRUE 549 ENSG00000198393 ZNF26 C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect None IPR001909;IPR007087;IPR015880; 7574 zinc finger protein 26 [Source:HGNC Symbol;Acc:HGNC:13053] None DBD and Full not tested None None a Yes No Yes 1a1, Direct HQ evidence Sam Lambert Jussi Taipale Yes $#ENSG00000198393#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000333725#ENSG00000198393#ENST00000328654#C2H2 ZF Containing Proteins#KRAB$#ENSP00000437420#ENSG00000198393#ENST00000534834#C2H2 ZF Containing Proteins#KRAB$#ENSP00000443888#ENSG00000198393#ENST00000540238#C2H2 ZF Containing Proteins#KRAB$#ENSP00000445494#ENSG00000198393#ENST00000544181#C2H2 ZF Containing Proteins#KRAB TRUE 550 ENSG00000254004 ZNF260 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR007087;IPR015880 339324 zinc finger protein 260 [Source:HGNC Symbol;Acc:HGNC:13499] None DBD and Full not tested None None a Yes No Yes 4a, two or more datasets predict it as a TF Pratyush Das Laura Campitelli Yes $#ENSG00000254004#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000464964#ENSG00000254004#ENST00000592282#C2H2 ZF Containing Proteins#$#ENSP00000465834#ENSG00000254004#ENST00000593142#C2H2 ZF Containing Proteins#$#ENSP00000429803#ENSG00000254004#ENST00000523638#C2H2 ZF Containing Proteins#$#ENSP00000467219#ENSG00000254004#ENST00000588993#C2H2 ZF Containing Proteins# FALSE 551 ENSG00000006194 ZNF263 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001909;IPR003309;IPR007087;IPR008916;IPR015880; 10127 zinc finger protein 263 [Source:HGNC Symbol;Acc:HGNC:13056] None DBD and Full not tested None None b Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:12024037 Yes 1a1, Direct HQ evidence Sam Lambert Arttu Jolma Yes $#ENSG00000006194#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002 $#ENSP00000219069#ENSG00000006194#ENST00000219069#C2H2 ZF Containing Proteins#KRAB, SCAN$#ENSP00000444497#ENSG00000006194#ENST00000538765#C2H2 ZF Containing Proteins#$#ENSP00000461861#ENSG00000006194#ENST00000572748#C2H2 ZF Containing Proteins#SCAN$#ENSP00000459998#ENSG00000006194#ENST00000574253#C2H2 ZF Containing Proteins#SCAN$#ENSP00000461755#ENSG00000006194#ENST00000574674#C2H2 ZF Containing Proteins#$#ENSP00000458214#ENSG00000006194#ENST00000575823#C2H2 ZF Containing Proteins#SCAN$#ENSP00000461146#ENSG00000006194#ENST00000575332#C2H2 ZF Containing Proteins# TRUE 552 ENSG00000083844 ZNF264 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 9422 zinc finger protein 264 [Source:HGNC Symbol;Acc:HGNC:13057] None DBD and Full not tested None None b Yes No No 1a1, Direct HQ evidence Pratyush Das Yimeng Yin Yes None $#ENSP00000440376#ENSG00000083844#ENST00000536056#C2H2 ZF Containing Proteins#KRAB$#ENSP00000263095#ENSG00000083844#ENST00000263095#C2H2 ZF Containing Proteins#KRAB$#ENSP00000471630#ENSG00000083844#ENST00000599653#C2H2 ZF Containing Proteins#KRAB$#ENSP00000470759#ENSG00000083844#ENST00000600531#C2H2 ZF Containing Proteins#KRAB$#ENSP00000469130#ENSG00000083844#ENST00000594126#C2H2 ZF Containing Proteins#KRAB$#ENSP00000470587#ENSG00000083844#ENST00000597447#C2H2 ZF Containing Proteins#KRAB TRUE 553 ENSG00000174652 ZNF266 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR003656;IPR007087;IPR015880 10781 zinc finger protein 266 [Source:HGNC Symbol;Acc:HGNC:13059] None DBD and Full not tested None None b Yes No No 1a1, Direct HQ evidence Sam Lambert Yimeng Yin Yes None $#ENSP00000467151#ENSG00000174652#ENST00000588933#C2H2 ZF Containing Proteins#zf-H2C2_2$#ENSP00000467315#ENSG00000174652#ENST00000590306#C2H2 ZF Containing Proteins#zf-H2C2_2$#ENSP00000467923#ENSG00000174652#ENST00000591213#C2H2 ZF Containing Proteins#$#ENSP00000466714#ENSG00000174652#ENST00000592904#C2H2 ZF Containing Proteins#zf-H2C2_2$#ENSP00000468491#ENSG00000174652#ENST00000588221#C2H2 ZF Containing Proteins#zf-H2C2_2 TRUE 554 ENSG00000185947 ZNF267 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 10308 zinc finger protein 267 [Source:HGNC Symbol;Acc:HGNC:13060] None DBD and Full not tested None None a Yes No Yes 1a1, Direct HQ evidence Sam Lambert Arttu Jolma Yes $#ENSG00000185947#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000300870#ENSG00000185947#ENST00000300870#C2H2 ZF Containing Proteins#KRAB$#ENSP00000461286#ENSG00000185947#ENST00000394846#C2H2 ZF Containing Proteins#KRAB$#ENSP00000455493#ENSG00000185947#ENST00000562971#C2H2 ZF Containing Proteins#KRAB TRUE 555 ENSG00000090612 ZNF268 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Contains znfC2H2 domains and a KRAB-domain; linked to cervical cancer through effects on NFKB-signaling (PMID: 23091055). IPR001909;IPR007087;IPR015880; 10795 zinc finger protein 268 [Source:HGNC Symbol;Acc:HGNC:13061] None DBD and Full not tested None None b No No No 5a, one of the source datasets predicts is as a TF Arttu Jolma Pratyush Das Yes $#ENSG00000090612#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 | NAS - PMID:11311945 $##ENSG00000090612##C2H2 ZF Containing Proteins# TRUE 556 ENSG00000198039 ZNF273 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 10793 zinc finger protein 273 [Source:HGNC Symbol;Acc:HGNC:13067] None DBD and Full not tested None None a Yes No No 1a1, Direct HQ evidence Sam Lambert Arttu Jolma Yes None $#ENSP00000418719#ENSG00000198039#ENST00000476120#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2 TRUE 557 ENSG00000171606 ZNF274 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001909;IPR003309;IPR007087;IPR008916;IPR015880; 10782 zinc finger protein 274 [Source:HGNC Symbol;Acc:HGNC:13068] None DBD and Full not tested None None a Yes TF Gene Candidate_DNA-Binding: sequence-specific_Transactivation_PMIDS:10777669 Yes 1a1, Direct HQ evidence Sam Lambert Jussi Taipale Yes $#ENSG00000171606#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000171606#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:10777669 $#ENSP00000321209#ENSG00000171606#ENST00000326804#C2H2 ZF Containing Proteins#KRAB, SCAN$#ENSP00000321187#ENSG00000171606#ENST00000345813#C2H2 ZF Containing Proteins#KRAB, SCAN$#ENSP00000409872#ENSG00000171606#ENST00000424679#C2H2 ZF Containing Proteins#KRAB, SCAN$#ENSP00000484810#ENSG00000171606#ENST00000617501#C2H2 ZF Containing Proteins#KRAB, SCAN TRUE 558 ENSG00000063587 ZNF275 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR007087;IPR015880 105373378 zinc finger protein 275 [Source:HGNC Symbol;Acc:HGNC:13069] None not tested not tested None None b Yes No No 4a, two or more datasets predict it as a TF Laura Campitelli Pratyush Das Yes $#ENSG00000063587#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000359269#ENSG00000063587#ENST00000370249#C2H2 ZF Containing Proteins#HypA$#ENSP00000359271#ENSG00000063587#ENST00000370251#C2H2 ZF Containing Proteins# FALSE 559 ENSG00000158805 ZNF276 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR007087;IPR012934;IPR015880; 92822 zinc finger protein 276 [Source:HGNC Symbol;Acc:HGNC:23330] None DBD and Full not tested None None b Yes No No 1a1, Direct HQ evidence Sam Lambert Arttu Jolma Yes None $#ENSP00000289816#ENSG00000158805#ENST00000289816#C2H2 ZF Containing Proteins#zf-AD$#ENSP00000415836#ENSG00000158805#ENST00000443381#C2H2 ZF Containing Proteins#zf-AD$#ENSP00000457210#ENSG00000158805#ENST00000568064#C2H2 ZF Containing Proteins#zf-AD FALSE 560 ENSG00000198538 ZNF28 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 7576 zinc finger protein 28 [Source:HGNC Symbol;Acc:HGNC:13073] None DBD and Full not tested None None a Yes No Yes 1a1, Direct HQ evidence Pratyush Das Jussi Taipale Yes $#ENSG00000198538#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000397693#ENSG00000198538#ENST00000457749#C2H2 ZF Containing Proteins#KRAB$#ENSP00000375661#ENSG00000198538#ENST00000391783#C2H2 ZF Containing Proteins#$#ENSP00000412143#ENSG00000198538#ENST00000438150#C2H2 ZF Containing Proteins#$#ENSP00000344777#ENSG00000198538#ENST00000339844#C2H2 ZF Containing Proteins#KRAB TRUE 561 ENSG00000169548 ZNF280A C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect None IPR007087;IPR015880;IPR025243; 129025 zinc finger protein 280A [Source:HGNC Symbol;Acc:HGNC:18597] None Full not tested None None b No No No 1a1, Direct HQ evidence Sam Lambert Pratyush Das Yes $#ENSG00000169548#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IBA - GO_REF:0000033 $#ENSP00000302855#ENSG00000169548#ENST00000302097#C2H2 ZF Containing Proteins#DUF4195, zf-C2H2_4, zf-C2H2_6, zf-H2C2_2 FALSE 562 ENSG00000275004 ZNF280B C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None None 140883 Zinc finger protein 280B None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Pratyush Das Arttu Jolma Yes $#ENSG00000275004#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IBA - GO_REF:0000033 $##ENSG00000275004##C2H2 ZF Containing Proteins# FALSE 563 ENSG00000056277 ZNF280C C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR007087;IPR015880;IPR025243; 55609 zinc finger protein 280C [Source:HGNC Symbol;Acc:HGNC:25955] None Full Yes None None b No No Yes 4a, two or more datasets predict it as a TF Yimeng Yin Laura Campitelli Yes $#ENSG00000056277#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IBA - GO_REF:0000033 $#ENSP00000360017#ENSG00000056277#ENST00000370978#C2H2 ZF Containing Proteins#DUF4195, zf-C2H2_4, zf-Di19$#ENSP00000408521#ENSG00000056277#ENST00000447817#C2H2 ZF Containing Proteins#DUF4195 FALSE 564 ENSG00000137871 ZNF280D C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR007087;IPR015880;IPR025243; 145783 zinc finger protein 280D [Source:HGNC Symbol;Acc:HGNC:25953] None not tested not tested None None b No No Yes 4a, two or more datasets predict it as a TF Yimeng Yin Arttu Jolma Yes $#ENSG00000137871#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IBA - GO_REF:0000033 $#ENSP00000267807#ENSG00000137871#ENST00000267807#C2H2 ZF Containing Proteins#DUF4195, zf-Di19, zf-H2C2_2$#ENSP00000453706#ENSG00000137871#ENST00000558320#C2H2 ZF Containing Proteins#DUF4195$#ENSP00000454111#ENSG00000137871#ENST00000559237#C2H2 ZF Containing Proteins#DUF4195, zf-Di19, zf-H2C2_2$#ENSP00000453045#ENSG00000137871#ENST00000559000#C2H2 ZF Containing Proteins#DUF4195, zf-Di19, zf-H2C2_2 FALSE 565 ENSG00000162702 ZNF281 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR007087;IPR015880 23528 zinc finger protein 281 [Source:HGNC Symbol;Acc:HGNC:13075] None DBD and Full not tested None None a Yes No Yes 1a1, Direct HQ evidence Pratyush Das Arttu Jolma Yes $#ENSG00000162702#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:10448078$#ENSG00000162702#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:10448078 $#ENSP00000294740#ENSG00000162702#ENST00000294740#C2H2 ZF Containing Proteins#$#ENSP00000356322#ENSG00000162702#ENST00000367353#C2H2 ZF Containing Proteins#$#ENSP00000356321#ENSG00000162702#ENST00000367352#C2H2 ZF Containing Proteins# FALSE 566 ENSG00000170265 ZNF282 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001909;IPR007087;IPR015880;IPR022137 8427 zinc finger protein 282 [Source:HGNC Symbol;Acc:HGNC:13076] None DBD and Full not tested None None a Yes No No 1a1, Direct HQ evidence Pratyush Das Arttu Jolma Yes None $#ENSP00000477841#ENSG00000170265#ENST00000610704#C2H2 ZF Containing Proteins#DUF3669, KRAB$#ENSP00000418840#ENSG00000170265#ENST00000479907#C2H2 ZF Containing Proteins#DUF3669, KRAB TRUE 567 ENSG00000167637 ZNF283 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 284349 zinc finger protein 283 [Source:HGNC Symbol;Acc:HGNC:13077] None DBD not tested None None b No No No 1a1, Direct HQ evidence Pratyush Das Jussi Taipale Yes $#ENSG00000167637#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $##ENSG00000167637##C2H2 ZF Containing Proteins# TRUE 568 ENSG00000186026 ZNF284 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 342909 zinc finger protein 284 [Source:HGNC Symbol;Acc:HGNC:13078] None DBD not tested None None b Yes No Yes 1a1, Direct HQ evidence Yimeng Yin Arttu Jolma Yes $#ENSG00000186026#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000411032#ENSG00000186026#ENST00000421176#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2 TRUE 569 ENSG00000267508 ZNF285 C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect None IPR001909;IPR007087;IPR015880 26974 Zinc finger protein 285 [Source:HGNC Symbol;Acc:HGNC:13079] None Full not tested None None No Yes No No 1a1, Direct HQ evidence Pratyush Das Jussi Taipale Yes None $#ENSP00000483662#ENSG00000267508#ENST00000614994#C2H2 ZF Containing Proteins#KRAB, zf-C2H2_4, zf-H2C2_2$#ENSP00000468399#ENSG00000267508#ENST00000585868#C2H2 ZF Containing Proteins#$#ENSP00000464788#ENSG00000267508#ENST00000591679#C2H2 ZF Containing Proteins#KRAB, zf-C2H2_4, zf-H2C2_2$#ENSP00000439431#ENSG00000267508#ENST00000544719#C2H2 ZF Containing Proteins#KRAB, zf-C2H2_4, zf-H2C2_2 TRUE 570 ENSG00000187607 ZNF286A C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains and a KRAB-domain IPR001909;IPR007087;IPR015880; 57335 zinc finger protein 286A [Source:HGNC Symbol;Acc:HGNC:13501] None DBD and Full not tested None None b Yes No Yes 4a, two or more datasets predict it as a TF Arttu Jolma Sam Lambert Yes $#ENSG00000187607#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000379231#ENSG00000187607#ENST00000395894#C2H2 ZF Containing Proteins#KRAB$#ENSP00000464218#ENSG00000187607#ENST00000464847#C2H2 ZF Containing Proteins#KRAB$#ENSP00000467116#ENSG00000187607#ENST00000481540#C2H2 ZF Containing Proteins#KRAB$#ENSP00000464063#ENSG00000187607#ENST00000583566#C2H2 ZF Containing Proteins#KRAB$#ENSP00000461982#ENSG00000187607#ENST00000472486#C2H2 ZF Containing Proteins#KRAB$#ENSP00000379230#ENSG00000187607#ENST00000395893#C2H2 ZF Containing Proteins#KRAB$#ENSP00000466154#ENSG00000187607#ENST00000593105#C2H2 ZF Containing Proteins#KRAB TRUE 571 ENSG00000249459 ZNF286B C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains IPR007087;IPR015880 729288 zinc finger protein 286B [Source:HGNC Symbol;Acc:HGNC:33241] None not tested not tested None None No Yes No Yes 4a, two or more datasets predict it as a TF Yimeng Yin Arttu Jolma Yes $#ENSG00000249459#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000463300#ENSG00000249459#ENST00000583002#C2H2 ZF Containing Proteins#$#ENSP00000460210#ENSG00000249459#ENST00000285274#C2H2 ZF Containing Proteins#RNA_pol_A_CTD$#ENSP00000460736#ENSG00000249459#ENST00000443457#C2H2 ZF Containing Proteins# FALSE 572 ENSG00000141040 ZNF287 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR003309;IPR007087;IPR008916;IPR015880; 57336 Zinc finger protein 287 [Source:HGNC Symbol;Acc:HGNC:13502] None DBD and Full not tested None None b Yes No No 1a1, Direct HQ evidence Jussi Taipale Yimeng Yin Yes $#ENSG00000141040#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002 $#ENSP00000379168#ENSG00000141040#ENST00000395824#C2H2 ZF Containing Proteins#KRAB, SCAN$#ENSP00000379169#ENSG00000141040#ENST00000395825#C2H2 ZF Containing Proteins#KRAB, SCAN$#ENSP00000406051#ENSG00000141040#ENST00000448349#C2H2 ZF Containing Proteins# TRUE 573 ENSG00000188994 ZNF292 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR007087;IPR015880 23036 zinc finger protein 292 [Source:HGNC Symbol;Acc:HGNC:18410] None not tested not tested None None b Yes Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0 Yes 4a, two or more datasets predict it as a TF Pratyush Das Arttu Jolma Yes $#ENSG00000188994#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019 $#ENSP00000430569#ENSG00000188994#ENST00000392985#C2H2 ZF Containing Proteins#$#ENSP00000358590#ENSG00000188994#ENST00000369577#C2H2 ZF Containing Proteins#zf-C2H2_4, zf-C2H2_6, zf-H2C2_5$#ENSP00000428857#ENSG00000188994#ENST00000496806#C2H2 ZF Containing Proteins#$#ENSP00000428925#ENSG00000188994#ENST00000518845#C2H2 ZF Containing Proteins# FALSE 574 ENSG00000170684 ZNF296 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR007087;IPR015880 162979 zinc finger protein 296 [Source:HGNC Symbol;Acc:HGNC:15981] None DBD and Full not tested None None b Yes No No 1a1, Direct HQ evidence Sam Lambert Arttu Jolma Yes None $#ENSP00000302770#ENSG00000170684#ENST00000303809#C2H2 ZF Containing Proteins#$#ENSP00000479435#ENSG00000170684#ENST00000622376#C2H2 ZF Containing Proteins# FALSE 575 ENSG00000166526 ZNF3 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 7551 zinc finger protein 3 [Source:HGNC Symbol;Acc:HGNC:13089] None DBD and Full not tested None None a Yes No Yes 1a1, Direct HQ evidence Sam Lambert Laura Campitelli Yes $#ENSG00000166526#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000299667#ENSG00000166526#ENST00000299667#C2H2 ZF Containing Proteins#KRAB$#ENSP00000416088#ENSG00000166526#ENST00000412947#C2H2 ZF Containing Proteins#KRAB$#ENSP00000399951#ENSG00000166526#ENST00000413658#C2H2 ZF Containing Proteins#KRAB$#ENSP00000416686#ENSG00000166526#ENST00000415068#C2H2 ZF Containing Proteins#KRAB$#ENSP00000292393#ENSG00000166526#ENST00000292393#C2H2 ZF Containing Proteins#$#ENSP00000388042#ENSG00000166526#ENST00000428683#C2H2 ZF Containing Proteins#KRAB$#ENSP00000415358#ENSG00000166526#ENST00000424697#C2H2 ZF Containing Proteins#KRAB$#ENSP00000405970#ENSG00000166526#ENST00000449785#C2H2 ZF Containing Proteins#KRAB TRUE 576 ENSG00000168661 ZNF30 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 90075 zinc finger protein 30 [Source:HGNC Symbol;Acc:HGNC:13090] None DBD and Full not tested None None a Yes No Yes 1a1, Direct HQ evidence Pratyush Das Sam Lambert Yes $#ENSG00000168661#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000303889#ENSG00000168661#ENST00000303586#C2H2 ZF Containing Proteins#KRAB$#ENSP00000469954#ENSG00000168661#ENST00000601142#C2H2 ZF Containing Proteins#KRAB$#ENSP00000470094#ENSG00000168661#ENST00000601957#C2H2 ZF Containing Proteins#KRAB$#ENSP00000476813#ENSG00000168661#ENST00000601540#C2H2 ZF Containing Proteins#KRAB TRUE 577 ENSG00000145908 ZNF300 C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect None IPR001909;IPR007087;IPR015880; 91975 zinc finger protein 300 [Source:HGNC Symbol;Acc:HGNC:13091] None DBD and Full not tested None None b Yes No Yes 1a1, Direct HQ evidence Yimeng Yin Arttu Jolma Yes $#ENSG00000145908#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000274599#ENSG00000145908#ENST00000274599#C2H2 ZF Containing Proteins#KRAB$#ENSP00000397178#ENSG00000145908#ENST00000446148#C2H2 ZF Containing Proteins#KRAB$#ENSP00000392593#ENSG00000145908#ENST00000418587#C2H2 ZF Containing Proteins#$#ENSP00000414195#ENSG00000145908#ENST00000427179#C2H2 ZF Containing Proteins#KRAB TRUE 578 ENSG00000089335 ZNF302 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 55900 zinc finger protein 302 [Source:HGNC Symbol;Acc:HGNC:13848] None DBD and Full not tested None None b Yes No No 1a1, Direct HQ evidence Jussi Taipale Laura Campitelli Yes $#ENSG00000089335#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000405219#ENSG00000089335#ENST00000423823#C2H2 ZF Containing Proteins#KRAB$#ENSP00000391067#ENSG00000089335#ENST00000457781#C2H2 ZF Containing Proteins#KRAB$#ENSP00000421028#ENSG00000089335#ENST00000505242#C2H2 ZF Containing Proteins#KRAB$#ENSP00000396379#ENSG00000089335#ENST00000446502#C2H2 ZF Containing Proteins#KRAB$#ENSP00000423235#ENSG00000089335#ENST00000505365#C2H2 ZF Containing Proteins#KRAB$#ENSP00000421201#ENSG00000089335#ENST00000507959#C2H2 ZF Containing Proteins#KRAB$#ENSP00000424292#ENSG00000089335#ENST00000506901#C2H2 ZF Containing Proteins#KRAB TRUE 579 ENSG00000131845 ZNF304 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 57343 zinc finger protein 304 [Source:HGNC Symbol;Acc:HGNC:13505] None Full not tested None None b Yes No Yes 1a1, Direct HQ evidence Sam Lambert Laura Campitelli Yes $#ENSG00000131845#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000401642#ENSG00000131845#ENST00000443917#C2H2 ZF Containing Proteins#KRAB$#ENSP00000470319#ENSG00000131845#ENST00000598744#C2H2 ZF Containing Proteins#$#ENSP00000282286#ENSG00000131845#ENST00000282286#C2H2 ZF Containing Proteins#KRAB$#ENSP00000375586#ENSG00000131845#ENST00000391705#C2H2 ZF Containing Proteins#KRAB TRUE 580 ENSG00000197935 ZNF311 C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect None IPR001909;IPR007087;IPR015880; 282890 zinc finger protein 311 [Source:HGNC Symbol;Acc:HGNC:13847] None DBD and Full not tested None None b Yes No No 1a1, Direct HQ evidence Jussi Taipale Laura Campitelli Yes $#ENSG00000197935#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000366384#ENSG00000197935#ENST00000377179#C2H2 ZF Containing Proteins#KRAB TRUE 581 ENSG00000205903 ZNF316 C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain None IPR001909;IPR007087;IPR015880; 100131017 zinc finger protein 316 [Source:HGNC Symbol;Acc:HGNC:13843] None not tested not tested None None c Yes No No 2a1, Lower confidence direct evidence Laura Campitelli Arttu Jolma Yes None $#ENSP00000482395#ENSG00000205903#ENST00000427912#C2H2 ZF Containing Proteins#$#ENSP00000477706#ENSG00000205903#ENST00000382252#C2H2 ZF Containing Proteins#KRAB TRUE 582 ENSG00000130803 ZNF317 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 57693 zinc finger protein 317 [Source:HGNC Symbol;Acc:HGNC:13507] None Full not tested None The ChIP-seq model is similar to SOX-motif b Yes No Yes 1a1, Direct HQ evidence Arttu Jolma Yimeng Yin Yes $#ENSG00000130803#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000247956#ENSG00000130803#ENST00000247956#C2H2 ZF Containing Proteins#KRAB$#ENSP00000353554#ENSG00000130803#ENST00000360385#C2H2 ZF Containing Proteins#KRAB$#ENSP00000468213#ENSG00000130803#ENST00000591508#C2H2 ZF Containing Proteins# TRUE 583 ENSG00000171467 ZNF318 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Possible RNA-binding protein; it has two u1 type ZNF domains (PMID: 25057009). IPR003604; 24149 zinc finger protein 318 [Source:HGNC Symbol;Acc:HGNC:13578] None DBD not tested None None b No No No 5a, one of the source datasets predicts is as a TF Yimeng Yin Arttu Jolma No None $#ENSP00000354964#ENSG00000171467#ENST00000361428#C2H2 ZF Containing Proteins#FAM177, zf-U1$#ENSP00000475511#ENSG00000171467#ENST00000606599#C2H2 ZF Containing Proteins#zf-C2H2_2 FALSE 584 ENSG00000166188 ZNF319 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains IPR007087;IPR015880 57567 zinc finger protein 319 [Source:HGNC Symbol;Acc:HGNC:13644] None not tested not tested None None b Yes No No 4a, two or more datasets predict it as a TF Laura Campitelli Arttu Jolma Yes None $#ENSP00000299237#ENSG00000166188#ENST00000299237#C2H2 ZF Containing Proteins#$#ENSP00000457048#ENSG00000166188#ENST00000562909#C2H2 ZF Containing Proteins# FALSE 585 ENSG00000169740 ZNF32 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR007087;IPR015880 7580 zinc finger protein 32 [Source:HGNC Symbol;Acc:HGNC:13095] None DBD and Full Yes None None a Yes No No 1a1, Direct HQ evidence Pratyush Das Jussi Taipale Yes None $#ENSP00000363556#ENSG00000169740#ENST00000374433#C2H2 ZF Containing Proteins#zf-C2H2_4, zf-C2H2_6, zf-LYAR$#ENSP00000379143#ENSG00000169740#ENST00000395797#C2H2 ZF Containing Proteins#zf-C2H2_4, zf-C2H2_6, zf-LYAR FALSE 586 ENSG00000182986 ZNF320 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 162967 zinc finger protein 320 [Source:HGNC Symbol;Acc:HGNC:13842] None DBD and Full not tested None None b Yes No Yes 1a1, Direct HQ evidence Sam Lambert Jussi Taipale Yes $#ENSG00000182986#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000375660#ENSG00000182986#ENST00000391781#C2H2 ZF Containing Proteins#KRAB$#ENSP00000473091#ENSG00000182986#ENST00000595635#C2H2 ZF Containing Proteins#KRAB$#ENSP00000470403#ENSG00000182986#ENST00000594741#C2H2 ZF Containing Proteins#KRAB$#ENSP00000468995#ENSG00000182986#ENST00000597091#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2$#ENSP00000471938#ENSG00000182986#ENST00000597265#C2H2 ZF Containing Proteins#KRAB TRUE 587 ENSG00000181315 ZNF322 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR007087;IPR015880 79692 zinc finger protein 322 [Source:HGNC Symbol;Acc:HGNC:23640] None DBD and Full not tested None None a Yes No Yes 1a1, Direct HQ evidence Sam Lambert Arttu Jolma Yes $#ENSG00000181315#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000418897#ENSG00000181315#ENST00000415922#C2H2 ZF Containing Proteins#C1_4$#ENSP00000478899#ENSG00000181315#ENST00000456172#C2H2 ZF Containing Proteins#C1_4 FALSE 588 ENSG00000083812 ZNF324 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 25799 zinc finger protein 324 [Source:HGNC Symbol;Acc:HGNC:14096] None Full not tested None None b Yes No No 1a1, Direct HQ evidence Tim Hughes Pratyush Das Yes None $#ENSP00000196482#ENSG00000083812#ENST00000196482#C2H2 ZF Containing Proteins#KRAB$#ENSP00000444812#ENSG00000083812#ENST00000536459#C2H2 ZF Containing Proteins#KRAB$#ENSP00000471778#ENSG00000083812#ENST00000593925#C2H2 ZF Containing Proteins#$#ENSP00000439588#ENSG00000083812#ENST00000535298#C2H2 ZF Containing Proteins#KRAB TRUE 589 ENSG00000249471 ZNF324B C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect None IPR001909;IPR007087;IPR015880; 388569 zinc finger protein 324B [Source:HGNC Symbol;Acc:HGNC:33107] None not tested not tested None TFs that are in CisBP but not in Vaquerizas set No Yes No No 1a1, Direct HQ evidence Yimeng Yin Arttu Jolma Yes None $#ENSP00000337473#ENSG00000249471#ENST00000336614#C2H2 ZF Containing Proteins#KRAB$#ENSP00000438930#ENSG00000249471#ENST00000545523#C2H2 ZF Containing Proteins#KRAB$#ENSP00000471086#ENSG00000249471#ENST00000594214#C2H2 ZF Containing Proteins#KRAB$#ENSP00000473115#ENSG00000249471#ENST00000599193#C2H2 ZF Containing Proteins#KRAB TRUE 590 ENSG00000162664 ZNF326 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None ZNF326 is a member of the DBIRD complex that regulates splicing by binding to PolII in an RNA-independant manner (PMID:22446626). IPR007071; 284695 zinc finger protein 326 [Source:HGNC Symbol;Acc:HGNC:14104] None DBD and Full not tested None None b No Indeterminate - There is no evidence for or against this genes role as a TF__DNA Binding_PMIDS:9809746;10798446 No 4a, two or more datasets predict it as a TF Sam Lambert Yimeng Yin No None $#ENSP00000340796#ENSG00000162664#ENST00000340281#C2H2 ZF Containing Proteins#AKAP95$#ENSP00000355318#ENSG00000162664#ENST00000361911#C2H2 ZF Containing Proteins#$#ENSP00000359476#ENSG00000162664#ENST00000370447#C2H2 ZF Containing Proteins#AKAP95 FALSE 591 ENSG00000181894 ZNF329 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR007087;IPR015880 79673 zinc finger protein 329 [Source:HGNC Symbol;Acc:HGNC:14209] None Full not tested None None b Yes No No 1a1, Direct HQ evidence Arttu Jolma Sam Lambert Yes None $#ENSP00000350773#ENSG00000181894#ENST00000358067#C2H2 ZF Containing Proteins#$#ENSP00000470008#ENSG00000181894#ENST00000598312#C2H2 ZF Containing Proteins#$#ENSP00000471614#ENSG00000181894#ENST00000601887#C2H2 ZF Containing Proteins#$#ENSP00000470323#ENSG00000181894#ENST00000597186#C2H2 ZF Containing Proteins# FALSE 592 ENSG00000130844 ZNF331 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 55422 zinc finger protein 331 [Source:HGNC Symbol;Acc:HGNC:15489] None DBD and Full not tested None None b Yes No No 1a1, Direct HQ evidence Tim Hughes Jussi Taipale Yes None $#ENSP00000253144#ENSG00000130844#ENST00000253144#C2H2 ZF Containing Proteins#KRAB$#ENSP00000393336#ENSG00000130844#ENST00000411977#C2H2 ZF Containing Proteins#KRAB$#ENSP00000423675#ENSG00000130844#ENST00000502248#C2H2 ZF Containing Proteins#KRAB$#ENSP00000422586#ENSG00000130844#ENST00000502616#C2H2 ZF Containing Proteins#KRAB$#ENSP00000425517#ENSG00000130844#ENST00000504493#C2H2 ZF Containing Proteins#KRAB$#ENSP00000424929#ENSG00000130844#ENST00000505426#C2H2 ZF Containing Proteins#KRAB$#ENSP00000421014#ENSG00000130844#ENST00000511154#C2H2 ZF Containing Proteins#KRAB$#ENSP00000421728#ENSG00000130844#ENST00000512387#C2H2 ZF Containing Proteins#KRAB$#ENSP00000423156#ENSG00000130844#ENST00000513999#C2H2 ZF Containing Proteins#KRAB$#ENSP00000422471#ENSG00000130844#ENST00000514022#C2H2 ZF Containing Proteins#KRAB$#ENSP00000423263#ENSG00000130844#ENST00000509047#C2H2 ZF Containing Proteins#KRAB$#ENSP00000426458#ENSG00000130844#ENST00000513265#C2H2 ZF Containing Proteins#KRAB TRUE 593 ENSG00000160961 ZNF333 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR003656;IPR007087;IPR015880 84449 zinc finger protein 333 [Source:HGNC Symbol;Acc:HGNC:15624] None Full not tested None None b Yes No No 1a1, Direct HQ evidence Jussi Taipale Yimeng Yin Yes None $#ENSP00000292530#ENSG00000160961#ENST00000292530#C2H2 ZF Containing Proteins#KRAB$#ENSP00000438130#ENSG00000160961#ENST00000540689#C2H2 ZF Containing Proteins#KRAB$#ENSP00000472026#ENSG00000160961#ENST00000601134#C2H2 ZF Containing Proteins#KRAB TRUE 594 ENSG00000198185 ZNF334 C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect None IPR001909;IPR007087;IPR015880; 55713 zinc finger protein 334 [Source:HGNC Symbol;Acc:HGNC:15806] None DBD and Full not tested None None b Yes No Yes 1a1, Direct HQ evidence Laura Campitelli Arttu Jolma Yes $#ENSG00000198185#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000255129#ENSG00000198185#ENST00000347606#C2H2 ZF Containing Proteins#KRAB$#ENSP00000473194#ENSG00000198185#ENST00000593880#C2H2 ZF Containing Proteins#$#ENSP00000402582#ENSG00000198185#ENST00000457685#C2H2 ZF Containing Proteins#$#ENSP00000473164#ENSG00000198185#ENST00000596323#C2H2 ZF Containing Proteins#KRAB$#ENSP00000485779#ENSG00000198185#ENST00000625284#C2H2 ZF Containing Proteins#KRAB TRUE 595 ENSG00000198026 ZNF335 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif Has a putative AT-hook None IPR007087;IPR015880 63925 zinc finger protein 335 [Source:HGNC Symbol;Acc:HGNC:15807] None Full not tested None None b Yes No No 4a, two or more datasets predict it as a TF Laura Campitelli Yimeng Yin Yes None $#ENSP00000325326#ENSG00000198026#ENST00000322927#C2H2 ZF Containing Proteins#zf-C2H2_4 FALSE 596 ENSG00000130684 ZNF337 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 26152 zinc finger protein 337 [Source:HGNC Symbol;Acc:HGNC:15809] None Full not tested None None b Yes No No 1a1, Direct HQ evidence Pratyush Das Tim Hughes Yes None $#ENSP00000252979#ENSG00000130684#ENST00000252979#C2H2 ZF Containing Proteins#KRAB$#ENSP00000365619#ENSG00000130684#ENST00000376436#C2H2 ZF Containing Proteins#KRAB TRUE 597 ENSG00000189180 ZNF33A C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 7581 zinc finger protein 33A [Source:HGNC Symbol;Acc:HGNC:13096] None DBD and Full not tested None None b Yes No Yes 1a1, Direct HQ evidence Arttu Jolma Pratyush Das Yes $#ENSG00000189180#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 | NAS - PMID:8464732 $#ENSP00000402467#ENSG00000189180#ENST00000432900#C2H2 ZF Containing Proteins#KRAB$#ENSP00000387713#ENSG00000189180#ENST00000458705#C2H2 ZF Containing Proteins#KRAB$#ENSP00000485869#ENSG00000189180#ENST00000628825#C2H2 ZF Containing Proteins#KRAB TRUE 598 ENSG00000196693 ZNF33B C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 7582 zinc finger protein 33B [Source:HGNC Symbol;Acc:HGNC:13097] None Full not tested None None b Yes No Yes 1a1, Direct HQ evidence Laura Campitelli Yimeng Yin Yes $#ENSG00000196693#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000352444#ENSG00000196693#ENST00000359467#C2H2 ZF Containing Proteins#KRAB$#ENSP00000484085#ENSG00000196693#ENST00000462075#C2H2 ZF Containing Proteins#$#ENSP00000480979#ENSG00000196693#ENST00000465206#C2H2 ZF Containing Proteins#KRAB TRUE 599 ENSG00000196378 ZNF34 C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect None IPR001909;IPR007087;IPR015880; 80778 zinc finger protein 34 [Source:HGNC Symbol;Acc:HGNC:13098] None Full not tested None None b Yes No No 1a1, Direct HQ evidence Sam Lambert Yimeng Yin Yes None $#ENSP00000341528#ENSG00000196378#ENST00000343459#C2H2 ZF Containing Proteins#KRAB$#ENSP00000396894#ENSG00000196378#ENST00000429371#C2H2 ZF Containing Proteins#KRAB$#ENSP00000434049#ENSG00000196378#ENST00000534337#C2H2 ZF Containing Proteins#KRAB$#ENSP00000437056#ENSG00000196378#ENST00000534445#C2H2 ZF Containing Proteins#KRAB TRUE 600 ENSG00000131061 ZNF341 C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect None IPR007087;IPR015880 84905 zinc finger protein 341 [Source:HGNC Symbol;Acc:HGNC:15992] None Full not tested None None b Yes No Yes 1a1, Direct HQ evidence Jussi Taipale Sam Lambert Yes $#ENSG00000131061#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000344308#ENSG00000131061#ENST00000342427#C2H2 ZF Containing Proteins#$#ENSP00000364346#ENSG00000131061#ENST00000375200#C2H2 ZF Containing Proteins# FALSE 601 ENSG00000088876 ZNF343 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001909;IPR007087;IPR015880; 79175 zinc finger protein 343 [Source:HGNC Symbol;Acc:HGNC:16017] None DBD and Full not tested None None b Yes No No 1a1, Direct HQ evidence Jussi Taipale Laura Campitelli Yes None $#ENSP00000370652#ENSG00000088876#ENST00000381253#C2H2 ZF Containing Proteins#KRAB$#ENSP00000399682#ENSG00000088876#ENST00000445484#C2H2 ZF Containing Proteins#KRAB$#ENSP00000278772#ENSG00000088876#ENST00000278772#C2H2 ZF Containing Proteins#KRAB, zf-C2H2_4$#ENSP00000416488#ENSG00000088876#ENST00000421216#C2H2 ZF Containing Proteins#KRAB TRUE 602 ENSG00000251247 ZNF345 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001909;IPR007087;IPR015880; 25850 Zinc finger protein 345 [Source:HGNC Symbol;Acc:HGNC:16367] None DBD and Full not tested None None b Yes No Yes 1a1, Direct HQ evidence Pratyush Das Laura Campitelli Yes $#ENSG00000251247#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000431216#ENSG00000251247#ENST00000420450#C2H2 ZF Containing Proteins#$#ENSP00000431202#ENSG00000251247#ENST00000529555#C2H2 ZF Containing Proteins#$#ENSP00000465431#ENSG00000251247#ENST00000589046#C2H2 ZF Containing Proteins#$#ENSP00000467611#ENSG00000251247#ENST00000526123#C2H2 ZF Containing Proteins#$#ENSP00000431289#ENSG00000251247#ENST00000532141#C2H2 ZF Containing Proteins#zf-H2C2_2$#ENSP00000465851#ENSG00000251247#ENST00000585396#C2H2 ZF Containing Proteins#$#ENSP00000477522#ENSG00000251247#ENST00000614069#C2H2 ZF Containing Proteins# FALSE 603 ENSG00000113761 ZNF346 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Binds dsDNA with low affinity and no discernible specificity (PMID: 24521053). IPR003604;IPR007087;IPR015880; 23567 zinc finger protein 346 [Source:HGNC Symbol;Acc:HGNC:16403] None not tested not tested None None c No No No 5a, one of the source datasets predicts is as a TF Laura Campitelli Yimeng Yin No None $#ENSP00000350869#ENSG00000113761#ENST00000358149#C2H2 ZF Containing Proteins#zf-C2H2_2, zf-C2H2_jaz, zf-U1, zf-met$#ENSP00000424495#ENSG00000113761#ENST00000503039#C2H2 ZF Containing Proteins#zf-C2H2_2, zf-C2H2_jaz, zf-U1, zf-met$#ENSP00000421212#ENSG00000113761#ENST00000503425#C2H2 ZF Containing Proteins#zf-C2H2_2, zf-C2H2_4, zf-C2H2_jaz, zf-U1, zf-met$#ENSP00000423515#ENSG00000113761#ENST00000506693#C2H2 ZF Containing Proteins#zf-C2H2_2, zf-C2H2_jaz, zf-U1, zf-met$#ENSP00000421089#ENSG00000113761#ENST00000512315#C2H2 ZF Containing Proteins#zf-C2H2_jaz, zf-met FALSE 604 ENSG00000197937 ZNF347 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR001909;IPR007087;IPR015880; 84671 zinc finger protein 347 [Source:HGNC Symbol;Acc:HGNC:16447] None DBD not tested None None b Yes No No 4a, two or more datasets predict it as a TF Jussi Taipale Yimeng Yin Yes None $#ENSP00000334146#ENSG00000197937#ENST00000334197#C2H2 ZF Containing Proteins#KRAB$#ENSP00000405218#ENSG00000197937#ENST00000452676#C2H2 ZF Containing Proteins#KRAB$#ENSP00000469338#ENSG00000197937#ENST00000597183#C2H2 ZF Containing Proteins#$#ENSP00000471712#ENSG00000197937#ENST00000601469#C2H2 ZF Containing Proteins#KRAB$#ENSP00000470499#ENSG00000197937#ENST00000595967#C2H2 ZF Containing Proteins#KRAB$#ENSP00000471825#ENSG00000197937#ENST00000599096#C2H2 ZF Containing Proteins#KRAB TRUE 605 ENSG00000169981 ZNF35 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR007087;IPR015880 7584 zinc finger protein 35 [Source:HGNC Symbol;Acc:HGNC:13099] None DBD and Full not tested None None a Yes No Yes 1a1, Direct HQ evidence Yimeng Yin Jussi Taipale Yes $#ENSG00000169981#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:1572646 $#ENSP00000296092#ENSG00000169981#ENST00000296092#C2H2 ZF Containing Proteins#$#ENSP00000379368#ENSG00000169981#ENST00000396056#C2H2 ZF Containing Proteins#$#ENSP00000404354#ENSG00000169981#ENST00000415571#C2H2 ZF Containing Proteins#$#ENSP00000401311#ENSG00000169981#ENST00000453164#C2H2 ZF Containing Proteins# FALSE 606 ENSG00000256683 ZNF350 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 59348 zinc finger protein 350 [Source:HGNC Symbol;Acc:HGNC:16656] None DBD and Full not tested None None a Yes No Yes 2a1, Lower confidence direct evidence Sam Lambert Laura Campitelli Yes $#ENSG00000256683#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IDA - PMID:11090615 $#ENSP00000243644#ENSG00000256683#ENST00000243644#C2H2 ZF Containing Proteins#KRAB$#ENSP00000472104#ENSG00000256683#ENST00000593596#C2H2 ZF Containing Proteins#KRAB$#ENSP00000469594#ENSG00000256683#ENST00000594929#C2H2 ZF Containing Proteins#KRAB$#ENSP00000470930#ENSG00000256683#ENST00000601430#C2H2 ZF Containing Proteins# TRUE 607 ENSG00000169131 ZNF354A C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 6940 zinc finger protein 354A [Source:HGNC Symbol;Acc:HGNC:11628] None DBD and Full not tested None None b Yes TF Gene_DNA-Binding: non-sequence-specific_Transactivation_PMIDS:8183940;9346939 Yes 1a1, Direct HQ evidence Pratyush Das Arttu Jolma Yes $#ENSG00000169131#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000337122#ENSG00000169131#ENST00000335815#C2H2 ZF Containing Proteins#KRAB$#ENSP00000429675#ENSG00000169131#ENST00000520331#C2H2 ZF Containing Proteins#KRAB TRUE 608 ENSG00000178338 ZNF354B C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 117608 zinc finger protein 354B [Source:HGNC Symbol;Acc:HGNC:17197] None DBD and Full not tested None None b Yes No Yes 1a1, Direct HQ evidence Jussi Taipale Pratyush Das Yes $#ENSG00000178338#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000327143#ENSG00000178338#ENST00000322434#C2H2 ZF Containing Proteins#KRAB$#ENSP00000429827#ENSG00000178338#ENST00000520377#C2H2 ZF Containing Proteins#KRAB TRUE 609 ENSG00000177932 ZNF354C C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source None None IPR001909;IPR007087;IPR015880; 30832 zinc finger protein 354C [Source:HGNC Symbol;Acc:HGNC:16736] None Full not tested None None b Yes No Yes 1a1, Direct HQ evidence Sam Lambert Laura Campitelli Yes $#ENSG00000177932#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000324064#ENSG00000177932#ENST00000315475#C2H2 ZF Containing Proteins#KRAB TRUE 610 ENSG00000168122 ZNF355P C2H2 ZF No Unlikely to be sequence specific TF Not a DNA binding protein No motif Pseudogene None None None Putative zinc finger protein 355P None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Jussi Taipale Pratyush Das Yes $#ENSG00000168122#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $##ENSG00000168122##Other# FALSE 611 ENSG00000198816 ZNF358 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR007087;IPR015880 140467 zinc finger protein 358 [Source:HGNC Symbol;Acc:HGNC:16838] None DBD not tested None None b Yes No No 4a, two or more datasets predict it as a TF Sam Lambert Jussi Taipale Yes None $#ENSP00000472305#ENSG00000198816#ENST00000597229#C2H2 ZF Containing Proteins#$#ENSP00000472777#ENSG00000198816#ENST00000596712#C2H2 ZF Containing Proteins# FALSE 612 ENSG00000160094 ZNF362 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains IPR007087;IPR015880 149076 zinc finger protein 362 [Source:HGNC Symbol;Acc:HGNC:18079] None not tested not tested None None c Yes No No 4a, two or more datasets predict it as a TF Arttu Jolma Yimeng Yin Yes None $#ENSP00000362527#ENSG00000160094#ENST00000373428#C2H2 ZF Containing Proteins#$#ENSP00000438354#ENSG00000160094#ENST00000483388#C2H2 ZF Containing Proteins#$#ENSP00000446335#ENSG00000160094#ENST00000539719#C2H2 ZF Containing Proteins# FALSE 613 ENSG00000138311 ZNF365 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif Single C2H2 domain Also contains a Ku C terminal like domain that is thought to be involved in DNA-damage repair pathways. None 22891 zinc finger protein 365 [Source:HGNC Symbol;Acc:HGNC:18194] None DBD not tested None None b Yes No No 4a, two or more datasets predict it as a TF Sam Lambert Arttu Jolma No None $#ENSP00000378670#ENSG00000138311#ENST00000395249#C2H2 ZF Containing Proteins#$#ENSP00000378672#ENSG00000138311#ENST00000395251#C2H2 ZF Containing Proteins#$#ENSP00000378674#ENSG00000138311#ENST00000395254#C2H2 ZF Containing Proteins#$#ENSP00000378675#ENSG00000138311#ENST00000395255#C2H2 ZF Containing Proteins#Ku_PK_bind$#ENSP00000387091#ENSG00000138311#ENST00000410046#C2H2 ZF Containing Proteins# FALSE 614 ENSG00000178175 ZNF366 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None This protein has been shown to complex with and function as a corepressor for ESR1 (PMID: 17085477) and glucocorticoid receptor (PMID: 23440419). It has a nice set of znfs and could thus well bind DNA independently. IPR007087;IPR015880 167465 zinc finger protein 366 [Source:HGNC Symbol;Acc:HGNC:18316] None Full not tested None None b Yes No No 4a, two or more datasets predict it as a TF Arttu Jolma Pratyush Das Yes None $#ENSP00000313158#ENSG00000178175#ENST00000318442#C2H2 ZF Containing Proteins#$#ENSP00000391333#ENSG00000178175#ENST00000414109#C2H2 ZF Containing Proteins# FALSE 615 ENSG00000165244 ZNF367 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif Has a putative AT-hook Virtually nothing is known for this protein except that it has two znfC2H2 domains next to each other IPR007087;IPR015880 195828 zinc finger protein 367 [Source:HGNC Symbol;Acc:HGNC:18320] None Full not tested None None c Yes No Yes 4a, two or more datasets predict it as a TF Sam Lambert Arttu Jolma No $#ENSG00000165244#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:15344908 $#ENSP00000364405#ENSG00000165244#ENST00000375256#C2H2 ZF Containing Proteins# FALSE 616 ENSG00000075407 ZNF37A C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 7587 zinc finger protein 37A [Source:HGNC Symbol;Acc:HGNC:13102] None DBD and Full not tested None None a Yes No Yes 1a1, Direct HQ evidence Jussi Taipale Tim Hughes Yes $#ENSG00000075407#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 | NAS - PMID:8464732 $#ENSP00000329141#ENSG00000075407#ENST00000351773#C2H2 ZF Containing Proteins#KRAB$#ENSP00000354377#ENSG00000075407#ENST00000361085#C2H2 ZF Containing Proteins#KRAB$#ENSP00000490669#ENSG00000075407#ENST00000638053#C2H2 ZF Containing Proteins#KRAB TRUE 617 ENSG00000161298 ZNF382 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 84911 zinc finger protein 382 [Source:HGNC Symbol;Acc:HGNC:17409] None DBD and Full not tested None None b Yes No Yes 1a1, Direct HQ evidence Sam Lambert Laura Campitelli Yes $#ENSG00000161298#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000292928#ENSG00000161298#ENST00000292928#C2H2 ZF Containing Proteins#KRAB$#ENSP00000389722#ENSG00000161298#ENST00000423582#C2H2 ZF Containing Proteins#$#ENSP00000410113#ENSG00000161298#ENST00000435416#C2H2 ZF Containing Proteins#KRAB$#ENSP00000407593#ENSG00000161298#ENST00000439428#C2H2 ZF Containing Proteins#KRAB$#ENSP00000467675#ENSG00000161298#ENST00000460670#C2H2 ZF Containing Proteins#KRAB$#ENSP00000465485#ENSG00000161298#ENST00000590785#C2H2 ZF Containing Proteins# TRUE 618 ENSG00000188283 ZNF383 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 163087 zinc finger protein 383 [Source:HGNC Symbol;Acc:HGNC:18609] None Full not tested None None b Yes No Yes 1a1, Direct HQ evidence Laura Campitelli Jussi Taipale Yes $#ENSG00000188283#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000340132#ENSG00000188283#ENST00000352998#C2H2 ZF Containing Proteins#KRAB$#ENSP00000464871#ENSG00000188283#ENST00000589413#C2H2 ZF Containing Proteins#KRAB$#ENSP00000465246#ENSG00000188283#ENST00000588371#C2H2 ZF Containing Proteins#KRAB$#ENSP00000466101#ENSG00000188283#ENST00000590503#C2H2 ZF Containing Proteins#KRAB TRUE 619 ENSG00000126746 ZNF384 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR007087;IPR015880 171017 zinc finger protein 384 [Source:HGNC Symbol;Acc:HGNC:11955] None DBD and Full not tested None None a Yes No No 1a1, Direct HQ evidence Sam Lambert Arttu Jolma Yes None $#ENSP00000348018#ENSG00000126746#ENST00000355772#C2H2 ZF Containing Proteins#$#ENSP00000321650#ENSG00000126746#ENST00000319770#C2H2 ZF Containing Proteins#$#ENSP00000380019#ENSG00000126746#ENST00000396801#C2H2 ZF Containing Proteins#$#ENSP00000439736#ENSG00000126746#ENST00000540915#C2H2 ZF Containing Proteins#$#ENSP00000412911#ENSG00000126746#ENST00000436774#C2H2 ZF Containing Proteins#$#ENSP00000437488#ENSG00000126746#ENST00000535485#C2H2 ZF Containing Proteins#$#ENSP00000473311#ENSG00000126746#ENST00000545946#C2H2 ZF Containing Proteins#Med15, Pex14_N FALSE 620 ENSG00000161642 ZNF385A C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR003604;IPR007087;IPR015880; 25946 zinc finger protein 385A [Source:HGNC Symbol;Acc:HGNC:17521] None Full not tested None None a Yes No No 4a, two or more datasets predict it as a TF Jussi Taipale Laura Campitelli No None $#ENSP00000338927#ENSG00000161642#ENST00000338010#C2H2 ZF Containing Proteins#AKAP95, zf-C2H2_2, zf-C2H2_jaz, zf-U1, zf-met$#ENSP00000377849#ENSG00000161642#ENST00000394313#C2H2 ZF Containing Proteins#AKAP95, zf-C2H2_2, zf-C2H2_jaz, zf-U1, zf-met$#ENSP00000446913#ENSG00000161642#ENST00000546970#C2H2 ZF Containing Proteins#AKAP95, zf-C2H2_2, zf-C2H2_jaz, zf-U1, zf-met$#ENSP00000447162#ENSG00000161642#ENST00000551771#C2H2 ZF Containing Proteins#$#ENSP00000293385#ENSG00000161642#ENST00000352268#C2H2 ZF Containing Proteins# FALSE 621 ENSG00000144331 ZNF385B C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR003604;IPR007087;IPR015880; 151126 zinc finger protein 385B [Source:HGNC Symbol;Acc:HGNC:26332] None Full not tested None None b Yes No No 4a, two or more datasets predict it as a TF Sam Lambert Jussi Taipale No None $#ENSP00000386845#ENSG00000144331#ENST00000410066#C2H2 ZF Containing Proteins#AKAP95, zf-C2H2_2, zf-C2H2_jaz, zf-DBF, zf-U1, zf-$#ENSP00000386379#ENSG00000144331#ENST00000409343#C2H2 ZF Containing Proteins#$#ENSP00000400232#ENSG00000144331#ENST00000438871#C2H2 ZF Containing Proteins#$#ENSP00000409978#ENSG00000144331#ENST00000451732#C2H2 ZF Containing Proteins#zf-C2H2_jaz, zf-met FALSE 622 ENSG00000187595 ZNF385C C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR003604;IPR007087;IPR015880; 201181 zinc finger protein 385C [Source:HGNC Symbol;Acc:HGNC:33722] None Full not tested None None c No No No 5a, one of the source datasets predicts is as a TF Arttu Jolma Jussi Taipale No None $#ENSP00000411514#ENSG00000187595#ENST00000436535#C2H2 ZF Containing Proteins#zf-C2H2_jaz, zf-U1, zf-met$#ENSP00000480744#ENSG00000187595#ENST00000618554#C2H2 ZF Containing Proteins# FALSE 623 ENSG00000151789 ZNF385D C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR003604;IPR007087;IPR015880; 79750 zinc finger protein 385D [Source:HGNC Symbol;Acc:HGNC:26191] None DBD and Full not tested None None b Yes No No 1a1, Direct HQ evidence Sam Lambert Laura Campitelli No None $#ENSP00000281523#ENSG00000151789#ENST00000281523#C2H2 ZF Containing Proteins# FALSE 624 ENSG00000124613 ZNF391 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR007087;IPR015880 346157 zinc finger protein 391 [Source:HGNC Symbol;Acc:HGNC:18779] None Full not tested None None c Yes No Yes 4a, two or more datasets predict it as a TF Sam Lambert Laura Campitelli Yes $#ENSG00000124613#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000244576#ENSG00000124613#ENST00000244576#C2H2 ZF Containing Proteins#$#ENSP00000419498#ENSG00000124613#ENST00000461521#C2H2 ZF Containing Proteins# FALSE 625 ENSG00000160908 ZNF394 C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect None IPR001909;IPR003309;IPR007087;IPR008916;IPR015880; 84124 zinc finger protein 394 [Source:HGNC Symbol;Acc:HGNC:18832] None DBD and Full not tested None None b Yes No Yes 1a1, Direct HQ evidence Arttu Jolma Pratyush Das Yes $#ENSG00000160908#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000337363#ENSG00000160908#ENST00000337673#C2H2 ZF Containing Proteins#KRAB, SCAN$#ENSP00000409565#ENSG00000160908#ENST00000426306#C2H2 ZF Containing Proteins#SCAN TRUE 626 ENSG00000186918 ZNF395 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif Single C2H2 domain Contains a single ZF (string matching on Uniprot) that is not identified using Pfam HMM thresholds. Shown to bind a short DNA sequence (GCCGGCG) by EMSA and DNase I footprinting (PMID:14625278). IPR007087; 55893 zinc finger protein 395 [Source:HGNC Symbol;Acc:HGNC:18737] None DBD and Full not tested None None a No No No 5a, one of the source datasets predicts is as a TF Laura Campitelli Sam Lambert No None $#ENSP00000340494#ENSG00000186918#ENST00000344423#C2H2 ZF Containing Proteins#DUF4772, FOXP-CC$#ENSP00000428452#ENSG00000186918#ENST00000523095#C2H2 ZF Containing Proteins#DUF4772, FOXP-CC$#ENSP00000429640#ENSG00000186918#ENST00000523202#C2H2 ZF Containing Proteins#DUF4772, FOXP-CC$#ENSP00000429649#ENSG00000186918#ENST00000517459#C2H2 ZF Containing Proteins#DUF4772$#ENSP00000427934#ENSG00000186918#ENST00000521912#C2H2 ZF Containing Proteins#DUF4772$#ENSP00000429823#ENSG00000186918#ENST00000522795#C2H2 ZF Containing Proteins#DUF4772 FALSE 627 ENSG00000186496 ZNF396 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR003309;IPR007087;IPR008916;IPR015880 252884 zinc finger protein 396 [Source:HGNC Symbol;Acc:HGNC:18824] None DBD and Full not tested None None a Yes No Yes 1a1, Direct HQ evidence Jussi Taipale Laura Campitelli Yes $#ENSG00000186496#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000302310#ENSG00000186496#ENST00000306346#C2H2 ZF Containing Proteins#SCAN$#ENSP00000467275#ENSG00000186496#ENST00000586687#C2H2 ZF Containing Proteins#SCAN$#ENSP00000466500#ENSG00000186496#ENST00000589332#C2H2 ZF Containing Proteins#SCAN$#ENSP00000468381#ENSG00000186496#ENST00000585522#C2H2 ZF Containing Proteins#SCAN FALSE 628 ENSG00000186812 ZNF397 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains and that it binds on centromeric regions PMID: 18369653 IPR003309;IPR007087;IPR008916;IPR015880 84307 zinc finger protein 397 [Source:HGNC Symbol;Acc:HGNC:18818] None DBD and Full not tested None None b Yes No Yes 4a, two or more datasets predict it as a TF Jussi Taipale Arttu Jolma Yes $#ENSG00000186812#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000261333#ENSG00000186812#ENST00000261333#C2H2 ZF Containing Proteins#SCAN$#ENSP00000331577#ENSG00000186812#ENST00000330501#C2H2 ZF Containing Proteins#SCAN$#ENSP00000466317#ENSG00000186812#ENST00000591206#C2H2 ZF Containing Proteins#SCAN$#ENSP00000464808#ENSG00000186812#ENST00000588119#C2H2 ZF Containing Proteins#SCAN$#ENSP00000468413#ENSG00000186812#ENST00000592264#C2H2 ZF Containing Proteins#SCAN FALSE 629 ENSG00000197024 ZNF398 C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect None IPR001909;IPR007087;IPR015880;IPR022137 57541 zinc finger protein 398 [Source:HGNC Symbol;Acc:HGNC:18373] None Full not tested None None a Yes No No 1a1, Direct HQ evidence Arttu Jolma Sam Lambert Yes None $#ENSP00000389972#ENSG00000197024#ENST00000426851#C2H2 ZF Containing Proteins#$#ENSP00000420418#ENSG00000197024#ENST00000475153#C2H2 ZF Containing Proteins#DUF3669, KRAB$#ENSP00000419391#ENSG00000197024#ENST00000491174#C2H2 ZF Containing Proteins#$#ENSP00000418564#ENSG00000197024#ENST00000483892#C2H2 ZF Containing Proteins# TRUE 630 ENSG00000176222 ZNF404 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains and a KRAB-domain IPR001909;IPR007087;IPR015880; 342908 zinc finger protein 404 [Source:HGNC Symbol;Acc:HGNC:19417] None DBD and Full not tested None None b Yes No No 4a, two or more datasets predict it as a TF Arttu Jolma Pratyush Das Yes None $#ENSP00000319479#ENSG00000176222#ENST00000324394#C2H2 ZF Containing Proteins#KRAB$#ENSP00000466051#ENSG00000176222#ENST00000587539#C2H2 ZF Containing Proteins#KRAB TRUE 631 ENSG00000215421 ZNF407 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif Has a putative AT-hook Protein has a decent cassette of znfC2H2 domains; a study links it in regulation of glucose intake receptor GLUT4 (PMID: 25596527). IPR003604;IPR007087;IPR015880; 55628 zinc finger protein 407 [Source:HGNC Symbol;Acc:HGNC:19904] None not tested not tested None None b Yes No No 4a, two or more datasets predict it as a TF Pratyush Das Arttu Jolma Yes None $#ENSP00000299687#ENSG00000215421#ENST00000299687#C2H2 ZF Containing Proteins#zf-C2H2_4, zf-H2C2_2, zf-H2C2_5, zf-met$#ENSP00000310359#ENSG00000215421#ENST00000309902#C2H2 ZF Containing Proteins#zf-C2H2_2, zf-C2H2_4, zf-H2C2_2, zf-H2C2_5, zf-met$#ENSP00000463270#ENSG00000215421#ENST00000577538#C2H2 ZF Containing Proteins#zf-C2H2_4, zf-H2C2_2, zf-H2C2_5, zf-met$#ENSP00000481798#ENSG00000215421#ENST00000584235#C2H2 ZF Containing Proteins# FALSE 632 ENSG00000175213 ZNF408 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR007087;IPR015880 79797 zinc finger protein 408 [Source:HGNC Symbol;Acc:HGNC:20041] None Full not tested None None b Yes No No 4a, two or more datasets predict it as a TF Yimeng Yin Laura Campitelli Yes None $#ENSP00000309606#ENSG00000175213#ENST00000311764#C2H2 ZF Containing Proteins# FALSE 633 ENSG00000147124 ZNF41 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 7592 zinc finger protein 41 [Source:HGNC Symbol;Acc:HGNC:13107] None Full not tested None None b Yes No No 1a1, Direct HQ evidence Laura Campitelli Arttu Jolma Yes $#ENSG00000147124#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000315173#ENSG00000147124#ENST00000313116#C2H2 ZF Containing Proteins#KRAB$#ENSP00000366265#ENSG00000147124#ENST00000377065#C2H2 ZF Containing Proteins#KRAB$#ENSP00000390385#ENSG00000147124#ENST00000432977#C2H2 ZF Containing Proteins#KRAB TRUE 634 ENSG00000119725 ZNF410 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR007087;IPR015880 57862 zinc finger protein 410 [Source:HGNC Symbol;Acc:HGNC:20144] None DBD and Full not tested None None a Yes No No 1a1, Direct HQ evidence Jussi Taipale Arttu Jolma Yes None $#ENSP00000323293#ENSG00000119725#ENST00000324593#C2H2 ZF Containing Proteins#$#ENSP00000407130#ENSG00000119725#ENST00000442160#C2H2 ZF Containing Proteins#$#ENSP00000451763#ENSG00000119725#ENST00000555044#C2H2 ZF Containing Proteins#$#ENSP00000442228#ENSG00000119725#ENST00000540593#C2H2 ZF Containing Proteins#$#ENSP00000451116#ENSG00000119725#ENST00000554797#C2H2 ZF Containing Proteins#$#ENSP00000451073#ENSG00000119725#ENST00000556797#C2H2 ZF Containing Proteins#$#ENSP00000451748#ENSG00000119725#ENST00000554316#C2H2 ZF Containing Proteins#$#ENSP00000451620#ENSG00000119725#ENST00000557214#C2H2 ZF Containing Proteins# FALSE 635 ENSG00000133250 ZNF414 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Its on the low end of confidence that its a TF; since most of the domains are variants of C2H2; but its more likely than not since they are in a row. IPR007087;IPR015880 84330 zinc finger protein 414 [Source:HGNC Symbol;Acc:HGNC:20630] None DBD and Full not tested None None b Yes No No 4a, two or more datasets predict it as a TF Pratyush Das Tim Hughes Yes None $#ENSP00000255616#ENSG00000133250#ENST00000255616#C2H2 ZF Containing Proteins#$#ENSP00000377504#ENSG00000133250#ENST00000393927#C2H2 ZF Containing Proteins#zf-H2C2_5$#ENSP00000471378#ENSG00000133250#ENST00000596772#C2H2 ZF Containing Proteins#zf-H2C2_5$#ENSP00000473079#ENSG00000133250#ENST00000593661#C2H2 ZF Containing Proteins#zf-C2H2_8$#ENSP00000471863#ENSG00000133250#ENST00000594748#C2H2 ZF Containing Proteins#zf-C2H2_8 FALSE 636 ENSG00000170954 ZNF415 C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect None IPR001909;IPR003656;IPR007087;IPR015880 55786 Zinc finger protein 415 [Source:HGNC Symbol;Acc:HGNC:20636] None Full not tested None None b Yes No No 1a1, Direct HQ evidence Yimeng Yin Laura Campitelli Yes $#ENSG00000170954#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000243643#ENSG00000170954#ENST00000243643#C2H2 ZF Containing Proteins#KRAB$#ENSP00000472911#ENSG00000170954#ENST00000601493#C2H2 ZF Containing Proteins#$#ENSP00000472584#ENSG00000170954#ENST00000594011#C2H2 ZF Containing Proteins#KRAB$#ENSP00000472516#ENSG00000170954#ENST00000595193#C2H2 ZF Containing Proteins#KRAB$#ENSP00000468917#ENSG00000170954#ENST00000597503#C2H2 ZF Containing Proteins#KRAB$#ENSP00000473008#ENSG00000170954#ENST00000596051#C2H2 ZF Containing Proteins#KRAB$#ENSP00000471167#ENSG00000170954#ENST00000599261#C2H2 ZF Containing Proteins#KRAB$#ENSP00000469483#ENSG00000170954#ENST00000600574#C2H2 ZF Containing Proteins#KRAB$#ENSP00000470410#ENSG00000170954#ENST00000601110#C2H2 ZF Containing Proteins#KRAB FALSE 637 ENSG00000083817 ZNF416 C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source None None IPR001909;IPR007087;IPR015880; 55659 zinc finger protein 416 [Source:HGNC Symbol;Acc:HGNC:20645] None Full not tested None None b Yes No No 1a1, Direct HQ evidence Laura Campitelli Jussi Taipale Yes None $#ENSP00000196489#ENSG00000083817#ENST00000196489#C2H2 ZF Containing Proteins#KRAB TRUE 638 ENSG00000173480 ZNF417 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 147687 zinc finger protein 417 [Source:HGNC Symbol;Acc:HGNC:20646] None Full not tested None None b Yes No No 1a1, Direct HQ evidence Sam Lambert Pratyush Das Yes None $#ENSP00000311319#ENSG00000173480#ENST00000312026#C2H2 ZF Containing Proteins#KRAB, zf-C2H2_4$#ENSP00000472272#ENSG00000173480#ENST00000595559#C2H2 ZF Containing Proteins#KRAB, zf-C2H2_4$#ENSP00000471471#ENSG00000173480#ENST00000598629#C2H2 ZF Containing Proteins#$#ENSP00000472352#ENSG00000173480#ENST00000594396#C2H2 ZF Containing Proteins#KRAB$#ENSP00000471325#ENSG00000173480#ENST00000598526#C2H2 ZF Containing Proteins# TRUE 639 ENSG00000196724 ZNF418 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 147686 zinc finger protein 418 [Source:HGNC Symbol;Acc:HGNC:20647] None DBD and Full not tested None None b Yes No Yes 1a1, Direct HQ evidence Pratyush Das Arttu Jolma Yes $#ENSG00000196724#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000379451#ENSG00000196724#ENST00000396147#C2H2 ZF Containing Proteins#KRAB, zf-C2H2_4$#ENSP00000471652#ENSG00000196724#ENST00000595830#C2H2 ZF Containing Proteins#KRAB, zf-C2H2_4$#ENSP00000483763#ENSG00000196724#ENST00000616958#C2H2 ZF Containing Proteins#KRAB, zf-C2H2_4$#ENSP00000407039#ENSG00000196724#ENST00000425570#C2H2 ZF Containing Proteins#KRAB, zf-C2H2_4$#ENSP00000468968#ENSG00000196724#ENST00000599852#C2H2 ZF Containing Proteins#zf-H2C2_2 TRUE 640 ENSG00000105136 ZNF419 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 79744 zinc finger protein 419 [Source:HGNC Symbol;Acc:HGNC:20648] None DBD and Full not tested None None b Yes No Yes 1a1, Direct HQ evidence Jussi Taipale Pratyush Das Yes $#ENSG00000105136#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000221735#ENSG00000105136#ENST00000221735#C2H2 ZF Containing Proteins#FAM178, KRAB$#ENSP00000388864#ENSG00000105136#ENST00000424930#C2H2 ZF Containing Proteins#FAM178, KRAB$#ENSP00000299860#ENSG00000105136#ENST00000347466#C2H2 ZF Containing Proteins#FAM178, KRAB$#ENSP00000392129#ENSG00000105136#ENST00000415379#C2H2 ZF Containing Proteins#FAM178, KRAB$#ENSP00000390916#ENSG00000105136#ENST00000426954#C2H2 ZF Containing Proteins#FAM178, KRAB$#ENSP00000414709#ENSG00000105136#ENST00000442920#C2H2 ZF Containing Proteins#FAM178, KRAB$#ENSP00000427723#ENSG00000105136#ENST00000518999#C2H2 ZF Containing Proteins#KRAB$#ENSP00000429504#ENSG00000105136#ENST00000523138#C2H2 ZF Containing Proteins#KRAB$#ENSP00000428181#ENSG00000105136#ENST00000523882#C2H2 ZF Containing Proteins#KRAB TRUE 641 ENSG00000197050 ZNF420 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR001909;IPR007087;IPR015880; 147923 zinc finger protein 420 [Source:HGNC Symbol;Acc:HGNC:20649] None Full not tested None None b Yes No Yes 4a, two or more datasets predict it as a TF Laura Campitelli Sam Lambert Yes $#ENSG00000197050#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000338770#ENSG00000197050#ENST00000337995#C2H2 ZF Containing Proteins#KRAB$#ENSP00000306102#ENSG00000197050#ENST00000304239#C2H2 ZF Containing Proteins#KRAB$#ENSP00000468736#ENSG00000197050#ENST00000585862#C2H2 ZF Containing Proteins# TRUE 642 ENSG00000102935 ZNF423 C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain None IPR007087;IPR015880 23090 zinc finger protein 423 [Source:HGNC Symbol;Acc:HGNC:16762] None Full not tested None None b Yes TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:9151733;9774661 No 2a1, Lower confidence direct evidence Yimeng Yin Tim Hughes Yes None $#ENSP00000262383#ENSG00000102935#ENST00000262383#C2H2 ZF Containing Proteins#zf-C2H2_2, zf-C2H2_4, zf-C2H2_6, zf-C2H2_jaz, zf-D$#ENSP00000457664#ENSG00000102935#ENST00000562520#C2H2 ZF Containing Proteins#zf-C2H2_2, zf-C2H2_4, zf-C2H2_6, zf-C2H2_jaz, zf-D$#ENSP00000455061#ENSG00000102935#ENST00000567169#C2H2 ZF Containing Proteins#zf-C2H2_2, zf-C2H2_4, zf-C2H2_6, zf-C2H2_jaz, zf-D$#ENSP00000442321#ENSG00000102935#ENST00000535559#C2H2 ZF Containing Proteins#zf-C2H2_2, zf-C2H2_4, zf-C2H2_6, zf-C2H2_jaz, zf-D$#ENSP00000479288#ENSG00000102935#ENST00000568094#C2H2 ZF Containing Proteins#C1_4, Zn-ribbon_8, zf-C2H2_4 FALSE 643 ENSG00000204947 ZNF425 C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect None IPR001909;IPR007087;IPR015880; 155054 zinc finger protein 425 [Source:HGNC Symbol;Acc:HGNC:20690] None Full not tested None None b Yes No No 1a1, Direct HQ evidence Yimeng Yin Pratyush Das Yes None $#ENSP00000367300#ENSG00000204947#ENST00000378061#C2H2 ZF Containing Proteins#KRAB$#ENSP00000420379#ENSG00000204947#ENST00000483014#C2H2 ZF Containing Proteins#KRAB TRUE 644 ENSG00000130818 ZNF426 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR001909;IPR003656;IPR007087;IPR015880 79088 zinc finger protein 426 [Source:HGNC Symbol;Acc:HGNC:20725] None DBD and Full Yes None None b Yes No No 4a, two or more datasets predict it as a TF Laura Campitelli Sam Lambert Yes None $#ENSP00000253115#ENSG00000130818#ENST00000253115#C2H2 ZF Containing Proteins#KRAB$#ENSP00000439017#ENSG00000130818#ENST00000535489#C2H2 ZF Containing Proteins#KRAB$#ENSP00000468100#ENSG00000130818#ENST00000593003#C2H2 ZF Containing Proteins#KRAB$#ENSP00000466469#ENSG00000130818#ENST00000589289#C2H2 ZF Containing Proteins#KRAB TRUE 645 ENSG00000131116 ZNF428 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif Single C2H2 domain None IPR007087; 126299 zinc finger protein 428 [Source:HGNC Symbol;Acc:HGNC:20804] None Full not tested None None c No No No 5a, one of the source datasets predicts is as a TF Arttu Jolma Sam Lambert No None $#ENSP00000300811#ENSG00000131116#ENST00000300811#C2H2 ZF Containing Proteins#$#ENSP00000469484#ENSG00000131116#ENST00000598676#C2H2 ZF Containing Proteins# FALSE 646 ENSG00000197013 ZNF429 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 353088 zinc finger protein 429 [Source:HGNC Symbol;Acc:HGNC:20817] None not tested not tested None None c Yes No Yes 1a1, Direct HQ evidence Pratyush Das Yimeng Yin Yes $#ENSG00000197013#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000469739#ENSG00000197013#ENST00000594385#C2H2 ZF Containing Proteins#$#ENSP00000470300#ENSG00000197013#ENST00000597078#C2H2 ZF Containing Proteins#KRAB$#ENSP00000351280#ENSG00000197013#ENST00000358491#C2H2 ZF Containing Proteins#KRAB$#ENSP00000479286#ENSG00000197013#ENST00000618549#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2 TRUE 647 ENSG00000198521 ZNF43 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR001909;IPR007087;IPR015880; 7594 zinc finger protein 43 [Source:HGNC Symbol;Acc:HGNC:13109] None Full not tested None None a Yes No No 4a, two or more datasets predict it as a TF Sam Lambert Laura Campitelli Yes None $##ENSG00000198521##C2H2 ZF Containing Proteins# TRUE 648 ENSG00000118620 ZNF430 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 80264 zinc finger protein 430 [Source:HGNC Symbol;Acc:HGNC:20808] None DBD and Full not tested None None b Yes No No 1a1, Direct HQ evidence Tim Hughes Pratyush Das Yes None $#ENSP00000261560#ENSG00000118620#ENST00000261560#C2H2 ZF Containing Proteins#KRAB$#ENSP00000469148#ENSG00000118620#ENST00000595401#C2H2 ZF Containing Proteins#KRAB$#ENSP00000473069#ENSG00000118620#ENST00000594110#C2H2 ZF Containing Proteins#KRAB$#ENSP00000469787#ENSG00000118620#ENST00000597922#C2H2 ZF Containing Proteins# TRUE 649 ENSG00000196705 ZNF431 C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect None IPR001909;IPR007087;IPR015880; 170959 zinc finger protein 431 [Source:HGNC Symbol;Acc:HGNC:20809] None Full not tested None None b Yes No Yes 1a1, Direct HQ evidence Jussi Taipale Arttu Jolma Yes $#ENSG00000196705#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024 $#ENSP00000308578#ENSG00000196705#ENST00000311048#C2H2 ZF Containing Proteins#KRAB$#ENSP00000469460#ENSG00000196705#ENST00000594425#C2H2 ZF Containing Proteins# TRUE 650 ENSG00000256087 ZNF432 C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect None IPR001909;IPR007087;IPR015880; 9668 zinc finger protein 614 [Source:HGNC Symbol;Acc:HGNC:24722] None DBD and Full not tested None None b Yes No Yes 1a1, Direct HQ evidence Sam Lambert Arttu Jolma Yes $#ENSG00000256087#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000221315#ENSG00000256087#ENST00000221315#C2H2 ZF Containing Proteins#KRAB$#ENSP00000470488#ENSG00000256087#ENST00000594154#C2H2 ZF Containing Proteins#KRAB$#ENSP00000470341#ENSG00000256087#ENST00000597273#C2H2 ZF Containing Proteins#KRAB TRUE 651 ENSG00000197647 ZNF433 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 163059 zinc finger protein 433 [Source:HGNC Symbol;Acc:HGNC:20811] None DBD and Full not tested None None b Yes No No 1a1, Direct HQ evidence Sam Lambert Jussi Taipale Yes None $#ENSP00000393416#ENSG00000197647#ENST00000419886#C2H2 ZF Containing Proteins#$#ENSP00000447951#ENSG00000197647#ENST00000478765#C2H2 ZF Containing Proteins#KRAB$#ENSP00000339767#ENSG00000197647#ENST00000344980#C2H2 ZF Containing Proteins#KRAB$#ENSP00000448099#ENSG00000197647#ENST00000550507#C2H2 ZF Containing Proteins#KRAB$#ENSP00000448806#ENSG00000197647#ENST00000547560#C2H2 ZF Containing Proteins#$#ENSP00000447205#ENSG00000197647#ENST00000550745#C2H2 ZF Containing Proteins#KRAB TRUE 652 ENSG00000125945 ZNF436 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 80818 zinc finger protein 436 [Source:HGNC Symbol;Acc:HGNC:20814] None DBD and Full not tested None None b Yes No Yes 1a1, Direct HQ evidence Tim Hughes Jussi Taipale Yes $#ENSG00000125945#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000313582#ENSG00000125945#ENST00000314011#C2H2 ZF Containing Proteins#KRAB$#ENSP00000363736#ENSG00000125945#ENST00000374608#C2H2 ZF Containing Proteins#KRAB TRUE 653 ENSG00000183621 ZNF438 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Virtually nothing is known for this protein except that it has two znfC2H2 domains and that it represses transcription in a reporter assay PMID: 17669267 IPR007087;IPR015880 220929 zinc finger protein 438 [Source:HGNC Symbol;Acc:HGNC:21029] None DBD and Full not tested None None b Yes No Yes 4a, two or more datasets predict it as a TF Arttu Jolma Yimeng Yin Yes None $#ENSP00000333571#ENSG00000183621#ENST00000331737#C2H2 ZF Containing Proteins#zf-C2H2_4$#ENSP00000354663#ENSG00000183621#ENST00000361310#C2H2 ZF Containing Proteins#zf-C2H2_4$#ENSP00000364460#ENSG00000183621#ENST00000375311#C2H2 ZF Containing Proteins#zf-C2H2_4$#ENSP00000445461#ENSG00000183621#ENST00000538351#C2H2 ZF Containing Proteins#zf-C2H2_4 FALSE 654 ENSG00000171291 ZNF439 C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect None IPR001909;IPR007087;IPR015880; 90594 zinc finger protein 439 [Source:HGNC Symbol;Acc:HGNC:20873] None Full not tested None None b Yes No No 1a1, Direct HQ evidence Yimeng Yin Jussi Taipale Yes None $#ENSP00000305077#ENSG00000171291#ENST00000304030#C2H2 ZF Containing Proteins#KRAB$#ENSP00000395632#ENSG00000171291#ENST00000455282#C2H2 ZF Containing Proteins#$#ENSP00000388234#ENSG00000171291#ENST00000442091#C2H2 ZF Containing Proteins#KRAB TRUE 655 ENSG00000197857 ZNF44 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 51710 zinc finger protein 44 [Source:HGNC Symbol;Acc:HGNC:13110] None Full not tested None None a Yes No No 1a1, Direct HQ evidence Laura Campitelli Pratyush Das Yes None $#ENSP00000347910#ENSG00000197857#ENST00000355684#C2H2 ZF Containing Proteins#KRAB$#ENSP00000348419#ENSG00000197857#ENST00000356109#C2H2 ZF Containing Proteins#KRAB TRUE 656 ENSG00000171295 ZNF440 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 126070 zinc finger protein 440 [Source:HGNC Symbol;Acc:HGNC:20874] None DBD and Full not tested None None b Yes No No 1a1, Direct HQ evidence Jussi Taipale Arttu Jolma Yes None $#ENSP00000305373#ENSG00000171295#ENST00000304060#C2H2 ZF Containing Proteins#KRAB, zf-C2H2_4$#ENSP00000411974#ENSG00000171295#ENST00000414255#C2H2 ZF Containing Proteins#KRAB$#ENSP00000393489#ENSG00000171295#ENST00000427505#C2H2 ZF Containing Proteins#KRAB$#ENSP00000404425#ENSG00000171295#ENST00000457526#C2H2 ZF Containing Proteins# TRUE 657 ENSG00000197044 ZNF441 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 126068 zinc finger protein 441 [Source:HGNC Symbol;Acc:HGNC:20875] None not tested not tested None None b Yes No No 1a1, Direct HQ evidence Sam Lambert Pratyush Das Yes None $#ENSP00000350576#ENSG00000197044#ENST00000357901#C2H2 ZF Containing Proteins#KRAB, Zn-ribbon_8, zf-C2H2_4, zf-C2H2_6, zf-H2C2_2 TRUE 658 ENSG00000198342 ZNF442 C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect None IPR001909;IPR007087;IPR015880; 79973 zinc finger protein 442 [Source:HGNC Symbol;Acc:HGNC:20877] None DBD not tested None None b Yes No No 1a1, Direct HQ evidence Sam Lambert Yimeng Yin Yes None $#ENSP00000242804#ENSG00000198342#ENST00000242804#C2H2 ZF Containing Proteins#KRAB$#ENSP00000388634#ENSG00000198342#ENST00000438182#C2H2 ZF Containing Proteins#$#ENSP00000404935#ENSG00000198342#ENST00000424168#C2H2 ZF Containing Proteins#$#ENSP00000440162#ENSG00000198342#ENST00000545749#C2H2 ZF Containing Proteins#KRAB TRUE 659 ENSG00000180855 ZNF443 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 10224 zinc finger protein 443 [Source:HGNC Symbol;Acc:HGNC:20878] None DBD not tested None None b Yes No No 1a1, Direct HQ evidence Pratyush Das Arttu Jolma Yes None $#ENSP00000301547#ENSG00000180855#ENST00000301547#C2H2 ZF Containing Proteins#KRAB TRUE 660 ENSG00000167685 ZNF444 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR003309;IPR007087;IPR008916;IPR015880 55311 zinc finger protein 444 [Source:HGNC Symbol;Acc:HGNC:16052] None DBD and Full not tested None None a Yes No Yes 1a1, Direct HQ evidence Pratyush Das Yimeng Yin Yes $#ENSG00000167685#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000338860#ENSG00000167685#ENST00000337080#C2H2 ZF Containing Proteins#SCAN$#ENSP00000468069#ENSG00000167685#ENST00000592949#C2H2 ZF Containing Proteins#SCAN$#ENSP00000465171#ENSG00000167685#ENST00000587467#C2H2 ZF Containing Proteins#SCAN$#ENSP00000466287#ENSG00000167685#ENST00000588358#C2H2 ZF Containing Proteins#SCAN$#ENSP00000468762#ENSG00000167685#ENST00000591564#C2H2 ZF Containing Proteins#SCAN$#ENSP00000465070#ENSG00000167685#ENST00000593100#C2H2 ZF Containing Proteins#SCAN FALSE 661 ENSG00000185219 ZNF445 C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect None IPR001909;IPR003309;IPR007087;IPR008916;IPR015880; 353274 zinc finger protein 445 [Source:HGNC Symbol;Acc:HGNC:21018] None Full not tested None None b Yes No No 1a1, Direct HQ evidence Sam Lambert Pratyush Das Yes $#ENSG00000185219#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002 $#ENSP00000379387#ENSG00000185219#ENST00000396077#C2H2 ZF Containing Proteins#KRAB, SCAN, zf-C2H2_4, zf-H2C2_2$#ENSP00000413073#ENSG00000185219#ENST00000425708#C2H2 ZF Containing Proteins#KRAB, SCAN, zf-C2H2_4, zf-H2C2_2$#ENSP00000483454#ENSG00000185219#ENST00000617032#C2H2 ZF Containing Proteins#KRAB, SCAN TRUE 662 ENSG00000083838 ZNF446 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Contains three znfC2H2 domains and represses transcription when expressed as GAL4 fusion (PMID:15936718). IPR001909;IPR003309;IPR007087;IPR008916;IPR015880; 55663 zinc finger protein 446 [Source:HGNC Symbol;Acc:HGNC:21036] None DBD and Full not tested None None b Yes No Yes 4a, two or more datasets predict it as a TF Laura Campitelli Arttu Jolma Yes $#ENSG00000083838#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000472802#ENSG00000083838#ENST00000594369#C2H2 ZF Containing Proteins#KRAB, SCAN$#ENSP00000478778#ENSG00000083838#ENST00000610298#C2H2 ZF Containing Proteins#KRAB, SCAN$#ENSP00000484676#ENSG00000083838#ENST00000622313#C2H2 ZF Containing Proteins#SCAN$#ENSP00000470963#ENSG00000083838#ENST00000600013#C2H2 ZF Containing Proteins#SCAN TRUE 663 ENSG00000173275 ZNF449 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR003309;IPR007087;IPR008916;IPR015880 203523 zinc finger protein 449 [Source:HGNC Symbol;Acc:HGNC:21039] None DBD and Full not tested None None b Yes No Yes 1a1, Direct HQ evidence Pratyush Das Sam Lambert Yes $#ENSG00000173275#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000339585#ENSG00000173275#ENST00000339249#C2H2 ZF Containing Proteins#SCAN$#ENSP00000359797#ENSG00000173275#ENST00000370761#C2H2 ZF Containing Proteins#SCAN FALSE 664 ENSG00000124459 ZNF45 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 7596 zinc finger protein 45 [Source:HGNC Symbol;Acc:HGNC:13111] None not tested not tested None None b Yes No Yes 1a1, Direct HQ evidence Sam Lambert Laura Campitelli Yes $#ENSG00000124459#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:9570955 $#ENSP00000468579#ENSG00000124459#ENST00000589703#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2$#ENSP00000481895#ENSG00000124459#ENST00000615985#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2$#ENSP00000269973#ENSG00000124459#ENST00000269973#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2$#ENSP00000467551#ENSG00000124459#ENST00000588140#C2H2 ZF Containing Proteins# TRUE 665 ENSG00000112200 ZNF451 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR007087;IPR015880;IPR021623; 26036 zinc finger protein 451 [Source:HGNC Symbol;Acc:HGNC:21091] None DBD and Full not tested None None a Yes No Yes 4a, two or more datasets predict it as a TF Sam Lambert Laura Campitelli Yes $#ENSG00000112200#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000350083#ENSG00000112200#ENST00000357489#C2H2 ZF Containing Proteins#zf-C2H2_4$#ENSP00000359740#ENSG00000112200#ENST00000370706#C2H2 ZF Containing Proteins#zf-C2H2_4$#ENSP00000421645#ENSG00000112200#ENST00000491832#C2H2 ZF Containing Proteins#zf-C2H2_4$#ENSP00000359736#ENSG00000112200#ENST00000370702#C2H2 ZF Containing Proteins#$#ENSP00000359742#ENSG00000112200#ENST00000370708#C2H2 ZF Containing Proteins#LAP2alpha$#ENSP00000359744#ENSG00000112200#ENST00000370710#C2H2 ZF Containing Proteins# FALSE 666 ENSG00000178187 ZNF454 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001909;IPR007087;IPR015880; 285676 zinc finger protein 454 [Source:HGNC Symbol;Acc:HGNC:21200] None Full not tested None None b Yes No Yes 1a1, Direct HQ evidence Pratyush Das Yimeng Yin Yes $#ENSG00000178187#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000326249#ENSG00000178187#ENST00000320129#C2H2 ZF Containing Proteins#KRAB$#ENSP00000430354#ENSG00000178187#ENST00000519564#C2H2 ZF Containing Proteins#KRAB TRUE 667 ENSG00000197714 ZNF460 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001909;IPR007087;IPR015880; 10794 zinc finger protein 460 [Source:HGNC Symbol;Acc:HGNC:21628] None DBD and Full not tested None None b Yes No No 1a1, Direct HQ evidence Sam Lambert Jussi Taipale Yes None $#ENSP00000353491#ENSG00000197714#ENST00000360338#C2H2 ZF Containing Proteins#KRAB$#ENSP00000446167#ENSG00000197714#ENST00000537645#C2H2 ZF Containing Proteins#$#ENSP00000471285#ENSG00000197714#ENST00000599602#C2H2 ZF Containing Proteins# TRUE 668 ENSG00000197808 ZNF461 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Protein has a decent cassette of znfC2H2 domains and a KRAB-domain. It has been shown also to operate as a corepressor of NR5A1, where the KRAB-domain ).mediates both the interaction to NR5A1 and to HDAC2 (PMID: 16595694 IPR001909;IPR007087;IPR015880; 92283 zinc finger protein 461 [Source:HGNC Symbol;Acc:HGNC:21629] None DBD not tested None None b Yes No Yes 4a, two or more datasets predict it as a TF Yimeng Yin Arttu Jolma Yes $#ENSG00000197808#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000467931#ENSG00000197808#ENST00000588268#C2H2 ZF Containing Proteins#KRAB, zf-C2H2_4$#ENSP00000353515#ENSG00000197808#ENST00000360357#C2H2 ZF Containing Proteins#KRAB, zf-C2H2_4$#ENSP00000464914#ENSG00000197808#ENST00000592829#C2H2 ZF Containing Proteins#KRAB TRUE 669 ENSG00000148143 ZNF462 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Has many znfC2H2 like domains that are however not in tight arrays but interspersed throughout the sequence IPR007087;IPR015880 58499 zinc finger protein 462 [Source:HGNC Symbol;Acc:HGNC:21684] None Full not tested None None b No No No 5a, one of the source datasets predicts is as a TF Sam Lambert Arttu Jolma Yes None $#ENSP00000277225#ENSG00000148143#ENST00000277225#C2H2 ZF Containing Proteins#zf-H2C2_2, zf-H2C2_5$#ENSP00000405837#ENSG00000148143#ENST00000427098#C2H2 ZF Containing Proteins#zf-H2C2_2, zf-H2C2_5$#ENSP00000397306#ENSG00000148143#ENST00000441147#C2H2 ZF Containing Proteins#zf-C2H2_4, zf-C2H2_6, zf-H2C2_2, zf-H2C2_5$#ENSP00000363818#ENSG00000148143#ENST00000374686#C2H2 ZF Containing Proteins#zf-C2H2_4, zf-C2H2_6, zf-H2C2_2, zf-H2C2_5 FALSE 670 ENSG00000181444 ZNF467 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR007087;IPR015880 168544 zinc finger protein 467 [Source:HGNC Symbol;Acc:HGNC:23154] None Full not tested None None b Yes TF Gene Candidate_Transcription Factor Binding: tf co-factor binding; DNA-Binding: sequence-specific_Co-activation; DNA Binding; TF PPI_PMIDS:12426389 No 1a1, Direct HQ evidence Arttu Jolma Sam Lambert Yes None $#ENSP00000304769#ENSG00000181444#ENST00000302017#C2H2 ZF Containing Proteins#$#ENSP00000418011#ENSG00000181444#ENST00000484747#C2H2 ZF Containing Proteins# FALSE 671 ENSG00000204604 ZNF468 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 90333 zinc finger protein 468 [Source:HGNC Symbol;Acc:HGNC:33105] None Full not tested None None b Yes No No 1a1, Direct HQ evidence Yimeng Yin Arttu Jolma Yes None $#ENSP00000243639#ENSG00000204604#ENST00000243639#C2H2 ZF Containing Proteins#KRAB$#ENSP00000470381#ENSG00000204604#ENST00000595646#C2H2 ZF Containing Proteins#KRAB, zf-C2H2_6, zf-H2C2_2, zf-met$#ENSP00000470717#ENSG00000204604#ENST00000601847#C2H2 ZF Containing Proteins#KRAB$#ENSP00000469779#ENSG00000204604#ENST00000597924#C2H2 ZF Containing Proteins#KRAB TRUE 672 ENSG00000225614 ZNF469 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif Has a putative AT-hook None IPR007087;IPR015880 84627 zinc finger protein 469 [Source:HGNC Symbol;Acc:HGNC:23216] None not tested not tested None None No Yes No No 5a, one of the source datasets predicts is as a TF Sam Lambert Pratyush Das Yes None $#ENSP00000402343#ENSG00000225614#ENST00000437464#C2H2 ZF Containing Proteins#zf-C2H2_4$#ENSP00000456500#ENSG00000225614#ENST00000565624#C2H2 ZF Containing Proteins#zf-C2H2_4 FALSE 673 ENSG00000197016 ZNF470 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Has a possible role in chondrocytes (PMID: 15302581). It has a decent cassette of znfC2H2 domains and a KRAB-domain. IPR001909;IPR007087;IPR015880; 388566 zinc finger protein 470 [Source:HGNC Symbol;Acc:HGNC:22220] None not tested not tested None None b Yes No Yes 4a, two or more datasets predict it as a TF Sam Lambert Arttu Jolma Yes $#ENSG00000197016#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000333223#ENSG00000197016#ENST00000330619#C2H2 ZF Containing Proteins#KRAB$#ENSP00000375590#ENSG00000197016#ENST00000391709#C2H2 ZF Containing Proteins#KRAB$#ENSP00000471379#ENSG00000197016#ENST00000601902#C2H2 ZF Containing Proteins#KRAB$#ENSP00000472891#ENSG00000197016#ENST00000594953#C2H2 ZF Containing Proteins# TRUE 674 ENSG00000196263 ZNF471 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR001909;IPR007087;IPR015880; 57573 zinc finger protein 471 [Source:HGNC Symbol;Acc:HGNC:23226] None Full not tested None None b Yes No Yes 4a, two or more datasets predict it as a TF Sam Lambert Laura Campitelli Yes $#ENSG00000196263#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000309161#ENSG00000196263#ENST00000308031#C2H2 ZF Containing Proteins#KRAB$#ENSP00000466224#ENSG00000196263#ENST00000591537#C2H2 ZF Containing Proteins#KRAB$#ENSP00000467570#ENSG00000196263#ENST00000591759#C2H2 ZF Containing Proteins#KRAB TRUE 675 ENSG00000142528 ZNF473 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR001909;IPR007087;IPR015880; 25888 zinc finger protein 473 [Source:HGNC Symbol;Acc:HGNC:23239] None DBD and Full not tested None None b Yes No No 5a, one of the source datasets predicts is as a TF Arttu Jolma Yimeng Yin No None $#ENSP00000270617#ENSG00000142528#ENST00000270617#C2H2 ZF Containing Proteins#KRAB, zf-C2H2_4, zf-C2H2_6, zf-H2C2_2$#ENSP00000375697#ENSG00000142528#ENST00000391821#C2H2 ZF Containing Proteins#KRAB, zf-C2H2_4, zf-C2H2_6, zf-H2C2_2$#ENSP00000388961#ENSG00000142528#ENST00000445728#C2H2 ZF Containing Proteins#KRAB, zf-C2H2_4, zf-C2H2_6, zf-H2C2_2$#ENSP00000471595#ENSG00000142528#ENST00000601364#C2H2 ZF Containing Proteins#KRAB TRUE 676 ENSG00000164185 ZNF474 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif Single C2H2 domain None IPR007087; 133923 zinc finger protein 474 [Source:HGNC Symbol;Acc:HGNC:23245] None DBD and Full not tested None None b No No No 5a, one of the source datasets predicts is as a TF Sam Lambert Arttu Jolma No None $#ENSP00000296600#ENSG00000164185#ENST00000296600#C2H2 ZF Containing Proteins#zf-C2H2_4, zf-C2HC_2$#ENSP00000422285#ENSG00000164185#ENST00000504912#C2H2 ZF Containing Proteins#$#ENSP00000424794#ENSG00000164185#ENST00000505843#C2H2 ZF Containing Proteins# FALSE 677 ENSG00000185177 ZNF479 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 90827 zinc finger protein 479 [Source:HGNC Symbol;Acc:HGNC:23258] None not tested not tested None None b Yes No No 1a1, Direct HQ evidence Arttu Jolma Jussi Taipale Yes None $#ENSP00000333776#ENSG00000185177#ENST00000331162#C2H2 ZF Containing Proteins#KRAB$#ENSP00000324518#ENSG00000185177#ENST00000319636#C2H2 ZF Containing Proteins#KRAB$#ENSP00000478005#ENSG00000185177#ENST00000620639#C2H2 ZF Containing Proteins#KRAB TRUE 678 ENSG00000180035 ZNF48 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR007087;IPR015880 197407 zinc finger protein 48 [Source:HGNC Symbol;Acc:HGNC:13114] None DBD Yes None None b Yes No No 4a, two or more datasets predict it as a TF Sam Lambert Yimeng Yin Yes None $#ENSP00000324056#ENSG00000180035#ENST00000320159#C2H2 ZF Containing Proteins#$#ENSP00000432548#ENSG00000180035#ENST00000524644#C2H2 ZF Containing Proteins#$#ENSP00000480262#ENSG00000180035#ENST00000613509#C2H2 ZF Containing Proteins# FALSE 679 ENSG00000198464 ZNF480 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 147657 zinc finger protein 480 [Source:HGNC Symbol;Acc:HGNC:23305] None DBD not tested None None b Yes No Yes 1a1, Direct HQ evidence Laura Campitelli Sam Lambert Yes $#ENSG00000198464#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000471754#ENSG00000198464#ENST00000595962#C2H2 ZF Containing Proteins#KRAB$#ENSP00000334164#ENSG00000198464#ENST00000334564#C2H2 ZF Containing Proteins#KRAB$#ENSP00000418618#ENSG00000198464#ENST00000490272#C2H2 ZF Containing Proteins#$#ENSP00000335670#ENSG00000198464#ENST00000335090#C2H2 ZF Containing Proteins# TRUE 680 ENSG00000173258 ZNF483 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR003309;IPR007087;IPR008916;IPR015880; 158399 zinc finger protein 483 [Source:HGNC Symbol;Acc:HGNC:23384] None Full not tested None None b Yes No Yes 1a1, Direct HQ evidence Laura Campitelli Sam Lambert Yes $#ENSG00000173258#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000311679#ENSG00000173258#ENST00000309235#C2H2 ZF Containing Proteins#KRAB, SCAN$#ENSP00000438048#ENSG00000173258#ENST00000355824#C2H2 ZF Containing Proteins#KRAB, SCAN$#ENSP00000350871#ENSG00000173258#ENST00000358151#C2H2 ZF Containing Proteins#KRAB, SCAN$#ENSP00000363494#ENSG00000173258#ENST00000374374#C2H2 ZF Containing Proteins#SCAN TRUE 681 ENSG00000127081 ZNF484 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 83744 zinc finger protein 484 [Source:HGNC Symbol;Acc:HGNC:23385] None DBD and Full not tested None None b Yes No Yes 1a1, Direct HQ evidence Tim Hughes Sam Lambert Yes $#ENSG00000127081#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000364645#ENSG00000127081#ENST00000375495#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2, zinc_ribbon_15$#ENSP00000364646#ENSG00000127081#ENST00000332591#C2H2 ZF Containing Proteins#zf-H2C2_2$#ENSP00000378881#ENSG00000127081#ENST00000395505#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2, zinc_ribbon_15$#ENSP00000378882#ENSG00000127081#ENST00000395506#C2H2 ZF Containing Proteins#zf-H2C2_2 TRUE 682 ENSG00000198298 ZNF485 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 220992 zinc finger protein 485 [Source:HGNC Symbol;Acc:HGNC:23440] None Full not tested None None b Yes No No 1a1, Direct HQ evidence Arttu Jolma Jussi Taipale Yes None $#ENSP00000354694#ENSG00000198298#ENST00000361807#C2H2 ZF Containing Proteins#KRAB$#ENSP00000363558#ENSG00000198298#ENST00000374435#C2H2 ZF Containing Proteins#KRAB$#ENSP00000393570#ENSG00000198298#ENST00000430885#C2H2 ZF Containing Proteins#KRAB TRUE 683 ENSG00000256229 ZNF486 C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect None IPR001909;IPR007087;IPR015880; 90649 zinc finger protein 486 [Source:HGNC Symbol;Acc:HGNC:20807] None DBD and Full not tested None None b Yes No No 2a2, orthologous lower confidence evidence Sam Lambert Arttu Jolma No None $#ENSP00000335042#ENSG00000256229#ENST00000335117#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2$#ENSP00000469306#ENSG00000256229#ENST00000597083#C2H2 ZF Containing Proteins#KRAB TRUE 684 ENSG00000243660 ZNF487 C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source Single C2H2 domain; Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect None IPR001909; None zinc finger protein 487 [Source:HGNC Symbol;Acc:HGNC:23488] None not tested not tested None None No No No No 1a1, Direct HQ evidence Pratyush Das Arttu Jolma Yes None $#ENSP00000314093#ENSG00000243660#ENST00000315429#Other#KRAB$#ENSP00000392335#ENSG00000243660#ENST00000437590#Other#$#ENSP00000395135#ENSG00000243660#ENST00000451167#Other#$#ENSP00000395343#ENSG00000243660#ENST00000456416#Other# TRUE 685 ENSG00000265763 ZNF488 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Virtually nothing is known for this protein except that it has two znfC2H2 domains IPR007087;IPR015880 118738 zinc finger protein 488 [Source:HGNC Symbol;Acc:HGNC:23535] None DBD and Full not tested None None b Yes No No 4a, two or more datasets predict it as a TF Sam Lambert Arttu Jolma No None $#ENSP00000462269#ENSG00000265763#ENST00000585316#C2H2 ZF Containing Proteins#$#ENSP00000468133#ENSG00000265763#ENST00000591025#C2H2 ZF Containing Proteins# FALSE 686 ENSG00000188033 ZNF490 C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect None IPR001909;IPR007087;IPR015880; 57474 zinc finger protein 490 [Source:HGNC Symbol;Acc:HGNC:23705] None DBD and Full not tested None None b Yes No Yes 1a1, Direct HQ evidence Yimeng Yin Arttu Jolma Yes $#ENSG00000188033#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000311521#ENSG00000188033#ENST00000311437#C2H2 ZF Containing Proteins#KRAB$#ENSP00000404112#ENSG00000188033#ENST00000440366#C2H2 ZF Containing Proteins#KRAB TRUE 687 ENSG00000177599 ZNF491 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains IPR007087;IPR015880 126069 zinc finger protein 491 [Source:HGNC Symbol;Acc:HGNC:23706] None DBD and Full not tested None None b Yes No No 4a, two or more datasets predict it as a TF Arttu Jolma Laura Campitelli Yes None $#ENSP00000313443#ENSG00000177599#ENST00000323169#C2H2 ZF Containing Proteins#$#ENSP00000392176#ENSG00000177599#ENST00000450087#C2H2 ZF Containing Proteins#zf-H2C2_2 FALSE 688 ENSG00000229676 ZNF492 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 57615 zinc finger protein 492 [Source:HGNC Symbol;Acc:HGNC:23707] None not tested not tested None TFs that are in CisBP but not in Vaquerizas set No Yes No No 1a1, Direct HQ evidence Pratyush Das Jussi Taipale Yes None $#ENSP00000413660#ENSG00000229676#ENST00000456783#C2H2 ZF Containing Proteins# TRUE 689 ENSG00000196268 ZNF493 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR001909;IPR007087;IPR015880; 284443 zinc finger protein 493 [Source:HGNC Symbol;Acc:HGNC:23708] None not tested not tested None None b Yes No Yes 4a, two or more datasets predict it as a TF Laura Campitelli Yimeng Yin Yes $#ENSG00000196268#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000340651#ENSG00000196268#ENST00000339914#C2H2 ZF Containing Proteins#KRAB$#ENSP00000347691#ENSG00000196268#ENST00000355504#C2H2 ZF Containing Proteins#$#ENSP00000376110#ENSG00000196268#ENST00000392288#C2H2 ZF Containing Proteins#KRAB$#ENSP00000469368#ENSG00000196268#ENST00000596302#C2H2 ZF Containing Proteins#KRAB$#ENSP00000469680#ENSG00000196268#ENST00000594390#C2H2 ZF Containing Proteins#KRAB$#ENSP00000472110#ENSG00000196268#ENST00000599461#C2H2 ZF Containing Proteins# FALSE 690 ENSG00000162714 ZNF496 C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect None IPR001909;IPR003309;IPR007087;IPR008916;IPR015880; 84838 zinc finger protein 496 [Source:HGNC Symbol;Acc:HGNC:23713] None DBD and Full not tested None None b Yes TF Gene_Transcription Factor Binding: tf co-factor binding; DNA-Binding: sequence-specific_DNA Binding; TF PPI; Transactivation_PMIDS:15169884 Yes 1a1, Direct HQ evidence Pratyush Das Arttu Jolma Yes $#ENSG00000162714#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000294753#ENSG00000162714#ENST00000294753#C2H2 ZF Containing Proteins#KRAB, SCAN$#ENSP00000473324#ENSG00000162714#ENST00000461277#C2H2 ZF Containing Proteins#KRAB TRUE 691 ENSG00000174586 ZNF497 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR007087;IPR015880 162968 zinc finger protein 497 [Source:HGNC Symbol;Acc:HGNC:23714] None Full not tested None None b Yes No No 4a, two or more datasets predict it as a TF Laura Campitelli Yimeng Yin Yes None $#ENSP00000402815#ENSG00000174586#ENST00000425453#C2H2 ZF Containing Proteins#ADK_lid$#ENSP00000311183#ENSG00000174586#ENST00000311044#C2H2 ZF Containing Proteins#ADK_lid$#ENSP00000471650#ENSG00000174586#ENST00000595763#C2H2 ZF Containing Proteins# FALSE 692 ENSG00000103199 ZNF500 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR001909;IPR003309;IPR007087;IPR008916;IPR015880; 26048 zinc finger protein 500 [Source:HGNC Symbol;Acc:HGNC:23716] None Full not tested None None b Yes No Yes 4a, two or more datasets predict it as a TF Tim Hughes Jussi Taipale Yes $#ENSG00000103199#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000219478#ENSG00000103199#ENST00000219478#C2H2 ZF Containing Proteins#KRAB, SCAN$#ENSP00000445714#ENSG00000103199#ENST00000545009#C2H2 ZF Containing Proteins#KRAB, SCAN$#ENSP00000464747#ENSG00000103199#ENST00000592425#C2H2 ZF Containing Proteins#$#ENSP00000465073#ENSG00000103199#ENST00000588942#C2H2 ZF Containing Proteins# TRUE 693 ENSG00000186446 ZNF501 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR007087;IPR015880 115560 zinc finger protein 501 [Source:HGNC Symbol;Acc:HGNC:23717] None DBD and Full not tested None None b Yes No Yes 1a1, Direct HQ evidence Sam Lambert Pratyush Das Yes $#ENSG00000186446#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000379363#ENSG00000186446#ENST00000396048#C2H2 ZF Containing Proteins#$#ENSP00000482632#ENSG00000186446#ENST00000620116#C2H2 ZF Containing Proteins# FALSE 694 ENSG00000196653 ZNF502 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR007087;IPR015880 91392 zinc finger protein 502 [Source:HGNC Symbol;Acc:HGNC:23718] None DBD and Full not tested None None b Yes No No 1a1, Direct HQ evidence Jussi Taipale Arttu Jolma Yes None $#ENSP00000296091#ENSG00000196653#ENST00000296091#C2H2 ZF Containing Proteins#$#ENSP00000406469#ENSG00000196653#ENST00000436624#C2H2 ZF Containing Proteins#$#ENSP00000401717#ENSG00000196653#ENST00000411443#C2H2 ZF Containing Proteins#$#ENSP00000397390#ENSG00000196653#ENST00000449836#C2H2 ZF Containing Proteins# FALSE 695 ENSG00000165655 ZNF503 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif Single C2H2 domain None IPR007087;IPR022129 84858 zinc finger protein 503 [Source:HGNC Symbol;Acc:HGNC:23589] None DBD and Full not tested None None b Yes No No 4a, two or more datasets predict it as a TF Sam Lambert Laura Campitelli No None $#ENSP00000361602#ENSG00000165655#ENST00000372524#C2H2 ZF Containing Proteins#nlz1 FALSE 696 ENSG00000081665 ZNF506 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) Has a nice cassette of znfC2H2 domains and a KRAB domain IPR001909;IPR007087;IPR015880; 440515 zinc finger protein 506 [Source:HGNC Symbol;Acc:HGNC:23780] None DBD not tested None None b Yes No No 1a1, Direct HQ evidence Jussi Taipale Pratyush Das Yes $#ENSG00000081665#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:25274305 | NAS - PMID:2023909 $#ENSP00000445149#ENSG00000081665#ENST00000545006#C2H2 ZF Containing Proteins#KRAB$#ENSP00000393835#ENSG00000081665#ENST00000443905#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2$#ENSP00000440625#ENSG00000081665#ENST00000540806#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2$#ENSP00000468217#ENSG00000081665#ENST00000587461#C2H2 ZF Containing Proteins#KRAB TRUE 697 ENSG00000168813 ZNF507 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR007087;IPR015880 22847 zinc finger protein 507 [Source:HGNC Symbol;Acc:HGNC:23783] None DBD not tested None None b Yes No No 4a, two or more datasets predict it as a TF Sam Lambert Pratyush Das Yes None $#ENSP00000312277#ENSG00000168813#ENST00000311921#C2H2 ZF Containing Proteins#$#ENSP00000348162#ENSG00000168813#ENST00000355898#C2H2 ZF Containing Proteins#$#ENSP00000441549#ENSG00000168813#ENST00000544431#C2H2 ZF Containing Proteins# FALSE 698 ENSG00000081386 ZNF510 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Virtually nothing is known for this protein except that it has decent cassettes of znfC2H2 domains IPR001909;IPR007087;IPR015880; 22869 zinc finger protein 510 [Source:HGNC Symbol;Acc:HGNC:29161] None DBD not tested None None b Yes No No 4a, two or more datasets predict it as a TF Yimeng Yin Arttu Jolma Yes None $#ENSP00000223428#ENSG00000081386#ENST00000223428#C2H2 ZF Containing Proteins#KRAB$#ENSP00000364379#ENSG00000081386#ENST00000375231#C2H2 ZF Containing Proteins#KRAB$#ENSP00000363772#ENSG00000081386#ENST00000374641#C2H2 ZF Containing Proteins#KRAB TRUE 699 ENSG00000198546 ZNF511 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR007087;IPR015880 118472 zinc finger protein 511 [Source:HGNC Symbol;Acc:HGNC:28445] None DBD and Full not tested None None b Yes No No 4a, two or more datasets predict it as a TF Jussi Taipale Laura Campitelli Yes None $#ENSP00000355251#ENSG00000198546#ENST00000361518#C2H2 ZF Containing Proteins#zf-C2H2_4, zf-C2H2_aberr$#ENSP00000351929#ENSG00000198546#ENST00000359035#C2H2 ZF Containing Proteins#zf-C2H2_aberr FALSE 700 ENSG00000196700 ZNF512B C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif Has a putative AT-hook Protein has znfC2H2 domains but they are fragmented rather than making decent cassettes IPR007087;IPR015880 57473 zinc finger protein 512B [Source:HGNC Symbol;Acc:HGNC:29212] None Full not tested None None x Yes No No 4a, two or more datasets predict it as a TF Pratyush Das Arttu Jolma Yes None $#ENSP00000358904#ENSG00000196700#ENST00000369888#C2H2 ZF Containing Proteins#zf-C2H2_4, zf-met FALSE 701 ENSG00000163795 ZNF513 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR007087;IPR015880 130557 zinc finger protein 513 [Source:HGNC Symbol;Acc:HGNC:26498] None DBD and Full not tested None None b Yes No No 1a1, Direct HQ evidence Pratyush Das Laura Campitelli Yes None $#ENSP00000318373#ENSG00000163795#ENST00000323703#C2H2 ZF Containing Proteins#$#ENSP00000384874#ENSG00000163795#ENST00000407879#C2H2 ZF Containing Proteins#$#ENSP00000394226#ENSG00000163795#ENST00000436006#C2H2 ZF Containing Proteins#zf-H2C2_5 FALSE 702 ENSG00000144026 ZNF514 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR001909;IPR007087;IPR015880; 84874 zinc finger protein 514 [Source:HGNC Symbol;Acc:HGNC:25894] None DBD and Full not tested None None b Yes No Yes 4a, two or more datasets predict it as a TF Sam Lambert Laura Campitelli Yes $#ENSG00000144026#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000295208#ENSG00000144026#ENST00000295208#C2H2 ZF Containing Proteins#KRAB$#ENSP00000405509#ENSG00000144026#ENST00000411425#C2H2 ZF Containing Proteins#KRAB$#ENSP00000399647#ENSG00000144026#ENST00000447814#C2H2 ZF Containing Proteins#KRAB TRUE 703 ENSG00000101493 ZNF516 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR007087;IPR015880 9658 zinc finger protein 516 [Source:HGNC Symbol;Acc:HGNC:28990] None not tested not tested None None b Yes No Yes 4a, two or more datasets predict it as a TF Yimeng Yin Jussi Taipale Yes $#ENSG00000101493#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000394757#ENSG00000101493#ENST00000443185#C2H2 ZF Containing Proteins#$#ENSP00000478712#ENSG00000101493#ENST00000617840#C2H2 ZF Containing Proteins#$#ENSP00000446211#ENSG00000101493#ENST00000532857#C2H2 ZF Containing Proteins#$#ENSP00000445902#ENSG00000101493#ENST00000542818#C2H2 ZF Containing Proteins# FALSE 704 ENSG00000197363 ZNF517 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR001909;IPR007087;IPR015880; 340385 zinc finger protein 517 [Source:HGNC Symbol;Acc:HGNC:27984] None Full not tested None None b Yes No No 4a, two or more datasets predict it as a TF Sam Lambert Yimeng Yin Yes None $#ENSP00000433299#ENSG00000197363#ENST00000525105#C2H2 ZF Containing Proteins#KRAB$#ENSP00000432025#ENSG00000197363#ENST00000529429#C2H2 ZF Containing Proteins#$#ENSP00000436103#ENSG00000197363#ENST00000531720#C2H2 ZF Containing Proteins#KRAB$#ENSP00000353058#ENSG00000197363#ENST00000359971#C2H2 ZF Containing Proteins#KRAB TRUE 705 ENSG00000177853 ZNF518A C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains and that it interacts with polycomb repressor complex 2 PMID: 25680957 IPR007087;IPR015880 9849 zinc finger protein 518A [Source:HGNC Symbol;Acc:HGNC:29009] None Full not tested None None b Yes No Yes 4a, two or more datasets predict it as a TF Jussi Taipale Arttu Jolma Yes $#ENSG00000177853#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000479684#ENSG00000177853#ENST00000316045#C2H2 ZF Containing Proteins#zf-H2C2_2, zf-H2C2_5$#ENSP00000480280#ENSG00000177853#ENST00000478086#C2H2 ZF Containing Proteins#zf-C2H2_4$#ENSP00000485614#ENSG00000177853#ENST00000624776#C2H2 ZF Containing Proteins#zf-H2C2_2, zf-H2C2_5$#ENSP00000481657#ENSG00000177853#ENST00000614149#C2H2 ZF Containing Proteins#zf-H2C2_2, zf-H2C2_5 FALSE 706 ENSG00000178163 ZNF518B C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR007087;IPR015880 85460 zinc finger protein 518B [Source:HGNC Symbol;Acc:HGNC:29365] None not tested not tested None None c Yes No Yes 4a, two or more datasets predict it as a TF Jussi Taipale Yimeng Yin Yes $#ENSG00000178163#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000317614#ENSG00000178163#ENST00000326756#C2H2 ZF Containing Proteins#$#ENSP00000425298#ENSG00000178163#ENST00000507515#C2H2 ZF Containing Proteins# FALSE 707 ENSG00000175322 ZNF519 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 162655 zinc finger protein 519 [Source:HGNC Symbol;Acc:HGNC:30574] None DBD and Full not tested None None b Yes No No 1a1, Direct HQ evidence Pratyush Das Jussi Taipale Yes None $#ENSP00000464872#ENSG00000175322#ENST00000590202#C2H2 ZF Containing Proteins#KRAB$#ENSP00000465159#ENSG00000175322#ENST00000589498#C2H2 ZF Containing Proteins#KRAB TRUE 708 ENSG00000198795 ZNF521 C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain None IPR007087;IPR015880 25925 zinc finger protein 521 [Source:HGNC Symbol;Acc:HGNC:24605] None Full not tested None None b Yes Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0 No 2a1, Lower confidence direct evidence Pratyush Das Arttu Jolma Yes None $#ENSP00000354794#ENSG00000198795#ENST00000361524#C2H2 ZF Containing Proteins#zf-C2H2_2, zf-C2H2_4, zf-C2H2_6, zf-C2H2_jaz, zf-D$#ENSP00000463000#ENSG00000198795#ENST00000584787#C2H2 ZF Containing Proteins#zf-C2H2_2, zf-C2H2_4, zf-C2H2_6, zf-C2H2_jaz, zf-D$#ENSP00000440768#ENSG00000198795#ENST00000538137#C2H2 ZF Containing Proteins#zf-C2H2_2, zf-C2H2_4, zf-C2H2_6, zf-C2H2_jaz, zf-D$#ENSP00000462746#ENSG00000198795#ENST00000577461#C2H2 ZF Containing Proteins#$#ENSP00000463748#ENSG00000198795#ENST00000577775#C2H2 ZF Containing Proteins# FALSE 709 ENSG00000203326 ZNF525 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; None zinc finger protein 525 [Source:HGNC Symbol;Acc:HGNC:29423] None not tested not tested None TFs that are in CisBP but not in Vaquerizas set No Yes No No 1a1, Direct HQ evidence Arttu Jolma Pratyush Das Yes None $#ENSP00000418468#ENSG00000203326#ENST00000475179#C2H2 ZF Containing Proteins#KRAB$#ENSP00000419136#ENSG00000203326#ENST00000467003#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2$#ENSP00000420476#ENSG00000203326#ENST00000491101#C2H2 ZF Containing Proteins#KRAB FALSE 710 ENSG00000167625 ZNF526 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains IPR007087;IPR015880 116115 zinc finger protein 526 [Source:HGNC Symbol;Acc:HGNC:29415] None Full not tested None None b Yes No No 4a, two or more datasets predict it as a TF Yimeng Yin Arttu Jolma Yes None $#ENSP00000301215#ENSG00000167625#ENST00000301215#C2H2 ZF Containing Proteins#zf-C2H2_4$#ENSP00000473075#ENSG00000167625#ENST00000597945#C2H2 ZF Containing Proteins# FALSE 711 ENSG00000189164 ZNF527 C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect None IPR001909;IPR007087;IPR015880; 84503 zinc finger protein 527 [Source:HGNC Symbol;Acc:HGNC:29385] None not tested not tested None None b Yes No No 1a1, Direct HQ evidence Arttu Jolma Jussi Taipale Yes None $#ENSP00000468344#ENSG00000189164#ENST00000483919#C2H2 ZF Containing Proteins#KRAB$#ENSP00000466096#ENSG00000189164#ENST00000587349#C2H2 ZF Containing Proteins#KRAB$#ENSP00000390179#ENSG00000189164#ENST00000436120#C2H2 ZF Containing Proteins#KRAB$#ENSP00000468517#ENSG00000189164#ENST00000588911#C2H2 ZF Containing Proteins#KRAB TRUE 712 ENSG00000167555 ZNF528 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 84436 zinc finger protein 528 [Source:HGNC Symbol;Acc:HGNC:29384] None not tested not tested None None x Yes No Yes 1a1, Direct HQ evidence Sam Lambert Jussi Taipale Yes $#ENSG00000167555#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000353652#ENSG00000167555#ENST00000360465#C2H2 ZF Containing Proteins#KRAB$#ENSP00000375665#ENSG00000167555#ENST00000391788#C2H2 ZF Containing Proteins#KRAB$#ENSP00000413711#ENSG00000167555#ENST00000436397#C2H2 ZF Containing Proteins#$#ENSP00000432992#ENSG00000167555#ENST00000493272#C2H2 ZF Containing Proteins#$#ENSP00000469481#ENSG00000167555#ENST00000594530#C2H2 ZF Containing Proteins#KRAB$#ENSP00000470536#ENSG00000167555#ENST00000598192#C2H2 ZF Containing Proteins#KRAB TRUE 713 ENSG00000186020 ZNF529 C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect None IPR001909;IPR007087;IPR015880; 57711 zinc finger protein 529 [Source:HGNC Symbol;Acc:HGNC:29328] None DBD and Full not tested None None b Yes No No 1a1, Direct HQ evidence Jussi Taipale Sam Lambert Yes None $#ENSP00000465578#ENSG00000186020#ENST00000591340#C2H2 ZF Containing Proteins#C1_4, KRAB, Zn-ribbon_8, zf-C2H2_6, zf-H2C2_2$#ENSP00000334695#ENSG00000186020#ENST00000334116#C2H2 ZF Containing Proteins#C1_4, Zn-ribbon_8, zf-C2H2_6, zf-H2C2_2$#ENSP00000465917#ENSG00000186020#ENST00000452073#C2H2 ZF Containing Proteins#$#ENSP00000468619#ENSG00000186020#ENST00000585983#C2H2 ZF Containing Proteins#KRAB$#ENSP00000468594#ENSG00000186020#ENST00000590656#C2H2 ZF Containing Proteins# TRUE 714 ENSG00000183647 ZNF530 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 348327 zinc finger protein 530 [Source:HGNC Symbol;Acc:HGNC:29297] None Full not tested None None b Yes No No 1a1, Direct HQ evidence Pratyush Das Arttu Jolma Yes None $#ENSP00000332861#ENSG00000183647#ENST00000332854#C2H2 ZF Containing Proteins#KRAB$#ENSP00000472024#ENSG00000183647#ENST00000597700#C2H2 ZF Containing Proteins#KRAB$#ENSP00000471527#ENSG00000183647#ENST00000597864#C2H2 ZF Containing Proteins#KRAB TRUE 715 ENSG00000074657 ZNF532 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Virtually nothing is known for this protein except that it has decent cassettes of znfC2H2 domains IPR007087;IPR015880 55205 zinc finger protein 532 [Source:HGNC Symbol;Acc:HGNC:30940] None Full not tested None None b Yes No Yes 4a, two or more datasets predict it as a TF Arttu Jolma Yimeng Yin Yes $#ENSG00000074657#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000338217#ENSG00000074657#ENST00000336078#C2H2 ZF Containing Proteins#$#ENSP00000466007#ENSG00000074657#ENST00000589288#C2H2 ZF Containing Proteins#$#ENSP00000468532#ENSG00000074657#ENST00000591083#C2H2 ZF Containing Proteins#$#ENSP00000465709#ENSG00000074657#ENST00000591230#C2H2 ZF Containing Proteins#$#ENSP00000468238#ENSG00000074657#ENST00000591808#C2H2 ZF Containing Proteins#$#ENSP00000464894#ENSG00000074657#ENST00000586997#C2H2 ZF Containing Proteins#$#ENSP00000465873#ENSG00000074657#ENST00000592452#C2H2 ZF Containing Proteins#$#ENSP00000468009#ENSG00000074657#ENST00000588456#C2H2 ZF Containing Proteins#$#ENSP00000465802#ENSG00000074657#ENST00000590285#C2H2 ZF Containing Proteins# FALSE 716 ENSG00000198633 ZNF534 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 147658 zinc finger protein 534 [Source:HGNC Symbol;Acc:HGNC:26337] None not tested not tested None None c Yes No Yes 1a1, Direct HQ evidence Sam Lambert Yimeng Yin Yes $#ENSG00000198633#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000327538#ENSG00000198633#ENST00000332323#C2H2 ZF Containing Proteins#KRAB$#ENSP00000391358#ENSG00000198633#ENST00000433050#C2H2 ZF Containing Proteins#KRAB$#ENSP00000301085#ENSG00000198633#ENST00000301085#C2H2 ZF Containing Proteins#KRAB$#ENSP00000409421#ENSG00000198633#ENST00000432303#C2H2 ZF Containing Proteins#KRAB$#ENSP00000480956#ENSG00000198633#ENST00000617900#C2H2 ZF Containing Proteins#KRAB TRUE 717 ENSG00000198597 ZNF536 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR007087;IPR015880 9745 zinc finger protein 536 [Source:HGNC Symbol;Acc:HGNC:29025] None DBD and Full not tested None None b Yes No Yes 4a, two or more datasets predict it as a TF Laura Campitelli Yimeng Yin Yes $#ENSG00000198597#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:19398580 $#ENSP00000347730#ENSG00000198597#ENST00000355537#C2H2 ZF Containing Proteins#zf-C2H2_assoc$#ENSP00000465268#ENSG00000198597#ENST00000591488#C2H2 ZF Containing Proteins#$#ENSP00000465771#ENSG00000198597#ENST00000585628#C2H2 ZF Containing Proteins#zf-C2H2_assoc$#ENSP00000467909#ENSG00000198597#ENST00000592773#C2H2 ZF Containing Proteins#zf-H2C2_5 FALSE 718 ENSG00000171817 ZNF540 C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect None IPR001909;IPR007087;IPR015880; 163255 zinc finger protein 540 [Source:HGNC Symbol;Acc:HGNC:25331] None Full not tested None None b Yes No Yes 1a1, Direct HQ evidence Pratyush Das Arttu Jolma Yes $#ENSG00000171817#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000324598#ENSG00000171817#ENST00000316433#C2H2 ZF Containing Proteins#KRAB$#ENSP00000467118#ENSG00000171817#ENST00000589117#C2H2 ZF Containing Proteins#KRAB$#ENSP00000466274#ENSG00000171817#ENST00000592533#C2H2 ZF Containing Proteins#KRAB$#ENSP00000468113#ENSG00000171817#ENST00000586792#C2H2 ZF Containing Proteins#$#ENSP00000467667#ENSG00000171817#ENST00000590588#C2H2 ZF Containing Proteins#KRAB TRUE 719 ENSG00000240225 ZNF542P C2H2 ZF No Unlikely to be sequence specific TF Not a DNA binding protein No motif Pseudogene None None 147947 Putative zinc finger protein 542 None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Sam Lambert Laura Campitelli Yes $#ENSG00000240225#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $##ENSG00000240225##Other# FALSE 720 ENSG00000178229 ZNF543 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 125919 zinc finger protein 543 [Source:HGNC Symbol;Acc:HGNC:25281] None Full not tested None None b Yes No No 1a1, Direct HQ evidence Jussi Taipale Sam Lambert Yes None $#ENSP00000322545#ENSG00000178229#ENST00000321545#C2H2 ZF Containing Proteins#KRAB TRUE 721 ENSG00000198131 ZNF544 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR001909;IPR007087;IPR015880; 27300 zinc finger protein 544 [Source:HGNC Symbol;Acc:HGNC:16759] None Full not tested None None b Yes No Yes 4a, two or more datasets predict it as a TF Sam Lambert Jussi Taipale Yes $#ENSG00000198131#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000269829#ENSG00000198131#ENST00000269829#C2H2 ZF Containing Proteins#KRAB, zf-C2H2_4, zf-C2H2_6, zf-H2C2_2$#ENSP00000472614#ENSG00000198131#ENST00000594384#C2H2 ZF Containing Proteins#KRAB$#ENSP00000469635#ENSG00000198131#ENST00000596652#C2H2 ZF Containing Proteins#KRAB, zf-C2H2_4, zf-C2H2_6, zf-H2C2_2$#ENSP00000472512#ENSG00000198131#ENST00000596825#C2H2 ZF Containing Proteins#KRAB$#ENSP00000471480#ENSG00000198131#ENST00000599227#C2H2 ZF Containing Proteins#KRAB$#ENSP00000485736#ENSG00000198131#ENST00000627781#C2H2 ZF Containing Proteins#KRAB$#ENSP00000470843#ENSG00000198131#ENST00000595981#C2H2 ZF Containing Proteins#KRAB$#ENSP00000471684#ENSG00000198131#ENST00000600220#C2H2 ZF Containing Proteins#KRAB, zf-C2H2_4, zf-C2H2_6, zf-H2C2_2 TRUE 722 ENSG00000187187 ZNF546 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains and a KRAB-domain IPR001909;IPR007087;IPR015880; 339327 zinc finger protein 546 [Source:HGNC Symbol;Acc:HGNC:28671] None Full not tested None None b Yes No Yes 4a, two or more datasets predict it as a TF Arttu Jolma Sam Lambert Yes $#ENSG00000187187#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000339823#ENSG00000187187#ENST00000347077#C2H2 ZF Containing Proteins#KRAB$#ENSP00000469540#ENSG00000187187#ENST00000600094#C2H2 ZF Containing Proteins#KRAB$#ENSP00000470423#ENSG00000187187#ENST00000596894#C2H2 ZF Containing Proteins# TRUE 723 ENSG00000152433 ZNF547 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 284306 zinc finger protein 547 [Source:HGNC Symbol;Acc:HGNC:26432] None Full not tested None None b Yes No No 1a1, Direct HQ evidence Arttu Jolma Pratyush Das Yes None $#ENSP00000282282#ENSG00000152433#ENST00000282282#C2H2 ZF Containing Proteins#KRAB$#ENSP00000470111#ENSG00000152433#ENST00000597567#C2H2 ZF Containing Proteins#KRAB$#ENSP00000468929#ENSG00000152433#ENST00000599604#C2H2 ZF Containing Proteins#KRAB TRUE 724 ENSG00000188785 ZNF548 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 147694 zinc finger protein 548 [Source:HGNC Symbol;Acc:HGNC:26561] None DBD and Full not tested None None b Yes No Yes 1a1, Direct HQ evidence Yimeng Yin Sam Lambert Yes $#ENSG00000188785#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000379482#ENSG00000188785#ENST00000366197#C2H2 ZF Containing Proteins#KRAB$#ENSP00000337555#ENSG00000188785#ENST00000336128#C2H2 ZF Containing Proteins#KRAB$#ENSP00000473179#ENSG00000188785#ENST00000597400#C2H2 ZF Containing Proteins#KRAB$#ENSP00000470982#ENSG00000188785#ENST00000600927#C2H2 ZF Containing Proteins#KRAB TRUE 725 ENSG00000121406 ZNF549 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 256051 zinc finger protein 549 [Source:HGNC Symbol;Acc:HGNC:26632] None DBD and Full not tested None None b Yes No Yes 1a1, Direct HQ evidence Arttu Jolma Laura Campitelli Yes $#ENSG00000121406#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000365407#ENSG00000121406#ENST00000376233#C2H2 ZF Containing Proteins#KRAB, zf-C2H2_4$#ENSP00000469280#ENSG00000121406#ENST00000602149#C2H2 ZF Containing Proteins#KRAB$#ENSP00000240719#ENSG00000121406#ENST00000240719#C2H2 ZF Containing Proteins#KRAB, zf-C2H2_4$#ENSP00000471315#ENSG00000121406#ENST00000594943#C2H2 ZF Containing Proteins# TRUE 726 ENSG00000251369 ZNF550 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 162972 zinc finger protein 550 [Source:HGNC Symbol;Acc:HGNC:28643] None not tested not tested None TFs that are in CisBP but not in Vaquerizas set No Yes No No 1a1, Direct HQ evidence Pratyush Das Arttu Jolma Yes None $#ENSP00000446224#ENSG00000251369#ENST00000325134#C2H2 ZF Containing Proteins#KRAB$#ENSP00000445978#ENSG00000251369#ENST00000344222#C2H2 ZF Containing Proteins#$#ENSP00000469679#ENSG00000251369#ENST00000457177#C2H2 ZF Containing Proteins#KRAB$#ENSP00000472973#ENSG00000251369#ENST00000601415#C2H2 ZF Containing Proteins#KRAB TRUE 727 ENSG00000204519 ZNF551 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR001909;IPR007087;IPR015880; 90233 zinc finger protein 551 [Source:HGNC Symbol;Acc:HGNC:25108] None Full not tested None None a Yes No Yes 4a, two or more datasets predict it as a TF Laura Campitelli Jussi Taipale Yes $#ENSG00000204519#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000282296#ENSG00000204519#ENST00000282296#C2H2 ZF Containing Proteins#KRAB$#ENSP00000472674#ENSG00000204519#ENST00000601064#C2H2 ZF Containing Proteins#KRAB$#ENSP00000472230#ENSG00000204519#ENST00000596085#C2H2 ZF Containing Proteins#KRAB TRUE 728 ENSG00000178935 ZNF552 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 79818 zinc finger protein 552 [Source:HGNC Symbol;Acc:HGNC:26135] None DBD and Full not tested None None b Yes No Yes 1a1, Direct HQ evidence Arttu Jolma Laura Campitelli Yes $#ENSG00000178935#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000375582#ENSG00000178935#ENST00000391701#C2H2 ZF Containing Proteins#KRAB, zf-C2H2_4, zf-H2C2_2$#ENSP00000472459#ENSG00000178935#ENST00000594473#C2H2 ZF Containing Proteins#KRAB TRUE 729 ENSG00000172006 ZNF554 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 115196 zinc finger protein 554 [Source:HGNC Symbol;Acc:HGNC:26629] None DBD and Full not tested None None b Yes No No 1a1, Direct HQ evidence Sam Lambert Jussi Taipale Yes None $#ENSP00000321132#ENSG00000172006#ENST00000317243#C2H2 ZF Containing Proteins#KRAB$#ENSP00000467997#ENSG00000172006#ENST00000591265#C2H2 ZF Containing Proteins#KRAB TRUE 730 ENSG00000186300 ZNF555 C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect None IPR001909;IPR007087;IPR015880; 148254 zinc finger protein 555 [Source:HGNC Symbol;Acc:HGNC:28382] None DBD and Full not tested None None b Yes No No 1a1, Direct HQ evidence Sam Lambert Yimeng Yin Yes None $#ENSP00000334853#ENSG00000186300#ENST00000334241#C2H2 ZF Containing Proteins#KRAB$#ENSP00000467893#ENSG00000186300#ENST00000591539#C2H2 ZF Containing Proteins#KRAB$#ENSP00000466982#ENSG00000186300#ENST00000585966#C2H2 ZF Containing Proteins# TRUE 731 ENSG00000172000 ZNF556 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains and a KRAB-domain IPR001909;IPR007087;IPR015880; 80032 zinc finger protein 556 [Source:HGNC Symbol;Acc:HGNC:25669] None DBD and Full not tested None None b Yes No No 4a, two or more datasets predict it as a TF Laura Campitelli Arttu Jolma Yes None $#ENSP00000467366#ENSG00000172000#ENST00000586426#C2H2 ZF Containing Proteins#KRAB$#ENSP00000302603#ENSG00000172000#ENST00000307635#C2H2 ZF Containing Proteins#KRAB TRUE 732 ENSG00000130544 ZNF557 C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect None IPR001909;IPR007087;IPR015880; 79230 zinc finger protein 557 [Source:HGNC Symbol;Acc:HGNC:28632] None Full not tested None None b Yes No No 1a1, Direct HQ evidence Laura Campitelli Pratyush Das Yes None $#ENSP00000252840#ENSG00000130544#ENST00000252840#C2H2 ZF Containing Proteins#KRAB$#ENSP00000404065#ENSG00000130544#ENST00000414706#C2H2 ZF Containing Proteins#KRAB TRUE 733 ENSG00000167785 ZNF558 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 148156 zinc finger protein 558 [Source:HGNC Symbol;Acc:HGNC:26422] None Full not tested None None b Yes No No 1a1, Direct HQ evidence Sam Lambert Yimeng Yin Yes None $#ENSP00000301475#ENSG00000167785#ENST00000301475#C2H2 ZF Containing Proteins#KRAB$#ENSP00000471277#ENSG00000167785#ENST00000601372#C2H2 ZF Containing Proteins#KRAB TRUE 734 ENSG00000188321 ZNF559 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR001909;IPR007087;IPR015880; 84527 zinc finger protein 559 [Source:HGNC Symbol;Acc:HGNC:28197] None DBD and Full not tested None None b Yes No No 4a, two or more datasets predict it as a TF Sam Lambert Yimeng Yin Yes None $#ENSP00000467048#ENSG00000188321#ENST00000585352#C2H2 ZF Containing Proteins#KRAB$#ENSP00000465787#ENSG00000188321#ENST00000586255#C2H2 ZF Containing Proteins#KRAB$#ENSP00000466496#ENSG00000188321#ENST00000592896#C2H2 ZF Containing Proteins#KRAB$#ENSP00000325393#ENSG00000188321#ENST00000317221#C2H2 ZF Containing Proteins#KRAB$#ENSP00000377461#ENSG00000188321#ENST00000393883#C2H2 ZF Containing Proteins#KRAB$#ENSP00000468153#ENSG00000188321#ENST00000587557#C2H2 ZF Containing Proteins#KRAB$#ENSP00000468299#ENSG00000188321#ENST00000592298#C2H2 ZF Containing Proteins#KRAB$#ENSP00000467841#ENSG00000188321#ENST00000592504#C2H2 ZF Containing Proteins#KRAB$#ENSP00000474760#ENSG00000188321#ENST00000603380#C2H2 ZF Containing Proteins#KRAB$#ENSP00000474719#ENSG00000188321#ENST00000605750#C2H2 ZF Containing Proteins#$#ENSP00000466745#ENSG00000188321#ENST00000591652#C2H2 ZF Containing Proteins#KRAB TRUE 735 ENSG00000198028 ZNF560 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR001909;IPR007087;IPR015880; 147741 zinc finger protein 560 [Source:HGNC Symbol;Acc:HGNC:26484] None DBD and Full not tested None None b Yes No No 4a, two or more datasets predict it as a TF Laura Campitelli Sam Lambert Yes None $#ENSP00000301480#ENSG00000198028#ENST00000301480#C2H2 ZF Containing Proteins#KRAB TRUE 736 ENSG00000171469 ZNF561 C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect None IPR001909;IPR007087;IPR015880; 93134 zinc finger protein 561 [Source:HGNC Symbol;Acc:HGNC:28684] None Full not tested None None b Yes No Yes 1a1, Direct HQ evidence Sam Lambert Pratyush Das Yes $#ENSG00000171469#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000303915#ENSG00000171469#ENST00000302851#C2H2 ZF Containing Proteins#KRAB$#ENSP00000370284#ENSG00000171469#ENST00000326044#C2H2 ZF Containing Proteins#KRAB$#ENSP00000393074#ENSG00000171469#ENST00000424629#C2H2 ZF Containing Proteins#$#ENSP00000392013#ENSG00000171469#ENST00000444611#C2H2 ZF Containing Proteins#KRAB TRUE 737 ENSG00000171466 ZNF562 C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect None IPR001909;IPR007087;IPR015880; 54811 zinc finger protein 562 [Source:HGNC Symbol;Acc:HGNC:25950] None DBD and Full not tested None None b Yes No No 1a1, Direct HQ evidence Arttu Jolma Laura Campitelli Yes None $#ENSP00000293648#ENSG00000171466#ENST00000293648#C2H2 ZF Containing Proteins#$#ENSP00000468039#ENSG00000171466#ENST00000587392#C2H2 ZF Containing Proteins#KRAB$#ENSP00000466911#ENSG00000171466#ENST00000588653#C2H2 ZF Containing Proteins#KRAB$#ENSP00000464716#ENSG00000171466#ENST00000590155#C2H2 ZF Containing Proteins#KRAB$#ENSP00000410734#ENSG00000171466#ENST00000453372#C2H2 ZF Containing Proteins#KRAB$#ENSP00000466039#ENSG00000171466#ENST00000589542#C2H2 ZF Containing Proteins#KRAB TRUE 738 ENSG00000188868 ZNF563 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 147837 zinc finger protein 563 [Source:HGNC Symbol;Acc:HGNC:30498] None Full not tested None None b Yes No No 1a1, Direct HQ evidence Sam Lambert Pratyush Das Yes None $#ENSP00000293725#ENSG00000188868#ENST00000293725#C2H2 ZF Containing Proteins#KRAB$#ENSP00000471960#ENSG00000188868#ENST00000594577#C2H2 ZF Containing Proteins#$#ENSP00000469879#ENSG00000188868#ENST00000595977#C2H2 ZF Containing Proteins#KRAB, zf-C2H2_2$#ENSP00000472052#ENSG00000188868#ENST00000601858#C2H2 ZF Containing Proteins# TRUE 739 ENSG00000249709 ZNF564 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 163050 zinc finger protein 564 [Source:HGNC Symbol;Acc:HGNC:31106] None not tested not tested None TFs that are in CisBP but not in Vaquerizas set No Yes No Yes 1a1, Direct HQ evidence Pratyush Das Yimeng Yin Yes $#ENSG00000249709#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000340004#ENSG00000249709#ENST00000339282#C2H2 ZF Containing Proteins#KRAB$#ENSP00000408822#ENSG00000249709#ENST00000416136#C2H2 ZF Containing Proteins#$#ENSP00000470670#ENSG00000249709#ENST00000596193#C2H2 ZF Containing Proteins# TRUE 740 ENSG00000196357 ZNF565 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 147929 zinc finger protein 565 [Source:HGNC Symbol;Acc:HGNC:26726] None DBD not tested None None b Yes No Yes 1a1, Direct HQ evidence Sam Lambert Pratyush Das Yes $#ENSG00000196357#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000465906#ENSG00000196357#ENST00000591473#C2H2 ZF Containing Proteins#$#ENSP00000306869#ENSG00000196357#ENST00000304116#C2H2 ZF Containing Proteins#KRAB$#ENSP00000347234#ENSG00000196357#ENST00000355114#C2H2 ZF Containing Proteins#KRAB$#ENSP00000376013#ENSG00000196357#ENST00000392173#C2H2 ZF Containing Proteins#KRAB TRUE 741 ENSG00000186017 ZNF566 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 84924 zinc finger protein 566 [Source:HGNC Symbol;Acc:HGNC:25919] None DBD and Full not tested None None b Yes No No 1a1, Direct HQ evidence Sam Lambert Arttu Jolma Yes None $#ENSP00000465343#ENSG00000186017#ENST00000493391#C2H2 ZF Containing Proteins#$#ENSP00000401259#ENSG00000186017#ENST00000424129#C2H2 ZF Containing Proteins#KRAB$#ENSP00000400651#ENSG00000186017#ENST00000427002#C2H2 ZF Containing Proteins#KRAB$#ENSP00000415520#ENSG00000186017#ENST00000434377#C2H2 ZF Containing Proteins#KRAB$#ENSP00000411526#ENSG00000186017#ENST00000452939#C2H2 ZF Containing Proteins#KRAB$#ENSP00000467764#ENSG00000186017#ENST00000587567#C2H2 ZF Containing Proteins# TRUE 742 ENSG00000189042 ZNF567 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 163081 zinc finger protein 567 [Source:HGNC Symbol;Acc:HGNC:28696] None Full not tested None None b Yes No Yes 1a1, Direct HQ evidence Arttu Jolma Yimeng Yin Yes $#ENSG00000189042#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000353957#ENSG00000189042#ENST00000360729#C2H2 ZF Containing Proteins#KRAB$#ENSP00000467379#ENSG00000189042#ENST00000585696#C2H2 ZF Containing Proteins#KRAB$#ENSP00000441838#ENSG00000189042#ENST00000536254#C2H2 ZF Containing Proteins#KRAB$#ENSP00000467712#ENSG00000189042#ENST00000588311#C2H2 ZF Containing Proteins#KRAB$#ENSP00000466458#ENSG00000189042#ENST00000589264#C2H2 ZF Containing Proteins#KRAB TRUE 743 ENSG00000198453 ZNF568 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR001909;IPR007087;IPR015880; 374900 zinc finger protein 568 [Source:HGNC Symbol;Acc:HGNC:25392] None DBD and Full not tested None None b Yes No Yes 4a, two or more datasets predict it as a TF Laura Campitelli Yimeng Yin Yes $#ENSG00000198453#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000334685#ENSG00000198453#ENST00000333987#C2H2 ZF Containing Proteins#KRAB$#ENSP00000394514#ENSG00000198453#ENST00000415168#C2H2 ZF Containing Proteins#KRAB$#ENSP00000407012#ENSG00000198453#ENST00000427117#C2H2 ZF Containing Proteins#KRAB$#ENSP00000389794#ENSG00000198453#ENST00000444991#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2$#ENSP00000465833#ENSG00000198453#ENST00000586353#C2H2 ZF Containing Proteins#Toxin_16$#ENSP00000481819#ENSG00000198453#ENST00000619231#C2H2 ZF Containing Proteins#KRAB$#ENSP00000413396#ENSG00000198453#ENST00000455427#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2$#ENSP00000407153#ENSG00000198453#ENST00000455817#C2H2 ZF Containing Proteins#$#ENSP00000466901#ENSG00000198453#ENST00000587857#C2H2 ZF Containing Proteins#KRAB TRUE 744 ENSG00000196437 ZNF569 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR001909;IPR007087;IPR015880; 148266 zinc finger protein 569 [Source:HGNC Symbol;Acc:HGNC:24737] None DBD and Full not tested None None b Yes No No 4a, two or more datasets predict it as a TF Pratyush Das Jussi Taipale Yes None $#ENSP00000325018#ENSG00000196437#ENST00000316950#C2H2 ZF Containing Proteins#KRAB$#ENSP00000375992#ENSG00000196437#ENST00000392149#C2H2 ZF Containing Proteins#KRAB$#ENSP00000375993#ENSG00000196437#ENST00000392150#C2H2 ZF Containing Proteins#$#ENSP00000466221#ENSG00000196437#ENST00000448051#C2H2 ZF Containing Proteins#KRAB$#ENSP00000467046#ENSG00000196437#ENST00000589833#C2H2 ZF Containing Proteins#KRAB$#ENSP00000465577#ENSG00000196437#ENST00000592490#C2H2 ZF Containing Proteins# TRUE 745 ENSG00000171970 ZNF57 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Has a nice cassette of znfC2H2 domains and has been shown to be expressed in many tissues and to be able to repress transcription (PMID: 20356463). IPR001909;IPR007087;IPR015880; 126295 zinc finger protein 57 [Source:HGNC Symbol;Acc:HGNC:13125] None Full not tested None None b Yes No No 4a, two or more datasets predict it as a TF Arttu Jolma Yimeng Yin Yes None $#ENSP00000303696#ENSG00000171970#ENST00000306908#C2H2 ZF Containing Proteins#KRAB$#ENSP00000430223#ENSG00000171970#ENST00000523428#C2H2 ZF Containing Proteins#$#ENSP00000468191#ENSG00000171970#ENST00000590305#C2H2 ZF Containing Proteins# TRUE 746 ENSG00000171827 ZNF570 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 148268 zinc finger protein 570 [Source:HGNC Symbol;Acc:HGNC:26416] None Full not tested None None b Yes No Yes 1a1, Direct HQ evidence Yimeng Yin Arttu Jolma Yes $#ENSG00000171827#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000331540#ENSG00000171827#ENST00000330173#C2H2 ZF Containing Proteins#KRAB$#ENSP00000467218#ENSG00000171827#ENST00000586475#C2H2 ZF Containing Proteins#KRAB$#ENSP00000467246#ENSG00000171827#ENST00000589725#C2H2 ZF Containing Proteins#KRAB TRUE 747 ENSG00000180479 ZNF571 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR008981;IPR015880 51276 zinc finger protein 571 [Source:HGNC Symbol;Acc:HGNC:25000] None Full not tested None None b Yes No Yes 1a1, Direct HQ evidence Pratyush Das Yimeng Yin Yes $#ENSG00000180479#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000333660#ENSG00000180479#ENST00000328550#C2H2 ZF Containing Proteins#KRAB$#ENSP00000392638#ENSG00000180479#ENST00000451802#C2H2 ZF Containing Proteins#KRAB$#ENSP00000467572#ENSG00000180479#ENST00000593133#C2H2 ZF Containing Proteins#KRAB$#ENSP00000351594#ENSG00000180479#ENST00000358744#C2H2 ZF Containing Proteins#KRAB$#ENSP00000466225#ENSG00000180479#ENST00000590390#C2H2 ZF Containing Proteins#KRAB$#ENSP00000468192#ENSG00000180479#ENST00000590751#C2H2 ZF Containing Proteins#KRAB TRUE 748 ENSG00000180938 ZNF572 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains IPR007087;IPR015880 137209 zinc finger protein 572 [Source:HGNC Symbol;Acc:HGNC:26758] None DBD and Full not tested None None b Yes No No 4a, two or more datasets predict it as a TF Arttu Jolma Yimeng Yin Yes None $#ENSP00000319305#ENSG00000180938#ENST00000319286#C2H2 ZF Containing Proteins# FALSE 749 ENSG00000189144 ZNF573 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 126231 zinc finger protein 573 [Source:HGNC Symbol;Acc:HGNC:26420] None not tested not tested None None b Yes No Yes 1a1, Direct HQ evidence Jussi Taipale Laura Campitelli Yes $#ENSG00000189144#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000465020#ENSG00000189144#ENST00000590414#C2H2 ZF Containing Proteins#KRAB$#ENSP00000375983#ENSG00000189144#ENST00000392138#C2H2 ZF Containing Proteins#$#ENSP00000367706#ENSG00000189144#ENST00000378445#C2H2 ZF Containing Proteins#KRAB$#ENSP00000440464#ENSG00000189144#ENST00000536220#C2H2 ZF Containing Proteins#KRAB$#ENSP00000468391#ENSG00000189144#ENST00000588218#C2H2 ZF Containing Proteins#KRAB TRUE 750 ENSG00000105732 ZNF574 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR007087;IPR015880 64763 zinc finger protein 574 [Source:HGNC Symbol;Acc:HGNC:26166] None Full not tested None None b Yes No No 1a1, Direct HQ evidence Jussi Taipale Yimeng Yin Yes None $#ENSP00000351939#ENSG00000105732#ENST00000359044#C2H2 ZF Containing Proteins#zf-C2H2_4, zf-C2H2_6$#ENSP00000469029#ENSG00000105732#ENST00000600245#C2H2 ZF Containing Proteins#zf-C2H2_4, zf-C2H2_6$#ENSP00000222339#ENSG00000105732#ENST00000222339#C2H2 ZF Containing Proteins#zf-C2H2_4, zf-C2H2_6$#ENSP00000471611#ENSG00000105732#ENST00000597391#C2H2 ZF Containing Proteins# FALSE 751 ENSG00000176472 ZNF575 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR007087;IPR015880 284346 zinc finger protein 575 [Source:HGNC Symbol;Acc:HGNC:27606] None Full not tested None None b Yes No No 4a, two or more datasets predict it as a TF Yimeng Yin Pratyush Das Yes None $#ENSP00000315870#ENSG00000176472#ENST00000314228#C2H2 ZF Containing Proteins#$#ENSP00000413956#ENSG00000176472#ENST00000458714#C2H2 ZF Containing Proteins#$#ENSP00000472578#ENSG00000176472#ENST00000601282#C2H2 ZF Containing Proteins#$#ENSP00000471083#ENSG00000176472#ENST00000598080#C2H2 ZF Containing Proteins# FALSE 752 ENSG00000124444 ZNF576 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR007087;IPR015880 79177 zinc finger protein 576 [Source:HGNC Symbol;Acc:HGNC:28357] None DBD and Full not tested None None b Yes No No 4a, two or more datasets predict it as a TF Yimeng Yin Tim Hughes Yes None $#ENSP00000337852#ENSG00000124444#ENST00000336564#C2H2 ZF Containing Proteins#$#ENSP00000375827#ENSG00000124444#ENST00000391965#C2H2 ZF Containing Proteins#$#ENSP00000436182#ENSG00000124444#ENST00000525771#C2H2 ZF Containing Proteins#$#ENSP00000435463#ENSG00000124444#ENST00000529930#C2H2 ZF Containing Proteins#$#ENSP00000435899#ENSG00000124444#ENST00000533118#C2H2 ZF Containing Proteins#$#ENSP00000435934#ENSG00000124444#ENST00000528387#C2H2 ZF Containing Proteins# FALSE 753 ENSG00000161551 ZNF577 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR001909;IPR007087;IPR015880; 84765 zinc finger protein 577 [Source:HGNC Symbol;Acc:HGNC:28673] None Full not tested None None b Yes No Yes 4a, two or more datasets predict it as a TF Jussi Taipale Yimeng Yin Yes $#ENSG00000161551#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000301399#ENSG00000161551#ENST00000301399#C2H2 ZF Containing Proteins#KRAB TRUE 754 ENSG00000258405 ZNF578 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains and a KRAB-domain IPR001909;IPR007087;IPR015880; 147660 zinc finger protein 578 [Source:HGNC Symbol;Acc:HGNC:26449] None Full not tested None None x Yes No No 4a, two or more datasets predict it as a TF Laura Campitelli Arttu Jolma Yes None $#ENSP00000459216#ENSG00000258405#ENST00000421239#C2H2 ZF Containing Proteins#KRAB, Zn-ribbon_8$#ENSP00000470790#ENSG00000258405#ENST00000601120#C2H2 ZF Containing Proteins#KRAB TRUE 755 ENSG00000218891 ZNF579 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR007087;IPR015880 163033 zinc finger protein 579 [Source:HGNC Symbol;Acc:HGNC:26646] None not tested not tested None None b Yes No No 4a, two or more datasets predict it as a TF Jussi Taipale Arttu Jolma Yes None $#ENSP00000320188#ENSG00000218891#ENST00000325421#C2H2 ZF Containing Proteins#$#ENSP00000465146#ENSG00000218891#ENST00000592239#C2H2 ZF Containing Proteins# FALSE 756 ENSG00000213015 ZNF580 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR007087;IPR015880 51157 zinc finger protein 580 [Source:HGNC Symbol;Acc:HGNC:29473] None DBD not tested None None b Yes No No 1a1, Direct HQ evidence Arttu Jolma Sam Lambert Yes None $#ENSP00000320050#ENSG00000213015#ENST00000325333#C2H2 ZF Containing Proteins#$#ENSP00000446126#ENSG00000213015#ENST00000545125#C2H2 ZF Containing Proteins#$#ENSP00000465028#ENSG00000213015#ENST00000590190#C2H2 ZF Containing Proteins#$#ENSP00000467142#ENSG00000213015#ENST00000592461#C2H2 ZF Containing Proteins#$#ENSP00000468407#ENSG00000213015#ENST00000592881#C2H2 ZF Containing Proteins#$#ENSP00000443957#ENSG00000213015#ENST00000543039#C2H2 ZF Containing Proteins# FALSE 757 ENSG00000171425 ZNF581 C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain None IPR007087;IPR015880 51545 zinc finger protein 581 [Source:HGNC Symbol;Acc:HGNC:25017] None DBD and Full not tested None None b Yes No No 2a1, Lower confidence direct evidence Sam Lambert Arttu Jolma Yes None $#ENSP00000270451#ENSG00000171425#ENST00000270451#C2H2 ZF Containing Proteins#$#ENSP00000466047#ENSG00000171425#ENST00000587252#C2H2 ZF Containing Proteins#$#ENSP00000466338#ENSG00000171425#ENST00000585995#C2H2 ZF Containing Proteins#$#ENSP00000466564#ENSG00000171425#ENST00000588537#C2H2 ZF Containing Proteins# FALSE 758 ENSG00000018869 ZNF582 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 147948 zinc finger protein 582 [Source:HGNC Symbol;Acc:HGNC:26421] None Full not tested None None b Yes No No 1a1, Direct HQ evidence Tim Hughes Arttu Jolma Yes None $#ENSP00000301310#ENSG00000018869#ENST00000301310#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2$#ENSP00000465619#ENSG00000018869#ENST00000586929#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2$#ENSP00000483414#ENSG00000018869#ENST00000619584#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2$#ENSP00000465639#ENSG00000018869#ENST00000589895#C2H2 ZF Containing Proteins#KRAB TRUE 759 ENSG00000198440 ZNF583 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR001909;IPR007087;IPR015880; 147949 zinc finger protein 583 [Source:HGNC Symbol;Acc:HGNC:26427] None Full not tested None None b Yes No Yes 4a, two or more datasets predict it as a TF Laura Campitelli Yimeng Yin Yes $#ENSG00000198440#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000388502#ENSG00000198440#ENST00000333201#C2H2 ZF Containing Proteins#KRAB$#ENSP00000291598#ENSG00000198440#ENST00000291598#C2H2 ZF Containing Proteins#KRAB$#ENSP00000444291#ENSG00000198440#ENST00000537943#C2H2 ZF Containing Proteins#KRAB$#ENSP00000375657#ENSG00000198440#ENST00000391778#C2H2 ZF Containing Proteins#KRAB TRUE 760 ENSG00000171574 ZNF584 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 201514 zinc finger protein 584 [Source:HGNC Symbol;Acc:HGNC:27318] None DBD and Full not tested None None b Yes No Yes 1a1, Direct HQ evidence Sam Lambert Arttu Jolma Yes $#ENSG00000171574#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000306756#ENSG00000171574#ENST00000306910#C2H2 ZF Containing Proteins#KRAB$#ENSP00000470404#ENSG00000171574#ENST00000599238#C2H2 ZF Containing Proteins#$#ENSP00000320731#ENSG00000171574#ENST00000322834#C2H2 ZF Containing Proteins#KRAB$#ENSP00000471105#ENSG00000171574#ENST00000593920#C2H2 ZF Containing Proteins#$#ENSP00000472853#ENSG00000171574#ENST00000596281#C2H2 ZF Containing Proteins# TRUE 761 ENSG00000196967 ZNF585A C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 199704 zinc finger protein 585A [Source:HGNC Symbol;Acc:HGNC:26305] None Full not tested None None b Yes No Yes 1a1, Direct HQ evidence Jussi Taipale Yimeng Yin Yes $#ENSG00000196967#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000292841#ENSG00000196967#ENST00000292841#C2H2 ZF Containing Proteins#KRAB$#ENSP00000375998#ENSG00000196967#ENST00000392157#C2H2 ZF Containing Proteins#$#ENSP00000466185#ENSG00000196967#ENST00000588354#C2H2 ZF Containing Proteins#$#ENSP00000349440#ENSG00000196967#ENST00000356958#C2H2 ZF Containing Proteins# TRUE 762 ENSG00000245680 ZNF585B C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR001909;IPR007087;IPR015880;IPR013087 92285 zinc finger protein 585B [Source:HGNC Symbol;Acc:HGNC:30948] None DBD not tested None None b Yes No Yes 4a, two or more datasets predict it as a TF Pratyush Das Laura Campitelli Yes $#ENSG00000245680#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000435268#ENSG00000245680#ENST00000527838#C2H2 ZF Containing Proteins#KRAB$#ENSP00000433773#ENSG00000245680#ENST00000532828#C2H2 ZF Containing Proteins#KRAB$#ENSP00000436774#ENSG00000245680#ENST00000531805#C2H2 ZF Containing Proteins#$#ENSP00000467380#ENSG00000245680#ENST00000586320#C2H2 ZF Containing Proteins#KRAB TRUE 763 ENSG00000083828 ZNF586 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 54807 zinc finger protein 586 [Source:HGNC Symbol;Acc:HGNC:25949] None Full not tested None None b Yes No Yes 1a1, Direct HQ evidence Tim Hughes Yimeng Yin Yes $#ENSG00000083828#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000379454#ENSG00000083828#ENST00000396150#C2H2 ZF Containing Proteins#$#ENSP00000379458#ENSG00000083828#ENST00000396154#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2$#ENSP00000375583#ENSG00000083828#ENST00000391702#C2H2 ZF Containing Proteins#zf-H2C2_2$#ENSP00000472972#ENSG00000083828#ENST00000599802#C2H2 ZF Containing Proteins# TRUE 764 ENSG00000198466 ZNF587 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 84914 zinc finger protein 587 [Source:HGNC Symbol;Acc:HGNC:30955] None Full not tested None None b Yes No No 1a1, Direct HQ evidence Sam Lambert Pratyush Das Yes None $#ENSP00000345479#ENSG00000198466#ENST00000339656#C2H2 ZF Containing Proteins#KRAB, zf-C2H2_4$#ENSP00000393865#ENSG00000198466#ENST00000423137#C2H2 ZF Containing Proteins#KRAB, zf-C2H2_4$#ENSP00000406999#ENSG00000198466#ENST00000419854#C2H2 ZF Containing Proteins#zf-C2H2_4 TRUE 765 ENSG00000269343 ZNF587B C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains and a KRAB-domain IPR001909;IPR007087;IPR015880 100293516 zinc finger protein 587B [Source:HGNC Symbol;Acc:HGNC:37142] None not tested not tested None None No Yes No Yes 4a, two or more datasets predict it as a TF Laura Campitelli Arttu Jolma No $#ENSG00000269343#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000392410#ENSG00000269343#ENST00000442832#C2H2 ZF Containing Proteins#KRAB, zf-C2H2_4, zf-H2C2_2$#ENSP00000472004#ENSG00000269343#ENST00000594328#C2H2 ZF Containing Proteins#$#ENSP00000469623#ENSG00000269343#ENST00000594901#C2H2 ZF Containing Proteins#KRAB TRUE 766 ENSG00000164048 ZNF589 C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain None IPR001909;IPR007087;IPR015880; 51385 zinc finger protein 589 [Source:HGNC Symbol;Acc:HGNC:16747] None DBD and Full not tested None None b Yes No No 2a1, Lower confidence direct evidence Sam Lambert Arttu Jolma Yes None $#ENSP00000346729#ENSG00000164048#ENST00000354698#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2, zinc_ribbon_9$#ENSP00000404398#ENSG00000164048#ENST00000412564#C2H2 ZF Containing Proteins#KRAB$#ENSP00000392719#ENSG00000164048#ENST00000427617#C2H2 ZF Containing Proteins#KRAB$#ENSP00000408719#ENSG00000164048#ENST00000440261#C2H2 ZF Containing Proteins#KRAB TRUE 767 ENSG00000166716 ZNF592 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR007087;IPR015880 9640 zinc finger protein 592 [Source:HGNC Symbol;Acc:HGNC:28986] None DBD and Full not tested None None b Yes No No 4a, two or more datasets predict it as a TF Jussi Taipale Pratyush Das Yes None $#ENSP00000299927#ENSG00000166716#ENST00000299927#C2H2 ZF Containing Proteins#zf-C2H2_11, zf-C2H2_4$#ENSP00000452877#ENSG00000166716#ENST00000560079#C2H2 ZF Containing Proteins#zf-C2H2_11, zf-C2H2_4 FALSE 768 ENSG00000142684 ZNF593 C2H2 ZF No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Protein has a single atypical znfC2H2 domain that has been shown to inhibit binding of POU2F2 to DNA by interacting with POU2F2 (PMID: 18287285). IPR003604;IPR007087;IPR022755; 51042 zinc finger protein 593 [Source:HGNC Symbol;Acc:HGNC:30943] None DBD and Full not tested None None a No No No 5a, one of the source datasets predicts is as a TF Arttu Jolma Pratyush Das No None $#ENSP00000363384#ENSG00000142684#ENST00000374266#C2H2 ZF Containing Proteins#DUF3073, zf-C2H2_2, zf-C2H2_jaz, zf-met$#ENSP00000270812#ENSG00000142684#ENST00000270812#C2H2 ZF Containing Proteins#DUF3073, zf-C2H2_2, zf-C2H2_jaz, zf-met FALSE 769 ENSG00000180626 ZNF594 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR007087;IPR015880 84622 zinc finger protein 594 [Source:HGNC Symbol;Acc:HGNC:29392] None not tested not tested None None c Yes No No 1a1, Direct HQ evidence Sam Lambert Laura Campitelli Yes None $#ENSP00000461696#ENSG00000180626#ENST00000576772#C2H2 ZF Containing Proteins#$#ENSP00000461032#ENSG00000180626#ENST00000575779#C2H2 ZF Containing Proteins#zf-C2H2_6$#ENSP00000382513#ENSG00000180626#ENST00000399604#C2H2 ZF Containing Proteins#zf-C2H2_6 FALSE 770 ENSG00000272602 ZNF595 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 152687 zinc finger protein 595 [Source:HGNC Symbol;Acc:HGNC:27196] None DBD and Full not tested None None b Yes No No 1a1, Direct HQ evidence Sam Lambert Jussi Taipale Yes $#ENSG00000272602#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000434858#ENSG00000272602#ENST00000509152#C2H2 ZF Containing Proteins#KRAB$#ENSP00000477392#ENSG00000272602#ENST00000610261#C2H2 ZF Containing Proteins#KRAB$#ENSP00000476367#ENSG00000272602#ENST00000608255#C2H2 ZF Containing Proteins#$#ENSP00000476408#ENSG00000272602#ENST00000609518#C2H2 ZF Containing Proteins#KRAB FALSE 771 ENSG00000172748 ZNF596 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 169270 zinc finger protein 596 [Source:HGNC Symbol;Acc:HGNC:27268] None DBD and Full not tested None None b Yes No No 1a1, Direct HQ evidence Jussi Taipale Sam Lambert Yes None $#ENSP00000310033#ENSG00000172748#ENST00000308811#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2$#ENSP00000477126#ENSG00000172748#ENST00000522866#C2H2 ZF Containing Proteins#KRAB TRUE 772 ENSG00000167981 ZNF597 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001909;IPR007087;IPR015880; 146434 zinc finger protein 597 [Source:HGNC Symbol;Acc:HGNC:26573] None DBD and Full not tested None None b Yes No No 1a1, Direct HQ evidence Arttu Jolma Laura Campitelli Yes None $#ENSP00000301744#ENSG00000167981#ENST00000301744#C2H2 ZF Containing Proteins#KRAB TRUE 773 ENSG00000167962 ZNF598 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR001841;IPR007087;IPR015880; 90850 Zinc finger protein 598 [Source:HGNC Symbol;Acc:HGNC:28079] None Full not tested None None c No No No 5a, one of the source datasets predicts is as a TF Arttu Jolma Jussi Taipale No None $#ENSP00000455308#ENSG00000167962#ENST00000562103#C2H2 ZF Containing Proteins#$#ENSP00000455882#ENSG00000167962#ENST00000563630#C2H2 ZF Containing Proteins# FALSE 774 ENSG00000153896 ZNF599 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains and a KRAB-domain IPR001909;IPR007087;IPR015880; 148103 zinc finger protein 599 [Source:HGNC Symbol;Acc:HGNC:26408] None DBD and Full not tested None None b Yes No No 4a, two or more datasets predict it as a TF Yimeng Yin Arttu Jolma Yes None $#ENSP00000468446#ENSG00000153896#ENST00000587354#C2H2 ZF Containing Proteins#KRAB$#ENSP00000333802#ENSG00000153896#ENST00000329285#C2H2 ZF Containing Proteins#KRAB$#ENSP00000465262#ENSG00000153896#ENST00000588760#C2H2 ZF Containing Proteins#KRAB TRUE 775 ENSG00000189190 ZNF600 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR001909;IPR007087;IPR015880; 162966 zinc finger protein 600 [Source:HGNC Symbol;Acc:HGNC:30951] None not tested not tested None None b Yes No Yes 4a, two or more datasets predict it as a TF Sam Lambert Jussi Taipale Yes $#ENSG00000189190#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000344791#ENSG00000189190#ENST00000338230#C2H2 ZF Containing Proteins#zf-C2H2_4, zf-H2C2_2, zf-met FALSE 776 ENSG00000196458 ZNF605 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 100289635 zinc finger protein 605 [Source:HGNC Symbol;Acc:HGNC:28068] None DBD and Full not tested None None b Yes No Yes 1a1, Direct HQ evidence Sam Lambert Jussi Taipale Yes $#ENSG00000196458#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000353314#ENSG00000196458#ENST00000360187#C2H2 ZF Containing Proteins#KRAB$#ENSP00000376135#ENSG00000196458#ENST00000392321#C2H2 ZF Containing Proteins#KRAB TRUE 777 ENSG00000166704 ZNF606 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR001909;IPR007087;IPR015880; 80095 zinc finger protein 606 [Source:HGNC Symbol;Acc:HGNC:25879] None DBD and Full not tested None None b Yes No Yes 4a, two or more datasets predict it as a TF Laura Campitelli Jussi Taipale Yes $#ENSG00000166704#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000343617#ENSG00000166704#ENST00000341164#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2$#ENSP00000446972#ENSG00000166704#ENST00000551380#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2$#ENSP00000449865#ENSG00000166704#ENST00000547121#C2H2 ZF Containing Proteins#$#ENSP00000446487#ENSG00000166704#ENST00000547828#C2H2 ZF Containing Proteins#$#ENSP00000447075#ENSG00000166704#ENST00000552184#C2H2 ZF Containing Proteins# TRUE 778 ENSG00000198182 ZNF607 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains and a KRAB-domain IPR001909;IPR007087;IPR015880; 84775 zinc finger protein 607 [Source:HGNC Symbol;Acc:HGNC:28192] None Full not tested None None b Yes No Yes 4a, two or more datasets predict it as a TF Pratyush Das Arttu Jolma Yes $#ENSG00000198182#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000347338#ENSG00000198182#ENST00000355202#C2H2 ZF Containing Proteins#KRAB$#ENSP00000438015#ENSG00000198182#ENST00000395835#C2H2 ZF Containing Proteins#KRAB$#ENSP00000466785#ENSG00000198182#ENST00000590670#C2H2 ZF Containing Proteins#zf-C2H2_6$#ENSP00000468817#ENSG00000198182#ENST00000591664#C2H2 ZF Containing Proteins#KRAB TRUE 779 ENSG00000168916 ZNF608 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif Single C2H2 domain None IPR007087; 57507 zinc finger protein 608 [Source:HGNC Symbol;Acc:HGNC:29238] None DBD and Full not tested None None b No No No 5a, one of the source datasets predicts is as a TF Laura Campitelli Yimeng Yin No None $#ENSP00000307746#ENSG00000168916#ENST00000306315#C2H2 ZF Containing Proteins#$#ENSP00000427657#ENSG00000168916#ENST00000504926#C2H2 ZF Containing Proteins#$#ENSP00000423279#ENSG00000168916#ENST00000509799#C2H2 ZF Containing Proteins#$#ENSP00000421899#ENSG00000168916#ENST00000513986#C2H2 ZF Containing Proteins# FALSE 780 ENSG00000180357 ZNF609 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif Single C2H2 domain None IPR007087; 23060 zinc finger protein 609 [Source:HGNC Symbol;Acc:HGNC:29003] None DBD not tested None None b No No No 5a, one of the source datasets predicts is as a TF Pratyush Das Arttu Jolma No None $#ENSP00000388846#ENSG00000180357#ENST00000416172#C2H2 ZF Containing Proteins#$#ENSP00000316527#ENSG00000180357#ENST00000326648#C2H2 ZF Containing Proteins# FALSE 781 ENSG00000167554 ZNF610 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 162963 zinc finger protein 610 [Source:HGNC Symbol;Acc:HGNC:26687] None DBD and Full not tested None None b Yes No No 1a1, Direct HQ evidence Sam Lambert Yimeng Yin Yes None $#ENSP00000324441#ENSG00000167554#ENST00000321287#C2H2 ZF Containing Proteins#KRAB, Zn-ribbon_8$#ENSP00000383922#ENSG00000167554#ENST00000403906#C2H2 ZF Containing Proteins#KRAB, Zn-ribbon_8$#ENSP00000471021#ENSG00000167554#ENST00000601151#C2H2 ZF Containing Proteins#KRAB, Zn-ribbon_8$#ENSP00000477617#ENSG00000167554#ENST00000613461#C2H2 ZF Containing Proteins#KRAB, Zn-ribbon_8$#ENSP00000327597#ENSG00000167554#ENST00000327920#C2H2 ZF Containing Proteins#KRAB, Zn-ribbon_8$#ENSP00000485001#ENSG00000167554#ENST00000616431#C2H2 ZF Containing Proteins#KRAB, Zn-ribbon_8 TRUE 782 ENSG00000213020 ZNF611 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 81856 zinc finger protein 611 [Source:HGNC Symbol;Acc:HGNC:28766] None DBD and Full not tested None None b Yes No Yes 1a1, Direct HQ evidence Arttu Jolma Jussi Taipale Yes $#ENSG00000213020#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000469376#ENSG00000213020#ENST00000595798#C2H2 ZF Containing Proteins#zf-C2H2_6, zf-C2H2_jaz, zf-H2C2_2, zf-met$#ENSP00000322427#ENSG00000213020#ENST00000319783#C2H2 ZF Containing Proteins#KRAB$#ENSP00000472648#ENSG00000213020#ENST00000602162#C2H2 ZF Containing Proteins#zf-C2H2_6, zf-C2H2_jaz, zf-H2C2_2, zf-met TRUE 783 ENSG00000176024 ZNF613 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 79898 zinc finger protein 613 [Source:HGNC Symbol;Acc:HGNC:25827] None Full not tested None None b Yes No Yes 1a1, Direct HQ evidence Yimeng Yin Laura Campitelli Yes $#ENSG00000176024#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000293471#ENSG00000176024#ENST00000293471#C2H2 ZF Containing Proteins#KRAB$#ENSP00000375671#ENSG00000176024#ENST00000391794#C2H2 ZF Containing Proteins#$#ENSP00000490115#ENSG00000176024#ENST00000601794#C2H2 ZF Containing Proteins#$#ENSP00000472455#ENSG00000176024#ENST00000599683#C2H2 ZF Containing Proteins#KRAB TRUE 784 ENSG00000142556 ZNF614 C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect None IPR001909;IPR007087;IPR015880 80110 zinc finger protein 614 [Source:HGNC Symbol;Acc:HGNC:24722] None DBD and Full not tested None None No Yes No No 1a1, Direct HQ evidence Pratyush Das Jussi Taipale Yes None $#ENSP00000270649#ENSG00000142556#ENST00000270649#C2H2 ZF Containing Proteins#KRAB, zf-C2H2_4, zf-H2C2_2$#ENSP00000348674#ENSG00000142556#ENST00000356322#C2H2 ZF Containing Proteins#KRAB$#ENSP00000469809#ENSG00000142556#ENST00000597952#C2H2 ZF Containing Proteins#KRAB TRUE 785 ENSG00000197619 ZNF615 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 284370 zinc finger protein 615 [Source:HGNC Symbol;Acc:HGNC:24740] None Full not tested None None b Yes No Yes 1a1, Direct HQ evidence Yimeng Yin Laura Campitelli Yes $#ENSG00000197619#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000471549#ENSG00000197619#ENST00000594083#C2H2 ZF Containing Proteins#KRAB$#ENSP00000471041#ENSG00000197619#ENST00000598071#C2H2 ZF Containing Proteins#KRAB$#ENSP00000483676#ENSG00000197619#ENST00000618487#C2H2 ZF Containing Proteins#KRAB$#ENSP00000365906#ENSG00000197619#ENST00000376716#C2H2 ZF Containing Proteins#KRAB$#ENSP00000375672#ENSG00000197619#ENST00000391795#C2H2 ZF Containing Proteins#KRAB TRUE 786 ENSG00000204611 ZNF616 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 90317 zinc finger protein 616 [Source:HGNC Symbol;Acc:HGNC:28062] None Full not tested None None b Yes No Yes 1a1, Direct HQ evidence Arttu Jolma Sam Lambert Yes $#ENSG00000204611#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000328722#ENSG00000204611#ENST00000330123#C2H2 ZF Containing Proteins#KRAB$#ENSP00000471000#ENSG00000204611#ENST00000600228#C2H2 ZF Containing Proteins#KRAB TRUE 787 ENSG00000157657 ZNF618 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR007087;IPR012337;IPR015880; 114991 zinc finger protein 618 [Source:HGNC Symbol;Acc:HGNC:29416] None Full not tested None None b Yes No No 4a, two or more datasets predict it as a TF Sam Lambert Pratyush Das Yes None $#ENSP00000288466#ENSG00000157657#ENST00000288466#C2H2 ZF Containing Proteins#Dimer_Tnp_hAT$#ENSP00000363241#ENSG00000157657#ENST00000374126#C2H2 ZF Containing Proteins#Dimer_Tnp_hAT$#ENSP00000483198#ENSG00000157657#ENST00000615615#C2H2 ZF Containing Proteins#Dimer_Tnp_hAT FALSE 788 ENSG00000177873 ZNF619 C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect None IPR001909;IPR007087;IPR015880; 285267 zinc finger protein 619 [Source:HGNC Symbol;Acc:HGNC:26910] None Full not tested None None b Yes No No 1a1, Direct HQ evidence Pratyush Das Jussi Taipale Yes None $#ENSP00000322529#ENSG00000177873#ENST00000314686#C2H2 ZF Containing Proteins#$#ENSP00000397232#ENSG00000177873#ENST00000456778#C2H2 ZF Containing Proteins# FALSE 789 ENSG00000177842 ZNF620 C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect None IPR001909;IPR007087;IPR015880; 253639 zinc finger protein 620 [Source:HGNC Symbol;Acc:HGNC:28742] None not tested not tested None None b Yes No No 1a1, Direct HQ evidence Pratyush Das Jussi Taipale Yes None $#ENSP00000322265#ENSG00000177842#ENST00000314529#C2H2 ZF Containing Proteins#KRAB$#ENSP00000391472#ENSG00000177842#ENST00000418905#C2H2 ZF Containing Proteins#$#ENSP00000406156#ENSG00000177842#ENST00000420891#C2H2 ZF Containing Proteins#KRAB TRUE 790 ENSG00000172888 ZNF621 C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect None IPR001909;IPR007087;IPR015880; 285268 zinc finger protein 621 [Source:HGNC Symbol;Acc:HGNC:24787] None DBD and Full not tested None None b Yes No Yes 1a1, Direct HQ evidence Sam Lambert Arttu Jolma Yes $#ENSG00000172888#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000340841#ENSG00000172888#ENST00000339296#C2H2 ZF Containing Proteins#KRAB$#ENSP00000386051#ENSG00000172888#ENST00000403205#C2H2 ZF Containing Proteins#KRAB$#ENSP00000413236#ENSG00000172888#ENST00000431278#C2H2 ZF Containing Proteins#$#ENSP00000312144#ENSG00000172888#ENST00000310898#C2H2 ZF Containing Proteins#KRAB TRUE 791 ENSG00000173545 ZNF622 C2H2 ZF No ssDNA/RNA binding Not a DNA binding protein No motif None ZNF622 lacks canonical Pfam matches to C2H2 domains and appears to have better homology to U1-type 1 ZFs involved in RNA recognition. Previous evidence for TF activity (PMID:12645566) was based on transcriptional regulation; and not DNA-binding. IPR003604;IPR007087;IPR015880;IPR022755 90441 zinc finger protein 622 [Source:HGNC Symbol;Acc:HGNC:30958] None DBD and Full not tested None None a No No No 5a, one of the source datasets predicts is as a TF Sam Lambert Laura Campitelli No None $#ENSP00000310042#ENSG00000173545#ENST00000308683#C2H2 ZF Containing Proteins#zf-C2H2_2, zf-C2H2_jaz, zf-met FALSE 792 ENSG00000183309 ZNF623 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR007087;IPR015880 9831 Zinc finger protein 623 [Source:HGNC Symbol;Acc:HGNC:29084] None not tested not tested None None b Yes No No 4a, two or more datasets predict it as a TF Jussi Taipale Laura Campitelli Yes $#ENSG00000183309#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000411139#ENSG00000183309#ENST00000458270#C2H2 ZF Containing Proteins#$#ENSP00000435232#ENSG00000183309#ENST00000526926#C2H2 ZF Containing Proteins#$#ENSP00000445979#ENSG00000183309#ENST00000501748#C2H2 ZF Containing Proteins# FALSE 793 ENSG00000197566 ZNF624 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR001909;IPR007087;IPR015880; 57547 zinc finger protein 624 [Source:HGNC Symbol;Acc:HGNC:29254] None DBD and Full not tested None None b Yes No Yes 4a, two or more datasets predict it as a TF Yimeng Yin Pratyush Das Yes $#ENSG00000197566#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000310472#ENSG00000197566#ENST00000311331#C2H2 ZF Containing Proteins#KRAB$#ENSP00000406525#ENSG00000197566#ENST00000423860#C2H2 ZF Containing Proteins#KRAB$#ENSP00000463295#ENSG00000197566#ENST00000583766#C2H2 ZF Containing Proteins#KRAB TRUE 794 ENSG00000257591 ZNF625 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains and a KRAB-domain None 90589 Zinc finger protein 625 [Source:HGNC Symbol;Acc:HGNC:30571] None not tested not tested None None b Yes No No 4a, two or more datasets predict it as a TF Arttu Jolma Yimeng Yin Yes None $#ENSP00000398518#ENSG00000257591#ENST00000455799#C2H2 ZF Containing Proteins#KRAB$#ENSP00000394380#ENSG00000257591#ENST00000439556#C2H2 ZF Containing Proteins#KRAB$#ENSP00000405156#ENSG00000257591#ENST00000414892#C2H2 ZF Containing Proteins#KRAB FALSE 795 ENSG00000188171 ZNF626 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 199777 zinc finger protein 626 [Source:HGNC Symbol;Acc:HGNC:30461] None Full not tested None None b Yes No No 1a1, Direct HQ evidence Sam Lambert Yimeng Yin Yes None $#ENSP00000291750#ENSG00000188171#ENST00000291750#C2H2 ZF Containing Proteins#KRAB$#ENSP00000469566#ENSG00000188171#ENST00000595405#C2H2 ZF Containing Proteins#$#ENSP00000469958#ENSG00000188171#ENST00000601440#C2H2 ZF Containing Proteins#KRAB$#ENSP00000484232#ENSG00000188171#ENST00000612591#C2H2 ZF Containing Proteins#KRAB TRUE 796 ENSG00000198551 ZNF627 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 199692 zinc finger protein 627 [Source:HGNC Symbol;Acc:HGNC:30570] None Full not tested None None b Yes No No 1a1, Direct HQ evidence Pratyush Das Jussi Taipale Yes None $#ENSP00000354414#ENSG00000198551#ENST00000361113#C2H2 ZF Containing Proteins#KRAB$#ENSP00000465841#ENSG00000198551#ENST00000588174#C2H2 ZF Containing Proteins#KRAB$#ENSP00000464997#ENSG00000198551#ENST00000585493#C2H2 ZF Containing Proteins#$#ENSP00000466068#ENSG00000198551#ENST00000587939#C2H2 ZF Containing Proteins# TRUE 797 ENSG00000197483 ZNF628 C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains. The transfac model doesnt look like a common suspect IPR007087;IPR015880 89887 zinc finger protein 628 [Source:HGNC Symbol;Acc:HGNC:28054] None Full not tested None None b Yes No Yes 2a1, Lower confidence direct evidence Arttu Jolma Pratyush Das Yes $#ENSG00000197483#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000469591#ENSG00000197483#ENST00000598519#C2H2 ZF Containing Proteins#$#ENSP00000465905#ENSG00000197483#ENST00000591164#C2H2 ZF Containing Proteins#$#ENSP00000375598#ENSG00000197483#ENST00000391718#C2H2 ZF Containing Proteins# FALSE 798 ENSG00000102870 ZNF629 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR007087;IPR015880 23361 zinc finger protein 629 [Source:HGNC Symbol;Acc:HGNC:29008] None not tested not tested None None b Yes No Yes 4a, two or more datasets predict it as a TF Tim Hughes Sam Lambert Yes $#ENSG00000102870#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000262525#ENSG00000102870#ENST00000262525#C2H2 ZF Containing Proteins#zf-C2H2_4, zf-C2H2_6, zf-H2C2_2, zinc_ribbon_9 FALSE 799 ENSG00000221994 ZNF630 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR001909;IPR007087;IPR015880; 57232 zinc finger protein 630 [Source:HGNC Symbol;Acc:HGNC:28855] None not tested not tested None None No Yes No Yes 4a, two or more datasets predict it as a TF Pratyush Das Jussi Taipale No $#ENSG00000221994#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000354683#ENSG00000221994#ENST00000276054#C2H2 ZF Containing Proteins#$#ENSP00000386393#ENSG00000221994#ENST00000409324#C2H2 ZF Containing Proteins#KRAB$#ENSP00000485938#ENSG00000221994#ENST00000627643#C2H2 ZF Containing Proteins#KRAB TRUE 800 ENSG00000121864 ZNF639 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Promotes transcription of HIV genes (PMID: 24204263). IPR007087;IPR015880 51193 zinc finger protein 639 [Source:HGNC Symbol;Acc:HGNC:30950] None DBD and Full not tested None None b Yes No Yes 4a, two or more datasets predict it as a TF Yimeng Yin Arttu Jolma Yes $#ENSG00000121864#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:20484494$#ENSG00000121864#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:16182284 $#ENSP00000325634#ENSG00000121864#ENST00000326361#C2H2 ZF Containing Proteins#$#ENSP00000419650#ENSG00000121864#ENST00000466264#C2H2 ZF Containing Proteins#$#ENSP00000417740#ENSG00000121864#ENST00000496856#C2H2 ZF Containing Proteins#$#ENSP00000477626#ENSG00000121864#ENST00000621687#C2H2 ZF Containing Proteins#$#ENSP00000418766#ENSG00000121864#ENST00000484866#C2H2 ZF Containing Proteins#$#ENSP00000418628#ENSG00000121864#ENST00000481587#C2H2 ZF Containing Proteins# FALSE 801 ENSG00000167528 ZNF641 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 121274 zinc finger protein 641 [Source:HGNC Symbol;Acc:HGNC:31834] None Full not tested None None b Yes No Yes 1a1, Direct HQ evidence Sam Lambert Pratyush Das Yes $#ENSG00000167528#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000437832#ENSG00000167528#ENST00000544117#C2H2 ZF Containing Proteins#KRAB$#ENSP00000449974#ENSG00000167528#ENST00000547026#C2H2 ZF Containing Proteins#KRAB$#ENSP00000394627#ENSG00000167528#ENST00000448928#C2H2 ZF Containing Proteins#$#ENSP00000447381#ENSG00000167528#ENST00000550181#C2H2 ZF Containing Proteins# TRUE 802 ENSG00000122482 ZNF644 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Possible false positive. Arrangement of C2H2 domains seems inconsistent with DNA binding. IPR007087;IPR015880 84146 zinc finger protein 644 [Source:HGNC Symbol;Acc:HGNC:29222] None DBD and Full not tested None None a Yes No No 4a, two or more datasets predict it as a TF Tim Hughes Jussi Taipale Yes None $#ENSP00000337008#ENSG00000122482#ENST00000337393#C2H2 ZF Containing Proteins#zf-C2H2_4$#ENSP00000340828#ENSG00000122482#ENST00000347275#C2H2 ZF Containing Proteins#$#ENSP00000354659#ENSG00000122482#ENST00000361321#C2H2 ZF Containing Proteins# FALSE 803 ENSG00000175809 ZNF645 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif Single C2H2 domain None IPR001841;IPR007087;IPR017907; 158506 zinc finger protein 645 [Source:HGNC Symbol;Acc:HGNC:26371] None DBD and Full not tested None None b No No No 5a, one of the source datasets predicts is as a TF Pratyush Das Yimeng Yin No None $#ENSP00000323348#ENSG00000175809#ENST00000323684#C2H2 ZF Containing Proteins#Prok-RING_4, zf-C3HC4, zf-C3HC4_3, zf-RING_5 FALSE 804 ENSG00000167395 ZNF646 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains IPR007087;IPR015880 9726 zinc finger protein 646 [Source:HGNC Symbol;Acc:HGNC:29004] None DBD and Full not tested None None b Yes No No 4a, two or more datasets predict it as a TF Jussi Taipale Arttu Jolma Yes None $#ENSP00000300850#ENSG00000167395#ENST00000300850#C2H2 ZF Containing Proteins#zf-C2H2_4, zf-C2H2_jaz$#ENSP00000456651#ENSG00000167395#ENST00000564189#C2H2 ZF Containing Proteins#$#ENSP00000391271#ENSG00000167395#ENST00000428260#C2H2 ZF Containing Proteins#$#ENSP00000378429#ENSG00000167395#ENST00000394979#C2H2 ZF Containing Proteins#zf-C2H2_4, zf-C2H2_jaz FALSE 805 ENSG00000179930 ZNF648 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR007087;IPR015880 127665 zinc finger protein 648 [Source:HGNC Symbol;Acc:HGNC:18190] None Full not tested None None b Yes No No 4a, two or more datasets predict it as a TF Pratyush Das Yimeng Yin Yes None $#ENSP00000344129#ENSG00000179930#ENST00000339948#C2H2 ZF Containing Proteins# FALSE 806 ENSG00000198093 ZNF649 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 65251 zinc finger protein 649 [Source:HGNC Symbol;Acc:HGNC:25741] None Full not tested None None b Yes No Yes 1a1, Direct HQ evidence Arttu Jolma Jussi Taipale Yes $#ENSG00000198093#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000347043#ENSG00000198093#ENST00000354957#C2H2 ZF Containing Proteins#KRAB$#ENSP00000468983#ENSG00000198093#ENST00000600738#C2H2 ZF Containing Proteins#KRAB$#ENSP00000471756#ENSG00000198093#ENST00000599530#C2H2 ZF Containing Proteins#KRAB$#ENSP00000469690#ENSG00000198093#ENST00000596690#C2H2 ZF Containing Proteins#KRAB TRUE 807 ENSG00000198740 ZNF652 C2H2 ZF Yes Inferred motif Monomer or homomultimer High-throughput in vitro None None IPR007087;IPR015880 22834 zinc finger protein 652 [Source:HGNC Symbol;Acc:HGNC:29147] None Full not tested None Cell paper model is for mouse ortholog Zfp652 b Yes No No 1a1, Direct HQ evidence Laura Campitelli Arttu Jolma Yes None $#ENSP00000354686#ENSG00000198740#ENST00000362063#C2H2 ZF Containing Proteins#$#ENSP00000416305#ENSG00000198740#ENST00000430262#C2H2 ZF Containing Proteins# FALSE 808 ENSG00000175105 ZNF654 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR007087;IPR015880 55279 zinc finger protein 654 [Source:HGNC Symbol;Acc:HGNC:25612] None DBD Yes None None b Yes No No 4a, two or more datasets predict it as a TF Yimeng Yin Sam Lambert Yes None $#ENSP00000312141#ENSG00000175105#ENST00000309495#C2H2 ZF Containing Proteins#$#ENSP00000490842#ENSG00000175105#ENST00000636215#C2H2 ZF Containing Proteins# FALSE 809 ENSG00000197343 ZNF655 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains IPR001909;IPR007087;IPR015880; 79027 zinc finger protein 655 [Source:HGNC Symbol;Acc:HGNC:30899] None DBD and Full not tested None None b Yes No Yes 4a, two or more datasets predict it as a TF Jussi Taipale Arttu Jolma Yes $#ENSG00000197343#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000252713#ENSG00000197343#ENST00000252713#C2H2 ZF Containing Proteins#$#ENSP00000322363#ENSG00000197343#ENST00000320583#C2H2 ZF Containing Proteins#KRAB$#ENSP00000377718#ENSG00000197343#ENST00000394163#C2H2 ZF Containing Proteins#$#ENSP00000350530#ENSG00000197343#ENST00000357864#C2H2 ZF Containing Proteins#$#ENSP00000389260#ENSG00000197343#ENST00000422164#C2H2 ZF Containing Proteins#$#ENSP00000393876#ENSG00000197343#ENST00000424881#C2H2 ZF Containing Proteins#$#ENSP00000396396#ENSG00000197343#ENST00000440391#C2H2 ZF Containing Proteins#$#ENSP00000398872#ENSG00000197343#ENST00000452314#C2H2 ZF Containing Proteins#$#ENSP00000419135#ENSG00000197343#ENST00000493277#C2H2 ZF Containing Proteins#$#ENSP00000392980#ENSG00000197343#ENST00000425063#C2H2 ZF Containing Proteins# FALSE 810 ENSG00000274349 ZNF658 C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source None None IPR001909;IPR007087;IPR015880; 26149 zinc finger protein 658 [Source:HGNC Symbol;Acc:HGNC:25226] None Full not tested None None b Yes No Yes 2a1, Lower confidence direct evidence Yimeng Yin Sam Lambert Yes $#ENSG00000274349#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000482540#ENSG00000274349#ENST00000612867#C2H2 ZF Containing Proteins#KRAB$#ENSP00000482447#ENSG00000274349#ENST00000621410#C2H2 ZF Containing Proteins#KRAB TRUE 811 ENSG00000160229 ZNF66 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR001909;IPR007087;IPR015880 None zinc finger protein 66 [Source:HGNC Symbol;Acc:HGNC:13135] None not tested not tested None None No Yes No No 5a, one of the source datasets predicts is as a TF Sam Lambert Pratyush Das Yes None None FALSE 812 ENSG00000144792 ZNF660 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR007087;IPR015880 285349 zinc finger protein 660 [Source:HGNC Symbol;Acc:HGNC:26720] None DBD and Full not tested None None b Yes No Yes 1a1, Direct HQ evidence Jussi Taipale Pratyush Das Yes $#ENSG00000144792#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000324605#ENSG00000144792#ENST00000322734#C2H2 ZF Containing Proteins#$#ENSP00000405284#ENSG00000144792#ENST00000416644#C2H2 ZF Containing Proteins#$#ENSP00000411996#ENSG00000144792#ENST00000441021#C2H2 ZF Containing Proteins# FALSE 813 ENSG00000182983 ZNF662 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 389114 zinc finger protein 662 [Source:HGNC Symbol;Acc:HGNC:31930] None Full not tested None None b Yes No No 1a1, Direct HQ evidence Sam Lambert Pratyush Das Yes None $#ENSP00000408945#ENSG00000182983#ENST00000422021#C2H2 ZF Containing Proteins#$#ENSP00000405047#ENSG00000182983#ENST00000440367#C2H2 ZF Containing Proteins#$#ENSP00000329264#ENSG00000182983#ENST00000328199#C2H2 ZF Containing Proteins#KRAB TRUE 814 ENSG00000179195 ZNF664 C2H2 ZF Yes Inferred motif Monomer or homomultimer In vivo/Misc source None None IPR007087;IPR015880 144348 zinc finger protein 664 [Source:HGNC Symbol;Acc:HGNC:25406] None DBD and Full not tested None None b Yes No No 2a2, orthologous lower confidence evidence Sam Lambert Pratyush Das Yes None $#ENSP00000337320#ENSG00000179195#ENST00000337815#C2H2 ZF Containing Proteins#$#ENSP00000376205#ENSG00000179195#ENST00000392404#C2H2 ZF Containing Proteins#$#ENSP00000441405#ENSG00000179195#ENST00000539644#C2H2 ZF Containing Proteins#$#ENSP00000440645#ENSG00000179195#ENST00000538932#C2H2 ZF Containing Proteins# FALSE 815 ENSG00000197497 ZNF665 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR001909;IPR007087;IPR015880; 79788 zinc finger protein 665 [Source:HGNC Symbol;Acc:HGNC:25885] None not tested not tested None None b Yes No No 4a, two or more datasets predict it as a TF Sam Lambert Jussi Taipale Yes None $#ENSP00000379702#ENSG00000197497#ENST00000396424#C2H2 ZF Containing Proteins#KRAB$#ENSP00000469154#ENSG00000197497#ENST00000600412#C2H2 ZF Containing Proteins# FALSE 816 ENSG00000198046 ZNF667 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 63934 zinc finger protein 667 [Source:HGNC Symbol;Acc:HGNC:28854] None DBD and Full not tested None None b Yes No No 1a1, Direct HQ evidence Laura Campitelli Arttu Jolma Yes None $#ENSP00000292069#ENSG00000198046#ENST00000292069#C2H2 ZF Containing Proteins#KRAB$#ENSP00000439402#ENSG00000198046#ENST00000504904#C2H2 ZF Containing Proteins#KRAB$#ENSP00000468550#ENSG00000198046#ENST00000591790#C2H2 ZF Containing Proteins#KRAB TRUE 817 ENSG00000167394 ZNF668 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR007087;IPR015880 79759 zinc finger protein 668 [Source:HGNC Symbol;Acc:HGNC:25821] None DBD not tested None None b Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:15539151 No 4a, two or more datasets predict it as a TF Sam Lambert Laura Campitelli Yes $#ENSG00000167394#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000300849#ENSG00000167394#ENST00000300849#C2H2 ZF Containing Proteins#$#ENSP00000416853#ENSG00000167394#ENST00000442862#C2H2 ZF Containing Proteins#$#ENSP00000440149#ENSG00000167394#ENST00000538906#C2H2 ZF Containing Proteins#$#ENSP00000412340#ENSG00000167394#ENST00000414399#C2H2 ZF Containing Proteins#$#ENSP00000390671#ENSG00000167394#ENST00000417935#C2H2 ZF Containing Proteins#zf-H2C2_2 FALSE 818 ENSG00000188295 ZNF669 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 79862 zinc finger protein 669 [Source:HGNC Symbol;Acc:HGNC:25736] None DBD and Full not tested None None b Yes No No 1a1, Direct HQ evidence Laura Campitelli Arttu Jolma Yes None $#ENSP00000342818#ENSG00000188295#ENST00000343381#C2H2 ZF Containing Proteins#KRAB$#ENSP00000404370#ENSG00000188295#ENST00000448299#C2H2 ZF Containing Proteins#KRAB$#ENSP00000355456#ENSG00000188295#ENST00000366500#C2H2 ZF Containing Proteins#KRAB$#ENSP00000355457#ENSG00000188295#ENST00000366501#C2H2 ZF Containing Proteins#KRAB$#ENSP00000429550#ENSG00000188295#ENST00000476158#C2H2 ZF Containing Proteins#KRAB TRUE 819 ENSG00000277462 ZNF670 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Has a nice cassette of znfC2H2 domains and a KRAB domain None None zinc finger protein 670 None not tested not tested None Has a nice cassette of znfC2H2 domains and a KRAB domain No Yes No No Protein added after initial stage, no initial assesment Arttu Jolma Sam Lambert Yes None None FALSE 820 ENSG00000083814 ZNF671 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 79891 zinc finger protein 671 [Source:HGNC Symbol;Acc:HGNC:26279] None DBD and Full not tested None None b Yes No No 1a1, Direct HQ evidence Pratyush Das Laura Campitelli Yes None $#ENSP00000321848#ENSG00000083814#ENST00000317398#C2H2 ZF Containing Proteins#DZR, KRAB, zf-H2C2_2$#ENSP00000468976#ENSG00000083814#ENST00000596939#C2H2 ZF Containing Proteins# TRUE 821 ENSG00000171161 ZNF672 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains IPR007087;IPR015880 79894 zinc finger protein 672 [Source:HGNC Symbol;Acc:HGNC:26179] None DBD and Full not tested None None b Yes No No 4a, two or more datasets predict it as a TF Jussi Taipale Arttu Jolma Yes None $#ENSP00000421915#ENSG00000171161#ENST00000306562#C2H2 ZF Containing Proteins#$#ENSP00000427021#ENSG00000171161#ENST00000428515#C2H2 ZF Containing Proteins#$#ENSP00000422534#ENSG00000171161#ENST00000505503#C2H2 ZF Containing Proteins#$#ENSP00000426199#ENSG00000171161#ENST00000423362#C2H2 ZF Containing Proteins# FALSE 822 ENSG00000251192 ZNF674 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 641339 zinc finger protein 674 [Source:HGNC Symbol;Acc:HGNC:17625] None not tested not tested None None x Yes No No 4a, two or more datasets predict it as a TF Yimeng Yin Jussi Taipale Yes None $#ENSP00000429148#ENSG00000251192#ENST00000523374#C2H2 ZF Containing Proteins#KRAB$#ENSP00000428248#ENSG00000251192#ENST00000414387#C2H2 ZF Containing Proteins#KRAB$#ENSP00000429646#ENSG00000251192#ENST00000518708#C2H2 ZF Containing Proteins#KRAB TRUE 823 ENSG00000197372 ZNF675 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 171392 zinc finger protein 675 [Source:HGNC Symbol;Acc:HGNC:30768] None not tested not tested None None b Yes No Yes 1a1, Direct HQ evidence Arttu Jolma Sam Lambert Yes $#ENSG00000197372#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IDA - PMID:11751921 $#ENSP00000352836#ENSG00000197372#ENST00000359788#C2H2 ZF Containing Proteins#KRAB$#ENSP00000469379#ENSG00000197372#ENST00000601935#C2H2 ZF Containing Proteins#KRAB$#ENSP00000469271#ENSG00000197372#ENST00000599168#C2H2 ZF Containing Proteins#KRAB$#ENSP00000473035#ENSG00000197372#ENST00000599535#C2H2 ZF Containing Proteins# TRUE 824 ENSG00000196109 ZNF676 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR001909;IPR007087;IPR015880; 163223 zinc finger protein 676 [Source:HGNC Symbol;Acc:HGNC:20429] None not tested not tested None None c Yes No No 4a, two or more datasets predict it as a TF Laura Campitelli Yimeng Yin Yes None $#ENSP00000380310#ENSG00000196109#ENST00000397121#C2H2 ZF Containing Proteins#zf-H2C2_2 TRUE 825 ENSG00000197928 ZNF677 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 342926 zinc finger protein 677 [Source:HGNC Symbol;Acc:HGNC:28730] None Full not tested None None b Yes No Yes 1a1, Direct HQ evidence Sam Lambert Arttu Jolma Yes $#ENSG00000197928#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000334394#ENSG00000197928#ENST00000333952#C2H2 ZF Containing Proteins#KRAB$#ENSP00000472416#ENSG00000197928#ENST00000594517#C2H2 ZF Containing Proteins#KRAB$#ENSP00000469391#ENSG00000197928#ENST00000598513#C2H2 ZF Containing Proteins#KRAB$#ENSP00000471071#ENSG00000197928#ENST00000598806#C2H2 ZF Containing Proteins#KRAB$#ENSP00000472132#ENSG00000197928#ENST00000594681#C2H2 ZF Containing Proteins#KRAB$#ENSP00000472783#ENSG00000197928#ENST00000601413#C2H2 ZF Containing Proteins#KRAB$#ENSP00000471266#ENSG00000197928#ENST00000601828#C2H2 ZF Containing Proteins#KRAB$#ENSP00000469701#ENSG00000197928#ENST00000599012#C2H2 ZF Containing Proteins#KRAB TRUE 826 ENSG00000181450 ZNF678 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR001909;IPR007087;IPR015880; 339500 zinc finger protein 678 [Source:HGNC Symbol;Acc:HGNC:28652] None Full not tested None None b Yes No No 4a, two or more datasets predict it as a TF Yimeng Yin Jussi Taipale Yes None $#ENSP00000344828#ENSG00000181450#ENST00000343776#C2H2 ZF Containing Proteins#zf-C2H2_11, zf-C2H2_4, zf-H2C2_2$#ENSP00000440403#ENSG00000181450#ENST00000397097#C2H2 ZF Containing Proteins#zf-C2H2_11, zf-C2H2_4, zf-H2C2_2$#ENSP00000477097#ENSG00000181450#ENST00000608949#C2H2 ZF Containing Proteins#$#ENSP00000394651#ENSG00000181450#ENST00000440339#C2H2 ZF Containing Proteins#KRAB FALSE 827 ENSG00000197123 ZNF679 C2H2 ZF Yes Inferred motif Monomer or homomultimer In vivo/Misc source None None IPR001909;IPR007087;IPR015880; 168417 zinc finger protein 679 [Source:HGNC Symbol;Acc:HGNC:28650] None Full not tested None None b Yes No No 2a2, orthologous lower confidence evidence Yimeng Yin Arttu Jolma Yes None $#ENSP00000255746#ENSG00000197123#ENST00000255746#C2H2 ZF Containing Proteins#BolA, C1_4, KRAB, zf-H2C2_2$#ENSP00000416809#ENSG00000197123#ENST00000421025#C2H2 ZF Containing Proteins#BolA, C1_4, KRAB, zf-H2C2_2 TRUE 828 ENSG00000173041 ZNF680 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 340252 zinc finger protein 680 [Source:HGNC Symbol;Acc:HGNC:26897] None DBD and Full not tested None None b Yes No No 1a1, Direct HQ evidence Laura Campitelli Jussi Taipale Yes None $#ENSP00000309330#ENSG00000173041#ENST00000309683#C2H2 ZF Containing Proteins#KRAB$#ENSP00000393506#ENSG00000173041#ENST00000447137#C2H2 ZF Containing Proteins#KRAB TRUE 829 ENSG00000196172 ZNF681 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 148213 zinc finger protein 681 [Source:HGNC Symbol;Acc:HGNC:26457] None not tested not tested None None b Yes No Yes 1a1, Direct HQ evidence Laura Campitelli Sam Lambert Yes $#ENSG00000196172#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000384000#ENSG00000196172#ENST00000402377#C2H2 ZF Containing Proteins#KRAB$#ENSP00000433806#ENSG00000196172#ENST00000528059#C2H2 ZF Containing Proteins#$#ENSP00000435824#ENSG00000196172#ENST00000531570#C2H2 ZF Containing Proteins# TRUE 830 ENSG00000197124 ZNF682 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 91120 zinc finger protein 682 [Source:HGNC Symbol;Acc:HGNC:28857] None not tested not tested None None b Yes No No 1a1, Direct HQ evidence Jussi Taipale Sam Lambert Yes None $#ENSP00000470718#ENSG00000197124#ENST00000597972#C2H2 ZF Containing Proteins#KRAB$#ENSP00000351324#ENSG00000197124#ENST00000358523#C2H2 ZF Containing Proteins#KRAB$#ENSP00000380351#ENSG00000197124#ENST00000397165#C2H2 ZF Containing Proteins#KRAB$#ENSP00000471717#ENSG00000197124#ENST00000595736#C2H2 ZF Containing Proteins#$#ENSP00000471745#ENSG00000197124#ENST00000594127#C2H2 ZF Containing Proteins# TRUE 831 ENSG00000176083 ZNF683 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR007087;IPR015880 257101 zinc finger protein 683 [Source:HGNC Symbol;Acc:HGNC:28495] None DBD not tested None None b Yes No No 2a2, orthologous lower confidence evidence Pratyush Das Yimeng Yin Yes None $#ENSP00000344095#ENSG00000176083#ENST00000349618#C2H2 ZF Containing Proteins#$#ENSP00000384782#ENSG00000176083#ENST00000403843#C2H2 ZF Containing Proteins#$#ENSP00000391584#ENSG00000176083#ENST00000423508#C2H2 ZF Containing Proteins#$#ENSP00000411290#ENSG00000176083#ENST00000451801#C2H2 ZF Containing Proteins#$#ENSP00000411289#ENSG00000176083#ENST00000455900#C2H2 ZF Containing Proteins#$#ENSP00000401961#ENSG00000176083#ENST00000416125#C2H2 ZF Containing Proteins#$#ENSP00000406734#ENSG00000176083#ENST00000453132#C2H2 ZF Containing Proteins# FALSE 832 ENSG00000117010 ZNF684 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001909;IPR007087;IPR015880; 127396 zinc finger protein 684 [Source:HGNC Symbol;Acc:HGNC:28418] None DBD and Full not tested None None b Yes No No 1a1, Direct HQ evidence Laura Campitelli Pratyush Das Yes None $#ENSP00000361784#ENSG00000117010#ENST00000372699#C2H2 ZF Containing Proteins#KRAB$#ENSP00000361781#ENSG00000117010#ENST00000372696#C2H2 ZF Containing Proteins#KRAB$#ENSP00000361782#ENSG00000117010#ENST00000372697#C2H2 ZF Containing Proteins#KRAB TRUE 833 ENSG00000143373 ZNF687 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR007087;IPR015880 57592 zinc finger protein 687 [Source:HGNC Symbol;Acc:HGNC:29277] None Full not tested None None b Yes No No 4a, two or more datasets predict it as a TF Arttu Jolma Yimeng Yin Yes None $#ENSP00000319829#ENSG00000143373#ENST00000324048#C2H2 ZF Containing Proteins#$#ENSP00000336620#ENSG00000143373#ENST00000336715#C2H2 ZF Containing Proteins#$#ENSP00000395261#ENSG00000143373#ENST00000443959#C2H2 ZF Containing Proteins#$#ENSP00000398821#ENSG00000143373#ENST00000426871#C2H2 ZF Containing Proteins# FALSE 834 ENSG00000229809 ZNF688 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR001909;IPR007087;IPR015880 146542 zinc finger protein 688 [Source:HGNC Symbol;Acc:HGNC:30489] None DBD and Full not tested None Taipale Lab, Unpublished HT-SELEX, direct No Yes No No 1a1, Direct HQ evidence Jussi Taipale Sam Lambert No None $#ENSP00000223459#ENSG00000229809#ENST00000223459#C2H2 ZF Containing Proteins#KRAB$#ENSP00000455227#ENSG00000229809#ENST00000563276#C2H2 ZF Containing Proteins#$#ENSP00000457222#ENSG00000229809#ENST00000567855#C2H2 ZF Containing Proteins#KRAB$#ENSP00000456070#ENSG00000229809#ENST00000563707#C2H2 ZF Containing Proteins#KRAB$#ENSP00000456047#ENSG00000229809#ENST00000566632#C2H2 ZF Containing Proteins# TRUE 835 ENSG00000156853 ZNF689 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains and a KRAB-domain and that it downregulates expression of BCL2 proteins in some types of liver cancer PMID: 21624362 IPR001909;IPR007087;IPR015880; 115509 zinc finger protein 689 [Source:HGNC Symbol;Acc:HGNC:25173] None DBD and Full Yes None None b Yes No No 4a, two or more datasets predict it as a TF Sam Lambert Arttu Jolma Yes None $#ENSP00000287461#ENSG00000156853#ENST00000287461#C2H2 ZF Containing Proteins#KRAB TRUE 836 ENSG00000198429 ZNF69 C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect None IPR001909;IPR007087;IPR015880; 7620 zinc finger protein 69 [Source:HGNC Symbol;Acc:HGNC:13138] None Full not tested None None b Yes No No 1a1, Direct HQ evidence Sam Lambert Jussi Taipale Yes None $#ENSP00000345333#ENSG00000198429#ENST00000340180#C2H2 ZF Containing Proteins#KRAB$#ENSP00000402985#ENSG00000198429#ENST00000429654#C2H2 ZF Containing Proteins#KRAB$#ENSP00000388784#ENSG00000198429#ENST00000445911#C2H2 ZF Containing Proteins#KRAB TRUE 837 ENSG00000164011 ZNF691 C2H2 ZF Yes Inferred motif Monomer or homomultimer High-throughput in vitro None None IPR007087;IPR015880 51058 Zinc finger protein 691 [Source:HGNC Symbol;Acc:HGNC:28028] None not tested not tested None None b Yes No No 1a2, Orthologous HQ evidence Matt Weirauch Sam Lambert Yes $#ENSG00000164011#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000361586#ENSG00000164011#ENST00000372508#C2H2 ZF Containing Proteins#$#ENSP00000361580#ENSG00000164011#ENST00000372502#C2H2 ZF Containing Proteins#$#ENSP00000361581#ENSG00000164011#ENST00000372503#C2H2 ZF Containing Proteins#$#ENSP00000361584#ENSG00000164011#ENST00000372506#C2H2 ZF Containing Proteins#$#ENSP00000361585#ENSG00000164011#ENST00000372507#C2H2 ZF Containing Proteins#$#ENSP00000380228#ENSG00000164011#ENST00000397034#C2H2 ZF Containing Proteins#$#ENSP00000486871#ENSG00000164011#ENST00000630961#C2H2 ZF Containing Proteins# FALSE 838 ENSG00000171163 ZNF692 C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect None IPR007087;IPR015880 55657 zinc finger protein 692 [Source:HGNC Symbol;Acc:HGNC:26049] None DBD and Full not tested None None b Yes No No 1a1, Direct HQ evidence Jussi Taipale Laura Campitelli Yes None $#ENSP00000305483#ENSG00000171163#ENST00000306601#C2H2 ZF Containing Proteins#$#ENSP00000355427#ENSG00000171163#ENST00000366471#C2H2 ZF Containing Proteins#$#ENSP00000391200#ENSG00000171163#ENST00000451251#C2H2 ZF Containing Proteins#$#ENSP00000431582#ENSG00000171163#ENST00000476503#C2H2 ZF Containing Proteins#$#ENSP00000432300#ENSG00000171163#ENST00000496231#C2H2 ZF Containing Proteins# FALSE 839 ENSG00000197472 ZNF695 C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect None IPR001909;IPR007087;IPR015880; 57116 zinc finger protein 695 [Source:HGNC Symbol;Acc:HGNC:30954] None DBD and Full not tested None None b Yes No No 1a1, Direct HQ evidence Yimeng Yin Laura Campitelli Yes None $#ENSP00000341236#ENSG00000197472#ENST00000339986#C2H2 ZF Containing Proteins#KRAB, Zn-ribbon_8, zf-C2H2_6, zf-H2C2_2$#ENSP00000429736#ENSG00000197472#ENST00000487338#C2H2 ZF Containing Proteins#KRAB TRUE 840 ENSG00000185730 ZNF696 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR007087;IPR015880 79943 zinc finger protein 696 [Source:HGNC Symbol;Acc:HGNC:25872] None DBD and Full not tested None None b Yes No Yes 4a, two or more datasets predict it as a TF Jussi Taipale Sam Lambert Yes $#ENSG00000185730#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000328515#ENSG00000185730#ENST00000330143#C2H2 ZF Containing Proteins#$#ENSP00000429859#ENSG00000185730#ENST00000521537#C2H2 ZF Containing Proteins#$#ENSP00000427857#ENSG00000185730#ENST00000518575#C2H2 ZF Containing Proteins# FALSE 841 ENSG00000143067 ZNF697 C2H2 ZF Yes Inferred motif Monomer or homomultimer In vivo/Misc source None None IPR007087;IPR015880 90874 zinc finger protein 697 [Source:HGNC Symbol;Acc:HGNC:32034] None DBD and Full not tested None None b Yes No No 2a2, orthologous lower confidence evidence Arttu Jolma Pratyush Das Yes None $#ENSP00000396857#ENSG00000143067#ENST00000421812#C2H2 ZF Containing Proteins# FALSE 842 ENSG00000196110 ZNF699 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains and a KRAB-domain IPR001909;IPR007087;IPR015880; 374879 zinc finger protein 699 [Source:HGNC Symbol;Acc:HGNC:24750] None DBD and Full not tested None None b Yes No Yes 4a, two or more datasets predict it as a TF Arttu Jolma Pratyush Das Yes $#ENSG00000196110#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000311596#ENSG00000196110#ENST00000308650#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2$#ENSP00000467723#ENSG00000196110#ENST00000591998#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2 TRUE 843 ENSG00000147789 ZNF7 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 7553 zinc finger protein 7 [Source:HGNC Symbol;Acc:HGNC:13139] None not tested not tested None None a Yes No Yes 1a1, Direct HQ evidence Yimeng Yin Sam Lambert Yes $#ENSG00000147789#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000393260#ENSG00000147789#ENST00000446747#C2H2 ZF Containing Proteins#KRAB$#ENSP00000432724#ENSG00000147789#ENST00000528372#C2H2 ZF Containing Proteins#KRAB$#ENSP00000432641#ENSG00000147789#ENST00000532777#C2H2 ZF Containing Proteins#KRAB$#ENSP00000435252#ENSG00000147789#ENST00000525266#C2H2 ZF Containing Proteins#KRAB$#ENSP00000439424#ENSG00000147789#ENST00000544249#C2H2 ZF Containing Proteins# TRUE 844 ENSG00000187792 ZNF70 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR007087;IPR015880 7621 zinc finger protein 70 [Source:HGNC Symbol;Acc:HGNC:13140] None DBD and Full not tested None None b Yes No No 4a, two or more datasets predict it as a TF Laura Campitelli Sam Lambert Yes None $#ENSP00000339314#ENSG00000187792#ENST00000341976#C2H2 ZF Containing Proteins# FALSE 845 ENSG00000196757 ZNF700 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR001909;IPR007087;IPR015880; 90592 zinc finger protein 700 [Source:HGNC Symbol;Acc:HGNC:25292] None Full not tested None None b Yes No No 4a, two or more datasets predict it as a TF Sam Lambert Pratyush Das Yes None $#ENSP00000254321#ENSG00000196757#ENST00000254321#C2H2 ZF Containing Proteins#KRAB$#ENSP00000467996#ENSG00000196757#ENST00000482090#C2H2 ZF Containing Proteins#KRAB$#ENSP00000479449#ENSG00000196757#ENST00000622593#C2H2 ZF Containing Proteins#KRAB TRUE 846 ENSG00000167562 ZNF701 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 55762 zinc finger protein 701 [Source:HGNC Symbol;Acc:HGNC:25597] None Full not tested None None b Yes No No 1a1, Direct HQ evidence Pratyush Das Sam Lambert Yes None $#ENSP00000301093#ENSG00000167562#ENST00000301093#C2H2 ZF Containing Proteins#KRAB, zf-C2H2_6$#ENSP00000375662#ENSG00000167562#ENST00000391785#C2H2 ZF Containing Proteins#KRAB, zf-C2H2_6$#ENSP00000444339#ENSG00000167562#ENST00000540331#C2H2 ZF Containing Proteins#KRAB, zf-C2H2_6$#ENSP00000471080#ENSG00000167562#ENST00000593941#C2H2 ZF Containing Proteins#KRAB TRUE 847 ENSG00000183779 ZNF703 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif Single C2H2 domain None IPR007087;IPR022129 80139 zinc finger protein 703 [Source:HGNC Symbol;Acc:HGNC:25883] None DBD and Full not tested None None b Yes No No 4a, two or more datasets predict it as a TF Yimeng Yin Pratyush Das No None $#ENSP00000332325#ENSG00000183779#ENST00000331569#C2H2 ZF Containing Proteins#nlz1 FALSE 848 ENSG00000164684 ZNF704 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro Single C2H2 domain None IPR007087; 619279 zinc finger protein 704 [Source:HGNC Symbol;Acc:HGNC:32291] None DBD and Full not tested None None b Yes No No 1a1, Direct HQ evidence Yimeng Yin Sam Lambert No None $#ENSP00000331462#ENSG00000164684#ENST00000327835#C2H2 ZF Containing Proteins#$#ENSP00000427715#ENSG00000164684#ENST00000519936#C2H2 ZF Containing Proteins# FALSE 849 ENSG00000196946 ZNF705A C2H2 ZF Yes Inferred motif Monomer or homomultimer In vivo/Misc source None Contains decent cassette of znfC2H2 domains and a KRAB-domain. IPR001909;IPR007087;IPR015880; 100131539 zinc finger protein 705A [Source:HGNC Symbol;Acc:HGNC:32281] None Full not tested None None b Yes No No 2a2, orthologous lower confidence evidence Laura Campitelli Arttu Jolma Yes None $#ENSP00000352233#ENSG00000196946#ENST00000359286#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2$#ENSP00000384896#ENSG00000196946#ENST00000402465#C2H2 ZF Containing Proteins#KRAB$#ENSP00000475525#ENSG00000196946#ENST00000398526#C2H2 ZF Containing Proteins# TRUE 850 ENSG00000215356 ZNF705B C2H2 ZF Yes Inferred motif Monomer or homomultimer In vivo/Misc source None None IPR001909;IPR007087;IPR015880; 100132396 zinc finger protein 705B [Source:HGNC Symbol;Acc:HGNC:32284] None not tested not tested None None c Yes No No 2a2, orthologous lower confidence evidence Pratyush Das Sam Lambert No None $#ENSP00000382987#ENSG00000215356#ENST00000400120#C2H2 ZF Containing Proteins#KRAB TRUE 851 ENSG00000215343 ZNF705D C2H2 ZF Yes Inferred motif Monomer or homomultimer In vivo/Misc source None None IPR001909;IPR007087;IPR015880; 728957 zinc finger protein 705D [Source:HGNC Symbol;Acc:HGNC:33202] None Full not tested None None b Yes No No 2a2, orthologous lower confidence evidence Jussi Taipale Pratyush Das Yes None $#ENSP00000445477#ENSG00000215343#ENST00000400078#C2H2 ZF Containing Proteins#KRAB$#ENSP00000382957#ENSG00000215343#ENST00000400085#C2H2 ZF Containing Proteins#KRAB TRUE 852 ENSG00000214534 ZNF705E C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Has a nice cassette of znfC2H2 domains and a KRAB domain None None zinc finger protein 705E None DBD not tested None Has a nice cassette of znfC2H2 domains and a KRAB domain No No No No Protein added after initial stage, no initial assesment Arttu Jolma Sam Lambert Yes None None FALSE 853 ENSG00000215372 ZNF705G C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect None IPR001909;IPR007087;IPR015880; 100131980 zinc finger protein 705G [Source:HGNC Symbol;Acc:HGNC:37134] None not tested not tested None None b Yes No No 1a1, Direct HQ evidence Yimeng Yin Jussi Taipale Yes None $#ENSP00000383020#ENSG00000215372#ENST00000400156#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2 TRUE 854 ENSG00000120963 ZNF706 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif Single C2H2 domain None IPR007513; 51123 zinc finger protein 706 [Source:HGNC Symbol;Acc:HGNC:24992] None DBD and Full not tested None Has no ZNFs b No No No 5a, one of the source datasets predicts is as a TF Pratyush Das Matt Weirauch No None $#ENSP00000311768#ENSG00000120963#ENST00000311212#Other#4F5, zf-C2H2_jaz, zf-met$#ENSP00000430823#ENSG00000120963#ENST00000520347#Other#4F5, zf-C2H2_jaz, zf-met$#ENSP00000428227#ENSG00000120963#ENST00000517844#Other#4F5, zf-C2H2_jaz, zf-met$#ENSP00000427803#ENSG00000120963#ENST00000519103#Other#$#ENSP00000429645#ENSG00000120963#ENST00000519744#Other#4F5$#ENSP00000428985#ENSG00000120963#ENST00000519882#Other#4F5, zf-C2H2_jaz, zf-met$#ENSP00000430090#ENSG00000120963#ENST00000520454#Other#$#ENSP00000429260#ENSG00000120963#ENST00000523922#Other#4F5 FALSE 855 ENSG00000181135 ZNF707 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 101928160 zinc finger protein 707 [Source:HGNC Symbol;Acc:HGNC:27815] None DBD and Full not tested None None b Yes No No 1a1, Direct HQ evidence Yimeng Yin Laura Campitelli Yes None $#ENSP00000413215#ENSG00000181135#ENST00000418203#C2H2 ZF Containing Proteins#KRAB$#ENSP00000436250#ENSG00000181135#ENST00000532158#C2H2 ZF Containing Proteins#KRAB$#ENSP00000351482#ENSG00000181135#ENST00000358656#C2H2 ZF Containing Proteins#KRAB$#ENSP00000436212#ENSG00000181135#ENST00000532205#C2H2 ZF Containing Proteins#KRAB$#ENSP00000437134#ENSG00000181135#ENST00000534303#C2H2 ZF Containing Proteins#KRAB TRUE 856 ENSG00000182141 ZNF708 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 7562 Zinc finger protein 708 [Source:HGNC Symbol;Acc:HGNC:12945] None not tested not tested None None a Yes No No 1a1, Direct HQ evidence Sam Lambert Laura Campitelli Yes None $#ENSP00000349401#ENSG00000182141#ENST00000356929#C2H2 ZF Containing Proteins#KRAB$#ENSP00000469961#ENSG00000182141#ENST00000601295#C2H2 ZF Containing Proteins#$#ENSP00000471855#ENSG00000182141#ENST00000602023#C2H2 ZF Containing Proteins# FALSE 857 ENSG00000242852 ZNF709 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR001909;IPR007087;IPR015880; 163051 zinc finger protein 709 [Source:HGNC Symbol;Acc:HGNC:20629] None DBD not tested None None b Yes No No 4a, two or more datasets predict it as a TF Yimeng Yin Sam Lambert Yes None $#ENSP00000380840#ENSG00000242852#ENST00000397732#C2H2 ZF Containing Proteins#KRAB$#ENSP00000398085#ENSG00000242852#ENST00000455490#C2H2 ZF Containing Proteins#KRAB TRUE 858 ENSG00000197951 ZNF71 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR007087;IPR015880 58491 zinc finger protein 71 [Source:HGNC Symbol;Acc:HGNC:13141] None Full not tested None None b Yes No Yes 1a1, Direct HQ evidence Laura Campitelli Pratyush Das Yes $#ENSG00000197951#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000328245#ENSG00000197951#ENST00000328070#C2H2 ZF Containing Proteins#$#ENSP00000471138#ENSG00000197951#ENST00000599599#C2H2 ZF Containing Proteins# FALSE 859 ENSG00000140548 ZNF710 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Virtually nothing is known about this protein except that it has a nice array of znfC2H2 domains IPR007087;IPR015880 374655 zinc finger protein 710 [Source:HGNC Symbol;Acc:HGNC:25352] None DBD and Full not tested None None b Yes No No 4a, two or more datasets predict it as a TF Yimeng Yin Arttu Jolma Yes None $#ENSP00000268154#ENSG00000140548#ENST00000268154#C2H2 ZF Containing Proteins#$#ENSP00000453404#ENSG00000140548#ENST00000558883#C2H2 ZF Containing Proteins#$#ENSP00000453147#ENSG00000140548#ENST00000559360#C2H2 ZF Containing Proteins#$#ENSP00000452993#ENSG00000140548#ENST00000559419#C2H2 ZF Containing Proteins# FALSE 860 ENSG00000147180 ZNF711 C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source None None IPR006794;IPR007087;IPR015880; 7552 zinc finger protein 711 [Source:HGNC Symbol;Acc:HGNC:13128] None not tested not tested None None b Yes No Yes 1a1, Direct HQ evidence Sam Lambert Arttu Jolma Yes $#ENSG00000147180#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000276123#ENSG00000147180#ENST00000276123#C2H2 ZF Containing Proteins#Zfx_Zfy_act, zf-C2H2_4, zf-H2C2_5$#ENSP00000353922#ENSG00000147180#ENST00000360700#C2H2 ZF Containing Proteins#Zfx_Zfy_act, zf-C2H2_4, zf-H2C2_5$#ENSP00000362260#ENSG00000147180#ENST00000373165#C2H2 ZF Containing Proteins#Zfx_Zfy_act, zf-C2H2_4, zf-H2C2_5 FALSE 861 ENSG00000178665 ZNF713 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001909;IPR007087;IPR015880; 349075 zinc finger protein 713 [Source:HGNC Symbol;Acc:HGNC:22043] None DBD and Full not tested None None b Yes No No 1a1, Direct HQ evidence Sam Lambert Yimeng Yin Yes None $#ENSP00000487818#ENSG00000178665#ENST00000633730#C2H2 ZF Containing Proteins#KRAB$#ENSP00000416662#ENSG00000178665#ENST00000429591#C2H2 ZF Containing Proteins#KRAB TRUE 862 ENSG00000160352 ZNF714 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 148206 Zinc finger protein 714 [Source:HGNC Symbol;Acc:HGNC:27124] None DBD not tested None None b Yes No No 1a1, Direct HQ evidence Laura Campitelli Arttu Jolma Yes None $#ENSP00000480816#ENSG00000160352#ENST00000620627#C2H2 ZF Containing Proteins#KRAB$#ENSP00000478345#ENSG00000160352#ENST00000456283#C2H2 ZF Containing Proteins#$#ENSP00000469616#ENSG00000160352#ENST00000596053#C2H2 ZF Containing Proteins#KRAB$#ENSP00000484576#ENSG00000160352#ENST00000618008#C2H2 ZF Containing Proteins#KRAB$#ENSP00000484530#ENSG00000160352#ENST00000618422#C2H2 ZF Containing Proteins#zf-H2C2_2 TRUE 863 ENSG00000182111 ZNF716 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 441234 zinc finger protein 716 [Source:HGNC Symbol;Acc:HGNC:32458] None not tested not tested None None c Yes No No 1a1, Direct HQ evidence Yimeng Yin Arttu Jolma Yes None $#ENSP00000394248#ENSG00000182111#ENST00000420713#C2H2 ZF Containing Proteins#BolA, KRAB, zf-H2C2_2 TRUE 864 ENSG00000227124 ZNF717 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR001909 100131827 Zinc finger protein 717 [Source:HGNC Symbol;Acc:HGNC:29448] None not tested not tested None None c Yes No No 4a, two or more datasets predict it as a TF Sam Lambert Pratyush Das Yes $#ENSG00000227124#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000417902#ENSG00000227124#ENST00000477374#C2H2 ZF Containing Proteins#KRAB$#ENSP00000418187#ENSG00000227124#ENST00000468296#C2H2 ZF Containing Proteins#KRAB$#ENSP00000420241#ENSG00000227124#ENST00000471541#C2H2 ZF Containing Proteins#$#ENSP00000419377#ENSG00000227124#ENST00000478296#C2H2 ZF Containing Proteins# TRUE 865 ENSG00000250312 ZNF718 C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain None IPR001909;IPR007087;IPR015880 255403 zinc finger protein 718 [Source:HGNC Symbol;Acc:HGNC:26889] None Full not tested None None No Yes No No 2a1, Lower confidence direct evidence Sam Lambert Yimeng Yin Yes None $#ENSP00000480556#ENSG00000250312#ENST00000510175#C2H2 ZF Containing Proteins#KRAB$#ENSP00000476435#ENSG00000250312#ENST00000609714#C2H2 ZF Containing Proteins#KRAB FALSE 866 ENSG00000182903 ZNF721 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains and a KRAB-domain IPR001909;IPR007087;IPR015880; 170960 zinc finger protein 721 [Source:HGNC Symbol;Acc:HGNC:29425] None not tested not tested None None b Yes No No 4a, two or more datasets predict it as a TF Sam Lambert Arttu Jolma Yes None $#ENSP00000421325#ENSG00000182903#ENST00000505900#C2H2 ZF Containing Proteins#KRAB$#ENSP00000340524#ENSG00000182903#ENST00000338977#C2H2 ZF Containing Proteins#zf-C2H2_6$#ENSP00000423586#ENSG00000182903#ENST00000506646#C2H2 ZF Containing Proteins#KRAB$#ENSP00000428878#ENSG00000182903#ENST00000511833#C2H2 ZF Containing Proteins#zf-C2H2_6 FALSE 867 ENSG00000196081 ZNF724 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains and a KRAB-domain. IPR001909;IPR007087;IPR015880; None zinc finger protein 724, pseudogene [Source:HGNC Symbol;Acc:HGNC:32460] None not tested not tested None None c Yes No No 4a, two or more datasets predict it as a TF Yimeng Yin Arttu Jolma Yes None $#ENSP00000413411#ENSG00000196081#ENST00000418100#C2H2 ZF Containing Proteins#KRAB$#ENSP00000471547#ENSG00000196081#ENST00000597037#C2H2 ZF Containing Proteins#KRAB$#ENSP00000473253#ENSG00000196081#ENST00000597537#C2H2 ZF Containing Proteins#KRAB TRUE 868 ENSG00000213967 ZNF726 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains and a KRAB-domain IPR001909;IPR007087;IPR015880; 730087 zinc finger protein 726 [Source:HGNC Symbol;Acc:HGNC:32462] None not tested not tested None None b Yes No No 4a, two or more datasets predict it as a TF Arttu Jolma Yimeng Yin Yes $#ENSG00000213967#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000432583#ENSG00000213967#ENST00000531821#C2H2 ZF Containing Proteins#KRAB$#ENSP00000461349#ENSG00000213967#ENST00000575986#C2H2 ZF Containing Proteins#KRAB$#ENSP00000433319#ENSG00000213967#ENST00000525354#C2H2 ZF Containing Proteins#KRAB$#ENSP00000334762#ENSG00000213967#ENST00000334589#C2H2 ZF Containing Proteins#KRAB TRUE 869 ENSG00000214652 ZNF727 C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain None IPR001909;IPR007087;IPR015880 442319 zinc finger protein 727 [Source:HGNC Symbol;Acc:HGNC:22785] None not tested not tested None None No Yes No No 2a1, Lower confidence direct evidence Pratyush Das Jussi Taipale Yes None $#ENSP00000485448#ENSG00000214652#ENST00000456806#C2H2 ZF Containing Proteins#KRAB TRUE 870 ENSG00000269067 ZNF728 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains and a KRAB-domain IPR001909;IPR007087;IPR015880 388523 zinc finger protein 728 [Source:HGNC Symbol;Acc:HGNC:32463] None not tested not tested None None No Yes No Yes 4a, two or more datasets predict it as a TF Jussi Taipale Arttu Jolma No $#ENSG00000269067#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000470208#ENSG00000269067#ENST00000599851#C2H2 ZF Containing Proteins#$#ENSP00000471593#ENSG00000269067#ENST00000594710#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2 TRUE 871 ENSG00000196350 ZNF729 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains and a KRAB-domain IPR001909;IPR007087;IPR015880; 100287226 zinc finger protein 729 [Source:HGNC Symbol;Acc:HGNC:32464] None not tested not tested None None b Yes No No 4a, two or more datasets predict it as a TF Pratyush Das Arttu Jolma Yes None $#ENSP00000469582#ENSG00000196350#ENST00000601693#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2 TRUE 872 ZNF73_HUMAN ZNF73 C2H2 ZF No Unlikely to be sequence specific TF Not a DNA binding protein No motif Pseudogene; Only known motifs are from Transfac or HocoMoco - origin is uncertain Pseudogene None None zinc finger protein 73 None not tested not tested None Pseudogene No Yes No No Protein added after initial stage, no initial assesment Arttu Jolma Sam Lambert Yes None None FALSE 873 ENSG00000183850 ZNF730 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 100129543 zinc finger protein 730 [Source:HGNC Symbol;Acc:HGNC:32470] None not tested not tested None None b Yes No No 1a1, Direct HQ evidence Laura Campitelli Arttu Jolma Yes None $#ENSP00000469853#ENSG00000183850#ENST00000593635#C2H2 ZF Containing Proteins#$#ENSP00000472959#ENSG00000183850#ENST00000597761#C2H2 ZF Containing Proteins#KRAB$#ENSP00000469805#ENSG00000183850#ENST00000599195#C2H2 ZF Containing Proteins# TRUE 874 ENSG00000186777 ZNF732 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR001909;IPR007087;IPR015880; 654254 zinc finger protein 732 [Source:HGNC Symbol;Acc:HGNC:37138] None not tested not tested None None c Yes No No 4a, two or more datasets predict it as a TF Jussi Taipale Pratyush Das Yes None $#ENSP00000415774#ENSG00000186777#ENST00000419098#C2H2 ZF Containing Proteins#KRAB$#ENSP00000478210#ENSG00000186777#ENST00000619749#C2H2 ZF Containing Proteins#KRAB TRUE 875 ENSG00000223614 ZNF735 C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain None IPR001909;IPR007087;IPR015880 730291 zinc finger protein 735 [Source:HGNC Symbol;Acc:HGNC:32466] None not tested not tested None None No Yes No No 2a1, Lower confidence direct evidence Sam Lambert Pratyush Das Yes None $#ENSP00000485547#ENSG00000223614#ENST00000429565#C2H2 ZF Containing Proteins#KRAB TRUE 876 ENSG00000234444 ZNF736 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 728927 zinc finger protein 736 [Source:HGNC Symbol;Acc:HGNC:32467] None not tested not tested None TFs that are in CisBP but not in Vaquerizas set No Yes No No 1a1, Direct HQ evidence Laura Campitelli Arttu Jolma Yes None $#ENSP00000400852#ENSG00000234444#ENST00000423484#C2H2 ZF Containing Proteins#KRAB$#ENSP00000347210#ENSG00000234444#ENST00000355095#C2H2 ZF Containing Proteins#KRAB$#ENSP00000391083#ENSG00000234444#ENST00000438373#C2H2 ZF Containing Proteins# TRUE 877 ENSG00000237440 ZNF737 C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect None IPR001909;IPR007087;IPR015880 100129842 zinc finger protein 737 [Source:HGNC Symbol;Acc:HGNC:32468] None not tested not tested None None No Yes No No 1a1, Direct HQ evidence Arttu Jolma Pratyush Das Yes None $#ENSP00000395733#ENSG00000237440#ENST00000427401#C2H2 ZF Containing Proteins#KRAB$#ENSP00000471995#ENSG00000237440#ENST00000596530#C2H2 ZF Containing Proteins#$#ENSP00000471784#ENSG00000237440#ENST00000594419#C2H2 ZF Containing Proteins#$#ENSP00000471973#ENSG00000237440#ENST00000596797#C2H2 ZF Containing Proteins#KRAB TRUE 878 ENSG00000185252 ZNF74 C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect None IPR001909;IPR007087;IPR015880; 7625 zinc finger protein 74 [Source:HGNC Symbol;Acc:HGNC:13144] None Full not tested None None b Yes No Yes 1a1, Direct HQ evidence Yimeng Yin Jussi Taipale Yes $#ENSG00000185252#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000350101#ENSG00000185252#ENST00000357502#C2H2 ZF Containing Proteins#$#ENSP00000383301#ENSG00000185252#ENST00000400451#C2H2 ZF Containing Proteins#KRAB$#ENSP00000384750#ENSG00000185252#ENST00000403682#C2H2 ZF Containing Proteins#$#ENSP00000483077#ENSG00000185252#ENST00000611540#C2H2 ZF Containing Proteins#KRAB TRUE 879 ENSG00000139651 ZNF740 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR007087;IPR015880 283337 zinc finger protein 740 [Source:HGNC Symbol;Acc:HGNC:27465] None DBD and Full Yes None None b Yes No No 1a1, Direct HQ evidence Pratyush Das Laura Campitelli Yes None $#ENSP00000409463#ENSG00000139651#ENST00000416904#C2H2 ZF Containing Proteins# FALSE 880 ENSG00000181220 ZNF746 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR001909;IPR007087;IPR015880;IPR022137 155061 zinc finger protein 746 [Source:HGNC Symbol;Acc:HGNC:21948] None DBD and Full not tested None None b Yes No Yes 4a, two or more datasets predict it as a TF Yimeng Yin Sam Lambert Yes $#ENSG00000181220#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:21376232$#ENSG00000181220#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:21376232 $#ENSP00000345140#ENSG00000181220#ENST00000340622#C2H2 ZF Containing Proteins#DUF3669, KRAB$#ENSP00000420329#ENSG00000181220#ENST00000461958#C2H2 ZF Containing Proteins#DUF3669, KRAB$#ENSP00000395007#ENSG00000181220#ENST00000458143#C2H2 ZF Containing Proteins#DUF3669, KRAB TRUE 881 ENSG00000169955 ZNF747 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR001909;IPR007087;IPR015880; 65988 zinc finger protein 747 [Source:HGNC Symbol;Acc:HGNC:28350] None not tested not tested None None b Yes No No 4a, two or more datasets predict it as a TF Pratyush Das Yimeng Yin No None $#ENSP00000252799#ENSG00000169955#ENST00000252799#C2H2 ZF Containing Proteins#KRAB$#ENSP00000378528#ENSG00000169955#ENST00000395094#C2H2 ZF Containing Proteins#KRAB$#ENSP00000457274#ENSG00000169955#ENST00000568028#C2H2 ZF Containing Proteins#KRAB TRUE 882 ENSG00000186230 ZNF749 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 388567 zinc finger protein 749 [Source:HGNC Symbol;Acc:HGNC:32783] None not tested not tested None None b Yes No No 1a1, Direct HQ evidence Pratyush Das Jussi Taipale Yes None $#ENSP00000333980#ENSG00000186230#ENST00000334181#C2H2 ZF Containing Proteins#KRAB$#ENSP00000397745#ENSG00000186230#ENST00000415248#C2H2 ZF Containing Proteins# TRUE 883 ENSG00000141579 ZNF750 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif Single C2H2 domain; Has a putative AT-hook Influences KLF4 expression (PMID: 22364861). None 79755 zinc finger protein 750 [Source:HGNC Symbol;Acc:HGNC:25843] None DBD and Full not tested None None b No No Yes 4a, two or more datasets predict it as a TF Laura Campitelli Pratyush Das No $#ENSG00000141579#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:22364861 $#ENSP00000269394#ENSG00000141579#ENST00000269394#C2H2 ZF Containing Proteins#zf-C2H2_7$#ENSP00000458389#ENSG00000141579#ENST00000572562#C2H2 ZF Containing Proteins# FALSE 884 ENSG00000162086 ZNF75A C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001909;IPR003309;IPR007087;IPR008916;IPR015880; 7627 zinc finger protein 75a [Source:HGNC Symbol;Acc:HGNC:13146] None DBD and Full not tested None None b Yes No No 1a1, Direct HQ evidence Arttu Jolma Jussi Taipale Yes None $#ENSP00000482769#ENSG00000162086#ENST00000617839#C2H2 ZF Containing Proteins#KRAB$#ENSP00000459566#ENSG00000162086#ENST00000574298#C2H2 ZF Containing Proteins#KRAB$#ENSP00000459707#ENSG00000162086#ENST00000572999#C2H2 ZF Containing Proteins#KRAB$#ENSP00000483325#ENSG00000162086#ENST00000612186#C2H2 ZF Containing Proteins#SCAN TRUE 885 ENSG00000186376 ZNF75D C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR003309;IPR007087;IPR008916;IPR015880; 7626 zinc finger protein 75D [Source:HGNC Symbol;Acc:HGNC:13145] None Full not tested None None b Yes No Yes 1a1, Direct HQ evidence Laura Campitelli Pratyush Das Yes $#ENSG00000186376#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000359802#ENSG00000186376#ENST00000370766#C2H2 ZF Containing Proteins#KRAB, SCAN$#ENSP00000359800#ENSG00000186376#ENST00000370764#C2H2 ZF Containing Proteins#KRAB, SCAN TRUE 886 ENSG00000065029 ZNF76 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR007087;IPR015880 7629 zinc finger protein 76 [Source:HGNC Symbol;Acc:HGNC:13149] None DBD and Full not tested None None a Yes No No 1a1, Direct HQ evidence Pratyush Das Sam Lambert Yes None $#ENSP00000344097#ENSG00000065029#ENST00000339411#C2H2 ZF Containing Proteins#CopK$#ENSP00000363064#ENSG00000065029#ENST00000373953#C2H2 ZF Containing Proteins#CopK$#ENSP00000418749#ENSG00000065029#ENST00000498555#C2H2 ZF Containing Proteins#$#ENSP00000419106#ENSG00000065029#ENST00000469195#C2H2 ZF Containing Proteins#CopK FALSE 887 ENSG00000160336 ZNF761 C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain None IPR001909;IPR007087;IPR015880; 388561 zinc finger protein 761 [Source:HGNC Symbol;Acc:HGNC:23179] None DBD not tested None None b Yes No No 2a1, Lower confidence direct evidence Sam Lambert Jussi Taipale Yes $#ENSG00000160336#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000480218#ENSG00000160336#ENST00000432094#C2H2 ZF Containing Proteins#KRAB$#ENSP00000481316#ENSG00000160336#ENST00000610928#C2H2 ZF Containing Proteins#KRAB$#ENSP00000481271#ENSG00000160336#ENST00000613950#C2H2 ZF Containing Proteins#KRAB$#ENSP00000482214#ENSG00000160336#ENST00000334095#C2H2 ZF Containing Proteins# FALSE 888 ENSG00000197054 ZNF763 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR001909;IPR007087;IPR015880; 284390 zinc finger protein 763 [Source:HGNC Symbol;Acc:HGNC:27614] None Full not tested None None c Yes No No 4a, two or more datasets predict it as a TF Laura Campitelli Yimeng Yin Yes None $#ENSP00000402017#ENSG00000197054#ENST00000358987#C2H2 ZF Containing Proteins#KRAB, zf-C2H2_4, zf-H2C2_2$#ENSP00000369774#ENSG00000197054#ENST00000343949#C2H2 ZF Containing Proteins#KRAB, zf-C2H2_4, zf-H2C2_2$#ENSP00000468692#ENSG00000197054#ENST00000481745#C2H2 ZF Containing Proteins#KRAB$#ENSP00000465145#ENSG00000197054#ENST00000586494#C2H2 ZF Containing Proteins#zf-C2H2_4, zf-C2H2_6, zf-H2C2_2 TRUE 889 ENSG00000169951 ZNF764 C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect None IPR001909;IPR007087;IPR015880; 92595 zinc finger protein 764 [Source:HGNC Symbol;Acc:HGNC:28200] None not tested not tested None None c Yes No No 1a1, Direct HQ evidence Sam Lambert Arttu Jolma Yes None $#ENSP00000252797#ENSG00000169951#ENST00000252797#C2H2 ZF Containing Proteins#KRAB$#ENSP00000378526#ENSG00000169951#ENST00000395091#C2H2 ZF Containing Proteins#KRAB TRUE 890 ENSG00000196417 ZNF765 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 91661 zinc finger protein 765 [Source:HGNC Symbol;Acc:HGNC:25092] None DBD not tested None None b Yes No No 1a1, Direct HQ evidence Sam Lambert Yimeng Yin Yes None $#ENSP00000379689#ENSG00000196417#ENST00000396408#C2H2 ZF Containing Proteins#KRAB$#ENSP00000421579#ENSG00000196417#ENST00000505866#C2H2 ZF Containing Proteins#$#ENSP00000470468#ENSG00000196417#ENST00000594030#C2H2 ZF Containing Proteins#KRAB TRUE 891 ENSG00000196214 ZNF766 C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect None IPR001909;IPR007087;IPR015880; 90321 zinc finger protein 766 [Source:HGNC Symbol;Acc:HGNC:28063] None not tested not tested None None c Yes No No 1a1, Direct HQ evidence Pratyush Das Yimeng Yin Yes None $#ENSP00000409652#ENSG00000196214#ENST00000439461#C2H2 ZF Containing Proteins#KRAB$#ENSP00000468950#ENSG00000196214#ENST00000593612#C2H2 ZF Containing Proteins#KRAB, zf-C2H2_6$#ENSP00000471965#ENSG00000196214#ENST00000599581#C2H2 ZF Containing Proteins#KRAB TRUE 892 ENSG00000169957 ZNF768 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR000684;IPR007087;IPR015880; 79724 zinc finger protein 768 [Source:HGNC Symbol;Acc:HGNC:26273] None not tested not tested None None c Yes No No 1a1, Direct HQ evidence Sam Lambert Arttu Jolma Yes None $#ENSP00000369777#ENSG00000169957#ENST00000380412#C2H2 ZF Containing Proteins#RNA_pol_Rpb1_R$#ENSP00000456527#ENSG00000169957#ENST00000562803#C2H2 ZF Containing Proteins#RNA_pol_Rpb1_R FALSE 893 ENSG00000175691 ZNF77 C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect None IPR001909;IPR007087;IPR015880; 58492 zinc finger protein 77 [Source:HGNC Symbol;Acc:HGNC:13150] None DBD not tested None None b Yes No No 1a1, Direct HQ evidence Sam Lambert Jussi Taipale Yes None $#ENSP00000319053#ENSG00000175691#ENST00000314531#C2H2 ZF Containing Proteins#KRAB TRUE 894 ENSG00000198146 ZNF770 C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect None IPR007087;IPR015880 54989 zinc finger protein 770 [Source:HGNC Symbol;Acc:HGNC:26061] None not tested not tested None None c Yes No Yes 1a1, Direct HQ evidence Jussi Taipale Yimeng Yin Yes $#ENSG00000198146#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000348673#ENSG00000198146#ENST00000356321#C2H2 ZF Containing Proteins#$#ENSP00000453474#ENSG00000198146#ENST00000559564#C2H2 ZF Containing Proteins# FALSE 895 ENSG00000179965 ZNF771 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR007087;IPR015880 51333 zinc finger protein 771 [Source:HGNC Symbol;Acc:HGNC:29653] None DBD and Full not tested None None b Yes No No 1a1, Direct HQ evidence Yimeng Yin Laura Campitelli Yes None $#ENSP00000323945#ENSG00000179965#ENST00000319296#C2H2 ZF Containing Proteins#DNA_RNApol_7kD, Zn-ribbon_8$#ENSP00000460549#ENSG00000179965#ENST00000566625#C2H2 ZF Containing Proteins#$#ENSP00000416197#ENSG00000179965#ENST00000434417#C2H2 ZF Containing Proteins#DNA_RNApol_7kD, Zn-ribbon_8$#ENSP00000456456#ENSG00000179965#ENST00000564550#C2H2 ZF Containing Proteins# FALSE 896 ENSG00000197128 ZNF772 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR001909;IPR007087;IPR015880; 400720 zinc finger protein 772 [Source:HGNC Symbol;Acc:HGNC:33106] None Full not tested None None c Yes No Yes 4a, two or more datasets predict it as a TF Yimeng Yin Pratyush Das Yes $#ENSG00000197128#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000341165#ENSG00000197128#ENST00000343280#C2H2 ZF Containing Proteins#KRAB$#ENSP00000395967#ENSG00000197128#ENST00000427512#C2H2 ZF Containing Proteins#$#ENSP00000348992#ENSG00000197128#ENST00000356584#C2H2 ZF Containing Proteins#KRAB$#ENSP00000415214#ENSG00000197128#ENST00000425074#C2H2 ZF Containing Proteins#$#ENSP00000471079#ENSG00000197128#ENST00000600175#C2H2 ZF Containing Proteins#$#ENSP00000471647#ENSG00000197128#ENST00000601768#C2H2 ZF Containing Proteins# TRUE 897 ENSG00000152439 ZNF773 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains and a KRAB-domain IPR001909;IPR007087;IPR015880; 374928 zinc finger protein 773 [Source:HGNC Symbol;Acc:HGNC:30487] None not tested not tested None None c Yes No Yes 4a, two or more datasets predict it as a TF Yimeng Yin Arttu Jolma Yes $#ENSG00000152439#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000282292#ENSG00000152439#ENST00000282292#C2H2 ZF Containing Proteins#KRAB$#ENSP00000469416#ENSG00000152439#ENST00000598770#C2H2 ZF Containing Proteins#KRAB$#ENSP00000468846#ENSG00000152439#ENST00000599847#C2H2 ZF Containing Proteins#KRAB$#ENSP00000470189#ENSG00000152439#ENST00000593916#C2H2 ZF Containing Proteins#KRAB TRUE 898 ENSG00000196391 ZNF774 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR007087;IPR015880 342132 zinc finger protein 774 [Source:HGNC Symbol;Acc:HGNC:33108] None not tested not tested None None c Yes No No 1a1, Direct HQ evidence Laura Campitelli Jussi Taipale Yes None $#ENSP00000346348#ENSG00000196391#ENST00000354377#C2H2 ZF Containing Proteins#$#ENSP00000368383#ENSG00000196391#ENST00000379090#C2H2 ZF Containing Proteins#$#ENSP00000454184#ENSG00000196391#ENST00000558586#C2H2 ZF Containing Proteins# TRUE 899 ENSG00000196456 ZNF775 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains and a MBD domain IPR007087;IPR015880 285971 zinc finger protein 775 [Source:HGNC Symbol;Acc:HGNC:28501] None Full not tested None None c Yes No No 4a, two or more datasets predict it as a TF Arttu Jolma Jussi Taipale Yes None $#ENSP00000330838#ENSG00000196456#ENST00000329630#C2H2 ZF Containing Proteins#$#ENSP00000417483#ENSG00000196456#ENST00000490973#C2H2 ZF Containing Proteins#$#ENSP00000489517#ENSG00000196456#ENST00000498682#C2H2 ZF Containing Proteins#$#ENSP00000419336#ENSG00000196456#ENST00000478789#C2H2 ZF Containing Proteins# FALSE 900 ENSG00000152443 ZNF776 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 284309 zinc finger protein 776 [Source:HGNC Symbol;Acc:HGNC:26765] None Full not tested None None c Yes No No 1a1, Direct HQ evidence Laura Campitelli Arttu Jolma Yes None $#ENSP00000321812#ENSG00000152443#ENST00000317178#C2H2 ZF Containing Proteins#KRAB$#ENSP00000416901#ENSG00000152443#ENST00000451849#C2H2 ZF Containing Proteins#KRAB$#ENSP00000405772#ENSG00000152443#ENST00000431353#C2H2 ZF Containing Proteins#KRAB TRUE 901 ENSG00000196453 ZNF777 C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect None IPR001909;IPR007087;IPR015880;IPR022137 27153 Zinc finger protein 777 [Source:HGNC Symbol;Acc:HGNC:22213] None Full not tested None None b Yes No No 1a1, Direct HQ evidence Arttu Jolma Pratyush Das Yes None $#ENSP00000247930#ENSG00000196453#ENST00000247930#C2H2 ZF Containing Proteins#DUF3669, KRAB TRUE 902 ENSG00000170100 ZNF778 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 197320 zinc finger protein 778 [Source:HGNC Symbol;Acc:HGNC:26479] None Full not tested None None c Yes No No 1a1, Direct HQ evidence Sam Lambert Arttu Jolma Yes None $#ENSP00000305203#ENSG00000170100#ENST00000306502#C2H2 ZF Containing Proteins#$#ENSP00000481538#ENSG00000170100#ENST00000620195#C2H2 ZF Containing Proteins#KRAB$#ENSP00000457800#ENSG00000170100#ENST00000564906#C2H2 ZF Containing Proteins#KRAB$#ENSP00000405289#ENSG00000170100#ENST00000433976#C2H2 ZF Containing Proteins#KRAB TRUE 903 ENSG00000197782 ZNF780A C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 284323 zinc finger protein 780A [Source:HGNC Symbol;Acc:HGNC:27603] None not tested not tested None None c Yes No Yes 1a1, Direct HQ evidence Yimeng Yin Jussi Taipale Yes $#ENSG00000197782#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000341507#ENSG00000197782#ENST00000340963#C2H2 ZF Containing Proteins#KRAB$#ENSP00000416294#ENSG00000197782#ENST00000414720#C2H2 ZF Containing Proteins#KRAB$#ENSP00000387705#ENSG00000197782#ENST00000450241#C2H2 ZF Containing Proteins#$#ENSP00000469786#ENSG00000197782#ENST00000594395#C2H2 ZF Containing Proteins#KRAB$#ENSP00000472189#ENSG00000197782#ENST00000595687#C2H2 ZF Containing Proteins#KRAB$#ENSP00000469905#ENSG00000197782#ENST00000599972#C2H2 ZF Containing Proteins#KRAB TRUE 904 ENSG00000128000 ZNF780B C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR001909;IPR007087;IPR015880; 163131 zinc finger protein 780B [Source:HGNC Symbol;Acc:HGNC:33109] None not tested not tested None None c Yes No Yes 4a, two or more datasets predict it as a TF Tim Hughes Sam Lambert Yes $#ENSG00000128000#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000221355#ENSG00000128000#ENST00000221355#C2H2 ZF Containing Proteins#$#ENSP00000471669#ENSG00000128000#ENST00000598845#C2H2 ZF Containing Proteins#KRAB$#ENSP00000471501#ENSG00000128000#ENST00000593605#C2H2 ZF Containing Proteins#KRAB TRUE 905 ENSG00000196381 ZNF781 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR007087;IPR015880 163115 zinc finger protein 781 [Source:HGNC Symbol;Acc:HGNC:26745] None Full not tested None None c Yes No No 4a, two or more datasets predict it as a TF Sam Lambert Laura Campitelli Yes None $#ENSP00000351391#ENSG00000196381#ENST00000358582#C2H2 ZF Containing Proteins#$#ENSP00000466370#ENSG00000196381#ENST00000590008#C2H2 ZF Containing Proteins# FALSE 906 ENSG00000196597 ZNF782 C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect None IPR001909;IPR007087;IPR015880; 158431 zinc finger protein 782 [Source:HGNC Symbol;Acc:HGNC:33110] None Full not tested None None c Yes No Yes 1a1, Direct HQ evidence Laura Campitelli Sam Lambert Yes $#ENSG00000196597#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000419397#ENSG00000196597#ENST00000481138#C2H2 ZF Containing Proteins#KRAB$#ENSP00000440624#ENSG00000196597#ENST00000535338#C2H2 ZF Containing Proteins#KRAB$#ENSP00000418686#ENSG00000196597#ENST00000289032#C2H2 ZF Containing Proteins#$#ENSP00000417577#ENSG00000196597#ENST00000478850#C2H2 ZF Containing Proteins#KRAB TRUE 907 ENSG00000204946 ZNF783 C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect None IPR001909;IPR007087;IPR015880;IPR022137 100289678 zinc finger family member 783 [Source:HGNC Symbol;Acc:HGNC:27222] None Full not tested None None b Yes No No 1a1, Direct HQ evidence Jussi Taipale Pratyush Das No None $#ENSP00000410890#ENSG00000204946#ENST00000434415#C2H2 ZF Containing Proteins#DUF3669, KRAB TRUE 908 ENSG00000179922 ZNF784 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR007087;IPR015880 147808 zinc finger protein 784 [Source:HGNC Symbol;Acc:HGNC:33111] None Full not tested None None c Yes No No 1a1, Direct HQ evidence Pratyush Das Jussi Taipale Yes None $#ENSP00000320096#ENSG00000179922#ENST00000325351#C2H2 ZF Containing Proteins#zf-C2H2_4$#ENSP00000467725#ENSG00000179922#ENST00000591479#C2H2 ZF Containing Proteins# FALSE 909 ENSG00000197162 ZNF785 C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect None IPR001909;IPR007087;IPR015880; 146540 zinc finger protein 785 [Source:HGNC Symbol;Acc:HGNC:26496] None DBD and Full not tested None None b Yes No No 1a1, Direct HQ evidence Jussi Taipale Arttu Jolma Yes None $#ENSP00000378642#ENSG00000197162#ENST00000395216#C2H2 ZF Containing Proteins#KRAB$#ENSP00000458511#ENSG00000197162#ENST00000567773#C2H2 ZF Containing Proteins#KRAB$#ENSP00000420340#ENSG00000197162#ENST00000470110#C2H2 ZF Containing Proteins#KRAB TRUE 910 ENSG00000197362 ZNF786 C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect None IPR001909;IPR007087;IPR015880; 136051 zinc finger protein 786 [Source:HGNC Symbol;Acc:HGNC:21806] None Full not tested None None c Yes No No 1a1, Direct HQ evidence Jussi Taipale Sam Lambert Yes None $#ENSP00000313516#ENSG00000197362#ENST00000316286#C2H2 ZF Containing Proteins#zf-H2C2_2$#ENSP00000417470#ENSG00000197362#ENST00000491431#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2 TRUE 911 ENSG00000142409 ZNF787 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR007087;IPR015880 126208 zinc finger protein 787 [Source:HGNC Symbol;Acc:HGNC:26998] None Full not tested None None c Yes No No 1a1, Direct HQ evidence Sam Lambert Jussi Taipale Yes None $#ENSP00000471514#ENSG00000142409#ENST00000586787#C2H2 ZF Containing Proteins#$#ENSP00000478557#ENSG00000142409#ENST00000610935#C2H2 ZF Containing Proteins#zinc_ribbon_9$#ENSP00000465647#ENSG00000142409#ENST00000587279#C2H2 ZF Containing Proteins# FALSE 912 ENSG00000214189 ZNF788 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains None None Zinc finger family member 788 [Source:HGNC Symbol;Acc:HGNC:33112] None not tested not tested None None c Yes No No 4a, two or more datasets predict it as a TF Sam Lambert Arttu Jolma Yes None $#ENSP00000391703#ENSG00000214189#ENST00000430298#C2H2 ZF Containing Proteins#KRAB$#ENSP00000473243#ENSG00000214189#ENST00000596883#C2H2 ZF Containing Proteins#KRAB$#ENSP00000380866#ENSG00000214189#ENST00000397759#C2H2 ZF Containing Proteins#zf-C2H2_4, zf-C2H2_6 FALSE 913 ENSG00000198556 ZNF789 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 285989 zinc finger protein 789 [Source:HGNC Symbol;Acc:HGNC:27801] None Full not tested None None c Yes No Yes 1a1, Direct HQ evidence Jussi Taipale Pratyush Das Yes $#ENSG00000198556#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000331927#ENSG00000198556#ENST00000331410#C2H2 ZF Containing Proteins#KRAB$#ENSP00000405206#ENSG00000198556#ENST00000448667#C2H2 ZF Containing Proteins#KRAB$#ENSP00000417227#ENSG00000198556#ENST00000483089#C2H2 ZF Containing Proteins#KRAB$#ENSP00000369047#ENSG00000198556#ENST00000379724#C2H2 ZF Containing Proteins#KRAB TRUE 914 ENSG00000196152 ZNF79 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 7633 zinc finger protein 79 [Source:HGNC Symbol;Acc:HGNC:13153] None DBD and Full not tested None None b Yes No Yes 1a1, Direct HQ evidence Laura Campitelli Yimeng Yin Yes $#ENSG00000196152#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000362446#ENSG00000196152#ENST00000342483#C2H2 ZF Containing Proteins#$#ENSP00000438418#ENSG00000196152#ENST00000543471#C2H2 ZF Containing Proteins#$#ENSP00000478201#ENSG00000196152#ENST00000612342#C2H2 ZF Containing Proteins#$#ENSP00000484833#ENSG00000196152#ENST00000617266#C2H2 ZF Containing Proteins# TRUE 915 ENSG00000197863 ZNF790 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 388536 zinc finger protein 790 [Source:HGNC Symbol;Acc:HGNC:33114] None not tested not tested None None c Yes No Yes 1a1, Direct HQ evidence Laura Campitelli Pratyush Das Yes $#ENSG00000197863#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000349161#ENSG00000197863#ENST00000356725#C2H2 ZF Containing Proteins#KRAB$#ENSP00000433389#ENSG00000197863#ENST00000525288#C2H2 ZF Containing Proteins#KRAB$#ENSP00000435944#ENSG00000197863#ENST00000528994#C2H2 ZF Containing Proteins#KRAB$#ENSP00000480834#ENSG00000197863#ENST00000614179#C2H2 ZF Containing Proteins#KRAB TRUE 916 ENSG00000173875 ZNF791 C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect None IPR001909;IPR007087;IPR015880; 163049 zinc finger protein 791 [Source:HGNC Symbol;Acc:HGNC:26895] None Full not tested None None c Yes No No 1a1, Direct HQ evidence Sam Lambert Yimeng Yin Yes None $#ENSP00000342974#ENSG00000173875#ENST00000343325#C2H2 ZF Containing Proteins#KRAB$#ENSP00000412981#ENSG00000173875#ENST00000446165#C2H2 ZF Containing Proteins#KRAB$#ENSP00000471179#ENSG00000173875#ENST00000600752#C2H2 ZF Containing Proteins# TRUE 917 ENSG00000180884 ZNF792 C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect None IPR001909;IPR007087;IPR015880; 126375 zinc finger protein 792 [Source:HGNC Symbol;Acc:HGNC:24751] None Full not tested None None c Yes No Yes 1a1, Direct HQ evidence Jussi Taipale Pratyush Das Yes $#ENSG00000180884#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000474130#ENSG00000180884#ENST00000605484#C2H2 ZF Containing Proteins#$#ENSP00000385099#ENSG00000180884#ENST00000404801#C2H2 ZF Containing Proteins#KRAB TRUE 918 ENSG00000188227 ZNF793 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 390927 zinc finger protein 793 [Source:HGNC Symbol;Acc:HGNC:33115] None not tested not tested None None c Yes No Yes 1a1, Direct HQ evidence Arttu Jolma Laura Campitelli Yes $#ENSG00000188227#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000466645#ENSG00000188227#ENST00000587986#C2H2 ZF Containing Proteins#KRAB$#ENSP00000467919#ENSG00000188227#ENST00000588578#C2H2 ZF Containing Proteins#KRAB$#ENSP00000468286#ENSG00000188227#ENST00000586138#C2H2 ZF Containing Proteins#KRAB$#ENSP00000465900#ENSG00000188227#ENST00000587490#C2H2 ZF Containing Proteins#KRAB TRUE 919 ENSG00000196466 ZNF799 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 90576 zinc finger protein 799 [Source:HGNC Symbol;Acc:HGNC:28071] None not tested not tested None None c Yes No No 1a1, Direct HQ evidence Yimeng Yin Arttu Jolma Yes None $#ENSP00000415278#ENSG00000196466#ENST00000419318#C2H2 ZF Containing Proteins#$#ENSP00000411084#ENSG00000196466#ENST00000430385#C2H2 ZF Containing Proteins#KRAB$#ENSP00000471169#ENSG00000196466#ENST00000595766#C2H2 ZF Containing Proteins# TRUE 920 ENSG00000278129 ZNF8 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 7554 Zinc finger protein 8 [Source:HGNC Symbol;Acc:HGNC:13154] None DBD and Full not tested None None b Yes TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI; Transactivation_PMIDS:12370310 Yes 1a1, Direct HQ evidence Pratyush Das Sam Lambert Yes $#ENSG00000278129#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000477716#ENSG00000278129#ENST00000621650#C2H2 ZF Containing Proteins#KRAB TRUE 921 ENSG00000174255 ZNF80 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains. IPR007087;IPR015880 7634 zinc finger protein 80 [Source:HGNC Symbol;Acc:HGNC:13155] None DBD and Full not tested None Taipale Lab, Unpublished HT-SELEX, direct b Yes No No 1a1, Direct HQ evidence Yimeng Yin Arttu Jolma Yes None $#ENSP00000483565#ENSG00000174255#ENST00000619534#C2H2 ZF Containing Proteins#$#ENSP00000417192#ENSG00000174255#ENST00000482457#C2H2 ZF Containing Proteins# FALSE 922 ENSG00000048405 ZNF800 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None C2H2 domains are not arranged in the stereotypic array fashion; but there are several of them. IPR007087;IPR015880 168850 zinc finger protein 800 [Source:HGNC Symbol;Acc:HGNC:27267] None Full not tested None None c Yes No No 4a, two or more datasets predict it as a TF Tim Hughes Sam Lambert Yes None $#ENSP00000265827#ENSG00000048405#ENST00000265827#C2H2 ZF Containing Proteins#zf-C2H2_assoc2, zf-H2C2_2$#ENSP00000389776#ENSG00000048405#ENST00000439506#C2H2 ZF Containing Proteins#$#ENSP00000401109#ENSG00000048405#ENST00000436992#C2H2 ZF Containing Proteins# FALSE 923 ENSG00000170396 ZNF804A C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif Single C2H2 domain None IPR007087;IPR022755 91752 zinc finger protein 804A [Source:HGNC Symbol;Acc:HGNC:21711] None Full not tested None None c No No No 5a, one of the source datasets predicts is as a TF Laura Campitelli Jussi Taipale No None $#ENSP00000303252#ENSG00000170396#ENST00000302277#C2H2 ZF Containing Proteins#zf-C2H2_jaz$#ENSP00000483032#ENSG00000170396#ENST00000613975#C2H2 ZF Containing Proteins# FALSE 924 ENSG00000182348 ZNF804B C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif Single C2H2 domain Jaz domain suggests RNA-binding activity IPR007087;IPR022755 219578 zinc finger protein 804B [Source:HGNC Symbol;Acc:HGNC:21958] None Full not tested None None c No No No 5a, one of the source datasets predicts is as a TF Sam Lambert Jussi Taipale No None $#ENSP00000329638#ENSG00000182348#ENST00000333190#C2H2 ZF Containing Proteins#zf-C2H2_jaz$#ENSP00000478506#ENSG00000182348#ENST00000611114#C2H2 ZF Containing Proteins# FALSE 925 ENSG00000204524 ZNF805 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 390980 zinc finger protein 805 [Source:HGNC Symbol;Acc:HGNC:23272] None not tested not tested None None x Yes No No 1a1, Direct HQ evidence Sam Lambert Arttu Jolma Yes None $#ENSP00000365414#ENSG00000204524#ENST00000354309#C2H2 ZF Containing Proteins#$#ENSP00000412999#ENSG00000204524#ENST00000414468#C2H2 ZF Containing Proteins#KRAB TRUE 926 ENSG00000198482 ZNF808 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 388558 zinc finger protein 808 [Source:HGNC Symbol;Acc:HGNC:33230] None Full not tested None None c Yes No Yes 1a1, Direct HQ evidence Laura Campitelli Arttu Jolma Yes $#ENSG00000198482#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000479648#ENSG00000198482#ENST00000611267#C2H2 ZF Containing Proteins#$#ENSP00000419291#ENSG00000198482#ENST00000465448#C2H2 ZF Containing Proteins#KRAB$#ENSP00000418528#ENSG00000198482#ENST00000486474#C2H2 ZF Containing Proteins# TRUE 927 ENSG00000197779 ZNF81 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 347344 zinc finger protein 81 [Source:HGNC Symbol;Acc:HGNC:13156] None Full not tested None None b Yes No Yes 1a1, Direct HQ evidence Pratyush Das Arttu Jolma Yes $#ENSG00000197779#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000334641#ENSG00000197779#ENST00000334937#C2H2 ZF Containing Proteins#KRAB$#ENSP00000341151#ENSG00000197779#ENST00000338637#C2H2 ZF Containing Proteins#KRAB$#ENSP00000366149#ENSG00000197779#ENST00000376950#C2H2 ZF Containing Proteins#KRAB$#ENSP00000366153#ENSG00000197779#ENST00000376954#C2H2 ZF Containing Proteins#KRAB TRUE 928 ENSG00000224689 ZNF812P C2H2 ZF No Unlikely to be sequence specific TF Not a DNA binding protein No motif Pseudogene None IPR001909;IPR007087;IPR015880; None zinc finger protein 812, pseudogene [Source:HGNC Symbol;Acc:HGNC:33242] None not tested not tested None None No Yes No No 5a, one of the source datasets predicts is as a TF Yimeng Yin Jussi Taipale Yes None $#ENSP00000440451#ENSG00000224689#ENST00000453792#C2H2 ZF Containing Proteins#KRAB FALSE 929 ENSG00000198346 ZNF813 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Has a nice cassette of znfC2H2 domains and a KRAB domain IPR001909;IPR007087;IPR015880; 126017 zinc finger protein 813 [Source:HGNC Symbol;Acc:HGNC:33257] None not tested not tested None None x Yes No No 4a, two or more datasets predict it as a TF Pratyush Das Jussi Taipale Yes None $#ENSP00000379684#ENSG00000198346#ENST00000396403#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2$#ENSP00000418289#ENSG00000198346#ENST00000490956#C2H2 ZF Containing Proteins#KRAB$#ENSP00000419821#ENSG00000198346#ENST00000468450#C2H2 ZF Containing Proteins# TRUE 930 ENSG00000204514 ZNF814 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR001909;IPR007087;IPR015880; 730051 zinc finger protein 814 [Source:HGNC Symbol;Acc:HGNC:33258] None not tested not tested None None x Yes No Yes 4a, two or more datasets predict it as a TF Pratyush Das Sam Lambert Yes $#ENSG00000204514#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000470328#ENSG00000204514#ENST00000596604#C2H2 ZF Containing Proteins#KRAB$#ENSP00000472089#ENSG00000204514#ENST00000600634#C2H2 ZF Containing Proteins#KRAB$#ENSP00000410545#ENSG00000204514#ENST00000435989#C2H2 ZF Containing Proteins#KRAB$#ENSP00000469704#ENSG00000204514#ENST00000595295#C2H2 ZF Containing Proteins#$#ENSP00000469641#ENSG00000204514#ENST00000597807#C2H2 ZF Containing Proteins#KRAB$#ENSP00000469912#ENSG00000204514#ENST00000597832#C2H2 ZF Containing Proteins#KRAB$#ENSP00000470296#ENSG00000204514#ENST00000597342#C2H2 ZF Containing Proteins#KRAB TRUE 931 ENSG00000180257 ZNF816 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 125893 zinc finger protein 816 [Source:HGNC Symbol;Acc:HGNC:26995] None Full not tested None None c Yes No Yes 1a1, Direct HQ evidence Sam Lambert Arttu Jolma Yes $#ENSG00000180257#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000350295#ENSG00000180257#ENST00000357666#C2H2 ZF Containing Proteins#KRAB$#ENSP00000403266#ENSG00000180257#ENST00000444460#C2H2 ZF Containing Proteins#KRAB$#ENSP00000472475#ENSG00000180257#ENST00000270457#C2H2 ZF Containing Proteins#KRAB TRUE 932 ENSG00000102984 ZNF821 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR007087;IPR015880 55565 zinc finger protein 821 [Source:HGNC Symbol;Acc:HGNC:28043] None not tested not tested None None c Yes No Yes 1a1, Direct HQ evidence Arttu Jolma Jussi Taipale No $#ENSG00000102984#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000313822#ENSG00000102984#ENST00000313565#C2H2 ZF Containing Proteins#zf-C2H2_11, zf-C2H2_6, zf-met$#ENSP00000405908#ENSG00000102984#ENST00000446827#C2H2 ZF Containing Proteins#zf-C2H2_11, zf-C2H2_6, zf-met$#ENSP00000458112#ENSG00000102984#ENST00000562797#C2H2 ZF Containing Proteins#zf-C2H2_11, zf-met$#ENSP00000456193#ENSG00000102984#ENST00000565516#C2H2 ZF Containing Proteins#zf-C2H2_11, zf-met$#ENSP00000455648#ENSG00000102984#ENST00000565601#C2H2 ZF Containing Proteins#zf-C2H2_11, zf-C2H2_6, zf-met$#ENSP00000481362#ENSG00000102984#ENST00000611294#C2H2 ZF Containing Proteins# FALSE 933 ENSG00000197933 ZNF823 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 55552 zinc finger protein 823 [Source:HGNC Symbol;Acc:HGNC:30936] None DBD and Full not tested None None b Yes No No 1a1, Direct HQ evidence Jussi Taipale Pratyush Das Yes None $#ENSP00000340683#ENSG00000197933#ENST00000341191#C2H2 ZF Containing Proteins#KRAB$#ENSP00000410654#ENSG00000197933#ENST00000431998#C2H2 ZF Containing Proteins#$#ENSP00000387514#ENSG00000197933#ENST00000440527#C2H2 ZF Containing Proteins#KRAB$#ENSP00000466840#ENSG00000197933#ENST00000586121#C2H2 ZF Containing Proteins# TRUE 934 ENSG00000151612 ZNF827 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Has been shown to operate on telomeres and recruit the NuRD complex into them (PMID: 25150861). IPR007087;IPR015880 152485 zinc finger protein 827 [Source:HGNC Symbol;Acc:HGNC:27193] None Full not tested None None c Yes No No 4a, two or more datasets predict it as a TF Arttu Jolma Pratyush Das Yes None $#ENSP00000421863#ENSG00000151612#ENST00000508784#C2H2 ZF Containing Proteins#zf-H2C2_5$#ENSP00000423130#ENSG00000151612#ENST00000513320#C2H2 ZF Containing Proteins#SRP54_N, zf-C2H2_jaz, zf-H2C2_5$#ENSP00000368761#ENSG00000151612#ENST00000379448#C2H2 ZF Containing Proteins#zf-H2C2_5$#ENSP00000424456#ENSG00000151612#ENST00000511659#C2H2 ZF Containing Proteins#zf-H2C2_2, zf-H2C2_5 FALSE 935 ENSG00000185869 ZNF829 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR001909;IPR007087;IPR015880; 374899 zinc finger protein 829 [Source:HGNC Symbol;Acc:HGNC:34032] None Full not tested None None c Yes No Yes 4a, two or more datasets predict it as a TF Yimeng Yin Sam Lambert Yes $#ENSG00000185869#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000429266#ENSG00000185869#ENST00000391711#C2H2 ZF Containing Proteins#KRAB$#ENSP00000428679#ENSG00000185869#ENST00000520965#C2H2 ZF Containing Proteins#KRAB TRUE 936 ENSG00000167766 ZNF83 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains IPR001909;IPR007087;IPR015880; 55769 zinc finger protein 83 [Source:HGNC Symbol;Acc:HGNC:13158] None not tested not tested None None b Yes No Yes 4a, two or more datasets predict it as a TF Sam Lambert Arttu Jolma Yes $#ENSG00000167766#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000439681#ENSG00000167766#ENST00000541777#C2H2 ZF Containing Proteins#$#ENSP00000472619#ENSG00000167766#ENST00000597597#C2H2 ZF Containing Proteins#$#ENSP00000445993#ENSG00000167766#ENST00000536937#C2H2 ZF Containing Proteins#$#ENSP00000440713#ENSG00000167766#ENST00000545872#C2H2 ZF Containing Proteins#$#ENSP00000301096#ENSG00000167766#ENST00000301096#C2H2 ZF Containing Proteins#$#ENSP00000472392#ENSG00000167766#ENST00000600714#C2H2 ZF Containing Proteins#KRAB$#ENSP00000471703#ENSG00000167766#ENST00000601257#C2H2 ZF Containing Proteins#KRAB FALSE 937 ENSG00000198783 ZNF830 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif Single C2H2 domain Possible false positive. The C2H2 domain is a weak match, and doesnt come up on SMART or PFAM. Mouse ortholog is involved in DNA replication and repair (PMID: 25168238; PMID: 21191184). IPR003604; 91603 zinc finger protein 830 [Source:HGNC Symbol;Acc:HGNC:28291] None DBD and Full not tested None None b No No No 5a, one of the source datasets predicts is as a TF Sam Lambert Laura Campitelli No None $#ENSP00000354518#ENSG00000198783#ENST00000361952#Other#zf-C2H2_jaz, zf-met FALSE 938 ENSG00000124203 ZNF831 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR007087;IPR015880 128611 zinc finger protein 831 [Source:HGNC Symbol;Acc:HGNC:16167] None not tested not tested None None c Yes No Yes 4a, two or more datasets predict it as a TF Tim Hughes Jussi Taipale No $#ENSG00000124203#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000360069#ENSG00000124203#ENST00000371030#C2H2 ZF Containing Proteins#$#ENSP00000490240#ENSG00000124203#ENST00000637017#C2H2 ZF Containing Proteins# FALSE 939 ENSG00000127903 ZNF835 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains IPR007087;IPR015880 90485 zinc finger protein 835 [Source:HGNC Symbol;Acc:HGNC:34332] None not tested not tested None None c Yes No Yes 4a, two or more datasets predict it as a TF Pratyush Das Arttu Jolma Yes $#ENSG00000127903#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000444747#ENSG00000127903#ENST00000537055#C2H2 ZF Containing Proteins#$#ENSP00000470133#ENSG00000127903#ENST00000601659#C2H2 ZF Containing Proteins# FALSE 940 ENSG00000196267 ZNF836 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains and a KRAB-domain IPR001909;IPR007087;IPR015880; 162962 zinc finger protein 836 [Source:HGNC Symbol;Acc:HGNC:34333] None not tested not tested None None c Yes No Yes 4a, two or more datasets predict it as a TF Arttu Jolma Laura Campitelli Yes $#ENSG00000196267#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000472008#ENSG00000196267#ENST00000597065#C2H2 ZF Containing Proteins#KRAB$#ENSP00000470239#ENSG00000196267#ENST00000597252#C2H2 ZF Containing Proteins#KRAB$#ENSP00000325038#ENSG00000196267#ENST00000322146#C2H2 ZF Containing Proteins#KRAB$#ENSP00000470043#ENSG00000196267#ENST00000596428#C2H2 ZF Containing Proteins#KRAB TRUE 941 ENSG00000152475 ZNF837 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Has a nice cassette of znfC2H2 domains; virtually nothing is known about it otherwise. IPR007087;IPR015880 116412 zinc finger protein 837 [Source:HGNC Symbol;Acc:HGNC:25164] None Full not tested None None c Yes No Yes 4a, two or more datasets predict it as a TF Arttu Jolma Pratyush Das Yes $#ENSG00000152475#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000405699#ENSG00000152475#ENST00000427624#C2H2 ZF Containing Proteins#Zn-ribbon_8$#ENSP00000471478#ENSG00000152475#ENST00000597582#C2H2 ZF Containing Proteins#Zn-ribbon_8 FALSE 942 ENSG00000022976 ZNF839 C2H2 ZF No Unlikely to be sequence specific TF Not a DNA binding protein No motif None The single C2H2 domain has an insertion between the Hs. Also; it is embedded within the DUF4764 domain; which encompasses most of the protein. Its not located in the usual C2H2 loci. IPR007087; 55778 zinc finger protein 839 [Source:HGNC Symbol;Acc:HGNC:20345] None DBD not tested None None b No No No 5a, one of the source datasets predicts is as a TF Tim Hughes Pratyush Das No None $#ENSP00000452819#ENSG00000022976#ENST00000558490#C2H2 ZF Containing Proteins#DUF4764$#ENSP00000453363#ENSG00000022976#ENST00000558850#C2H2 ZF Containing Proteins#DUF4764$#ENSP00000453415#ENSG00000022976#ENST00000559155#C2H2 ZF Containing Proteins#DUF4764$#ENSP00000453109#ENSG00000022976#ENST00000559185#C2H2 ZF Containing Proteins#DUF4764$#ENSP00000453137#ENSG00000022976#ENST00000561251#C2H2 ZF Containing Proteins#DUF4764$#ENSP00000454159#ENSG00000022976#ENST00000558462#C2H2 ZF Containing Proteins#DUF4764$#ENSP00000453744#ENSG00000022976#ENST00000560112#C2H2 ZF Containing Proteins#DUF4764$#ENSP00000452983#ENSG00000022976#ENST00000560568#C2H2 ZF Containing Proteins#DUF4764 FALSE 943 ENSG00000198040 ZNF84 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 7637 zinc finger protein 84 [Source:HGNC Symbol;Acc:HGNC:13159] None Full not tested None None b Yes No No 1a1, Direct HQ evidence Yimeng Yin Arttu Jolma Yes None $#ENSP00000331465#ENSG00000198040#ENST00000327668#C2H2 ZF Containing Proteins#KRAB$#ENSP00000376133#ENSG00000198040#ENST00000392319#C2H2 ZF Containing Proteins#KRAB$#ENSP00000445549#ENSG00000198040#ENST00000539354#C2H2 ZF Containing Proteins#KRAB$#ENSP00000445820#ENSG00000198040#ENST00000540031#C2H2 ZF Containing Proteins#KRAB$#ENSP00000387416#ENSG00000198040#ENST00000438628#C2H2 ZF Containing Proteins#KRAB$#ENSP00000437636#ENSG00000198040#ENST00000545299#C2H2 ZF Containing Proteins# TRUE 944 ENSG00000197608 ZNF841 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains and a KRAB-domain IPR001909;IPR007087;IPR015880; 284371 zinc finger protein 841 [Source:HGNC Symbol;Acc:HGNC:27611] None not tested not tested None None c Yes No Yes 4a, two or more datasets predict it as a TF Arttu Jolma Laura Campitelli Yes $#ENSG00000197608#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000374185#ENSG00000197608#ENST00000389534#C2H2 ZF Containing Proteins#KRAB$#ENSP00000415453#ENSG00000197608#ENST00000426391#C2H2 ZF Containing Proteins#$#ENSP00000470746#ENSG00000197608#ENST00000594295#C2H2 ZF Containing Proteins#KRAB$#ENSP00000470100#ENSG00000197608#ENST00000594440#C2H2 ZF Containing Proteins#KRAB FALSE 945 ENSG00000176723 ZNF843 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif Single C2H2 domain None IPR007087; 283933 zinc finger protein 843 [Source:HGNC Symbol;Acc:HGNC:28710] None not tested not tested None None c Yes No No 4a, two or more datasets predict it as a TF Jussi Taipale Yimeng Yin No None $#ENSP00000483573#ENSG00000176723#ENST00000618063#C2H2 ZF Containing Proteins#$#ENSP00000322899#ENSG00000176723#ENST00000315678#C2H2 ZF Containing Proteins#$#ENSP00000455858#ENSG00000176723#ENST00000564218#C2H2 ZF Containing Proteins# FALSE 946 ENSG00000223547 ZNF844 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains and a KRAB-domain IPR001909;IPR007087;IPR015880; 284391 zinc finger protein 844 [Source:HGNC Symbol;Acc:HGNC:25932] None not tested not tested None None No Yes No No 5a, one of the source datasets predicts is as a TF Pratyush Das Arttu Jolma Yes None $#ENSP00000392024#ENSG00000223547#ENST00000439326#C2H2 ZF Containing Proteins#KRAB, zf-C2H2_4$#ENSP00000402097#ENSG00000223547#ENST00000441304#C2H2 ZF Containing Proteins#KRAB$#ENSP00000448588#ENSG00000223547#ENST00000550826#C2H2 ZF Containing Proteins#zf-C2H2_4 TRUE 947 ENSG00000213799 ZNF845 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains and a KRAB-domain IPR001909;IPR007087;IPR015880; 91664 Zinc finger protein 845 [Source:HGNC Symbol;Acc:HGNC:25112] None not tested not tested None None c Yes No No 4a, two or more datasets predict it as a TF Sam Lambert Arttu Jolma Yes None $#ENSP00000388311#ENSG00000213799#ENST00000458035#C2H2 ZF Containing Proteins#KRAB$#ENSP00000470005#ENSG00000213799#ENST00000595091#C2H2 ZF Containing Proteins#KRAB$#ENSP00000472689#ENSG00000213799#ENST00000601857#C2H2 ZF Containing Proteins#KRAB TRUE 948 ENSG00000196605 ZNF846 C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect None IPR001909;IPR003656;IPR007087;IPR015880 162993 zinc finger protein 846 [Source:HGNC Symbol;Acc:HGNC:27260] None Full not tested None None c Yes No No 1a1, Direct HQ evidence Sam Lambert Arttu Jolma Yes None $#ENSP00000380999#ENSG00000196605#ENST00000397902#C2H2 ZF Containing Proteins#KRAB$#ENSP00000466236#ENSG00000196605#ENST00000586293#C2H2 ZF Containing Proteins#KRAB$#ENSP00000465467#ENSG00000196605#ENST00000588267#C2H2 ZF Containing Proteins#$#ENSP00000467891#ENSG00000196605#ENST00000592859#C2H2 ZF Containing Proteins# TRUE 949 ENSG00000105750 ZNF85 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 7639 zinc finger protein 85 [Source:HGNC Symbol;Acc:HGNC:13160] None DBD and Full not tested None None b Yes No Yes 1a1, Direct HQ evidence Laura Campitelli Yimeng Yin Yes $#ENSG00000105750#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:9839802 $#ENSP00000300540#ENSG00000105750#ENST00000300540#C2H2 ZF Containing Proteins#KRAB$#ENSP00000329793#ENSG00000105750#ENST00000328178#C2H2 ZF Containing Proteins#KRAB$#ENSP00000469496#ENSG00000105750#ENST00000596476#C2H2 ZF Containing Proteins#KRAB$#ENSP00000472145#ENSG00000105750#ENST00000596534#C2H2 ZF Containing Proteins#$#ENSP00000469673#ENSG00000105750#ENST00000595742#C2H2 ZF Containing Proteins#$#ENSP00000471588#ENSG00000105750#ENST00000599064#C2H2 ZF Containing Proteins#$#ENSP00000470347#ENSG00000105750#ENST00000601284#C2H2 ZF Containing Proteins#KRAB TRUE 950 ENSG00000267041 ZNF850 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR001909;IPR007087;IPR015880 342892 zinc finger protein 850 [Source:HGNC Symbol;Acc:HGNC:27994] None not tested not tested None None No Yes No No 5a, one of the source datasets predicts is as a TF Pratyush Das Sam Lambert No None $#ENSP00000464976#ENSG00000267041#ENST00000591344#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2$#ENSP00000483509#ENSG00000267041#ENST00000614887#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2$#ENSP00000465189#ENSG00000267041#ENST00000589390#C2H2 ZF Containing Proteins#KRAB TRUE 951 ENSG00000178917 ZNF852 C2H2 ZF Yes Inferred motif Monomer or homomultimer High-throughput in vitro None Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains and a KRAB-domain IPR001909;IPR007087;IPR015880; 285346 zinc finger protein 852 [Source:HGNC Symbol;Acc:HGNC:27713] None not tested not tested None None c Yes No No 4a, two or more datasets predict it as a TF Yimeng Yin Arttu Jolma No None $#ENSP00000389841#ENSG00000178917#ENST00000436261#C2H2 ZF Containing Proteins#KRAB TRUE 952 ENSG00000236609 ZNF853 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains IPR007087;IPR015880 54753 zinc finger protein 853 [Source:HGNC Symbol;Acc:HGNC:21767] None not tested not tested None None No Yes No No 5a, one of the source datasets predicts is as a TF Arttu Jolma Jussi Taipale Yes None $#ENSP00000455585#ENSG00000236609#ENST00000457543#C2H2 ZF Containing Proteins# FALSE 953 ENSG00000197385 ZNF860 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 344787 zinc finger protein 860 [Source:HGNC Symbol;Acc:HGNC:34513] None not tested not tested None None c Yes No No 1a1, Direct HQ evidence Arttu Jolma Yimeng Yin Yes None $#ENSP00000373274#ENSG00000197385#ENST00000360311#C2H2 ZF Containing Proteins#KRAB TRUE 954 ENSG00000261221 ZNF865 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR007087;IPR015880 100507290 zinc finger protein 865 [Source:HGNC Symbol;Acc:HGNC:38705] None not tested not tested None None No Yes No No 5a, one of the source datasets predicts is as a TF Jussi Taipale Sam Lambert No None $#ENSP00000457715#ENSG00000261221#ENST00000568956#C2H2 ZF Containing Proteins#$#ENSP00000487098#ENSG00000261221#ENST00000630143#C2H2 ZF Containing Proteins# FALSE 955 ENSG00000257446 ZNF878 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR001909;IPR007087;IPR015880; 729747 zinc finger protein 878 [Source:HGNC Symbol;Acc:HGNC:37246] None not tested not tested None None No Yes No No 5a, one of the source datasets predicts is as a TF Pratyush Das Laura Campitelli Yes None $#ENSP00000447931#ENSG00000257446#ENST00000547628#C2H2 ZF Containing Proteins#KRAB TRUE 956 ENSG00000234284 ZNF879 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 345462 zinc finger protein 879 [Source:HGNC Symbol;Acc:HGNC:37273] None not tested not tested None TFs that are in CisBP but not in Vaquerizas set No Yes No Yes 1a1, Direct HQ evidence Jussi Taipale Laura Campitelli Yes $#ENSG00000234284#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000414887#ENSG00000234284#ENST00000444149#C2H2 ZF Containing Proteins#KRAB$#ENSP00000430047#ENSG00000234284#ENST00000519896#C2H2 ZF Containing Proteins#$#ENSP00000428477#ENSG00000234284#ENST00000522442#C2H2 ZF Containing Proteins#KRAB$#ENSP00000431043#ENSG00000234284#ENST00000521285#C2H2 ZF Containing Proteins#KRAB TRUE 957 ENSG00000221923 ZNF880 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 400713 zinc finger protein 880 [Source:HGNC Symbol;Acc:HGNC:37249] None not tested not tested None TFs that are in CisBP but not in Vaquerizas set No Yes No Yes 1a1, Direct HQ evidence Yimeng Yin Jussi Taipale Yes $#ENSG00000221923#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000343625#ENSG00000221923#ENST00000344085#C2H2 ZF Containing Proteins#KRAB$#ENSP00000406318#ENSG00000221923#ENST00000422689#C2H2 ZF Containing Proteins#KRAB$#ENSP00000471324#ENSG00000221923#ENST00000597976#C2H2 ZF Containing Proteins#KRAB$#ENSP00000471067#ENSG00000221923#ENST00000600321#C2H2 ZF Containing Proteins#KRAB TRUE 958 ENSG00000228623 ZNF883 C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain None IPR007087; 169834 zinc finger protein 883 [Source:HGNC Symbol;Acc:HGNC:27271] None not tested not tested None None No Yes No Yes 2a1, Lower confidence direct evidence Sam Lambert Jussi Taipale Yes $#ENSG00000228623#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000490059#ENSG00000228623#ENST00000619044#C2H2 ZF Containing Proteins# FALSE 959 ENSG00000213793 ZNF888 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None One transcript is protein-coding None None Zinc finger protein 888 None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Sam Lambert Laura Campitelli No $#ENSG00000213793#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $##ENSG00000213793##Other# FALSE 960 ENSG00000214029 ZNF891 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 101060200 zinc finger protein 891 [Source:HGNC Symbol;Acc:HGNC:38709] None not tested not tested None None x Yes No No 1a1, Direct HQ evidence Arttu Jolma Laura Campitelli Yes None $#ENSP00000437590#ENSG00000214029#ENST00000537226#C2H2 ZF Containing Proteins#KRAB TRUE 961 ENSG00000213988 ZNF90 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR000754;IPR001909;IPR007087;IPR015880;IPR020568 7643 zinc finger protein 90 [Source:HGNC Symbol;Acc:HGNC:13165] None Full not tested None None No Yes No Yes 1a1, Direct HQ evidence Pratyush Das Laura Campitelli Yes $#ENSG00000213988#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:2023909 $#ENSP00000410466#ENSG00000213988#ENST00000418063#C2H2 ZF Containing Proteins#KRAB$#ENSP00000482310#ENSG00000213988#ENST00000434475#C2H2 ZF Containing Proteins#Ribosomal_S9 TRUE 962 ENSG00000167232 ZNF91 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR001909;IPR007087;IPR015880; 7644 zinc finger protein 91 [Source:HGNC Symbol;Acc:HGNC:13166] None not tested not tested None None a Yes No Yes 4a, two or more datasets predict it as a TF Sam Lambert Laura Campitelli Yes $#ENSG00000167232#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:25274305 | NAS - PMID:2023909 $#ENSP00000300619#ENSG00000167232#ENST00000300619#C2H2 ZF Containing Proteins#KRAB, zf-C2H2_jaz, zf-H2C2_2$#ENSP00000380272#ENSG00000167232#ENST00000397082#C2H2 ZF Containing Proteins#KRAB, zf-C2H2_jaz, zf-H2C2_2$#ENSP00000471709#ENSG00000167232#ENST00000595533#C2H2 ZF Containing Proteins#zf-H2C2_2$#ENSP00000468867#ENSG00000167232#ENST00000599743#C2H2 ZF Containing Proteins#KRAB TRUE 963 ENSG00000146757 ZNF92 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains and a KRAB-domain IPR001909;IPR007087;IPR015880; 168374 zinc finger protein 92 [Source:HGNC Symbol;Acc:HGNC:13168] None DBD and Full not tested None None b Yes No Yes 4a, two or more datasets predict it as a TF Sam Lambert Arttu Jolma Yes $#ENSG00000146757#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:2023909 $#ENSP00000332595#ENSG00000146757#ENST00000328747#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2$#ENSP00000350113#ENSG00000146757#ENST00000357512#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2$#ENSP00000400495#ENSG00000146757#ENST00000431504#C2H2 ZF Containing Proteins#zf-H2C2_2$#ENSP00000396126#ENSG00000146757#ENST00000450302#C2H2 ZF Containing Proteins#zf-H2C2_2 TRUE 964 ENSG00000184635 ZNF93 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) Kruppel family C2H2 ZF. IPR001909;IPR007087;IPR015880; 81931 zinc finger protein 93 [Source:HGNC Symbol;Acc:HGNC:13169] None not tested not tested None None b Yes No Yes 1a1, Direct HQ evidence Jussi Taipale Arttu Jolma Yes None $#ENSP00000342002#ENSG00000184635#ENST00000343769#C2H2 ZF Containing Proteins#KRAB$#ENSP00000467377#ENSG00000184635#ENST00000592160#C2H2 ZF Containing Proteins#KRAB$#ENSP00000467652#ENSG00000184635#ENST00000591366#C2H2 ZF Containing Proteins#KRAB$#ENSP00000467553#ENSG00000184635#ENST00000588146#C2H2 ZF Containing Proteins#zf-H2C2_2 TRUE 965 ENSG00000197360 ZNF98 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR001909;IPR007087;IPR015880; 148198 zinc finger protein 98 [Source:HGNC Symbol;Acc:HGNC:13174] None Full not tested None None c Yes No No 1a1, Direct HQ evidence Yimeng Yin Pratyush Das Yes None $#ENSP00000350418#ENSG00000197360#ENST00000357774#C2H2 ZF Containing Proteins#KRAB$#ENSP00000472301#ENSG00000197360#ENST00000593802#C2H2 ZF Containing Proteins#KRAB$#ENSP00000470558#ENSG00000197360#ENST00000601553#C2H2 ZF Containing Proteins#KRAB$#ENSP00000470736#ENSG00000197360#ENST00000593657#C2H2 ZF Containing Proteins#ISK_Channel, KRAB TRUE 966 ENSG00000213973 ZNF99 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR001909;IPR007087;IPR015880; 7652 zinc finger protein 99 [Source:HGNC Symbol;Acc:HGNC:13175] None not tested not tested None None b Yes No No 4a, two or more datasets predict it as a TF Yimeng Yin Jussi Taipale Yes None $#ENSP00000380293#ENSG00000213973#ENST00000397104#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2$#ENSP00000472969#ENSG00000213973#ENST00000596209#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2 TRUE 967 ENSG00000152467 ZSCAN1 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR003309;IPR007087;IPR008916;IPR015880 284312 zinc finger and SCAN domain containing 1 [Source:HGNC Symbol;Acc:HGNC:23712] None DBD and Full not tested None None b Yes No Yes 1a1, Direct HQ evidence Yimeng Yin Arttu Jolma Yes $#ENSG00000152467#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000375581#ENSG00000152467#ENST00000391700#C2H2 ZF Containing Proteins#SCAN$#ENSP00000470438#ENSG00000152467#ENST00000601162#C2H2 ZF Containing Proteins#SCAN$#ENSP00000282326#ENSG00000152467#ENST00000282326#C2H2 ZF Containing Proteins#SCAN FALSE 968 ENSG00000130182 ZSCAN10 C2H2 ZF Yes Inferred motif Monomer or homomultimer High-throughput in vitro None None IPR003309;IPR007087;IPR008916;IPR015880 84891 zinc finger and SCAN domain containing 10 [Source:HGNC Symbol;Acc:HGNC:12997] None not tested Yes None None b Yes No Yes 1a1, Direct HQ evidence Pratyush Das Arttu Jolma Yes $#ENSG00000130182#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 | ISS - GO_REF:0000024 $#ENSP00000252463#ENSG00000130182#ENST00000252463#C2H2 ZF Containing Proteins#SCAN$#ENSP00000459520#ENSG00000130182#ENST00000575108#C2H2 ZF Containing Proteins#$#ENSP00000460473#ENSG00000130182#ENST00000572431#C2H2 ZF Containing Proteins#$#ENSP00000461871#ENSG00000130182#ENST00000572548#C2H2 ZF Containing Proteins#SCAN$#ENSP00000458260#ENSG00000130182#ENST00000576483#C2H2 ZF Containing Proteins#SCAN FALSE 969 ENSG00000158691 ZSCAN12 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains and a SCAN-domain IPR003309;IPR007087;IPR008916;IPR015880 9753 zinc finger and SCAN domain containing 12 [Source:HGNC Symbol;Acc:HGNC:13172] None DBD and Full not tested None None b Yes No Yes 4a, two or more datasets predict it as a TF Sam Lambert Arttu Jolma Yes $#ENSG00000158691#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000354305#ENSG00000158691#ENST00000361028#C2H2 ZF Containing Proteins#SCAN$#ENSP00000380039#ENSG00000158691#ENST00000396827#C2H2 ZF Containing Proteins#SCAN FALSE 970 ENSG00000196812 ZSCAN16 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR003309;IPR007087;IPR008916;IPR015880 80345 zinc finger and SCAN domain containing 16 [Source:HGNC Symbol;Acc:HGNC:20813] None DBD and Full not tested None There is also a model in the Cell2013 paper but it has outdated symbol ZNF435 b Yes No Yes 1a1, Direct HQ evidence Pratyush Das Yimeng Yin Yes $#ENSG00000196812#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000366527#ENSG00000196812#ENST00000340487#C2H2 ZF Containing Proteins#SCAN FALSE 971 ENSG00000121413 ZSCAN18 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR003309;IPR007087;IPR008916;IPR015880 65982 zinc finger and SCAN domain containing 18 [Source:HGNC Symbol;Acc:HGNC:21037] None DBD not tested None None b Yes No Yes 4a, two or more datasets predict it as a TF Sam Lambert Tim Hughes No $#ENSG00000121413#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000240727#ENSG00000121413#ENST00000240727#C2H2 ZF Containing Proteins#SCAN$#ENSP00000412253#ENSG00000121413#ENST00000433686#C2H2 ZF Containing Proteins#$#ENSP00000468934#ENSG00000121413#ENST00000601144#C2H2 ZF Containing Proteins#SCAN$#ENSP00000471570#ENSG00000121413#ENST00000595944#C2H2 ZF Containing Proteins#$#ENSP00000470123#ENSG00000121413#ENST00000600404#C2H2 ZF Containing Proteins#SCAN$#ENSP00000472129#ENSG00000121413#ENST00000600845#C2H2 ZF Containing Proteins#SCAN$#ENSP00000470329#ENSG00000121413#ENST00000600522#C2H2 ZF Containing Proteins#$#ENSP00000473019#ENSG00000121413#ENST00000600897#C2H2 ZF Containing Proteins#SCAN FALSE 972 ENSG00000176371 ZSCAN2 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains and a SCAN-domain IPR003309;IPR007087;IPR008916;IPR015880 54993 zinc finger and SCAN domain containing 2 [Source:HGNC Symbol;Acc:HGNC:20994] None Full not tested None None a Yes No Yes 4a, two or more datasets predict it as a TF Pratyush Das Arttu Jolma Yes $#ENSG00000176371#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000325123#ENSG00000176371#ENST00000327179#C2H2 ZF Containing Proteins#SCAN$#ENSP00000333895#ENSG00000176371#ENST00000334141#C2H2 ZF Containing Proteins#SCAN$#ENSP00000368663#ENSG00000176371#ENST00000379358#C2H2 ZF Containing Proteins#SCAN$#ENSP00000440004#ENSG00000176371#ENST00000485222#C2H2 ZF Containing Proteins#SCAN$#ENSP00000439132#ENSG00000176371#ENST00000538076#C2H2 ZF Containing Proteins#SCAN$#ENSP00000441342#ENSG00000176371#ENST00000541040#C2H2 ZF Containing Proteins#SCAN$#ENSP00000351257#ENSG00000176371#ENST00000358472#C2H2 ZF Containing Proteins#$#ENSP00000445451#ENSG00000176371#ENST00000546148#C2H2 ZF Containing Proteins#SCAN FALSE 973 ENSG00000121903 ZSCAN20 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR001005;IPR003309;IPR007087;IPR008916;IPR015880; 7579 zinc finger and SCAN domain containing 20 [Source:HGNC Symbol;Acc:HGNC:13093] None Full Yes None None b Yes No Yes 1a1, Direct HQ evidence Pratyush Das Sam Lambert Yes $#ENSG00000121903#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000362512#ENSG00000121903#ENST00000373413#C2H2 ZF Containing Proteins#Myb_DNA-bind_4, SCAN$#ENSP00000355053#ENSG00000121903#ENST00000361328#C2H2 ZF Containing Proteins#SCAN FALSE 974 ENSG00000166529 ZSCAN21 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Binds AGYACNNNNNNNGGYAC consensus based on SELEX (PMID: 8625807). IPR003309;IPR007087;IPR008916;IPR015880 7589 zinc finger and SCAN domain containing 21 [Source:HGNC Symbol;Acc:HGNC:13104] None Full not tested None None b Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:8625807;10431235 Yes 4a, two or more datasets predict it as a TF Arttu Jolma Jussi Taipale Yes $#ENSG00000166529#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:19549071 $#ENSP00000292450#ENSG00000166529#ENST00000292450#C2H2 ZF Containing Proteins#SCAN$#ENSP00000404207#ENSG00000166529#ENST00000438937#C2H2 ZF Containing Proteins#SCAN$#ENSP00000441212#ENSG00000166529#ENST00000543588#C2H2 ZF Containing Proteins#SCAN$#ENSP00000390960#ENSG00000166529#ENST00000456748#C2H2 ZF Containing Proteins#SCAN FALSE 975 ENSG00000182318 ZSCAN22 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR003309;IPR007087;IPR008916;IPR015880 342945 zinc finger and SCAN domain containing 22 [Source:HGNC Symbol;Acc:HGNC:4929] None DBD and Full not tested None None b Yes No Yes 1a1, Direct HQ evidence Sam Lambert Yimeng Yin Yes $#ENSG00000182318#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000332433#ENSG00000182318#ENST00000329665#C2H2 ZF Containing Proteins#SCAN FALSE 976 ENSG00000187987 ZSCAN23 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR003309;IPR007087;IPR008916;IPR015880 222696 zinc finger and SCAN domain containing 23 [Source:HGNC Symbol;Acc:HGNC:21193] None DBD not tested None None b Yes No Yes 1a1, Direct HQ evidence Laura Campitelli Yimeng Yin Yes $#ENSG00000187987#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000289788#ENSG00000187987#ENST00000289788#C2H2 ZF Containing Proteins#SCAN FALSE 977 ENSG00000197037 ZSCAN25 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains and a SCAN-domain IPR003309;IPR007087;IPR008916;IPR015880 221785 zinc finger and SCAN domain containing 25 [Source:HGNC Symbol;Acc:HGNC:21961] None DBD and Full not tested None None b Yes No Yes 4a, two or more datasets predict it as a TF Jussi Taipale Arttu Jolma Yes $#ENSG00000197037#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000262941#ENSG00000197037#ENST00000262941#C2H2 ZF Containing Proteins#SCAN$#ENSP00000334800#ENSG00000197037#ENST00000334715#C2H2 ZF Containing Proteins#KRAB, SCAN$#ENSP00000413144#ENSG00000197037#ENST00000431485#C2H2 ZF Containing Proteins#SCAN$#ENSP00000377708#ENSG00000197037#ENST00000394152#C2H2 ZF Containing Proteins#KRAB, SCAN FALSE 978 ENSG00000197062 ZSCAN26 C2H2 ZF Yes Known motif Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain None IPR003309;IPR007087;IPR008916;IPR015880 7741 zinc finger and SCAN domain containing 26 [Source:HGNC Symbol;Acc:HGNC:12978] None DBD and Full not tested None None b Yes No Yes 1a1, Direct HQ evidence Sam Lambert Jussi Taipale Yes $#ENSG00000197062#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 | NAS - PMID:1569959 $#ENSP00000484931#ENSG00000197062#ENST00000316606#C2H2 ZF Containing Proteins#$#ENSP00000481707#ENSG00000197062#ENST00000421553#C2H2 ZF Containing Proteins#SCAN$#ENSP00000478769#ENSG00000197062#ENST00000611552#C2H2 ZF Containing Proteins#$#ENSP00000481024#ENSG00000197062#ENST00000617168#C2H2 ZF Containing Proteins#SCAN$#ENSP00000484018#ENSG00000197062#ENST00000619937#C2H2 ZF Containing Proteins#SCAN$#ENSP00000479314#ENSG00000197062#ENST00000614088#C2H2 ZF Containing Proteins#$#ENSP00000485228#ENSG00000197062#ENST00000623276#C2H2 ZF Containing Proteins#SCAN FALSE 979 ENSG00000140265 ZSCAN29 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro Has a putative AT-hook None IPR003309;IPR007087;IPR008916;IPR015880 146050 zinc finger and SCAN domain containing 29 [Source:HGNC Symbol;Acc:HGNC:26673] None DBD and Full Yes None None b Yes No Yes 1a1, Direct HQ evidence Sam Lambert Yimeng Yin Yes $#ENSG00000140265#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000380174#ENSG00000140265#ENST00000396976#C2H2 ZF Containing Proteins#SCAN$#ENSP00000456089#ENSG00000140265#ENST00000562072#C2H2 ZF Containing Proteins#SCAN$#ENSP00000456883#ENSG00000140265#ENST00000568898#C2H2 ZF Containing Proteins#SCAN$#ENSP00000454548#ENSG00000140265#ENST00000570181#C2H2 ZF Containing Proteins#Myb_DNA-bind_4, SCAN$#ENSP00000458119#ENSG00000140265#ENST00000561661#C2H2 ZF Containing Proteins# FALSE 980 ENSG00000186814 ZSCAN30 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR003309;IPR007087;IPR008916;IPR015880 100101467 zinc finger and SCAN domain containing 30 [Source:HGNC Symbol;Acc:HGNC:33517] None not tested not tested None None c Yes No Yes 1a1, Direct HQ evidence Yimeng Yin Laura Campitelli Yes $#ENSG00000186814#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000329738#ENSG00000186814#ENST00000333206#C2H2 ZF Containing Proteins#SCAN$#ENSP00000392371#ENSG00000186814#ENST00000420878#C2H2 ZF Containing Proteins#SCAN$#ENSP00000470677#ENSG00000186814#ENST00000588448#C2H2 ZF Containing Proteins#SCAN$#ENSP00000465046#ENSG00000186814#ENST00000589178#C2H2 ZF Containing Proteins#SCAN$#ENSP00000468180#ENSG00000186814#ENST00000592598#C2H2 ZF Containing Proteins#SCAN FALSE 981 ENSG00000235109 ZSCAN31 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) Also known as ZNF323 IPR003309;IPR007087;IPR008916;IPR015880 64288 zinc finger and SCAN domain containing 31 [Source:HGNC Symbol;Acc:HGNC:14097] None Full not tested None Vaquerizas paper and the Methylpaper are using old symbol ZNF323 b Yes No No 1a1, Direct HQ evidence Sam Lambert Arttu Jolma Yes $#ENSG00000235109#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000345339#ENSG00000235109#ENST00000344279#C2H2 ZF Containing Proteins#SCAN$#ENSP00000380050#ENSG00000235109#ENST00000396838#C2H2 ZF Containing Proteins#SCAN$#ENSP00000413705#ENSG00000235109#ENST00000439158#C2H2 ZF Containing Proteins#SCAN$#ENSP00000402937#ENSG00000235109#ENST00000446474#C2H2 ZF Containing Proteins#$#ENSP00000390076#ENSG00000235109#ENST00000414429#C2H2 ZF Containing Proteins#SCAN$#ENSP00000391235#ENSG00000235109#ENST00000435857#C2H2 ZF Containing Proteins#$#ENSP00000416225#ENSG00000235109#ENST00000434036#C2H2 ZF Containing Proteins#SCAN$#ENSP00000412519#ENSG00000235109#ENST00000439636#C2H2 ZF Containing Proteins#SCAN$#ENSP00000411033#ENSG00000235109#ENST00000446222#C2H2 ZF Containing Proteins#SCAN$#ENSP00000416108#ENSG00000235109#ENST00000447021#C2H2 ZF Containing Proteins#SCAN$#ENSP00000389479#ENSG00000235109#ENST00000453745#C2H2 ZF Containing Proteins#SCAN FALSE 982 ENSG00000140987 ZSCAN32 C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR003309;IPR007087;IPR008916;IPR015880 54925 zinc finger and SCAN domain containing 32 [Source:HGNC Symbol;Acc:HGNC:20812] None Full not tested None None b Yes No Yes 4a, two or more datasets predict it as a TF Pratyush Das Arttu Jolma Yes $#ENSG00000140987#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000302502#ENSG00000140987#ENST00000304926#C2H2 ZF Containing Proteins#KRAB, Myb_DNA-bind_4$#ENSP00000380057#ENSG00000140987#ENST00000396846#C2H2 ZF Containing Proteins#KRAB, Myb_DNA-bind_4, SCAN$#ENSP00000380061#ENSG00000140987#ENST00000396852#C2H2 ZF Containing Proteins#KRAB, Myb_DNA-bind_4, SCAN$#ENSP00000460487#ENSG00000140987#ENST00000573327#C2H2 ZF Containing Proteins#KRAB, Myb_DNA-bind_4, SCAN$#ENSP00000407312#ENSG00000140987#ENST00000422427#C2H2 ZF Containing Proteins#KRAB, Myb_DNA-bind_4$#ENSP00000391787#ENSG00000140987#ENST00000439568#C2H2 ZF Containing Proteins#Myb_DNA-bind_4$#ENSP00000459772#ENSG00000140987#ENST00000574940#C2H2 ZF Containing Proteins#KRAB, Myb_DNA-bind_4, SCAN$#ENSP00000483210#ENSG00000140987#ENST00000618425#C2H2 ZF Containing Proteins#Myb_DNA-bind_4$#ENSP00000460833#ENSG00000140987#ENST00000573719#C2H2 ZF Containing Proteins#SCAN$#ENSP00000459960#ENSG00000140987#ENST00000573830#C2H2 ZF Containing Proteins#Myb_DNA-bind_4$#ENSP00000458899#ENSG00000140987#ENST00000575350#C2H2 ZF Containing Proteins#KRAB, Myb_DNA-bind_4 TRUE 983 ENSG00000180532 ZSCAN4 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR003309;IPR007087;IPR008916;IPR015880 201516 zinc finger and SCAN domain containing 4 [Source:HGNC Symbol;Acc:HGNC:23709] None DBD and Full Yes None None b Yes No Yes 1a1, Direct HQ evidence Sam Lambert Pratyush Das Yes $#ENSG00000180532#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000321963#ENSG00000180532#ENST00000318203#C2H2 ZF Containing Proteins#SCAN$#ENSP00000480210#ENSG00000180532#ENST00000612521#C2H2 ZF Containing Proteins#SCAN FALSE 984 ENSG00000131848 ZSCAN5A C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR003309;IPR007087;IPR008916;IPR015880 79149 zinc finger and SCAN domain containing 5A [Source:HGNC Symbol;Acc:HGNC:23710] None DBD and Full not tested None MethylPaper_Yin2016 PWM has outdated symbol ZSCAN5 b Yes No Yes 1a1, Direct HQ evidence Arttu Jolma Pratyush Das Yes $#ENSG00000131848#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000375593#ENSG00000131848#ENST00000391713#C2H2 ZF Containing Proteins#SCAN$#ENSP00000467631#ENSG00000131848#ENST00000587340#C2H2 ZF Containing Proteins#SCAN$#ENSP00000466445#ENSG00000131848#ENST00000587492#C2H2 ZF Containing Proteins#$#ENSP00000467238#ENSG00000131848#ENST00000592355#C2H2 ZF Containing Proteins#SCAN$#ENSP00000468797#ENSG00000131848#ENST00000592509#C2H2 ZF Containing Proteins#SCAN$#ENSP00000466830#ENSG00000131848#ENST00000592679#C2H2 ZF Containing Proteins# FALSE 985 ENSG00000197213 ZSCAN5B C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR003309;IPR007087;IPR008916;IPR015880 342933 zinc finger and SCAN domain containing 5B [Source:HGNC Symbol;Acc:HGNC:34246] None not tested not tested None None c Yes No Yes 4a, two or more datasets predict it as a TF Laura Campitelli Jussi Taipale Yes $#ENSG00000197213#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000351883#ENSG00000197213#ENST00000358992#C2H2 ZF Containing Proteins#SCAN$#ENSP00000466072#ENSG00000197213#ENST00000586855#C2H2 ZF Containing Proteins#SCAN$#ENSP00000468660#ENSG00000197213#ENST00000587032#C2H2 ZF Containing Proteins#SCAN$#ENSP00000465118#ENSG00000197213#ENST00000589938#C2H2 ZF Containing Proteins#SCAN FALSE 986 ENSG00000204532 ZSCAN5C C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None IPR003309;IPR007087;IPR008916;IPR015880 None zinc finger and SCAN domain containing 5C, pseudogene [Source:HGNC Symbol;Acc:HGNC:34294] None not tested not tested None None c Yes No Yes 1a1, Direct HQ evidence Jussi Taipale Laura Campitelli Yes $#ENSG00000204532#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000365443#ENSG00000204532#ENST00000376267#C2H2 ZF Containing Proteins#SCAN$#ENSP00000435234#ENSG00000204532#ENST00000534327#C2H2 ZF Containing Proteins#SCAN FALSE 987 ENSG00000267908 ZSCAN5DP C2H2 ZF No Unlikely to be sequence specific TF Not a DNA binding protein No motif Pseudogene None None None Putative zinc finger and SCAN domain-containing protein 5D None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Pratyush Das Arttu Jolma No $#ENSG00000267908#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033 $##ENSG00000267908##Other# FALSE 988 ENSG00000137185 ZSCAN9 C2H2 ZF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR003309;IPR007087;IPR008916;IPR015880 7746 zinc finger and SCAN domain containing 9 [Source:HGNC Symbol;Acc:HGNC:12984] None DBD and Full not tested None None b Yes No Yes 1a1, Direct HQ evidence Sam Lambert Jussi Taipale Yes $#ENSG00000137185#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000252207#ENSG00000137185#ENST00000252207#C2H2 ZF Containing Proteins#SCAN$#ENSP00000404074#ENSG00000137185#ENST00000425468#C2H2 ZF Containing Proteins#SCAN$#ENSP00000476254#ENSG00000137185#ENST00000526391#C2H2 ZF Containing Proteins#SCAN$#ENSP00000433468#ENSG00000137185#ENST00000527436#C2H2 ZF Containing Proteins#SCAN$#ENSP00000433402#ENSG00000137185#ENST00000531979#C2H2 ZF Containing Proteins#SCAN FALSE 989 ENSG00000153975 ZUFSP C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR007087;IPR012462;IPR015880; 221302 zinc finger with UFM1 specific peptidase domain [Source:HGNC Symbol;Acc:HGNC:21224] None not tested Yes None None c Yes No No 4a, two or more datasets predict it as a TF Laura Campitelli Pratyush Das No None $#ENSP00000357565#ENSG00000153975#ENST00000368576#C2H2 ZF Containing Proteins#Peptidase_C54, Peptidase_C78, zf-C2H2_4, zf-Di19$#ENSP00000357562#ENSG00000153975#ENST00000368573#C2H2 ZF Containing Proteins#zf-Di19 FALSE 990 ENSG00000198205 ZXDA C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Complexes with CIITA and the similar protein ZXDC to regulate MHCII complex transcription (PMID: 17493635). IPR007087;IPR015880 7789 zinc finger, X-linked, duplicated A [Source:HGNC Symbol;Acc:HGNC:13198] None not tested not tested None None b Yes No Yes 4a, two or more datasets predict it as a TF Yimeng Yin Arttu Jolma Yes $#ENSG00000198205#GO:0003700#sequence-specific DNA binding transcription factor activity#IMP - PMID:17493635 $#ENSP00000351530#ENSG00000198205#ENST00000358697#C2H2 ZF Containing Proteins# FALSE 991 ENSG00000198455 ZXDB C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR007087;IPR015880 158586 zinc finger, X-linked, duplicated B [Source:HGNC Symbol;Acc:HGNC:13199] None not tested not tested None None b Yes No No 4a, two or more datasets predict it as a TF Jussi Taipale Pratyush Das Yes None $#ENSP00000364023#ENSG00000198455#ENST00000374888#C2H2 ZF Containing Proteins# FALSE 992 ENSG00000070476 ZXDC C2H2 ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR007087;IPR015880 79364 ZXD family zinc finger C [Source:HGNC Symbol;Acc:HGNC:28160] None Full Yes None None b Yes No Yes 4a, two or more datasets predict it as a TF Jussi Taipale Laura Campitelli Yes $#ENSG00000070476#GO:0003700#sequence-specific DNA binding transcription factor activity#IMP - PMID:17493635 $#ENSP00000337694#ENSG00000070476#ENST00000336332#C2H2 ZF Containing Proteins#zf-C2H2_4$#ENSP00000374359#ENSG00000070476#ENST00000389709#C2H2 ZF Containing Proteins#zf-C2H2_4 FALSE 993 ENSG00000100105 PATZ1 C2H2 ZF; AT hook Yes Known motif Monomer or homomultimer In vivo/Misc source Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect None IPR000210;IPR000637;IPR007087;IPR011333;IPR013069;IPR015880 23598 POZ/BTB and AT hook containing zinc finger 1 [Source:HGNC Symbol;Acc:HGNC:13071] None Full not tested None None b Yes TF Gene_Transcription Factor Binding: tf co-factor binding; DNA-Binding: sequence-specific_Co-activation_PMIDS:10669750 No 1a1, Direct HQ evidence Laura Campitelli Yimeng Yin Yes None $#ENSP00000215919#ENSG00000100105#ENST00000215919#C2H2 ZF Containing Proteins#BTB$#ENSP00000266269#ENSG00000100105#ENST00000266269#C2H2 ZF Containing Proteins#BTB, zf-C2H2_4, zf-C2H2_assoc3$#ENSP00000337520#ENSG00000100105#ENST00000351933#C2H2 ZF Containing Proteins#BTB, zf-C2H2_4, zf-C2H2_assoc3, zf-Di19$#ENSP00000384173#ENSG00000100105#ENST00000405309#C2H2 ZF Containing Proteins#BTB, zf-C2H2_4, zf-Di19 FALSE 994 ENSG00000112365 ZBTB24 C2H2 ZF; AT hook Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR000210;IPR007087;IPR011333;IPR013069;IPR015880; 9841 zinc finger and BTB domain containing 24 [Source:HGNC Symbol;Acc:HGNC:21143] None Full not tested None None b Yes No No 4a, two or more datasets predict it as a TF Sam Lambert Pratyush Das Yes None $#ENSP00000230122#ENSG00000112365#ENST00000230122#C2H2 ZF Containing Proteins#BTB FALSE 995 ENSG00000171443 ZNF524 C2H2 ZF; AT hook Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR007087;IPR015880 147807 zinc finger protein 524 [Source:HGNC Symbol;Acc:HGNC:28322] None DBD and Full not tested None None b Yes No No 1a1, Direct HQ evidence Pratyush Das Jussi Taipale Yes None $#ENSP00000301073#ENSG00000171443#ENST00000301073#C2H2 ZF Containing Proteins#$#ENSP00000467175#ENSG00000171443#ENST00000589521#C2H2 ZF Containing Proteins#$#ENSP00000466907#ENSG00000171443#ENST00000591046#C2H2 ZF Containing Proteins# FALSE 996 ENSG00000161914 ZNF653 C2H2 ZF; AT hook Yes Known motif Monomer or homomultimer In vivo/Misc source None None IPR007087;IPR015880 115950 zinc finger protein 653 [Source:HGNC Symbol;Acc:HGNC:25196] None DBD and Full not tested None None b Yes No No 1a1, Direct HQ evidence Jussi Taipale Arttu Jolma Yes None $#ENSP00000293771#ENSG00000161914#ENST00000293771#C2H2 ZF Containing Proteins#$#ENSP00000465166#ENSG00000161914#ENST00000590296#C2H2 ZF Containing Proteins#$#ENSP00000467069#ENSG00000161914#ENST00000592756#C2H2 ZF Containing Proteins#$#ENSP00000465955#ENSG00000161914#ENST00000589051#C2H2 ZF Containing Proteins# FALSE 997 ENSG00000198839 ZNF277 C2H2 ZF; BED ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Virtually nothing is known for this protein except that it has a some znfC2H2 and znfBED domains IPR007087;IPR015880 11179 zinc finger protein 277 [Source:HGNC Symbol;Acc:HGNC:13070] None Full not tested None None b Yes No No 4a, two or more datasets predict it as a TF Sam Lambert Arttu Jolma Yes None $#ENSP00000354501#ENSG00000198839#ENST00000361822#C2H2 ZF Containing Proteins#zf-C2H2_2, zf-C2H2_4$#ENSP00000402292#ENSG00000198839#ENST00000450657#C2H2 ZF Containing Proteins#zf-C2H2_2, zf-C2H2_4, zf-Di19$#ENSP00000410538#ENSG00000198839#ENST00000421043#C2H2 ZF Containing Proteins#zf-C2H2_2$#ENSP00000415735#ENSG00000198839#ENST00000421864#C2H2 ZF Containing Proteins#zf-C2H2_2, zf-RVT$#ENSP00000390359#ENSG00000198839#ENST00000425229#C2H2 ZF Containing Proteins#zf-C2H2_2, zf-C2H2_4, zf-Di19 FALSE 998 ENSG00000243943 ZNF512 C2H2 ZF; BED ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Virtually nothing is known for this protein except that it has some of znfC2H2 domains and a znfBED domain and could thus be a TF IPR003593;IPR004130;IPR027417; 84450 GPN-loop GTPase 1 [Source:HGNC Symbol;Acc:HGNC:17030] None DBD and Full not tested None None b Yes No No 4a, two or more datasets predict it as a TF Yimeng Yin Arttu Jolma Yes None $#ENSP00000451572#ENSG00000243943#ENST00000556601#C2H2 ZF Containing Proteins#zf-C2H2_aberr$#ENSP00000347648#ENSG00000243943#ENST00000355467#C2H2 ZF Containing Proteins#zf-C2H2_aberr$#ENSP00000395660#ENSG00000243943#ENST00000413371#C2H2 ZF Containing Proteins#zf-C2H2_aberr$#ENSP00000407038#ENSG00000243943#ENST00000416005#C2H2 ZF Containing Proteins#zf-C2H2_aberr FALSE 999 ENSG00000148516 ZEB1 C2H2 ZF; Homeodomain Yes Known motif Monomer or homomultimer In vivo/Misc source None None IPR001356;IPR007087;IPR008598;IPR009057;IPR015880; 6935 zinc finger E-box binding homeobox 1 [Source:HGNC Symbol;Acc:HGNC:11642] None DBD and Full not tested None Jaspar ChIP-seq model has a robust and specific E-box like signal (as the name implies) a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:16129691 Yes 2a1, Lower confidence direct evidence Matt Weirauch Sam Lambert Yes $#ENSG00000148516#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IDA - PMID:23814079$#ENSG00000148516#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:8138542 $#ENSP00000319248#ENSG00000148516#ENST00000320985#C2H2 ZF Containing Proteins#$#ENSP00000354487#ENSG00000148516#ENST00000361642#C2H2 ZF Containing Proteins#$#ENSP00000453970#ENSG00000148516#ENST00000558440#C2H2 ZF Containing Proteins#$#ENSP00000444891#ENSG00000148516#ENST00000542815#C2H2 ZF Containing Proteins#$#ENSP00000453674#ENSG00000148516#ENST00000559476#C2H2 ZF Containing Proteins#$#ENSP00000452787#ENSG00000148516#ENST00000560721#C2H2 ZF Containing Proteins# FALSE 1000 ENSG00000169554 ZEB2 C2H2 ZF; Homeodomain Yes Inferred motif Monomer or homomultimer In vivo/Misc source None None IPR001356;IPR007087;IPR008598;IPR009057;IPR015880; 9839 zinc finger E-box binding homeobox 2 [Source:HGNC Symbol;Acc:HGNC:14881] None DBD and Full not tested None ZEB1 Jaspar model makes sense, and binds E-box like sequence as the name implies a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:11430829;12714599 Yes 2a2, orthologous lower confidence evidence Yimeng Yin Jussi Taipale Yes $#ENSG00000169554#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IDA - PMID:20516212 $#ENSP00000302501#ENSG00000169554#ENST00000303660#C2H2 ZF Containing Proteins#zf-C2H2_4, zf-H2C2_2$#ENSP00000376601#ENSG00000169554#ENST00000392861#C2H2 ZF Containing Proteins#$#ENSP00000395496#ENSG00000169554#ENST00000427902#C2H2 ZF Containing Proteins#zf-C2H2_4, zf-H2C2_2$#ENSP00000475329#ENSG00000169554#ENST00000470879#C2H2 ZF Containing Proteins#$#ENSP00000454157#ENSG00000169554#ENST00000558170#C2H2 ZF Containing Proteins#zf-C2H2_4, zf-H2C2_2$#ENSP00000487174#ENSG00000169554#ENST00000627532#C2H2 ZF Containing Proteins#zf-C2H2_4, zf-H2C2_2$#ENSP00000394777#ENSG00000169554#ENST00000419938#C2H2 ZF Containing Proteins#$#ENSP00000475502#ENSG00000169554#ENST00000465070#C2H2 ZF Containing Proteins#$#ENSP00000443792#ENSG00000169554#ENST00000539609#C2H2 ZF Containing Proteins#zf-C2H2_4, zf-H2C2_2$#ENSP00000486240#ENSG00000169554#ENST00000629520#C2H2 ZF Containing Proteins#$#ENSP00000490776#ENSG00000169554#ENST00000636026#C2H2 ZF Containing Proteins#zf-C2H2_4, zf-H2C2_2$#ENSP00000490508#ENSG00000169554#ENST00000636413#C2H2 ZF Containing Proteins#zf-C2H2_4, zf-H2C2_2$#ENSP00000490317#ENSG00000169554#ENST00000636471#C2H2 ZF Containing Proteins#zf-C2H2_4$#ENSP00000490141#ENSG00000169554#ENST00000637045#C2H2 ZF Containing Proteins#zf-C2H2_4, zf-H2C2_2$#ENSP00000490293#ENSG00000169554#ENST00000637267#C2H2 ZF Containing Proteins#zf-C2H2_4, zf-H2C2_2$#ENSP00000490872#ENSG00000169554#ENST00000637304#C2H2 ZF Containing Proteins#zf-C2H2_4, zf-H2C2_2$#ENSP00000489701#ENSG00000169554#ENST00000637873#C2H2 ZF Containing Proteins#$#ENSP00000490723#ENSG00000169554#ENST00000638007#C2H2 ZF Containing Proteins#zf-C2H2_4, zf-H2C2_2$#ENSP00000490673#ENSG00000169554#ENST00000638087#C2H2 ZF Containing Proteins#zf-C2H2_4, zf-H2C2_2$#ENSP00000490934#ENSG00000169554#ENST00000638128#C2H2 ZF Containing Proteins# FALSE 1001 ENSG00000140836 ZFHX3 C2H2 ZF; Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR003604;IPR007087;IPR009057;IPR015880;IPR017970 463 zinc finger homeobox 3 [Source:HGNC Symbol;Acc:HGNC:777] None Full Yes None None a Yes No Yes 1a1, Direct HQ evidence Sam Lambert Matt Weirauch Yes $#ENSG00000140836#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:1719379$#ENSG00000140836#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#TAS - PMID:1719379 $#ENSP00000268489#ENSG00000140836#ENST00000268489#C2H2 ZF Containing Proteins#zf-C2H2_4, zf-Di19, zf-H2C2_5, zf-met$#ENSP00000438926#ENSG00000140836#ENST00000397992#C2H2 ZF Containing Proteins#zf-C2H2_4, zf-Di19, zf-met FALSE 1002 ENSG00000091656 ZFHX4 C2H2 ZF; Homeodomain Yes Inferred motif Monomer or homomultimer In vivo/Misc source None Curious protein with numerous C2H2 and homeodomain-like domains. IPR001356;IPR003604;IPR007087;IPR009057;IPR015880;IPR017970 79776 Zinc finger homeobox 4 None not tested not tested None None b Yes No No 4a, two or more datasets predict it as a TF Matt Weirauch Tim Hughes Yes None $#ENSP00000427775#ENSG00000091656#ENST00000517585#C2H2 ZF Containing Proteins#$#ENSP00000428525#ENSG00000091656#ENST00000520307#C2H2 ZF Containing Proteins#$#ENSP00000427739#ENSG00000091656#ENST00000523809#C2H2 ZF Containing Proteins#$#ENSP00000429495#ENSG00000091656#ENST00000523885#C2H2 ZF Containing Proteins# FALSE 1003 ENSG00000124496 TRERF1 C2H2 ZF; Myb/SANT Yes Inferred motif Monomer or homomultimer In vivo/Misc source None Contains a SANT and multiple DNA-binding C2H2 domains. IPR000949;IPR001005;IPR007087;IPR009057;IPR015880;IPR017884 55809 transcriptional regulating factor 1 [Source:HGNC Symbol;Acc:HGNC:18273] None DBD not tested None None a Yes No Yes 2a1, Lower confidence direct evidence Tim Hughes Pratyush Das Yes $#ENSG00000124496#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:11349124 $#ENSP00000362008#ENSG00000124496#ENST00000372917#Myb, Myb-Like, and SANT Domain Containing Genes#ELM2$#ENSP00000362013#ENSG00000124496#ENST00000372922#Myb, Myb-Like, and SANT Domain Containing Genes#ELM2$#ENSP00000439689#ENSG00000124496#ENST00000541110#Myb, Myb-Like, and SANT Domain Containing Genes#ELM2 FALSE 1004 ENSG00000118156 ZNF541 C2H2 ZF; Myb/SANT Yes Known motif Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain Has good looking ZF arrays and possible Myb domains. IPR000949;IPR001005;IPR007087;IPR009057;IPR015880;IPR017884 84215 zinc finger protein 541 [Source:HGNC Symbol;Acc:HGNC:25294] None Full not tested None None b Yes No Yes 2a1, Lower confidence direct evidence Matt Weirauch Arttu Jolma Yes $#ENSG00000118156#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000263351#ENSG00000118156#ENST00000263351#C2H2 ZF Containing Proteins#$#ENSP00000471665#ENSG00000118156#ENST00000595558#C2H2 ZF Containing Proteins#ELM2$#ENSP00000313258#ENSG00000118156#ENST00000314121#C2H2 ZF Containing Proteins#ELM2$#ENSP00000375770#ENSG00000118156#ENST00000391901#C2H2 ZF Containing Proteins#ELM2 FALSE 1005 ENSG00000001167 NFYA CBF/NF-Y Yes Known motif Obligate heteromer In vivo/Misc source None Binds as a trimer with NFYB and NFYC. IPR001289;IPR018362 4800 nuclear transcription factor Y subunit alpha [Source:HGNC Symbol;Acc:HGNC:7804] 4AWL DBD not tested Obligate_Multimer obligate heterotrimer of NFYA, NFYB and NFYC a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:12070012;15601870 Yes 1a1, Direct HQ evidence Mihai Albu Jussi Taipale Yes $#ENSG00000001167#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002 $#ENSP00000345702#ENSG00000001167#ENST00000341376#NFY#$#ENSP00000229418#ENSG00000001167#ENST00000353205#NFY# FALSE 1006 ENSG00000160917 CPSF4 CCCH ZF No ssDNA/RNA binding Not a DNA binding protein No motif None None IPR000571;IPR001878 10898 cleavage and polyadenylation specific factor 4 [Source:HGNC Symbol;Acc:HGNC:2327] None not tested not tested None None x No No No 1a1, Direct HQ evidence Jussi Taipale Yimeng Yin No None $#ENSP00000292476#ENSG00000160917#ENST00000292476#CCCH ZF#zf-CCHC$#ENSP00000395311#ENSG00000160917#ENST00000436336#CCCH ZF#zf-CCHC$#ENSP00000402224#ENSG00000160917#ENST00000441580#CCCH ZF#zf-CCHC$#ENSP00000415188#ENSG00000160917#ENST00000440514#CCCH ZF#$#ENSP00000392584#ENSG00000160917#ENST00000452047#CCCH ZF# FALSE 1007 ENSG00000187959 CPSF4L CCCH ZF No ssDNA/RNA binding Not a DNA binding protein No motif None None IPR000571; 642843 cleavage and polyadenylation specific factor 4-like [Source:HGNC Symbol;Acc:HGNC:33632] None Full not tested None None x No No No 5a, one of the source datasets predicts is as a TF Sam Lambert Arttu Jolma No None $#ENSP00000343900#ENSG00000187959#ENST00000344935#CCCH ZF#$#ENSP00000380788#ENSG00000187959#ENST00000397671#CCCH ZF# FALSE 1008 ENSG00000163214 DHX57 CCCH ZF No ssDNA/RNA binding Not a DNA binding protein No motif None None IPR000571;IPR001650;IPR002464;IPR006575;IPR007502;IPR009060;IPR011545;IPR011709;IPR014001;IPR015940;IPR027417; 90957 DEAH-box helicase 57 [Source:HGNC Symbol;Acc:HGNC:20086] None Full not tested None None x No No No 5a, one of the source datasets predicts is as a TF Sam Lambert Pratyush Das No None $#ENSP00000405111#ENSG00000163214#ENST00000457308#CCCH ZF#AAA_14, AAA_19, AAA_22, DEAD, HA2, Helicase_C, NB-$#ENSP00000387404#ENSG00000163214#ENST00000442331#CCCH ZF#$#ENSP00000479840#ENSG00000163214#ENST00000619207#CCCH ZF#$#ENSP00000397841#ENSG00000163214#ENST00000452978#CCCH ZF#HA2, Helicase_C, OB_NTP_bind FALSE 1009 ENSG00000141994 DUS3L CCCH ZF No ssDNA/RNA binding Not a DNA binding protein No motif None None IPR000571;IPR001269;IPR018517; 56931 dihydrouridine synthase 3 like [Source:HGNC Symbol;Acc:HGNC:26920] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Sam Lambert Laura Campitelli No None $#ENSP00000311977#ENSG00000141994#ENST00000309061#CCCH ZF#Dus$#ENSP00000315558#ENSG00000141994#ENST00000320699#CCCH ZF#Dus$#ENSP00000466351#ENSG00000141994#ENST00000590343#CCCH ZF#$#ENSP00000467302#ENSG00000141994#ENST00000592491#CCCH ZF# FALSE 1010 ENSG00000198265 HELZ CCCH ZF No ssDNA/RNA binding Not a DNA binding protein No motif None None IPR000571;IPR027417 9931 helicase with zinc finger [Source:HGNC Symbol;Acc:HGNC:16878] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Yimeng Yin Laura Campitelli No None $#ENSP00000351524#ENSG00000198265#ENST00000358691#CCCH ZF#AAA_11, AAA_12, AAA_19, AAA_30, PAM2, PhoH, ResIII$#ENSP00000464512#ENSG00000198265#ENST00000580168#CCCH ZF#AAA_11, AAA_12, AAA_19, AAA_30, PAM2, PhoH, ResIII$#ENSP00000464354#ENSG00000198265#ENST00000578783#CCCH ZF#TetR_C_8$#ENSP00000462320#ENSG00000198265#ENST00000579861#CCCH ZF#TPR_1$#ENSP00000462763#ENSG00000198265#ENST00000581159#CCCH ZF#TPR_1, TPR_2 FALSE 1011 ENSG00000152601 MBNL1 CCCH ZF No ssDNA/RNA binding Not a DNA binding protein No motif None None IPR000571; 4154 muscleblind like splicing regulator 1 [Source:HGNC Symbol;Acc:HGNC:6923] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Yimeng Yin Sam Lambert No None $#ENSP00000319429#ENSG00000152601#ENST00000324210#CCCH ZF#$#ENSP00000347637#ENSG00000152601#ENST00000355460#CCCH ZF#$#ENSP00000418108#ENSG00000152601#ENST00000463374#CCCH ZF#$#ENSP00000417630#ENSG00000152601#ENST00000465907#CCCH ZF#$#ENSP00000418508#ENSG00000152601#ENST00000478535#CCCH ZF#$#ENSP00000418876#ENSG00000152601#ENST00000485509#CCCH ZF#$#ENSP00000418427#ENSG00000152601#ENST00000485910#CCCH ZF#$#ENSP00000420103#ENSG00000152601#ENST00000492948#CCCH ZF#$#ENSP00000419347#ENSG00000152601#ENST00000493459#CCCH ZF#$#ENSP00000417741#ENSG00000152601#ENST00000495875#CCCH ZF#$#ENSP00000420680#ENSG00000152601#ENST00000460591#CCCH ZF# FALSE 1012 ENSG00000139793 MBNL2 CCCH ZF Yes Likely to be sequence specific TF Monomer or homomultimer High-throughput in vitro None Has methylated and unmethylated HT-SELEX motifs, despite this family largely binding RNA exclusively (PMID: 28473536 ) IPR000571; 10150 muscleblind like splicing regulator 2 [Source:HGNC Symbol;Acc:HGNC:16746] None Full not tested None None x No No No 1a1, Direct HQ evidence Sam Lambert Yimeng Yin No None $#ENSP00000344214#ENSG00000139793#ENST00000343600#CCCH ZF#$#ENSP00000267287#ENSG00000139793#ENST00000345429#CCCH ZF#$#ENSP00000365861#ENSG00000139793#ENST00000376673#CCCH ZF#$#ENSP00000404202#ENSG00000139793#ENST00000449284#CCCH ZF# FALSE 1013 ENSG00000076770 MBNL3 CCCH ZF No ssDNA/RNA binding Not a DNA binding protein No motif None None IPR000571; 55796 muscleblind like splicing regulator 3 [Source:HGNC Symbol;Acc:HGNC:20564] None not tested not tested None None c No No No 5a, one of the source datasets predicts is as a TF Pratyush Das Jussi Taipale No None $#ENSP00000359876#ENSG00000076770#ENST00000370839#CCCH ZF#$#ENSP00000359881#ENSG00000076770#ENST00000370844#CCCH ZF#$#ENSP00000359890#ENSG00000076770#ENST00000370853#CCCH ZF#$#ENSP00000439618#ENSG00000076770#ENST00000538204#CCCH ZF#$#ENSP00000359886#ENSG00000076770#ENST00000370849#CCCH ZF#$#ENSP00000377848#ENSG00000076770#ENST00000394311#CCCH ZF#$#ENSP00000412065#ENSG00000076770#ENST00000442191#CCCH ZF#$#ENSP00000406014#ENSG00000076770#ENST00000436215#CCCH ZF# FALSE 1014 ENSG00000133606 MKRN1 CCCH ZF No ssDNA/RNA binding Not a DNA binding protein No motif None None IPR000571;IPR001841;IPR017907;IPR018957 23608 makorin ring finger protein 1 [Source:HGNC Symbol;Acc:HGNC:7112] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Pratyush Das Laura Campitelli No None $#ENSP00000255977#ENSG00000133606#ENST00000255977#CCCH ZF#MKRN1_C, zf-ANAPC11, zf-C3HC4, zf-C3HC4_4, zf-RING$#ENSP00000416369#ENSG00000133606#ENST00000443720#CCCH ZF#zf-ANAPC11, zf-C3HC4, zf-C3HC4_2, zf-C3HC4_4, zf-R$#ENSP00000418620#ENSG00000133606#ENST00000473444#CCCH ZF#$#ENSP00000419843#ENSG00000133606#ENST00000494939#CCCH ZF# FALSE 1015 ENSG00000075975 MKRN2 CCCH ZF No ssDNA/RNA binding Not a DNA binding protein No motif None None IPR000571;IPR001841;IPR017907;IPR018957 23609 makorin ring finger protein 2 [Source:HGNC Symbol;Acc:HGNC:7113] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Matt Weirauch Jussi Taipale No None $#ENSP00000170447#ENSG00000075975#ENST00000170447#CCCH ZF#zf-C3HC4, zf-C3HC4_4, zf-RING_11, zf-RING_2, zf-RI$#ENSP00000396340#ENSG00000075975#ENST00000411987#CCCH ZF#zf-C3HC4, zf-C3HC4_4, zf-RING_2, zf-RING_5, zf-RIN$#ENSP00000397983#ENSG00000075975#ENST00000448482#CCCH ZF#zf-C3HC4, zf-C3HC4_4, zf-RING_11, zf-RING_2, zf-RI FALSE 1016 ENSG00000136243 NUPL2 CCCH ZF No ssDNA/RNA binding Not a DNA binding protein No motif None None IPR000571; 11097 nucleoporin like 2 [Source:HGNC Symbol;Acc:HGNC:17010] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Laura Campitelli Yimeng Yin No None $#ENSP00000258742#ENSG00000136243#ENST00000258742#CCCH ZF#$#ENSP00000387330#ENSG00000136243#ENST00000410002#CCCH ZF#$#ENSP00000401475#ENSG00000136243#ENST00000413919#CCCH ZF#$#ENSP00000482736#ENSG00000136243#ENST00000548367#CCCH ZF# FALSE 1017 ENSG00000059378 PARP12 CCCH ZF No ssDNA/RNA binding Not a DNA binding protein No motif None Likely an RNA binding protein (PMID: 25086041). IPR000571;IPR004170;IPR012317; 64761 poly(ADP-ribose) polymerase family member 12 [Source:HGNC Symbol;Acc:HGNC:21919] None Full not tested None None x No Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0;15273990;; No 4a, two or more datasets predict it as a TF Pratyush Das Matt Weirauch No None $#ENSP00000263549#ENSG00000059378#ENST00000263549#CCCH ZF#PARP, Torus, WWE$#ENSP00000417606#ENSG00000059378#ENST00000489809#CCCH ZF#$#ENSP00000418640#ENSG00000059378#ENST00000484111#CCCH ZF#PARP FALSE 1018 ENSG00000204569 PPP1R10 CCCH ZF No ssDNA/RNA binding Not a DNA binding protein No motif None Close ortholog (PP1RA) binds to mRNA, single-stranded DNA (ssDNA), poly(A) and poly(G) homopolymers (Uniprot). IPR000571;IPR003617;IPR017923; 5514 protein phosphatase 1 regulatory subunit 10 [Source:HGNC Symbol;Acc:HGNC:9284] None Full not tested None None x No No No 5a, one of the source datasets predicts is as a TF Laura Campitelli Arttu Jolma No None $#ENSP00000365694#ENSG00000204569#ENST00000376511#CCCH ZF#Med26 FALSE 1019 ENSG00000204576 PRR3 CCCH ZF No ssDNA/RNA binding Not a DNA binding protein No motif None None IPR000571; 80742 proline rich 3 [Source:HGNC Symbol;Acc:HGNC:21149] None Full not tested None None x No No No 5a, one of the source datasets predicts is as a TF Pratyush Das Sam Lambert No None $#ENSP00000365744#ENSG00000204576#ENST00000376560#CCCH ZF#$#ENSP00000365740#ENSG00000204576#ENST00000376557#CCCH ZF# FALSE 1020 ENSG00000135870 RC3H1 CCCH ZF No ssDNA/RNA binding Not a DNA binding protein No motif None A well established RNA-binding protein reviewed in (PMID: 26489670). IPR000571;IPR001841;IPR017907; 149041 ring finger and CCCH-type domains 1 [Source:HGNC Symbol;Acc:HGNC:29434] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Arttu Jolma Pratyush Das No None $#ENSP00000258349#ENSG00000135870#ENST00000258349#CCCH ZF#FYVE, Prok-RING_4, zf-C3HC4, zf-C3HC4_2, zf-C3HC4_$#ENSP00000356667#ENSG00000135870#ENST00000367694#CCCH ZF#FYVE, Prok-RING_4, zf-C3HC4, zf-C3HC4_2, zf-C3HC4_$#ENSP00000356669#ENSG00000135870#ENST00000367696#CCCH ZF#FYVE, Prok-RING_4, zf-C3HC4, zf-C3HC4_2, zf-C3HC4_ FALSE 1021 ENSG00000056586 RC3H2 CCCH ZF No ssDNA/RNA binding Not a DNA binding protein No motif None None IPR000571;IPR001841;IPR017907; 54542 ring finger and CCCH-type domains 2 [Source:HGNC Symbol;Acc:HGNC:21461] None not tested not tested None None c No No No 5a, one of the source datasets predicts is as a TF Jussi Taipale Matt Weirauch Yes None $#ENSP00000335150#ENSG00000056586#ENST00000335387#CCCH ZF#Prok-RING_4, zf-C3HC4, zf-C3HC4_2, zf-C3HC4_4, zf-$#ENSP00000474148#ENSG00000056586#ENST00000471874#CCCH ZF#FYVE, Prok-RING_4, zf-C3HC4, zf-C3HC4_2, zf-C3HC4_ FALSE 1022 ENSG00000125352 RNF113A CCCH ZF No ssDNA/RNA binding Not a DNA binding protein No motif None None IPR000571;IPR001841;IPR017907; 7737 ring finger protein 113A [Source:HGNC Symbol;Acc:HGNC:12974] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Tim Hughes Yimeng Yin No None $#ENSP00000360497#ENSG00000125352#ENST00000371442#CCCH ZF#zf-C3HC4, zf-C3HC4_2, zf-C3HC4_3, zf-C3HC4_4, zf-N FALSE 1023 ENSG00000139797 RNF113B CCCH ZF No ssDNA/RNA binding Not a DNA binding protein No motif None None IPR000571;IPR001841;IPR017907; 140432 ring finger protein 113B [Source:HGNC Symbol;Acc:HGNC:17267] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Sam Lambert Arttu Jolma No None $#ENSP00000267291#ENSG00000139797#ENST00000267291#CCCH ZF#zf-C3HC4, zf-C3HC4_2, zf-C3HC4_3, zf-C3HC4_4, zf-N FALSE 1024 ENSG00000132773 TOE1 CCCH ZF No ssDNA/RNA binding Not a DNA binding protein No motif None None IPR000571;IPR006941;IPR012337; 114034 target of EGR1, member 1 (nuclear) [Source:HGNC Symbol;Acc:HGNC:15954] None DBD and Full not tested None None b No No No 5a, one of the source datasets predicts is as a TF Jussi Taipale Tim Hughes No None $#ENSP00000361162#ENSG00000132773#ENST00000372090#CCCH ZF#CAF1 FALSE 1025 ENSG00000104907 TRMT1 CCCH ZF No ssDNA/RNA binding Not a DNA binding protein No motif None None IPR000571;IPR002905;IPR029063; 55621 tRNA methyltransferase 1 [Source:HGNC Symbol;Acc:HGNC:25980] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Matt Weirauch Tim Hughes No None $#ENSP00000221504#ENSG00000104907#ENST00000221504#CCCH ZF#Cons_hypoth95, Met_10, TRM$#ENSP00000416149#ENSG00000104907#ENST00000437766#CCCH ZF#Cons_hypoth95, Met_10, TRM$#ENSP00000350352#ENSG00000104907#ENST00000357720#CCCH ZF#Cons_hypoth95, Met_10, TRM$#ENSP00000467984#ENSG00000104907#ENST00000588229#CCCH ZF#TRM$#ENSP00000465370#ENSG00000104907#ENST00000587487#CCCH ZF#TRM$#ENSP00000467938#ENSG00000104907#ENST00000592814#CCCH ZF#Cons_hypoth95, Met_10, TRM FALSE 1026 ENSG00000132478 UNK CCCH ZF No ssDNA/RNA binding Not a DNA binding protein No motif None None IPR000571; 85451 unkempt family zinc finger [Source:HGNC Symbol;Acc:HGNC:29369] None not tested Yes None None x No No No 5a, one of the source datasets predicts is as a TF Jussi Taipale Sam Lambert No None $#ENSP00000464893#ENSG00000132478#ENST00000589666#CCCH ZF#Alanine_zipper, DUF3450, DUF4407, Fez1, THOC7, zf-$#ENSP00000467726#ENSG00000132478#ENST00000587258#CCCH ZF#APG6, Alanine_zipper, CENP-Q, DUF3450, DUF4407, Fe FALSE 1027 ENSG00000059145 UNKL CCCH ZF No ssDNA/RNA binding Not a DNA binding protein No motif None None IPR000571;IPR001841 64718 Unkempt family like zinc finger [Source:HGNC Symbol;Acc:HGNC:14184] None not tested not tested None None c No No No 5a, one of the source datasets predicts is as a TF Laura Campitelli Sam Lambert No None $#ENSP00000248104#ENSG00000059145#ENST00000248104#CCCH ZF#DUF3450, Filament, Mnd1, Prok-RING_4, zf-C3HC4_3, $#ENSP00000301712#ENSG00000059145#ENST00000301712#CCCH ZF#$#ENSP00000380606#ENSG00000059145#ENST00000397464#CCCH ZF#Filament, Prok-RING_4, zf-C3HC4_3, zf-RING_5$#ENSP00000384850#ENSG00000059145#ENST00000402641#CCCH ZF#Filament, Halogen_Hydrol FALSE 1028 ENSG00000135482 ZC3H10 CCCH ZF No ssDNA/RNA binding Not a DNA binding protein No motif None None IPR000571; 84872 zinc finger CCCH-type containing 10 [Source:HGNC Symbol;Acc:HGNC:25893] None not tested Yes None RBP x Yes No No 4a, two or more datasets predict it as a TF Tim Hughes Matt Weirauch No None $#ENSP00000257940#ENSG00000135482#ENST00000257940#CCCH ZF#$#ENSP00000448881#ENSG00000135482#ENST00000546903#CCCH ZF#$#ENSP00000448309#ENSG00000135482#ENST00000551880#CCCH ZF#$#ENSP00000450122#ENSG00000135482#ENST00000552345#CCCH ZF# FALSE 1029 ENSG00000058673 ZC3H11A CCCH ZF No ssDNA/RNA binding Not a DNA binding protein No motif None None IPR000571; 9877 zinc finger CCCH-type containing 11A [Source:HGNC Symbol;Acc:HGNC:29093] None not tested not tested None None c No No No 5a, one of the source datasets predicts is as a TF Laura Campitelli Yimeng Yin No None $#ENSP00000333253#ENSG00000058673#ENST00000332127#Other#zf-CCCH_3$#ENSP00000356179#ENSG00000058673#ENST00000367210#Other#zf-CCCH_3$#ENSP00000356181#ENSG00000058673#ENST00000367212#Other#zf-CCCH_3$#ENSP00000438527#ENSG00000058673#ENST00000545588#Other#zf-CCCH_3$#ENSP00000356183#ENSG00000058673#ENST00000367214#Other#zf-CCCH_3 FALSE 1030 ENSG00000163874 ZC3H12A CCCH ZF No ssDNA/RNA binding Not a DNA binding protein No motif None None IPR021869 102465438 zinc finger CCCH-type containing 12A [Source:HGNC Symbol;Acc:HGNC:26259];Endoribonuclease ZC3H12A None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Sam Lambert Pratyush Das No $#ENSG00000163874#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IDA - PMID:18178554 $#ENSP00000362179#ENSG00000163874#ENST00000373087#Other#RNase_Zc3h12a$#ENSP00000473447#ENSG00000163874#ENST00000471012#Other#RNase_Zc3h12a FALSE 1031 ENSG00000123200 ZC3H13 CCCH ZF No ssDNA/RNA binding Not a DNA binding protein No motif None None IPR000571; 23091 zinc finger CCCH-type containing 13 [Source:HGNC Symbol;Acc:HGNC:20368] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Yimeng Yin Jussi Taipale No None $#ENSP00000282007#ENSG00000123200#ENST00000282007#CCCH ZF#$#ENSP00000480658#ENSG00000123200#ENST00000464597#CCCH ZF#DUF3736$#ENSP00000416238#ENSG00000123200#ENST00000428921#CCCH ZF#$#ENSP00000242848#ENSG00000123200#ENST00000242848#CCCH ZF# FALSE 1032 ENSG00000100722 ZC3H14 CCCH ZF No ssDNA/RNA binding Not a DNA binding protein No motif None Binds UUUNUUU RNA-sequence based on Ray et al 2013 (PMID: 23846655). IPR000571; 79882 zinc finger CCCH-type containing 14 [Source:HGNC Symbol;Acc:HGNC:20509] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Jussi Taipale Arttu Jolma No None $#ENSP00000251038#ENSG00000100722#ENST00000251038#Other#zf-CCCH_2$#ENSP00000307025#ENSG00000100722#ENST00000302216#Other#zf-CCCH_2$#ENSP00000327176#ENSG00000100722#ENST00000318308#Other#zf-CCCH_2$#ENSP00000338002#ENSG00000100722#ENST00000336693#Other#zf-CCCH_2$#ENSP00000451054#ENSG00000100722#ENST00000556000#Other#zf-CCCH_2$#ENSP00000452475#ENSG00000100722#ENST00000555755#Other#zf-CCCH_2$#ENSP00000384682#ENSG00000100722#ENST00000406216#Other#zf-CCCH_2$#ENSP00000450823#ENSG00000100722#ENST00000555792#Other#zf-CCCH_2, zf-TAZ$#ENSP00000451489#ENSG00000100722#ENST00000555799#Other#$#ENSP00000451389#ENSG00000100722#ENST00000556158#Other#$#ENSP00000477763#ENSG00000100722#ENST00000557047#Other#$#ENSP00000452210#ENSG00000100722#ENST00000557693#Other# FALSE 1033 ENSG00000065548 ZC3H15 CCCH ZF No ssDNA/RNA binding Not a DNA binding protein No motif None None IPR000571; 55854 zinc finger CCCH-type containing 15 [Source:HGNC Symbol;Acc:HGNC:29528] None not tested not tested None None c No No No 5a, one of the source datasets predicts is as a TF Yimeng Yin Matt Weirauch No None $#ENSP00000338788#ENSG00000065548#ENST00000337859#CCCH ZF#DFRP_C, Torus$#ENSP00000415788#ENSG00000065548#ENST00000445547#CCCH ZF# FALSE 1034 ENSG00000158545 ZC3H18 CCCH ZF No ssDNA/RNA binding Not a DNA binding protein No motif None None IPR000571; 124245 zinc finger CCCH-type containing 18 [Source:HGNC Symbol;Acc:HGNC:25091] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Matt Weirauch Jussi Taipale No None $#ENSP00000301011#ENSG00000158545#ENST00000301011#CCCH ZF#$#ENSP00000416951#ENSG00000158545#ENST00000452588#CCCH ZF#$#ENSP00000456241#ENSG00000158545#ENST00000565583#CCCH ZF# FALSE 1035 ENSG00000014164 ZC3H3 CCCH ZF No ssDNA/RNA binding Not a DNA binding protein No motif None None IPR000571; 23144 zinc finger CCCH-type containing 3 [Source:HGNC Symbol;Acc:HGNC:28972] None not tested not tested None None c No No No 5a, one of the source datasets predicts is as a TF Yimeng Yin Tim Hughes No None $#ENSP00000262577#ENSG00000014164#ENST00000262577#CCCH ZF#$#ENSP00000436834#ENSG00000014164#ENST00000528401#CCCH ZF# FALSE 1036 ENSG00000130749 ZC3H4 CCCH ZF No ssDNA/RNA binding Not a DNA binding protein No motif Has a putative AT-hook None IPR000571; 23211 zinc finger CCCH-type containing 4 [Source:HGNC Symbol;Acc:HGNC:17808] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Pratyush Das Matt Weirauch Yes None $#ENSP00000253048#ENSG00000130749#ENST00000253048#CCCH ZF#$#ENSP00000469684#ENSG00000130749#ENST00000601973#CCCH ZF# FALSE 1037 ENSG00000188177 ZC3H6 CCCH ZF No ssDNA/RNA binding Not a DNA binding protein No motif None None IPR000571; 376940 zinc finger CCCH-type containing 6 [Source:HGNC Symbol;Acc:HGNC:24762] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Pratyush Das Arttu Jolma Yes None $#ENSP00000386764#ENSG00000188177#ENST00000409871#CCCH ZF#$#ENSP00000340298#ENSG00000188177#ENST00000343936#CCCH ZF# FALSE 1038 ENSG00000122299 ZC3H7A CCCH ZF No ssDNA/RNA binding Not a DNA binding protein No motif None None IPR000571;IPR022755 29066 zinc finger CCCH-type containing 7A [Source:HGNC Symbol;Acc:HGNC:30959] None not tested Yes None None x No No No 5a, one of the source datasets predicts is as a TF Laura Campitelli Arttu Jolma No None $#ENSP00000347999#ENSG00000122299#ENST00000355758#CCCH ZF#TPR_2, zf-C2H2_jaz$#ENSP00000379773#ENSG00000122299#ENST00000396516#CCCH ZF#TPR_2, zf-C2H2_jaz$#ENSP00000459477#ENSG00000122299#ENST00000575984#CCCH ZF#zf-C2H2_jaz, zf-met$#ENSP00000459747#ENSG00000122299#ENST00000571198#CCCH ZF#TPR_2$#ENSP00000460122#ENSG00000122299#ENST00000576009#CCCH ZF# FALSE 1039 ENSG00000100403 ZC3H7B CCCH ZF No ssDNA/RNA binding Not a DNA binding protein No motif None None IPR000571;IPR013026;IPR019734; 23264 Zinc finger CCCH-type containing 7B [Source:HGNC Symbol;Acc:HGNC:30869] None Full not tested None None x No No No 5a, one of the source datasets predicts is as a TF Yimeng Yin Arttu Jolma No None $#ENSP00000345793#ENSG00000100403#ENST00000352645#CCCH ZF#ANAPC3, TPR_1, TPR_12, TPR_2, TPR_8, zf-C2H2_2 FALSE 1040 ENSG00000144161 ZC3H8 CCCH ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Mouse ortholog can bind DNA specifically, based on EMSA (PMID: 12077251). IPR000571; 84524 zinc finger CCCH-type containing 8 [Source:HGNC Symbol;Acc:HGNC:30941] None not tested not tested None RBP x No TF Gene Candidate_DNA-Binding: sequence-specific_DNA Binding; Other_PMIDS:12077251 Yes 4a, two or more datasets predict it as a TF Laura Campitelli Matt Weirauch Yes $#ENSG00000144161#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IEA - GO_REF:0000019$#ENSG00000144161#GO:0003700#sequence-specific DNA binding transcription factor activity#IMP - PMID:12153508 $#ENSP00000272570#ENSG00000144161#ENST00000272570#CCCH ZF#$#ENSP00000386488#ENSG00000144161#ENST00000409573#CCCH ZF#$#ENSP00000483976#ENSG00000144161#ENST00000615791#CCCH ZF# FALSE 1041 ENSG00000105939 ZC3HAV1 CCCH ZF No ssDNA/RNA binding Not a DNA binding protein No motif None RNA-binding protein (PMID: 22658674; PMID: 22681889). IPR000571;IPR004170;IPR012317; 56829 zinc finger CCCH-type containing, antiviral 1 [Source:HGNC Symbol;Acc:HGNC:23721] None Full not tested None None x No No No 5a, one of the source datasets predicts is as a TF Laura Campitelli Pratyush Das No None $#ENSP00000242351#ENSG00000105939#ENST00000242351#Other#PARP, WWE$#ENSP00000420107#ENSG00000105939#ENST00000460845#Other#WWE$#ENSP00000419855#ENSG00000105939#ENST00000471652#Other#WWE$#ENSP00000418385#ENSG00000105939#ENST00000464606#Other#PARP, WWE FALSE 1042 ENSG00000128016 ZFP36 CCCH ZF No ssDNA/RNA binding Not a DNA binding protein No motif None RNA binding protein (PMID: 10330172). IPR000571; 7538 ZFP36 ring finger protein [Source:HGNC Symbol;Acc:HGNC:12862] None not tested not tested None None x No Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0 No 4a, two or more datasets predict it as a TF Pratyush Das Sam Lambert No None $#ENSP00000469647#ENSG00000128016#ENST00000597629#CCCH ZF#$#ENSP00000472329#ENSG00000128016#ENST00000594045#CCCH ZF#$#ENSP00000470200#ENSG00000128016#ENST00000600033#CCCH ZF#$#ENSP00000471239#ENSG00000128016#ENST00000594442#CCCH ZF# FALSE 1043 ENSG00000185650 ZFP36L1 CCCH ZF No ssDNA/RNA binding Not a DNA binding protein No motif None RNA-binding protein (PMID: 27102483; PMID: 17013884). IPR000571;IPR007635 677 ZFP36 ring finger protein-like 1 [Source:HGNC Symbol;Acc:HGNC:1107] None DBD and Full not tested None None b No Probably Not a TF - No evidence that it is a TF___PMIDS:0 Yes 4a, two or more datasets predict it as a TF Sam Lambert Arttu Jolma No $#ENSG00000185650#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:8595910 $#ENSP00000388402#ENSG00000185650#ENST00000439696#CCCH ZF#Tis11B_N$#ENSP00000337386#ENSG00000185650#ENST00000336440#CCCH ZF#Tis11B_N$#ENSP00000452119#ENSG00000185650#ENST00000553375#CCCH ZF#Tis11B_N$#ENSP00000450784#ENSG00000185650#ENST00000557086#CCCH ZF#Tis11B_N$#ENSP00000451093#ENSG00000185650#ENST00000555997#CCCH ZF# FALSE 1044 ENSG00000152518 ZFP36L2 CCCH ZF No ssDNA/RNA binding Not a DNA binding protein No motif None RNA-binding protein (PMID: 20506496). IPR000571;IPR007635 678 ZFP36 ring finger protein-like 2 [Source:HGNC Symbol;Acc:HGNC:1108] None DBD not tested None None b No No Yes 4a, two or more datasets predict it as a TF Jussi Taipale Pratyush Das No $#ENSG00000152518#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:7835719 $#ENSP00000282388#ENSG00000152518#ENST00000282388#CCCH ZF#Tis11B_N FALSE 1045 ENSG00000197114 ZGPAT CCCH ZF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Binds RRRGGAGGAGA based on SELEX and EMSA (PMID: 19644445). IPR000467;IPR000571 84619 zinc finger CCCH-type and G-patch domain containing [Source:HGNC Symbol;Acc:HGNC:15948] None not tested not tested None None x No No Yes 4a, two or more datasets predict it as a TF Arttu Jolma Pratyush Das Yes $#ENSG00000197114#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:19644445$#ENSG00000197114#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:19644445 $#ENSP00000348242#ENSG00000197114#ENST00000355969#CCCH ZF#G-patch, Laminin_I$#ENSP00000349634#ENSG00000197114#ENST00000357119#CCCH ZF#G-patch, Laminin_I$#ENSP00000391176#ENSG00000197114#ENST00000448100#CCCH ZF#G-patch, Laminin_I$#ENSP00000332013#ENSG00000197114#ENST00000328969#CCCH ZF#G-patch, Laminin_I$#ENSP00000403966#ENSG00000197114#ENST00000431125#CCCH ZF# FALSE 1046 ENSG00000100319 ZMAT5 CCCH ZF No ssDNA/RNA binding Not a DNA binding protein No motif None None IPR000571;IPR013085 55954 zinc finger matrin-type 5 [Source:HGNC Symbol;Acc:HGNC:28046] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Jussi Taipale Tim Hughes No None $#ENSP00000344241#ENSG00000100319#ENST00000344318#CCCH ZF#zf-U1 FALSE 1047 ENSG00000212643 ZRSR1 CCCH ZF No ssDNA/RNA binding Not a DNA binding protein No motif None None IPR000504;IPR000571;IPR003954;IPR009145 None zinc finger CCCH-type, RNA binding motif and serine/arginine rich 1 [Source:HGNC Symbol;Acc:HGNC:124 None Full not tested None None x No Not a TF - Evidence that it is not a TF__Other_PMIDS:14673161 No 5a, one of the source datasets predicts is as a TF Laura Campitelli Arttu Jolma No None $#ENSP00000375133#ENSG00000212643#ENST00000391338#Other# FALSE 1048 ENSG00000169249 ZRSR2 CCCH ZF No ssDNA/RNA binding Not a DNA binding protein No motif None None IPR000504;IPR000571;IPR003954;IPR009145 8233 zinc finger CCCH-type, RNA binding motif and serine/arginine rich 2 [Source:HGNC Symbol;Acc:HGNC:230 None Full Yes None None x No No No 5a, one of the source datasets predicts is as a TF Jussi Taipale Arttu Jolma No None $#ENSP00000303015#ENSG00000169249#ENST00000307771#Other#$#ENSP00000369664#ENSG00000169249#ENST00000380308#Other# FALSE 1049 ENSG00000125817 CENPB CENPB Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR004875;IPR006600;IPR007889;IPR009057;IPR015115; 1059 centromere protein B [Source:HGNC Symbol;Acc:HGNC:1852] 1HLV Full not tested None Structure has many contacts between the AA-residues and the DNA-bases in the major groove, could well be sequence-specific x Yes No No 1a1, Direct HQ evidence Sam Lambert Matt Weirauch No None $#ENSP00000369075#ENSG00000125817#ENST00000379751#CENP-B N-terminal DNA-binding domain#CENP-B_dimeris, DDE_1, HTH_Tnp_Tc5 FALSE 1050 ENSG00000177946 CENPBD1 CENPB Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR006600;IPR007889;IPR009057; 92806 CENPB DNA-binding domain containing 1 [Source:HGNC Symbol;Acc:HGNC:28272] None not tested Yes None None No Yes No No 1a1, Direct HQ evidence Sam Lambert Arttu Jolma No None $#ENSP00000393854#ENSG00000177946#ENST00000314994#CENP-B N-terminal DNA-binding domain#HTH_Tnp_Tc5 FALSE 1051 ENSG00000234616 JRK CENPB Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR004875;IPR006600;IPR007889;IPR009057 8629 Jrk helix-turn-helix protein [Source:HGNC Symbol;Acc:HGNC:6199] None not tested not tested None None No Yes No No 5a, one of the source datasets predicts is as a TF Yimeng Yin Pratyush Das No None $#ENSP00000461610#ENSG00000234616#ENST00000571961#CENP-B N-terminal DNA-binding domain#DDE_1, HTH_Tnp_Tc5$#ENSP00000485390#ENSG00000234616#ENST00000614134#CENP-B N-terminal DNA-binding domain#DDE_1, HTH_Tnp_Tc5$#ENSP00000483808#ENSG00000234616#ENST00000615982#CENP-B N-terminal DNA-binding domain#DDE_1, HTH_Tnp_Tc5$#ENSP00000482410#ENSG00000234616#ENST00000612905#CENP-B N-terminal DNA-binding domain#DDE_1, HTH_Tnp_Tc5 FALSE 1052 ENSG00000183340 JRKL CENPB Yes Inferred motif Monomer or homomultimer High-throughput in vitro None None IPR004875;IPR006600;IPR007889;IPR009057 8690 JRK-like [Source:HGNC Symbol;Acc:HGNC:6200] None Full not tested None None x Yes No No 4a, two or more datasets predict it as a TF Arttu Jolma Laura Campitelli No None $#ENSP00000333350#ENSG00000183340#ENST00000332349#CENP-B N-terminal DNA-binding domain#DDE_1, HTH_Tnp_Tc5 FALSE 1053 ENSG00000221944 TIGD1 CENPB Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR004875;IPR006600;IPR007889;IPR009057 100847037 tigger transposable element derived 1 [Source:HGNC Symbol;Acc:HGNC:14523] None not tested Yes None None No Yes No No 1a1, Direct HQ evidence Sam Lambert Pratyush Das No None $#ENSP00000386186#ENSG00000221944#ENST00000408957#CENP-B N-terminal DNA-binding domain#DDE_1, HTH_Tnp_Tc5 FALSE 1054 ENSG00000180346 TIGD2 CENPB Yes Inferred motif Monomer or homomultimer High-throughput in vitro None None IPR004875;IPR006600;IPR007889;IPR009057 166815 tigger transposable element derived 2 [Source:HGNC Symbol;Acc:HGNC:18333] None not tested not tested None None x Yes No No 4a, two or more datasets predict it as a TF Yimeng Yin Laura Campitelli No None $#ENSP00000486687#ENSG00000180346#ENST00000603357#CENP-B N-terminal DNA-binding domain#DDE_1, HTH_Tnp_Tc5$#ENSP00000317170#ENSG00000180346#ENST00000317005#CENP-B N-terminal DNA-binding domain#DDE_1, HTH_Tnp_Tc5 FALSE 1055 ENSG00000173825 TIGD3 CENPB Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR004875;IPR006600;IPR007889;IPR009057 220359 tigger transposable element derived 3 [Source:HGNC Symbol;Acc:HGNC:18334] None Full not tested None None x Yes No No 4a, two or more datasets predict it as a TF Laura Campitelli Arttu Jolma No None $#ENSP00000308354#ENSG00000173825#ENST00000309880#CENP-B N-terminal DNA-binding domain#DDE_1, HTH_Tnp_Tc5 FALSE 1056 ENSG00000169989 TIGD4 CENPB Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Evidence showing that the two HTH domains in the protein together bind specifically to a 17-base-pair sequence; the CENP-B box; which occurs in alpha-satellite DNA in human centromeres (PMID: 16183641). IPR004875;IPR006600;IPR007889;IPR009057 201798 tigger transposable element derived 4 [Source:HGNC Symbol;Acc:HGNC:18335] None not tested not tested None None x Yes No No 4a, two or more datasets predict it as a TF Pratyush Das Yimeng Yin No None $#ENSP00000355162#ENSG00000169989#ENST00000304337#CENP-B N-terminal DNA-binding domain#CENP-B_dimeris, DDE_1, HTH_Tnp_Tc5 FALSE 1057 ENSG00000179886 TIGD5 CENPB Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR004875;IPR006600;IPR007889;IPR009057 84948 tigger transposable element derived 5 [Source:HGNC Symbol;Acc:HGNC:18336] None not tested not tested None None x Yes No No 4a, two or more datasets predict it as a TF Jussi Taipale Arttu Jolma No None $#ENSP00000421489#ENSG00000179886#ENST00000504548#CENP-B N-terminal DNA-binding domain#DDE_1, HTH_Tnp_Tc5 FALSE 1058 ENSG00000164296 TIGD6 CENPB Yes Inferred motif Monomer or homomultimer High-throughput in vitro None None IPR004875;IPR006600;IPR007889;IPR009057 81789 tigger transposable element derived 6 [Source:HGNC Symbol;Acc:HGNC:18332] None Full not tested None None x Yes No No 4a, two or more datasets predict it as a TF Sam Lambert Laura Campitelli No None $#ENSP00000296736#ENSG00000164296#ENST00000296736#CENP-B N-terminal DNA-binding domain#DDE_1, HTH_Tnp_Tc5$#ENSP00000425318#ENSG00000164296#ENST00000515406#CENP-B N-terminal DNA-binding domain#DDE_1, HTH_Tnp_Tc5 FALSE 1059 ENSG00000140993 TIGD7 CENPB Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR004875;IPR006600;IPR007889;IPR009057 91151 tigger transposable element derived 7 [Source:HGNC Symbol;Acc:HGNC:18331] None not tested not tested None None x Yes No No 4a, two or more datasets predict it as a TF Arttu Jolma Pratyush Das No None $#ENSP00000380071#ENSG00000140993#ENST00000396862#CENP-B N-terminal DNA-binding domain#DDE_1, HTH_Tnp_Tc5$#ENSP00000459534#ENSG00000140993#ENST00000573608#CENP-B N-terminal DNA-binding domain#HTH_Tnp_Tc5 FALSE 1060 ENSG00000171735 CAMTA1 CG-1 Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Binds CGCATTGCG based on EMSA performed in (PMID: 25049392) IPR000048;IPR002110;IPR002909;IPR005559;IPR014756;IPR020683;IPR027417; 23261 calmodulin binding transcription activator 1 [Source:HGNC Symbol;Acc:HGNC:18806] None DBD and Full not tested None None b Yes No Yes 4a, two or more datasets predict it as a TF Laura Campitelli Arttu Jolma No $#ENSG00000171735#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IBA - GO_REF:0000033 $#ENSP00000306522#ENSG00000171735#ENST00000303635#CG-1#Ank_2, Ank_3, Ank_4, Ank_5, IQ, TIG$#ENSP00000451388#ENSG00000171735#ENST00000473578#CG-1#$#ENSP00000452319#ENSG00000171735#ENST00000476864#CG-1#IQ$#ENSP00000452024#ENSG00000171735#ENST00000490905#CG-1#IQ$#ENSP00000451720#ENSG00000171735#ENST00000495233#CG-1#Ank, Ank_2, Ank_3, Ank_4, Ank_5, IQ$#ENSP00000451510#ENSG00000171735#ENST00000557126#CG-1#$#ENSP00000450530#ENSG00000171735#ENST00000467404#CG-1# FALSE 1061 ENSG00000108509 CAMTA2 CG-1 Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR000048;IPR002909;IPR005559;IPR014756;IPR020683;IPR027417 23125 calmodulin binding transcription activator 2 [Source:HGNC Symbol;Acc:HGNC:18807] None DBD and Full not tested None None b Yes TF Gene_Transcription Factor Binding: tf co-factor binding_Co-activation; TF PPI_PMIDS:16678093 Yes 4a, two or more datasets predict it as a TF Yimeng Yin Jussi Taipale No $#ENSG00000108509#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IBA - GO_REF:0000033 $#ENSP00000321813#ENSG00000108509#ENST00000348066#CG-1#Ank_2, Ank_3, Ank_5, IQ, TIG$#ENSP00000354828#ENSG00000108509#ENST00000361571#CG-1#Ank_2, Ank_3, Ank_5, IQ, TIG$#ENSP00000370712#ENSG00000108509#ENST00000381311#CG-1#Ank_2, Ank_3, Ank_5, IQ, TIG$#ENSP00000412886#ENSG00000108509#ENST00000414043#CG-1#Ank_2, Ank_3, Ank_5, IQ, TIG FALSE 1062 ENSG00000153048 CARHSP1 CSD No ssDNA/RNA binding Not a DNA binding protein No motif None RNA-binding protein (PMID: 11842224; PMID: 21078874) IPR002059;IPR011129;IPR012340;IPR019844 23589 calcium regulated heat stable protein 1 [Source:HGNC Symbol;Acc:HGNC:17150] None not tested not tested None None c Yes No No 4a, two or more datasets predict it as a TF Sam Lambert Matt Weirauch No None $#ENSP00000311847#ENSG00000153048#ENST00000311052#Cold-shock protein, DNA-binding#$#ENSP00000379838#ENSG00000153048#ENST00000396593#Cold-shock protein, DNA-binding#$#ENSP00000460812#ENSG00000153048#ENST00000562843#Cold-shock protein, DNA-binding#$#ENSP00000455855#ENSG00000153048#ENST00000567554#Cold-shock protein, DNA-binding#$#ENSP00000455522#ENSG00000153048#ENST00000567908#Cold-shock protein, DNA-binding#$#ENSP00000455988#ENSG00000153048#ENST00000568968#Cold-shock protein, DNA-binding#DUF4339$#ENSP00000457213#ENSG00000153048#ENST00000569398#Cold-shock protein, DNA-binding#$#ENSP00000478055#ENSG00000153048#ENST00000610831#Cold-shock protein, DNA-binding#$#ENSP00000455284#ENSG00000153048#ENST00000561530#Cold-shock protein, DNA-binding#$#ENSP00000455016#ENSG00000153048#ENST00000565287#Cold-shock protein, DNA-binding#$#ENSP00000456909#ENSG00000153048#ENST00000568117#Cold-shock protein, DNA-binding#$#ENSP00000481550#ENSG00000153048#ENST00000611932#Cold-shock protein, DNA-binding#$#ENSP00000480144#ENSG00000153048#ENST00000619881#Cold-shock protein, DNA-binding# FALSE 1063 ENSG00000172346 CSDC2 CSD No ssDNA/RNA binding Not a DNA binding protein No motif None RNA-binding protein (PMID: 12801884) IPR002059;IPR011129;IPR012340;IPR019844 27254 cold shock domain containing C2 [Source:HGNC Symbol;Acc:HGNC:30359] None Full not tested None None x Yes No No 4a, two or more datasets predict it as a TF Pratyush Das Jussi Taipale No None $#ENSP00000302485#ENSG00000172346#ENST00000306149#Cold-shock protein, DNA-binding#$#ENSP00000417127#ENSG00000172346#ENST00000460790#Cold-shock protein, DNA-binding# FALSE 1064 ENSG00000009307 CSDE1 CSD No ssDNA/RNA binding Not a DNA binding protein No motif None Established RNA-binding protein. IPR002059;IPR011129;IPR012340;IPR019844;IPR024642; 7812 cold shock domain containing E1 [Source:HGNC Symbol;Acc:HGNC:29905] None not tested not tested None None x Yes No No 4a, two or more datasets predict it as a TF Tim Hughes Yimeng Yin No None $#ENSP00000261443#ENSG00000009307#ENST00000261443#Cold-shock protein, DNA-binding#SUZ-C$#ENSP00000342408#ENSG00000009307#ENST00000339438#Cold-shock protein, DNA-binding#SUZ-C$#ENSP00000351329#ENSG00000009307#ENST00000358528#Cold-shock protein, DNA-binding#SUZ-C$#ENSP00000358543#ENSG00000009307#ENST00000369530#Cold-shock protein, DNA-binding#SUZ-C$#ENSP00000407724#ENSG00000009307#ENST00000438362#Cold-shock protein, DNA-binding#SUZ-C$#ENSP00000432958#ENSG00000009307#ENST00000534699#Cold-shock protein, DNA-binding#SUZ-C FALSE 1065 ENSG00000131914 LIN28A CSD Yes Inferred motif Monomer or homomultimer High-throughput in vitro None Might also bind RNA IPR001878;IPR002059;IPR011129;IPR012340 79727 lin-28 homolog A [Source:HGNC Symbol;Acc:HGNC:15986] None not tested not tested None None x Yes No No 4a, two or more datasets predict it as a TF Pratyush Das Matt Weirauch No None $#ENSP00000254231#ENSG00000131914#ENST00000254231#Cold-shock protein, DNA-binding#zf-CCHC$#ENSP00000363314#ENSG00000131914#ENST00000326279#Cold-shock protein, DNA-binding#zf-CCHC FALSE 1066 ENSG00000187772 LIN28B CSD Yes Known motif Monomer or homomultimer High-throughput in vitro None Structure (PDB: 4A75) is with single stranded DNA. IPR001878;IPR002059;IPR011129;IPR012340 389421 lin-28 homolog B [Source:HGNC Symbol;Acc:HGNC:32207] 4A75 Full not tested None Structure is with single stranded DNA x Yes No No 1a1, Direct HQ evidence Pratyush Das Arttu Jolma No None $#ENSP00000344401#ENSG00000187772#ENST00000345080#Cold-shock protein, DNA-binding#zf-CCHC$#ENSP00000489735#ENSG00000187772#ENST00000635857#Cold-shock protein, DNA-binding#zf-CCHC$#ENSP00000490468#ENSG00000187772#ENST00000637759#Cold-shock protein, DNA-binding#zf-CCHC FALSE 1067 ENSG00000065978 YBX1 CSD Yes Known motif Monomer or homomultimer High-throughput in vitro None Might also bind RNA IPR002059;IPR011129;IPR012340;IPR019844 4904 Y-box binding protein 1 [Source:HGNC Symbol;Acc:HGNC:8014] None DBD not tested None None a Yes TF Gene_Single stranded RNA/DNA binding_TF PPI_PMIDS:15039105;15702969;1741293;15039105 Yes 1a1, Direct HQ evidence Matt Weirauch Yimeng Yin Yes $#ENSG00000065978#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:18809583$#ENSG00000065978#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:3174636 $#ENSP00000361626#ENSG00000065978#ENST00000321358#Cold-shock protein, DNA-binding#$#ENSP00000389639#ENSG00000065978#ENST00000436427#Cold-shock protein, DNA-binding#$#ENSP00000405937#ENSG00000065978#ENST00000332220#Cold-shock protein, DNA-binding# FALSE 1068 ENSG00000006047 YBX2 CSD Yes Inferred motif Monomer or homomultimer High-throughput in vitro None Might also bind RNA IPR002059;IPR011129;IPR012340;IPR019844 51087 Y-box binding protein 2 [Source:HGNC Symbol;Acc:HGNC:17948] None Full Yes None None x Yes No No 1a2, Orthologous HQ evidence Laura Campitelli Yimeng Yin Yes None $#ENSP00000007699#ENSG00000006047#ENST00000007699#Cold-shock protein, DNA-binding#$#ENSP00000459587#ENSG00000006047#ENST00000571464#Cold-shock protein, DNA-binding# FALSE 1069 ENSG00000060138 YBX3 CSD Yes Known motif Monomer or homomultimer 100 perc ID - in vitro None Identical DBD to YBX1. Might also bind RNA. IPR002059;IPR011129;IPR012340;IPR019844 8531 Y-box binding protein 3 [Source:HGNC Symbol;Acc:HGNC:2428] None DBD not tested None None a Yes Not a TF - Evidence that it is not a TF___PMIDS:0 Yes 1a2, Orthologous HQ evidence Jussi Taipale Sam Lambert Yes $#ENSG00000060138#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IEA - GO_REF:0000019$#ENSG00000060138#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:8710501 $#ENSP00000228251#ENSG00000060138#ENST00000228251#Cold-shock protein, DNA-binding#$#ENSP00000279550#ENSG00000060138#ENST00000279550#Cold-shock protein, DNA-binding#Herpes_LMP1$#ENSP00000485718#ENSG00000060138#ENST00000544622#Cold-shock protein, DNA-binding# FALSE 1070 ENSG00000168214 RBPJ CSL Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR002909;IPR008967;IPR014756;IPR015350;IPR015351; 3516 recombination signal binding protein for immunoglobulin kappa J region [Source:HGNC Symbol;Acc:HGNC: 2F8X DBD and Full Yes None RBPJ contacts DNA in the structure 2F8X, structure has also MAML1, but that does not contact the DNA a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:8152928;8625826 Yes 1a1, Direct HQ evidence Jussi Taipale Sam Lambert Yes $#ENSG00000168214#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:18663143$#ENSG00000168214#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:9874765 $#ENSP00000340124#ENSG00000168214#ENST00000342320#LAG1, DNA binding#BTD, TIG$#ENSP00000305815#ENSG00000168214#ENST00000345843#LAG1, DNA binding#BTD, TIG$#ENSP00000339699#ENSG00000168214#ENST00000348160#LAG1, DNA binding#BTD, TIG$#ENSP00000347659#ENSG00000168214#ENST00000355476#LAG1, DNA binding#BTD, TIG$#ENSP00000354528#ENSG00000168214#ENST00000361572#LAG1, DNA binding#BTD, TIG$#ENSP00000423907#ENSG00000168214#ENST00000507561#LAG1, DNA binding#BTD, TIG$#ENSP00000424804#ENSG00000168214#ENST00000509158#LAG1, DNA binding#$#ENSP00000423644#ENSG00000168214#ENST00000512671#LAG1, DNA binding#$#ENSP00000424459#ENSG00000168214#ENST00000504938#LAG1, DNA binding#$#ENSP00000424989#ENSG00000168214#ENST00000514807#LAG1, DNA binding# FALSE 1071 ENSG00000124232 RBPJL CSL Yes Inferred motif Monomer or homomultimer In vivo/Misc source None None IPR008967;IPR014756;IPR015350;IPR015351 11317 recombination signal binding protein for immunoglobulin kappa J region like [Source:HGNC Symbol;Acc: None DBD not tested None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:9111338;9111338;9111338;9111338;16354684 Yes 3a, decent circumstantial evidence for its role as Arttu Jolma Jussi Taipale Yes $#ENSG00000124232#GO:0000982#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000002$#ENSG00000124232#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:9929984 $#ENSP00000361826#ENSG00000124232#ENST00000372741#LAG1, DNA binding#BTD$#ENSP00000361828#ENSG00000124232#ENST00000372743#LAG1, DNA binding#BTD$#ENSP00000341243#ENSG00000124232#ENST00000343694#LAG1, DNA binding#BTD$#ENSP00000483978#ENSG00000124232#ENST00000464504#LAG1, DNA binding#BTD FALSE 1072 ENSG00000257923 CUX1 CUT; Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR003350;IPR009057;IPR010982;IPR012955;IPR017970 1523 cut like homeobox 1 [Source:HGNC Symbol;Acc:HGNC:2557] None DBD and Full not tested None None b Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:10864926;15994318 No 1a1, Direct HQ evidence Sam Lambert Pratyush Das Yes None $#ENSP00000292535#ENSG00000257923#ENST00000292535#CUT, Homeodomain#$#ENSP00000292538#ENSG00000257923#ENST00000292538#CUT, Homeodomain#CASP_C, DUF2205, NPV_P10$#ENSP00000353401#ENSG00000257923#ENST00000360264#CUT, Homeodomain#$#ENSP00000414091#ENSG00000257923#ENST00000437600#CUT, Homeodomain#CASP_C, DUF2205, NPV_P10$#ENSP00000484760#ENSG00000257923#ENST00000622516#CUT, Homeodomain#CASP_C, DUF2205, NPV_P10$#ENSP00000377410#ENSG00000257923#ENST00000393824#CUT, Homeodomain#CASP_C, DUF2205, NPV_P10$#ENSP00000409745#ENSG00000257923#ENST00000425244#CUT, Homeodomain#CASP_C, DUF2205, NPV_P10$#ENSP00000449371#ENSG00000257923#ENST00000547394#CUT, Homeodomain#CASP_C, DUF2205, NPV_P10 FALSE 1073 ENSG00000111249 CUX2 CUT; Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR003350;IPR009057;IPR010982;IPR017970; 23316 cut like homeobox 2 [Source:HGNC Symbol;Acc:HGNC:19347] None DBD not tested None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:8798433;15656993 No 1a1, Direct HQ evidence Tim Hughes Yimeng Yin Yes $#ENSG00000111249#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019 $#ENSP00000261726#ENSG00000111249#ENST00000261726#CUT, Homeodomain#DUF4618$#ENSP00000380765#ENSG00000111249#ENST00000397643#CUT, Homeodomain# FALSE 1074 ENSG00000169856 ONECUT1 CUT; Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR003350;IPR009057;IPR010982 3175 one cut homeobox 1 [Source:HGNC Symbol;Acc:HGNC:8138] 2D5V DBD and Full not tested None The structure has both the CUT and homeodomain a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:15581617;16618419 Yes 1a1, Direct HQ evidence Jussi Taipale Laura Campitelli Yes $#ENSG00000169856#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IBA - GO_REF:0000033 | ISS - GO_REF:0000024 $#ENSP00000302630#ENSG00000169856#ENST00000305901#CUT, Homeodomain#$#ENSP00000453718#ENSG00000169856#ENST00000560699#CUT, Homeodomain# FALSE 1075 ENSG00000119547 ONECUT2 CUT; Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR003350;IPR009057;IPR010982 9480 one cut homeobox 2 [Source:HGNC Symbol;Acc:HGNC:8139] None DBD and Full not tested None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:9915796 Yes 1a1, Direct HQ evidence Pratyush Das Jussi Taipale Yes $#ENSG00000119547#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:11478782 $#ENSP00000419185#ENSG00000119547#ENST00000491143#CUT, Homeodomain# FALSE 1076 ENSG00000205922 ONECUT3 CUT; Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR003350;IPR009057;IPR010982 390874 one cut homeobox 3 [Source:HGNC Symbol;Acc:HGNC:13399] None DBD not tested None None b Yes TF Gene Candidate_DNA-Binding: sequence-specific; Transcription Regulatory Activity: heterochromatin interaction/binding_DNA Binding; Transactivation_PMIDS:11944891;11944891 Yes 1a1, Direct HQ evidence Arttu Jolma Pratyush Das Yes $#ENSG00000205922#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IBA - GO_REF:0000033 $#ENSP00000371786#ENSG00000205922#ENST00000382349#CUT, Homeodomain# FALSE 1077 ENSG00000182568 SATB1 CUT; Homeodomain Yes Known motif Low specificity DNA-binding protein In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain SATBs were analyzed by Gwenael Badis and Mike Berger a decade ago; by PBMs. It did not yield a motif; instead; the signal was very closely proportional to nucleotide content, as the name suggests (Special AT Binding). IPR001356;IPR003350;IPR009057;IPR010982 6304 SATB homeobox 1 [Source:HGNC Symbol;Acc:HGNC:10541] 2O49 DBD and Full not tested None Structure has only the CUT-domain of the protein a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:1505028;8114718;9340009 Yes 1a1, Direct HQ evidence Arttu Jolma Jussi Taipale Yes $#ENSG00000182568#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IDA - PMID:15851481 $#ENSP00000341024#ENSG00000182568#ENST00000338745#CUT, Homeodomain#CUTL, ULD$#ENSP00000399518#ENSG00000182568#ENST00000417717#CUT, Homeodomain#CUTL, SUIM_assoc, ULD$#ENSP00000399708#ENSG00000182568#ENST00000454909#CUT, Homeodomain#CUTL, ULD$#ENSP00000479866#ENSG00000182568#ENST00000491519#CUT, Homeodomain#CUTL, RuvA_C, ULD$#ENSP00000408871#ENSG00000182568#ENST00000414509#CUT, Homeodomain#ULD$#ENSP00000390529#ENSG00000182568#ENST00000415069#CUT, Homeodomain#ULD$#ENSP00000453908#ENSG00000182568#ENST00000493952#CUT, Homeodomain# FALSE 1078 ENSG00000119042 SATB2 CUT; Homeodomain Yes Inferred motif Low specificity DNA-binding protein In vivo/Misc source None SATBs were analyzed by Gwenael Badis and Mike Berger a decade ago; by PBMs. It did not yield a motif; instead; the signal was very closely proportional to nucleotide content, as the name suggests (Special AT Binding). IPR001356;IPR003350;IPR009057;IPR010982 23314 SATB homeobox 2 [Source:HGNC Symbol;Acc:HGNC:21637] None DBD and Full not tested None None a Yes TF Gene Candidate_DNA-Binding: sequence-specific_DNA Binding_PMIDS:14701874 No 2a2, orthologous lower confidence evidence Laura Campitelli Tim Hughes Yes None $#ENSP00000260926#ENSG00000119042#ENST00000260926#CUT, Homeodomain#CUTL, ULD$#ENSP00000388581#ENSG00000119042#ENST00000428695#CUT, Homeodomain#ULD$#ENSP00000401112#ENSG00000119042#ENST00000417098#CUT, Homeodomain#CUTL, ULD$#ENSP00000405420#ENSG00000119042#ENST00000457245#CUT, Homeodomain#CUTL, ULD FALSE 1079 ENSG00000154832 CXXC1 CxxC Yes Known motif Monomer or homomultimer High-throughput in vitro None X-ray structure (PDB:3QMI) indicates sequence specific binding through base contacts (PMID: 21407193). IPR001965;IPR002857;IPR011011;IPR019786;IPR019787;IPR022056 30827 CXXC finger protein 1 [Source:HGNC Symbol;Acc:HGNC:24343] 3QMI not tested not tested None Structure has many contacts between the AA-residues and the DNA-bases in the major groove, could well be sequence-specific other Yes No No 1a1, Direct HQ evidence Sam Lambert Arttu Jolma Yes None $#ENSP00000285106#ENSG00000154832#ENST00000285106#CxxC#PHD, zf-CpG_bind_C$#ENSP00000390475#ENSG00000154832#ENST00000412036#CxxC#PHD, zf-CpG_bind_C$#ENSP00000467634#ENSG00000154832#ENST00000589940#CxxC#PHD, zf-CpG_bind_C$#ENSP00000468038#ENSG00000154832#ENST00000589548#CxxC#PHD, PHD_2$#ENSP00000465849#ENSG00000154832#ENST00000591474#CxxC# FALSE 1080 ENSG00000168772 CXXC4 CxxC Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Binds unmethylated CpG-rich sequences: (PMID: 23563267). IPR002857; 80319 CXXC finger protein 4 [Source:HGNC Symbol;Acc:HGNC:24593] None not tested not tested None None No Yes No No 5a, one of the source datasets predicts is as a TF Matt Weirauch Arttu Jolma No None $#ENSP00000378248#ENSG00000168772#ENST00000394767#CxxC# FALSE 1081 ENSG00000171604 CXXC5 CxxC Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR002857; 51523 CXXC finger protein 5 [Source:HGNC Symbol;Acc:HGNC:26943] None not tested Yes None TFs that are in CisBP but not in Vaquerizas set No Yes No No 1a1, Direct HQ evidence Sam Lambert Laura Campitelli No None $#ENSP00000302543#ENSG00000171604#ENST00000302517#CxxC#$#ENSP00000424219#ENSG00000171604#ENST00000502716#CxxC#$#ENSP00000421057#ENSG00000171604#ENST00000503511#CxxC#$#ENSP00000425203#ENSG00000171604#ENST00000504844#CxxC#$#ENSP00000427440#ENSG00000171604#ENST00000509238#CxxC#$#ENSP00000427379#ENSG00000171604#ENST00000511048#CxxC#$#ENSP00000422883#ENSG00000171604#ENST00000504944#CxxC#$#ENSP00000430949#ENSG00000171604#ENST00000511457#CxxC#$#ENSP00000421866#ENSG00000171604#ENST00000511591#CxxC#$#ENSP00000423365#ENSG00000171604#ENST00000512816#CxxC#$#ENSP00000430522#ENSG00000171604#ENST00000520967#CxxC# FALSE 1082 ENSG00000130816 DNMT1 CxxC Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001025;IPR001525;IPR002857;IPR010506;IPR017198;IPR018117;IPR022702;IPR029063 1786 DNA (cytosine-5-)-methyltransferase 1 [Source:HGNC Symbol;Acc:HGNC:2976] 4DA4 not tested Yes None TFs that are in CisBP but not in Vaquerizas set No Yes No No 1a1, Direct HQ evidence Jussi Taipale Laura Campitelli Yes None $#ENSP00000345739#ENSG00000130816#ENST00000340748#CxxC#BAH, DMAP_binding, DNA_methylase, DNMT1-RFD$#ENSP00000352516#ENSG00000130816#ENST00000359526#CxxC#BAH, DMAP_binding, DNA_methylase, DNMT1-RFD$#ENSP00000468062#ENSG00000130816#ENST00000590619#CxxC#$#ENSP00000465555#ENSG00000130816#ENST00000586800#CxxC#$#ENSP00000465993#ENSG00000130816#ENST00000592342#CxxC# FALSE 1083 ENSG00000099364 FBXL19 CxxC Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR001611;IPR001810;IPR001965;IPR002857;IPR006553;IPR011011;IPR019786;IPR019787 54620 F-box and leucine rich repeat protein 19 [Source:HGNC Symbol;Acc:HGNC:25300] None not tested Yes None None No Yes No No 5a, one of the source datasets predicts is as a TF Yimeng Yin Tim Hughes No None $#ENSP00000397913#ENSG00000099364#ENST00000427128#CxxC#F-box, F-box-like, LRR_4, LRR_6, LRR_8, PHD, PHD_4$#ENSP00000369666#ENSG00000099364#ENST00000380310#CxxC#F-box, F-box-like, LRR_4, LRR_6, LRR_8, PHD, PHD_4$#ENSP00000458033#ENSG00000099364#ENST00000471231#CxxC#F-box, F-box-like, LRR_1, LRR_4, LRR_6, LRR_8$#ENSP00000455529#ENSG00000099364#ENST00000562319#CxxC#F-box, F-box-like, LRR_4, LRR_6, LRR_8, PHD, PHD_4$#ENSP00000457199#ENSG00000099364#ENST00000565939#CxxC# FALSE 1084 ENSG00000173120 KDM2A CxxC Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Has a CXXC zinc finger that recognizes CGs (PMID: 22083960) IPR001810;IPR001965;IPR002857;IPR003347;IPR006553;IPR011011;IPR019786;IPR019787 22992 lysine demethylase 2A [Source:HGNC Symbol;Acc:HGNC:13606] None not tested not tested Chromatin_Modifier_etc Lysine-specific demethylase 2A No Yes No No 5a, one of the source datasets predicts is as a TF Matt Weirauch Pratyush Das Yes None $#ENSP00000309302#ENSG00000173120#ENST00000308783#CxxC#Cupin_8, F-box, F-box-like, JmjC, LRR_6, PHD_4$#ENSP00000381640#ENSG00000173120#ENST00000398645#CxxC#Cupin_8, JmjC, PHD_4$#ENSP00000432786#ENSG00000173120#ENST00000529006#CxxC#Cupin_8, F-box, F-box-like, JmjC, LRR_6, PHD_4$#ENSP00000435776#ENSG00000173120#ENST00000530342#CxxC#F-box, F-box-like, LRR_6, PHD_4 FALSE 1085 ENSG00000089094 KDM2B CxxC Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001810;IPR001965;IPR002857;IPR003347;IPR006553;IPR011011;IPR019787; 102465665 lysine demethylase 2B [Source:HGNC Symbol;Acc:HGNC:13610] None not tested Yes None TFs that are in CisBP but not in Vaquerizas set No Yes No No 1a1, Direct HQ evidence Arttu Jolma Jussi Taipale No None $#ENSP00000366271#ENSG00000089094#ENST00000377071#CxxC#Cupin_8, F-box, F-box-like, JmjC, PHD, PHD_4$#ENSP00000445196#ENSG00000089094#ENST00000536437#CxxC#Cupin_8, JmjC, PHD_4$#ENSP00000474307#ENSG00000089094#ENST00000538046#CxxC#$#ENSP00000366269#ENSG00000089094#ENST00000377069#CxxC#Cupin_8, F-box, F-box-like, JmjC, PHD, PHD_4$#ENSP00000437821#ENSG00000089094#ENST00000542973#CxxC#F-box, F-box-like, LRR_6, LRR_8, PHD, PHD_4 FALSE 1086 ENSG00000138336 TET1 CxxC Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR002857;IPR024779 80312 tet methylcytosine dioxygenase 1 [Source:HGNC Symbol;Acc:HGNC:29484] None not tested Yes None TFs that are in CisBP but not in Vaquerizas set No Yes No No 1a1, Direct HQ evidence Matt Weirauch Jussi Taipale Yes None $#ENSP00000362748#ENSG00000138336#ENST00000373644#CxxC#Tet_JBP FALSE 1087 ENSG00000187605 TET3 CxxC Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR002857;IPR024779 200424 tet methylcytosine dioxygenase 3 [Source:HGNC Symbol;Acc:HGNC:28313] 4HP1 not tested not tested None None No Yes No No 3a, decent circumstantial evidence for its role as Jussi Taipale Pratyush Das No None $#ENSP00000386869#ENSG00000187605#ENST00000409262#CxxC#Tet_JBP$#ENSP00000307803#ENSG00000187605#ENST00000305799#CxxC#Tet_JBP FALSE 1088 ENSG00000118058 KMT2A CxxC; AT hook Yes Known motif Monomer or homomultimer High-throughput in vitro None Contains 3 AT-hook domain, a CXXC domain, and a possible C2H2 domain. IPR001214;IPR001487;IPR001965;IPR002857;IPR003616;IPR003888;IPR003889;IPR011011;IPR016569;IPR019787 4297 lysine methyltransferase 2A [Source:HGNC Symbol;Acc:HGNC:7132] None not tested Yes None None c Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:12453418 Yes 1a1, Direct HQ evidence Yimeng Yin Pratyush Das Yes $#ENSG00000118058#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:10821850 $#ENSP00000374157#ENSG00000118058#ENST00000389506#CxxC#Bromodomain, FYRC, FYRN, PHD, PHD_2, SET, zf-HC5HC$#ENSP00000376612#ENSG00000118058#ENST00000392873#CxxC#PHD, PHD_2, PHD_4, zf-PHD-like$#ENSP00000436786#ENSG00000118058#ENST00000534358#CxxC#Bromodomain, FYRC, FYRN, PHD, PHD_2, SET, zf-HC5HC$#ENSP00000436564#ENSG00000118058#ENST00000529852#CxxC#$#ENSP00000432391#ENSG00000118058#ENST00000531904#CxxC#$#ENSP00000434618#ENSG00000118058#ENST00000532204#CxxC#$#ENSP00000436700#ENSG00000118058#ENST00000533790#CxxC#$#ENSP00000432652#ENSG00000118058#ENST00000527869#CxxC# FALSE 1089 ENSG00000272333 KMT2B CxxC; AT hook Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Structural evidence shows direct DNA-binding (PDB:4PZI) and KMT2B appears to make specific contacts with methylated DNA. IPR001214;IPR001965;IPR002857;IPR003616;IPR003888;IPR003889;IPR011011;IPR016569;IPR019787 9757 lysine methyltransferase 2B [Source:HGNC Symbol;Acc:HGNC:15840] 4PZI not tested not tested None Protein contacts the DNA, could well be sequence specific No Yes No Yes 1a1, Direct HQ evidence Sam Lambert Laura Campitelli Yes $#ENSG00000272333#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:10409430 $#ENSP00000398837#ENSG00000272333#ENST00000420124#CxxC#FYRC, FYRN, PHD, SET, zf-HC5HC2H, zf-HC5HC2H_2 FALSE 1090 ENSG00000137090 DMRT1 DM Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001275;IPR022114 1761 doublesex and mab-3 related transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:2934] 4YJ0 DBD and Full Yes None None a Yes Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0 Yes 1a1, Direct HQ evidence Jussi Taipale Arttu Jolma Yes $#ENSG00000137090#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IEA - GO_REF:0000019$#ENSG00000137090#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000371711#ENSG00000137090#ENST00000382276#DM#Dmrt1$#ENSP00000454701#ENSG00000137090#ENST00000569227#DM#Dmrt1 FALSE 1091 ENSG00000173253 DMRT2 DM Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001275; 10655 doublesex and mab-3 related transcription factor 2 [Source:HGNC Symbol;Acc:HGNC:2935] None DBD Yes None None a Yes Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0 Yes 1a1, Direct HQ evidence Sam Lambert Arttu Jolma Yes $#ENSG00000173253#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000350865#ENSG00000173253#ENST00000358146#DM#$#ENSP00000371690#ENSG00000173253#ENST00000382255#DM#$#ENSP00000397494#ENSG00000173253#ENST00000412350#DM#$#ENSP00000259622#ENSG00000173253#ENST00000259622#DM# FALSE 1092 ENSG00000064218 DMRT3 DM Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001275;IPR005173;IPR009060; 58524 doublesex and mab-3 related transcription factor 3 [Source:HGNC Symbol;Acc:HGNC:13909] None DBD and Full Yes None None a Yes Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0 Yes 1a1, Direct HQ evidence Matt Weirauch Yimeng Yin Yes $#ENSG00000064218#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000190165#ENSG00000064218#ENST00000190165#DM#DMA$#ENSP00000387472#ENSG00000064218#ENST00000417254#DM# FALSE 1093 ENSG00000176399 DMRTA1 DM Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001275;IPR005173;IPR009060; 63951 DMRT like family A1 [Source:HGNC Symbol;Acc:HGNC:13826] None DBD and Full not tested None None b Yes No Yes 1a1, Direct HQ evidence Pratyush Das Arttu Jolma Yes $#ENSG00000176399#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000319651#ENSG00000176399#ENST00000325870#DM#DMA FALSE 1094 ENSG00000142700 DMRTA2 DM Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001275;IPR005173;IPR009060; 63950 DMRT like family A2 [Source:HGNC Symbol;Acc:HGNC:13908] None DBD Yes None None b Yes No Yes 1a1, Direct HQ evidence Pratyush Das Laura Campitelli Yes $#ENSG00000142700#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000399370#ENSG00000142700#ENST00000418121#DM#DMA$#ENSP00000383909#ENSG00000142700#ENST00000404795#DM#DMA FALSE 1095 ENSG00000143006 DMRTB1 DM Yes Likely to be sequence specific TF Obligate heteromer No motif None None IPR001275; 63948 DMRT like family B with proline rich C-terminal 1 [Source:HGNC Symbol;Acc:HGNC:13913] None DBD and Full not tested None None b Yes No Yes 4a, two or more datasets predict it as a TF Pratyush Das Jussi Taipale Yes $#ENSG00000143006#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000360500#ENSG00000143006#ENST00000371445#DM# FALSE 1096 ENSG00000142025 DMRTC2 DM Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001275; 63946 DMRT like family C2 [Source:HGNC Symbol;Acc:HGNC:13911] None DBD and Full Yes None None b Yes Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0 Yes 1a1, Direct HQ evidence Sam Lambert Pratyush Das Yes $#ENSG00000142025#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000269945#ENSG00000142025#ENST00000269945#DM#DMRT-like$#ENSP00000469525#ENSG00000142025#ENST00000596827#DM#DMRT-like FALSE 1097 ENSG00000101412 E2F1 E2F Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR003316; 1869 E2F transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:3113] None DBD and Full Yes None Prefers heterodimer with TFDP proteins over homodimer a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:16741925;17178835 Yes 1a1, Direct HQ evidence Yimeng Yin Sam Lambert Yes $#ENSG00000101412#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:15731768 | TAS - PMID:11418595 $#ENSP00000345571#ENSG00000101412#ENST00000343380#E2F#E2F_CC-MB FALSE 1098 ENSG00000007968 E2F2 E2F Yes Known motif Monomer or homomultimer High-throughput in vitro None Can also bind as a heterodimer with DP1 (PMID: 16360038) IPR003316; 1870 E2F transcription factor 2 [Source:HGNC Symbol;Acc:HGNC:3114] None DBD and Full Yes None Prefers heterodimer with TFDP proteins over homodimer a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:10766737;11883935 Yes 1a1, Direct HQ evidence Laura Campitelli Arttu Jolma Yes $#ENSG00000007968#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019 $#ENSP00000355249#ENSG00000007968#ENST00000361729#E2F#E2F_CC-MB FALSE 1099 ENSG00000112242 E2F3 E2F Yes Known motif Monomer or homomultimer High-throughput in vitro None Binds preferentially with DP proteins in vivo IPR003316; 1871 E2F transcription factor 3 [Source:HGNC Symbol;Acc:HGNC:3115] None DBD and Full Yes None Prefers heterodimer with TFDP proteins over homodimer a Yes TF Gene Candidate_DNA-Binding: sequence-specific_Co-activation_PMIDS:15448153;17135268 Yes 1a1, Direct HQ evidence Sam Lambert Jussi Taipale Yes $#ENSG00000112242#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019 $#ENSP00000262904#ENSG00000112242#ENST00000346618#E2F#E2F_CC-MB$#ENSP00000443418#ENSG00000112242#ENST00000535432#E2F#E2F_CC-MB$#ENSP00000483249#ENSG00000112242#ENST00000613242#E2F# FALSE 1100 ENSG00000205250 E2F4 E2F Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR003316; 1874 E2F transcription factor 4 [Source:HGNC Symbol;Acc:HGNC:3118] 1CF7 DBD Yes None Prefers heterodimer with TFDP proteins over homodimer a Yes TF Gene_DNA-Binding: sequence-specific; Transcription Factor Binding: tf co-factor binding_DNA Binding; Transactivation_PMIDS:12110166 Yes 1a1, Direct HQ evidence Pratyush Das Sam Lambert Yes $#ENSG00000205250#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IC - GO_REF:0000036$#ENSG00000205250#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:11418595 $#ENSP00000368686#ENSG00000205250#ENST00000379378#E2F#E2F_CC-MB$#ENSP00000458706#ENSG00000205250#ENST00000565226#E2F# FALSE 1101 ENSG00000133740 E2F5 E2F Yes Known motif Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain Also heterodimerzes with DP2 (PMID: 7760804) IPR003316; 1875 E2F transcription factor 5 [Source:HGNC Symbol;Acc:HGNC:3119] None DBD Yes None None a Yes TF Gene Candidate_DNA-Binding: sequence-specific_DNA Binding; Other_PMIDS:7760804 Yes 2a1, Lower confidence direct evidence Matt Weirauch Sam Lambert Yes $#ENSG00000133740#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019 $#ENSP00000398124#ENSG00000133740#ENST00000416274#E2F#E2F_CC-MB$#ENSP00000414312#ENSG00000133740#ENST00000418930#E2F#E2F_CC-MB$#ENSP00000429120#ENSG00000133740#ENST00000517476#E2F#E2F_CC-MB$#ENSP00000430461#ENSG00000133740#ENST00000520225#E2F# FALSE 1102 ENSG00000169016 E2F6 E2F Yes Known motif Monomer or homomultimer In vivo/Misc source None None IPR003316; 1876 E2F transcription factor 6 [Source:HGNC Symbol;Acc:HGNC:3120] None DBD Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:15574595;15936277 No 1a1, Direct HQ evidence Laura Campitelli Pratyush Das Yes $#ENSG00000169016#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019 $#ENSP00000302159#ENSG00000169016#ENST00000307236#E2F#E2F_CC-MB$#ENSP00000370936#ENSG00000169016#ENST00000381525#E2F#E2F_CC-MB$#ENSP00000446315#ENSG00000169016#ENST00000542100#E2F#E2F_CC-MB$#ENSP00000438864#ENSG00000169016#ENST00000546212#E2F#E2F_CC-MB FALSE 1103 ENSG00000165891 E2F7 E2F Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR003316; 144455 E2F transcription factor 7 [Source:HGNC Symbol;Acc:HGNC:23820] None DBD and Full not tested None None c Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:12893818;14633988 Yes 1a1, Direct HQ evidence Arttu Jolma Yimeng Yin Yes $#ENSG00000165891#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IEA - GO_REF:0000019$#ENSG00000165891#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:22802528 | IMP - PMID:22903062 $#ENSP00000323246#ENSG00000165891#ENST00000322886#E2F#$#ENSP00000448245#ENSG00000165891#ENST00000550669#E2F#$#ENSP00000449284#ENSG00000165891#ENST00000551058#E2F#$#ENSP00000449033#ENSG00000165891#ENST00000547316#E2F# FALSE 1104 ENSG00000129173 E2F8 E2F Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR003316; 79733 E2F transcription factor 8 [Source:HGNC Symbol;Acc:HGNC:24727] 4YO2 DBD and Full not tested None None c Yes No Yes 1a1, Direct HQ evidence Pratyush Das Tim Hughes Yes $#ENSG00000129173#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:16179649$#ENSG00000129173#GO:0003700#sequence-specific DNA binding transcription factor activity#IMP - PMID:22903062 $#ENSP00000250024#ENSG00000129173#ENST00000250024#E2F#$#ENSP00000437326#ENSG00000129173#ENST00000532666#E2F#$#ENSP00000434199#ENSG00000129173#ENST00000527884#E2F#$#ENSP00000481103#ENSG00000129173#ENST00000620009#E2F# FALSE 1105 ENSG00000198176 TFDP1 E2F Yes Known motif Obligate heteromer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain None IPR003316;IPR014889;IPR015648; 7027 transcription factor Dp-1 [Source:HGNC Symbol;Acc:HGNC:11749] None DBD and Full Yes Obligate_Multimer Well established to make heterodimers with E2F-TFs a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:8446173 Yes 2a1, Lower confidence direct evidence Yimeng Yin Pratyush Das Yes $#ENSG00000198176#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000198176#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:8405995 $#ENSP00000364519#ENSG00000198176#ENST00000375370#E2F#$#ENSP00000401389#ENSG00000198176#ENST00000453989#E2F#$#ENSP00000386145#ENSG00000198176#ENST00000408980#E2F# FALSE 1106 ENSG00000114126 TFDP2 E2F Yes Inferred motif Obligate heteromer In vivo/Misc source None None IPR003316;IPR014889;IPR015648; 7029 transcription factor Dp-2 [Source:HGNC Symbol;Acc:HGNC:11751] 1CF7 DBD and Full not tested Obligate_Multimer The structure is E2F4 - TFDP2 heterodimer; compulsory heterodimer with E2F-proteins a Yes TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_TF PPI; Transactivation_PMIDS:7478568;7784053;10090723 Yes 2a1, Lower confidence direct evidence Pratyush Das Sam Lambert Yes $#ENSG00000114126#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000114126#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:7784053 $#ENSP00000418590#ENSG00000114126#ENST00000467072#E2F#$#ENSP00000417585#ENSG00000114126#ENST00000479040#E2F#$#ENSP00000420599#ENSG00000114126#ENST00000486111#E2F#$#ENSP00000420616#ENSG00000114126#ENST00000489671#E2F#$#ENSP00000420657#ENSG00000114126#ENST00000494358#E2F#$#ENSP00000439782#ENSG00000114126#ENST00000499676#E2F#$#ENSP00000419507#ENSG00000114126#ENST00000474279#E2F#$#ENSP00000418971#ENSG00000114126#ENST00000477292#E2F#$#ENSP00000419036#ENSG00000114126#ENST00000495310#E2F#$#ENSP00000417726#ENSG00000114126#ENST00000467667#E2F#$#ENSP00000418122#ENSG00000114126#ENST00000478006#E2F#$#ENSP00000417220#ENSG00000114126#ENST00000497579#E2F# FALSE 1107 ENSG00000183434 TFDP3 E2F Yes Inferred motif Obligate heteromer In vivo/Misc source None Interacts with E2F1; E2F2; E2F3; E2F4 and E2F5 (PMID: 17062573). IPR003316;IPR014889;IPR015648; 51270 transcription factor Dp family member 3 [Source:HGNC Symbol;Acc:HGNC:24603] None DBD and Full not tested None Heterodimerizes with E2F proteins b Yes No Yes 2a2, orthologous lower confidence evidence Sam Lambert Arttu Jolma No $#ENSG00000183434#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000385461#ENSG00000183434#ENST00000310125#E2F# FALSE 1108 ENSG00000164330 EBF1 EBF1 Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR002909;IPR014756;IPR018350; 1879 early B-cell factor 1 [Source:HGNC Symbol;Acc:HGNC:3126] 3MLN DBD and Full Yes None None a Yes TF Gene Candidate_DNA-Binding: non-sequence-specific_Non-specific DNA_PMIDS:12446773 Yes 1a1, Direct HQ evidence Sam Lambert Yimeng Yin Yes $#ENSG00000164330#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IBA - GO_REF:0000033 $#ENSP00000322898#ENSG00000164330#ENST00000313708#COE1 DBD#COE1_HLH, TIG$#ENSP00000370029#ENSG00000164330#ENST00000380654#COE1 DBD#COE1_HLH, TIG$#ENSP00000428020#ENSG00000164330#ENST00000517373#COE1 DBD#COE1_HLH, TIG$#ENSP00000477809#ENSG00000164330#ENST00000622875#COE1 DBD#COE1_HLH, TIG FALSE 1109 ENSG00000221818 EBF2 EBF1 Yes Known motif Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain EBF1 has a nice HT-SELEX model and based on this paper (PMID:23499423). EBF2 binds similar motif to control brown/beige fat cell identity. IPR002909;IPR014756;IPR018350; 64641 early B-cell factor 2 [Source:HGNC Symbol;Acc:HGNC:19090] None DBD Yes None EBF1 has a nice HT-SELEX model and based on this paper PMID:23499423 EBF2 binds similar motif to control brown/beige fat cell identity b Yes No Yes 2a1, Lower confidence direct evidence Jussi Taipale Arttu Jolma Yes $#ENSG00000221818#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IBA - GO_REF:0000033 $#ENSP00000386178#ENSG00000221818#ENST00000408929#COE1 DBD#COE1_HLH, TIG$#ENSP00000430241#ENSG00000221818#ENST00000520164#COE1 DBD#COE1_HLH, TIG$#ENSP00000437909#ENSG00000221818#ENST00000535548#COE1 DBD#COE1_HLH FALSE 1110 ENSG00000108001 EBF3 EBF1 Yes Known motif Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain None IPR002909;IPR014756;IPR018350; 253738 early B-cell factor 3 [Source:HGNC Symbol;Acc:HGNC:19087] None DBD and Full Yes None EBF1 has a nice HT-SELEX model and based on this paper PMID:23499423 EBF2 binds similar motif to control brown/beige fat cell identity a Yes No Yes 2a1, Lower confidence direct evidence Matt Weirauch Yimeng Yin Yes $#ENSG00000108001#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IBA - GO_REF:0000033 $#ENSP00000357637#ENSG00000108001#ENST00000368648#COE1 DBD#COE1_HLH, TIG$#ENSP00000387543#ENSG00000108001#ENST00000440978#COE1 DBD#$#ENSP00000347463#ENSG00000108001#ENST00000355311#COE1 DBD#COE1_HLH, TIG FALSE 1111 ENSG00000088881 EBF4 EBF1 Yes Known motif Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain None IPR002909;IPR014756;IPR018350; 57593 early B-cell factor 4 [Source:HGNC Symbol;Acc:HGNC:29278] None DBD and Full Yes None EBF1 has a nice HT-SELEX model and based on this paper PMID:23499423 EBF2 binds similar motif to control brown/beige fat cell identity b Yes No Yes 2a1, Lower confidence direct evidence Jussi Taipale Laura Campitelli Yes $#ENSG00000088881#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IBA - GO_REF:0000033 $#ENSP00000345030#ENSG00000088881#ENST00000342725#COE1 DBD#COE1_HLH, TIG$#ENSP00000370022#ENSG00000088881#ENST00000380648#COE1 DBD#COE1_HLH, TIG$#ENSP00000477107#ENSG00000088881#ENST00000463145#COE1 DBD#$#ENSP00000477023#ENSG00000088881#ENST00000609451#COE1 DBD#COE1_HLH, TIG FALSE 1112 ENSG00000135373 EHF Ets Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000418;IPR003118;IPR013761; 26298 ETS homologous factor [Source:HGNC Symbol;Acc:HGNC:3246] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:10644770;17027647 Yes 1a1, Direct HQ evidence Pratyush Das Jussi Taipale Yes $#ENSG00000135373#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:17027647$#ENSG00000135373#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:10644770 $#ENSP00000257831#ENSG00000135373#ENST00000257831#ETS#SAM_PNT$#ENSP00000399733#ENSG00000135373#ENST00000450654#ETS#SAM_PNT$#ENSP00000433508#ENSG00000135373#ENST00000530286#ETS#SAM_PNT$#ENSP00000435835#ENSG00000135373#ENST00000531794#ETS#SAM_PNT$#ENSP00000435837#ENSG00000135373#ENST00000533754#ETS#SAM_PNT$#ENSP00000436158#ENSG00000135373#ENST00000527935#ETS#SAM_PNT$#ENSP00000436357#ENSG00000135373#ENST00000531728#ETS#SAM_PNT FALSE 1113 ENSG00000120690 ELF1 Ets Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000418;IPR022084 1997 E74 like ETS transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:3316] None DBD and Full not tested None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; TF PPI_PMIDS:12065417;16002702 Yes 1a1, Direct HQ evidence Yimeng Yin Sam Lambert Yes $#ENSG00000120690#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:8756667$#ENSG00000120690#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:14970218 $#ENSP00000239882#ENSG00000120690#ENST00000239882#ETS#Elf-1_N$#ENSP00000405580#ENSG00000120690#ENST00000442101#ETS#$#ENSP00000384135#ENSG00000120690#ENST00000405737#ETS#Elf-1_N$#ENSP00000486912#ENSG00000120690#ENST00000625359#ETS#Elf-1_N FALSE 1114 ENSG00000109381 ELF2 Ets Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000418;IPR022084 1998 E74 like ETS transcription factor 2 [Source:HGNC Symbol;Acc:HGNC:3317] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:8756667 Yes 1a1, Direct HQ evidence Tim Hughes Arttu Jolma Yes $#ENSG00000109381#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000351458#ENSG00000109381#ENST00000358635#ETS#Elf-1_N$#ENSP00000397796#ENSG00000109381#ENST00000420916#ETS#Elf-1_N$#ENSP00000426997#ENSG00000109381#ENST00000510408#ETS#Elf-1_N$#ENSP00000368867#ENSG00000109381#ENST00000379549#ETS#Elf-1_N$#ENSP00000426087#ENSG00000109381#ENST00000512627#ETS#Elf-1_N FALSE 1115 ENSG00000102034 ELF4 Ets Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000418;IPR022084 2000 E74 like ETS transcription factor 4 [Source:HGNC Symbol;Acc:HGNC:3319] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:8895518 Yes 1a1, Direct HQ evidence Matt Weirauch Arttu Jolma Yes $#ENSG00000102034#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:14625302 $#ENSP00000311280#ENSG00000102034#ENST00000308167#ETS#Elf-1_N$#ENSP00000338608#ENSG00000102034#ENST00000335997#ETS#Elf-1_N$#ENSP00000407572#ENSG00000102034#ENST00000434609#ETS#Elf-1_N$#ENSP00000478297#ENSG00000102034#ENST00000615377#ETS#Elf-1_N FALSE 1116 ENSG00000135374 ELF5 Ets Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000418;IPR003118;IPR013761; 2001 E74 like ETS transcription factor 5 [Source:HGNC Symbol;Acc:HGNC:3320] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:9840936;10506207 Yes 1a1, Direct HQ evidence Sam Lambert Tim Hughes Yes $#ENSG00000135374#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000135374#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IEA - GO_REF:0000019 $#ENSP00000257832#ENSG00000135374#ENST00000257832#ETS#SAM_PNT$#ENSP00000311010#ENSG00000135374#ENST00000312319#ETS#SAM_PNT$#ENSP00000407589#ENSG00000135374#ENST00000429939#ETS#$#ENSP00000436386#ENSG00000135374#ENST00000532417#ETS#SAM_PNT FALSE 1117 ENSG00000126767 ELK1 Ets Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000418; 2002 ELK1, ETS transcription factor [Source:HGNC Symbol;Acc:HGNC:3321] 1DUX DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_Transactivation_PMIDS:11151091;15808854 Yes 1a1, Direct HQ evidence Laura Campitelli Matt Weirauch Yes $#ENSG00000126767#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:12750007$#ENSG00000126767#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:14970218 $#ENSP00000247161#ENSG00000126767#ENST00000247161#ETS#$#ENSP00000345585#ENSG00000126767#ENST00000343894#ETS#$#ENSP00000366182#ENSG00000126767#ENST00000376983#ETS# FALSE 1118 ENSG00000111145 ELK3 Ets Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000418; 2004 ELK3, ETS transcription factor [Source:HGNC Symbol;Acc:HGNC:3325] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:7958835;12896968 Yes 1a1, Direct HQ evidence Sam Lambert Pratyush Das Yes $#ENSG00000111145#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:12788937$#ENSG00000111145#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:7851904 $#ENSP00000228741#ENSG00000111145#ENST00000228741#ETS#$#ENSP00000446806#ENSG00000111145#ENST00000547249#ETS#$#ENSP00000447857#ENSG00000111145#ENST00000547860#ETS#$#ENSP00000449430#ENSG00000111145#ENST00000552142#ETS# FALSE 1119 ENSG00000158711 ELK4 Ets Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000418; 2005 ELK4, ETS transcription factor [Source:HGNC Symbol;Acc:HGNC:3326] 1BC7 DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:8524663 Yes 1a1, Direct HQ evidence Sam Lambert Arttu Jolma Yes $#ENSG00000158711#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000158711#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:7851904 $#ENSP00000289703#ENSG00000158711#ENST00000289703#ETS#$#ENSP00000350681#ENSG00000158711#ENST00000357992#ETS#$#ENSP00000484946#ENSG00000158711#ENST00000468523#ETS# FALSE 1120 ENSG00000105722 ERF Ets Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000418; 2077 ETS2 repressor factor [Source:HGNC Symbol;Acc:HGNC:3444] None DBD and Full not tested None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:12533699 Yes 1a1, Direct HQ evidence Matt Weirauch Arttu Jolma Yes $#ENSG00000105722#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000222329#ENSG00000105722#ENST00000222329#ETS#$#ENSP00000388173#ENSG00000105722#ENST00000440177#ETS#$#ENSP00000468962#ENSG00000105722#ENST00000598965#ETS#$#ENSP00000469274#ENSG00000105722#ENST00000593944#ETS# FALSE 1121 ENSG00000157554 ERG Ets Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000418;IPR003118;IPR013761; 2078 ERG, ETS transcription factor [Source:HGNC Symbol;Acc:HGNC:3446] 4IRI DBD and Full Yes None None a Yes No Yes 1a1, Direct HQ evidence Laura Campitelli Yimeng Yin Yes $#ENSG00000157554#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000288319#ENSG00000157554#ENST00000288319#ETS#SAM_PNT$#ENSP00000381871#ENSG00000157554#ENST00000398897#ETS#SAM_PNT$#ENSP00000381877#ENSG00000157554#ENST00000398905#ETS#SAM_PNT$#ENSP00000381891#ENSG00000157554#ENST00000398919#ETS#SAM_PNT$#ENSP00000414150#ENSG00000157554#ENST00000417133#ETS#SAM_PNT$#ENSP00000396268#ENSG00000157554#ENST00000453032#ETS#SAM_PNT FALSE 1122 ENSG00000134954 ETS1 Ets Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000418;IPR003118;IPR013761;IPR016311 2113 ETS proto-oncogene 1, transcription factor [Source:HGNC Symbol;Acc:HGNC:3488] 1K78 DBD and Full Yes None None a Yes TF Gene_DNA-Binding: non-sequence-specific_DNA Binding; Transactivation_PMIDS:12119294 Yes 1a1, Direct HQ evidence Arttu Jolma Matt Weirauch Yes $#ENSG00000134954#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000134954#GO:0000982#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:21711453$#ENSG00000134954#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:11909962, PMID:15247905 $#ENSP00000324578#ENSG00000134954#ENST00000319397#ETS#SAM_PNT$#ENSP00000376436#ENSG00000134954#ENST00000392668#ETS#SAM_PNT$#ENSP00000435666#ENSG00000134954#ENST00000531611#ETS#SAM_PNT$#ENSP00000441430#ENSG00000134954#ENST00000535549#ETS# FALSE 1123 ENSG00000157557 ETS2 Ets Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000418;IPR003118;IPR013761;IPR016311;IPR027276; 2114 ETS proto-oncogene 2, transcription factor [Source:HGNC Symbol;Acc:HGNC:3489] 4BQA DBD and Full not tested None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:12637547;12928043 Yes 1a1, Direct HQ evidence Sam Lambert Arttu Jolma Yes $#ENSG00000157557#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:12637547$#ENSG00000157557#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:11909962 $#ENSP00000354194#ENSG00000157557#ENST00000360938#ETS#SAM_PNT$#ENSP00000353344#ENSG00000157557#ENST00000360214#ETS#SAM_PNT$#ENSP00000411086#ENSG00000157557#ENST00000456966#ETS#SAM_PNT$#ENSP00000401273#ENSG00000157557#ENST00000432278#ETS#SAM_PNT FALSE 1124 ENSG00000006468 ETV1 Ets Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000418;IPR006715 2115 ETS variant 1 [Source:HGNC Symbol;Acc:HGNC:3490] 4BNC DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:12750007 Yes 1a1, Direct HQ evidence Arttu Jolma Sam Lambert Yes $#ENSG00000006468#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:12750007$#ENSG00000006468#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:7700648 $#ENSP00000384138#ENSG00000006468#ENST00000403527#ETS#ETS_PEA3_N$#ENSP00000385686#ENSG00000006468#ENST00000403685#ETS#ETS_PEA3_N$#ENSP00000385381#ENSG00000006468#ENST00000405192#ETS#ETS_PEA3_N$#ENSP00000405327#ENSG00000006468#ENST00000430479#ETS#ETS_PEA3_N$#ENSP00000393078#ENSG00000006468#ENST00000438956#ETS#ETS_PEA3_N$#ENSP00000382293#ENSG00000006468#ENST00000399357#ETS#ETS_PEA3_N$#ENSP00000411626#ENSG00000006468#ENST00000420159#ETS#ETS_PEA3_N FALSE 1125 ENSG00000105672 ETV2 Ets Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000418; 2116 ETS variant 2 [Source:HGNC Symbol;Acc:HGNC:3491] None DBD Yes None None a Yes No Yes 1a1, Direct HQ evidence Arttu Jolma Laura Campitelli Yes $#ENSG00000105672#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000105672#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019 $#ENSP00000368309#ENSG00000105672#ENST00000379023#ETS#$#ENSP00000384524#ENSG00000105672#ENST00000402764#ETS#$#ENSP00000468453#ENSG00000105672#ENST00000479824#ETS#$#ENSP00000368312#ENSG00000105672#ENST00000379026#ETS#$#ENSP00000385369#ENSG00000105672#ENST00000403402#ETS#$#ENSP00000475089#ENSG00000105672#ENST00000591135#ETS# FALSE 1126 ENSG00000117036 ETV3 Ets Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000418; 2117 ETS variant 3 [Source:HGNC Symbol;Acc:HGNC:3492] None DBD Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:12007404 Yes 1a1, Direct HQ evidence Sam Lambert Pratyush Das Yes $#ENSG00000117036#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000117036#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IEA - GO_REF:0000019 $#ENSP00000327316#ENSG00000117036#ENST00000326786#ETS#$#ENSP00000357175#ENSG00000117036#ENST00000368192#ETS# FALSE 1127 ENSG00000253831 ETV3L Ets Yes Known motif Monomer or homomultimer 100 perc ID - in vitro None None IPR000418 440695 ETS variant 3 like [Source:HGNC Symbol;Acc:HGNC:33834] None not tested not tested None None b Yes No Yes 1a2, Orthologous HQ evidence Yimeng Yin Sam Lambert Yes $#ENSG00000253831#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000253831#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IEA - GO_REF:0000002 $#ENSP00000430271#ENSG00000253831#ENST00000454449#ETS# FALSE 1128 ENSG00000175832 ETV4 Ets Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000418;IPR006715 2118 ETS variant 4 [Source:HGNC Symbol;Acc:HGNC:3493] 4UUV DBD Yes None None a Yes TF Gene_DNA-Binding: sequence-specific; Transcription Factor Binding: tf co-factor binding_DNA Binding_PMIDS:15138262;15466854 Yes 1a1, Direct HQ evidence Pratyush Das Jussi Taipale Yes $#ENSG00000175832#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000175832#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IC - GO_REF:0000036 $#ENSP00000321835#ENSG00000175832#ENST00000319349#ETS#ETS_PEA3_N$#ENSP00000377273#ENSG00000175832#ENST00000393664#ETS#ETS_PEA3_N$#ENSP00000468636#ENSG00000175832#ENST00000586826#ETS#ETS_PEA3_N$#ENSP00000465718#ENSG00000175832#ENST00000591713#ETS#ETS_PEA3_N$#ENSP00000443846#ENSG00000175832#ENST00000538265#ETS#ETS_PEA3_N$#ENSP00000441749#ENSG00000175832#ENST00000545089#ETS#ETS_PEA3_N$#ENSP00000440023#ENSG00000175832#ENST00000545954#ETS#ETS_PEA3_N$#ENSP00000466673#ENSG00000175832#ENST00000586764#ETS#ETS_PEA3_N FALSE 1129 ENSG00000244405 ETV5 Ets Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000418;IPR006715 2119 ETS variant 5 [Source:HGNC Symbol;Acc:HGNC:3494] 4UNO DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:15138262;15466854;15857832 Yes 1a1, Direct HQ evidence Pratyush Das Sam Lambert Yes $#ENSG00000244405#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IMP - PMID:15857832$#ENSG00000244405#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:19443906 $#ENSP00000306894#ENSG00000244405#ENST00000306376#ETS#ETS_PEA3_N$#ENSP00000413755#ENSG00000244405#ENST00000434744#ETS#ETS_PEA3_N$#ENSP00000412171#ENSG00000244405#ENST00000421809#ETS#ETS_PEA3_N FALSE 1130 ENSG00000139083 ETV6 Ets Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000418;IPR003118;IPR013761; 2120 ETS variant 6 [Source:HGNC Symbol;Acc:HGNC:3495] 4MHG DBD and Full Yes None None a Yes No Yes 1a1, Direct HQ evidence Matt Weirauch Arttu Jolma Yes $#ENSG00000139083#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000139083#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000139083#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IC - GO_REF:0000036$#ENSG00000139083#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:7761424 $#ENSP00000379658#ENSG00000139083#ENST00000396373#ETS#SAM_PNT$#ENSP00000266427#ENSG00000139083#ENST00000266427#ETS#$#ENSP00000441463#ENSG00000139083#ENST00000545027#ETS#SAM_PNT FALSE 1131 ENSG00000010030 ETV7 Ets Yes Known motif Monomer or homomultimer High-throughput in vitro None Experimental low-throughput evidence of DNA-binding and changes in reporter expression (PMID: 11108721) IPR000418;IPR003118;IPR013761; 51513 ETS variant 7 [Source:HGNC Symbol;Acc:HGNC:18160] None DBD and Full not tested None None a Yes No Yes 1a1, Direct HQ evidence Sam Lambert Arttu Jolma Yes $#ENSG00000010030#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IDA - PMID:11108721 $#ENSP00000342260#ENSG00000010030#ENST00000339796#ETS#SAM_PNT$#ENSP00000341843#ENSG00000010030#ENST00000340181#ETS#SAM_PNT$#ENSP00000362842#ENSG00000010030#ENST00000373737#ETS#SAM_PNT$#ENSP00000362843#ENSG00000010030#ENST00000373738#ETS#$#ENSP00000481885#ENSG00000010030#ENST00000615781#ETS#$#ENSP00000484485#ENSG00000010030#ENST00000620358#ETS#SAM_PNT$#ENSP00000486712#ENSG00000010030#ENST00000627426#ETS#$#ENSP00000440592#ENSG00000010030#ENST00000538992#ETS# FALSE 1132 ENSG00000163497 FEV Ets Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000418; 54738 FEV, ETS transcription factor [Source:HGNC Symbol;Acc:HGNC:18562] 3ZP5 DBD not tested None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:9468386 Yes 1a1, Direct HQ evidence Yimeng Yin Jussi Taipale Yes $#ENSG00000163497#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000163497#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:9121764 $#ENSP00000295727#ENSG00000163497#ENST00000295727#ETS# FALSE 1133 ENSG00000151702 FLI1 Ets Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000418;IPR003118;IPR013761; 2313 Fli-1 proto-oncogene, ETS transcription factor [Source:HGNC Symbol;Acc:HGNC:3749] 5E8I DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_Transactivation_PMIDS:1445800;1522903;8449942;8502483;12065417;14570912 Yes 1a1, Direct HQ evidence Pratyush Das Arttu Jolma Yes $#ENSG00000151702#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000151702#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000151702#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:10891501 $#ENSP00000281428#ENSG00000151702#ENST00000281428#ETS#SAM_PNT$#ENSP00000433488#ENSG00000151702#ENST00000527786#ETS#SAM_PNT$#ENSP00000339627#ENSG00000151702#ENST00000344954#ETS#$#ENSP00000432950#ENSG00000151702#ENST00000534087#ETS#SAM_PNT FALSE 1134 ENSG00000154727 GABPA Ets Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000418;IPR003118;IPR013761;IPR016312;IPR024668;IPR029071 2551 GA binding protein transcription factor alpha subunit [Source:HGNC Symbol;Acc:HGNC:4071] 1AWC DBD Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:10773883;15361867 Yes 1a1, Direct HQ evidence Arttu Jolma Yimeng Yin Yes $#ENSG00000154727#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:12750007$#ENSG00000154727#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IDA - PMID:22306510$#ENSG00000154727#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:7590737, PMID:8441384 $#ENSP00000346886#ENSG00000154727#ENST00000354828#ETS#GABP-alpha, SAM_PNT$#ENSP00000382948#ENSG00000154727#ENST00000400075#ETS#GABP-alpha, SAM_PNT FALSE 1135 ENSG00000124664 SPDEF Ets Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000418;IPR003118;IPR013761; 25803 SAM pointed domain containing ETS transcription factor [Source:HGNC Symbol;Acc:HGNC:17257] 1YO5 DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific; Transcription Factor Binding: tf co-factor binding_DNA Binding; Transactivation_PMIDS:10625666 Yes 1a1, Direct HQ evidence Laura Campitelli Pratyush Das Yes $#ENSG00000124664#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000363149#ENSG00000124664#ENST00000374037#ETS#SAM_PNT$#ENSP00000442715#ENSG00000124664#ENST00000544425#ETS#SAM_PNT FALSE 1136 ENSG00000066336 SPI1 Ets Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000418; 6688 Spi-1 proto-oncogene [Source:HGNC Symbol;Acc:HGNC:11241] 1PUE DBD and Full not tested None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:9211934;10523830;7624145 Yes 1a1, Direct HQ evidence Matt Weirauch Pratyush Das Yes $#ENSG00000066336#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000066336#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000066336#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000066336#GO:0001205#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involv#IEA - GO_REF:0000019$#ENSG00000066336#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:12833137$#ENSG00000066336#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024 $#ENSP00000367799#ENSG00000066336#ENST00000378538#ETS#$#ENSP00000438846#ENSG00000066336#ENST00000533968#ETS#$#ENSP00000227163#ENSG00000066336#ENST00000227163#ETS#p47_phox_C$#ENSP00000443865#ENSG00000066336#ENST00000533030#ETS# FALSE 1137 ENSG00000269404 SPIB Ets Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000418;IPR006134;IPR025687; 6689 Spi-B transcription factor [Source:HGNC Symbol;Acc:HGNC:11242] None DBD and Full not tested None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:1406622 Yes 1a1, Direct HQ evidence Laura Campitelli Jussi Taipale Yes $#ENSG00000269404#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000270632#ENSG00000269404#ENST00000270632#ETS#$#ENSP00000471921#ENSG00000269404#ENST00000595883#ETS#$#ENSP00000391877#ENSG00000269404#ENST00000439922#ETS#$#ENSP00000470970#ENSG00000269404#ENST00000596074#ETS#$#ENSP00000472626#ENSG00000269404#ENST00000594685#ETS# FALSE 1138 ENSG00000166211 SPIC Ets Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000418; 121599 Spi-C transcription factor [Source:HGNC Symbol;Acc:HGNC:29549] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:12749910 Yes 1a1, Direct HQ evidence Sam Lambert Arttu Jolma Yes $#ENSG00000166211#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000448580#ENSG00000166211#ENST00000551346#ETS# FALSE 1139 ENSG00000163435 ELF3 Ets; AT hook Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000418;IPR003118;IPR013761; 1999 E74 like ETS transcription factor 3 [Source:HGNC Symbol;Acc:HGNC:3318] 3JTG DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:11893733 Yes 1a1, Direct HQ evidence Sam Lambert Pratyush Das Yes $#ENSG00000163435#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000163435#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000163435#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:9234700 $#ENSP00000352673#ENSG00000163435#ENST00000359651#ETS#SAM_PNT$#ENSP00000356252#ENSG00000163435#ENST00000367283#ETS#SAM_PNT$#ENSP00000356253#ENSG00000163435#ENST00000367284#ETS#SAM_PNT$#ENSP00000405162#ENSG00000163435#ENST00000446188#ETS#SAM_PNT FALSE 1140 ENSG00000059122 FLYWCH1 FLYWCH Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Several C. elegans FLYWCH domain proteins bind specific DNA sequences in Y1H and EMSA (PMID: 18794349 and PMID: 15165844). IPR007588;IPR029279 84256 FLYWCH-type zinc finger 1 [Source:HGNC Symbol;Acc:HGNC:25404] None not tested not tested None None No Yes No No 5a, one of the source datasets predicts is as a TF Tim Hughes Matt Weirauch No None $#ENSP00000253928#ENSG00000059122#ENST00000253928#FLYWCH#FLYWCH_N, FLYWCH_u$#ENSP00000344122#ENSG00000059122#ENST00000344592#FLYWCH#FLYWCH_u$#ENSP00000399938#ENSG00000059122#ENST00000416288#FLYWCH#FLYWCH_N, FLYWCH_u$#ENSP00000458661#ENSG00000059122#ENST00000573564#FLYWCH#FLYWCH_u$#ENSP00000458282#ENSG00000059122#ENST00000570425#FLYWCH#FLYWCH_N$#ENSP00000461566#ENSG00000059122#ENST00000571580#FLYWCH#$#ENSP00000458689#ENSG00000059122#ENST00000571983#FLYWCH#$#ENSP00000459326#ENSG00000059122#ENST00000573525#FLYWCH#FLYWCH_N$#ENSP00000459480#ENSG00000059122#ENST00000575679#FLYWCH# FALSE 1141 ENSG00000129514 FOXA1 Forkhead Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001766;IPR013638;IPR018122;IPR018533 3169 forkhead box A1 [Source:HGNC Symbol;Acc:HGNC:5021] None DBD and Full not tested None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:2227418;11864602;15485926;15539431 Yes 1a1, Direct HQ evidence Yimeng Yin Jussi Taipale Yes $#ENSG00000129514#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000129514#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#ISS - GO_REF:0000024$#ENSG00000129514#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:8652662$#ENSG00000129514#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IMP - PMID:16087863 $#ENSP00000250448#ENSG00000129514#ENST00000250448#Forkhead#Forkhead_N, HNF_C FALSE 1142 ENSG00000125798 FOXA2 Forkhead Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001766;IPR013638;IPR018122;IPR018533 3170 forkhead box A2 [Source:HGNC Symbol;Acc:HGNC:5022] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:16847327 Yes 1a1, Direct HQ evidence Matt Weirauch Jussi Taipale Yes $#ENSG00000125798#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000125798#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:12124776, PMID:12911579, PMID:9931457$#ENSG00000125798#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#IMP - PMID:12642491 $#ENSP00000366319#ENSG00000125798#ENST00000377115#Forkhead#Forkhead_N, HNF_C$#ENSP00000400341#ENSG00000125798#ENST00000419308#Forkhead#Forkhead_N, HNF_C FALSE 1143 ENSG00000170608 FOXA3 Forkhead Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001766;IPR013638;IPR018122;IPR018533 3171 forkhead box A3 [Source:HGNC Symbol;Acc:HGNC:5023] 1VTN DBD and Full Yes None None a Yes No Yes 1a1, Direct HQ evidence Sam Lambert Yimeng Yin Yes $#ENSG00000170608#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000170608#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:12695546 | TAS - PMID:9369482 $#ENSP00000304004#ENSG00000170608#ENST00000302177#Forkhead#Forkhead_N, HNF_C$#ENSP00000470816#ENSG00000170608#ENST00000594297#Forkhead#Forkhead_N FALSE 1144 ENSG00000171956 FOXB1 Forkhead Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001766;IPR018122 27023 forkhead box B1 [Source:HGNC Symbol;Acc:HGNC:3799] None DBD and Full Yes None None a Yes Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0 Yes 1a1, Direct HQ evidence Matt Weirauch Pratyush Das Yes $#ENSG00000171956#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000379369#ENSG00000171956#ENST00000396057#Forkhead# FALSE 1145 ENSG00000204612 FOXB2 Forkhead Yes Inferred motif Monomer or homomultimer High-throughput in vitro None None IPR001766;IPR018122 442425 forkhead box B2 [Source:HGNC Symbol;Acc:HGNC:23315] None not tested not tested None None x Yes No Yes 1a2, Orthologous HQ evidence Arttu Jolma Pratyush Das Yes $#ENSG00000204612#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000365898#ENSG00000204612#ENST00000376708#Forkhead# FALSE 1146 ENSG00000054598 FOXC1 Forkhead Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001766;IPR018122 2296 forkhead box C1 [Source:HGNC Symbol;Acc:HGNC:3800] None DBD Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:11179011;17000708;12533514;15684392 Yes 1a1, Direct HQ evidence Jussi Taipale Matt Weirauch Yes $#ENSG00000054598#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000054598#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IC - GO_REF:0000036$#ENSG00000054598#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:11179011, PMID:11782474, PMID:14506133,$#ENSG00000054598#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019 $#ENSP00000370256#ENSG00000054598#ENST00000380874#Forkhead# FALSE 1147 ENSG00000176692 FOXC2 Forkhead Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001766;IPR018122 2303 forkhead box C2 [Source:HGNC Symbol;Acc:HGNC:3801] None DBD and Full Yes None None b Yes No Yes 1a1, Direct HQ evidence Sam Lambert Yimeng Yin Yes $#ENSG00000176692#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:20956529$#ENSG00000176692#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:9169153$#ENSG00000176692#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019 $#ENSP00000326371#ENSG00000176692#ENST00000320354#Forkhead# FALSE 1148 ENSG00000251493 FOXD1 Forkhead Yes Known motif Monomer or homomultimer 100 perc ID - in vitro None None IPR001766;IPR018122 2297 forkhead box D1 [Source:HGNC Symbol;Acc:HGNC:3802] None not tested not tested None PMID: 7957066, regular GTAAACA-consensus; TFs that are in CisBP but not in Vaquerizas set No Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:7957066;13678594 Yes 1a1, Direct HQ evidence Sam Lambert Pratyush Das Yes $#ENSG00000251493#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000251493#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000251493#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:8702877 $#ENSP00000481581#ENSG00000251493#ENST00000615637#Forkhead# FALSE 1149 ENSG00000186564 FOXD2 Forkhead Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001766;IPR018122 2306 forkhead box D2 [Source:HGNC Symbol;Acc:HGNC:3803] None DBD not tested None None b Yes TF Gene Candidate_DNA-Binding: sequence-specific_Transactivation_PMIDS:12621056 Yes 1a1, Direct HQ evidence Sam Lambert Jussi Taipale Yes $#ENSG00000186564#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000186564#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:9403061 $#ENSP00000335493#ENSG00000186564#ENST00000334793#Forkhead# FALSE 1150 ENSG00000187140 FOXD3 Forkhead Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001766;IPR018122 27022 forkhead box D3 [Source:HGNC Symbol;Acc:HGNC:3804] 2HDC DBD Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:8139574 Yes 1a1, Direct HQ evidence Pratyush Das Yimeng Yin Yes $#ENSG00000187140#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IDA - PMID:22306510$#ENSG00000187140#GO:0003700#sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024 $#ENSP00000360157#ENSG00000187140#ENST00000371116#Forkhead# FALSE 1151 ENSG00000170122 FOXD4 Forkhead Yes Inferred motif Monomer or homomultimer In vivo/Misc source None None IPR001766; 2298 forkhead box D4 [Source:HGNC Symbol;Acc:HGNC:3805] None Full Yes None None b Yes No Yes 1a2, Orthologous HQ evidence Sam Lambert Yimeng Yin Yes $#ENSG00000170122#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000170122#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:9325056 $#ENSP00000371940#ENSG00000170122#ENST00000382500#Forkhead# FALSE 1152 ENSG00000184492 FOXD4L1 Forkhead Yes Inferred motif Monomer or homomultimer In vivo/Misc source None None IPR001766;IPR018122 200350 forkhead box D4-like 1 [Source:HGNC Symbol;Acc:HGNC:18521] None DBD and Full not tested None None b Yes No Yes 1a2, Orthologous HQ evidence Sam Lambert Arttu Jolma Yes $#ENSG00000184492#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000302756#ENSG00000184492#ENST00000306507#Forkhead# FALSE 1153 ENSG00000204828 FOXD4L2 Forkhead No Unlikely to be sequence specific TF Not a DNA binding protein No motif Only known motifs are from Transfac or HocoMoco - origin is uncertain This ENSEMBL ID has been retired. None None forkhead box D4-like 2 None Full not tested None This ENSEMBL ID has been retired. No No No No Protein added after initial stage, no initial assesment Arttu Jolma Sam Lambert No None None FALSE 1154 ENSG00000187559 FOXD4L3 Forkhead Yes Inferred motif Monomer or homomultimer In vivo/Misc source None None IPR001766;IPR018122 286380 forkhead box D4-like 3 [Source:HGNC Symbol;Acc:HGNC:18523] None Full not tested None None b Yes No Yes 1a2, Orthologous HQ evidence Sam Lambert Jussi Taipale Yes $#ENSG00000187559#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000341961#ENSG00000187559#ENST00000342833#Forkhead# FALSE 1155 ENSG00000184659 FOXD4L4 Forkhead Yes Known motif Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain None IPR001766;IPR018122 349334 forkhead box D4-like 4 [Source:HGNC Symbol;Acc:HGNC:23762] None Full not tested None None b Yes No Yes 2a1, Lower confidence direct evidence Sam Lambert Pratyush Das Yes $#ENSG00000184659#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000366630#ENSG00000184659#ENST00000377413#Forkhead# FALSE 1156 ENSG00000204779 FOXD4L5 Forkhead Yes Inferred motif Monomer or homomultimer In vivo/Misc source None None IPR001766;IPR018122 653427 forkhead box D4-like 5 [Source:HGNC Symbol;Acc:HGNC:18522] None not tested not tested None None x Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:7957066;15302827 Yes 1a2, Orthologous HQ evidence Laura Campitelli Yimeng Yin Yes $#ENSG00000204779#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000366637#ENSG00000204779#ENST00000377420#Forkhead# FALSE 1157 ENSG00000273514 FOXD4L6 Forkhead Yes Inferred motif Monomer or homomultimer In vivo/Misc source None None IPR001766;IPR018122 653404 forkhead box D4-like 6 [Source:HGNC Symbol;Acc:HGNC:31986] None DBD and Full not tested None None b Yes No Yes 1a2, Orthologous HQ evidence Pratyush Das Arttu Jolma Yes $#ENSG00000273514#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000484875#ENSG00000273514#ENST00000622588#Forkhead# FALSE 1158 ENSG00000178919 FOXE1 Forkhead Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001766;IPR018122 2304 forkhead box E1 [Source:HGNC Symbol;Acc:HGNC:3806] None DBD not tested None None a Yes Indeterminate - There is no evidence for or against this genes role as a TF__TF PPI_PMIDS:15367491;15223130 Yes 1a1, Direct HQ evidence Sam Lambert Arttu Jolma Yes $#ENSG00000178919#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033 | IDA - PMID:24219130 | IMP -$#ENSG00000178919#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:9697705 $#ENSP00000364265#ENSG00000178919#ENST00000375123#Forkhead# FALSE 1159 ENSG00000186790 FOXE3 Forkhead Yes Inferred motif Monomer or homomultimer High-throughput in vitro None None IPR001766;IPR018122 2301 forkhead box E3 [Source:HGNC Symbol;Acc:HGNC:3808] None not tested not tested None None b Yes Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0 Yes 1a2, Orthologous HQ evidence Laura Campitelli Pratyush Das Yes $#ENSG00000186790#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000186790#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:10652278, PMID:25504734 | TAS - PMID:88 $#ENSP00000334472#ENSG00000186790#ENST00000335071#Forkhead# FALSE 1160 ENSG00000103241 FOXF1 Forkhead Yes Known motif Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain None IPR001766;IPR018122 2294 forkhead box F1 [Source:HGNC Symbol;Acc:HGNC:3809] None DBD and Full not tested None None b Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:8626802 Yes 2a1, Lower confidence direct evidence Sam Lambert Arttu Jolma Yes $#ENSG00000103241#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IMP - PMID:8626802$#ENSG00000103241#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000262426#ENSG00000103241#ENST00000262426#Forkhead# FALSE 1161 ENSG00000137273 FOXF2 Forkhead Yes Known motif Monomer or homomultimer In vivo/Misc source None None IPR001766;IPR018122 2295 forkhead box F2 [Source:HGNC Symbol;Acc:HGNC:3810] None DBD Yes None None b Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:8626802 Yes 1a1, Direct HQ evidence Sam Lambert Arttu Jolma Yes $#ENSG00000137273#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IDA - PMID:8626802 | IMP - PMID:8626802$#ENSG00000137273#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:9722567$#ENSG00000137273#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000259806#ENSG00000137273#ENST00000259806#Forkhead# FALSE 1162 ENSG00000176165 FOXG1 Forkhead Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001766;IPR018122 2290 forkhead box G1 [Source:HGNC Symbol;Acc:HGNC:3811] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:7585630;16314515;17482455 Yes 1a1, Direct HQ evidence Pratyush Das Yimeng Yin Yes $#ENSG00000176165#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000339004#ENSG00000176165#ENST00000313071#Forkhead# FALSE 1163 ENSG00000160973 FOXH1 Forkhead Yes Known motif Monomer or homomultimer In vivo/Misc source None Full length protein did not yield an HT-SELEX motif IPR001766; 8928 forkhead box H1 [Source:HGNC Symbol;Acc:HGNC:3814] None DBD not tested None PMID:25359723 ChIP-seq, PWM is not a canonical FOX-site but has AATCCACA consensus also in Jaspar ChIP-seq_JASPAR_Mathelier_2014_Direct a Yes TF Gene_Transcription Factor Binding: tf co-factor binding; DNA-Binding: sequence-specific_Co-activation; DNA Binding; TF PPI_PMIDS:9702197;9858566 Yes 2a1, Lower confidence direct evidence Jussi Taipale Pratyush Das Yes $#ENSG00000160973#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000160973#GO:0001205#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involv#IEA - GO_REF:0000019$#ENSG00000160973#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:17438144 | NAS - PMID:17507406$#ENSG00000160973#GO:2000824#negative regulation of androgen receptor activity#IDA - PMID:16120611 $#ENSP00000366534#ENSG00000160973#ENST00000377317#Forkhead# FALSE 1164 ENSG00000168269 FOXI1 Forkhead Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001766;IPR018122 2299 forkhead box I1 [Source:HGNC Symbol;Acc:HGNC:3815] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:9153225 Yes 1a1, Direct HQ evidence Laura Campitelli Jussi Taipale Yes $#ENSG00000168269#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:19214237$#ENSG00000168269#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:19214237 $#ENSP00000304286#ENSG00000168269#ENST00000306268#Forkhead#$#ENSP00000415483#ENSG00000168269#ENST00000449804#Forkhead# FALSE 1165 ENSG00000186766 FOXI2 Forkhead Yes Inferred motif Monomer or homomultimer High-throughput in vitro None None IPR001766;IPR018122 399823 forkhead box I2 [Source:HGNC Symbol;Acc:HGNC:32448] None DBD Yes None None c Yes No Yes 1a2, Orthologous HQ evidence Arttu Jolma Jussi Taipale Yes $#ENSG00000186766#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000373572#ENSG00000186766#ENST00000388920#Forkhead# FALSE 1166 ENSG00000214336 FOXI3 Forkhead Yes Inferred motif Monomer or homomultimer High-throughput in vitro None None IPR001766;IPR018122 344167 forkhead box I3 [Source:HGNC Symbol;Acc:HGNC:35123] None not tested not tested None PMID: 26450968 Our results suggest that Foxi3 maintains dental epithelial cells in an undifferentiated state and thereby regulates multiple stages of tooth morphogenesis No Yes No Yes 3a, decent circumstantial evidence for its role as Sam Lambert Yimeng Yin Yes $#ENSG00000214336#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000478384#ENSG00000214336#ENST00000428390#Forkhead# FALSE 1167 ENSG00000129654 FOXJ1 Forkhead Yes Known motif Monomer or homomultimer 100 perc ID - in vitro None None IPR001766;IPR018122 2302 forkhead box J1 [Source:HGNC Symbol;Acc:HGNC:3816] None DBD and Full Yes None None b Yes No Yes 1a1, Direct HQ evidence Sam Lambert Jussi Taipale Yes $#ENSG00000129654#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000129654#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000129654#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:9073514$#ENSG00000129654#GO:0032088#negative regulation of NF-kappaB transcription factor activity#ISS - GO_REF:0000024 $#ENSP00000323880#ENSG00000129654#ENST00000322957#Forkhead# FALSE 1168 ENSG00000065970 FOXJ2 Forkhead Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001766; 55810 forkhead box J2 [Source:HGNC Symbol;Acc:HGNC:24818] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:10777590 Yes 1a1, Direct HQ evidence Matt Weirauch Tim Hughes Yes $#ENSG00000065970#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:10777590 $#ENSP00000162391#ENSG00000065970#ENST00000162391#Forkhead#$#ENSP00000403411#ENSG00000065970#ENST00000428177#Forkhead# FALSE 1169 ENSG00000198815 FOXJ3 Forkhead Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001766;IPR018122 22887 forkhead box J3 [Source:HGNC Symbol;Acc:HGNC:29178] None DBD and Full Yes None None b Yes No Yes 1a1, Direct HQ evidence Jussi Taipale Laura Campitelli Yes $#ENSG00000198815#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000354620#ENSG00000198815#ENST00000361346#Forkhead#$#ENSP00000361653#ENSG00000198815#ENST00000372572#Forkhead#$#ENSP00000393408#ENSG00000198815#ENST00000445886#Forkhead#$#ENSP00000439044#ENSG00000198815#ENST00000545068#Forkhead#$#ENSP00000361652#ENSG00000198815#ENST00000372571#Forkhead#$#ENSP00000361654#ENSG00000198815#ENST00000372573#Forkhead#$#ENSP00000388099#ENSG00000198815#ENST00000422278#Forkhead#$#ENSP00000403060#ENSG00000198815#ENST00000454417#Forkhead# FALSE 1170 ENSG00000164916 FOXK1 Forkhead Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000253;IPR001766;IPR008984;IPR018122 221937 forkhead box K1 [Source:HGNC Symbol;Acc:HGNC:23480] None DBD Yes None None c Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:8007964;9271401 Yes 1a1, Direct HQ evidence Matt Weirauch Sam Lambert Yes $#ENSG00000164916#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000328720#ENSG00000164916#ENST00000328914#Forkhead#FHA$#ENSP00000475486#ENSG00000164916#ENST00000460979#Forkhead# FALSE 1171 ENSG00000141568 FOXK2 Forkhead Yes Inferred motif Monomer or homomultimer High-throughput in vitro None None IPR000253;IPR001766;IPR008984;IPR018122 3607 forkhead box K2 [Source:HGNC Symbol;Acc:HGNC:6036] 2C6Y DBD not tested None The crystal is an interesting through-DNA homodimer a Yes No Yes 1a1, Direct HQ evidence Arttu Jolma Laura Campitelli Yes $#ENSG00000141568#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:9065434$#ENSG00000141568#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:12402362 $#ENSP00000335677#ENSG00000141568#ENST00000335255#Forkhead#FHA$#ENSP00000461540#ENSG00000141568#ENST00000575578#Forkhead#$#ENSP00000433167#ENSG00000141568#ENST00000531030#Forkhead#$#ENSP00000432663#ENSG00000141568#ENST00000526383#Forkhead# FALSE 1172 ENSG00000176678 FOXL1 Forkhead Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001766;IPR018122 2300 forkhead box L1 [Source:HGNC Symbol;Acc:HGNC:3817] None DBD and Full Yes None None b Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:7957066 Yes 1a1, Direct HQ evidence Jussi Taipale Arttu Jolma Yes $#ENSG00000176678#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000176678#GO:0003700#sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024 $#ENSP00000472376#ENSG00000176678#ENST00000593625#Forkhead#$#ENSP00000326272#ENSG00000176678#ENST00000320241#Forkhead# FALSE 1173 ENSG00000183770 FOXL2 Forkhead Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001766;IPR018122 668 forkhead box L2 [Source:HGNC Symbol;Acc:HGNC:1092] None DBD and Full not tested None None b Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:15059956 Yes 1a1, Direct HQ evidence Pratyush Das Sam Lambert Yes $#ENSG00000183770#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000183770#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000183770#GO:0003700#sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024 | NAS - PMID:11175783, PMID:1 $#ENSP00000333188#ENSG00000183770#ENST00000330315#Forkhead# FALSE 1174 ENSG00000111206 FOXM1 Forkhead Yes Known motif Monomer or homomultimer 100 perc ID - in vitro None None IPR001766;IPR018122 2305 forkhead box M1 [Source:HGNC Symbol;Acc:HGNC:3818] 3G73 DBD and Full Yes None None a Yes TF Gene_Transcription Regulatory Activity: heterochromatin interaction/binding; DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:9108152;9242644 Yes 1a1, Direct HQ evidence Sam Lambert Yimeng Yin Yes $#ENSG00000111206#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000342307#ENSG00000111206#ENST00000342628#Forkhead#$#ENSP00000352901#ENSG00000111206#ENST00000359843#Forkhead#$#ENSP00000354492#ENSG00000111206#ENST00000361953#Forkhead#$#ENSP00000486536#ENSG00000111206#ENST00000627656#Forkhead#$#ENSP00000442309#ENSG00000111206#ENST00000535350#Forkhead# FALSE 1175 ENSG00000109101 FOXN1 Forkhead Yes Known motif Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain None IPR001766; 8456 forkhead box N1 [Source:HGNC Symbol;Acc:HGNC:12765] None DBD Yes None None a Yes Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0 Yes 1a1, Direct HQ evidence Jussi Taipale Yimeng Yin Yes $#ENSG00000109101#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000226247#ENSG00000109101#ENST00000226247#Forkhead#$#ENSP00000464645#ENSG00000109101#ENST00000579795#Forkhead#$#ENSP00000462159#ENSG00000109101#ENST00000577936#Forkhead# FALSE 1176 ENSG00000170802 FOXN2 Forkhead Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001766;IPR018122 3344 forkhead box N2 [Source:HGNC Symbol;Acc:HGNC:5281] None DBD and Full Yes None None a Yes No Yes 1a1, Direct HQ evidence Arttu Jolma Pratyush Das Yes $#ENSG00000170802#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002 $#ENSP00000343633#ENSG00000170802#ENST00000340553#Forkhead#$#ENSP00000388486#ENSG00000170802#ENST00000413569#Forkhead#$#ENSP00000484534#ENSG00000170802#ENST00000616844#Forkhead# FALSE 1177 ENSG00000053254 FOXN3 Forkhead Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001766;IPR018122 1112 forkhead box N3 [Source:HGNC Symbol;Acc:HGNC:1928] None DBD and Full Yes None None b Yes No Yes 1a1, Direct HQ evidence Yimeng Yin Matt Weirauch Yes $#ENSG00000053254#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000261302#ENSG00000053254#ENST00000261302#Forkhead#$#ENSP00000343288#ENSG00000053254#ENST00000345097#Forkhead#$#ENSP00000452227#ENSG00000053254#ENST00000555353#Forkhead#$#ENSP00000452005#ENSG00000053254#ENST00000557258#Forkhead#$#ENSP00000479114#ENSG00000053254#ENST00000615335#Forkhead#$#ENSP00000452444#ENSG00000053254#ENST00000553353#Forkhead#$#ENSP00000451902#ENSG00000053254#ENST00000553904#Forkhead#$#ENSP00000452290#ENSG00000053254#ENST00000555034#Forkhead#$#ENSP00000450684#ENSG00000053254#ENST00000556916#Forkhead#$#ENSP00000450783#ENSG00000053254#ENST00000557572#Forkhead# FALSE 1178 ENSG00000139445 FOXN4 Forkhead Yes Known motif Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain None IPR001766; 121643 forkhead box N4 [Source:HGNC Symbol;Acc:HGNC:21399] None DBD and Full Yes None None b Yes Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0 Yes 1a1, Direct HQ evidence Arttu Jolma Yimeng Yin Yes $#ENSG00000139445#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 | ISS - GO_REF:0000024 $#ENSP00000299162#ENSG00000139445#ENST00000299162#Forkhead#$#ENSP00000347354#ENSG00000139445#ENST00000355216#Forkhead#$#ENSP00000474754#ENSG00000139445#ENST00000468516#Forkhead# FALSE 1179 ENSG00000150907 FOXO1 Forkhead Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001766; 2308 forkhead box O1 [Source:HGNC Symbol;Acc:HGNC:3819] 3CO6 DBD and Full Yes None None b Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:10385407 Yes 1a1, Direct HQ evidence Sam Lambert Yimeng Yin Yes $#ENSG00000150907#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000150907#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019 $#ENSP00000368880#ENSG00000150907#ENST00000379561#Forkhead#FOXO-TAD, FOXO_KIX_bdg FALSE 1180 ENSG00000118689 FOXO3 Forkhead Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001766; 2309 forkhead box O3 [Source:HGNC Symbol;Acc:HGNC:3821] 2UZK DBD and Full Yes None None b Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:10102273 Yes 1a1, Direct HQ evidence Pratyush Das Tim Hughes Yes $#ENSG00000118689#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IDA - PMID:20371612$#ENSG00000118689#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IEA - GO_REF:0000019$#ENSG00000118689#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:14734530 $#ENSP00000339527#ENSG00000118689#ENST00000343882#Forkhead#FOXO-TAD, FOXO_KIX_bdg$#ENSP00000385824#ENSG00000118689#ENST00000406360#Forkhead#FOXO-TAD, FOXO_KIX_bdg$#ENSP00000446316#ENSG00000118689#ENST00000540898#Forkhead#FOXO-TAD, FOXO_KIX_bdg FALSE 1181 ENSG00000184481 FOXO4 Forkhead Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001766; 4303 forkhead box O4 [Source:HGNC Symbol;Acc:HGNC:7139] 3L2C DBD and Full Yes None None a Yes TF Gene Candidate_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:11777915 Yes 1a1, Direct HQ evidence Laura Campitelli Arttu Jolma Yes $#ENSG00000184481#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000184481#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:10783894 $#ENSP00000363377#ENSG00000184481#ENST00000374259#Forkhead#FOXO-TAD, FOXO_KIX_bdg$#ENSP00000342209#ENSG00000184481#ENST00000341558#Forkhead#FOXO-TAD, FOXO_KIX_bdg FALSE 1182 ENSG00000204060 FOXO6 Forkhead Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001766; 100132074 forkhead box O6 [Source:HGNC Symbol;Acc:HGNC:24814] None DBD Yes None None x Yes TF Gene_DNA-Binding: sequence-specific_Transactivation_PMIDS:12857750;15987244 Yes 1a1, Direct HQ evidence Arttu Jolma Jussi Taipale Yes $#ENSG00000204060#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033 | ISS - GO_REF:0000024 $#ENSP00000361672#ENSG00000204060#ENST00000372591#Forkhead# FALSE 1183 ENSG00000114861 FOXP1 Forkhead Yes Known motif Monomer or homomultimer High-throughput in vitro Has a putative AT-hook None IPR001766; 27086 forkhead box P1 [Source:HGNC Symbol;Acc:HGNC:3823] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:8265594;16819554 Yes 1a1, Direct HQ evidence Laura Campitelli Pratyush Das Yes $#ENSG00000114861#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000318721#ENSG00000114861#ENST00000318779#Forkhead#$#ENSP00000318902#ENSG00000114861#ENST00000318789#Forkhead#FOXP-CC$#ENSP00000419393#ENSG00000114861#ENST00000475937#Forkhead#FOXP-CC$#ENSP00000418225#ENSG00000114861#ENST00000497355#Forkhead#FOXP-CC$#ENSP00000417857#ENSG00000114861#ENST00000484350#Forkhead#FOXP-CC$#ENSP00000420736#ENSG00000114861#ENST00000491238#Forkhead#FOXP-CC$#ENSP00000418524#ENSG00000114861#ENST00000493089#Forkhead#FOXP-CC$#ENSP00000418102#ENSG00000114861#ENST00000498215#Forkhead#FOXP-CC$#ENSP00000482847#ENSG00000114861#ENST00000614176#Forkhead#FOXP-CC$#ENSP00000484963#ENSG00000114861#ENST00000472382#Forkhead#$#ENSP00000417941#ENSG00000114861#ENST00000485326#Forkhead#FOXP-CC$#ENSP00000477918#ENSG00000114861#ENST00000622151#Forkhead# FALSE 1184 ENSG00000128573 FOXP2 Forkhead Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001766; 93986 forkhead box P2 [Source:HGNC Symbol;Acc:HGNC:13875] 2A07 DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_Transactivation_PMIDS:11358962;14701752;11358962;14701752 Yes 1a1, Direct HQ evidence Jussi Taipale Matt Weirauch Yes $#ENSG00000128573#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000128573#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000128573#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:18987363 $#ENSP00000265436#ENSG00000128573#ENST00000350908#Forkhead#FOXP-CC$#ENSP00000353367#ENSG00000128573#ENST00000360232#Forkhead#FOXP-CC$#ENSP00000367482#ENSG00000128573#ENST00000378237#Forkhead#CDC45, FOXP-CC$#ENSP00000375084#ENSG00000128573#ENST00000390668#Forkhead#CDC45, FOXP-CC$#ENSP00000377129#ENSG00000128573#ENST00000393489#Forkhead#CDC45, FOXP-CC$#ENSP00000386200#ENSG00000128573#ENST00000408937#Forkhead#CDC45, FOXP-CC$#ENSP00000418100#ENSG00000128573#ENST00000462331#Forkhead#$#ENSP00000385069#ENSG00000128573#ENST00000403559#Forkhead#CDC45, FOXP-CC FALSE 1185 ENSG00000049768 FOXP3 Forkhead Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001766;IPR007087 50943 forkhead box P3 [Source:HGNC Symbol;Acc:HGNC:6106] 3QRF DBD and Full not tested None None b Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:17028180 Yes 1a1, Direct HQ evidence Sam Lambert Pratyush Das Yes $#ENSG00000049768#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000049768#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:11483607 | NAS - PMID:11138001$#ENSG00000049768#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019$#ENSG00000049768#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IDA - PMID:16652169$#ENSG00000049768#GO:0032792#negative regulation of CREB transcription factor activity#IDA - PMID:16652169$#ENSG00000049768#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:16873067 $#ENSP00000365380#ENSG00000049768#ENST00000376207#Forkhead#FOXP-CC$#ENSP00000428952#ENSG00000049768#ENST00000518685#Forkhead#FOXP-CC$#ENSP00000365372#ENSG00000049768#ENST00000376199#Forkhead#FOXP-CC$#ENSP00000451208#ENSG00000049768#ENST00000557224#Forkhead#FOXP-CC FALSE 1186 ENSG00000137166 FOXP4 Forkhead Yes Inferred motif Monomer or homomultimer High-throughput in vitro None None IPR001766; 116113 forkhead box P4 [Source:HGNC Symbol;Acc:HGNC:20842] None DBD and Full not tested None None b Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:14701752 Yes 1a2, Orthologous HQ evidence Sam Lambert Jussi Taipale Yes $#ENSG00000137166#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000309823#ENSG00000137166#ENST00000307972#Forkhead#FOXP-CC$#ENSP00000362148#ENSG00000137166#ENST00000373057#Forkhead#FOXP-CC$#ENSP00000362154#ENSG00000137166#ENST00000373063#Forkhead#FOXP-CC$#ENSP00000393704#ENSG00000137166#ENST00000451305#Forkhead# FALSE 1187 ENSG00000164379 FOXQ1 Forkhead Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001766;IPR018122 94234 forkhead box Q1 [Source:HGNC Symbol;Acc:HGNC:20951] None DBD and Full not tested None None b Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:10896677 Yes 1a1, Direct HQ evidence Matt Weirauch Laura Campitelli Yes $#ENSG00000164379#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000296839#ENSG00000164379#ENST00000296839#Forkhead# FALSE 1188 ENSG00000176302 FOXR1 Forkhead Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001766; 283150 forkhead box R1 [Source:HGNC Symbol;Acc:HGNC:29980] None DBD and Full Yes None None b Yes No Yes 1a1, Direct HQ evidence Jussi Taipale Laura Campitelli Yes $#ENSG00000176302#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000314806#ENSG00000176302#ENST00000317011#Forkhead#$#ENSP00000432358#ENSG00000176302#ENST00000533282#Forkhead# FALSE 1189 ENSG00000189299 FOXR2 Forkhead Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001766; 139628 forkhead box R2 [Source:HGNC Symbol;Acc:HGNC:30469] None DBD and Full Yes None None b Yes No Yes 1a1, Direct HQ evidence Jussi Taipale Pratyush Das Yes $#ENSG00000189299#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000427329#ENSG00000189299#ENST00000339140#Forkhead# FALSE 1190 ENSG00000179772 FOXS1 Forkhead Yes Inferred motif Monomer or homomultimer High-throughput in vitro None None IPR001766;IPR018122 2307 forkhead box S1 [Source:HGNC Symbol;Acc:HGNC:3735] None DBD and Full not tested None None b Yes No Yes 1a2, Orthologous HQ evidence Arttu Jolma Laura Campitelli Yes $#ENSG00000179772#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000179772#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:9325056$#ENSG00000179772#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024 $#ENSP00000365145#ENSG00000179772#ENST00000375978#Forkhead# FALSE 1191 ENSG00000072121 ZFYVE26 FYVE-type ZF No Unlikely to be sequence specific TF Not a DNA binding protein No motif None FYVE zinc fingers are unlikely to bind DNA IPR000306;IPR011011;IPR017455; 23503 zinc finger FYVE-type containing 26 [Source:HGNC Symbol;Acc:HGNC:20761] None not tested not tested None None c No No No 5a, one of the source datasets predicts is as a TF Sam Lambert Matt Weirauch No None $#ENSP00000251119#ENSG00000072121#ENST00000347230#Other#FYVE, TPR_2$#ENSP00000450603#ENSG00000072121#ENST00000555452#Other#FYVE, TPR_14, TPR_2$#ENSP00000452142#ENSG00000072121#ENST00000557306#Other# FALSE 1192 ENSG00000102145 GATA1 GATA Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000679;IPR016374 2623 GATA binding protein 1 [Source:HGNC Symbol;Acc:HGNC:4170] 1GAT DBD and Full not tested None None a Yes TF Gene_DNA-Binding: sequence-specific_Transactivation_PMIDS:1650452;2725678 Yes 1a1, Direct HQ evidence Tim Hughes Yimeng Yin Yes $#ENSG00000102145#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000102145#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:15920471$#ENSG00000102145#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IBA - GO_REF:0000033$#ENSG00000102145#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:2467208 $#ENSP00000365858#ENSG00000102145#ENST00000376670#GATA#$#ENSP00000365853#ENSG00000102145#ENST00000376665#GATA# FALSE 1193 ENSG00000179348 GATA2 GATA Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000679;IPR016374 2624 GATA binding protein 2 [Source:HGNC Symbol;Acc:HGNC:4171] None DBD and Full not tested None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:9565596;14512418 Yes 1a1, Direct HQ evidence Laura Campitelli Pratyush Das Yes $#ENSG00000179348#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000179348#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IBA - GO_REF:0000033$#ENSG00000179348#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:15016828, PMID:20206639 $#ENSP00000345681#ENSG00000179348#ENST00000341105#GATA#$#ENSP00000400259#ENSG00000179348#ENST00000430265#GATA#$#ENSP00000417074#ENSG00000179348#ENST00000487848#GATA#$#ENSP00000419532#ENSG00000179348#ENST00000498200#GATA#$#ENSP00000418132#ENSG00000179348#ENST00000492608#GATA# FALSE 1194 ENSG00000107485 GATA3 GATA Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000679;IPR016374 2625 GATA binding protein 3 [Source:HGNC Symbol;Acc:HGNC:4172] 3DFV DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:8332492 Yes 1a1, Direct HQ evidence Sam Lambert Yimeng Yin Yes $#ENSG00000107485#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000107485#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IMP - PMID:19674970$#ENSG00000107485#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IBA - GO_REF:0000033$#ENSG00000107485#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:2050118, PMID:8088776 $#ENSP00000341619#ENSG00000107485#ENST00000346208#GATA#$#ENSP00000368632#ENSG00000107485#ENST00000379328#GATA# FALSE 1195 ENSG00000136574 GATA4 GATA Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000679;IPR008013;IPR016375; 2626 GATA binding protein 4 [Source:HGNC Symbol;Acc:HGNC:4173] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:8455608 Yes 1a1, Direct HQ evidence Arttu Jolma Jussi Taipale Yes $#ENSG00000136574#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IBA - GO_REF:0000033$#ENSG00000136574#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:9312027 $#ENSP00000435712#ENSG00000136574#ENST00000532059#GATA#GATA-N$#ENSP00000473671#ENSG00000136574#ENST00000532977#GATA#GATA-N$#ENSP00000473598#ENSG00000136574#ENST00000526974#GATA#GATA-N$#ENSP00000432278#ENSG00000136574#ENST00000528027#GATA#GATA-N$#ENSP00000435043#ENSG00000136574#ENST00000528712#GATA# FALSE 1196 ENSG00000130700 GATA5 GATA Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000679;IPR008013;IPR016375; 140628 GATA binding protein 5 [Source:HGNC Symbol;Acc:HGNC:15802] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:10212267;11408257 Yes 1a1, Direct HQ evidence Pratyush Das Laura Campitelli Yes $#ENSG00000130700#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IBA - GO_REF:0000033$#ENSG00000130700#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:14986113$#ENSG00000130700#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019 $#ENSP00000252997#ENSG00000130700#ENST00000252997#GATA#GATA-N FALSE 1197 ENSG00000141448 GATA6 GATA Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000679;IPR008013 2627 GATA binding protein 6 [Source:HGNC Symbol;Acc:HGNC:4174] None DBD Yes None None a Yes TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:14988427 Yes 1a1, Direct HQ evidence Yimeng Yin Matt Weirauch Yes $#ENSG00000141448#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IMP - PMID:21127043$#ENSG00000141448#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IBA - GO_REF:0000033$#ENSG00000141448#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:19666519$#ENSG00000141448#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019 $#ENSP00000269216#ENSG00000141448#ENST00000269216#GATA#GATA-N$#ENSP00000462313#ENSG00000141448#ENST00000581694#GATA#GATA-N FALSE 1198 ENSG00000157259 GATAD1 GATA No Unlikely to be sequence specific TF Not a DNA binding protein No motif None The GATA domain is truncated (see alignment) IPR000679; 57798 GATA zinc finger domain containing 1 [Source:HGNC Symbol;Acc:HGNC:29941] None not tested not tested None None c Yes No No 4a, two or more datasets predict it as a TF Sam Lambert Laura Campitelli Yes $#ENSG00000157259#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002 $#ENSP00000287957#ENSG00000157259#ENST00000287957#GATA# FALSE 1199 ENSG00000167491 GATAD2A GATA Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Has the full GATA domain, and JPRED4 thinks the secondary structure is preserved. The GATA domain is not sufficiently well studied to declare that specific amino acids are absolutely required in order to bind DNA. Many unusual GATA domain proteins across eukaryotes bind DNA, making it reasonable to project that this one does, too. IPR000679; 54815 GATA zinc finger domain containing 2A [Source:HGNC Symbol;Acc:HGNC:29989] None not tested not tested None PMID:12183469 shows that this protein interacts strongly with MBD2 and MBD3 in silencing x Yes No No 4a, two or more datasets predict it as a TF Yimeng Yin Jussi Taipale Yes $#ENSG00000167491#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002 $#ENSP00000351552#ENSG00000167491#ENST00000358713#GATA#P66_CC$#ENSP00000384899#ENSG00000167491#ENST00000404158#GATA#P66_CC$#ENSP00000403703#ENSG00000167491#ENST00000417582#GATA#P66_CC$#ENSP00000404212#ENSG00000167491#ENST00000457895#GATA#P66_CC$#ENSP00000477171#ENSG00000167491#ENST00000494516#GATA#$#ENSP00000414252#ENSG00000167491#ENST00000429242#GATA# FALSE 1200 ENSG00000143614 GATAD2B GATA Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Has the full GATA domain, and JPRED4 thinks the secondary structure is preserved. The GATA domain is not sufficiently well studied to declare that specific amino acids are absolutely required in order to bind DNA. Many unusual GATA domain proteins across eukaryotes bind DNA, making it reasonable to project that this one does, too. IPR000679; 57459 GATA zinc finger domain containing 2B [Source:HGNC Symbol;Acc:HGNC:30778] None not tested Yes None PMID:12183469 shows that this protein interacts strongly with MBD2 and MBD3 in silencing x Yes TF Gene_Transcription Regulatory Activity: heterochromatin interaction/binding_TF PPI_PMIDS:12183469;16415179 No 4a, two or more datasets predict it as a TF Sam Lambert Jussi Taipale No $#ENSG00000143614#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002 $#ENSP00000357644#ENSG00000143614#ENST00000368655#GATA#P66_CC$#ENSP00000489566#ENSG00000143614#ENST00000634791#GATA#$#ENSP00000490635#ENSG00000143614#ENST00000637331#GATA#$#ENSP00000490724#ENSG00000143614#ENST00000637918#GATA# FALSE 1201 ENSG00000104447 TRPS1 GATA Yes Known motif Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain None IPR000679;IPR007087;IPR015880; 7227 transcriptional repressor GATA binding 1 [Source:HGNC Symbol;Acc:HGNC:12340] None Full not tested None None a Yes TF Gene Candidate_DNA-Binding: sequence-specific_Other_PMIDS:10615131;11112658;12761050 Yes 2a1, Lower confidence direct evidence Laura Campitelli Sam Lambert Yes $#ENSG00000104447#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IBA - GO_REF:0000033$#ENSG00000104447#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:10615131 $#ENSP00000220888#ENSG00000104447#ENST00000220888#GATA#zf-H2C2_5$#ENSP00000379065#ENSG00000104447#ENST00000395715#GATA#zf-H2C2_5$#ENSP00000429174#ENSG00000104447#ENST00000519674#GATA#Actin_micro, zf-H2C2_5$#ENSP00000405028#ENSG00000104447#ENST00000422939#GATA#$#ENSP00000428121#ENSG00000104447#ENST00000518018#GATA#$#ENSP00000428680#ENSG00000104447#ENST00000520276#GATA#zf-H2C2_5$#ENSP00000379063#ENSG00000104447#ENST00000395713#GATA#$#ENSP00000430383#ENSG00000104447#ENST00000519815#GATA# FALSE 1202 ENSG00000220201 ZGLP1 GATA Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR000679; 100125288 zinc finger, GATA-like protein 1 [Source:HGNC Symbol;Acc:HGNC:37245] None DBD not tested None Taipale Lab, Unpublished HT-SELEX, direct a Yes No Yes 1a1, Direct HQ evidence Jussi Taipale Pratyush Das Yes $#ENSG00000220201#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IBA - GO_REF:0000033 $#ENSP00000384434#ENSG00000220201#ENST00000403903#GATA#$#ENSP00000385403#ENSG00000220201#ENST00000403352#GATA# FALSE 1203 ENSG00000137270 GCM1 GCM Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR003902; 8521 glial cells missing homolog 1 [Source:HGNC Symbol;Acc:HGNC:4197] 1ODH DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:12682016;15385555 Yes 1a1, Direct HQ evidence Arttu Jolma Pratyush Das Yes $#ENSG00000137270#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IDA - PMID:23867755$#ENSG00000137270#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:15385555$#ENSG00000137270#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:15385555 $#ENSP00000259803#ENSG00000137270#ENST00000259803#GCM# FALSE 1204 ENSG00000124827 GCM2 GCM Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR003902; 9247 glial cells missing homolog 2 [Source:HGNC Symbol;Acc:HGNC:4198] None DBD and Full not tested None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:10671510 Yes 1a1, Direct HQ evidence Pratyush Das Jussi Taipale Yes $#ENSG00000124827#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IBA - GO_REF:0000033 $#ENSP00000368805#ENSG00000124827#ENST00000379491#GCM# FALSE 1205 ENSG00000134317 GRHL1 Grainyhead Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR007604; 29841 grainyhead like transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:17923] None DBD and Full not tested None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:12175488 Yes 1a1, Direct HQ evidence Matt Weirauch Jussi Taipale Yes $#ENSG00000134317#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:12175488 $#ENSP00000324693#ENSG00000134317#ENST00000324907#CP2#$#ENSP00000384209#ENSG00000134317#ENST00000405379#CP2#$#ENSP00000419831#ENSG00000134317#ENST00000480736#CP2# FALSE 1206 ENSG00000083307 GRHL2 Grainyhead Yes Known motif Monomer or homomultimer In vivo/Misc source None None IPR007604; 79977 grainyhead like transcription factor 2 [Source:HGNC Symbol;Acc:HGNC:2799] None DBD and Full Yes None PMID: 25758223, binds similar sites as GRHL1 in ChIP-seq a Yes Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0 Yes 1a1, Direct HQ evidence Arttu Jolma Laura Campitelli Yes $#ENSG00000083307#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IDA - PMID:23814079$#ENSG00000083307#GO:0003700#sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024 $#ENSP00000251808#ENSG00000083307#ENST00000251808#CP2#$#ENSP00000379260#ENSG00000083307#ENST00000395927#CP2#$#ENSP00000430473#ENSG00000083307#ENST00000521085#CP2# FALSE 1207 ENSG00000158055 GRHL3 Grainyhead Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Binds the same AACCGGTT consensus as the paralog GRHL1 based on SELEX (PMID: 21081122). IPR007604; 57822 grainyhead like transcription factor 3 [Source:HGNC Symbol;Acc:HGNC:25839] None DBD and Full not tested None None a Yes TF Gene Candidate_DNA-Binding: sequence-specific_Transactivation_PMIDS:12549979;15831758 Yes 3a, decent circumstantial evidence for its role as Sam Lambert Arttu Jolma Yes $#ENSG00000158055#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IDA - PMID:23685552 $#ENSP00000236255#ENSG00000158055#ENST00000236255#CP2#$#ENSP00000348333#ENSG00000158055#ENST00000356046#CP2#$#ENSP00000354943#ENSG00000158055#ENST00000361548#CP2#$#ENSP00000288955#ENSG00000158055#ENST00000350501#CP2# FALSE 1208 ENSG00000135457 TFCP2 Grainyhead Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR007604;IPR013761 7024 transcription factor CP2 [Source:HGNC Symbol;Acc:HGNC:11748] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:15232220 Yes 1a1, Direct HQ evidence Yimeng Yin Matt Weirauch Yes $#ENSG00000135457#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:8157699 $#ENSP00000257915#ENSG00000135457#ENST00000257915#CP2#$#ENSP00000449280#ENSG00000135457#ENST00000548108#CP2#$#ENSP00000447991#ENSG00000135457#ENST00000548115#CP2#$#ENSP00000449742#ENSG00000135457#ENST00000549867#CP2# FALSE 1209 ENSG00000115112 TFCP2L1 Grainyhead Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR007604;IPR013761 29842 transcription factor CP2-like 1 [Source:HGNC Symbol;Acc:HGNC:17925] None DBD and Full not tested None None a Yes No Yes 1a1, Direct HQ evidence Matt Weirauch Arttu Jolma Yes $#ENSG00000115112#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:10644752 $#ENSP00000263707#ENSG00000115112#ENST00000263707#CP2# FALSE 1210 ENSG00000153560 UBP1 Grainyhead Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR007604;IPR013761 7342 upstream binding protein 1 (LBP-1a) [Source:HGNC Symbol;Acc:HGNC:12507] None DBD Yes None None a Yes TF Gene_Transcription Factor Binding: tf co-factor binding_Co-activation_PMIDS:15988015 Yes 1a1, Direct HQ evidence Sam Lambert Yimeng Yin Yes $#ENSG00000153560#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:8114710 $#ENSP00000283629#ENSG00000153560#ENST00000283629#CP2#$#ENSP00000283628#ENSG00000153560#ENST00000283628#CP2#$#ENSP00000395558#ENSG00000153560#ENST00000447368#CP2#$#ENSP00000401614#ENSG00000153560#ENST00000456378#CP2# FALSE 1211 ENSG00000263001 GTF2I GTF2I-like Yes Known motif Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain (PMID: 18326499) shows through SELEX and EMSA that this family binds DNA specifically. Transfac motifs are dubious. IPR004212;IPR016659 2969 general transcription factor IIi [Source:HGNC Symbol;Acc:HGNC:4659] None not tested not tested None None No Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:8662630;17052463 Yes 2a1, Lower confidence direct evidence Arttu Jolma Jussi Taipale No $#ENSG00000263001#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000263001#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:9334314 $#ENSP00000404240#ENSG00000263001#ENST00000443166#GTF2I#$#ENSP00000460070#ENSG00000263001#ENST00000573035#GTF2I#$#ENSP00000484526#ENSG00000263001#ENST00000614986#GTF2I#$#ENSP00000477837#ENSG00000263001#ENST00000620879#GTF2I#$#ENSP00000482476#ENSG00000263001#ENST00000621734#GTF2I# FALSE 1212 ENSG00000006704 GTF2IRD1 GTF2I-like Yes Known motif Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain (PMID: 18326499) shows through SELEX and EMSA that this family binds DNA specifically. Transfac motifs are dubious. V$BEN_02 motif has partial similarity to a shift-experiment sequence (PMID:14645227), which shows DNA-binding and evidence of transcriptional regulation by knockdown experiments IPR004212;IPR016659 9569 GTF2I repeat domain containing 1 [Source:HGNC Symbol;Acc:HGNC:4661] None DBD and Full not tested None None No Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:14645227 Yes 2a1, Lower confidence direct evidence Sam Lambert Arttu Jolma No $#ENSG00000006704#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000006704#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:10575229$#ENSG00000006704#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#NAS - PMID:9774679 $#ENSP00000265755#ENSG00000006704#ENST00000265755#GTF2I#$#ENSP00000408477#ENSG00000006704#ENST00000424337#GTF2I#$#ENSP00000397566#ENSG00000006704#ENST00000455841#GTF2I#$#ENSP00000418383#ENSG00000006704#ENST00000476977#GTF2I#$#ENSP00000417909#ENSG00000006704#ENST00000470715#GTF2I# FALSE 1213 ENSG00000196275 GTF2IRD2 GTF2I-like Yes Likely to be sequence specific TF Monomer or homomultimer No motif None (PMID: 18326499) shows through SELEX and EMSA that this family binds DNA specifically. IPR004212;IPR012337 84163 GTF2I repeat domain containing 2 [Source:HGNC Symbol;Acc:HGNC:30775] None not tested Yes None None x Yes No No 4a, two or more datasets predict it as a TF Sam Lambert Arttu Jolma No None $#ENSP00000406723#ENSG00000196275#ENST00000451013#GTF2I#DUF4371, Med25_NR-box$#ENSP00000481017#ENSG00000196275#ENST00000614386#GTF2I#$#ENSP00000486581#ENSG00000196275#ENST00000625377#GTF2I# FALSE 1214 ENSG00000174428 GTF2IRD2B GTF2I-like Yes Likely to be sequence specific TF Monomer or homomultimer No motif None (PMID: 18326499) shows through SELEX and EMSA that this family binds DNA specifically. IPR004212;IPR012337 389524 GTF2I repeat domain containing 2B [Source:HGNC Symbol;Acc:HGNC:33125] None Full not tested None None x Yes Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0 Yes 4a, two or more datasets predict it as a TF Yimeng Yin Arttu Jolma No $#ENSG00000174428#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000480524#ENSG00000174428#ENST00000472837#GTF2I#DUF4371, Med25_NR-box$#ENSP00000481706#ENSG00000174428#ENST00000614064#GTF2I#$#ENSP00000480037#ENSG00000174428#ENST00000619142#GTF2I#$#ENSP00000486360#ENSG00000174428#ENST00000629105#GTF2I# FALSE 1215 ENSG00000258724 AC105001.2 HMG/Sox No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Unlikely to be sequence specific TF - it has a deletion inside the SOX-domain removing several residues that contact DNA based on the structure of paralog SOX17. IPR000467;IPR009071;IPR021934 None CTD-2135J3.4 None not tested not tested None None No Yes No No 5a, one of the source datasets predicts is as a TF Pratyush Das Arttu Jolma No None $#ENSP00000451145#ENSG00000258724#ENST00000554914#HMG#G-patch, G-patch_2, Sox17_18_mid FALSE 1216 ENSG00000114439 BBX HMG/Sox Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR009071;IPR019102 56987 BBX, HMG-box containing [Source:HGNC Symbol;Acc:HGNC:14422] None DBD and Full Yes None None b Yes No No 1a1, Direct HQ evidence Pratyush Das Matt Weirauch Yes None $#ENSP00000319974#ENSG00000114439#ENST00000325805#HMG#DUF2028$#ENSP00000408358#ENSG00000114439#ENST00000415149#HMG#DUF2028$#ENSP00000403860#ENSG00000114439#ENST00000416476#HMG#DUF2028$#ENSP00000400543#ENSG00000114439#ENST00000456817#HMG# FALSE 1217 ENSG00000007080 CCDC124 HMG/Sox No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None Based on the alignment, it lacks a proper HMG domain. Evidence it binds RNA (PMID: 22658674). IPR010422; 115098 coiled-coil domain containing 124 [Source:HGNC Symbol;Acc:HGNC:25171] None not tested not tested None None No Yes No No 5a, one of the source datasets predicts is as a TF Yimeng Yin Laura Campitelli No None $#ENSP00000471455#ENSG00000007080#ENST00000597436#HMG#$#ENSP00000408730#ENSG00000007080#ENST00000445755#HMG#$#ENSP00000472520#ENSG00000007080#ENST00000596123#HMG# FALSE 1218 ENSG00000170004 CHD3 HMG/Sox No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif Has a putative AT-hook No evidence for sequence-specific DNA-binding in the literature; and contains only a partial match to an HMG box with no similarity to DBDs of other CHD family proteins IPR000330;IPR000953;IPR001650;IPR001965;IPR002464;IPR009071;IPR009462;IPR009463;IPR011011;IPR012957;IPR012958; 1107 chromodomain helicase DNA binding protein 3 [Source:HGNC Symbol;Acc:HGNC:1918] None not tested not tested None None No Yes No No 5a, one of the source datasets predicts is as a TF Sam Lambert Laura Campitelli No None $#ENSP00000332628#ENSG00000170004#ENST00000330494#HMG#CHDCT2, Chromo, DEAD, DUF1086, DUF1087, HDA2-3, He$#ENSP00000350907#ENSG00000170004#ENST00000358181#HMG#CHDCT2, Chromo, DEAD, DUF1086, DUF1087, HDA2-3, He$#ENSP00000369716#ENSG00000170004#ENST00000380358#HMG#CHDCT2, Chromo, DEAD, DUF1086, DUF1087, HDA2-3, He$#ENSP00000411959#ENSG00000170004#ENST00000449744#HMG#CHDCT2$#ENSP00000458861#ENSG00000170004#ENST00000571249#HMG#$#ENSP00000459321#ENSG00000170004#ENST00000573936#HMG#CHDCT2 FALSE 1219 ENSG00000111642 CHD4 HMG/Sox No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None CHD4 is likely not a sequence-specific DNA-binding protein despite having a partial match to an HMG box. This protein binds to the DNA backbone, but binds poly(ADP-ribose) with higher affinity (PMID: 26565020). IPR000330;IPR000953;IPR001650;IPR001965;IPR002464;IPR009462;IPR009463;IPR011011;IPR012957;IPR012958;IPR014001; 1108 chromodomain helicase DNA binding protein 4 [Source:HGNC Symbol;Acc:HGNC:1919] None not tested not tested None None No Yes No No 5a, one of the source datasets predicts is as a TF Sam Lambert Pratyush Das No None $#ENSP00000349508#ENSG00000111642#ENST00000357008#HMG#CHDCT2, Chromo, DUF1086, DUF1087, HDA2-3, Helicase$#ENSP00000437506#ENSG00000111642#ENST00000545942#HMG#CHDNT$#ENSP00000440392#ENSG00000111642#ENST00000544484#HMG#CHDCT2, Chromo, DUF1086, DUF1087, HDA2-3, Helicase$#ENSP00000444614#ENSG00000111642#ENST00000545584#HMG# FALSE 1220 ENSG00000079432 CIC HMG/Sox Yes Known motif Monomer or homomultimer 100 perc ID - in vitro None None IPR009071; 23152 capicua transcriptional repressor [Source:HGNC Symbol;Acc:HGNC:14214] None DBD not tested None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:16717057 No 1a1, Direct HQ evidence Sam Lambert Pratyush Das Yes None $#ENSP00000458663#ENSG00000079432#ENST00000575354#HMG#$#ENSP00000458543#ENSG00000079432#ENST00000573349#HMG#$#ENSP00000459011#ENSG00000079432#ENST00000576505#HMG# FALSE 1221 ENSG00000105856 HBP1 HMG/Sox Yes Known motif Monomer or homomultimer 100 perc ID - in vitro None None IPR003652;IPR009071;IPR013723; 26959 HMG-box transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:23200] None DBD and Full Yes None None a Yes No No 1a1, Direct HQ evidence Tim Hughes Sam Lambert Yes None $#ENSP00000222574#ENSG00000105856#ENST00000222574#HMG#AXH$#ENSP00000420500#ENSG00000105856#ENST00000468410#HMG#AXH$#ENSP00000417927#ENSG00000105856#ENST00000479011#HMG#$#ENSP00000418738#ENSG00000105856#ENST00000485846#HMG#AXH$#ENSP00000417631#ENSG00000105856#ENST00000497535#HMG#$#ENSP00000418017#ENSG00000105856#ENST00000498408#HMG#AXH$#ENSP00000475809#ENSG00000105856#ENST00000607681#HMG# FALSE 1222 ENSG00000140382 HMG20A HMG/Sox Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Similar to HMG20B, which has an inferred motif from mouse. IPR009071; 10363 high mobility group 20A [Source:HGNC Symbol;Acc:HGNC:5001] None not tested not tested None None x Yes No Yes 4a, two or more datasets predict it as a TF Matt Weirauch Sam Lambert Yes $#ENSG00000140382#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:10773667 $#ENSP00000336856#ENSG00000140382#ENST00000336216#HMG#DUF4763$#ENSP00000371133#ENSG00000140382#ENST00000381714#HMG#DUF4763$#ENSP00000452847#ENSG00000140382#ENST00000558845#HMG#DUF4763, IncA, Trans_reg_C$#ENSP00000452665#ENSG00000140382#ENST00000558176#HMG# FALSE 1223 ENSG00000064961 HMG20B HMG/Sox Yes Inferred motif Monomer or homomultimer High-throughput in vitro None None IPR009071; 10362 high mobility group 20B [Source:HGNC Symbol;Acc:HGNC:5002] None not tested not tested None None x Yes No No 1a1, Direct HQ evidence Jussi Taipale Matt Weirauch Yes None $#ENSP00000328269#ENSG00000064961#ENST00000333651#HMG#$#ENSP00000402877#ENSG00000064961#ENST00000453933#HMG#$#ENSP00000410924#ENSG00000064961#ENST00000416526#HMG#$#ENSP00000465293#ENSG00000064961#ENST00000585900#HMG#IncA FALSE 1224 ENSG00000189403 HMGB1 HMG/Sox No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None In the alignment, it clusters with other HMG proteins that have not yielded motifs. Evidence exists showing HMGB1/2 are non-sequence-specific binding proteins (PMID: 11497996). IPR009071;IPR017967 3146 high mobility group box 1 [Source:HGNC Symbol;Acc:HGNC:4983] 1CKT not tested not tested None The structure is with interstrand crosslinked DNA x Yes No Yes 3a, decent circumstantial evidence for its role as Sam Lambert Jussi Taipale No $#ENSG00000189403#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:19223331 $#ENSP00000345347#ENSG00000189403#ENST00000341423#HMG#$#ENSP00000382412#ENSG00000189403#ENST00000399489#HMG#$#ENSP00000343040#ENSG00000189403#ENST00000339872#HMG#$#ENSP00000382417#ENSG00000189403#ENST00000399494#HMG#$#ENSP00000384678#ENSG00000189403#ENST00000405805#HMG#$#ENSP00000369904#ENSG00000189403#ENST00000326004#HMG# FALSE 1225 ENSG00000164104 HMGB2 HMG/Sox No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None In the alignment, it clusters with other HMG proteins that have not yielded motifs. Evidence exists showing HMGB1/2 are non-sequence-specific binding proteins (PMID: 11497996). HMGB2 is well-known to facilitate DNA-bending and interact with sequence-specific TFs and transcriptional co-factors. IPR009071;IPR017967 3148 high mobility group box 2 [Source:HGNC Symbol;Acc:HGNC:5000] None not tested not tested None None x Yes TF Gene_Transcription Factor Binding: tf co-factor binding; DNA-Binding: non-sequence-specific_Non-specific DNA_PMIDS:9888798;11748232;12517784 Yes 4a, two or more datasets predict it as a TF Sam Lambert Yimeng Yin No $#ENSG00000164104#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:19223331 $#ENSP00000296503#ENSG00000164104#ENST00000296503#HMG#$#ENSP00000404912#ENSG00000164104#ENST00000438704#HMG#$#ENSP00000393448#ENSG00000164104#ENST00000446922#HMG#$#ENSP00000423001#ENSG00000164104#ENST00000506267#HMG# FALSE 1226 ENSG00000029993 HMGB3 HMG/Sox No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None Similar to HMGB1/2, which bind DNA with low specificity IPR009071;IPR017967 3149 high mobility group box 3 [Source:HGNC Symbol;Acc:HGNC:5004] None Full not tested None None x Yes No No 4a, two or more datasets predict it as a TF Yimeng Yin Pratyush Das No None $#ENSP00000359393#ENSG00000029993#ENST00000325307#HMG#$#ENSP00000417027#ENSG00000029993#ENST00000430118#HMG#$#ENSP00000442758#ENSG00000029993#ENST00000448905#HMG#$#ENSP00000405601#ENSG00000029993#ENST00000455596#HMG#$#ENSP00000410354#ENSG00000029993#ENST00000419110#HMG# FALSE 1227 ENSG00000176256 HMGB4 HMG/Sox No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None Similar to HMGB1/2, which bind DNA with low specificity. Yet, it can also bind with 4.35nM affinity to DNA containing an intra-strand crosslink made by cis-platin (PMID: 22901013). IPR009071; 127540 high mobility group box 4 [Source:HGNC Symbol;Acc:HGNC:24954] None Full not tested None None x Yes No No 4a, two or more datasets predict it as a TF Pratyush Das Arttu Jolma No None $#ENSP00000429214#ENSG00000176256#ENST00000519684#HMG#$#ENSP00000430919#ENSG00000176256#ENST00000522796#HMG# FALSE 1228 ENSG00000205581 HMGN1 HMG/Sox No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None In the alignment, it clusters with other HMG proteins that have not yielded motifs. IPR000079 3150 high mobility group nucleosome binding domain 1 [Source:HGNC Symbol;Acc:HGNC:4984] None not tested not tested None None No No TF Gene Candidate_Transcription Regulatory Activity: heterochromatin interaction/binding_Other_PMIDS:8524231;16382150 No 5a, one of the source datasets predicts is as a TF Pratyush Das Yimeng Yin No None $##ENSG00000205581##Other# FALSE 1229 ENSG00000118418 HMGN3 HMG/Sox Yes Likely to be sequence specific TF Low specificity DNA-binding protein No motif None None IPR000079 9324 high mobility group nucleosomal binding domain 3 [Source:HGNC Symbol;Acc:HGNC:12312] None not tested not tested None None No No TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_Other_PMIDS:7776974;11356838;15082770 No 5a, one of the source datasets predicts is as a TF Pratyush Das Jussi Taipale No None $##ENSG00000118418##Other# FALSE 1230 ENSG00000113716 HMGXB3 HMG/Sox No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None In the alignment, it clusters with other HMG proteins that have not yielded motifs. IPR009071; 22993 HMG-box containing 3 [Source:HGNC Symbol;Acc:HGNC:28982] None not tested not tested None None x Yes No No 4a, two or more datasets predict it as a TF Tim Hughes Yimeng Yin Yes None $#ENSP00000421917#ENSG00000113716#ENST00000502717#HMG#$#ENSP00000422231#ENSG00000113716#ENST00000503427#HMG#$#ENSP00000479027#ENSG00000113716#ENST00000613459#HMG# FALSE 1231 ENSG00000100281 HMGXB4 HMG/Sox No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None In the alignment, it clusters with other HMG proteins that have not yielded motifs. IPR009071;IPR025228 10042 HMG-box containing 4 [Source:HGNC Symbol;Acc:HGNC:5003] None not tested not tested None None x Yes No No 4a, two or more datasets predict it as a TF Arttu Jolma Pratyush Das Yes None $#ENSP00000415500#ENSG00000100281#ENST00000455359#HMG#DUF4171$#ENSP00000401658#ENSG00000100281#ENST00000420166#HMG#DUF4171$#ENSP00000216106#ENSG00000100281#ENST00000216106#HMG#DUF4171 FALSE 1232 ENSG00000055609 KMT2C HMG/Sox No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif Has a putative AT-hook Based on the alignment, it is quite different from all other HMG proteins. It is borderline to say that it is a HMG at all. IPR000637;IPR001214;IPR001594;IPR001841;IPR001965;IPR003616;IPR003888;IPR003889;IPR009071;IPR011011;IPR019787; 58508 lysine methyltransferase 2C [Source:HGNC Symbol;Acc:HGNC:13726] None not tested not tested None None x Yes No No 4a, two or more datasets predict it as a TF Laura Campitelli Matt Weirauch No None $#ENSP00000262189#ENSG00000055609#ENST00000262189#HMG#FYRC, FYRN, PHD, SET, zf-HC5HC2H, zf-HC5HC2H_2$#ENSP00000347325#ENSG00000055609#ENST00000355193#HMG#FYRC, FYRN, PHD, SET, zf-HC5HC2H, zf-HC5HC2H_2$#ENSP00000353218#ENSG00000055609#ENST00000360104#HMG#FYRC, FYRN, SET, zf-HC5HC2H, zf-HC5HC2H_2$#ENSP00000454058#ENSG00000055609#ENST00000558665#HMG# FALSE 1233 ENSG00000167548 KMT2D HMG/Sox No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None Based on alignment it is quite different from all other HMG proteins, borderline to say if it is a HMG at all. Crystal structure has an aminoacid sequence that doesnt match to the protein it claims to be IPR001214;IPR001841;IPR001965;IPR003616;IPR003888;IPR003889;IPR009071;IPR011011;IPR019787; 8085 lysine methyltransferase 2D [Source:HGNC Symbol;Acc:HGNC:7133] 4PZI not tested not tested None Crystal structure is with a CpG containing DNA c Yes No No 3a, decent circumstantial evidence for its role as Arttu Jolma Jussi Taipale No None $#ENSP00000435714#ENSG00000167548#ENST00000526209#HMG#SET$#ENSP00000301067#ENSG00000167548#ENST00000301067#HMG#FYRC, FYRN, PHD, SET, zf-HC5HC2H, zf-HC5HC2H_2$#ENSP00000449455#ENSG00000167548#ENST00000547610#HMG# FALSE 1234 ENSG00000138795 LEF1 HMG/Sox Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR009071;IPR013558 51176 lymphoid enhancer binding factor 1 [Source:HGNC Symbol;Acc:HGNC:6551] 2LEF DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_TF PPI_PMIDS:10958684;11696550;14579381 Yes 1a1, Direct HQ evidence Yimeng Yin Pratyush Das Yes $#ENSG00000138795#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000138795#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IMP - PMID:23001182$#ENSG00000138795#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:11751639$#ENSG00000138795#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000265165#ENSG00000138795#ENST00000265165#HMG#CTNNB1_binding$#ENSP00000369284#ENSG00000138795#ENST00000379951#HMG#CTNNB1_binding$#ENSP00000406176#ENSG00000138795#ENST00000438313#HMG#CTNNB1_binding$#ENSP00000422840#ENSG00000138795#ENST00000510624#HMG#CTNNB1_binding$#ENSP00000427365#ENSG00000138795#ENST00000512172#HMG#CTNNB1_binding$#ENSP00000422801#ENSG00000138795#ENST00000515500#HMG#CTNNB1_binding FALSE 1235 ENSG00000143194 MAEL HMG/Sox No ssDNA/RNA binding Not a DNA binding protein No motif None Orthologous protein from mouse binds RNA (PMID: 25807393) IPR009071;IPR024970 84944 maelstrom spermatogenic transposon silencer [Source:HGNC Symbol;Acc:HGNC:25929] None DBD not tested None None a Yes No No 4a, two or more datasets predict it as a TF Sam Lambert Arttu Jolma No None $#ENSP00000356844#ENSG00000143194#ENST00000367870#HMG#HMG_box_2, Maelstrom$#ENSP00000356846#ENSG00000143194#ENST00000367872#HMG#Maelstrom$#ENSP00000482771#ENSG00000143194#ENST00000622874#HMG#Maelstrom$#ENSP00000402143#ENSG00000143194#ENST00000447624#HMG#HMG_box_2, Maelstrom FALSE 1236 ENSG00000109685 NSD2 HMG/Sox No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None Likely affects transcription by histone modification (not specific DNA-binding). IPR000313;IPR001214;IPR001841;IPR001965;IPR003616;IPR006560;IPR009071;IPR011011;IPR019786;IPR019787 7468 Wolf-Hirschhorn syndrome candidate 1 [Source:HGNC Symbol;Acc:HGNC:12766] None DBD not tested None Its a histone methyltransferase, not likely to have any sequence specificity a Yes No No 3a, decent circumstantial evidence for its role as Laura Campitelli Yimeng Yin Yes None $#ENSP00000372344#ENSG00000109685#ENST00000382888#HMG#PHD, PWWP, SET$#ENSP00000372348#ENSG00000109685#ENST00000382892#HMG#PHD, PWWP, SET, zf-HC5HC2H$#ENSP00000372351#ENSG00000109685#ENST00000382895#HMG#PHD, PWWP, SET, zf-HC5HC2H$#ENSP00000381311#ENSG00000109685#ENST00000398261#HMG#PWWP$#ENSP00000399251#ENSG00000109685#ENST00000420906#HMG#PWWP$#ENSP00000416725#ENSG00000109685#ENST00000436793#HMG#PWWP$#ENSP00000425761#ENSG00000109685#ENST00000503128#HMG#PWWP$#ENSP00000423972#ENSG00000109685#ENST00000508803#HMG#PHD, PWWP, SET, zf-HC5HC2H$#ENSP00000421681#ENSG00000109685#ENST00000514045#HMG#PWWP$#ENSP00000422878#ENSG00000109685#ENST00000509115#HMG#PWWP$#ENSP00000425094#ENSG00000109685#ENST00000514329#HMG#PHD, PHD_2, PWWP$#ENSP00000427434#ENSG00000109685#ENST00000515806#HMG# FALSE 1237 ENSG00000163939 PBRM1 HMG/Sox No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None (PMID: 23867514) shows it may bind nucleosomal DNA. IPR001025;IPR001487;IPR009071;IPR018359 55193 polybromo 1 [Source:HGNC Symbol;Acc:HGNC:30064] None Full not tested None None x Yes TF Gene Candidate_Transcription Regulatory Activity: heterochromatin interaction/binding_DNA Binding_PMIDS:11078522;15601824 No 4a, two or more datasets predict it as a TF Arttu Jolma Pratyush Das Yes None $#ENSP00000296302#ENSG00000163939#ENST00000296302#HMG#BAH, Bromodomain$#ENSP00000338302#ENSG00000163939#ENST00000337303#HMG#BAH, Bromodomain$#ENSP00000349213#ENSG00000163939#ENST00000356770#HMG#BAH, Bromodomain$#ENSP00000378307#ENSG00000163939#ENST00000394830#HMG#BAH, Bromodomain$#ENSP00000386593#ENSG00000163939#ENST00000409057#HMG#BAH, Bromodomain$#ENSP00000386643#ENSG00000163939#ENST00000409114#HMG#BAH, Bromodomain$#ENSP00000386601#ENSG00000163939#ENST00000409767#HMG#BAH, Bromodomain$#ENSP00000386529#ENSG00000163939#ENST00000410007#HMG#BAH, Bromodomain$#ENSP00000397662#ENSG00000163939#ENST00000446103#HMG#BAH, Bromodomain$#ENSP00000389390#ENSG00000163939#ENST00000420148#HMG#Bromodomain$#ENSP00000412401#ENSG00000163939#ENST00000449505#HMG#Bromodomain$#ENSP00000411895#ENSG00000163939#ENST00000458294#HMG# FALSE 1238 ENSG00000064933 PMS1 HMG/Sox No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None In the alignment, it clusters with other HMG proteins that have not yielded motifs. IPR002099;IPR003594;IPR009071;IPR013507;IPR014762;IPR020568 5378 PMS1 homolog 1, mismatch repair system component [Source:HGNC Symbol;Acc:HGNC:9121] None Full not tested None None x Yes No No 4a, two or more datasets predict it as a TF Tim Hughes Pratyush Das No None $#ENSP00000363959#ENSG00000064933#ENST00000374826#HMG#HATPase_c, HATPase_c_3$#ENSP00000387169#ENSG00000064933#ENST00000409593#HMG#DNA_mis_repair$#ENSP00000406490#ENSG00000064933#ENST00000441310#HMG#DNA_mis_repair, HATPase_c, HATPase_c_3$#ENSP00000386623#ENSG00000064933#ENST00000409985#HMG#HATPase_c, HATPase_c_3$#ENSP00000398378#ENSG00000064933#ENST00000432292#HMG#DNA_mis_repair$#ENSP00000401064#ENSG00000064933#ENST00000447232#HMG#DNA_mis_repair, HATPase_c, HATPase_c_3$#ENSP00000485312#ENSG00000064933#ENST00000624204#HMG#DNA_mis_repair$#ENSP00000391136#ENSG00000064933#ENST00000420421#HMG#HATPase_c, HATPase_c_3$#ENSP00000410082#ENSG00000064933#ENST00000424766#HMG#HATPase_c, HATPase_c_3 FALSE 1239 ENSG00000073584 SMARCE1 HMG/Sox No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None In the alignment, it clusters with other HMG proteins that have not yielded motifs. Contributes to SWI/SNF DNA-binding (PMID: 9435219). IPR009071;IPR009395 6605 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 [S None not tested not tested None None x Yes TF Gene_Transcription Factor Binding: tf co-factor binding_Co-activation; TF PPI_PMIDS:12145209;15743818 No 4a, two or more datasets predict it as a TF Laura Campitelli Sam Lambert Yes None $#ENSP00000323967#ENSG00000073584#ENST00000348513#HMG#GCN5L1$#ENSP00000367039#ENSG00000073584#ENST00000377808#HMG#GCN5L1$#ENSP00000411607#ENSG00000073584#ENST00000400122#HMG#GCN5L1$#ENSP00000463405#ENSG00000073584#ENST00000474246#HMG#$#ENSP00000464511#ENSG00000073584#ENST00000578044#HMG#GCN5L1$#ENSP00000462475#ENSG00000073584#ENST00000580419#HMG#GCN5L1$#ENSP00000445370#ENSG00000073584#ENST00000431889#HMG#GCN5L1$#ENSP00000466608#ENSG00000073584#ENST00000264640#HMG#GCN5L1$#ENSP00000392958#ENSG00000073584#ENST00000447024#HMG#GCN5L1 FALSE 1240 ENSG00000182968 SOX1 HMG/Sox Yes Known motif Monomer or homomultimer 100 perc ID - in vitro None None IPR009071;IPR022097 6656 SRY-box 1 [Source:HGNC Symbol;Acc:HGNC:11189] None DBD Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:9512512;11943779 Yes 1a1, Direct HQ evidence Pratyush Das Arttu Jolma Yes $#ENSG00000182968#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000182968#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:9337405 $#ENSP00000330218#ENSG00000182968#ENST00000330949#HMG#SOXp FALSE 1241 ENSG00000100146 SOX10 HMG/Sox Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR009071;IPR022151 6663 SRY-box 10 [Source:HGNC Symbol;Acc:HGNC:11190] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:15523643 No 1a1, Direct HQ evidence Tim Hughes Sam Lambert Yes $#ENSG00000100146#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019 $#ENSP00000354130#ENSG00000100146#ENST00000360880#HMG#Sox_N$#ENSP00000380093#ENSG00000100146#ENST00000396884#HMG#Sox_N$#ENSP00000399777#ENSG00000100146#ENST00000446929#HMG#$#ENSP00000414853#ENSG00000100146#ENST00000427770#HMG#Sox_N FALSE 1242 ENSG00000176887 SOX11 HMG/Sox Yes Known motif Monomer or homomultimer 100 perc ID - in vitro None None IPR009071; 6664 SRY-box 11 [Source:HGNC Symbol;Acc:HGNC:11191] None DBD Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:15183730 Yes 1a1, Direct HQ evidence Pratyush Das Sam Lambert Yes $#ENSG00000176887#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#ISS - GO_REF:0000024$#ENSG00000176887#GO:0003700#sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024 $#ENSP00000322568#ENSG00000176887#ENST00000322002#HMG# FALSE 1243 ENSG00000177732 SOX12 HMG/Sox Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR009071; 6666 SRY-box 12 [Source:HGNC Symbol;Acc:HGNC:11198] None DBD and Full Yes None None a Yes No Yes 1a1, Direct HQ evidence Sam Lambert Pratyush Das Yes $#ENSG00000177732#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#ISS - GO_REF:0000024 $#ENSP00000347646#ENSG00000177732#ENST00000342665#HMG# FALSE 1244 ENSG00000143842 SOX13 HMG/Sox Yes Known motif Monomer or homomultimer 100 perc ID - in vitro None None IPR009071; 9580 SRY-box 13 [Source:HGNC Symbol;Acc:HGNC:11192] None DBD Yes None None a Yes TF Gene Candidate__DNA Binding_PMIDS:9421502 Yes 1a1, Direct HQ evidence Jussi Taipale Yimeng Yin Yes $#ENSG00000143842#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:10198172 $#ENSP00000356172#ENSG00000143842#ENST00000367204#HMG#$#ENSP00000478239#ENSG00000143842#ENST00000618875#HMG#$#ENSP00000433595#ENSG00000143842#ENST00000525442#HMG#$#ENSP00000436297#ENSG00000143842#ENST00000528591#HMG# FALSE 1245 ENSG00000168875 SOX14 HMG/Sox Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR009071;IPR022097 8403 SRY-box 14 [Source:HGNC Symbol;Acc:HGNC:11193] None DBD and Full Yes None None a Yes Indeterminate - There is no evidence for or against this genes role as a TF__Other_PMIDS:10798354 No 1a1, Direct HQ evidence Sam Lambert Jussi Taipale Yes $#ENSG00000168875#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IEA - GO_REF:0000019 $#ENSP00000305343#ENSG00000168875#ENST00000306087#HMG#SOXp FALSE 1246 ENSG00000129194 SOX15 HMG/Sox Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR009071; 6665 SRY-box 15 [Source:HGNC Symbol;Acc:HGNC:11196] None DBD and Full Yes None None a Yes TF Gene Candidate_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:10821863 Yes 1a1, Direct HQ evidence Sam Lambert Pratyush Das Yes $#ENSG00000129194#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IEA - GO_REF:0000019$#ENSG00000129194#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:8332506 $#ENSP00000355354#ENSG00000129194#ENST00000250055#HMG#$#ENSP00000439311#ENSG00000129194#ENST00000538513#HMG#$#ENSP00000458286#ENSG00000129194#ENST00000570788#HMG# FALSE 1247 ENSG00000164736 SOX17 HMG/Sox Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR009071;IPR021934 64321 SRY-box 17 [Source:HGNC Symbol;Acc:HGNC:18122] 3F27 DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_Transactivation_PMIDS:15163629;15220343;15220343 Yes 1a1, Direct HQ evidence Laura Campitelli Arttu Jolma Yes $#ENSG00000164736#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IEA - GO_REF:0000019$#ENSG00000164736#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024 $#ENSP00000297316#ENSG00000164736#ENST00000297316#HMG#Sox17_18_mid FALSE 1248 ENSG00000203883 SOX18 HMG/Sox Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR009071;IPR021934 54345 SRY-box 18 [Source:HGNC Symbol;Acc:HGNC:11194] 4Y60 DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:12446692 Yes 1a1, Direct HQ evidence Jussi Taipale Laura Campitelli Yes $#ENSG00000203883#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:22292085 $#ENSP00000341815#ENSG00000203883#ENST00000340356#HMG#Sox17_18_mid FALSE 1249 ENSG00000181449 SOX2 HMG/Sox Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR009071;IPR022097 6657 SRY-box 2 [Source:HGNC Symbol;Acc:HGNC:11195] 1GT0 DBD and Full not tested None Structure is POU2F1 SOX2 heterodimer a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:15860457 Yes 1a1, Direct HQ evidence Pratyush Das Sam Lambert Yes $#ENSG00000181449#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000181449#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:16153702, PMID:18027866 | NAS - PMID:78 $#ENSP00000323588#ENSG00000181449#ENST00000325404#HMG#SOXp FALSE 1250 ENSG00000125285 SOX21 HMG/Sox Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR009071;IPR022097 11166 SRY-box 21 [Source:HGNC Symbol;Acc:HGNC:11197] None DBD Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:12446692 Yes 1a1, Direct HQ evidence Arttu Jolma Pratyush Das Yes $#ENSG00000125285#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#NAS - PMID:10441749$#ENSG00000125285#GO:0003700#sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024 $#ENSP00000366144#ENSG00000125285#ENST00000376945#HMG#SOXp FALSE 1251 ENSG00000134595 SOX3 HMG/Sox Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR009071;IPR022097 6658 SRY-box 3 [Source:HGNC Symbol;Acc:HGNC:11199] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:11875113;12710953 No 1a1, Direct HQ evidence Pratyush Das Laura Campitelli Yes $#ENSG00000134595#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002 $#ENSP00000359567#ENSG00000134595#ENST00000370536#HMG#SOXp FALSE 1252 ENSG00000039600 SOX30 HMG/Sox Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR009071; 11063 SRY-box 30 [Source:HGNC Symbol;Acc:HGNC:30635] None DBD and Full Yes None None a Yes No Yes 1a1, Direct HQ evidence Matt Weirauch Arttu Jolma Yes None $#ENSP00000265007#ENSG00000039600#ENST00000265007#HMG#$#ENSP00000309343#ENSG00000039600#ENST00000311371#HMG#$#ENSP00000427984#ENSG00000039600#ENST00000519442#HMG# FALSE 1253 ENSG00000124766 SOX4 HMG/Sox Yes Known motif Monomer or homomultimer High-throughput in vitro None Also binds ssDNA loops. IPR009071; 6659 SRY-box 4 [Source:HGNC Symbol;Acc:HGNC:11200] 3U2B DBD Yes None None a Yes TF Gene Candidate_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:7706298 Yes 1a1, Direct HQ evidence Pratyush Das Jussi Taipale Yes $#ENSG00000124766#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:19147588$#ENSG00000124766#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:16631117, PMID:7706298 $#ENSP00000244745#ENSG00000124766#ENST00000244745#HMG# FALSE 1254 ENSG00000134532 SOX5 HMG/Sox Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR009071; 6660 SRY-box 5 [Source:HGNC Symbol;Acc:HGNC:11201] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:1396566;8078769;9755172 Yes 1a1, Direct HQ evidence Sam Lambert Yimeng Yin Yes $#ENSG00000134532#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:8812465 $#ENSP00000379328#ENSG00000134532#ENST00000396007#HMG#CENP-K$#ENSP00000398273#ENSG00000134532#ENST00000451604#HMG#$#ENSP00000437487#ENSG00000134532#ENST00000546136#HMG#$#ENSP00000393240#ENSG00000134532#ENST00000441133#HMG#$#ENSP00000441973#ENSG00000134532#ENST00000541536#HMG#$#ENSP00000443520#ENSG00000134532#ENST00000545921#HMG#$#ENSP00000442119#ENSG00000134532#ENST00000541847#HMG# FALSE 1255 ENSG00000110693 SOX6 HMG/Sox Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR009071; 102464826 SRY-box 6 [Source:HGNC Symbol;Acc:HGNC:16421] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:7567444;11504872 Yes 1a1, Direct HQ evidence Pratyush Das Laura Campitelli Yes $#ENSG00000110693#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:1614875 $#ENSP00000379644#ENSG00000110693#ENST00000396356#HMG#$#ENSP00000434455#ENSG00000110693#ENST00000527619#HMG#$#ENSP00000433233#ENSG00000110693#ENST00000528429#HMG#$#ENSP00000432134#ENSG00000110693#ENST00000528252#HMG#$#ENSP00000434892#ENSG00000110693#ENST00000526673#HMG# FALSE 1256 ENSG00000171056 SOX7 HMG/Sox Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR009071;IPR021934 83595 SRY-box 7 [Source:HGNC Symbol;Acc:HGNC:18196] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:15220343 Yes 1a1, Direct HQ evidence Laura Campitelli Arttu Jolma Yes $#ENSG00000171056#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:19108950$#ENSG00000171056#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019 $#ENSP00000301921#ENSG00000171056#ENST00000304501#HMG#Sox17_18_mid FALSE 1257 ENSG00000005513 SOX8 HMG/Sox Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR009071;IPR022151 30812 SRY-box 8 [Source:HGNC Symbol;Acc:HGNC:11203] None DBD and Full Yes None None a Yes TF Gene Candidate_DNA-Binding: sequence-specific_DNA Binding; TF PPI_PMIDS:12732652 No 1a1, Direct HQ evidence Tim Hughes Sam Lambert Yes $#ENSG00000005513#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IEA - GO_REF:0000019 $#ENSP00000293894#ENSG00000005513#ENST00000293894#HMG#Sox_N FALSE 1258 ENSG00000125398 SOX9 HMG/Sox Yes Known motif Monomer or homomultimer High-throughput in vitro None Also binds ssDNA loops. IPR009071;IPR022151 6662 SRY-box 9 [Source:HGNC Symbol;Acc:HGNC:11204] 4EUW DBD and Full not tested None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:15590666 Yes 1a1, Direct HQ evidence Yimeng Yin Jussi Taipale Yes $#ENSG00000125398#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:20484372, PMID:20530484, PMID:21367821$#ENSG00000125398#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:10805756 | IMP - PMID:8640233$#ENSG00000125398#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#IDA - PMID:20484372, PMID:21412441 $#ENSP00000245479#ENSG00000125398#ENST00000245479#HMG#Sox_N FALSE 1259 ENSG00000184895 SRY HMG/Sox Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR009071;IPR017253 6736 sex determining region Y [Source:HGNC Symbol;Acc:HGNC:11311] 1HRY DBD Yes None None a Yes TF Gene Candidate__DNA Binding_PMIDS:7813448;8190643 Yes 1a1, Direct HQ evidence Arttu Jolma Pratyush Das Yes $#ENSG00000184895#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#IDA - PMID:21412441 $#ENSP00000372547#ENSG00000184895#ENST00000383070#HMG# FALSE 1260 ENSG00000149136 SSRP1 HMG/Sox No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None HMG domain is highly divergent based on AA-sequence IPR000969;IPR009071;IPR013719;IPR024954 6749 structure specific recognition protein 1 [Source:HGNC Symbol;Acc:HGNC:11327] None not tested not tested None None x Yes TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI; Transactivation_PMIDS:10336466 No 4a, two or more datasets predict it as a TF Pratyush Das Jussi Taipale Yes None $#ENSP00000278412#ENSG00000149136#ENST00000278412#HMG#Rtt106, SSrecog$#ENSP00000431154#ENSG00000149136#ENST00000526696#HMG#SSrecog$#ENSP00000434546#ENSG00000149136#ENST00000529002#HMG#SSrecog$#ENSP00000489564#ENSG00000149136#ENST00000635721#HMG# FALSE 1261 ENSG00000081059 TCF7 HMG/Sox Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR009071;IPR013558 6932 transcription factor 7 (T-cell specific, HMG-box) [Source:HGNC Symbol;Acc:HGNC:11639] None DBD Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:7579399 No 1a1, Direct HQ evidence Jussi Taipale Arttu Jolma Yes $#ENSG00000081059#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IEA - GO_REF:0000019 $#ENSP00000340347#ENSG00000081059#ENST00000342854#HMG#CTNNB1_binding$#ENSP00000367822#ENSG00000081059#ENST00000378560#HMG#CTNNB1_binding$#ENSP00000378469#ENSG00000081059#ENST00000395023#HMG#CTNNB1_binding$#ENSP00000430179#ENSG00000081059#ENST00000518915#HMG#CTNNB1_binding$#ENSP00000430617#ENSG00000081059#ENST00000518887#HMG#CTNNB1_binding$#ENSP00000429935#ENSG00000081059#ENST00000520699#HMG#$#ENSP00000429547#ENSG00000081059#ENST00000520958#HMG#CTNNB1_binding FALSE 1262 ENSG00000152284 TCF7L1 HMG/Sox Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR009071;IPR013558 83439 transcription factor 7 like 1 [Source:HGNC Symbol;Acc:HGNC:11640] None DBD and Full not tested None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:2493990;14627819 Yes 1a1, Direct HQ evidence Sam Lambert Laura Campitelli Yes $#ENSG00000152284#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:11085512, PMID:1741298 $#ENSP00000282111#ENSG00000152284#ENST00000282111#HMG#CTNNB1_binding$#ENSP00000388984#ENSG00000152284#ENST00000442813#HMG# FALSE 1263 ENSG00000148737 TCF7L2 HMG/Sox Yes Known motif Monomer or homomultimer 100 perc ID - in vitro None None IPR009071;IPR013558 6934 transcription factor 7 like 2 [Source:HGNC Symbol;Acc:HGNC:11641] None DBD and Full Yes None None a Yes TF Gene Candidate__Other_PMIDS:12861022;15576399;9727977;15060161;15576399 Yes 1a1, Direct HQ evidence Sam Lambert Yimeng Yin Yes $#ENSG00000148737#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:9727977$#ENSG00000148737#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:12799378 $#ENSP00000344823#ENSG00000148737#ENST00000352065#HMG#CTNNB1_binding$#ENSP00000347949#ENSG00000148737#ENST00000355717#HMG#CTNNB1_binding$#ENSP00000348274#ENSG00000148737#ENST00000355995#HMG#CTNNB1_binding$#ENSP00000358404#ENSG00000148737#ENST00000369397#HMG#CTNNB1_binding$#ENSP00000443626#ENSG00000148737#ENST00000534894#HMG#CTNNB1_binding$#ENSP00000446238#ENSG00000148737#ENST00000536810#HMG#CTNNB1_binding$#ENSP00000446172#ENSG00000148737#ENST00000538897#HMG#CTNNB1_binding$#ENSP00000444972#ENSG00000148737#ENST00000543371#HMG#CTNNB1_binding$#ENSP00000440547#ENSG00000148737#ENST00000545257#HMG#CTNNB1_binding$#ENSP00000486891#ENSG00000148737#ENST00000627217#HMG#CTNNB1_binding$#ENSP00000487507#ENSG00000148737#ENST00000629706#HMG#CTNNB1_binding$#ENSP00000490260#ENSG00000148737#ENST00000466338#HMG#$#ENSP00000345640#ENSG00000148737#ENST00000346198#HMG#CTNNB1_binding$#ENSP00000358396#ENSG00000148737#ENST00000369389#HMG#CTNNB1_binding$#ENSP00000490478#ENSG00000148737#ENST00000637574#HMG#CTNNB1_binding FALSE 1264 ENSG00000108064 TFAM HMG/Sox No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None HMG domain is highly divergent based on AA-sequence IPR009071; 7019 transcription factor A, mitochondrial [Source:HGNC Symbol;Acc:HGNC:11741] 3TMM DBD and Full not tested None Structure has long DNA-protein interaction interfaces and the TF works on mitochondrial genome a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:2035027 Yes 1a1, Direct HQ evidence Yimeng Yin Tim Hughes Yes $#ENSG00000108064#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IC - GO_REF:0000036$#ENSG00000108064#GO:0003700#sequence-specific DNA binding transcription factor activity#IMP - PMID:22037171 $#ENSP00000420588#ENSG00000108064#ENST00000487519#HMG#$#ENSP00000363002#ENSG00000108064#ENST00000373895#HMG#$#ENSP00000378776#ENSG00000108064#ENST00000395377#HMG# FALSE 1265 ENSG00000198846 TOX HMG/Sox No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None Predicted to be a non- or low specificity TF (PMID: 12697058). However, there is a DAM-id based motif with SSSSGNNGCG-consensus (PMID: 25527292), but this does not look like HMG-site IPR009071; 9760 thymocyte selection associated high mobility group box [Source:HGNC Symbol;Acc:HGNC:18988] None not tested Yes None None x Yes Indeterminate - There is no evidence for or against this genes role as a TF__Other_PMIDS:11850626;15078895 No 4a, two or more datasets predict it as a TF Arttu Jolma Sam Lambert Yes None $#ENSP00000354842#ENSG00000198846#ENST00000361421#HMG# FALSE 1266 ENSG00000124191 TOX2 HMG/Sox No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None TOX proteins are clearly their own distinct subfamily of HMG proteins. No strong evidence for them binding DNA specifically. IPR009071; 84969 TOX high mobility group box family member 2 [Source:HGNC Symbol;Acc:HGNC:16095] None not tested not tested None None c Yes No No 4a, two or more datasets predict it as a TF Yimeng Yin Pratyush Das Yes None $#ENSP00000362090#ENSG00000124191#ENST00000372999#HMG#$#ENSP00000344724#ENSG00000124191#ENST00000341197#HMG#$#ENSP00000350849#ENSG00000124191#ENST00000358131#HMG#$#ENSP00000390278#ENSG00000124191#ENST00000423191#HMG#$#ENSP00000390876#ENSG00000124191#ENST00000413823#HMG# FALSE 1267 ENSG00000103460 TOX3 HMG/Sox No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None TOX proteins are clearly their own distinct subfamily of HMG proteins. No strong evidence for them binding DNA specifically. IPR009071; 27324 TOX high mobility group box family member 3 [Source:HGNC Symbol;Acc:HGNC:11972] None DBD not tested None Taipale Lab, Unpublished HT-SELEX, direct c Yes No No 1a1, Direct HQ evidence Arttu Jolma Jussi Taipale Yes None $#ENSP00000219746#ENSG00000103460#ENST00000219746#HMG#$#ENSP00000385705#ENSG00000103460#ENST00000407228#HMG#$#ENSP00000457401#ENSG00000103460#ENST00000563091#HMG# FALSE 1268 ENSG00000092203 TOX4 HMG/Sox No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None TOX proteins are clearly their own distinct subfamily of HMG proteins. No strong evidence for them binding DNA specifically. IPR009071; 9878 TOX high mobility group box family member 4 [Source:HGNC Symbol;Acc:HGNC:20161] None DBD not tested None Taipale Lab, Unpublished HT-SELEX, direct c Yes No No 1a1, Direct HQ evidence Jussi Taipale Tim Hughes Yes None $#ENSP00000393080#ENSG00000092203#ENST00000448790#HMG#$#ENSP00000406196#ENSG00000092203#ENST00000457430#HMG#$#ENSP00000402195#ENSG00000092203#ENST00000416256#HMG#$#ENSP00000477868#ENSG00000092203#ENST00000613569#HMG# FALSE 1269 ENSG00000108312 UBTF HMG/Sox No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None No evidence for or against specific DNA-binding by this class of HMG box containing proteins IPR009071;IPR029215 7343 upstream binding transcription factor, RNA polymerase I [Source:HGNC Symbol;Acc:HGNC:12511] None DBD not tested None None a Yes No No 4a, two or more datasets predict it as a TF Matt Weirauch Yimeng Yin Yes None $#ENSP00000345297#ENSG00000108312#ENST00000343638#HMG#$#ENSP00000377231#ENSG00000108312#ENST00000393606#HMG#$#ENSP00000435708#ENSG00000108312#ENST00000529383#HMG#$#ENSP00000302640#ENSG00000108312#ENST00000302904#HMG#$#ENSP00000390669#ENSG00000108312#ENST00000436088#HMG#$#ENSP00000431295#ENSG00000108312#ENST00000529373#HMG# FALSE 1270 ENSG00000255009 UBTFL1 HMG/Sox No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None No evidence for or against specific DNA-binding by this class of HMG box containing proteins IPR009071 642623 upstream binding transcription factor, RNA polymerase I-like 1 [Source:HGNC Symbol;Acc:HGNC:14533] None not tested not tested None None No Yes No No 5a, one of the source datasets predicts is as a TF Sam Lambert Pratyush Das Yes None $#ENSP00000485108#ENSG00000255009#ENST00000530464#HMG# FALSE 1271 ENSG00000198554 WDHD1 HMG/Sox No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None Divergent HMG motif, doesnt cluster either with specific or nonspecific HMG proteins IPR001680;IPR009071;IPR013979;IPR017986;IPR019775;IPR022100 11169 WD repeat and HMG-box DNA binding protein 1 [Source:HGNC Symbol;Acc:HGNC:23170] None DBD not tested None None c Yes No No 4a, two or more datasets predict it as a TF Pratyush Das Jussi Taipale No None $#ENSP00000353793#ENSG00000198554#ENST00000360586#HMG#ANAPC4_WD40, Ge1_WD40, Mcl1_mid, WD40, eIF2A$#ENSP00000413435#ENSG00000198554#ENST00000455555#HMG#ANAPC4_WD40, Ge1_WD40, WD40$#ENSP00000399349#ENSG00000198554#ENST00000420358#HMG#ANAPC4_WD40, Mcl1_mid, WD40, eIF2A FALSE 1272 ENSG00000237452 BHMG1 HMG/Sox; bHLH No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Based on the alignment, it lacks a proper HMG domain. bHLH domain is also highly unlike any other human bHLH TF (<40% DBD ID) IPR009071;IPR011598 388553 basic helix-loop-helix and HMG-box containing 1 [Source:HGNC Symbol;Acc:HGNC:44318] None not tested not tested None None No Yes No No 5a, one of the source datasets predicts is as a TF Jussi Taipale Laura Campitelli No None $#ENSP00000402674#ENSG00000237452#ENST00000457052#HMG#APC_basic FALSE 1273 ENSG00000101126 ADNP Homeodomain Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR001356;IPR007087;IPR009057;IPR015880 23394 activity dependent neuroprotector homeobox [Source:HGNC Symbol;Acc:HGNC:15766] None DBD and Full Yes None PMID: 25169753 Associated with autism and interacts with SWI/SNF nucleosome remodeling complex b Yes No No 3a, decent circumstantial evidence for its role as Yimeng Yin Matt Weirauch Yes None $#ENSP00000342905#ENSG00000101126#ENST00000349014#Homeodomain#zf-C2H2_4$#ENSP00000360662#ENSG00000101126#ENST00000371602#Homeodomain#zf-C2H2_4$#ENSP00000379346#ENSG00000101126#ENST00000396029#Homeodomain#zf-C2H2_4$#ENSP00000379349#ENSG00000101126#ENST00000396032#Homeodomain#zf-C2H2_4$#ENSP00000436181#ENSG00000101126#ENST00000534467#Homeodomain#zf-Di19 FALSE 1274 ENSG00000101544 ADNP2 Homeodomain Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR001356;IPR007087;IPR009057;IPR015880 22850 ADNP homeobox 2 [Source:HGNC Symbol;Acc:HGNC:23803] None DBD and Full not tested None PMID:25169753;Homologous to ADNP that PMID: 25169753 Associated with autism and interacts with SWI/SNF nucleosome remodeling complex b Yes No No 3a, decent circumstantial evidence for its role as Yimeng Yin Matt Weirauch Yes None $#ENSP00000262198#ENSG00000101544#ENST00000262198#Homeodomain#DUF4674, zf-C2H2_4$#ENSP00000453275#ENSG00000101544#ENST00000559951#Homeodomain#$#ENSP00000468397#ENSG00000101544#ENST00000560561#Homeodomain#$#ENSP00000467370#ENSG00000101544#ENST00000561195#Homeodomain# FALSE 1275 ENSG00000180318 ALX1 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR003654;IPR009057;IPR017970 8092 ALX homeobox 1 [Source:HGNC Symbol;Acc:HGNC:1494] None DBD and Full not tested None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:9753625;12390248;8756334;9847249;12390248 Yes 1a1, Direct HQ evidence Jussi Taipale Pratyush Das Yes $#ENSG00000180318#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IDA - PMID:9753625$#ENSG00000180318#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:8756334 $#ENSP00000315417#ENSG00000180318#ENST00000316824#Homeodomain#OAR FALSE 1276 ENSG00000156150 ALX3 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR009057;IPR017970; 257 ALX homeobox 3 [Source:HGNC Symbol;Acc:HGNC:449] None DBD and Full Yes None None a Yes No No 1a1, Direct HQ evidence Sam Lambert Yimeng Yin Yes None $#ENSP00000358807#ENSG00000156150#ENST00000369792#Homeodomain# FALSE 1277 ENSG00000052850 ALX4 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR003654;IPR009057;IPR017970 60529 ALX homeobox 4 [Source:HGNC Symbol;Acc:HGNC:450] None DBD Yes None None a Yes No No 1a1, Direct HQ evidence Arttu Jolma Laura Campitelli Yes $#ENSG00000052850#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IEA - GO_REF:0000019 $#ENSP00000332744#ENSG00000052850#ENST00000329255#Homeodomain#OAR FALSE 1278 ENSG00000227059 ANHX Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR009057;IPR017970; 647589 anomalous homeobox [Source:HGNC Symbol;Acc:HGNC:40024] None not tested Yes None TFs that are in CisBP but not in Vaquerizas set No Yes No No 1a1, Direct HQ evidence Laura Campitelli Jussi Taipale No None $#ENSP00000409950#ENSG00000227059#ENST00000419717#Homeodomain#SIX1_SD$#ENSP00000439513#ENSG00000227059#ENST00000545940#Homeodomain#SIX1_SD FALSE 1279 ENSG00000186103 ARGFX Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR009057;IPR017970; 503582 arginine-fifty homeobox [Source:HGNC Symbol;Acc:HGNC:30146] None DBD not tested None None b Yes No No 1a1, Direct HQ evidence Sam Lambert Yimeng Yin Yes None $#ENSP00000335578#ENSG00000186103#ENST00000334384#Homeodomain# FALSE 1280 ENSG00000004848 ARX Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR003654;IPR009057;IPR017970 170302 aristaless related homeobox [Source:HGNC Symbol;Acc:HGNC:18060] None DBD Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:15930104 Yes 1a1, Direct HQ evidence Pratyush Das Matt Weirauch Yes $#ENSG00000004848#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IDA - PMID:16301625$#ENSG00000004848#GO:0001206#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involv#IEA - GO_REF:0000019 $#ENSP00000368332#ENSG00000004848#ENST00000379044#Homeodomain#OAR$#ENSP00000490122#ENSG00000004848#ENST00000637993#Homeodomain# FALSE 1281 ENSG00000125492 BARHL1 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR009057;IPR017970;IPR020479 56751 BarH like homeobox 1 [Source:HGNC Symbol;Acc:HGNC:953] None DBD and Full Yes None None a Yes TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_Transactivation_PMIDS:16226339 Yes 1a1, Direct HQ evidence Yimeng Yin Arttu Jolma Yes $#ENSG00000125492#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000125492#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IBA - GO_REF:0000033 $#ENSP00000263610#ENSG00000125492#ENST00000263610#Homeodomain#$#ENSP00000444704#ENSG00000125492#ENST00000542090#Homeodomain# FALSE 1282 ENSG00000143032 BARHL2 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR009057;IPR017970;IPR020479 343472 BarH like homeobox 2 [Source:HGNC Symbol;Acc:HGNC:954] None DBD and Full Yes None None a Yes No Yes 1a1, Direct HQ evidence Jussi Taipale Arttu Jolma Yes $#ENSG00000143032#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000143032#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IBA - GO_REF:0000033 $#ENSP00000359474#ENSG00000143032#ENST00000370445#Homeodomain# FALSE 1283 ENSG00000131668 BARX1 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro Has a putative AT-hook None IPR000047;IPR001356;IPR009057;IPR017970;IPR020479; 56033 BARX homeobox 1 [Source:HGNC Symbol;Acc:HGNC:955] None DBD and Full Yes None None a Yes TF Gene Candidate__Transactivation_PMIDS:15809042;7669690;15809042 Yes 1a1, Direct HQ evidence Pratyush Das Sam Lambert Yes $#ENSG00000131668#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IBA - GO_REF:0000033$#ENSG00000131668#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:10995576 $#ENSP00000253968#ENSG00000131668#ENST00000253968#Homeodomain#$#ENSP00000385613#ENSG00000131668#ENST00000401724#Homeodomain# FALSE 1284 ENSG00000043039 BARX2 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro Has a putative AT-hook None IPR000047;IPR001356;IPR009057;IPR017970;IPR020479; 8538 BARX homeobox 2 [Source:HGNC Symbol;Acc:HGNC:956] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:14744868;15728386 Yes 1a1, Direct HQ evidence Matt Weirauch Arttu Jolma Yes $#ENSG00000043039#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IMP - PMID:14744868 $#ENSP00000281437#ENSG00000043039#ENST00000281437#Homeodomain# FALSE 1285 ENSG00000188909 BSX Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR009057;IPR017970;IPR020479 390259 brain specific homeobox [Source:HGNC Symbol;Acc:HGNC:20450] None DBD Yes None None c Yes No Yes 1a1, Direct HQ evidence Sam Lambert Arttu Jolma Yes $#ENSG00000188909#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019 $#ENSP00000344285#ENSG00000188909#ENST00000343035#Homeodomain# FALSE 1286 ENSG00000113722 CDX1 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000047;IPR001356;IPR006820;IPR009057;IPR017970;IPR020479 1044 caudal type homeobox 1 [Source:HGNC Symbol;Acc:HGNC:1805] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:15677472;15774940;7585967;12954759 Yes 1a1, Direct HQ evidence Arttu Jolma Sam Lambert Yes $#ENSG00000113722#GO:0001205#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involv#IDA - PMID:15774940 $#ENSP00000231656#ENSG00000113722#ENST00000231656#Homeodomain#Caudal_act$#ENSP00000477928#ENSG00000113722#ENST00000616154#Homeodomain#Caudal_act FALSE 1287 ENSG00000165556 CDX2 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000047;IPR001356;IPR006820;IPR009057;IPR017970;IPR020479 1045 caudal type homeobox 2 [Source:HGNC Symbol;Acc:HGNC:1806] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:7935448 Yes 1a1, Direct HQ evidence Pratyush Das Jussi Taipale Yes $#ENSG00000165556#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IDA - PMID:15677472$#ENSG00000165556#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:9459001 $#ENSP00000370408#ENSG00000165556#ENST00000381020#Homeodomain#Caudal_act FALSE 1288 ENSG00000131264 CDX4 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000047;IPR001356;IPR006820;IPR009057;IPR017970;IPR020479 1046 caudal type homeobox 4 [Source:HGNC Symbol;Acc:HGNC:1808] None Full not tested None None a Yes No Yes 1a1, Direct HQ evidence Arttu Jolma Laura Campitelli Yes $#ENSG00000131264#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:21471217 | IMP - PMID:21471217 $#ENSP00000362613#ENSG00000131264#ENST00000373514#Homeodomain#Caudal_act FALSE 1289 ENSG00000143418 CERS2 Homeodomain No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Unlikely to be a TF - homeodomain is heavily truncated at the N-terminus; and LASS2/CERS2 has previously been shown to be involved in ceramide synthesis (PMID:20937905). IPR001356;IPR006634;IPR009057;IPR016439 29956 ceramide synthase 2 [Source:HGNC Symbol;Acc:HGNC:14076] None not tested not tested None None x Yes No No 4a, two or more datasets predict it as a TF Yimeng Yin Sam Lambert No None $#ENSP00000357950#ENSG00000143418#ENST00000368954#Homeodomain#TRAM_LAG1_CLN8$#ENSP00000453297#ENSG00000143418#ENST00000560793#Homeodomain#TRAM_LAG1_CLN8$#ENSP00000355020#ENSG00000143418#ENST00000361419#Homeodomain#TRAM_LAG1_CLN8$#ENSP00000452810#ENSG00000143418#ENST00000558062#Homeodomain#TRAM_LAG1_CLN8$#ENSP00000393239#ENSG00000143418#ENST00000421609#Homeodomain#TRAM_LAG1_CLN8$#ENSP00000394012#ENSG00000143418#ENST00000457392#Homeodomain# FALSE 1290 ENSG00000154227 CERS3 Homeodomain No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Unlikely to be a TF - homeodomain is heavily truncated at the N-terminus; and LASS2/CERS2 has previously been shown to be involved in ceramide synthesis (PMID:20937905). IPR001356;IPR006634;IPR009057;IPR016439 204219 ceramide synthase 3 [Source:HGNC Symbol;Acc:HGNC:23752] None DBD and Full Yes None None b Yes No No 4a, two or more datasets predict it as a TF Jussi Taipale Pratyush Das No None $#ENSP00000284382#ENSG00000154227#ENST00000284382#Homeodomain#TRAM_LAG1_CLN8$#ENSP00000377672#ENSG00000154227#ENST00000394113#Homeodomain#TRAM_LAG1_CLN8$#ENSP00000437640#ENSG00000154227#ENST00000538112#Homeodomain#TRAM_LAG1_CLN8$#ENSP00000453598#ENSG00000154227#ENST00000559639#Homeodomain# FALSE 1291 ENSG00000090661 CERS4 Homeodomain No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Unlikely to be a TF - homeodomain is heavily truncated at the N-terminus; and LASS2/CERS2 has previously been shown to be involved in ceramide synthesis (PMID:20937905). IPR001356;IPR006634;IPR009057;IPR016439 79603 ceramide synthase 4 [Source:HGNC Symbol;Acc:HGNC:23747] None not tested not tested None None x Yes No No 4a, two or more datasets predict it as a TF Matt Weirauch Pratyush Das No None $#ENSP00000251363#ENSG00000090661#ENST00000251363#Homeodomain#TRAM_LAG1_CLN8$#ENSP00000453815#ENSG00000090661#ENST00000559336#Homeodomain#TRAM_LAG1_CLN8$#ENSP00000453388#ENSG00000090661#ENST00000558268#Homeodomain#$#ENSP00000454122#ENSG00000090661#ENST00000558877#Homeodomain#TRAM_LAG1_CLN8 FALSE 1292 ENSG00000139624 CERS5 Homeodomain No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Unlikely to be a TF - homeodomain is heavily truncated at the N-terminus; and LASS2/CERS2 has previously been shown to be involved in ceramide synthesis (PMID:20937905). IPR001356;IPR006634;IPR009057;IPR016439 91012 ceramide synthase 5 [Source:HGNC Symbol;Acc:HGNC:23749] None Full not tested None None x Yes No No 4a, two or more datasets predict it as a TF Arttu Jolma Jussi Taipale No None $#ENSP00000325485#ENSG00000139624#ENST00000317551#Homeodomain#TRAM_LAG1_CLN8$#ENSP00000389050#ENSG00000139624#ENST00000422340#Homeodomain#TRAM_LAG1_CLN8$#ENSP00000448295#ENSG00000139624#ENST00000547800#Homeodomain#TRAM_LAG1_CLN8$#ENSP00000449311#ENSG00000139624#ENST00000550919#Homeodomain#TRAM_LAG1_CLN8$#ENSP00000447266#ENSG00000139624#ENST00000553122#Homeodomain#TRAM_LAG1_CLN8 FALSE 1293 ENSG00000172292 CERS6 Homeodomain No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Unlikely to be a TF - homeodomain is heavily truncated at the N-terminus; and LASS2/CERS2 has previously been shown to be involved in ceramide synthesis (PMID:20937905). IPR001356;IPR006634;IPR009057;IPR016439 253782 ceramide synthase 6 [Source:HGNC Symbol;Acc:HGNC:23826] None DBD and Full not tested None None c Yes No No 4a, two or more datasets predict it as a TF Yimeng Yin Jussi Taipale No None $#ENSP00000376453#ENSG00000172292#ENST00000392687#Homeodomain#TRAM_LAG1_CLN8$#ENSP00000306579#ENSG00000172292#ENST00000305747#Homeodomain#TRAM_LAG1_CLN8 FALSE 1294 ENSG00000105392 CRX Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR009057;IPR013851;IPR017970 1406 cone-rod homeobox [Source:HGNC Symbol;Acc:HGNC:2383] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:15001570;16332268 Yes 1a1, Direct HQ evidence Sam Lambert Laura Campitelli Yes $#ENSG00000105392#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:10625658$#ENSG00000105392#GO:0003700#sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024 $#ENSP00000221996#ENSG00000105392#ENST00000221996#Homeodomain#TF_Otx$#ENSP00000478106#ENSG00000105392#ENST00000613299#Homeodomain#$#ENSP00000445565#ENSG00000105392#ENST00000539067#Homeodomain#TF_Otx$#ENSP00000457808#ENSG00000105392#ENST00000566686#Homeodomain# FALSE 1295 ENSG00000109851 DBX1 Homeodomain Yes Inferred motif Monomer or homomultimer High-throughput in vitro None None IPR000047;IPR001356;IPR009057;IPR017970;IPR020479; 120237 developing brain homeobox 1 [Source:HGNC Symbol;Acc:HGNC:33185] None DBD Yes None None b Yes Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0 No 1a1, Direct HQ evidence Arttu Jolma Jussi Taipale Yes None $#ENSP00000436881#ENSG00000109851#ENST00000524983#Homeodomain# FALSE 1296 ENSG00000185610 DBX2 Homeodomain Yes Inferred motif Monomer or homomultimer High-throughput in vitro None None IPR000047;IPR001356;IPR009057;IPR017970;IPR020479; 440097 developing brain homeobox 2 [Source:HGNC Symbol;Acc:HGNC:33186] None DBD Yes None None b Yes No No 1a1, Direct HQ evidence Arttu Jolma Pratyush Das Yes None $#ENSP00000331470#ENSG00000185610#ENST00000332700#Homeodomain# FALSE 1297 ENSG00000144355 DLX1 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000047;IPR001356;IPR009057;IPR017970;IPR020479; 1745 distal-less homeobox 1 [Source:HGNC Symbol;Acc:HGNC:2914] None DBD and Full Yes None None a Yes No No 1a1, Direct HQ evidence Matt Weirauch Sam Lambert Yes None $#ENSP00000341786#ENSG00000144355#ENST00000341900#Homeodomain#$#ENSP00000354478#ENSG00000144355#ENST00000361725#Homeodomain#$#ENSP00000448827#ENSG00000144355#ENST00000469444#Homeodomain#$#ENSP00000354865#ENSG00000144355#ENST00000361609#Homeodomain# FALSE 1298 ENSG00000115844 DLX2 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000047;IPR001356;IPR009057;IPR017970;IPR020479;IPR022135 1746 distal-less homeobox 2 [Source:HGNC Symbol;Acc:HGNC:2915] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:9415433;14769946 Yes 1a1, Direct HQ evidence Arttu Jolma Laura Campitelli Yes $#ENSG00000115844#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IEA - GO_REF:0000019$#ENSG00000115844#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:1354641 $#ENSP00000234198#ENSG00000115844#ENST00000234198#Homeodomain#DLL_N$#ENSP00000446904#ENSG00000115844#ENST00000466293#Homeodomain#DLL_N FALSE 1299 ENSG00000064195 DLX3 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000047;IPR001356;IPR009057;IPR017970;IPR020479;IPR022135 1747 distal-less homeobox 3 [Source:HGNC Symbol;Acc:HGNC:2916] 4XRS DBD and Full Yes None Heterodimer with MEIS1-DLX3 a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; TF PPI_PMIDS:16687405 Yes 1a1, Direct HQ evidence Matt Weirauch Arttu Jolma Yes $#ENSG00000064195#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000064195#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:9467018 $#ENSP00000389870#ENSG00000064195#ENST00000434704#Homeodomain#DLL_N$#ENSP00000449976#ENSG00000064195#ENST00000512495#Homeodomain# FALSE 1300 ENSG00000108813 DLX4 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000047;IPR001356;IPR009057;IPR017970;IPR020479; 1748 distal-less homeobox 4 [Source:HGNC Symbol;Acc:HGNC:2917] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:11909945 Yes 1a1, Direct HQ evidence Yimeng Yin Sam Lambert Yes $#ENSG00000108813#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:11909945$#ENSG00000108813#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:11069021 $#ENSP00000240306#ENSG00000108813#ENST00000240306#Homeodomain#$#ENSP00000410622#ENSG00000108813#ENST00000411890#Homeodomain#$#ENSP00000480366#ENSG00000108813#ENST00000611342#Homeodomain# FALSE 1301 ENSG00000105880 DLX5 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000047;IPR001356;IPR009057;IPR017970;IPR020479;IPR022135 1749 distal-less homeobox 5 [Source:HGNC Symbol;Acc:HGNC:2918] 4RDU DBD and Full Yes None Monomer, makes a protein protein interaction on packing a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:15383550 Yes 1a1, Direct HQ evidence Jussi Taipale Tim Hughes Yes $#ENSG00000105880#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#ISS - GO_REF:0000024 $#ENSP00000222598#ENSG00000105880#ENST00000222598#Homeodomain#DLL_N$#ENSP00000475008#ENSG00000105880#ENST00000486603#Homeodomain#DLL_N FALSE 1302 ENSG00000006377 DLX6 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000047;IPR001356;IPR009057;IPR017970;IPR020479; 1750 Distal-less homeobox 6 [Source:HGNC Symbol;Acc:HGNC:2919] None DBD and Full not tested None None a Yes No No 1a1, Direct HQ evidence Sam Lambert Jussi Taipale Yes $#ENSG00000006377#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:7907794 $#ENSP00000428480#ENSG00000006377#ENST00000518156#Homeodomain#RskA$#ENSP00000451635#ENSG00000006377#ENST00000555308#Homeodomain# FALSE 1303 ENSG00000197587 DMBX1 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR003654;IPR009057;IPR017970 127343 diencephalon/mesencephalon homeobox 1 [Source:HGNC Symbol;Acc:HGNC:19026] None DBD Yes None None b Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:12055180 Yes 1a1, Direct HQ evidence Yimeng Yin Jussi Taipale Yes $#ENSG00000197587#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IEA - GO_REF:0000019$#ENSG00000197587#GO:0003700#sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024 $#ENSP00000353132#ENSG00000197587#ENST00000360032#Homeodomain#OAR$#ENSP00000361024#ENSG00000197587#ENST00000371956#Homeodomain#OAR FALSE 1304 ENSG00000204595 DPRX Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR009057;IPR017970; 503834 divergent-paired related homeobox [Source:HGNC Symbol;Acc:HGNC:32166] None DBD not tested None None b Yes No No 1a1, Direct HQ evidence Laura Campitelli Jussi Taipale Yes None $#ENSP00000365838#ENSG00000204595#ENST00000376650#Homeodomain# FALSE 1305 ENSG00000165606 DRGX Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR003654;IPR009057;IPR017970 644168 dorsal root ganglia homeobox [Source:HGNC Symbol;Acc:HGNC:21536] None DBD not tested None None b Yes TF Gene_DNA-Binding: sequence-specific_Other_PMIDS:12917357;14985445 No 1a1, Direct HQ evidence Pratyush Das Laura Campitelli Yes None $#ENSP00000363254#ENSG00000165606#ENST00000374139#Homeodomain#OAR$#ENSP00000401653#ENSG00000165606#ENST00000434016#Homeodomain#OAR FALSE 1306 DUX1_HUMAN DUX1 Homeodomain Yes Known motif Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain Not included in Ensembl. Binds GATCTGAGTCTAATTGAGAATTACTGTAC in EMSA (PMID: 9736770) None None double homeobox 1 None not tested not tested None Not included in Ensembl. Binds GATCTGAGTCTAATTGAGAATTACTGTAC in EMSA (PMID: 9736770) No Yes No No Protein added after initial stage, no initial assesment Arttu Jolma Sam Lambert Yes None None FALSE 1307 DUX3_HUMAN DUX3 Homeodomain Yes Known motif Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain Not included in Ensembl. None None double homeobox 3 None not tested not tested None Not included in Ensembl. No Yes No No Protein added after initial stage, no initial assesment Arttu Jolma Sam Lambert Yes None None FALSE 1308 ENSG00000260596 DUX4 Homeodomain Yes Known motif Monomer or homomultimer In vivo/Misc source None None IPR000047;IPR001356;IPR009057; 107987491 double homeobox 4 [Source:HGNC Symbol;Acc:HGNC:50800] None not tested Yes None ChIP-seq model in the Jaspar is similar to paralogous DUXA HT-SELEX model No Yes No No 1a1, Direct HQ evidence Arttu Jolma Pratyush Das Yes None $#ENSP00000458065#ENSG00000260596#ENST00000565211#Homeodomain#$#ENSP00000455112#ENSG00000260596#ENST00000570263#Homeodomain#$#ENSP00000456539#ENSG00000260596#ENST00000569241#Homeodomain#$#ENSP00000483555#ENSG00000260596#ENST00000616166#Homeodomain# FALSE 1309 ENSG00000258873 DUXA Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000047;IPR001356;IPR009057; 503835 double homeobox A [Source:HGNC Symbol;Acc:HGNC:32179] None DBD Yes None None b Yes No No 1a1, Direct HQ evidence Pratyush Das Arttu Jolma Yes None $#ENSP00000452398#ENSG00000258873#ENST00000554048#Homeodomain# FALSE 1310 ENSG00000135638 EMX1 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR009057;IPR017970;IPR020479 2016 empty spiracles homeobox 1 [Source:HGNC Symbol;Acc:HGNC:3340] None DBD and Full Yes None None b Yes TF Gene Candidate_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:1352754 No 1a1, Direct HQ evidence Tim Hughes Arttu Jolma Yes None $#ENSP00000258106#ENSG00000135638#ENST00000258106#Homeodomain#$#ENSP00000482619#ENSG00000135638#ENST00000394111#Homeodomain#$#ENSP00000446992#ENSG00000135638#ENST00000473732#Homeodomain# FALSE 1311 ENSG00000170370 EMX2 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000047;IPR001356;IPR009057;IPR017970;IPR020479; 2018 empty spiracles homeobox 2 [Source:HGNC Symbol;Acc:HGNC:3341] None DBD Yes None None a Yes TF Gene Candidate_DNA-Binding: sequence-specific_DNA Binding_PMIDS:1352754;16919471 No 1a1, Direct HQ evidence Laura Campitelli Arttu Jolma Yes None $#ENSP00000450962#ENSG00000170370#ENST00000553456#Homeodomain#$#ENSP00000474874#ENSG00000170370#ENST00000442245#Homeodomain#$#ENSP00000480271#ENSG00000170370#ENST00000616794#Homeodomain# FALSE 1312 ENSG00000163064 EN1 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000747;IPR001356;IPR009057;IPR017970;IPR019549;IPR019737;IPR020479; 2019 engrailed homeobox 1 [Source:HGNC Symbol;Acc:HGNC:3342] None DBD and Full Yes None None b Yes TF Gene_DNA-Binding: sequence-specific; Transcription Factor Binding: tf co-factor binding_DNA Binding_PMIDS:8096059;10504454 Yes 1a1, Direct HQ evidence Sam Lambert Arttu Jolma Yes $#ENSG00000163064#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:21672318 $#ENSP00000295206#ENSG00000163064#ENST00000295206#Homeodomain#Engrail_1_C_sig FALSE 1313 ENSG00000164778 EN2 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000747;IPR001356;IPR009057;IPR017970;IPR019549;IPR019737;IPR020479; 2020 engrailed homeobox 2 [Source:HGNC Symbol;Acc:HGNC:3343] None DBD and Full Yes None None b Yes TF Gene_Transcription Factor Binding: tf co-factor binding; DNA-Binding: sequence-specific_Co-activation_PMIDS:9813123 No 1a1, Direct HQ evidence Matt Weirauch Arttu Jolma Yes None $#ENSP00000297375#ENSG00000164778#ENST00000297375#Homeodomain#Engrail_1_C_sig FALSE 1314 ENSG00000123576 ESX1 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR009057;IPR013847;IPR017970 80712 ESX homeobox 1 [Source:HGNC Symbol;Acc:HGNC:14865] None DBD and Full Yes None None b Yes TF Gene Candidate_DNA-Binding: sequence-specific_DNA Binding_PMIDS:10611245 Yes 1a1, Direct HQ evidence Jussi Taipale Pratyush Das Yes $#ENSG00000123576#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IDA - PMID:15897875 | IMP - PMID:15897875 $#ENSP00000361669#ENSG00000123576#ENST00000372588#Homeodomain# FALSE 1315 ENSG00000106038 EVX1 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR009057;IPR017970;IPR020479 2128 even-skipped homeobox 1 [Source:HGNC Symbol;Acc:HGNC:3506] None DBD Yes None None b Yes No Yes 1a1, Direct HQ evidence Laura Campitelli Yimeng Yin Yes $#ENSG00000106038#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:1684419 $#ENSP00000222761#ENSG00000106038#ENST00000222761#Homeodomain#$#ENSP00000419266#ENSG00000106038#ENST00000496902#Homeodomain#$#ENSP00000463759#ENSG00000106038#ENST00000580535#Homeodomain# FALSE 1316 ENSG00000174279 EVX2 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR009057;IPR017970;IPR020479 344191 even-skipped homeobox 2 [Source:HGNC Symbol;Acc:HGNC:3507] None DBD Yes None None b Yes Indeterminate - There is no evidence for or against this genes role as a TF__Transactivation_PMIDS:8978698 No 1a1, Direct HQ evidence Arttu Jolma Yimeng Yin Yes None $#ENSP00000312385#ENSG00000174279#ENST00000308618#Homeodomain# FALSE 1317 ENSG00000164900 GBX1 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR009057;IPR017970;IPR020479 2636 gastrulation brain homeobox 1 [Source:HGNC Symbol;Acc:HGNC:4185] 2ME6 DBD Yes None NMR structure of monomer b Yes Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0 No 1a1, Direct HQ evidence Yimeng Yin Jussi Taipale Yes None $#ENSP00000297537#ENSG00000164900#ENST00000297537#Homeodomain# FALSE 1318 ENSG00000168505 GBX2 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR009057;IPR017970;IPR020479 2637 gastrulation brain homeobox 2 [Source:HGNC Symbol;Acc:HGNC:4186] None DBD and Full Yes None None b Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:10690529 Yes 1a1, Direct HQ evidence Yimeng Yin Laura Campitelli Yes $#ENSG00000168505#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:9346236 $#ENSP00000302251#ENSG00000168505#ENST00000306318#Homeodomain#$#ENSP00000448747#ENSG00000168505#ENST00000551105#Homeodomain# FALSE 1319 ENSG00000133937 GSC Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR009057;IPR017970; 145258 goosecoid homeobox [Source:HGNC Symbol;Acc:HGNC:4612] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:9417125;10542273 No 1a1, Direct HQ evidence Matt Weirauch Tim Hughes Yes None $#ENSP00000238558#ENSG00000133937#ENST00000238558#Homeodomain# FALSE 1320 ENSG00000063515 GSC2 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR009057;IPR017970; 2928 goosecoid homeobox 2 [Source:HGNC Symbol;Acc:HGNC:4613] None DBD not tested None None a Yes No Yes 1a1, Direct HQ evidence Laura Campitelli Tim Hughes Yes $#ENSG00000063515#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:9700206 $#ENSP00000086933#ENSG00000063515#ENST00000086933#Homeodomain# FALSE 1321 ENSG00000169840 GSX1 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR009057;IPR017970;IPR020479 219409 GS homeobox 1 [Source:HGNC Symbol;Acc:HGNC:20374] None DBD not tested None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:11731616 No 1a1, Direct HQ evidence Sam Lambert Arttu Jolma Yes $#ENSG00000169840#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019 $#ENSP00000304331#ENSG00000169840#ENST00000302945#Homeodomain# FALSE 1322 ENSG00000180613 GSX2 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR009057;IPR017970;IPR020479 170825 GS homeobox 2 [Source:HGNC Symbol;Acc:HGNC:24959] None DBD not tested None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:7619729 No 1a1, Direct HQ evidence Sam Lambert Pratyush Das Yes None $#ENSP00000319118#ENSG00000180613#ENST00000326902#Homeodomain#$#ENSP00000483522#ENSG00000180613#ENST00000611459#Homeodomain#$#ENSP00000422213#ENSG00000180613#ENST00000503800#Homeodomain# FALSE 1323 ENSG00000165259 HDX Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR009057 139324 highly divergent homeobox [Source:HGNC Symbol;Acc:HGNC:26411] None DBD and Full Yes None None b Yes No No 1a1, Direct HQ evidence Matt Weirauch Yimeng Yin Yes None $#ENSP00000297977#ENSG00000165259#ENST00000297977#Homeodomain#$#ENSP00000362272#ENSG00000165259#ENST00000373177#Homeodomain#$#ENSP00000423670#ENSG00000165259#ENST00000506585#Homeodomain#$#ENSP00000387790#ENSG00000165259#ENST00000449553#Homeodomain# FALSE 1324 ENSG00000163666 HESX1 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR009057;IPR017970; 8820 HESX homeobox 1 [Source:HGNC Symbol;Acc:HGNC:4877] None DBD and Full not tested None None a Yes TF Gene Candidate_DNA-Binding: sequence-specific_DNA Binding_PMIDS:9620767;11748154;12063185 No 1a1, Direct HQ evidence Matt Weirauch Arttu Jolma Yes None $#ENSP00000295934#ENSG00000163666#ENST00000295934#Homeodomain#$#ENSP00000419615#ENSG00000163666#ENST00000495160#Homeodomain#$#ENSP00000418918#ENSG00000163666#ENST00000473921#Homeodomain# FALSE 1325 ENSG00000152804 HHEX Homeodomain Yes Inferred motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR009057;IPR017970;IPR020479 3087 hematopoietically expressed homeobox [Source:HGNC Symbol;Acc:HGNC:4901] None DBD and Full Yes None None a Yes TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:16146628 Yes 1a2, Orthologous HQ evidence Yimeng Yin Sam Lambert Yes $#ENSG00000152804#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:15016828 $#ENSP00000282728#ENSG00000152804#ENST00000282728#Homeodomain#$#ENSP00000447953#ENSG00000152804#ENST00000492654#Homeodomain#$#ENSP00000450017#ENSG00000152804#ENST00000472590#Homeodomain# FALSE 1326 ENSG00000136630 HLX Homeodomain Yes Known motif Monomer or homomultimer 100 perc ID - in vitro None None IPR000047;IPR001356;IPR009057;IPR017970;IPR020479; 3142 H2.0 like homeobox [Source:HGNC Symbol;Acc:HGNC:4978] None DBD and Full not tested None None a Yes No No 1a1, Direct HQ evidence Tim Hughes Laura Campitelli Yes None $#ENSP00000355870#ENSG00000136630#ENST00000366903#Homeodomain#$#ENSP00000408248#ENSG00000136630#ENST00000427693#Homeodomain# FALSE 1327 ENSG00000147421 HMBOX1 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR006899;IPR009057;IPR010982 79618 homeobox containing 1 [Source:HGNC Symbol;Acc:HGNC:26137] 4J19 DBD and Full Yes None Structure is a homodimer b Yes No No 1a1, Direct HQ evidence Matt Weirauch Laura Campitelli Yes None $#ENSP00000287701#ENSG00000147421#ENST00000287701#Homeodomain#HNF-1_N, HTH_19, HTH_3, HTH_37$#ENSP00000380516#ENSG00000147421#ENST00000397358#Homeodomain#HNF-1_N, HTH_19, HTH_3, HTH_37$#ENSP00000452827#ENSG00000147421#ENST00000523613#Homeodomain#HNF-1_N, HTH_19, HTH_3, HTH_37$#ENSP00000430110#ENSG00000147421#ENST00000524238#Homeodomain#HNF-1_N, HTH_19, HTH_3, HTH_37 FALSE 1328 ENSG00000215612 HMX1 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR009057;IPR017970;IPR020479 3166 H6 family homeobox 1 [Source:HGNC Symbol;Acc:HGNC:5017] None DBD Yes None None a Yes No No 1a1, Direct HQ evidence Arttu Jolma Pratyush Das Yes $#ENSG00000215612#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IEA - GO_REF:0000019 $#ENSP00000383516#ENSG00000215612#ENST00000400677#Homeodomain#$#ENSP00000446997#ENSG00000215612#ENST00000506970#Homeodomain# FALSE 1329 ENSG00000188816 HMX2 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR009057;IPR017970;IPR020479 3167 H6 family homeobox 2 [Source:HGNC Symbol;Acc:HGNC:5018] None DBD and Full Yes None None c Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:10543441;15363417 No 1a1, Direct HQ evidence Arttu Jolma Pratyush Das Yes None $#ENSP00000341108#ENSG00000188816#ENST00000339992#Homeodomain# FALSE 1330 ENSG00000188620 HMX3 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR009057;IPR017970;IPR020479 340784 H6 family homeobox 3 [Source:HGNC Symbol;Acc:HGNC:5019] None DBD Yes None None b Yes No No 1a1, Direct HQ evidence Laura Campitelli Pratyush Das Yes None $#ENSP00000350549#ENSG00000188620#ENST00000357878#Homeodomain# FALSE 1331 ENSG00000135100 HNF1A Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR006897;IPR006898;IPR006899;IPR009057;IPR010982;IPR023219; 6927 HNF1 homeobox A [Source:HGNC Symbol;Acc:HGNC:11621] 1IC8 DBD and Full not tested None Structure has two HNF1A proteins, both of which have two homeodomains a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:8373770;16603721;9047360 No 1a1, Direct HQ evidence Laura Campitelli Yimeng Yin Yes $#ENSG00000135100#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#ISS - GO_REF:0000024$#ENSG00000135100#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:11980910 $#ENSP00000257555#ENSG00000135100#ENST00000257555#Homeodomain#HNF-1A_C, HNF-1B_C, HNF-1_N, Telethonin$#ENSP00000443112#ENSG00000135100#ENST00000541395#Homeodomain#HNF-1A_C, HNF-1B_C, HNF-1_N, Telethonin$#ENSP00000438804#ENSG00000135100#ENST00000544413#Homeodomain#HNF-1A_C, HNF-1B_C, HNF-1_N, Telethonin$#ENSP00000481967#ENSG00000135100#ENST00000617366#Homeodomain#HNF-1_N, Telethonin$#ENSP00000476181#ENSG00000135100#ENST00000400024#Homeodomain#HNF-1B_C, HNF-1_N, Telethonin FALSE 1332 ENSG00000275410 HNF1B Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR006897;IPR006899;IPR009057;IPR010982;IPR023219 6928 HNF1 homeobox B [Source:HGNC Symbol;Acc:HGNC:11630] 2H8R DBD and Full not tested None Structure has two HNF1A proteins, both of which have two homeodomains a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:9774468 Yes 1a1, Direct HQ evidence Pratyush Das Laura Campitelli Yes $#ENSG00000275410#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:16297991$#ENSG00000275410#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019 $#ENSP00000477524#ENSG00000275410#ENST00000613727#Homeodomain#HNF-1B_C, HNF-1_N$#ENSP00000478682#ENSG00000275410#ENST00000617272#Homeodomain#HNF-1B_C, HNF-1_N$#ENSP00000480291#ENSG00000275410#ENST00000617811#Homeodomain#HNF-1B_C, HNF-1_N$#ENSP00000482711#ENSG00000275410#ENST00000621123#Homeodomain#HNF-1B_C, HNF-1_N FALSE 1333 ENSG00000215271 HOMEZ Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR008422;IPR009057;IPR024578 57594 homeobox and leucine zipper encoding [Source:HGNC Symbol;Acc:HGNC:20164] None DBD and Full Yes None None b Yes No Yes 1a1, Direct HQ evidence Pratyush Das Laura Campitelli Yes $#ENSG00000215271#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000350049#ENSG00000215271#ENST00000357460#Homeodomain#$#ENSP00000453979#ENSG00000215271#ENST00000561013#Homeodomain#$#ENSP00000475307#ENSG00000215271#ENST00000606731#Homeodomain# FALSE 1334 ENSG00000171476 HOPX Homeodomain No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Lacks conserved residues required for DNA binding (PMID: 24287901) IPR001356;IPR009057 84525 HOP homeobox [Source:HGNC Symbol;Acc:HGNC:24961] None not tested not tested None None x Yes No No 4a, two or more datasets predict it as a TF Laura Campitelli Pratyush Das Yes None $#ENSP00000315198#ENSG00000171476#ENST00000317745#Homeodomain#$#ENSP00000337330#ENSG00000171476#ENST00000337881#Homeodomain#$#ENSP00000424101#ENSG00000171476#ENST00000503639#Homeodomain#$#ENSP00000452003#ENSG00000171476#ENST00000556614#Homeodomain#$#ENSP00000370654#ENSG00000171476#ENST00000381255#Homeodomain#$#ENSP00000422175#ENSG00000171476#ENST00000508121#Homeodomain#$#ENSP00000452340#ENSG00000171476#ENST00000553379#Homeodomain#$#ENSP00000370659#ENSG00000171476#ENST00000381260#Homeodomain#$#ENSP00000452098#ENSG00000171476#ENST00000555760#Homeodomain#$#ENSP00000451794#ENSG00000171476#ENST00000556376#Homeodomain# FALSE 1335 ENSG00000105991 HOXA1 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR009057;IPR017970;IPR020479 3198 Homeobox A1 [Source:HGNC Symbol;Acc:HGNC:5099] None DBD and Full Yes None None a Yes No No 1a1, Direct HQ evidence Arttu Jolma Pratyush Das Yes None $#ENSP00000343246#ENSG00000105991#ENST00000343060#Homeodomain#$#ENSP00000347851#ENSG00000105991#ENST00000355633#Homeodomain# FALSE 1336 ENSG00000253293 HOXA10 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR009057;IPR017970;IPR020479 3206 homeobox A10 [Source:HGNC Symbol;Acc:HGNC:5100] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_Co-activation_PMIDS:14512427;15886193 Yes 1a1, Direct HQ evidence Pratyush Das Arttu Jolma Yes $#ENSG00000253293#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:21471217 $#ENSP00000283921#ENSG00000253293#ENST00000283921#Homeodomain#$#ENSP00000379633#ENSG00000253293#ENST00000396344#Homeodomain#$#ENSP00000479619#ENSG00000253293#ENST00000613671#Homeodomain# FALSE 1337 ENSG00000005073 HOXA11 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None Also forms heterodimers with MEIS and PBX. IPR001356;IPR009057;IPR017970;IPR020479;IPR021918; 3207 homeobox A11 [Source:HGNC Symbol;Acc:HGNC:5101] None DBD Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:9079637;12533430;14706073 No 1a1, Direct HQ evidence Jussi Taipale Mihai Albu Yes None $#ENSP00000006015#ENSG00000005073#ENST00000006015#Homeodomain#DUF3528$#ENSP00000448962#ENSG00000005073#ENST00000517402#Homeodomain#DUF3528 FALSE 1338 ENSG00000106031 HOXA13 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR009057;IPR017970;IPR022067 3209 homeobox A13 [Source:HGNC Symbol;Acc:HGNC:5102] 2LD5 DBD and Full Yes None NMR structure with a moderate affinity sequence a Yes No No 1a1, Direct HQ evidence Sam Lambert Arttu Jolma Yes None $#ENSP00000222753#ENSG00000106031#ENST00000222753#Homeodomain#HoxA13_N FALSE 1339 ENSG00000105996 HOXA2 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR001827;IPR009057;IPR017970;IPR020479; 3199 homeobox A2 [Source:HGNC Symbol;Acc:HGNC:5103] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:15634706 No 1a1, Direct HQ evidence Matt Weirauch Yimeng Yin Yes $#ENSG00000105996#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019 $#ENSP00000222718#ENSG00000105996#ENST00000222718#Homeodomain# FALSE 1340 ENSG00000105997 HOXA3 Homeodomain Yes Known motif Monomer or homomultimer 100 perc ID - in vitro None None IPR001356;IPR001827;IPR009057;IPR017970;IPR020479;IPR025281 3200 homeobox A3 [Source:HGNC Symbol;Acc:HGNC:5104] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:8096059;15914537 No 1a1, Direct HQ evidence Arttu Jolma Matt Weirauch Yes $#ENSG00000105997#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002 $#ENSP00000379640#ENSG00000105997#ENST00000396352#Homeodomain#DUF4074$#ENSP00000484411#ENSG00000105997#ENST00000612286#Homeodomain#DUF4074$#ENSP00000429426#ENSG00000105997#ENST00000522788#Homeodomain#$#ENSP00000430566#ENSG00000105997#ENST00000522456#Homeodomain# FALSE 1341 ENSG00000197576 HOXA4 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro Has a putative AT-hook None IPR001356;IPR001827;IPR009057;IPR017970;IPR017995;IPR020479 3201 homeobox A4 [Source:HGNC Symbol;Acc:HGNC:5105] None DBD Yes None None a Yes No No 1a1, Direct HQ evidence Jussi Taipale Arttu Jolma Yes $#ENSG00000197576#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002 $#ENSP00000353151#ENSG00000197576#ENST00000360046#Homeodomain#$#ENSP00000408845#ENSG00000197576#ENST00000428284#Homeodomain#$#ENSP00000448015#ENSG00000197576#ENST00000511914#Homeodomain#$#ENSP00000479166#ENSG00000197576#ENST00000610970#Homeodomain# FALSE 1342 ENSG00000106004 HOXA5 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR001827;IPR009057;IPR017970;IPR017995;IPR020479 3202 homeobox A5 [Source:HGNC Symbol;Acc:HGNC:5106] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:10879542 Yes 1a1, Direct HQ evidence Pratyush Das Tim Hughes Yes $#ENSG00000106004#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:10879542$#ENSG00000106004#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:10879542, PMID:16756717 $#ENSP00000222726#ENSG00000106004#ENST00000222726#Homeodomain# FALSE 1343 ENSG00000106006 HOXA6 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR001827;IPR009057;IPR017970;IPR017995;IPR020479 3203 homeobox A6 [Source:HGNC Symbol;Acc:HGNC:5107] None DBD and Full Yes None None a Yes No Yes 1a1, Direct HQ evidence Tim Hughes Jussi Taipale Yes $#ENSG00000106006#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002 $#ENSP00000222728#ENSG00000106006#ENST00000222728#Homeodomain# FALSE 1344 ENSG00000122592 HOXA7 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR001827;IPR009057;IPR017970;IPR017995;IPR020479 3204 homeobox A7 [Source:HGNC Symbol;Acc:HGNC:5108] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:7911971 Yes 1a1, Direct HQ evidence Sam Lambert Jussi Taipale Yes $#ENSG00000122592#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:11435435 $#ENSP00000242159#ENSG00000122592#ENST00000242159#Homeodomain#$#ENSP00000428563#ENSG00000122592#ENST00000519842#Homeodomain# FALSE 1345 ENSG00000078399 HOXA9 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR006711;IPR009057;IPR017112;IPR017970;IPR020479 442920 homeobox A9 [Source:HGNC Symbol;Acc:HGNC:5109] 1PUF DBD and Full Yes None Structure is a heterodimer of HoxA9 and Pbx1 a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:11042172 No 1a1, Direct HQ evidence Arttu Jolma Jussi Taipale Yes None $#ENSP00000343619#ENSG00000078399#ENST00000343483#Homeodomain#Hox9_act$#ENSP00000379634#ENSG00000078399#ENST00000396345#Homeodomain#Hox9_act FALSE 1346 ENSG00000120094 HOXB1 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR009057;IPR017970;IPR020479 3211 homeobox B1 [Source:HGNC Symbol;Acc:HGNC:5111] 1B72 DBD and Full not tested None Structure is a heterodimer of HOXB1 and PBX1 a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:7911971;9242495 No 1a1, Direct HQ evidence Yimeng Yin Arttu Jolma Yes None $#ENSP00000355140#ENSG00000120094#ENST00000239174#Homeodomain#$#ENSP00000459066#ENSG00000120094#ENST00000577092#Homeodomain# FALSE 1347 ENSG00000159184 HOXB13 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None Also forms heterodimers. IPR001356;IPR009057;IPR017970;IPR022067 10481 homeobox B13 [Source:HGNC Symbol;Acc:HGNC:5112] None DBD and Full Yes None None a Yes TF Gene_Transcription Factor Binding: tf co-factor binding_DNA Binding_PMIDS:15126340;15604291 No 1a1, Direct HQ evidence Pratyush Das Matt Weirauch Yes None $#ENSP00000290295#ENSG00000159184#ENST00000290295#Homeodomain#HoxA13_N FALSE 1348 ENSG00000173917 HOXB2 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR001827;IPR009057;IPR017970;IPR020479; 3212 homeobox B2 [Source:HGNC Symbol;Acc:HGNC:5113] None DBD and Full not tested None None a Yes TF Gene_DNA-Binding: sequence-specific_Transactivation_PMIDS:15289435 No 1a1, Direct HQ evidence Yimeng Yin Arttu Jolma Yes $#ENSG00000173917#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002 $#ENSP00000331741#ENSG00000173917#ENST00000330070#Homeodomain# FALSE 1349 ENSG00000120093 HOXB3 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR001827;IPR009057;IPR017970;IPR020479;IPR025281 3213 homeobox B3 [Source:HGNC Symbol;Acc:HGNC:5114] None DBD Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:9556594;12482716 No 1a1, Direct HQ evidence Matt Weirauch Laura Campitelli Yes $#ENSG00000120093#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002 $#ENSP00000308252#ENSG00000120093#ENST00000311626#Homeodomain#DUF4074$#ENSP00000417207#ENSG00000120093#ENST00000470495#Homeodomain#DUF4074$#ENSP00000418892#ENSG00000120093#ENST00000476342#Homeodomain#DUF4074$#ENSP00000449977#ENSG00000120093#ENST00000490677#Homeodomain#DUF4074$#ENSP00000419676#ENSG00000120093#ENST00000472863#Homeodomain#DUF4074$#ENSP00000418729#ENSG00000120093#ENST00000489475#Homeodomain#DUF4074$#ENSP00000420595#ENSG00000120093#ENST00000498678#Homeodomain#DUF4074$#ENSP00000446783#ENSG00000120093#ENST00000465120#Homeodomain# FALSE 1350 ENSG00000182742 HOXB4 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR001827;IPR009057;IPR017970;IPR017995;IPR020479 3214 homeobox B4 [Source:HGNC Symbol;Acc:HGNC:5115] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:12482716;12489992;15634700 No 1a1, Direct HQ evidence Jussi Taipale Sam Lambert Yes $#ENSG00000182742#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002 $#ENSP00000328928#ENSG00000182742#ENST00000332503#Homeodomain# FALSE 1351 ENSG00000120075 HOXB5 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR001827;IPR009057;IPR017970;IPR017995;IPR020479 3215 homeobox B5 [Source:HGNC Symbol;Acc:HGNC:5116] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:12897140 No 1a1, Direct HQ evidence Sam Lambert Laura Campitelli Yes $#ENSG00000120075#GO:0001205#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involv#IEA - GO_REF:0000019 $#ENSP00000239151#ENSG00000120075#ENST00000239151#Homeodomain# FALSE 1352 ENSG00000108511 HOXB6 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR001827;IPR009057;IPR017970;IPR017995;IPR020479 3216 homeobox B6 [Source:HGNC Symbol;Acc:HGNC:5117] None DBD and Full Yes None None a Yes Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0 No 1a1, Direct HQ evidence Yimeng Yin Arttu Jolma Yes $#ENSG00000108511#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002 $#ENSP00000225648#ENSG00000108511#ENST00000225648#Homeodomain#$#ENSP00000420009#ENSG00000108511#ENST00000484302#Homeodomain# FALSE 1353 ENSG00000260027 HOXB7 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR001827;IPR009057;IPR017970;IPR017995;IPR020479 3217 homeobox B7 [Source:HGNC Symbol;Acc:HGNC:5118] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:1357628;8756643 Yes 1a1, Direct HQ evidence Sam Lambert Arttu Jolma Yes $#ENSG00000260027#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:1678287 $#ENSP00000239165#ENSG00000260027#ENST00000239165#Homeodomain# FALSE 1354 ENSG00000120068 HOXB8 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000047;IPR001356;IPR001827;IPR009057;IPR017970;IPR020479 3218 homeobox B8 [Source:HGNC Symbol;Acc:HGNC:5119] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Other; TF PPI_PMIDS:11571641;15886193 No 1a1, Direct HQ evidence Arttu Jolma Laura Campitelli Yes $#ENSG00000120068#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002 $#ENSP00000239144#ENSG00000120068#ENST00000239144#Homeodomain#$#ENSP00000460659#ENSG00000120068#ENST00000576562#Homeodomain#$#ENSP00000460254#ENSG00000120068#ENST00000498634#Homeodomain# FALSE 1355 ENSG00000170689 HOXB9 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR006711;IPR009057;IPR017112;IPR017970;IPR020479 3219 homeobox B9 [Source:HGNC Symbol;Acc:HGNC:5120] None DBD and Full Yes None None a Yes TF Gene_Transcription Factor Binding: tf co-factor binding; DNA-Binding: sequence-specific_DNA Binding; TF PPI; Transactivation_PMIDS:1347944;9079637;10617598;11432851 No 1a1, Direct HQ evidence Sam Lambert Yimeng Yin Yes None $#ENSP00000309439#ENSG00000170689#ENST00000311177#Homeodomain#Hox9_act FALSE 1356 ENSG00000180818 HOXC10 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR009057;IPR017970;IPR020479 3226 homeobox C10 [Source:HGNC Symbol;Acc:HGNC:5122] None DBD and Full Yes None None a Yes TF Gene Candidate_DNA-Binding: sequence-specific_DNA Binding_PMIDS:10835276;10835276;12917416 No 1a1, Direct HQ evidence Sam Lambert Arttu Jolma Yes None $#ENSP00000307321#ENSG00000180818#ENST00000303460#Homeodomain#$#ENSP00000421946#ENSG00000180818#ENST00000515593#Homeodomain# FALSE 1357 ENSG00000123388 HOXC11 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR009057;IPR017970;IPR020479;IPR021918; 3227 homeobox C11 [Source:HGNC Symbol;Acc:HGNC:5123] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:9582375 Yes 1a1, Direct HQ evidence Matt Weirauch Laura Campitelli Yes $#ENSG00000123388#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:9582375 $#ENSP00000446680#ENSG00000123388#ENST00000546378#Homeodomain#DUF3528$#ENSP00000243082#ENSG00000123388#ENST00000243082#Homeodomain#DUF3528 FALSE 1358 ENSG00000123407 HOXC12 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR009057;IPR017970;IPR020479 3228 homeobox C12 [Source:HGNC Symbol;Acc:HGNC:5124] None DBD Yes None None a Yes Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0 No 1a1, Direct HQ evidence Sam Lambert Laura Campitelli Yes None $#ENSP00000243103#ENSG00000123407#ENST00000243103#Homeodomain# FALSE 1359 ENSG00000123364 HOXC13 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR009057;IPR017970;IPR022067 3229 homeobox C13 [Source:HGNC Symbol;Acc:HGNC:5125] None DBD Yes None None a Yes No No 1a1, Direct HQ evidence Yimeng Yin Pratyush Das Yes $#ENSG00000123364#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019 $#ENSP00000243056#ENSG00000123364#ENST00000243056#Homeodomain#HoxA13_N FALSE 1360 ENSG00000198353 HOXC4 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR001827;IPR009057;IPR017970;IPR017995;IPR020479 3221 homeobox C4 [Source:HGNC Symbol;Acc:HGNC:5126] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:15252056 No 1a1, Direct HQ evidence Sam Lambert Pratyush Das Yes $#ENSG00000198353#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002 $#ENSP00000305973#ENSG00000198353#ENST00000303406#Homeodomain#$#ENSP00000399808#ENSG00000198353#ENST00000430889#Homeodomain# FALSE 1361 ENSG00000172789 HOXC5 Homeodomain Yes Known motif Monomer or homomultimer 100 perc ID - in vitro None None IPR001356;IPR001827;IPR009057;IPR017970;IPR017995;IPR020479 3222 homeobox C5 [Source:HGNC Symbol;Acc:HGNC:5127] None DBD Yes None None a Yes No Yes 1a1, Direct HQ evidence Jussi Taipale Pratyush Das Yes $#ENSG00000172789#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002 $#ENSP00000309336#ENSG00000172789#ENST00000312492#Homeodomain# FALSE 1362 ENSG00000197757 HOXC6 Homeodomain Yes Known motif Monomer or homomultimer 100 perc ID - in vitro None None IPR001356;IPR001827;IPR009057;IPR017970;IPR017995;IPR020479 3223 homeobox C6 [Source:HGNC Symbol;Acc:HGNC:5128] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:8393570;8870653 No 1a1, Direct HQ evidence Arttu Jolma Sam Lambert Yes $#ENSG00000197757#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002 $#ENSP00000243108#ENSG00000197757#ENST00000243108#Homeodomain#$#ENSP00000377864#ENSG00000197757#ENST00000394331#Homeodomain#$#ENSP00000424124#ENSG00000197757#ENST00000504315#Homeodomain#$#ENSP00000423898#ENSG00000197757#ENST00000509328#Homeodomain# FALSE 1363 ENSG00000037965 HOXC8 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000047;IPR001356;IPR001827;IPR009057;IPR017970;IPR020479 3224 homeobox C8 [Source:HGNC Symbol;Acc:HGNC:5129] None DBD and Full Yes None None a Yes No No 1a1, Direct HQ evidence Jussi Taipale Sam Lambert Yes $#ENSG00000037965#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002 $#ENSP00000040584#ENSG00000037965#ENST00000040584#Homeodomain# FALSE 1364 ENSG00000180806 HOXC9 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR006711;IPR009057;IPR017112;IPR017970;IPR020479 3225 homeobox C9 [Source:HGNC Symbol;Acc:HGNC:5130] None DBD and Full Yes None None a Yes Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0 No 1a1, Direct HQ evidence Sam Lambert Jussi Taipale Yes None $#ENSP00000302836#ENSG00000180806#ENST00000303450#Homeodomain#Hox9_act$#ENSP00000423861#ENSG00000180806#ENST00000508190#Homeodomain#Hox9_act FALSE 1365 ENSG00000128645 HOXD1 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR009057;IPR017970;IPR020479 102465802 homeobox D1 [Source:HGNC Symbol;Acc:HGNC:5132] None DBD Yes None None a Yes TF Gene Candidate_DNA-Binding: sequence-specific_DNA Binding_PMIDS:11775067 No 1a1, Direct HQ evidence Pratyush Das Yimeng Yin Yes None $#ENSP00000328598#ENSG00000128645#ENST00000331462#Homeodomain# FALSE 1366 ENSG00000128710 HOXD10 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR009057;IPR017970;IPR020479 3236 homeobox D10 [Source:HGNC Symbol;Acc:HGNC:5133] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; TF PPI_PMIDS:11432851;14743444;15792957 Yes 1a1, Direct HQ evidence Arttu Jolma Laura Campitelli Yes $#ENSG00000128710#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019 $#ENSP00000249501#ENSG00000128710#ENST00000249501#Homeodomain# FALSE 1367 ENSG00000128713 HOXD11 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR009057;IPR017970;IPR020479;IPR021918; 3237 homeobox D11 [Source:HGNC Symbol;Acc:HGNC:5134] None DBD Yes None None a Yes No No 1a1, Direct HQ evidence Tim Hughes Pratyush Das Yes None $#ENSP00000249504#ENSG00000128713#ENST00000249504#Homeodomain#DUF3528$#ENSP00000480304#ENSG00000128713#ENST00000619244#Homeodomain#DUF3528 FALSE 1368 ENSG00000170178 HOXD12 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR009057;IPR017970;IPR020479 3238 homeobox D12 [Source:HGNC Symbol;Acc:HGNC:5135] None DBD and Full Yes None None a Yes TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:11036080 No 1a1, Direct HQ evidence Pratyush Das Laura Campitelli Yes None $#ENSP00000385132#ENSG00000170178#ENST00000404162#Homeodomain#$#ENSP00000385586#ENSG00000170178#ENST00000406506#Homeodomain# FALSE 1369 ENSG00000128714 HOXD13 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR009057;IPR017970;IPR022067 3239 homeobox D13 [Source:HGNC Symbol;Acc:HGNC:5136] None DBD Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:16314414 Yes 1a1, Direct HQ evidence Pratyush Das Matt Weirauch Yes $#ENSG00000128714#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000128714#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IMP - PMID:24789103$#ENSG00000128714#GO:0003700#sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024 $#ENSP00000376322#ENSG00000128714#ENST00000392539#Homeodomain#HoxA13_N FALSE 1370 ENSG00000128652 HOXD3 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR001827;IPR009057;IPR017970;IPR020479;IPR025281 3232 homeobox D3 [Source:HGNC Symbol;Acc:HGNC:5137] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:14610084 No 1a1, Direct HQ evidence Yimeng Yin Pratyush Das Yes $#ENSG00000128652#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002 $#ENSP00000249440#ENSG00000128652#ENST00000249440#Homeodomain#DUF4074$#ENSP00000392615#ENSG00000128652#ENST00000432796#Homeodomain#$#ENSP00000386498#ENSG00000128652#ENST00000410016#Homeodomain#DUF4074 FALSE 1371 ENSG00000170166 HOXD4 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR001827;IPR009057;IPR017970;IPR017995;IPR020479 3233 homeobox D4 [Source:HGNC Symbol;Acc:HGNC:5138] None DBD and Full not tested None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:1756725 No 1a1, Direct HQ evidence Yimeng Yin Sam Lambert Yes $#ENSG00000170166#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002 $#ENSP00000302548#ENSG00000170166#ENST00000306324#Homeodomain# FALSE 1372 ENSG00000175879 HOXD8 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR001827;IPR009057;IPR017970;IPR020479; 3234 homeobox D8 [Source:HGNC Symbol;Acc:HGNC:5139] None DBD Yes None None a Yes TF Gene Candidate_DNA-Binding: sequence-specific; Transcription Factor Binding: tf co-factor binding_Co-activation; TF PPI_PMIDS:8890171 Yes 1a1, Direct HQ evidence Pratyush Das Sam Lambert Yes $#ENSG00000175879#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IDA - PMID:1756725 $#ENSP00000409026#ENSG00000175879#ENST00000450510#Homeodomain#$#ENSP00000315949#ENSG00000175879#ENST00000313173#Homeodomain#$#ENSP00000406045#ENSG00000175879#ENST00000429017#Homeodomain#$#ENSP00000437431#ENSG00000175879#ENST00000544999#Homeodomain# FALSE 1373 ENSG00000128709 HOXD9 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR006711;IPR009057;IPR017112;IPR017970;IPR020479 3235 homeobox D9 [Source:HGNC Symbol;Acc:HGNC:5140] None DBD and Full not tested None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:8890171 Yes 1a1, Direct HQ evidence Yimeng Yin Sam Lambert Yes $#ENSG00000128709#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IDA - PMID:1756725 $#ENSP00000249499#ENSG00000128709#ENST00000249499#Homeodomain#Hox9_act FALSE 1374 ENSG00000170549 IRX1 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro Has a putative AT-hook None IPR001356;IPR003893;IPR008422;IPR009057;IPR017970; 79192 iroquois homeobox 1 [Source:HGNC Symbol;Acc:HGNC:14358] None DBD not tested None None a Yes TF Gene Candidate___PMIDS:0 No 1a1, Direct HQ evidence Jussi Taipale Arttu Jolma Yes None $#ENSP00000305244#ENSG00000170549#ENST00000302006#Homeodomain# FALSE 1375 ENSG00000170561 IRX2 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR003893;IPR008422;IPR009057;IPR017970; 153572 iroquois homeobox 2 [Source:HGNC Symbol;Acc:HGNC:14359] None DBD and Full Yes None None a Yes No No 1a1, Direct HQ evidence Sam Lambert Laura Campitelli Yes None $#ENSP00000307006#ENSG00000170561#ENST00000302057#Homeodomain#$#ENSP00000372056#ENSG00000170561#ENST00000382611#Homeodomain# FALSE 1376 ENSG00000177508 IRX3 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR003893;IPR008422;IPR009057;IPR017970; 79191 iroquois homeobox 3 [Source:HGNC Symbol;Acc:HGNC:14360] None DBD Yes None None a Yes Indeterminate - There is no evidence for or against this genes role as a TF__DNA Binding_PMIDS:16203991 No 1a1, Direct HQ evidence Sam Lambert Yimeng Yin Yes None $#ENSP00000331608#ENSG00000177508#ENST00000329734#Homeodomain#$#ENSP00000463991#ENSG00000177508#ENST00000558054#Homeodomain# FALSE 1377 ENSG00000113430 IRX4 Homeodomain Yes Known motif Monomer or homomultimer 100 perc ID - in vitro None None IPR001356;IPR003893;IPR008422;IPR009057;IPR017970; 50805 iroquois homeobox 4 [Source:HGNC Symbol;Acc:HGNC:6129] None DBD and Full Yes None None a Yes TF Gene Candidate__Other_PMIDS:10625552;11238910 No 1a1, Direct HQ evidence Arttu Jolma Yimeng Yin Yes None $#ENSP00000231357#ENSG00000113430#ENST00000231357#Homeodomain#$#ENSP00000423161#ENSG00000113430#ENST00000505790#Homeodomain#$#ENSP00000424235#ENSG00000113430#ENST00000513692#Homeodomain#$#ENSP00000482393#ENSG00000113430#ENST00000613726#Homeodomain#$#ENSP00000481396#ENSG00000113430#ENST00000622814#Homeodomain#$#ENSP00000421772#ENSG00000113430#ENST00000511126#Homeodomain#Homeobox_KN FALSE 1378 ENSG00000176842 IRX5 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR003893;IPR008422;IPR009057;IPR017970; 10265 iroquois homeobox 5 [Source:HGNC Symbol;Acc:HGNC:14361] None DBD Yes None None b Yes Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0 No 1a1, Direct HQ evidence Pratyush Das Arttu Jolma Yes None $#ENSP00000316250#ENSG00000176842#ENST00000320990#Homeodomain#$#ENSP00000483446#ENSG00000176842#ENST00000620085#Homeodomain#$#ENSP00000378132#ENSG00000176842#ENST00000394636#Homeodomain#$#ENSP00000453660#ENSG00000176842#ENST00000560154#Homeodomain# FALSE 1379 ENSG00000159387 IRX6 Homeodomain Yes Inferred motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR003893;IPR008422;IPR009057;IPR017970; 79190 iroquois homeobox 6 [Source:HGNC Symbol;Acc:HGNC:14675] None DBD and Full Yes None None a Yes TF Gene Candidate__Other_PMIDS:11335133 No 1a1, Direct HQ evidence Sam Lambert Arttu Jolma Yes None $#ENSP00000290552#ENSG00000159387#ENST00000290552#Homeodomain# FALSE 1380 ENSG00000016082 ISL1 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR001781;IPR009057;IPR017970 3670 ISL LIM homeobox 1 [Source:HGNC Symbol;Acc:HGNC:6132] None DBD and Full not tested None None a Yes TF Gene Candidate_DNA-Binding: sequence-specific_DNA Binding_PMIDS:15253934;16321656 No 1a1, Direct HQ evidence Laura Campitelli Matt Weirauch Yes $#ENSG00000016082#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019 $#ENSP00000230658#ENSG00000016082#ENST00000230658#Homeodomain#LIM$#ENSP00000422676#ENSG00000016082#ENST00000511384#Homeodomain#LIM FALSE 1381 ENSG00000159556 ISL2 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR001781;IPR009057;IPR017970 64843 ISL LIM homeobox 2 [Source:HGNC Symbol;Acc:HGNC:18524] None DBD Yes None None a Yes TF Gene Candidate_DNA-Binding: sequence-specific_DNA Binding_PMIDS:15048808 No 1a1, Direct HQ evidence Laura Campitelli Matt Weirauch Yes None $#ENSP00000290759#ENSG00000159556#ENST00000290759#Homeodomain#LIM FALSE 1382 ENSG00000175329 ISX Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR009057;IPR017970; 91464 intestine specific homeobox [Source:HGNC Symbol;Acc:HGNC:28084] None DBD and Full Yes None None b Yes No Yes 1a1, Direct HQ evidence Laura Campitelli Arttu Jolma Yes $#ENSG00000175329#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IEA - GO_REF:0000019 $#ENSP00000311492#ENSG00000175329#ENST00000308700#Homeodomain#$#ENSP00000386037#ENSG00000175329#ENST00000404699#Homeodomain# FALSE 1383 ENSG00000138136 LBX1 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000047;IPR001356;IPR009057;IPR017970 10660 ladybird homeobox 1 [Source:HGNC Symbol;Acc:HGNC:16960] None DBD Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:7909370;8645601;12358782;15528197 No 1a1, Direct HQ evidence Sam Lambert Arttu Jolma Yes $#ENSG00000138136#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019 $#ENSP00000359212#ENSG00000138136#ENST00000370193#Homeodomain# FALSE 1384 ENSG00000179528 LBX2 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR009057 85474 ladybird homeobox 2 [Source:HGNC Symbol;Acc:HGNC:15525] None DBD and Full Yes None None b Yes No No 1a1, Direct HQ evidence Sam Lambert Pratyush Das Yes None $#ENSP00000366789#ENSG00000179528#ENST00000377566#Homeodomain#$#ENSP00000417116#ENSG00000179528#ENST00000460508#Homeodomain#$#ENSP00000450229#ENSG00000179528#ENST00000341396#Homeodomain# FALSE 1385 ENSG00000213921 LEUTX Homeodomain Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR001356;IPR009057;IPR017970; 342900 leucine twenty homeobox [Source:HGNC Symbol;Acc:HGNC:31953] None DBD not tested None PMID:27412763 Expressed in early embryo as transcripts that contain a full homeodomain b Yes No No 3a, decent circumstantial evidence for its role as Pratyush Das Sam Lambert Yes None $#ENSP00000380053#ENSG00000213921#ENST00000396841#Homeodomain# FALSE 1386 ENSG00000273706 LHX1 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR001781;IPR009057;IPR017970 3975 LIM homeobox 1 [Source:HGNC Symbol;Acc:HGNC:6593] None DBD Yes None None b Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:10926781 No 1a1, Direct HQ evidence Pratyush Das Laura Campitelli Yes $#ENSG00000273706#GO:0003700#sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024 $#ENSP00000477829#ENSG00000273706#ENST00000614239#Homeodomain#LIM$#ENSP00000481496#ENSG00000273706#ENST00000621767#Homeodomain# FALSE 1387 ENSG00000106689 LHX2 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro Has a putative AT-hook None IPR001356;IPR001781;IPR009057;IPR017970 9355 LIM homeobox 2 [Source:HGNC Symbol;Acc:HGNC:6594] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:7513049;10593900 No 1a1, Direct HQ evidence Matt Weirauch Tim Hughes Yes None $#ENSP00000362717#ENSG00000106689#ENST00000373615#Homeodomain#LIM$#ENSP00000394978#ENSG00000106689#ENST00000446480#Homeodomain#LIM$#ENSP00000476200#ENSG00000106689#ENST00000488674#Homeodomain#$#ENSP00000453448#ENSG00000106689#ENST00000560961#Homeodomain#LIM FALSE 1388 ENSG00000107187 LHX3 Homeodomain Yes Known motif Monomer or homomultimer 100 perc ID - in vitro None None IPR001356;IPR001781;IPR009057;IPR017970 8022 LIM homeobox 3 [Source:HGNC Symbol;Acc:HGNC:6595] None DBD Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:15271874 No 1a1, Direct HQ evidence Tim Hughes Yimeng Yin Yes None $#ENSP00000360811#ENSG00000107187#ENST00000371746#Homeodomain#LIM$#ENSP00000360813#ENSG00000107187#ENST00000371748#Homeodomain#LIM$#ENSP00000483080#ENSG00000107187#ENST00000619587#Homeodomain#LIM FALSE 1389 ENSG00000121454 LHX4 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR001781;IPR009057;IPR017970 89884 LIM homeobox 4 [Source:HGNC Symbol;Acc:HGNC:21734] None DBD and Full Yes None None a Yes TF Gene Candidate_DNA-Binding: sequence-specific_Other; Transactivation_PMIDS:12118377;15998782 No 1a1, Direct HQ evidence Sam Lambert Matt Weirauch Yes None $#ENSP00000263726#ENSG00000121454#ENST00000263726#Homeodomain#LIM FALSE 1390 ENSG00000089116 LHX5 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR001781;IPR009057;IPR017970 64211 LIM homeobox 5 [Source:HGNC Symbol;Acc:HGNC:14216] None DBD and Full Yes None None b Yes TF Gene Candidate_DNA-Binding: sequence-specific__PMIDS:0 No 1a1, Direct HQ evidence Pratyush Das Matt Weirauch Yes None $#ENSP00000261731#ENSG00000089116#ENST00000261731#Homeodomain#LIM FALSE 1391 ENSG00000106852 LHX6 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR001781;IPR009057;IPR017970 26468 LIM homeobox 6 [Source:HGNC Symbol;Acc:HGNC:21735] None DBD and Full Yes None None a Yes Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0 Yes 1a1, Direct HQ evidence Pratyush Das Arttu Jolma Yes $#ENSG00000106852#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:10393337 $#ENSP00000340137#ENSG00000106852#ENST00000340587#Homeodomain#LIM$#ENSP00000362859#ENSG00000106852#ENST00000373754#Homeodomain#LIM$#ENSP00000362860#ENSG00000106852#ENST00000373755#Homeodomain#LIM$#ENSP00000377854#ENSG00000106852#ENST00000394319#Homeodomain#LIM$#ENSP00000452811#ENSG00000106852#ENST00000464484#Homeodomain#$#ENSP00000453798#ENSG00000106852#ENST00000482062#Homeodomain#$#ENSP00000441464#ENSG00000106852#ENST00000541397#Homeodomain#LIM$#ENSP00000475927#ENSG00000106852#ENST00000559895#Homeodomain# FALSE 1392 ENSG00000162624 LHX8 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR001781;IPR009057;IPR017970 431707 LIM homeobox 8 [Source:HGNC Symbol;Acc:HGNC:28838] None DBD and Full Yes None None b Yes Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0 No 1a1, Direct HQ evidence Yimeng Yin Pratyush Das Yes None $#ENSP00000294638#ENSG00000162624#ENST00000294638#Homeodomain#DUF2175, LIM$#ENSP00000348597#ENSG00000162624#ENST00000356261#Homeodomain#DUF2175, LIM FALSE 1393 ENSG00000143355 LHX9 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro Has a putative AT-hook None IPR001356;IPR001781;IPR009057;IPR017970 56956 LIM homeobox 9 [Source:HGNC Symbol;Acc:HGNC:14222] None DBD and Full Yes None None a Yes Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0 No 1a1, Direct HQ evidence Yimeng Yin Arttu Jolma Yes None $#ENSP00000356357#ENSG00000143355#ENST00000367387#Homeodomain#LIM$#ENSP00000356360#ENSG00000143355#ENST00000367390#Homeodomain#LIM$#ENSP00000482898#ENSG00000143355#ENST00000475727#Homeodomain#$#ENSP00000356358#ENSG00000143355#ENST00000367388#Homeodomain#$#ENSP00000483170#ENSG00000143355#ENST00000606127#Homeodomain# FALSE 1394 ENSG00000162761 LMX1A Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR001781;IPR009057;IPR017970 4009 LIM homeobox transcription factor 1 alpha [Source:HGNC Symbol;Acc:HGNC:6653] None DBD and Full Yes None None a Yes Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0 No 1a1, Direct HQ evidence Jussi Taipale Arttu Jolma Yes None $#ENSP00000294816#ENSG00000162761#ENST00000294816#Homeodomain#LIM$#ENSP00000340226#ENSG00000162761#ENST00000342310#Homeodomain#LIM$#ENSP00000356868#ENSG00000162761#ENST00000367893#Homeodomain#LIM FALSE 1395 ENSG00000136944 LMX1B Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR001781;IPR009057;IPR017970 4010 LIM homeobox transcription factor 1 beta [Source:HGNC Symbol;Acc:HGNC:6654] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_Transactivation_PMIDS:10767331;11956245;1358758;15785774 Yes 1a1, Direct HQ evidence Jussi Taipale Pratyush Das Yes $#ENSG00000136944#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:10767331 $#ENSP00000347684#ENSG00000136944#ENST00000355497#Homeodomain#LIM$#ENSP00000362573#ENSG00000136944#ENST00000373474#Homeodomain#LIM$#ENSP00000436930#ENSG00000136944#ENST00000526117#Homeodomain#LIM$#ENSP00000453580#ENSG00000136944#ENST00000561065#Homeodomain#LIM FALSE 1396 ENSG00000143995 MEIS1 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR008422;IPR009057; 4211 Meis homeobox 1 [Source:HGNC Symbol;Acc:HGNC:7000] 4XRM DBD Yes None MEIS1 homodimer a Yes TF Gene_Transcription Factor Binding: tf co-factor binding_Co-activation_PMIDS:12609849;16648484 No 1a1, Direct HQ evidence Laura Campitelli Arttu Jolma Yes $#ENSG00000143995#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000143995#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019 $#ENSP00000272369#ENSG00000143995#ENST00000272369#Homeodomain#Meis_PKNOX_N$#ENSP00000475161#ENSG00000143995#ENST00000488550#Homeodomain#Meis_PKNOX_N$#ENSP00000440571#ENSG00000143995#ENST00000495021#Homeodomain#Meis_PKNOX_N FALSE 1397 ENSG00000134138 MEIS2 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR008422;IPR009057; 4212 Meis homeobox 2 [Source:HGNC Symbol;Acc:HGNC:7001] None DBD and Full not tested None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:9811838;10764806 Yes 1a1, Direct HQ evidence Pratyush Das Matt Weirauch Yes $#ENSG00000134138#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:10764806$#ENSG00000134138#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:10764806 $#ENSP00000341400#ENSG00000134138#ENST00000338564#Homeodomain#Meis_PKNOX_N$#ENSP00000339549#ENSG00000134138#ENST00000340545#Homeodomain#Meis_PKNOX_N$#ENSP00000404185#ENSG00000134138#ENST00000424352#Homeodomain#Meis_PKNOX_N$#ENSP00000453793#ENSG00000134138#ENST00000561208#Homeodomain#Meis_PKNOX_N$#ENSP00000380745#ENSG00000134138#ENST00000397620#Homeodomain#Meis_PKNOX_N$#ENSP00000453390#ENSG00000134138#ENST00000559085#Homeodomain#Meis_PKNOX_N$#ENSP00000452874#ENSG00000134138#ENST00000560617#Homeodomain#Meis_PKNOX_N$#ENSP00000475660#ENSG00000134138#ENST00000606653#Homeodomain#Meis_PKNOX_N$#ENSP00000475899#ENSG00000134138#ENST00000607277#Homeodomain#Meis_PKNOX_N FALSE 1398 ENSG00000105419 MEIS3 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR008422;IPR009057; 56917 Meis homeobox 3 [Source:HGNC Symbol;Acc:HGNC:29537] None DBD not tested None None a Yes No No 1a1, Direct HQ evidence Matt Weirauch Jussi Taipale Yes $#ENSG00000105419#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019 $#ENSP00000388667#ENSG00000105419#ENST00000441740#Homeodomain#Meis_PKNOX_N$#ENSP00000453757#ENSG00000105419#ENST00000560245#Homeodomain#Meis_PKNOX_N$#ENSP00000453307#ENSG00000105419#ENST00000561293#Homeodomain#Meis_PKNOX_N$#ENSP00000476248#ENSG00000105419#ENST00000557833#Homeodomain#Meis_PKNOX_N$#ENSP00000452854#ENSG00000105419#ENST00000559524#Homeodomain#Meis_PKNOX_N$#ENSP00000453934#ENSG00000105419#ENST00000561096#Homeodomain#Meis_PKNOX_N$#ENSP00000475941#ENSG00000105419#ENST00000607695#Homeodomain# FALSE 1399 ENSG00000005102 MEOX1 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR009057;IPR017970;IPR020479 4222 mesenchyme homeobox 1 [Source:HGNC Symbol;Acc:HGNC:7013] None DBD and Full Yes None None b Yes TF Gene_DNA-Binding: sequence-specific_Co-activation; DNA Binding; TF PPI; Transactivation_PMIDS:15024065 Yes 1a1, Direct HQ evidence Tim Hughes Jussi Taipale Yes $#ENSG00000005102#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000005102#GO:0003700#sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024 $#ENSP00000321684#ENSG00000005102#ENST00000318579#Homeodomain#$#ENSP00000328678#ENSG00000005102#ENST00000329168#Homeodomain#$#ENSP00000449049#ENSG00000005102#ENST00000549132#Homeodomain#$#ENSP00000377271#ENSG00000005102#ENST00000393661#Homeodomain# FALSE 1400 ENSG00000106511 MEOX2 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR009057;IPR017970;IPR020479 4223 mesenchyme homeobox 2 [Source:HGNC Symbol;Acc:HGNC:7014] None DBD and Full not tested None None a Yes TF Gene_DNA-Binding: sequence-specific_TF PPI_PMIDS:16335786;17074759 Yes 1a1, Direct HQ evidence Arttu Jolma Sam Lambert Yes $#ENSG00000106511#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:17074759 | IMP - PMID:17074759$#ENSG00000106511#GO:0001205#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involv#IDA - PMID:17074759 | IMP - PMID:17074759$#ENSG00000106511#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:22206000 $#ENSP00000262041#ENSG00000106511#ENST00000262041#Homeodomain# FALSE 1401 ENSG00000185155 MIXL1 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR009057;IPR017970; 83881 Mix paired-like homeobox [Source:HGNC Symbol;Acc:HGNC:13363] None DBD and Full not tested None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Other; Transactivation_PMIDS:12117810 Yes 1a1, Direct HQ evidence Yimeng Yin Pratyush Das Yes $#ENSG00000185155#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#ISS - GO_REF:0000024, PMID:22164283$#ENSG00000185155#GO:0001205#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involv#ISS - GO_REF:0000024, PMID:22164283 $#ENSP00000355775#ENSG00000185155#ENST00000366810#Homeodomain#$#ENSP00000442439#ENSG00000185155#ENST00000542034#Homeodomain# FALSE 1402 ENSG00000150051 MKX Homeodomain Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Orthologous protein from fly is a TF that binds NWACA (PMID: 22923612). IPR001356;IPR008422;IPR009057;IPR017970 283078 mohawk homeobox [Source:HGNC Symbol;Acc:HGNC:23729] None DBD and Full not tested None PMID:22923612 for the B1H b Yes No No 1a1, Direct HQ evidence Sam Lambert Arttu Jolma Yes None $#ENSP00000364946#ENSG00000150051#ENST00000375790#Homeodomain#$#ENSP00000400896#ENSG00000150051#ENST00000419761#Homeodomain#$#ENSP00000452751#ENSG00000150051#ENST00000460919#Homeodomain#$#ENSP00000453746#ENSG00000150051#ENST00000561227#Homeodomain# FALSE 1403 ENSG00000130675 MNX1 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR009057;IPR017970;IPR020479 3110 motor neuron and pancreas homeobox 1 [Source:HGNC Symbol;Acc:HGNC:4979] None DBD not tested None None b Yes No Yes 1a1, Direct HQ evidence Pratyush Das Jussi Taipale Yes $#ENSG00000130675#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:9843207 $#ENSP00000252971#ENSG00000130675#ENST00000252971#Homeodomain#$#ENSP00000416458#ENSG00000130675#ENST00000425745#Homeodomain#$#ENSP00000401158#ENSG00000130675#ENST00000428439#Homeodomain#$#ENSP00000475129#ENSG00000130675#ENST00000469500#Homeodomain#$#ENSP00000474286#ENSG00000130675#ENST00000479817#Homeodomain#$#ENSP00000438552#ENSG00000130675#ENST00000543409#Homeodomain# FALSE 1404 ENSG00000163132 MSX1 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR009057;IPR017970;IPR020479 4487 msh homeobox 1 [Source:HGNC Symbol;Acc:HGNC:7391] 1IG7 DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:15192231;17030628 No 1a1, Direct HQ evidence Laura Campitelli Yimeng Yin Yes $#ENSG00000163132#GO:0000982#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000163132#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IEA - GO_REF:0000019$#ENSG00000163132#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IEA - GO_REF:0000019 $#ENSP00000372170#ENSG00000163132#ENST00000382723#Homeodomain# FALSE 1405 ENSG00000120149 MSX2 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR009057;IPR017970;IPR020479 4488 msh homeobox 2 [Source:HGNC Symbol;Acc:HGNC:7392] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_Transactivation_PMIDS:9368026;11798166;9265625;12750290 No 1a1, Direct HQ evidence Pratyush Das Tim Hughes Yes $#ENSG00000120149#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IEA - GO_REF:0000019$#ENSG00000120149#GO:0032792#negative regulation of CREB transcription factor activity#IEA - GO_REF:0000019 $#ENSP00000239243#ENSG00000120149#ENST00000239243#Homeodomain#$#ENSP00000427425#ENSG00000120149#ENST00000507785#Homeodomain# FALSE 1406 ENSG00000111704 NANOG Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR009057;IPR017970; 79923 Nanog homeobox [Source:HGNC Symbol;Acc:HGNC:20857] None DBD and Full Yes None None a Yes No Yes 1a1, Direct HQ evidence Tim Hughes Laura Campitelli Yes $#ENSG00000111704#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:16153702 $#ENSP00000229307#ENSG00000111704#ENST00000229307#Homeodomain#$#ENSP00000435288#ENSG00000111704#ENST00000526286#Homeodomain#$#ENSP00000444434#ENSG00000111704#ENST00000541267#Homeodomain# FALSE 1407 ENSG00000205857 NANOGNB Homeodomain Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR001356;IPR009057 360030 NANOG neighbor homeobox [Source:HGNC Symbol;Acc:HGNC:24958] None not tested Yes None None x Yes No No 4a, two or more datasets predict it as a TF Yimeng Yin Arttu Jolma Yes None $#ENSP00000371553#ENSG00000205857#ENST00000382119#Homeodomain# FALSE 1408 ENSG00000255192 NANOGP8 Homeodomain Yes Known motif Monomer or homomultimer 100 perc ID - in vitro None Listed as a pseudogene, but it encodes two protein products IPR001356;IPR009057;IPR017970 None Nanog homeobox pseudogene 8 [Source:HGNC Symbol;Acc:HGNC:23106] 4RBO Full not tested None Crystal structure shows strong protein-protein interaction between the monomers No Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:12787504;15502159;15502159;16153702 No 1a1, Direct HQ evidence Pratyush Das Jussi Taipale Yes None $##ENSG00000255192##Other# FALSE 1409 ENSG00000235608 NKX1-1 Homeodomain Yes Known motif Monomer or homomultimer 100 perc ID - in vitro None None IPR001356;IPR009057;IPR017970;IPR020479 54729 NK1 homeobox 1 [Source:HGNC Symbol;Acc:HGNC:24975] None not tested Yes None None b Yes No No 1a1, Direct HQ evidence Pratyush Das Arttu Jolma Yes None $#ENSP00000407978#ENSG00000235608#ENST00000422806#Homeodomain# FALSE 1410 ENSG00000229544 NKX1-2 Homeodomain Yes Known motif Monomer or homomultimer 100 perc ID - in vitro None None IPR001356;IPR009057;IPR017970;IPR020479 390010 NK1 homeobox 2 [Source:HGNC Symbol;Acc:HGNC:31652] None not tested not tested None None No Yes Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0 No 1a1, Direct HQ evidence Sam Lambert Pratyush Das Yes None $#ENSP00000451945#ENSG00000229544#ENST00000451024#Homeodomain# FALSE 1411 ENSG00000136352 NKX2-1 Homeodomain Yes Known motif Monomer or homomultimer 100 perc ID - in vitro None None IPR001356;IPR009057;IPR017970;IPR020479 7080 NK2 homeobox 1 [Source:HGNC Symbol;Acc:HGNC:11825] None DBD not tested None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:1976511;11914369 Yes 1a1, Direct HQ evidence Laura Campitelli Jussi Taipale Yes $#ENSG00000136352#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:16960125, PMID:7559607, PMID:7713914 | $#ENSG00000136352#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019 $#ENSP00000346879#ENSG00000136352#ENST00000354822#Homeodomain#$#ENSP00000429607#ENSG00000136352#ENST00000498187#Homeodomain#$#ENSP00000429519#ENSG00000136352#ENST00000522719#Homeodomain#$#ENSP00000449302#ENSG00000136352#ENST00000546983#Homeodomain# FALSE 1412 ENSG00000125820 NKX2-2 Homeodomain Yes Known motif Monomer or homomultimer 100 perc ID - in vitro None None IPR001356;IPR009057;IPR017970;IPR020479 4821 NK2 homeobox 2 [Source:HGNC Symbol;Acc:HGNC:7835] None DBD and Full Yes None None b Yes No Yes 1a1, Direct HQ evidence Arttu Jolma Laura Campitelli Yes $#ENSG00000125820#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019$#ENSG00000125820#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024 $#ENSP00000366347#ENSG00000125820#ENST00000377142#Homeodomain# FALSE 1413 ENSG00000119919 NKX2-3 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR009057;IPR017970;IPR020479 159296 NK2 homeobox 3 [Source:HGNC Symbol;Acc:HGNC:7836] None DBD and Full Yes None None a Yes TF Gene Candidate_DNA-Binding: sequence-specific_Transactivation_PMIDS:10790368;12141427 No 1a1, Direct HQ evidence Arttu Jolma Tim Hughes Yes None $#ENSP00000342828#ENSG00000119919#ENST00000344586#Homeodomain#$#ENSP00000479692#ENSG00000119919#ENST00000622383#Homeodomain# FALSE 1414 ENSG00000125816 NKX2-4 Homeodomain Yes Known motif Monomer or homomultimer 100 perc ID - in vitro None None IPR001356;IPR009057;IPR017970;IPR020479 644524 NK2 homeobox 4 [Source:HGNC Symbol;Acc:HGNC:7837] None DBD Yes None None b Yes No No 1a1, Direct HQ evidence Yimeng Yin Matt Weirauch Yes None $#ENSP00000345147#ENSG00000125816#ENST00000351817#Homeodomain# FALSE 1415 ENSG00000183072 NKX2-5 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR009057;IPR017970;IPR020479 1482 NK2 homeobox 5 [Source:HGNC Symbol;Acc:HGNC:2488] 3RKQ DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; TF PPI; Transactivation_PMIDS:9584181;10318839 Yes 1a1, Direct HQ evidence Sam Lambert Arttu Jolma Yes $#ENSG00000183072#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IMP - PMID:15649947$#ENSG00000183072#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IDA - PMID:19578358$#ENSG00000183072#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:10948187, PMID:11431700, PMID:9312027, $#ENSG00000183072#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019 $#ENSP00000327758#ENSG00000183072#ENST00000329198#Homeodomain#$#ENSP00000395378#ENSG00000183072#ENST00000424406#Homeodomain#$#ENSP00000427906#ENSG00000183072#ENST00000521848#Homeodomain#$#ENSP00000429905#ENSG00000183072#ENST00000517440#Homeodomain# FALSE 1416 ENSG00000180053 NKX2-6 Homeodomain Yes Inferred motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR009057;IPR017970;IPR020479 137814 NK2 homeobox 6 [Source:HGNC Symbol;Acc:HGNC:32940] None DBD Yes None None b Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:17263687 Yes 1a1, Direct HQ evidence Arttu Jolma Jussi Taipale Yes $#ENSG00000180053#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:15649947 $#ENSP00000320089#ENSG00000180053#ENST00000325017#Homeodomain# FALSE 1417 ENSG00000136327 NKX2-8 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR009057;IPR017970;IPR020479 26257 NK2 homeobox 8 [Source:HGNC Symbol;Acc:HGNC:16364] None DBD and Full Yes None None b Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:12167706 Yes 1a1, Direct HQ evidence Jussi Taipale Matt Weirauch Yes $#ENSG00000136327#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:12167706$#ENSG00000136327#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:9446603 $#ENSP00000258829#ENSG00000136327#ENST00000258829#Homeodomain# FALSE 1418 ENSG00000167034 NKX3-1 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR009057;IPR017970;IPR020479 4824 NK3 homeobox 1 [Source:HGNC Symbol;Acc:HGNC:7838] None DBD Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:10993896 Yes 1a1, Direct HQ evidence Matt Weirauch Yimeng Yin Yes $#ENSG00000167034#GO:0000983#RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019$#ENSG00000167034#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:20855495 | NAS - PMID:11137288$#ENSG00000167034#GO:0004882#androgen receptor activity#IDA - PMID:19886863 $#ENSP00000370253#ENSG00000167034#ENST00000380871#Homeodomain#$#ENSP00000429729#ENSG00000167034#ENST00000523261#Homeodomain# FALSE 1419 ENSG00000109705 NKX3-2 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR009057;IPR017970;IPR020479 579 NK3 homeobox 2 [Source:HGNC Symbol;Acc:HGNC:951] None DBD not tested None None b Yes TF Gene_Transcription Factor Binding: tf co-factor binding; DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:9256352;12746429 No 1a1, Direct HQ evidence Yimeng Yin Pratyush Das Yes $#ENSG00000109705#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019 $#ENSP00000371875#ENSG00000109705#ENST00000382438#Homeodomain# FALSE 1420 ENSG00000163623 NKX6-1 Homeodomain Yes Known motif Monomer or homomultimer 100 perc ID - in vitro None None IPR000047;IPR001356;IPR009057;IPR017970;IPR020479; 4825 NK6 homeobox 1 [Source:HGNC Symbol;Acc:HGNC:7839] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:15883383 Yes 1a1, Direct HQ evidence Jussi Taipale Arttu Jolma Yes $#ENSG00000163623#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000163623#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024 $#ENSP00000295886#ENSG00000163623#ENST00000295886#Homeodomain#$#ENSP00000449761#ENSG00000163623#ENST00000515820#Homeodomain# FALSE 1421 ENSG00000148826 NKX6-2 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro Has a putative AT-hook None IPR000047;IPR001356;IPR009057;IPR017970;IPR020479; 84504 NK6 homeobox 2 [Source:HGNC Symbol;Acc:HGNC:19321] None DBD and Full not tested None None a Yes TF Gene Candidate_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:8096811 Yes 1a1, Direct HQ evidence Laura Campitelli Matt Weirauch Yes $#ENSG00000148826#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000148826#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:11210186 $#ENSP00000357581#ENSG00000148826#ENST00000368592#Homeodomain# FALSE 1422 ENSG00000165066 NKX6-3 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000047;IPR001356;IPR009057;IPR017970;IPR020479; 157848 NK6 homeobox 3 [Source:HGNC Symbol;Acc:HGNC:26328] None DBD Yes None None c Yes No No 1a1, Direct HQ evidence Arttu Jolma Pratyush Das Yes None $#ENSP00000429553#ENSG00000165066#ENST00000524115#Homeodomain#$#ENSP00000428361#ENSG00000165066#ENST00000518699#Homeodomain# FALSE 1423 ENSG00000106410 NOBOX Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR009057 135935 NOBOX oogenesis homeobox [Source:HGNC Symbol;Acc:HGNC:22448] None DBD Yes None None b Yes Indeterminate - There is no evidence for or against this genes role as a TF__DNA Binding_PMIDS:8096059 Yes 1a1, Direct HQ evidence Sam Lambert Yimeng Yin Yes $#ENSG00000106410#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019 $#ENSP00000419457#ENSG00000106410#ENST00000467773#Homeodomain#$#ENSP00000419565#ENSG00000106410#ENST00000483238#Homeodomain# FALSE 1424 ENSG00000214513 NOTO Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR009057 344022 notochord homeobox [Source:HGNC Symbol;Acc:HGNC:31839] None DBD Yes None None a Yes Indeterminate - There is no evidence for or against this genes role as a TF__DNA Binding_PMIDS:7477317;15231714 No 1a1, Direct HQ evidence Pratyush Das Laura Campitelli Yes None $#ENSP00000381486#ENSG00000214513#ENST00000398468#Homeodomain# FALSE 1425 ENSG00000171540 OTP Homeodomain Yes Known motif Monomer or homomultimer 100 perc ID - in vitro None None IPR000047;IPR001356;IPR003654;IPR009057;IPR017970; 23440 orthopedia homeobox [Source:HGNC Symbol;Acc:HGNC:8518] None DBD Yes None None b Yes No No 1a1, Direct HQ evidence Laura Campitelli Jussi Taipale Yes None $#ENSP00000302814#ENSG00000171540#ENST00000306422#Homeodomain#OAR FALSE 1426 ENSG00000115507 OTX1 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR003025;IPR003026;IPR009057;IPR013851;IPR017970 5013 orthodenticle homeobox 1 [Source:HGNC Symbol;Acc:HGNC:8521] None DBD and Full Yes None None a Yes No Yes 1a1, Direct HQ evidence Tim Hughes Pratyush Das Yes $#ENSG00000115507#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:18849347 $#ENSP00000282549#ENSG00000115507#ENST00000282549#Homeodomain#TF_Otx$#ENSP00000355631#ENSG00000115507#ENST00000366671#Homeodomain#TF_Otx FALSE 1427 ENSG00000165588 OTX2 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR003022;IPR003025;IPR009057;IPR013851;IPR017970 5015 orthodenticle homeobox 2 [Source:HGNC Symbol;Acc:HGNC:8522] None DBD and Full Yes None None a Yes TF Gene Candidate_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:12559959;14625556 Yes 1a1, Direct HQ evidence Arttu Jolma Matt Weirauch Yes $#ENSG00000165588#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:12559959, PMID:20530484 $#ENSP00000343819#ENSG00000165588#ENST00000339475#Homeodomain#TF_Otx$#ENSP00000386185#ENSG00000165588#ENST00000408990#Homeodomain#TF_Otx$#ENSP00000474486#ENSG00000165588#ENST00000554788#Homeodomain#$#ENSP00000451357#ENSG00000165588#ENST00000554845#Homeodomain#TF_Otx$#ENSP00000452336#ENSG00000165588#ENST00000555006#Homeodomain#TF_Otx FALSE 1428 ENSG00000185630 PBX1 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR005542;IPR009057;IPR017970 5087 PBX homeobox 1 [Source:HGNC Symbol;Acc:HGNC:8632] 1LFU DBD and Full Yes Obligate_Multimer Can bind weakly as a homodimer or monomer (structure is an NMR-model of monomer) but prefers heterodimers with HOX-proteins a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:8183558;9315626;12529389 Yes 1a1, Direct HQ evidence Laura Campitelli Sam Lambert Yes $#ENSG00000185630#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000185630#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:10500199 $#ENSP00000356872#ENSG00000185630#ENST00000367897#Homeodomain#PBC$#ENSP00000405890#ENSG00000185630#ENST00000420696#Homeodomain#PBC$#ENSP00000439943#ENSG00000185630#ENST00000540236#Homeodomain#PBC$#ENSP00000473998#ENSG00000185630#ENST00000485769#Homeodomain#PBC$#ENSP00000485692#ENSG00000185630#ENST00000627490#Homeodomain#PBC FALSE 1429 ENSG00000204304 PBX2 Homeodomain Yes Known motif Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain High sequence similarity to PBX1, PBX4, and drosophila exd, which have in vitro-derived motifs IPR001356;IPR005542;IPR009057;IPR017970 5089 PBX homeobox 2 [Source:HGNC Symbol;Acc:HGNC:8633] None Full not tested Obligate_Multimer Obligate heterodimer with e.g. Classical homeodomains a Yes No No 2a1, Lower confidence direct evidence Arttu Jolma Laura Campitelli Yes None $#ENSP00000364190#ENSG00000204304#ENST00000375050#Homeodomain#PBC FALSE 1430 ENSG00000167081 PBX3 Homeodomain Yes Known motif Monomer or homomultimer In vivo/Misc source None High sequence similarity to PBX1, PBX4, and drosophila exd, which have in vitro-derived motifs IPR001356;IPR005542;IPR008422;IPR009057;IPR017970; 5090 PBX homeobox 3 [Source:HGNC Symbol;Acc:HGNC:8634] None DBD and Full not tested Obligate_Multimer Obligate heterodimer with e.g. Classical homeodomains a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:15466398 No 2a1, Lower confidence direct evidence Jussi Taipale Arttu Jolma Yes $#ENSG00000167081#GO:0001205#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involv#IEA - GO_REF:0000019 $#ENSP00000362588#ENSG00000167081#ENST00000373489#Homeodomain#PBC$#ENSP00000387456#ENSG00000167081#ENST00000447726#Homeodomain#PBC FALSE 1431 ENSG00000105717 PBX4 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR005542;IPR009057; 80714 PBX homeobox 4 [Source:HGNC Symbol;Acc:HGNC:13403] None DBD and Full not tested Obligate_Multimer Obligate heterodimer with e.g. Classical homeodomains b Yes TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:10679934;11262231;11335119 No 2a1, Lower confidence direct evidence Yimeng Yin Matt Weirauch Yes $#ENSG00000105717#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002 $#ENSP00000251203#ENSG00000105717#ENST00000251203#Homeodomain#PBC FALSE 1432 ENSG00000139515 PDX1 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR009057;IPR017970;IPR017995;IPR020479; 3651 pancreatic and duodenal homeobox 1 [Source:HGNC Symbol;Acc:HGNC:6107] 2H1K DBD not tested None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:14704343 Yes 1a1, Direct HQ evidence Arttu Jolma Pratyush Das Yes $#ENSG00000139515#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:17941991$#ENSG00000139515#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019 $#ENSP00000370421#ENSG00000139515#ENST00000381033#Homeodomain# FALSE 1433 ENSG00000165462 PHOX2A Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR009057;IPR017970; 401 paired like homeobox 2a [Source:HGNC Symbol;Acc:HGNC:691] None DBD Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:11034547 Yes 1a1, Direct HQ evidence Sam Lambert Laura Campitelli Yes $#ENSG00000165462#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:8661014 $#ENSP00000298231#ENSG00000165462#ENST00000298231#Homeodomain#$#ENSP00000444845#ENSG00000165462#ENST00000546310#Homeodomain# FALSE 1434 ENSG00000109132 PHOX2B Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR009057;IPR017970; 8929 paired like homeobox 2b [Source:HGNC Symbol;Acc:HGNC:9143] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:11752063;16280598 Yes 1a1, Direct HQ evidence Sam Lambert Arttu Jolma Yes $#ENSG00000109132#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:16144830 $#ENSP00000226382#ENSG00000109132#ENST00000226382#Homeodomain# FALSE 1435 ENSG00000069011 PITX1 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR003654;IPR009057;IPR016233;IPR017970;IPR020479 5307 paired like homeodomain 1 [Source:HGNC Symbol;Acc:HGNC:9004] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:11328855;15226417 Yes 1a1, Direct HQ evidence Laura Campitelli Arttu Jolma Yes $#ENSG00000069011#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000069011#GO:0003700#sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024 $#ENSP00000265340#ENSG00000069011#ENST00000265340#Homeodomain#OAR$#ENSP00000427542#ENSG00000069011#ENST00000506438#Homeodomain#OAR$#ENSP00000423624#ENSG00000069011#ENST00000502676#Homeodomain#$#ENSP00000451199#ENSG00000069011#ENST00000503586#Homeodomain#$#ENSP00000422908#ENSG00000069011#ENST00000507253#Homeodomain# FALSE 1436 ENSG00000164093 PITX2 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR003654;IPR009057;IPR016233;IPR017970;IPR020479 5308 paired like homeodomain 2 [Source:HGNC Symbol;Acc:HGNC:9005] 2LKX DBD and Full Yes None None a Yes TF Gene_Transcription Factor Binding: tf co-factor binding_DNA Binding; Transactivation_PMIDS:15728254 Yes 1a1, Direct HQ evidence Pratyush Das Arttu Jolma Yes $#ENSG00000164093#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000164093#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:15385555 $#ENSP00000304169#ENSG00000164093#ENST00000306732#Homeodomain#OAR$#ENSP00000347192#ENSG00000164093#ENST00000355080#Homeodomain#OAR$#ENSP00000378097#ENSG00000164093#ENST00000394598#Homeodomain#OAR$#ENSP00000347004#ENSG00000164093#ENST00000354925#Homeodomain#OAR$#ENSP00000475617#ENSG00000164093#ENST00000557119#Homeodomain#$#ENSP00000424142#ENSG00000164093#ENST00000511990#Homeodomain# FALSE 1437 ENSG00000107859 PITX3 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR003654;IPR009057;IPR016233;IPR017970; 5309 paired like homeodomain 3 [Source:HGNC Symbol;Acc:HGNC:9006] None DBD Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:11299318 No 1a1, Direct HQ evidence Yimeng Yin Tim Hughes Yes $#ENSG00000107859#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019 $#ENSP00000359019#ENSG00000107859#ENST00000370002#Homeodomain#OAR$#ENSP00000439383#ENSG00000107859#ENST00000539804#Homeodomain#OAR FALSE 1438 ENSG00000160199 PKNOX1 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR008422;IPR009057; 5316 PBX/knotted 1 homeobox 1 [Source:HGNC Symbol;Acc:HGNC:9022] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:9482739;10869353 Yes 1a1, Direct HQ evidence Matt Weirauch Arttu Jolma Yes $#ENSG00000160199#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IEA - GO_REF:0000019$#ENSG00000160199#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:9143494$#ENSG00000160199#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019 $#ENSP00000291547#ENSG00000160199#ENST00000291547#Homeodomain#Meis_PKNOX_N$#ENSP00000402243#ENSG00000160199#ENST00000432907#Homeodomain#Meis_PKNOX_N FALSE 1439 ENSG00000165495 PKNOX2 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR008422;IPR009057; 63876 PBX/knotted 1 homeobox 2 [Source:HGNC Symbol;Acc:HGNC:16714] None DBD Yes None None b Yes TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_Co-activation_PMIDS:11972344;15339927 No 1a1, Direct HQ evidence Matt Weirauch Pratyush Das Yes None $#ENSP00000298282#ENSG00000165495#ENST00000298282#Homeodomain#Meis_PKNOX_N$#ENSP00000431599#ENSG00000165495#ENST00000527238#Homeodomain#$#ENSP00000434255#ENSG00000165495#ENST00000531212#Homeodomain#$#ENSP00000453374#ENSG00000165495#ENST00000558705#Homeodomain# FALSE 1440 ENSG00000175325 PROP1 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000047;IPR001356;IPR009057;IPR017970 5626 PROP paired-like homeobox 1 [Source:HGNC Symbol;Acc:HGNC:9455] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_Transactivation_PMIDS:10199788;11064154 No 1a1, Direct HQ evidence Laura Campitelli Arttu Jolma Yes $#ENSG00000175325#GO:0001205#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involv#IEA - GO_REF:0000019$#ENSG00000175325#GO:0001206#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involv#IEA - GO_REF:0000019 $#ENSP00000311290#ENSG00000175325#ENST00000308304#Homeodomain# FALSE 1441 ENSG00000116132 PRRX1 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR003654;IPR009057;IPR017970 5396 paired related homeobox 1 [Source:HGNC Symbol;Acc:HGNC:9142] None DBD and Full Yes None None a Yes TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:9334314 No 1a1, Direct HQ evidence Sam Lambert Matt Weirauch Yes None $#ENSP00000239461#ENSG00000116132#ENST00000239461#Homeodomain#OAR$#ENSP00000356734#ENSG00000116132#ENST00000367760#Homeodomain#$#ENSP00000450762#ENSG00000116132#ENST00000497230#Homeodomain# FALSE 1442 ENSG00000167157 PRRX2 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR003654;IPR009057;IPR017970 51450 paired related homeobox 2 [Source:HGNC Symbol;Acc:HGNC:21338] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:7901837 Yes 1a1, Direct HQ evidence Jussi Taipale Pratyush Das Yes $#ENSG00000167157#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:11063257 $#ENSP00000361547#ENSG00000167157#ENST00000372469#Homeodomain#OAR FALSE 1443 ENSG00000134438 RAX Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR003654;IPR009057;IPR017970 30062 retina and anterior neural fold homeobox [Source:HGNC Symbol;Acc:HGNC:18662] None DBD Yes None None a Yes TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:11069920;10625658;10625658;10625658;10625658;11069920 Yes 1a1, Direct HQ evidence Matt Weirauch Tim Hughes Yes $#ENSG00000134438#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:10625658 $#ENSP00000256852#ENSG00000134438#ENST00000256852#Homeodomain#$#ENSP00000334813#ENSG00000134438#ENST00000334889#Homeodomain#OAR$#ENSP00000450583#ENSG00000134438#ENST00000555288#Homeodomain# FALSE 1444 ENSG00000173976 RAX2 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR009057;IPR017970; 84839 retina and anterior neural fold homeobox 2 [Source:HGNC Symbol;Acc:HGNC:18286] None DBD not tested None None b Yes No No 1a1, Direct HQ evidence Pratyush Das Arttu Jolma Yes None $#ENSP00000450456#ENSG00000173976#ENST00000555633#Homeodomain#$#ENSP00000450687#ENSG00000173976#ENST00000555978#Homeodomain# FALSE 1445 ENSG00000101883 RHOXF1 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000047;IPR001356;IPR009057;IPR017970 158800 Rhox homeobox family member 1 [Source:HGNC Symbol;Acc:HGNC:29993] None DBD and Full not tested None None b Yes No Yes 1a1, Direct HQ evidence Matt Weirauch Tim Hughes Yes $#ENSG00000101883#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:12490318 $#ENSP00000217999#ENSG00000101883#ENST00000217999#Homeodomain# FALSE 1446 ENSG00000131721 RHOXF2 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR009057;IPR017970; 84528 Rhox homeobox family member 2 [Source:HGNC Symbol;Acc:HGNC:30011] None DBD and Full not tested None None b Yes No No 1a1, Direct HQ evidence Tim Hughes Jussi Taipale Yes None $#ENSP00000360441#ENSG00000131721#ENST00000371388#Homeodomain# FALSE 1447 ENSG00000203989 RHOXF2B Homeodomain Yes Inferred motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR009057;IPR017970; 727940 Rhox homeobox family member 2B [Source:HGNC Symbol;Acc:HGNC:33519] None DBD Yes None None x Yes No No 4a, two or more datasets predict it as a TF Yimeng Yin Pratyush Das Yes None $#ENSP00000360455#ENSG00000203989#ENST00000371402#Homeodomain# FALSE 1448 ENSG00000274529 SEBOX Homeodomain Yes Inferred motif Monomer or homomultimer High-throughput in vitro None Role in early development (PMID: 24018616). IPR001356;IPR009057 645832 SEBOX homeobox [Source:HGNC Symbol;Acc:HGNC:32942] None DBD Yes None PMID:24018616 seems like a real homeobox with role in early development b Yes Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0 No 1a1, Direct HQ evidence Laura Campitelli Arttu Jolma Yes None $#ENSP00000444503#ENSG00000274529#ENST00000536498#Homeodomain# FALSE 1449 ENSG00000185960 SHOX Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000047;IPR001356;IPR003654;IPR009057;IPR017970; 6473 short stature homeobox [Source:HGNC Symbol;Acc:HGNC:10853] None DBD Yes None None a Yes No Yes 1a1, Direct HQ evidence Pratyush Das Laura Campitelli Yes $#ENSG00000185960#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:9259282 $#ENSP00000370987#ENSG00000185960#ENST00000381575#Homeodomain#$#ENSP00000452016#ENSG00000185960#ENST00000554971#Homeodomain#OAR$#ENSP00000335505#ENSG00000185960#ENST00000334060#Homeodomain#$#ENSP00000370990#ENSG00000185960#ENST00000381578#Homeodomain#OAR FALSE 1450 ENSG00000168779 SHOX2 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000047;IPR001356;IPR003654;IPR009057;IPR017970; 6474 short stature homeobox 2 [Source:HGNC Symbol;Acc:HGNC:10854] None DBD and Full Yes None None a Yes No No 1a1, Direct HQ evidence Pratyush Das Sam Lambert Yes None $#ENSP00000374240#ENSG00000168779#ENST00000389589#Homeodomain#OAR$#ENSP00000419362#ENSG00000168779#ENST00000483851#Homeodomain#OAR FALSE 1451 ENSG00000126778 SIX1 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR009057;IPR017970; 6495 SIX homeobox 1 [Source:HGNC Symbol;Acc:HGNC:10887] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:9826681 Yes 1a1, Direct HQ evidence Tim Hughes Arttu Jolma Yes $#ENSG00000126778#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:15141091 | IMP - PMID:15141091$#ENSG00000126778#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:19497856 | ISS - GO_REF:0000024 $#ENSP00000247182#ENSG00000126778#ENST00000247182#Homeodomain#SIX1_SD$#ENSP00000452700#ENSG00000126778#ENST00000554986#Homeodomain# FALSE 1452 ENSG00000170577 SIX2 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR009057;IPR017970; 10736 SIX homeobox 2 [Source:HGNC Symbol;Acc:HGNC:10888] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:15327782 Yes 1a1, Direct HQ evidence Yimeng Yin Jussi Taipale Yes $#ENSG00000170577#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000170577#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:10773454 $#ENSP00000304502#ENSG00000170577#ENST00000303077#Homeodomain#SIX1_SD FALSE 1453 ENSG00000138083 SIX3 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR009057 6496 SIX homeobox 3 [Source:HGNC Symbol;Acc:HGNC:10889] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_Co-activation_PMIDS:12543801 Yes 1a1, Direct HQ evidence Sam Lambert Yimeng Yin Yes $#ENSG00000138083#GO:0001205#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involv#IEA - GO_REF:0000019$#ENSG00000138083#GO:0003700#sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024 $#ENSP00000260653#ENSG00000138083#ENST00000260653#Homeodomain#SIX1_SD FALSE 1454 ENSG00000100625 SIX4 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR009057;IPR017970; 51804 SIX homeobox 4 [Source:HGNC Symbol;Acc:HGNC:10890] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:14966291 No 1a1, Direct HQ evidence Laura Campitelli Arttu Jolma Yes $#ENSG00000100625#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019 $#ENSP00000216513#ENSG00000100625#ENST00000216513#Homeodomain#SIX1_SD$#ENSP00000450761#ENSG00000100625#ENST00000556952#Homeodomain#SIX1_SD FALSE 1455 ENSG00000177045 SIX5 Homeodomain Yes Known motif Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain None IPR001356;IPR009057;IPR017970; 147912 SIX homeobox 5 [Source:HGNC Symbol;Acc:HGNC:10891] None DBD not tested None None a Yes No No 1a1, Direct HQ evidence Pratyush Das Jussi Taipale Yes None $#ENSP00000316842#ENSG00000177045#ENST00000317578#Homeodomain#SIX1_SD$#ENSP00000453239#ENSG00000177045#ENST00000560160#Homeodomain#SIX1_SD$#ENSP00000453189#ENSG00000177045#ENST00000560168#Homeodomain#$#ENSP00000481365#ENSG00000177045#ENST00000622857#Homeodomain# FALSE 1456 ENSG00000184302 SIX6 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR009057 4990 SIX homeobox 6 [Source:HGNC Symbol;Acc:HGNC:10892] None DBD Yes None None a Yes No No 1a1, Direct HQ evidence Sam Lambert Arttu Jolma Yes $#ENSG00000184302#GO:0001205#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involv#IEA - GO_REF:0000019 $#ENSP00000328596#ENSG00000184302#ENST00000327720#Homeodomain#SIX1_SD FALSE 1457 ENSG00000177426 TGIF1 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR008422;IPR009057; 7050 TGFB induced factor homeobox 1 [Source:HGNC Symbol;Acc:HGNC:11776] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:8537382 Yes 1a1, Direct HQ evidence Sam Lambert Laura Campitelli Yes $#ENSG00000177426#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:10764806 | IMP - PMID:10764806$#ENSG00000177426#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:8537382 $#ENSP00000327959#ENSG00000177426#ENST00000330513#Homeodomain#$#ENSP00000339631#ENSG00000177426#ENST00000343820#Homeodomain#$#ENSP00000385206#ENSG00000177426#ENST00000401449#Homeodomain#$#ENSP00000384970#ENSG00000177426#ENST00000405385#Homeodomain#$#ENSP00000449501#ENSG00000177426#ENST00000472042#Homeodomain#$#ENSP00000446944#ENSG00000177426#ENST00000551402#Homeodomain#$#ENSP00000450025#ENSG00000177426#ENST00000551541#Homeodomain#$#ENSP00000449287#ENSG00000177426#ENST00000552383#Homeodomain#$#ENSP00000483499#ENSG00000177426#ENST00000618001#Homeodomain#$#ENSP00000343969#ENSG00000177426#ENST00000345133#Homeodomain#$#ENSP00000383031#ENSG00000177426#ENST00000400167#Homeodomain#$#ENSP00000384133#ENSG00000177426#ENST00000407501#Homeodomain#$#ENSP00000448934#ENSG00000177426#ENST00000546979#Homeodomain#$#ENSP00000447747#ENSG00000177426#ENST00000548489#Homeodomain#$#ENSP00000449973#ENSG00000177426#ENST00000549253#Homeodomain#$#ENSP00000449722#ENSG00000177426#ENST00000549468#Homeodomain#$#ENSP00000449531#ENSG00000177426#ENST00000550958#Homeodomain#$#ENSP00000446838#ENSG00000177426#ENST00000551333#Homeodomain#$#ENSP00000462285#ENSG00000177426#ENST00000577543#Homeodomain# FALSE 1458 ENSG00000118707 TGIF2 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR008422;IPR009057; 60436 TGFB induced factor homeobox 2 [Source:HGNC Symbol;Acc:HGNC:15764] None DBD Yes None None x Yes No Yes 1a1, Direct HQ evidence Tim Hughes Laura Campitelli Yes $#ENSG00000118707#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:11006116 $#ENSP00000362979#ENSG00000118707#ENST00000373872#Homeodomain#$#ENSP00000362981#ENSG00000118707#ENST00000373874#Homeodomain#$#ENSP00000476174#ENSG00000118707#ENST00000557885#Homeodomain#$#ENSP00000452878#ENSG00000118707#ENST00000558028#Homeodomain#$#ENSP00000481787#ENSG00000118707#ENST00000611732#Homeodomain#$#ENSP00000475479#ENSG00000118707#ENST00000558465#Homeodomain#$#ENSP00000453773#ENSG00000118707#ENST00000560025#Homeodomain#$#ENSP00000475729#ENSG00000118707#ENST00000561398#Homeodomain#Homeobox_KN FALSE 1459 ENSG00000153779 TGIF2LX Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR008422;IPR009057; 90316 TGFB induced factor homeobox 2 like, X-linked [Source:HGNC Symbol;Acc:HGNC:18570] None DBD and Full not tested None None a Yes No No 1a1, Direct HQ evidence Pratyush Das Yimeng Yin Yes None $#ENSP00000355119#ENSG00000153779#ENST00000283891#Homeodomain#$#ENSP00000453704#ENSG00000153779#ENST00000561129#Homeodomain# FALSE 1460 ENSG00000176679 TGIF2LY Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR008422;IPR009057; 90655 TGFB induced factor homeobox 2 like, Y-linked [Source:HGNC Symbol;Acc:HGNC:18569] None DBD and Full not tested None None a Yes No No 1a1, Direct HQ evidence Pratyush Das Arttu Jolma Yes None $#ENSP00000318502#ENSG00000176679#ENST00000321217#Homeodomain#$#ENSP00000453750#ENSG00000176679#ENST00000559055#Homeodomain# FALSE 1461 ENSG00000107807 TLX1 Homeodomain Yes Known motif Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain None IPR001356;IPR009057;IPR017970;IPR020479 3195 T-cell leukemia homeobox 1 [Source:HGNC Symbol;Acc:HGNC:5056] None DBD and Full not tested None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:15944191 Yes 2a1, Lower confidence direct evidence Tim Hughes Jussi Taipale Yes None $#ENSP00000359215#ENSG00000107807#ENST00000370196#Homeodomain#$#ENSP00000434914#ENSG00000107807#ENST00000467928#Homeodomain#$#ENSP00000434358#ENSG00000107807#ENST00000463716#Homeodomain# FALSE 1462 ENSG00000115297 TLX2 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR009057;IPR017970;IPR020479 3196 T-cell leukemia homeobox 2 [Source:HGNC Symbol;Acc:HGNC:5057] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:10869550 No 1a1, Direct HQ evidence Pratyush Das Jussi Taipale Yes None $#ENSP00000233638#ENSG00000115297#ENST00000233638#Homeodomain#$#ENSP00000482690#ENSG00000115297#ENST00000621092#Homeodomain# FALSE 1463 ENSG00000164438 TLX3 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR009057;IPR017970;IPR020479 30012 T-cell leukemia homeobox 3 [Source:HGNC Symbol;Acc:HGNC:13532] None DBD and Full Yes None None a Yes Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0 No 1a1, Direct HQ evidence Pratyush Das Arttu Jolma Yes None $#ENSP00000296921#ENSG00000164438#ENST00000296921#Homeodomain# FALSE 1464 ENSG00000178928 TPRX1 Homeodomain Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Expressed in early embryo as transcripts that contain a full homeodomain (PMID: 27412763). IPR001356;IPR009057;IPR017970; 284355 tetra-peptide repeat homeobox 1 [Source:HGNC Symbol;Acc:HGNC:32174] None DBD and Full not tested None PMID:27412763 Expressed in early embryo as transcripts that contain a full homeodomain b Yes No No 3a, decent circumstantial evidence for its role as Sam Lambert Arttu Jolma Yes None $#ENSP00000323455#ENSG00000178928#ENST00000322175#Homeodomain#$#ENSP00000438832#ENSG00000178928#ENST00000535759#Homeodomain#$#ENSP00000438712#ENSG00000178928#ENST00000543508#Homeodomain# FALSE 1465 ENSG00000164853 UNCX Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR009057;IPR017970; 340260 UNC homeobox [Source:HGNC Symbol;Acc:HGNC:33194] None DBD not tested None None b Yes Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0 No 1a1, Direct HQ evidence Jussi Taipale Matt Weirauch Yes None $#ENSP00000314480#ENSG00000164853#ENST00000316333#Homeodomain# FALSE 1466 ENSG00000148704 VAX1 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000047;IPR001356;IPR009057;IPR017970 11023 ventral anterior homeobox 1 [Source:HGNC Symbol;Acc:HGNC:12660] None DBD Yes None None a Yes TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:15322073 Yes 1a1, Direct HQ evidence Laura Campitelli Yimeng Yin Yes $#ENSG00000148704#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IEA - GO_REF:0000019 $#ENSP00000277905#ENSG00000148704#ENST00000277905#Homeodomain#$#ENSP00000358207#ENSG00000148704#ENST00000369206#Homeodomain# FALSE 1467 ENSG00000116035 VAX2 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000047;IPR001356;IPR009057;IPR017970;IPR020479; 25806 ventral anterior homeobox 2 [Source:HGNC Symbol;Acc:HGNC:12661] None DBD and Full Yes None None a Yes Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0 Yes 1a1, Direct HQ evidence Yimeng Yin Laura Campitelli Yes $#ENSG00000116035#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IEA - GO_REF:0000019$#ENSG00000116035#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:10485894 $#ENSP00000234392#ENSG00000116035#ENST00000234392#Homeodomain# FALSE 1468 ENSG00000151650 VENTX Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR009057;IPR017970; 27287 VENT homeobox [Source:HGNC Symbol;Acc:HGNC:13639] None DBD and Full Yes None None b Yes No No 1a1, Direct HQ evidence Jussi Taipale Laura Campitelli Yes None $#ENSP00000357556#ENSG00000151650#ENST00000325980#Homeodomain# FALSE 1469 ENSG00000100987 VSX1 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR009057;IPR017970;IPR023339 30813 visual system homeobox 1 [Source:HGNC Symbol;Acc:HGNC:12723] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:11978762;15647262 Yes 1a1, Direct HQ evidence Sam Lambert Jussi Taipale Yes $#ENSG00000100987#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:10673340 $#ENSP00000365897#ENSG00000100987#ENST00000376707#Homeodomain#$#ENSP00000365899#ENSG00000100987#ENST00000376709#Homeodomain#$#ENSP00000401690#ENSG00000100987#ENST00000429762#Homeodomain#$#ENSP00000387720#ENSG00000100987#ENST00000444511#Homeodomain# FALSE 1470 ENSG00000119614 VSX2 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR003654;IPR009057;IPR017970;IPR023339; 338917 visual system homeobox 2 [Source:HGNC Symbol;Acc:HGNC:1975] None DBD and Full not tested None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:10903837;15647262 No 1a1, Direct HQ evidence Arttu Jolma Laura Campitelli Yes None $#ENSP00000261980#ENSG00000119614#ENST00000261980#Homeodomain#OAR FALSE 1471 ENSG00000136367 ZFHX2 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR003604;IPR007087;IPR009057;IPR015880;IPR017970 85446 zinc finger homeobox 2 [Source:HGNC Symbol;Acc:HGNC:20152] None not tested Yes None None b Yes No No 1a1, Direct HQ evidence Jussi Taipale Arttu Jolma Yes None $#ENSP00000409464#ENSG00000136367#ENST00000412565#Homeodomain#$#ENSP00000478696#ENSG00000136367#ENST00000615307#Homeodomain#$#ENSP00000413418#ENSG00000136367#ENST00000419474#Homeodomain#zf-C2H2_2, zf-H2C2_5, zf-met$#ENSP00000451342#ENSG00000136367#ENST00000555334#Homeodomain# FALSE 1472 ENSG00000165156 ZHX1 Homeodomain Yes Known motif Monomer or homomultimer High-throughput in vitro Has a putative AT-hook None IPR001356;IPR007087;IPR009057;IPR015880;IPR024578; 11244 zinc fingers and homeoboxes 1 [Source:HGNC Symbol;Acc:HGNC:12871] None DBD and Full Yes None None a Yes TF Gene Candidate_DNA-Binding: sequence-specific_Transactivation_PMIDS:12237128 Yes 1a1, Direct HQ evidence Laura Campitelli Arttu Jolma Yes $#ENSG00000165156#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:12237128 $#ENSP00000378938#ENSG00000165156#ENST00000395571#Homeodomain#$#ENSP00000428821#ENSG00000165156#ENST00000522655#Homeodomain#$#ENSP00000297857#ENSG00000165156#ENST00000297857#Homeodomain#$#ENSP00000475324#ENSG00000165156#ENST00000602651#Homeodomain# FALSE 1473 ENSG00000178764 ZHX2 Homeodomain Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR001356;IPR007087;IPR009057;IPR015880 22882 zinc fingers and homeoboxes 2 [Source:HGNC Symbol;Acc:HGNC:18513] None DBD and Full Yes None None a Yes TF Gene Candidate_DNA-Binding: sequence-specific_TF PPI; Transactivation_PMIDS:12741956;14659886 Yes 3a, decent circumstantial evidence for its role as Yimeng Yin Jussi Taipale Yes $#ENSG00000178764#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:12741956 $#ENSP00000314709#ENSG00000178764#ENST00000314393#Homeodomain#DUF3505, Homez$#ENSP00000452720#ENSG00000178764#ENST00000534247#Homeodomain# FALSE 1474 ENSG00000174306 ZHX3 Homeodomain Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR001356;IPR009057;IPR015880;IPR024578 23051 zinc fingers and homeoboxes 3 [Source:HGNC Symbol;Acc:HGNC:15935] None DBD and Full Yes None None a Yes No Yes 4a, two or more datasets predict it as a TF Yimeng Yin Jussi Taipale Yes $#ENSG00000174306#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:12659632 $#ENSP00000405421#ENSG00000174306#ENST00000421422#Homeodomain#$#ENSP00000443783#ENSG00000174306#ENST00000544979#Homeodomain#Homez$#ENSP00000452965#ENSG00000174306#ENST00000559234#Homeodomain#$#ENSP00000454006#ENSG00000174306#ENST00000560361#Homeodomain#$#ENSP00000362358#ENSG00000174306#ENST00000373261#Homeodomain#$#ENSP00000415498#ENSG00000174306#ENST00000432768#Homeodomain#$#ENSP00000401852#ENSG00000174306#ENST00000436099#Homeodomain#$#ENSP00000399433#ENSG00000174306#ENST00000441102#Homeodomain#zf-Di19$#ENSP00000453310#ENSG00000174306#ENST00000559436#Homeodomain#Homez$#ENSP00000403048#ENSG00000174306#ENST00000436440#Homeodomain# FALSE 1475 ENSG00000075891 PAX2 Homeodomain; Paired box Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001523;IPR009057;IPR022130; 5076 paired box 2 [Source:HGNC Symbol;Acc:HGNC:8616] None DBD not tested None None a Yes TF Gene_DNA-Binding: sequence-specific_Transactivation_PMIDS:11700324;11731455;14561758;12756174 No 1a1, Direct HQ evidence Matt Weirauch Laura Campitelli Yes None $#ENSP00000347385#ENSG00000075891#ENST00000355243#Homeodomain,Paired box#Pax2_C$#ENSP00000359319#ENSG00000075891#ENST00000370296#Homeodomain,Paired box#Pax2_C$#ENSP00000452489#ENSG00000075891#ENST00000554172#Homeodomain,Paired box#$#ENSP00000355069#ENSG00000075891#ENST00000361791#Homeodomain,Paired box#Pax2_C$#ENSP00000398652#ENSG00000075891#ENST00000427256#Homeodomain,Paired box# FALSE 1476 ENSG00000135903 PAX3 Homeodomain; Paired box Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR001523;IPR009057;IPR017970;IPR022106; 5077 paired box 3 [Source:HGNC Symbol;Acc:HGNC:8617] 3CMY DBD and Full not tested None None a Yes TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:16945326 Yes 1a1, Direct HQ evidence Yimeng Yin Arttu Jolma Yes $#ENSG00000135903#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002 $#ENSP00000258387#ENSG00000135903#ENST00000258387#Homeodomain,Paired box#$#ENSP00000338767#ENSG00000135903#ENST00000336840#Homeodomain,Paired box#Pax7$#ENSP00000342092#ENSG00000135903#ENST00000344493#Homeodomain,Paired box#Pax7$#ENSP00000375922#ENSG00000135903#ENST00000392070#Homeodomain,Paired box#Pax7$#ENSP00000386750#ENSG00000135903#ENST00000409551#Homeodomain,Paired box#Pax7$#ENSP00000386817#ENSG00000135903#ENST00000409828#Homeodomain,Paired box# FALSE 1477 ENSG00000106331 PAX4 Homeodomain; Paired box Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR001523;IPR009057;IPR017970 5078 paired box 4 [Source:HGNC Symbol;Acc:HGNC:8618] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:10567553 No 1a1, Direct HQ evidence Yimeng Yin Pratyush Das Yes $#ENSG00000106331#GO:0001206#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involv#IEA - GO_REF:0000019 $#ENSP00000339906#ENSG00000106331#ENST00000341640#Homeodomain,Paired box#$#ENSP00000368014#ENSG00000106331#ENST00000378740#Homeodomain,Paired box#$#ENSP00000451923#ENSG00000106331#ENST00000463946#Homeodomain,Paired box# FALSE 1478 ENSG00000007372 PAX6 Homeodomain; Paired box Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR001523;IPR009057;IPR017970 5080 paired box 6 [Source:HGNC Symbol;Acc:HGNC:8620] 6PAX DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_Transactivation_PMIDS:7753864;7841787;8132558;9710641;12756174 Yes 1a1, Direct HQ evidence Jussi Taipale Yimeng Yin Yes $#ENSG00000007372#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IDA - PMID:20592023$#ENSG00000007372#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000007372#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IEA - GO_REF:0000019$#ENSG00000007372#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:10441571, PMID:10747901 $#ENSP00000241001#ENSG00000007372#ENST00000241001#Homeodomain,Paired box#$#ENSP00000368406#ENSG00000007372#ENST00000379111#Homeodomain,Paired box#$#ENSP00000368410#ENSG00000007372#ENST00000379115#Homeodomain,Paired box#$#ENSP00000368418#ENSG00000007372#ENST00000379123#Homeodomain,Paired box#$#ENSP00000404100#ENSG00000007372#ENST00000419022#Homeodomain,Paired box#$#ENSP00000480026#ENSG00000007372#ENST00000606377#Homeodomain,Paired box#$#ENSP00000368403#ENSG00000007372#ENST00000379109#Homeodomain,Paired box#$#ENSP00000404356#ENSG00000007372#ENST00000438681#Homeodomain,Paired box#$#ENSP00000388132#ENSG00000007372#ENST00000423822#Homeodomain,Paired box#$#ENSP00000436365#ENSG00000007372#ENST00000525535#Homeodomain,Paired box# FALSE 1479 ENSG00000009709 PAX7 Homeodomain; Paired box Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001356;IPR001523;IPR009057;IPR017970;IPR022106; 5081 paired box 7 [Source:HGNC Symbol;Acc:HGNC:8621] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific; Transcription Regulatory Activity: heterochromatin interaction/binding_DNA Binding; Transactivation_PMIDS:15688409 Yes 1a1, Direct HQ evidence Laura Campitelli Yimeng Yin Yes $#ENSG00000009709#GO:0000983#RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019$#ENSG00000009709#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:9339373 $#ENSP00000364524#ENSG00000009709#ENST00000375375#Homeodomain,Paired box#Pax7$#ENSP00000383502#ENSG00000009709#ENST00000400661#Homeodomain,Paired box#Pax7$#ENSP00000403389#ENSG00000009709#ENST00000420770#Homeodomain,Paired box#Pax7 FALSE 1480 ENSG00000064835 POU1F1 Homeodomain; POU Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000327;IPR001356;IPR009057;IPR010982;IPR013847;IPR017970 5449 POU class 1 homeobox 1 [Source:HGNC Symbol;Acc:HGNC:9210] 1AU7 DBD Yes None None a Yes No Yes 1a1, Direct HQ evidence Arttu Jolma Yimeng Yin Yes $#ENSG00000064835#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IDA - PMID:26612202$#ENSG00000064835#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000064835#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:11301317, PMID:9482665 $#ENSP00000263781#ENSG00000064835#ENST00000350375#Homeodomain,POU#$#ENSP00000342931#ENSG00000064835#ENST00000344265#Homeodomain,POU#$#ENSP00000452610#ENSG00000064835#ENST00000560656#Homeodomain,POU#$#ENSP00000454072#ENSG00000064835#ENST00000561167#Homeodomain,POU# FALSE 1481 ENSG00000143190 POU2F1 Homeodomain; POU Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000327;IPR000972;IPR001356;IPR009057;IPR010982;IPR013847;IPR017970; 5451 POU class 2 homeobox 1 [Source:HGNC Symbol;Acc:HGNC:9212] 1E3O DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:1980478 Yes 1a1, Direct HQ evidence Laura Campitelli Sam Lambert Yes $#ENSG00000143190#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002 $#ENSP00000356836#ENSG00000143190#ENST00000367862#Homeodomain,POU#$#ENSP00000356840#ENSG00000143190#ENST00000367866#Homeodomain,POU#$#ENSP00000415993#ENSG00000143190#ENST00000443275#Homeodomain,POU#$#ENSP00000441285#ENSG00000143190#ENST00000541643#Homeodomain,POU#$#ENSP00000401217#ENSG00000143190#ENST00000429375#Homeodomain,POU# FALSE 1482 ENSG00000028277 POU2F2 Homeodomain; POU Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000327;IPR000972;IPR001356;IPR009057;IPR010982;IPR013847;IPR017970; 5452 POU class 2 homeobox 2 [Source:HGNC Symbol;Acc:HGNC:9213] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:2904653 Yes 1a1, Direct HQ evidence Sam Lambert Tim Hughes Yes $#ENSG00000028277#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000028277#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:9442393 $#ENSP00000373992#ENSG00000028277#ENST00000389341#Homeodomain,POU#$#ENSP00000431603#ENSG00000028277#ENST00000526816#Homeodomain,POU#$#ENSP00000437224#ENSG00000028277#ENST00000529067#Homeodomain,POU#$#ENSP00000436988#ENSG00000028277#ENST00000529952#Homeodomain,POU#$#ENSP00000490407#ENSG00000028277#ENST00000524801#Homeodomain,POU#DUF755$#ENSP00000476062#ENSG00000028277#ENST00000526831#Homeodomain,POU#AF-4$#ENSP00000475664#ENSG00000028277#ENST00000528894#Homeodomain,POU#$#ENSP00000490838#ENSG00000028277#ENST00000532176#Homeodomain,POU#$#ENSP00000453995#ENSG00000028277#ENST00000533548#Homeodomain,POU#$#ENSP00000471890#ENSG00000028277#ENST00000598842#Homeodomain,POU#$#ENSP00000490243#ENSG00000028277#ENST00000636631#Homeodomain,POU# FALSE 1483 ENSG00000137709 POU2F3 Homeodomain; POU Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000327;IPR000972;IPR001356;IPR009057;IPR010982;IPR013847;IPR017970; 25833 POU class 2 homeobox 3 [Source:HGNC Symbol;Acc:HGNC:19864] None DBD Yes None None a Yes No Yes 1a1, Direct HQ evidence Laura Campitelli Matt Weirauch Yes $#ENSG00000137709#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:12624109 | IMP - PMID:12624109 $#ENSP00000441687#ENSG00000137709#ENST00000543440#Homeodomain,POU#$#ENSP00000260264#ENSG00000137709#ENST00000260264#Homeodomain,POU#$#ENSP00000453150#ENSG00000137709#ENST00000532663#Homeodomain,POU# FALSE 1484 ENSG00000185668 POU3F1 Homeodomain; POU Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000327;IPR001356;IPR009057;IPR010982;IPR013847;IPR016362;IPR017970; 5453 POU class 3 homeobox 1 [Source:HGNC Symbol;Acc:HGNC:9214] 2XSD DBD Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:1705013;1979677 Yes 1a1, Direct HQ evidence Laura Campitelli Pratyush Das Yes $#ENSG00000185668#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002 $#ENSP00000362103#ENSG00000185668#ENST00000373012#Homeodomain,POU# FALSE 1485 ENSG00000184486 POU3F2 Homeodomain; POU Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000327;IPR001356;IPR009057;IPR010982;IPR013847;IPR016362;IPR017970; 5454 POU class 3 homeobox 2 [Source:HGNC Symbol;Acc:HGNC:9215] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:15262984 Yes 1a1, Direct HQ evidence Pratyush Das Arttu Jolma Yes $#ENSG00000184486#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000184486#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:7601453, PMID:9482665 $#ENSP00000329170#ENSG00000184486#ENST00000328345#Homeodomain,POU#DUF2722 FALSE 1486 ENSG00000198914 POU3F3 Homeodomain; POU Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000327;IPR001356;IPR009057;IPR010982;IPR013847;IPR016362;IPR017970; 5455 POU class 3 homeobox 3 [Source:HGNC Symbol;Acc:HGNC:9216] None DBD Yes None None a Yes No Yes 1a1, Direct HQ evidence Sam Lambert Arttu Jolma Yes $#ENSG00000198914#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002 $#ENSP00000355001#ENSG00000198914#ENST00000361360#Homeodomain,POU# FALSE 1487 ENSG00000196767 POU3F4 Homeodomain; POU Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000327;IPR001356;IPR009057;IPR010982;IPR013847;IPR016362;IPR017970; 5456 POU class 3 homeobox 4 [Source:HGNC Symbol;Acc:HGNC:9217] None DBD Yes None None a Yes No No 1a1, Direct HQ evidence Sam Lambert Pratyush Das Yes $#ENSG00000196767#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019 $#ENSP00000362296#ENSG00000196767#ENST00000373200#Homeodomain,POU# FALSE 1488 ENSG00000152192 POU4F1 Homeodomain; POU Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000327;IPR001356;IPR009057;IPR010982;IPR013847;IPR017970 5457 POU class 4 homeobox 1 [Source:HGNC Symbol;Acc:HGNC:9218] None DBD not tested None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:12810599 Yes 1a1, Direct HQ evidence Matt Weirauch Jussi Taipale Yes $#ENSG00000152192#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IDA - PMID:23805044$#ENSG00000152192#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000152192#GO:0001205#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involv#IEA - GO_REF:0000019$#ENSG00000152192#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024 $#ENSP00000366413#ENSG00000152192#ENST00000377208#Homeodomain,POU# FALSE 1489 ENSG00000151615 POU4F2 Homeodomain; POU Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000327;IPR001356;IPR009057;IPR010982;IPR013847;IPR017970 5458 POU class 4 homeobox 2 [Source:HGNC Symbol;Acc:HGNC:9219] None DBD and Full not tested None None a Yes No Yes 1a1, Direct HQ evidence Laura Campitelli Arttu Jolma Yes $#ENSG00000151615#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IDA - PMID:23805044$#ENSG00000151615#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:17637757, PMID:21241485$#ENSG00000151615#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#ISS - GO_REF:0000024 $#ENSP00000281321#ENSG00000151615#ENST00000281321#Homeodomain,POU# FALSE 1490 ENSG00000091010 POU4F3 Homeodomain; POU Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000327;IPR001356;IPR009057;IPR010982;IPR013847;IPR017970 5459 POU class 4 homeobox 3 [Source:HGNC Symbol;Acc:HGNC:9220] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:15465029 Yes 1a1, Direct HQ evidence Sam Lambert Jussi Taipale Yes $#ENSG00000091010#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:15465029$#ENSG00000091010#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IDA - PMID:23805044$#ENSG00000091010#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:9506947 $#ENSP00000230732#ENSG00000091010#ENST00000230732#Homeodomain,POU# FALSE 1491 ENSG00000204531 POU5F1 Homeodomain; POU Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000327;IPR001356;IPR009057;IPR010982;IPR013847;IPR017970 5460 POU class 5 homeobox 1 [Source:HGNC Symbol;Acc:HGNC:9221] 3L1P DBD and Full not tested None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:12615074 No 1a1, Direct HQ evidence Pratyush Das Arttu Jolma Yes $#ENSG00000204531#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#ISS - GO_REF:0000024$#ENSG00000204531#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IDA - PMID:19409607$#ENSG00000204531#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:16153702 $#ENSP00000259915#ENSG00000204531#ENST00000259915#Homeodomain,POU#$#ENSP00000389359#ENSG00000204531#ENST00000441888#Homeodomain,POU#$#ENSP00000425083#ENSG00000204531#ENST00000471529#Homeodomain,POU#$#ENSP00000425479#ENSG00000204531#ENST00000512818#Homeodomain,POU#$#ENSP00000475512#ENSG00000204531#ENST00000513407#Homeodomain,POU#$#ENSP00000475880#ENSG00000204531#ENST00000606567#Homeodomain,POU#$#ENSP00000484778#ENSG00000204531#ENST00000620031#Homeodomain,POU# FALSE 1492 ENSG00000212993 POU5F1B Homeodomain; POU Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000327;IPR001356;IPR009057;IPR010982;IPR013847;IPR017970 5462 POU class 5 homeobox 1B [Source:HGNC Symbol;Acc:HGNC:9223] None DBD not tested None Cell paper uses outdated symbol POU5F1P1, gene is not annotated as a pseudogene in the new version of Ensembl c Yes No Yes 1a1, Direct HQ evidence Pratyush Das Jussi Taipale Yes $#ENSG00000212993#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:1408763 $#ENSP00000419298#ENSG00000212993#ENST00000465342#Homeodomain,POU# FALSE 1493 ENSG00000248483 POU5F2 Homeodomain; POU Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR000327;IPR001356;IPR009057;IPR010982;IPR013847 134187 POU domain class 5, transcription factor 2 [Source:HGNC Symbol;Acc:HGNC:26367] None not tested not tested None Expressed in testis, contains both the POU and homeodomains No Yes No Yes 3a, decent circumstantial evidence for its role as Laura Campitelli Yimeng Yin Yes $#ENSG00000248483#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002 $#ENSP00000489796#ENSG00000248483#ENST00000606183#Homeodomain,POU# FALSE 1494 ENSG00000184271 POU6F1 Homeodomain; POU Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000327;IPR001356;IPR009057;IPR010982;IPR013847; 5463 POU class 6 homeobox 1 [Source:HGNC Symbol;Acc:HGNC:9224] 3D1N DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Other_PMIDS:8645295 Yes 1a1, Direct HQ evidence Jussi Taipale Arttu Jolma Yes $#ENSG00000184271#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002 $#ENSP00000330190#ENSG00000184271#ENST00000333640#Homeodomain,POU#$#ENSP00000448389#ENSG00000184271#ENST00000550824#Homeodomain,POU#$#ENSP00000373895#ENSG00000184271#ENST00000389243#Homeodomain,POU#$#ENSP00000490559#ENSG00000184271#ENST00000552305#Homeodomain,POU# FALSE 1495 ENSG00000106536 POU6F2 Homeodomain; POU Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000327;IPR001356;IPR009057;IPR010982;IPR013847; 11281 POU class 6 homeobox 2 [Source:HGNC Symbol;Acc:HGNC:21694] None DBD and Full not tested None None a Yes No Yes 1a1, Direct HQ evidence Arttu Jolma Tim Hughes Yes $#ENSG00000106536#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:8601806 $#ENSP00000430514#ENSG00000106536#ENST00000518318#Homeodomain,POU#$#ENSP00000409684#ENSG00000106536#ENST00000451021#Homeodomain,POU# FALSE 1496 ENSG00000185122 HSF1 HSF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000232;IPR010542 3297 heat shock transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:5224] 5D5U DBD and Full not tested None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:9545528 Yes 1a1, Direct HQ evidence Laura Campitelli Arttu Jolma Yes $#ENSG00000185122#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:8926278$#ENSG00000185122#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:10821850, PMID:1871105 $#ENSP00000431512#ENSG00000185122#ENST00000528838#HSF#Vert_HS_TF$#ENSP00000383590#ENSG00000185122#ENST00000400780#HSF#Vert_HS_TF$#ENSP00000436616#ENSG00000185122#ENST00000533240#HSF#HMMR_C, ZapB FALSE 1497 ENSG00000025156 HSF2 HSF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000232;IPR010542 3298 heat shock transcription factor 2 [Source:HGNC Symbol;Acc:HGNC:5225] 5D8K DBD and Full not tested None None a Yes No Yes 1a1, Direct HQ evidence Tim Hughes Laura Campitelli Yes $#ENSG00000025156#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IDA - PMID:10561509$#ENSG00000025156#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:1871106 $#ENSP00000357440#ENSG00000025156#ENST00000368455#HSF#Vert_HS_TF$#ENSP00000400380#ENSG00000025156#ENST00000452194#HSF#Vert_HS_TF$#ENSP00000477405#ENSG00000025156#ENST00000465214#HSF#Vert_HS_TF FALSE 1498 ENSG00000102878 HSF4 HSF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000232; 3299 heat shock transcription factor 4 [Source:HGNC Symbol;Acc:HGNC:5227] None DBD not tested None None a Yes TF Gene_DNA-Binding: sequence-specific; Transcription Factor Binding: tf co-factor binding_DNA Binding_PMIDS:8972228;10488131;11278480 Yes 1a1, Direct HQ evidence Yimeng Yin Tim Hughes Yes $#ENSG00000102878#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002 $#ENSP00000430947#ENSG00000102878#ENST00000521374#HSF#Vert_HS_TF$#ENSP00000463706#ENSG00000102878#ENST00000584272#HSF#$#ENSP00000428077#ENSG00000102878#ENST00000519601#HSF#$#ENSP00000429486#ENSG00000102878#ENST00000521916#HSF# FALSE 1499 ENSG00000176160 HSF5 HSF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000232; 124535 Heat shock transcription factor 5 [Source:HGNC Symbol;Acc:HGNC:26862] None DBD and Full not tested None None a Yes No No 1a1, Direct HQ evidence Pratyush Das Sam Lambert Yes $#ENSG00000176160#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002 $#ENSP00000313243#ENSG00000176160#ENST00000323777#HSF#$#ENSP00000484295#ENSG00000176160#ENST00000617946#HSF# FALSE 1500 ENSG00000171116 HSFX1 HSF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR000232; 100506164 heat shock transcription factor family, X-linked 1 [Source:HGNC Symbol;Acc:HGNC:29603] None DBD not tested None Y chromosome homolg binds DNA x Yes No No 3a, decent circumstantial evidence for its role as Jussi Taipale Pratyush Das Yes $#ENSG00000171116#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002 $#ENSP00000359444#ENSG00000171116#ENST00000370416#HSF# FALSE 1501 ENSG00000268738 HSFX2 HSF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR000232; 100130086 heat shock transcription factor family, X-linked 2 [Source:HGNC Symbol;Acc:HGNC:32701] None not tested not tested None Y chromosome homolg binds DNA x Yes No No 3a, decent circumstantial evidence for its role as Yimeng Yin Sam Lambert No None $#ENSP00000469223#ENSG00000268738#ENST00000598963#HSF# FALSE 1502 ENSG00000172468 HSFY1 HSF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000232; 159119 heat shock transcription factor, Y-linked 1 [Source:HGNC Symbol;Acc:HGNC:18568] None DBD and Full not tested None None a Yes No No 1a1, Direct HQ evidence Matt Weirauch Pratyush Das Yes $#ENSG00000172468#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002 $#ENSP00000303599#ENSG00000172468#ENST00000307393#HSF#$#ENSP00000311166#ENSG00000172468#ENST00000309834#HSF#$#ENSP00000372307#ENSG00000172468#ENST00000382856#HSF# FALSE 1503 ENSG00000169953 HSFY2 HSF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000232; 159119 heat shock transcription factor, Y-linked 2 [Source:HGNC Symbol;Acc:HGNC:23950] None DBD not tested None None a Yes No No 1a1, Direct HQ evidence Yimeng Yin Laura Campitelli No None $#ENSP00000306549#ENSG00000169953#ENST00000304790#HSF#$#ENSP00000340971#ENSG00000169953#ENST00000344884#HSF#$#ENSP00000372303#ENSG00000169953#ENST00000382852#HSF# FALSE 1504 ENSG00000125347 IRF1 IRF Yes Known motif Monomer or homomultimer In vivo/Misc source None None IPR001346;IPR017431;IPR019817; 3659 interferon regulatory factor 1 [Source:HGNC Symbol;Acc:HGNC:6116] 1IF1 DBD Yes None Requires phosphorylation for proper dimeric function; Jaspar model binds similar sites than the other homologs a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:3409321;12517966 Yes 1a1, Direct HQ evidence Laura Campitelli Arttu Jolma Yes $#ENSG00000125347#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IMP - PMID:15509808 $#ENSP00000245414#ENSG00000125347#ENST00000245414#Interferon regulatory factor (IRF)#$#ENSP00000480887#ENSG00000125347#ENST00000613424#Interferon regulatory factor (IRF)#$#ENSP00000473661#ENSG00000125347#ENST00000476613#Interferon regulatory factor (IRF)#$#ENSP00000405655#ENSG00000125347#ENST00000437654#Interferon regulatory factor (IRF)# FALSE 1505 ENSG00000168310 IRF2 IRF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001346;IPR017431;IPR019817; 3660 interferon regulatory factor 2 [Source:HGNC Symbol;Acc:HGNC:6117] 2IRF DBD and Full Yes None Requires phosphorylation for proper dimeric function a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:8798551;7687740 Yes 1a1, Direct HQ evidence Arttu Jolma Matt Weirauch Yes $#ENSG00000168310#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IMP - PMID:9540062$#ENSG00000168310#GO:0003700#sequence-specific DNA binding transcription factor activity#IMP - PMID:9540062 $#ENSP00000377218#ENSG00000168310#ENST00000393593#Interferon regulatory factor (IRF)#$#ENSP00000422860#ENSG00000168310#ENST00000506230#Interferon regulatory factor (IRF)#$#ENSP00000423074#ENSG00000168310#ENST00000502750#Interferon regulatory factor (IRF)#$#ENSP00000421927#ENSG00000168310#ENST00000505067#Interferon regulatory factor (IRF)# FALSE 1506 ENSG00000126456 IRF3 IRF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001346;IPR008984;IPR019471;IPR019817 3661 interferon regulatory factor 3 [Source:HGNC Symbol;Acc:HGNC:6118] 2O6G DBD and Full Yes None Requires phosphorylation for proper dimeric function a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:9660935 No 1a1, Direct HQ evidence Matt Weirauch Yimeng Yin Yes $#ENSG00000126456#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002 $#ENSP00000310127#ENSG00000126456#ENST00000309877#Interferon regulatory factor (IRF)#IRF-3$#ENSP00000366339#ENSG00000126456#ENST00000377135#Interferon regulatory factor (IRF)#IRF-3$#ENSP00000366344#ENSG00000126456#ENST00000377139#Interferon regulatory factor (IRF)#IRF-3$#ENSP00000400378#ENSG00000126456#ENST00000442265#Interferon regulatory factor (IRF)#$#ENSP00000472601#ENSG00000126456#ENST00000593922#Interferon regulatory factor (IRF)#IRF-3$#ENSP00000470512#ENSG00000126456#ENST00000596765#Interferon regulatory factor (IRF)#IRF-3$#ENSP00000470069#ENSG00000126456#ENST00000599144#Interferon regulatory factor (IRF)#IRF-3$#ENSP00000471358#ENSG00000126456#ENST00000599223#Interferon regulatory factor (IRF)#IRF-3$#ENSP00000472700#ENSG00000126456#ENST00000600022#Interferon regulatory factor (IRF)#IRF-3$#ENSP00000471896#ENSG00000126456#ENST00000601291#Interferon regulatory factor (IRF)#IRF-3$#ENSP00000471517#ENSG00000126456#ENST00000593818#Interferon regulatory factor (IRF)#IRF-3$#ENSP00000469113#ENSG00000126456#ENST00000597198#Interferon regulatory factor (IRF)#IRF-3$#ENSP00000471402#ENSG00000126456#ENST00000601373#Interferon regulatory factor (IRF)#IRF-3$#ENSP00000470140#ENSG00000126456#ENST00000601809#Interferon regulatory factor (IRF)#$#ENSP00000473176#ENSG00000126456#ENST00000593337#Interferon regulatory factor (IRF)#$#ENSP00000469067#ENSG00000126456#ENST00000595034#Interferon regulatory factor (IRF)#IRF-3$#ENSP00000468911#ENSG00000126456#ENST00000596822#Interferon regulatory factor (IRF)#$#ENSP00000472223#ENSG00000126456#ENST00000598108#Interferon regulatory factor (IRF)#IRF-3$#ENSP00000470905#ENSG00000126456#ENST00000600453#Interferon regulatory factor (IRF)# FALSE 1507 ENSG00000137265 IRF4 IRF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001346;IPR008984;IPR019471;IPR019817 3662 interferon regulatory factor 4 [Source:HGNC Symbol;Acc:HGNC:6119] None DBD and Full Yes None Requires phosphorylation for proper dimeric function a Yes No Yes 1a1, Direct HQ evidence Laura Campitelli Sam Lambert Yes $#ENSG00000137265#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:12374808$#ENSG00000137265#GO:0003700#sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024 | NAS - PMID:12374808 $#ENSP00000370343#ENSG00000137265#ENST00000380956#Interferon regulatory factor (IRF)#IRF-3, MH2 FALSE 1508 ENSG00000128604 IRF5 IRF Yes Known motif Monomer or homomultimer High-throughput in vitro Has a putative AT-hook None IPR001346;IPR008984;IPR019471;IPR019817 3663 interferon regulatory factor 5 [Source:HGNC Symbol;Acc:HGNC:6120] None DBD and Full Yes None Requires phosphorylation for proper dimeric function a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; TF PPI; Transactivation_PMIDS:12600985;15308637 No 1a1, Direct HQ evidence Sam Lambert Jussi Taipale Yes $#ENSG00000128604#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002 $#ENSP00000249375#ENSG00000128604#ENST00000249375#Interferon regulatory factor (IRF)#IRF-3$#ENSP00000349770#ENSG00000128604#ENST00000357234#Interferon regulatory factor (IRF)#IRF-3$#ENSP00000385352#ENSG00000128604#ENST00000402030#Interferon regulatory factor (IRF)#IRF-3$#ENSP00000419950#ENSG00000128604#ENST00000477535#Interferon regulatory factor (IRF)#IRF-3$#ENSP00000483292#ENSG00000128604#ENST00000619830#Interferon regulatory factor (IRF)# FALSE 1509 ENSG00000117595 IRF6 IRF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001346;IPR008984;IPR019471;IPR019817 3664 interferon regulatory factor 6 [Source:HGNC Symbol;Acc:HGNC:6121] None DBD and Full Yes None Requires phosphorylation for proper dimeric function a Yes No Yes 1a1, Direct HQ evidence Sam Lambert Matt Weirauch Yes $#ENSG00000117595#GO:0003700#sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024 $#ENSP00000355988#ENSG00000117595#ENST00000367021#Interferon regulatory factor (IRF)#IRF-3$#ENSP00000440532#ENSG00000117595#ENST00000542854#Interferon regulatory factor (IRF)#IRF-3$#ENSP00000403855#ENSG00000117595#ENST00000456314#Interferon regulatory factor (IRF)#IRF-3 FALSE 1510 ENSG00000185507 IRF7 IRF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001346;IPR008984;IPR019471;IPR019817 3665 interferon regulatory factor 7 [Source:HGNC Symbol;Acc:HGNC:6122] None DBD Yes None Requires phosphorylation for proper dimeric function a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:9786932 Yes 1a1, Direct HQ evidence Pratyush Das Yimeng Yin Yes $#ENSG00000185507#GO:0000982#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:17404045 $#ENSP00000331803#ENSG00000185507#ENST00000348655#Interferon regulatory factor (IRF)#IRF-3$#ENSP00000380697#ENSG00000185507#ENST00000397566#Interferon regulatory factor (IRF)#IRF-3$#ENSP00000380700#ENSG00000185507#ENST00000397570#Interferon regulatory factor (IRF)#IRF-3$#ENSP00000380704#ENSG00000185507#ENST00000397574#Interferon regulatory factor (IRF)#IRF-3 FALSE 1511 ENSG00000140968 IRF8 IRF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001346;IPR008984;IPR019471;IPR019817 3394 interferon regulatory factor 8 [Source:HGNC Symbol;Acc:HGNC:5358] None DBD and Full not tested None Requires phosphorylation for proper dimeric function a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:1460054;10734131 Yes 1a1, Direct HQ evidence Matt Weirauch Sam Lambert Yes $#ENSG00000140968#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#TAS - PMID:1460054 $#ENSP00000268638#ENSG00000140968#ENST00000268638#Interferon regulatory factor (IRF)#IRF-3, MH2$#ENSP00000458047#ENSG00000140968#ENST00000563180#Interferon regulatory factor (IRF)#$#ENSP00000456992#ENSG00000140968#ENST00000564803#Interferon regulatory factor (IRF)#IRF-3$#ENSP00000455452#ENSG00000140968#ENST00000562492#Interferon regulatory factor (IRF)#IRF-3, MH2$#ENSP00000455816#ENSG00000140968#ENST00000565552#Interferon regulatory factor (IRF)#$#ENSP00000455048#ENSG00000140968#ENST00000566369#Interferon regulatory factor (IRF)#$#ENSP00000455760#ENSG00000140968#ENST00000569145#Interferon regulatory factor (IRF)#$#ENSP00000456395#ENSG00000140968#ENST00000569607#Interferon regulatory factor (IRF)#IRF-3, MH2 FALSE 1512 ENSG00000213928 IRF9 IRF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001346;IPR008984;IPR019471;IPR019817 10379 interferon regulatory factor 9 [Source:HGNC Symbol;Acc:HGNC:6131] None DBD not tested None Requires phosphorylation for proper dimeric function a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:10497156;12574168 Yes 1a1, Direct HQ evidence Jussi Taipale Arttu Jolma Yes $#ENSG00000213928#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002 $#ENSP00000380073#ENSG00000213928#ENST00000396864#Interferon regulatory factor (IRF)#IRF-3 FALSE 1513 ENSG00000145220 LYAR LYAR-type C2H2 ZF No Unlikely to be sequence specific TF Not a DNA binding protein No motif None LYAR-type C2H2 ZF domains have not been shown to bind DNA. LYAR binds to the 60S subunit of the ribosome. It regulates translation rather than transcription (PMID: 24990247). None None Ly1 antibody reactive None not tested not tested None LYAR-type C2H2 ZF domains have not been shown to bind DNA. LYAR binds to the 60S subunit of the ribosome. It regulates translation rather than transcription (PMID: 24990247). No No No No Protein added after initial stage, no initial assesment Arttu Jolma Sam Lambert Yes None None FALSE 1514 ENSG00000188981 MSANTD1 MADF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None None 345222 Myb/SANT DNA binding domain containing 1 [Source:HGNC Symbol;Acc:HGNC:33741] None not tested not tested None None No Yes No No 5a, one of the source datasets predicts is as a TF Sam Lambert Pratyush Das No None $#ENSP00000423547#ENSG00000188981#ENST00000507492#MADF#$#ENSP00000411584#ENSG00000188981#ENST00000438480#MADF#$#ENSP00000420966#ENSG00000188981#ENST00000510580#MADF# FALSE 1515 ENSG00000066697 MSANTD3 MADF Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR028002; 91283 Myb/SANT DNA binding domain containing 3 [Source:HGNC Symbol;Acc:HGNC:23370] None not tested not tested None None No Yes No No 5a, one of the source datasets predicts is as a TF Yimeng Yin Laura Campitelli No None $#ENSP00000378506#ENSG00000066697#ENST00000395067#MADF#$#ENSP00000364020#ENSG00000066697#ENST00000374885#MADF#$#ENSP00000480445#ENSG00000066697#ENST00000613183#MADF#$#ENSP00000364021#ENSG00000066697#ENST00000374886#MADF#$#ENSP00000415830#ENSG00000066697#ENST00000398977#MADF#$#ENSP00000480622#ENSG00000066697#ENST00000622639#MADF# FALSE 1516 ENSG00000171169 NAIF1 MADF Yes Inferred motif Monomer or homomultimer High-throughput in vitro None None IPR028002; 203245 nuclear apoptosis inducing factor 1 [Source:HGNC Symbol;Acc:HGNC:25446] None not tested not tested None None No Yes No No 1a2, Orthologous HQ evidence Sam Lambert Matt Weirauch No None $#ENSP00000362170#ENSG00000171169#ENST00000373078#MADF# FALSE 1517 ENSG00000064489 BORCS8-MEF2B MADS box Yes Known motif Monomer or homomultimer 100 perc ID - in vitro None None IPR002100;IPR019320 4207 BORCS8-MEF2B readthrough [Source:HGNC Symbol;Acc:HGNC:39979] None DBD and Full not tested None None No Yes No No 1a2, Orthologous HQ evidence Laura Campitelli Matt Weirauch No None $#ENSP00000390762#ENSG00000064489#ENST00000444486#MADS box#$#ENSP00000454967#ENSG00000064489#ENST00000514819#MADS box# FALSE 1518 ENSG00000068305 MEF2A MADS box Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR002100;IPR022102 4205 Myocyte enhancer factor 2A [Source:HGNC Symbol;Acc:HGNC:6993] 1C7U DBD and Full not tested None None a Yes No No 1a1, Direct HQ evidence Tim Hughes Jussi Taipale Yes $#ENSG00000068305#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IDA - PMID:10748098, PMID:16484498, PMID:20590529$#ENSG00000068305#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:7760790$#ENSG00000068305#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:16043483$#ENSG00000068305#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019 $#ENSP00000346389#ENSG00000068305#ENST00000354410#MADS box#HJURP_C$#ENSP00000337202#ENSG00000068305#ENST00000338042#MADS box#HJURP_C$#ENSP00000454120#ENSG00000068305#ENST00000558812#MADS box#HJURP_C$#ENSP00000452989#ENSG00000068305#ENST00000559903#MADS box# FALSE 1519 ENSG00000213999 MEF2B MADS box Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR002100; 100271849 myocyte enhancer factor 2B [Source:HGNC Symbol;Acc:HGNC:6995] 1N6J DBD not tested None None a Yes No Yes 1a1, Direct HQ evidence Sam Lambert Laura Campitelli Yes $#ENSG00000213999#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:7760790$#ENSG00000213999#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:8575763 $#ENSP00000386480#ENSG00000213999#ENST00000409224#MADS box#$#ENSP00000386784#ENSG00000213999#ENST00000409447#MADS box#$#ENSP00000386374#ENSG00000213999#ENST00000410050#MADS box#$#ENSP00000402154#ENSG00000213999#ENST00000424583#MADS box# FALSE 1520 ENSG00000081189 MEF2C MADS box Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR002100;IPR022102 4208 myocyte enhancer factor 2C [Source:HGNC Symbol;Acc:HGNC:6996] None DBD and Full not tested None None a Yes No Yes 1a1, Direct HQ evidence Tim Hughes Matt Weirauch Yes $#ENSG00000081189#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#ISS - PMID:21610032$#ENSG00000081189#GO:0000983#RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity#IDA - PMID:8455629$#ENSG00000081189#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:15486975$#ENSG00000081189#GO:0001205#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involv#IEA - GO_REF:0000019$#ENSG00000081189#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:16043483 $#ENSP00000340874#ENSG00000081189#ENST00000340208#MADS box#HJURP_C$#ENSP00000389610#ENSG00000081189#ENST00000424173#MADS box#HJURP_C$#ENSP00000396219#ENSG00000081189#ENST00000437473#MADS box#HJURP_C$#ENSP00000421925#ENSG00000081189#ENST00000504921#MADS box#HJURP_C$#ENSP00000487184#ENSG00000081189#ENST00000626391#MADS box#HJURP_C$#ENSP00000487311#ENSG00000081189#ENST00000628656#MADS box#$#ENSP00000427163#ENSG00000081189#ENST00000502983#MADS box#HJURP_C$#ENSP00000424331#ENSG00000081189#ENST00000507984#MADS box#HJURP_C$#ENSP00000427309#ENSG00000081189#ENST00000509373#MADS box#$#ENSP00000490525#ENSG00000081189#ENST00000635898#MADS box#$#ENSP00000490473#ENSG00000081189#ENST00000636294#MADS box#HJURP_C$#ENSP00000489865#ENSG00000081189#ENST00000636541#MADS box#HJURP_C$#ENSP00000490630#ENSG00000081189#ENST00000636998#MADS box#HJURP_C$#ENSP00000490354#ENSG00000081189#ENST00000637481#MADS box#HJURP_C$#ENSP00000490241#ENSG00000081189#ENST00000637732#MADS box#HJURP_C FALSE 1521 ENSG00000116604 MEF2D MADS box Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR002100;IPR022102 4209 myocyte enhancer factor 2D [Source:HGNC Symbol;Acc:HGNC:6997] None DBD not tested None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:7760790;8269842 Yes 1a1, Direct HQ evidence Sam Lambert Arttu Jolma Yes $#ENSG00000116604#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IDA - PMID:20590529$#ENSG00000116604#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000116604#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:8575763 $#ENSP00000271555#ENSG00000116604#ENST00000348159#MADS box#HJURP_C$#ENSP00000353803#ENSG00000116604#ENST00000360595#MADS box#HJURP_C$#ENSP00000357223#ENSG00000116604#ENST00000368240#MADS box#HJURP_C FALSE 1522 ENSG00000112658 SRF MADS box Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR002100; 6722 serum response factor [Source:HGNC Symbol;Acc:HGNC:11291] 1SRS DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:11278806;15728583;16170155 Yes 1a1, Direct HQ evidence Yimeng Yin Jussi Taipale Yes $#ENSG00000112658#GO:0000983#RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity#IMP - PMID:18296735$#ENSG00000112658#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:20808827$#ENSG00000112658#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#ISS - GO_REF:0000024$#ENSG00000112658#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:3203386$#ENSG00000112658#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019$#ENSG00000112658#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:19098903 $#ENSP00000265354#ENSG00000112658#ENST00000265354#MADS box# FALSE 1523 ENSG00000123636 BAZ2B MBD Yes Likely to be sequence specific TF Low specificity DNA-binding protein No motif Has a putative AT-hook None IPR001487;IPR001739;IPR001965;IPR004022;IPR011011;IPR016177;IPR018359;IPR018500;IPR018501;IPR019787 29994 bromodomain adjacent to zinc finger domain 2B [Source:HGNC Symbol;Acc:HGNC:963] None not tested not tested None None x Yes No No 4a, two or more datasets predict it as a TF Jussi Taipale Pratyush Das No None $#ENSP00000376533#ENSG00000123636#ENST00000392782#Methyl-CpG DNA-binding#Bromodomain, DDT, Nop14, PHD, WSD$#ENSP00000400505#ENSG00000123636#ENST00000426648#Methyl-CpG DNA-binding#$#ENSP00000393565#ENSG00000123636#ENST00000441143#Methyl-CpG DNA-binding# FALSE 1524 ENSG00000134046 MBD2 MBD Yes Known motif Low specificity DNA-binding protein In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain; Has a putative AT-hook None IPR001739;IPR016177;IPR025884; 8932 methyl-CpG binding domain protein 2 [Source:HGNC Symbol;Acc:HGNC:6917] 2KY8 Full not tested None Structure has DNA with methylated CpG site x Yes TF Gene_Transcription Regulatory Activity: heterochromatin interaction/binding; DNA-Binding: non-sequence-specific_Non-specific DNA; Other_PMIDS:10471499;14610093 No 1a1, Direct HQ evidence Matt Weirauch Jussi Taipale No None $#ENSP00000256429#ENSG00000134046#ENST00000256429#Methyl-CpG DNA-binding#MBD_C$#ENSP00000464554#ENSG00000134046#ENST00000583046#Methyl-CpG DNA-binding#$#ENSP00000381435#ENSG00000134046#ENST00000398398#Methyl-CpG DNA-binding# FALSE 1525 ENSG00000071655 MBD3 MBD Yes Likely to be sequence specific TF Low specificity DNA-binding protein No motif None The MBD domain of MBD3 is thought to be primarily responsible for interaction with HDAC1 and MTA2, members of the NuRD complex (PMID: 12124384). More recently, studies have shown that it retains the ability to bind methylated CpG sites in vitro (PMID: 24307175) with lower affinity than other MBD proteins (e.g., MBD2), but does not distinguish between hydroxymethylated and unmethylated sites. Coupled with in vivo ChIP experiments, it appears that MBD3 binds unmethylated CpG sites in vivo after be IPR001739;IPR016177;IPR025884; 53615 methyl-CpG binding domain protein 3 [Source:HGNC Symbol;Acc:HGNC:6918] None not tested not tested None Binds methylated CpG dinucleotides x Yes No No 3a, decent circumstantial evidence for its role as Laura Campitelli Tim Hughes No None $#ENSP00000156825#ENSG00000071655#ENST00000156825#Methyl-CpG DNA-binding#MBD_C$#ENSP00000412302#ENSG00000071655#ENST00000434436#Methyl-CpG DNA-binding#MBD_C$#ENSP00000464718#ENSG00000071655#ENST00000590550#Methyl-CpG DNA-binding#MBD_C, MBDa, RasGAP FALSE 1526 ENSG00000129071 MBD4 MBD Yes Likely to be sequence specific TF Low specificity DNA-binding protein No motif None None IPR001739;IPR003265;IPR011257;IPR016177;IPR017352; 8930 methyl-CpG binding domain 4, DNA glycosylase [Source:HGNC Symbol;Acc:HGNC:6919] 2MOE not tested not tested None Structure has DNA with methylated CpG site x Yes No No 1a1, Direct HQ evidence Yimeng Yin Jussi Taipale No None $#ENSP00000249910#ENSG00000129071#ENST00000249910#Methyl-CpG DNA-binding#HhH-GPD$#ENSP00000376959#ENSG00000129071#ENST00000393278#Methyl-CpG DNA-binding#HhH-GPD$#ENSP00000394080#ENSG00000129071#ENST00000429544#Methyl-CpG DNA-binding#HhH-GPD$#ENSP00000424873#ENSG00000129071#ENST00000503197#Methyl-CpG DNA-binding#HhH-GPD$#ENSP00000422327#ENSG00000129071#ENST00000507208#Methyl-CpG DNA-binding#HhH-GPD FALSE 1527 ENSG00000166987 MBD6 MBD Yes Likely to be sequence specific TF Low specificity DNA-binding protein No motif None Has not been tested on PBM or HT-SELEX. Some evidence exists showing that it does not bind methylated DNA (PMID: 20700456), and the MBD domain instead facilitates protein interactions (PMID: 24634419). IPR001739;IPR016177 114785 methyl-CpG binding domain protein 6 [Source:HGNC Symbol;Acc:HGNC:20445] None not tested not tested None None No Yes No No 5a, one of the source datasets predicts is as a TF Yimeng Yin Matt Weirauch No None $#ENSP00000347896#ENSG00000166987#ENST00000355673#Methyl-CpG DNA-binding#$#ENSP00000448202#ENSG00000166987#ENST00000546632#Methyl-CpG DNA-binding#$#ENSP00000450160#ENSG00000166987#ENST00000552163#Methyl-CpG DNA-binding#$#ENSP00000446834#ENSG00000166987#ENST00000552659#Methyl-CpG DNA-binding# FALSE 1528 ENSG00000127445 PIN1 MBD Yes Likely to be sequence specific TF Low specificity DNA-binding protein No motif None None IPR000297;IPR001202;IPR023058 5300 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 [Source:HGNC Symbol;Acc:HGNC:8988] None not tested not tested None None No Yes TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:16227615 No 4a, two or more datasets predict it as a TF Yimeng Yin Matt Weirauch No None $#ENSP00000247970#ENSG00000127445#ENST00000247970#Methyl-CpG DNA-binding#Rotamase, Rotamase_2, Rotamase_3, WW$#ENSP00000466656#ENSG00000127445#ENST00000587625#Methyl-CpG DNA-binding#Rotamase, Rotamase_3, WW$#ENSP00000466962#ENSG00000127445#ENST00000588695#Methyl-CpG DNA-binding#Rotamase, Rotamase_2, Rotamase_3, WW FALSE 1529 ENSG00000143379 SETDB1 MBD Yes Known motif Low specificity DNA-binding protein In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain Transfac motif is dubious. IPR001214;IPR001739;IPR002999;IPR003606;IPR003616;IPR007728;IPR016177;IPR025796 9869 SET domain bifurcated 1 [Source:HGNC Symbol;Acc:HGNC:10761] None not tested not tested None None x Yes TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:14536086 No 2a1, Lower confidence direct evidence Jussi Taipale Sam Lambert No None $#ENSP00000271640#ENSG00000143379#ENST00000271640#Methyl-CpG DNA-binding#DUF4537, Pre-SET, SET$#ENSP00000357958#ENSG00000143379#ENST00000368962#Methyl-CpG DNA-binding#DUF4537$#ENSP00000357965#ENSG00000143379#ENST00000368969#Methyl-CpG DNA-binding#DUF4537, Pre-SET, SET$#ENSP00000436148#ENSG00000143379#ENST00000534805#Methyl-CpG DNA-binding#DUF4537$#ENSP00000432348#ENSG00000143379#ENST00000498193#Methyl-CpG DNA-binding#DUF4537, Pre-SET, SET$#ENSP00000407831#ENSG00000143379#ENST00000423081#Methyl-CpG DNA-binding# FALSE 1530 ENSG00000136169 SETDB2 MBD Yes Likely to be sequence specific TF Low specificity DNA-binding protein No motif None None IPR001214;IPR001739;IPR003606;IPR007728;IPR016177; 83852 SET domain bifurcated 2 [Source:HGNC Symbol;Acc:HGNC:20263] None not tested not tested None None x Yes No No 4a, two or more datasets predict it as a TF Laura Campitelli Matt Weirauch No None $#ENSP00000326477#ENSG00000136169#ENST00000317257#Methyl-CpG DNA-binding#Pre-SET, SET$#ENSP00000346175#ENSG00000136169#ENST00000354234#Methyl-CpG DNA-binding#Pre-SET, SET$#ENSP00000258672#ENSG00000136169#ENST00000258672#Methyl-CpG DNA-binding#Pre-SET, SET$#ENSP00000482240#ENSG00000136169#ENST00000611815#Methyl-CpG DNA-binding#Pre-SET, SET FALSE 1531 ENSG00000076108 BAZ2A MBD; AT hook Yes Likely to be sequence specific TF Low specificity DNA-binding protein No motif None Component of the silencing nucleolar remodelling complex (NoRC) (PMID: 22368283) IPR001487;IPR001739;IPR001965;IPR004022;IPR011011;IPR016177;IPR017956;IPR018359;IPR018500;IPR018501;IPR019787; 11176 bromodomain adjacent to zinc finger domain 2A [Source:HGNC Symbol;Acc:HGNC:962] None not tested not tested None None x Yes No No 4a, two or more datasets predict it as a TF Arttu Jolma Laura Campitelli No None $#ENSP00000368754#ENSG00000076108#ENST00000379441#Methyl-CpG DNA-binding#Bromodomain, DDT, PHD, WHIM1, WSD$#ENSP00000448760#ENSG00000076108#ENST00000549787#Methyl-CpG DNA-binding#Bromodomain, PHD, WSD$#ENSP00000446880#ENSG00000076108#ENST00000551812#Methyl-CpG DNA-binding#Bromodomain, DDT, PHD, WHIM1, WSD$#ENSP00000447248#ENSG00000076108#ENST00000549506#Methyl-CpG DNA-binding#$#ENSP00000447941#ENSG00000076108#ENST00000549884#Methyl-CpG DNA-binding#Bromodomain, DDT, PHD, WHIM1, WSD$#ENSP00000449496#ENSG00000076108#ENST00000546695#Methyl-CpG DNA-binding#$#ENSP00000449473#ENSG00000076108#ENST00000547650#Methyl-CpG DNA-binding# FALSE 1532 ENSG00000169057 MECP2 MBD; AT hook Yes Known motif Low specificity DNA-binding protein 100 perc ID - in vitro None Binds methylated CpG dinucleotides (PDB: 3C2I) IPR001739;IPR016177;IPR017353; 4204 methyl-CpG binding protein 2 [Source:HGNC Symbol;Acc:HGNC:6990] 3C2I not tested Yes None Binds methylated CpG dinucleotides x Yes TF Gene_Transcription Regulatory Activity: heterochromatin interaction/binding_Non-specific DNA_PMIDS:8177735;9038338 No 3a, decent circumstantial evidence for its role as Pratyush Das Arttu Jolma No $#ENSG00000169057#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019 $#ENSP00000301948#ENSG00000169057#ENST00000303391#Methyl-CpG DNA-binding#$#ENSP00000395535#ENSG00000169057#ENST00000453960#Methyl-CpG DNA-binding#$#ENSP00000486978#ENSG00000169057#ENST00000628176#Methyl-CpG DNA-binding#$#ENSP00000489847#ENSG00000169057#ENST00000637917#Methyl-CpG DNA-binding# FALSE 1533 ENSG00000141644 MBD1 MBD; CxxC ZF Yes Likely to be sequence specific TF Low specificity DNA-binding protein No motif None Binds CpG methylated DNA (PDB: 1IG4). It is unclear how much other specificity has been defined. IPR001739;IPR002857;IPR016177; 4152 methyl-CpG binding domain protein 1 [Source:HGNC Symbol;Acc:HGNC:6916] 1IG4 Full not tested None Structure has DNA with methylated CpG site x Yes TF Gene_Transcription Regulatory Activity: heterochromatin interaction/binding; DNA-Binding: non-sequence-specific_DNA Binding_PMIDS:15060159;15691849 No 1a1, Direct HQ evidence Jussi Taipale Arttu Jolma Yes None $#ENSP00000339546#ENSG00000141644#ENST00000339998#Methyl-CpG DNA-binding#$#ENSP00000285102#ENSG00000141644#ENST00000347968#Methyl-CpG DNA-binding#$#ENSP00000269469#ENSG00000141644#ENST00000353909#Methyl-CpG DNA-binding#$#ENSP00000381502#ENSG00000141644#ENST00000398488#Methyl-CpG DNA-binding#$#ENSP00000466092#ENSG00000141644#ENST00000585672#Methyl-CpG DNA-binding#$#ENSP00000467763#ENSG00000141644#ENST00000588937#Methyl-CpG DNA-binding#$#ENSP00000468785#ENSG00000141644#ENST00000590208#Methyl-CpG DNA-binding#$#ENSP00000465923#ENSG00000141644#ENST00000591535#Methyl-CpG DNA-binding#$#ENSP00000467606#ENSG00000141644#ENST00000592060#Methyl-CpG DNA-binding#$#ENSP00000372407#ENSG00000141644#ENST00000382948#Methyl-CpG DNA-binding#$#ENSP00000405268#ENSG00000141644#ENST00000457839#Methyl-CpG DNA-binding#$#ENSP00000468430#ENSG00000141644#ENST00000585595#Methyl-CpG DNA-binding#$#ENSP00000468042#ENSG00000141644#ENST00000587605#Methyl-CpG DNA-binding#$#ENSP00000466429#ENSG00000141644#ENST00000589733#Methyl-CpG DNA-binding#$#ENSP00000466806#ENSG00000141644#ENST00000589541#Methyl-CpG DNA-binding# FALSE 1534 ENSG00000127989 MTERF1 mTERF Yes Known motif Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain The structure (PDB: 3MVA) shows a large protein DNA-interaction interface. IPR003690 7978 mitochondrial transcription termination factor 1 [Source:HGNC Symbol;Acc:HGNC:21463] 3MVA not tested not tested None Structure has really big protein DNA-interaction interface No Yes No No 1a1, Direct HQ evidence Laura Campitelli Arttu Jolma No None $#ENSP00000248643#ENSG00000127989#ENST00000351870#mTERF#$#ENSP00000414116#ENSG00000127989#ENST00000419292#mTERF#$#ENSP00000400966#ENSG00000127989#ENST00000425936#mTERF#$#ENSP00000384986#ENSG00000127989#ENST00000406735#mTERF# FALSE 1535 ENSG00000120832 MTERF2 mTERF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR003690; 80298 mitochondrial transcription termination factor 2 [Source:HGNC Symbol;Acc:HGNC:30779] None not tested not tested None None No Yes No No 5a, one of the source datasets predicts is as a TF Tim Hughes Pratyush Das No None $#ENSP00000240050#ENSG00000120832#ENST00000240050#mTERF#$#ENSP00000376575#ENSG00000120832#ENST00000392830#mTERF#$#ENSP00000447651#ENSG00000120832#ENST00000552029#mTERF#$#ENSP00000448343#ENSG00000120832#ENST00000548101#mTERF#$#ENSP00000448246#ENSG00000120832#ENST00000550496#mTERF#$#ENSP00000448854#ENSG00000120832#ENST00000550736#mTERF# FALSE 1536 ENSG00000156469 MTERF3 mTERF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Crystral structure available (PMID: 20430012) IPR003690; 51001 mitochondrial transcription termination factor 3 [Source:HGNC Symbol;Acc:HGNC:24258] None not tested not tested None None No Yes No No 5a, one of the source datasets predicts is as a TF Jussi Taipale Matt Weirauch No None $#ENSP00000287025#ENSG00000156469#ENST00000287025#mTERF#Pex14_N$#ENSP00000429400#ENSG00000156469#ENST00000523821#mTERF#Pex14_N$#ENSP00000430138#ENSG00000156469#ENST00000522822#mTERF#$#ENSP00000429526#ENSG00000156469#ENST00000517720#mTERF#$#ENSP00000429267#ENSG00000156469#ENST00000524341#mTERF# FALSE 1537 ENSG00000122085 MTERF4 mTERF Yes Likely to be sequence specific TF Monomer or homomultimer No motif None MTERF4 can bind RNA (PMID: 22949673), but likely to also bind DNA like other mTERF family members. IPR003690;IPR016024 130916 mitochondrial transcription termination factor 4 [Source:HGNC Symbol;Acc:HGNC:28785] None not tested not tested None None No Yes No No 5a, one of the source datasets predicts is as a TF Matt Weirauch Sam Lambert No None $#ENSP00000375840#ENSG00000122085#ENST00000391980#mTERF#$#ENSP00000480378#ENSG00000122085#ENST00000614476#mTERF#$#ENSP00000384998#ENSG00000122085#ENST00000406593#mTERF#$#ENSP00000385630#ENSG00000122085#ENST00000407095#mTERF#$#ENSP00000413346#ENSG00000122085#ENST00000449133#mTERF#$#ENSP00000414989#ENSG00000122085#ENST00000439144#mTERF# FALSE 1538 ENSG00000183091 NEB mTERF No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Gene Cards/GO indicates that NEB is not present in the nucleus; and it appears to be an actin binding protein highly expressed in muscle. IPR000900;IPR001452;IPR013998 4703 nebulin [Source:HGNC Symbol;Acc:HGNC:7720] None not tested not tested None None No Yes No No 5a, one of the source datasets predicts is as a TF Jussi Taipale Sam Lambert No None $#ENSP00000172853#ENSG00000183091#ENST00000172853#mTERF#NFRKB_winged, Nebulin, Peptidase_M24, SH3_1, SH3_2$#ENSP00000410961#ENSG00000183091#ENST00000413693#mTERF#Nebulin, SH3_1, SH3_2, SH3_9$#ENSP00000404876#ENSG00000183091#ENST00000424585#mTERF#Nebulin FALSE 1539 ENSG00000258315 C17orf49 Myb/SANT No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Contains 1 SANT domain, suggesting it cannot bind DNA specifically IPR009057; 124944 chromosome 17 open reading frame 49 [Source:HGNC Symbol;Acc:HGNC:28737] None Full not tested None None x Yes No No 4a, two or more datasets predict it as a TF Laura Campitelli Arttu Jolma No None $#ENSP00000411851#ENSG00000258315#ENST00000439424#Myb, Myb-Like, and SANT Domain Containing Genes#$#ENSP00000448598#ENSG00000258315#ENST00000546495#Myb, Myb-Like, and SANT Domain Containing Genes#$#ENSP00000448746#ENSG00000258315#ENST00000552402#Myb, Myb-Like, and SANT Domain Containing Genes# FALSE 1540 ENSG00000096401 CDC5L Myb/SANT Yes Known motif Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain Compelling evidence for DNA binding (PMID: 11082045). IPR001005;IPR009057;IPR017930;IPR021786 988 cell division cycle 5 like [Source:HGNC Symbol;Acc:HGNC:1743] None DBD and Full not tested None None a Yes TF Evidence Conflict - There is evidence for and against this genes role as a TF___PMIDS:0;8917598;9038199;10570151;11082045;8917598;9038199;10570151;11118137 Yes 2a1, Lower confidence direct evidence Laura Campitelli Matt Weirauch Yes $#ENSG00000096401#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000360532#ENSG00000096401#ENST00000371477#Myb, Myb-Like, and SANT Domain Containing Genes#Myb_Cef FALSE 1541 ENSG00000173575 CHD2 Myb/SANT No Unlikely to be sequence specific TF Not a DNA binding protein No motif Only known motifs are from Transfac or HocoMoco - origin is uncertain; Has a putative AT-hook Although CHD2 has weak similarity to a Myb domain (PMID: 9326634), its more closely related to the non-DNA-binding SANT domain based on the alignment analysis. The data showing that show that CHD2 binding histone H3.3 (PMID:22569126) further support the conclusion that the Myb domain is probably a SANT domain facilitating the histone interaction IPR000330;IPR000953;IPR001650;IPR014001;IPR016197;IPR023779;IPR023780;IPR025260;IPR027417; 100422995 chromodomain helicase DNA binding protein 2 [Source:HGNC Symbol;Acc:HGNC:1917] None not tested not tested None None x Yes No No 2a1, Lower confidence direct evidence Sam Lambert Pratyush Das No None $#ENSP00000406581#ENSG00000173575#ENST00000420239#Myb, Myb-Like, and SANT Domain Containing Genes#Chromo$#ENSP00000486417#ENSG00000173575#ENST00000625243#Myb, Myb-Like, and SANT Domain Containing Genes#Chromo$#ENSP00000486391#ENSG00000173575#ENST00000625463#Myb, Myb-Like, and SANT Domain Containing Genes#Helicase_C$#ENSP00000486629#ENSG00000173575#ENST00000626874#Myb, Myb-Like, and SANT Domain Containing Genes#CHDCT2, Chromo, DUF4208, Helicase_C, ResIII, SNF2_$#ENSP00000486487#ENSG00000173575#ENST00000626782#Myb, Myb-Like, and SANT Domain Containing Genes#Chromo$#ENSP00000486926#ENSG00000173575#ENST00000627622#Myb, Myb-Like, and SANT Domain Containing Genes#$#ENSP00000489976#ENSG00000173575#ENST00000637613#Myb, Myb-Like, and SANT Domain Containing Genes#Chromo FALSE 1542 ENSG00000007545 CRAMP1 Myb/SANT No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Contains a single SANT domain, no evidence for sequence-specific DNA binding IPR001005;IPR017884 57585 cramped chromatin regulator homolog 1 [Source:HGNC Symbol;Acc:HGNC:14122] None Full not tested None None c No No No 5a, one of the source datasets predicts is as a TF Arttu Jolma Yimeng Yin Yes None $#ENSP00000399172#ENSG00000007545#ENST00000415022#Myb, Myb-Like, and SANT Domain Containing Genes#$#ENSP00000293925#ENSG00000007545#ENST00000293925#Myb, Myb-Like, and SANT Domain Containing Genes#Myb_DNA-bind_7$#ENSP00000380559#ENSG00000007545#ENST00000397412#Myb, Myb-Like, and SANT Domain Containing Genes#Myb_DNA-bind_7 FALSE 1543 ENSG00000135164 DMTF1 Myb/SANT Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Contains 2 Myb DBDs. Binds to CCCG(G/T)ATGT (PMID: 8887674) IPR001005;IPR009057;IPR017877;IPR017930 9988 cyclin D binding myb like transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:14603] None DBD and Full not tested None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:8425553;9786929 Yes 3a, decent circumstantial evidence for its role as Pratyush Das Arttu Jolma Yes $#ENSG00000135164#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000135164#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:10095122 $#ENSP00000332171#ENSG00000135164#ENST00000331242#Myb, Myb-Like, and SANT Domain Containing Genes#$#ENSP00000378193#ENSG00000135164#ENST00000394703#Myb, Myb-Like, and SANT Domain Containing Genes#$#ENSP00000416499#ENSG00000135164#ENST00000425705#Myb, Myb-Like, and SANT Domain Containing Genes#$#ENSP00000412532#ENSG00000135164#ENST00000432937#Myb, Myb-Like, and SANT Domain Containing Genes#$#ENSP00000463239#ENSG00000135164#ENST00000582204#Myb, Myb-Like, and SANT Domain Containing Genes#$#ENSP00000410288#ENSG00000135164#ENST00000454008#Myb, Myb-Like, and SANT Domain Containing Genes#$#ENSP00000461920#ENSG00000135164#ENST00000582925#Myb, Myb-Like, and SANT Domain Containing Genes# FALSE 1544 ENSG00000136770 DNAJC1 Myb/SANT No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Contains 2 SANT domains, and no other putative DNA-binding domains IPR001005;IPR001623;IPR009057;IPR017884;IPR018253; 64215 DnaJ heat shock protein family (Hsp40) member C1 [Source:HGNC Symbol;Acc:HGNC:20090] None not tested not tested None None x Yes No No 4a, two or more datasets predict it as a TF Pratyush Das Yimeng Yin Yes None $#ENSP00000366179#ENSG00000136770#ENST00000376980#Myb, Myb-Like, and SANT Domain Containing Genes#DnaJ FALSE 1545 ENSG00000105821 DNAJC2 Myb/SANT No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Contains 2 SANT domains, and no other putative DNA-binding domains IPR001005;IPR001623;IPR009057;IPR017884;IPR018253; 27000 DnaJ heat shock protein family (Hsp40) member C2 [Source:HGNC Symbol;Acc:HGNC:13192] None Full not tested None None c Yes No No 4a, two or more datasets predict it as a TF Yimeng Yin Sam Lambert Yes None $#ENSP00000249270#ENSG00000105821#ENST00000249270#Myb, Myb-Like, and SANT Domain Containing Genes#DnaJ$#ENSP00000368565#ENSG00000105821#ENST00000379263#Myb, Myb-Like, and SANT Domain Containing Genes#DnaJ, RAC_head$#ENSP00000406275#ENSG00000105821#ENST00000412522#Myb, Myb-Like, and SANT Domain Containing Genes# FALSE 1546 ENSG00000156030 ELMSAN1 Myb/SANT No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Contains a single SANT domain, no evidence for sequence-specific DNA binding IPR000949;IPR001005;IPR009057;IPR017884 91748 ELM2 and Myb/SANT domain containing 1 [Source:HGNC Symbol;Acc:HGNC:19853] None DBD not tested None None b Yes No Yes 4a, two or more datasets predict it as a TF Yimeng Yin Jussi Taipale Yes $#ENSG00000156030#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000286523#ENSG00000156030#ENST00000286523#Myb, Myb-Like, and SANT Domain Containing Genes#ELM2$#ENSP00000377634#ENSG00000156030#ENST00000394071#Myb, Myb-Like, and SANT Domain Containing Genes#ELM2$#ENSP00000402380#ENSG00000156030#ENST00000435371#Myb, Myb-Like, and SANT Domain Containing Genes#ELM2$#ENSP00000407767#ENSG00000156030#ENST00000423556#Myb, Myb-Like, and SANT Domain Containing Genes#ELM2 FALSE 1547 ENSG00000162929 KIAA1841 Myb/SANT No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Domain is truncated, and there is nothing known about this gene IPR021777; 84542 KIAA1841 [Source:HGNC Symbol;Acc:HGNC:29387] None not tested Yes None None No Yes No No 5a, one of the source datasets predicts is as a TF Jussi Taipale Laura Campitelli No None $#ENSP00000295031#ENSG00000162929#ENST00000295031#Myb, Myb-Like, and SANT Domain Containing Genes#DUF3342$#ENSP00000385579#ENSG00000162929#ENST00000402291#Myb, Myb-Like, and SANT Domain Containing Genes#DUF3342$#ENSP00000416795#ENSG00000162929#ENST00000453873#Myb, Myb-Like, and SANT Domain Containing Genes#DUF3342$#ENSP00000482126#ENSG00000162929#ENST00000612149#Myb, Myb-Like, and SANT Domain Containing Genes#DUF3342 FALSE 1548 ENSG00000198160 MIER1 Myb/SANT No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Contains a single SANT domain, no evidence for sequence-specific DNA binding IPR000949;IPR001005;IPR009057;IPR017884 57708 MIER1 transcriptional regulator [Source:HGNC Symbol;Acc:HGNC:29657] None DBD and Full Yes None None a Yes No No 4a, two or more datasets predict it as a TF Sam Lambert Pratyush Das Yes None $#ENSP00000347514#ENSG00000198160#ENST00000355356#Myb, Myb-Like, and SANT Domain Containing Genes#ELM2$#ENSP00000350321#ENSG00000198160#ENST00000357692#Myb, Myb-Like, and SANT Domain Containing Genes#ELM2$#ENSP00000360055#ENSG00000198160#ENST00000371016#Myb, Myb-Like, and SANT Domain Containing Genes#ELM2$#ENSP00000360057#ENSG00000198160#ENST00000371018#Myb, Myb-Like, and SANT Domain Containing Genes#ELM2$#ENSP00000383821#ENSG00000198160#ENST00000401042#Myb, Myb-Like, and SANT Domain Containing Genes#ELM2$#ENSP00000360051#ENSG00000198160#ENST00000371012#Myb, Myb-Like, and SANT Domain Containing Genes#$#ENSP00000360053#ENSG00000198160#ENST00000371014#Myb, Myb-Like, and SANT Domain Containing Genes#ELM2$#ENSP00000383820#ENSG00000198160#ENST00000401041#Myb, Myb-Like, and SANT Domain Containing Genes#ELM2 FALSE 1549 ENSG00000105556 MIER2 Myb/SANT No Unlikely to be sequence specific TF Not a DNA binding protein No motif Has a putative AT-hook MIER2s Myb domain is more similar to the non-DNA-binding SANT domain IPR000949;IPR001005;IPR009057;IPR017884 54531 MIER family member 2 [Source:HGNC Symbol;Acc:HGNC:29210] None not tested not tested None None x Yes No No 4a, two or more datasets predict it as a TF Laura Campitelli Arttu Jolma Yes None $#ENSP00000264819#ENSG00000105556#ENST00000264819#Myb, Myb-Like, and SANT Domain Containing Genes#ELM2$#ENSP00000482489#ENSG00000105556#ENST00000619835#Myb, Myb-Like, and SANT Domain Containing Genes# FALSE 1550 ENSG00000155545 MIER3 Myb/SANT No Unlikely to be sequence specific TF Not a DNA binding protein No motif None MIER3s Myb domain is more similar to the non-DNA-binding SANT domain. Tested on both PBM and HT-SELEX, with no motif. IPR000949;IPR001005;IPR009057;IPR017884 166968 MIER family member 3 [Source:HGNC Symbol;Acc:HGNC:26678] None DBD and Full Yes None None b Yes No No 4a, two or more datasets predict it as a TF Pratyush Das Matt Weirauch Yes None $#ENSP00000370596#ENSG00000155545#ENST00000381199#Myb, Myb-Like, and SANT Domain Containing Genes#ELM2$#ENSP00000370611#ENSG00000155545#ENST00000381213#Myb, Myb-Like, and SANT Domain Containing Genes#ELM2$#ENSP00000370624#ENSG00000155545#ENST00000381226#Myb, Myb-Like, and SANT Domain Containing Genes#ELM2$#ENSP00000386584#ENSG00000155545#ENST00000409421#Myb, Myb-Like, and SANT Domain Containing Genes#ELM2 FALSE 1551 ENSG00000129534 MIS18BP1 Myb/SANT No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Contains 1 SANT domain, and a SANTA domain IPR001005;IPR009057;IPR015216;IPR017884 55320 MIS18 binding protein 1 [Source:HGNC Symbol;Acc:HGNC:20190] None Full not tested None None c Yes No No 4a, two or more datasets predict it as a TF Pratyush Das Laura Campitelli No None $#ENSP00000309790#ENSG00000129534#ENST00000310806#Myb, Myb-Like, and SANT Domain Containing Genes#SANTA$#ENSP00000397184#ENSG00000129534#ENST00000451174#Myb, Myb-Like, and SANT Domain Containing Genes#$#ENSP00000487102#ENSG00000129534#ENST00000627697#Myb, Myb-Like, and SANT Domain Containing Genes#SANTA FALSE 1552 ENSG00000170903 MSANTD4 Myb/SANT Yes Likely to be sequence specific TF Low specificity DNA-binding protein No motif None Contains a single Myb-like domain with an insertion in the middle. It is ambiguous whether Myb-like domains are DNA or protein binding. Since it has a single domain its likely non-specific. IPR028002 84437 Myb/SANT DNA binding domain containing 4 with coiled-coils [Source:HGNC Symbol;Acc:HGNC:29383] None not tested not tested None None No Yes No No 5a, one of the source datasets predicts is as a TF Yimeng Yin Laura Campitelli No None $#ENSP00000304713#ENSG00000170903#ENST00000301919#Myb, Myb-Like, and SANT Domain Containing Genes#Myb_DNA-bind_5$#ENSP00000435125#ENSG00000170903#ENST00000530788#Myb, Myb-Like, and SANT Domain Containing Genes#Myb_DNA-bind_5$#ENSP00000435372#ENSG00000170903#ENST00000530108#Myb, Myb-Like, and SANT Domain Containing Genes#Myb_DNA-bind_5$#ENSP00000432245#ENSG00000170903#ENST00000534458#Myb, Myb-Like, and SANT Domain Containing Genes# FALSE 1553 ENSG00000118513 MYB Myb/SANT Yes Known motif Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain Contains 3 Myb DBDs IPR001005;IPR009057;IPR012642;IPR015395;IPR017877;IPR017930 4602 MYB proto-oncogene, transcription factor [Source:HGNC Symbol;Acc:HGNC:7545] 1MSE DBD and Full Yes None None a Yes TF Gene Candidate_DNA-Binding: sequence-specific_DNA Binding_PMIDS:12244173;15691758 Yes 1a1, Direct HQ evidence Yimeng Yin Laura Campitelli Yes $#ENSG00000118513#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000118513#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IC - GO_REF:0000036 $#ENSP00000339992#ENSG00000118513#ENST00000341911#Myb, Myb-Like, and SANT Domain Containing Genes#Cmyb_C, LMSTEN$#ENSP00000356788#ENSG00000118513#ENST00000367814#Myb, Myb-Like, and SANT Domain Containing Genes#Cmyb_C, LMSTEN$#ENSP00000410825#ENSG00000118513#ENST00000442647#Myb, Myb-Like, and SANT Domain Containing Genes#Cmyb_C, LMSTEN$#ENSP00000435938#ENSG00000118513#ENST00000525369#Myb, Myb-Like, and SANT Domain Containing Genes#Cmyb_C, LMSTEN$#ENSP00000434723#ENSG00000118513#ENST00000528774#Myb, Myb-Like, and SANT Domain Containing Genes#Cmyb_C, LMSTEN$#ENSP00000436605#ENSG00000118513#ENST00000533624#Myb, Myb-Like, and SANT Domain Containing Genes#Cmyb_C$#ENSP00000435055#ENSG00000118513#ENST00000534044#Myb, Myb-Like, and SANT Domain Containing Genes#Cmyb_C, LMSTEN$#ENSP00000432851#ENSG00000118513#ENST00000534121#Myb, Myb-Like, and SANT Domain Containing Genes#Cmyb_C, LMSTEN FALSE 1554 ENSG00000185697 MYBL1 Myb/SANT Yes Known motif Monomer or homomultimer High-throughput in vitro None Contains 3 Myb DBDs IPR001005;IPR009057;IPR012642;IPR015395;IPR017877;IPR017930 4603 MYB proto-oncogene like 1 [Source:HGNC Symbol;Acc:HGNC:7547] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:7987850 Yes 1a1, Direct HQ evidence Laura Campitelli Arttu Jolma Yes $#ENSG00000185697#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:7987850 $#ENSP00000429633#ENSG00000185697#ENST00000522677#Myb, Myb-Like, and SANT Domain Containing Genes#Cmyb_C, LMSTEN$#ENSP00000428011#ENSG00000185697#ENST00000524176#Myb, Myb-Like, and SANT Domain Containing Genes#Cmyb_C, LMSTEN$#ENSP00000428265#ENSG00000185697#ENST00000517885#Myb, Myb-Like, and SANT Domain Containing Genes#Cmyb_C FALSE 1555 ENSG00000101057 MYBL2 Myb/SANT Yes Known motif Monomer or homomultimer High-throughput in vitro None Contains 3 Myb DBDs IPR001005;IPR009057;IPR015395;IPR017877;IPR017930; 4605 MYB proto-oncogene like 2 [Source:HGNC Symbol;Acc:HGNC:7548] None DBD and Full Yes None None a Yes TF Gene Candidate_DNA-Binding: sequence-specific_DNA Binding_PMIDS:1861984;8631934;11997503 Yes 1a1, Direct HQ evidence Matt Weirauch Jussi Taipale Yes $#ENSG00000101057#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:10770937$#ENSG00000101057#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:10770937 $#ENSP00000217026#ENSG00000101057#ENST00000217026#Myb, Myb-Like, and SANT Domain Containing Genes#Cmyb_C$#ENSP00000380072#ENSG00000101057#ENST00000396863#Myb, Myb-Like, and SANT Domain Containing Genes#Cmyb_C FALSE 1556 ENSG00000176182 MYPOP Myb/SANT Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Contains a single Myb-like domain. Mouse ortholog has motif IPR001005;IPR017877;IPR028002; 339344 Myb-related transcription factor, partner of profilin [Source:HGNC Symbol;Acc:HGNC:20178] None not tested not tested None None c No No Yes 1a1, Direct HQ evidence Pratyush Das Arttu Jolma No $#ENSG00000176182#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019 $#ENSP00000325402#ENSG00000176182#ENST00000322217#Myb, Myb-Like, and SANT Domain Containing Genes# FALSE 1557 ENSG00000162601 MYSM1 Myb/SANT Yes Likely to be sequence specific TF Low specificity DNA-binding protein No motif None MYSM1 has been shown to bind DNA. This interaction requires the MYSM1 Myb but not the SWIRM domain (PMID: 17428495). Domain sequence alignment places it near DNA-binding Myb domains but scores slightly higher as a SANT rather than Myb domain based on Prosite patterns. Given that most Myb proteins that bind DNA sequence specifically have multiple Myb domains in an array, this protein could bind DNA sequence non-specifically with its single Myb domain. IPR000555;IPR001005;IPR007526;IPR009057;IPR017884; 114803 Myb like, SWIRM and MPN domains 1 [Source:HGNC Symbol;Acc:HGNC:29401] None not tested not tested None None c Yes No No 4a, two or more datasets predict it as a TF Sam Lambert Laura Campitelli No None $#ENSP00000478391#ENSG00000162601#ENST00000622766#Myb, Myb-Like, and SANT Domain Containing Genes#JAB, Prok-JAB$#ENSP00000418734#ENSG00000162601#ENST00000472487#Myb, Myb-Like, and SANT Domain Containing Genes#JAB, Prok-JAB, SWIRM FALSE 1558 ENSG00000141027 NCOR1 Myb/SANT No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Contains 2 SANT domains, and no other putative DNA-binding domains. Member of N-CoR deacetylase complex (PMID: 14527417). IPR001005;IPR009057;IPR017884; 9611 nuclear receptor corepressor 1 [Source:HGNC Symbol;Acc:HGNC:7672] None Full not tested None None x Yes TF Gene_Transcription Factor Binding: tf co-factor binding; Transcription Regulatory Activity: heterochromatin interaction/binding_TF PPI_PMIDS:11997503;12628926 No 4a, two or more datasets predict it as a TF Laura Campitelli Arttu Jolma Yes None $#ENSP00000268712#ENSG00000141027#ENST00000268712#Myb, Myb-Like, and SANT Domain Containing Genes#GPS2_interact$#ENSP00000379189#ENSG00000141027#ENST00000395848#Myb, Myb-Like, and SANT Domain Containing Genes#GPS2_interact$#ENSP00000379192#ENSG00000141027#ENST00000395851#Myb, Myb-Like, and SANT Domain Containing Genes#GPS2_interact$#ENSP00000407998#ENSG00000141027#ENST00000411510#Myb, Myb-Like, and SANT Domain Containing Genes#GPS2_interact$#ENSP00000389839#ENSG00000141027#ENST00000436068#Myb, Myb-Like, and SANT Domain Containing Genes#$#ENSP00000387727#ENSG00000141027#ENST00000436828#Myb, Myb-Like, and SANT Domain Containing Genes#GPS2_interact$#ENSP00000462308#ENSG00000141027#ENST00000582357#Myb, Myb-Like, and SANT Domain Containing Genes#GPS2_interact$#ENSP00000379190#ENSG00000141027#ENST00000395849#Myb, Myb-Like, and SANT Domain Containing Genes#FAM27$#ENSP00000463169#ENSG00000141027#ENST00000580554#Myb, Myb-Like, and SANT Domain Containing Genes#$#ENSP00000474008#ENSG00000141027#ENST00000603989#Myb, Myb-Like, and SANT Domain Containing Genes# FALSE 1559 ENSG00000196498 NCOR2 Myb/SANT No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Contains 2 SANT domains, and no other putative DNA-binding domains IPR001005;IPR009057;IPR017884; 9612 Nuclear receptor corepressor 2 [Source:HGNC Symbol;Acc:HGNC:7673] None not tested not tested None None x Yes No No 4a, two or more datasets predict it as a TF Sam Lambert Arttu Jolma Yes None $#ENSP00000384202#ENSG00000196498#ENST00000404621#Myb, Myb-Like, and SANT Domain Containing Genes#GPS2_interact$#ENSP00000384018#ENSG00000196498#ENST00000405201#Myb, Myb-Like, and SANT Domain Containing Genes#GPS2_interact, Spt20$#ENSP00000400281#ENSG00000196498#ENST00000429285#Myb, Myb-Like, and SANT Domain Containing Genes#GPS2_interact$#ENSP00000402808#ENSG00000196498#ENST00000458234#Myb, Myb-Like, and SANT Domain Containing Genes#GPS2_interact$#ENSP00000405367#ENSG00000196498#ENST00000420698#Myb, Myb-Like, and SANT Domain Containing Genes#GPS2_interact$#ENSP00000407357#ENSG00000196498#ENST00000413172#Myb, Myb-Like, and SANT Domain Containing Genes#$#ENSP00000391389#ENSG00000196498#ENST00000418829#Myb, Myb-Like, and SANT Domain Containing Genes#$#ENSP00000398963#ENSG00000196498#ENST00000440337#Myb, Myb-Like, and SANT Domain Containing Genes#$#ENSP00000408247#ENSG00000196498#ENST00000448614#Myb, Myb-Like, and SANT Domain Containing Genes#$#ENSP00000443689#ENSG00000196498#ENST00000542927#Myb, Myb-Like, and SANT Domain Containing Genes#DivIC, GPS2_interact FALSE 1560 ENSG00000019485 PRDM11 Myb/SANT No Unlikely to be sequence specific TF Not a DNA binding protein No motif None SANT domain containing protein. Mouse Prdm11 contains Myb-like domain and binds DNA in PBM experiments but has low sequence identity (21%) None None PR/SET domain 11 None not tested Yes None SANT domain containing protein. Mouse Prdm11 contains Myb-like domain and binds DNA in PBM experiments but has low sequence identity (21%) No No No No Protein added after initial stage, no initial assesment Arttu Jolma Sam Lambert No None None FALSE 1561 ENSG00000089902 RCOR1 Myb/SANT No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Contains 2 SANT domains, and no other putative DNA-binding domains. Plays a well-established co-repressor role in the histone LSD1/RCOR1 de-methylase complex. There is some evidence that the protein contacts extranucleosomal DNA (PMID: 25916846). IPR000949;IPR001005;IPR009057;IPR017884 23186 REST corepressor 1 [Source:HGNC Symbol;Acc:HGNC:17441] None DBD not tested None None a Yes No No 4a, two or more datasets predict it as a TF Arttu Jolma Yimeng Yin Yes $#ENSG00000089902#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:10449787 $#ENSP00000262241#ENSG00000089902#ENST00000262241#Myb, Myb-Like, and SANT Domain Containing Genes#ELM2 FALSE 1562 ENSG00000167771 RCOR2 Myb/SANT No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Contains 2 SANT domains, and no other putative DNA-binding domains IPR000949;IPR001005;IPR009057;IPR017884 283248 REST corepressor 2 [Source:HGNC Symbol;Acc:HGNC:27455] None DBD and Full not tested None None a Yes TF Gene_Transcription Factor Binding: tf co-factor binding_Other_PMIDS:10449787;16079794 Yes 3a, decent circumstantial evidence for its role as Yimeng Yin Arttu Jolma Yes $#ENSG00000167771#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000301459#ENSG00000167771#ENST00000301459#Myb, Myb-Like, and SANT Domain Containing Genes#ELM2 FALSE 1563 ENSG00000117625 RCOR3 Myb/SANT No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Contains 2 SANT domains, and no other putative DNA-binding domains. RCOR3 SANT domains are known to facilitate PPIs. Known co-repressor - likely recruited by multiple TFs, as reviewed in (PMID: 24820421). IPR000949;IPR001005;IPR009057;IPR017884 55758 REST corepressor 3 [Source:HGNC Symbol;Acc:HGNC:25594] None DBD and Full Yes None None b Yes No Yes 4a, two or more datasets predict it as a TF Tim Hughes Yimeng Yin Yes $#ENSG00000117625#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000355972#ENSG00000117625#ENST00000367005#Myb, Myb-Like, and SANT Domain Containing Genes#ELM2$#ENSP00000355973#ENSG00000117625#ENST00000367006#Myb, Myb-Like, and SANT Domain Containing Genes#ELM2$#ENSP00000413929#ENSG00000117625#ENST00000419091#Myb, Myb-Like, and SANT Domain Containing Genes#ELM2$#ENSP00000398558#ENSG00000117625#ENST00000452621#Myb, Myb-Like, and SANT Domain Containing Genes#ELM2$#ENSP00000433441#ENSG00000117625#ENST00000534460#Myb, Myb-Like, and SANT Domain Containing Genes# FALSE 1564 ENSG00000102038 SMARCA1 Myb/SANT No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None SMARCA1 contains a truncated Myb-like and SANT domain. Given the presence of the Myb-like domain, and other domains known to associated with DNA (DEAD box helicase) it likely associates with DNA non-sequence-specifically IPR000330;IPR001005;IPR001650;IPR009057;IPR014001;IPR015194;IPR015195;IPR017884;IPR020838;IPR027417 6594 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 [S None not tested not tested None None x Yes TF Gene Candidate_Transcription Regulatory Activity: heterochromatin interaction/binding_DNA Binding_PMIDS:1408766;10415348;11031099 No 4a, two or more datasets predict it as a TF Jussi Taipale Sam Lambert Yes None $#ENSP00000360162#ENSG00000102038#ENST00000371121#Myb, Myb-Like, and SANT Domain Containing Genes#DBINO, DEAD, HAND, HDA2-3, Helicase_C, ResIII, SNF$#ENSP00000360163#ENSG00000102038#ENST00000371122#Myb, Myb-Like, and SANT Domain Containing Genes#DBINO, DEAD, HAND, HDA2-3, Helicase_C, ResIII, SNF$#ENSP00000360164#ENSG00000102038#ENST00000371123#Myb, Myb-Like, and SANT Domain Containing Genes#DBINO, DEAD, ERCC3_RAD25_C, HAND, HDA2-3, Helicase FALSE 1565 ENSG00000153147 SMARCA5 Myb/SANT No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif Has a putative AT-hook Contains a SANT, and Myb-like domain. Chromatin remodeling complex component that operates in DNA repair (PMID: 24990377); interacts with DNA, but presumably in non-sequence specific manner. IPR000330;IPR001005;IPR001650;IPR009057;IPR014001;IPR015194;IPR015195;IPR017884;IPR020838;IPR027417 8467 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 [S None not tested Yes None None x Yes TF Gene Candidate_Transcription Regulatory Activity: heterochromatin interaction/binding; DNA-Binding: non-sequence-specific_Non-specific DNA_PMIDS:12368916 No 4a, two or more datasets predict it as a TF Arttu Jolma Matt Weirauch Yes None $#ENSP00000283131#ENSG00000153147#ENST00000283131#Myb, Myb-Like, and SANT Domain Containing Genes#DBINO, DEAD, ERCC3_RAD25_C, HAND, HDA2-3, Helicase FALSE 1566 ENSG00000173473 SMARCC1 Myb/SANT No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Contains 1 SANT domain, and no other putative DNA-binding domains. Given that SMARCC1 is part of the Swi/Snf chromatin remodelling complex, its Myb/Sant domain is likely involved in binding histone tails. Available motif logos ares likely specificifities of SMARCC1 interactors. IPR000953;IPR001005;IPR001357;IPR007526;IPR009057;IPR017884 6599 SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1 [Sou None Full Yes None WRONG SITE ChIP-seq model has a bZIP CRE-like sequence, SWI-SNF class nucleosome remodeling complex protein (active ATP-ase) x Yes TF Gene Candidate_Transcription Factor Binding: tf co-factor binding; Transcription Regulatory Activity: heterochromatin interaction/binding_TF PPI; Transactivation_PMIDS:15923603;11018012 No 2a1, Lower confidence direct evidence Sam Lambert Pratyush Das Yes None $#ENSP00000254480#ENSG00000173473#ENST00000254480#Myb, Myb-Like, and SANT Domain Containing Genes#SWIRM, SWIRM-assoc_1, SWIRM-assoc_2, SWIRM-assoc_3 FALSE 1567 ENSG00000139613 SMARCC2 Myb/SANT No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Contains 1 SANT domain, and no other putative DNA-binding domains. Available motif logos ares likely specificifities of SMARCC2 interactors. IPR000953;IPR001005;IPR001357;IPR007526;IPR009057;IPR017884 6601 SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2 [Sou None not tested not tested None WRONG SITE ChIP-seq model has a bZIP CRE-like sequence, SWI-SNF class nucleosome remodeling complex protein (active ATP-ase) x Yes No No 2a1, Lower confidence direct evidence Arttu Jolma Pratyush Das Yes None $#ENSP00000267064#ENSG00000139613#ENST00000267064#Myb, Myb-Like, and SANT Domain Containing Genes#Chromo, SWIRM, SWIRM-assoc_1, SWIRM-assoc_2, SWIRM$#ENSP00000302919#ENSG00000139613#ENST00000347471#Myb, Myb-Like, and SANT Domain Containing Genes#Chromo, SWIRM, SWIRM-assoc_1, SWIRM-assoc_2, SWIRM$#ENSP00000377591#ENSG00000139613#ENST00000394023#Myb, Myb-Like, and SANT Domain Containing Genes#Chromo, SWIRM, SWIRM-assoc_1, SWIRM-assoc_2, SWIRM$#ENSP00000449396#ENSG00000139613#ENST00000550164#Myb, Myb-Like, and SANT Domain Containing Genes#Chromo, SWIRM, SWIRM-assoc_1, SWIRM-assoc_2, SWIRM FALSE 1568 ENSG00000165684 SNAPC4 Myb/SANT Yes Likely to be sequence specific TF Monomer or homomultimer No motif None EMSA data available showing it can specifically bind DNA (PMID: 9418884) IPR001005;IPR009057;IPR017877;IPR017930 6621 small nuclear RNA activating complex polypeptide 4 [Source:HGNC Symbol;Acc:HGNC:11137] None DBD not tested None None a Yes TF Gene_DNA-Binding: non-sequence-specific; Basal Transcription Factor; Transcription Factor Binding: tf co-factor binding_Co-activation; DNA Binding; TF PPI_PMIDS:9418884 Yes 3a, decent circumstantial evidence for its role as Sam Lambert Matt Weirauch Yes $#ENSG00000165684#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000165684#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:9418884 $#ENSP00000298532#ENSG00000165684#ENST00000298532#Myb, Myb-Like, and SANT Domain Containing Genes#$#ENSP00000490037#ENSG00000165684#ENST00000637388#Myb, Myb-Like, and SANT Domain Containing Genes# FALSE 1569 ENSG00000276234 TADA2A Myb/SANT No Unlikely to be sequence specific TF Not a DNA binding protein No motif None TADA2A contains a single SANT domain and is thus unlikely to bind DNA IPR001005;IPR007526;IPR009057;IPR016827;IPR017884 6871 transcriptional adaptor 2A [Source:HGNC Symbol;Acc:HGNC:11531] None not tested not tested None None No Yes No Yes 3a, decent circumstantial evidence for its role as Jussi Taipale Pratyush Das Yes $#ENSG00000276234#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:8552087 $#ENSP00000481091#ENSG00000276234#ENST00000615182#Myb, Myb-Like, and SANT Domain Containing Genes#SWIRM$#ENSP00000477709#ENSG00000276234#ENST00000612272#Myb, Myb-Like, and SANT Domain Containing Genes#SWIRM$#ENSP00000484884#ENSG00000276234#ENST00000621780#Myb, Myb-Like, and SANT Domain Containing Genes#$#ENSP00000478418#ENSG00000276234#ENST00000614112#Myb, Myb-Like, and SANT Domain Containing Genes# FALSE 1570 ENSG00000173011 TADA2B Myb/SANT No Unlikely to be sequence specific TF Not a DNA binding protein No motif None TADA2B contains a single SANT domain and is thus unlikely to bind DNA IPR000433;IPR001005;IPR009057;IPR016827;IPR017884; 93624 transcriptional adaptor 2B [Source:HGNC Symbol;Acc:HGNC:30781] None not tested not tested None None c Yes No Yes 4a, two or more datasets predict it as a TF Sam Lambert Jussi Taipale Yes $#ENSG00000173011#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000308022#ENSG00000173011#ENST00000310074#Myb, Myb-Like, and SANT Domain Containing Genes#ZZ, zf-B_box$#ENSP00000423947#ENSG00000173011#ENST00000512388#Myb, Myb-Like, and SANT Domain Containing Genes#$#ENSP00000422398#ENSG00000173011#ENST00000506692#Myb, Myb-Like, and SANT Domain Containing Genes#$#ENSP00000423181#ENSG00000173011#ENST00000515646#Myb, Myb-Like, and SANT Domain Containing Genes# FALSE 1571 ENSG00000249961 TERB1 Myb/SANT Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Contains a single Myb domain (with slightly less similarity to a SANT domain). This domain has been shown to be involved in PPIs (PMID: 24413433), but this may not be mutually exclusive with DNA-binding. IPR001005;IPR009057;IPR016024; 283847 telomere repeat binding bouquet formation protein 1 [Source:HGNC Symbol;Acc:HGNC:26675] None not tested not tested None None No Yes No No 5a, one of the source datasets predicts is as a TF Sam Lambert Yimeng Yin No None $#ENSP00000462482#ENSG00000249961#ENST00000559050#Myb, Myb-Like, and SANT Domain Containing Genes#Atx10homo_assoc, HEAT$#ENSP00000462842#ENSG00000249961#ENST00000559403#Myb, Myb-Like, and SANT Domain Containing Genes#$#ENSP00000463762#ENSG00000249961#ENST00000433154#Myb, Myb-Like, and SANT Domain Containing Genes#Atx10homo_assoc, DUF4704$#ENSP00000462883#ENSG00000249961#ENST00000558713#Myb, Myb-Like, and SANT Domain Containing Genes#Atx10homo_assoc, DUF4704 FALSE 1572 ENSG00000147601 TERF1 Myb/SANT Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Contains 1 Myb domain, and has structural evidence of DNA-binding (PDB: 1IV6). Subunit of Shelterin, a complex that specifically binds telomeres (PMID: 16166375). IPR001005;IPR009057;IPR013867;IPR017357;IPR017930; 7013 telomeric repeat binding factor 1 [Source:HGNC Symbol;Acc:HGNC:11728] 1IV6 not tested Yes None None c Yes No No 1a1, Direct HQ evidence Matt Weirauch Laura Campitelli No None $#ENSP00000276602#ENSG00000147601#ENST00000276602#Myb, Myb-Like, and SANT Domain Containing Genes#TRF$#ENSP00000276603#ENSG00000147601#ENST00000276603#Myb, Myb-Like, and SANT Domain Containing Genes#TRF$#ENSP00000430121#ENSG00000147601#ENST00000517390#Myb, Myb-Like, and SANT Domain Containing Genes#TRF$#ENSP00000428838#ENSG00000147601#ENST00000518874#Myb, Myb-Like, and SANT Domain Containing Genes#TRF FALSE 1573 ENSG00000132604 TERF2 Myb/SANT Yes Inferred motif Monomer or homomultimer High-throughput in vitro None The sequence in the crystal structure (PDB:1VFC), GTTAGGGTTAGGG, matches the inferred mouse motif. IPR001005;IPR009057;IPR013867;IPR017357;IPR017930; 7014 telomeric repeat binding factor 2 [Source:HGNC Symbol;Acc:HGNC:11729] 1VFC Full not tested None None c Yes No No 1a1, Direct HQ evidence Sam Lambert Arttu Jolma No None $#ENSP00000254942#ENSG00000132604#ENST00000254942#Myb, Myb-Like, and SANT Domain Containing Genes#TERF2_RBM, TRF$#ENSP00000454955#ENSG00000132604#ENST00000567296#Myb, Myb-Like, and SANT Domain Containing Genes#PCI, TRF$#ENSP00000456022#ENSG00000132604#ENST00000566750#Myb, Myb-Like, and SANT Domain Containing Genes#PCI, TERF2_RBM, TRF$#ENSP00000475507#ENSG00000132604#ENST00000569584#Myb, Myb-Like, and SANT Domain Containing Genes#TERF2_RBM, TRF$#ENSP00000463079#ENSG00000132604#ENST00000566051#Myb, Myb-Like, and SANT Domain Containing Genes# FALSE 1574 ENSG00000166848 TERF2IP Myb/SANT No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Contains a single Myb-like domain. Forms a complex with TERF2, where it modulates the binding of TERF2 to telomeres (PMID: 25675958). Unclear if TERF2IP contacts DNA directly. IPR009057;IPR015010;IPR021661; 54386 TERF2 interacting protein [Source:HGNC Symbol;Acc:HGNC:19246] None not tested not tested None Taipale Lab, Unpublished HT-SELEX, direct x No No Yes 1a1, Direct HQ evidence Arttu Jolma Yimeng Yin No $#ENSG00000166848#GO:0051092#positive regulation of NF-kappaB transcription factor activity#ISS - GO_REF:0000024 $#ENSP00000300086#ENSG00000166848#ENST00000300086#Myb, Myb-Like, and SANT Domain Containing Genes#BRCT_2, Myb_DNA-bind_2, Rap1_C$#ENSP00000456092#ENSG00000166848#ENST00000564671#Myb, Myb-Like, and SANT Domain Containing Genes# FALSE 1575 ENSG00000125482 TTF1 Myb/SANT Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Contains Myb and Myb-like domains, and is annotated as a Pol1 terminator. DNA-binding has been demonstrated in vitro via EMSA (PMID: 7597036). IPR001005;IPR017877 7270 transcription termination factor 1 [Source:HGNC Symbol;Acc:HGNC:12397] None not tested Yes None None x Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:7720715;9049305 No 4a, two or more datasets predict it as a TF Jussi Taipale Laura Campitelli No $#ENSG00000125482#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000333920#ENSG00000125482#ENST00000334270#Myb, Myb-Like, and SANT Domain Containing Genes#$#ENSP00000481441#ENSG00000125482#ENST00000612514#Myb, Myb-Like, and SANT Domain Containing Genes#Myb_DNA-bind_6 FALSE 1576 ENSG00000036549 ZZZ3 Myb/SANT Yes Known motif Monomer or homomultimer High-throughput in vitro None Contains 1 Myb DBD IPR000433;IPR001005;IPR009057;IPR017930 26009 zinc finger ZZ-type containing 3 [Source:HGNC Symbol;Acc:HGNC:24523] None DBD and Full Yes None None b Yes No No 1a1, Direct HQ evidence Arttu Jolma Jussi Taipale No None $#ENSP00000359834#ENSG00000036549#ENST00000370798#Myb, Myb-Like, and SANT Domain Containing Genes#ZZ$#ENSP00000359837#ENSG00000036549#ENST00000370801#Myb, Myb-Like, and SANT Domain Containing Genes#ZZ$#ENSP00000392408#ENSG00000036549#ENST00000414381#Myb, Myb-Like, and SANT Domain Containing Genes#$#ENSP00000393779#ENSG00000036549#ENST00000433749#Myb, Myb-Like, and SANT Domain Containing Genes# FALSE 1577 ENSG00000182979 MTA1 Myb/SANT; GATA No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None Contains a GATA and SANT domain. Unclear whether the GATA domain is a bona fide DBD as the MTA/RERE family domains are atypical to human GATA domains (see alignment). In CIS-BP there is one protein from C.elegans that shares domain homology and binds a GATA motif (elg-27, ChIP-seq). The GATA ZnF domain of MTA1 is required for its interaction with RBBP4 and RBBP7 (PMID:18067919). Full-length protein has been tried in HT-SELEX and did not yield a motif IPR000679;IPR000949;IPR001005;IPR001025;IPR009057;IPR017884 9112 metastasis associated 1 [Source:HGNC Symbol;Acc:HGNC:7410] None Full not tested None PMID: 26869315 Protein is a component of the nucleosome remodelling and deacetylase (NuRD) that isnt supposed to contact DNA directly x Yes TF Gene_DNA-Binding: non-sequence-specific; Transcription Factor Binding: tf co-factor binding_Non-specific DNA_PMIDS:12431981 No 4a, two or more datasets predict it as a TF Yimeng Yin Pratyush Das Yes $#ENSG00000182979#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002 $#ENSP00000333633#ENSG00000182979#ENST00000331320#Myb, Myb-Like, and SANT Domain Containing Genes#BAH, ELM2$#ENSP00000394106#ENSG00000182979#ENST00000434050#Myb, Myb-Like, and SANT Domain Containing Genes#$#ENSP00000385702#ENSG00000182979#ENST00000406191#Myb, Myb-Like, and SANT Domain Containing Genes#BAH, ELM2 FALSE 1578 ENSG00000149480 MTA2 Myb/SANT; GATA No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None Contains a GATA and SANT domain. Unclear whether the GATA domain is a bona fide DBD as the MTA/RERE family domains are atypical to human GATA domains (see alignment). In CIS-BP there is one protein from C.elegans that shares domain homology and binds a GATA motif (elg-27, ChIP-seq). Full-length protein has been tried in HT-SELEX, and DBD has been tried on PBM - neither yielded motifs IPR000679;IPR000949;IPR001005;IPR001025;IPR009057;IPR017884 9219 metastasis associated 1 family member 2 [Source:HGNC Symbol;Acc:HGNC:7411] None Full Yes None PMID: 26869315 Protein is a component of the nucleosome remodelling and deacetylase (NuRD) that isnt supposed to contact DNA directly x Yes TF Gene_Transcription Regulatory Activity: heterochromatin interaction/binding_Transactivation_PMIDS:11749719;15020045 No 4a, two or more datasets predict it as a TF Pratyush Das Yimeng Yin Yes $#ENSG00000149480#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002 $#ENSP00000278823#ENSG00000149480#ENST00000278823#Myb, Myb-Like, and SANT Domain Containing Genes#BAH, ELM2$#ENSP00000431346#ENSG00000149480#ENST00000524902#Myb, Myb-Like, and SANT Domain Containing Genes#ELM2$#ENSP00000431797#ENSG00000149480#ENST00000527204#Myb, Myb-Like, and SANT Domain Containing Genes#ELM2 FALSE 1579 ENSG00000057935 MTA3 Myb/SANT; GATA No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None Contains a GATA and SANT domain. Unclear whether the GATA domain is a bona fide DBD as the MTA/RERE family domains are atypical to human GATA domains (see alignment). In CIS-BP there is one protein from C.elegans that shares domain homology and binds a GATA motif (elg-27, ChIP-seq). Hasnt been tried in any in vitro assays IPR000679;IPR000949;IPR001005;IPR001025;IPR009057;IPR017884 57504 metastasis associated 1 family member 3 [Source:HGNC Symbol;Acc:HGNC:23784] None not tested not tested None PMID: 26869315 Protein is a component of the nucleosome remodelling and deacetylase (NuRD) that isnt supposed to contact DNA directly x Yes No No 4a, two or more datasets predict it as a TF Laura Campitelli Sam Lambert Yes $#ENSG00000057935#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002 $#ENSP00000384249#ENSG00000057935#ENST00000406652#Myb, Myb-Like, and SANT Domain Containing Genes#BAH, ELM2$#ENSP00000385045#ENSG00000057935#ENST00000407270#Myb, Myb-Like, and SANT Domain Containing Genes#BAH, ELM2$#ENSP00000383973#ENSG00000057935#ENST00000405592#Myb, Myb-Like, and SANT Domain Containing Genes#BAH, ELM2$#ENSP00000388722#ENSG00000057935#ENST00000433553#Myb, Myb-Like, and SANT Domain Containing Genes# FALSE 1580 ENSG00000142599 RERE Myb/SANT; GATA No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None Contains a GATA and SANT domain. Unclear whether the GATA domain is a bona fide DBD as the MTA/RERE family domains are atypical to human GATA domains (see alignment). In CIS-BP there is one protein from C.elegans that shares domain homology and binds a GATA motif (elg-27, ChIP-seq). Has been tried as a DBD in HT-SELEX but did not yield a motif IPR000679;IPR000949;IPR001005;IPR001025;IPR002951;IPR009057;IPR017884; 473 arginine-glutamic acid dipeptide repeats [Source:HGNC Symbol;Acc:HGNC:9965] None DBD Yes None None b Yes No No 4a, two or more datasets predict it as a TF Sam Lambert Jussi Taipale Yes $#ENSG00000142599#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002 $#ENSP00000338629#ENSG00000142599#ENST00000337907#Myb, Myb-Like, and SANT Domain Containing Genes#Atrophin-1, BAH, ELM2$#ENSP00000383700#ENSG00000142599#ENST00000400908#Myb, Myb-Like, and SANT Domain Containing Genes#Atrophin-1, BAH, ELM2$#ENSP00000422246#ENSG00000142599#ENST00000476556#Myb, Myb-Like, and SANT Domain Containing Genes#Atrophin-1$#ENSP00000465271#ENSG00000142599#ENST00000468247#Myb, Myb-Like, and SANT Domain Containing Genes#$#ENSP00000423451#ENSG00000142599#ENST00000505225#Myb, Myb-Like, and SANT Domain Containing Genes#Atrophin-1, Dsh_C$#ENSP00000464847#ENSG00000142599#ENST00000488215#Myb, Myb-Like, and SANT Domain Containing Genes#$#ENSP00000423259#ENSG00000142599#ENST00000514428#Myb, Myb-Like, and SANT Domain Containing Genes#BAH FALSE 1581 ENSG00000197056 ZMYM1 MYM-type ZF No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR008906;IPR010507;IPR011017;IPR012337;IPR025398 79830 zinc finger MYM-type containing 1 [Source:HGNC Symbol;Acc:HGNC:26253] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Yimeng Yin Jussi Taipale No $#ENSG00000197056#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000352920#ENSG00000197056#ENST00000359858#Other#DUF4371, Dimer_Tnp_hAT, zf-FCS$#ENSP00000362427#ENSG00000197056#ENST00000373330#Other#DUF4371, Dimer_Tnp_hAT, zf-FCS$#ENSP00000394233#ENSG00000197056#ENST00000417119#Other#zf-FCS$#ENSP00000482579#ENSG00000197056#ENST00000611874#Other#DUF4371, Dimer_Tnp_hAT, zf-FCS FALSE 1582 ENSG00000121741 ZMYM2 MYM-type ZF No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR010507;IPR011017;IPR021893 7750 zinc finger MYM-type containing 2 [Source:HGNC Symbol;Acc:HGNC:12989] None not tested not tested None None No No TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:14651998 Yes 4a, two or more datasets predict it as a TF Yimeng Yin Jussi Taipale No $#ENSG00000121741#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000372324#ENSG00000121741#ENST00000382871#Other#Arc_trans_TRASH, DUF3504, YHS, zf-FCS$#ENSP00000372327#ENSG00000121741#ENST00000382874#Other#Arc_trans_TRASH, DUF3504, YHS, zf-FCS$#ENSP00000479904#ENSG00000121741#ENST00000610343#Other#Arc_trans_TRASH, DUF3504, YHS, zf-FCS$#ENSP00000483904#ENSG00000121741#ENST00000620447#Other#YHS, zf-FCS, zf-FLZ FALSE 1583 ENSG00000147130 ZMYM3 MYM-type ZF No Unlikely to be sequence specific TF Not a DNA binding protein No motif None The cassette of seven znf-MYM domains are used to bind SUMO (PMID: 25133527). Overall, very little is known about this domain or protein. IPR010507;IPR011017;IPR021893 9203 zinc finger MYM-type containing 3 [Source:HGNC Symbol;Acc:HGNC:13054] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Matt Weirauch Arttu Jolma No $#ENSG00000147130#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000322845#ENSG00000147130#ENST00000314425#Other#Arc_trans_TRASH, DUF3504, NosL, YHS, zf-FCS$#ENSP00000363093#ENSG00000147130#ENST00000373981#Other#zf-FCS$#ENSP00000363110#ENSG00000147130#ENST00000373998#Other#Arc_trans_TRASH, DUF3504, NosL, YHS, zf-FCS FALSE 1584 ENSG00000146463 ZMYM4 MYM-type ZF No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Lacks a canonical DBD IPR010507;IPR011017;IPR021893 9202 zinc finger MYM-type containing 4 [Source:HGNC Symbol;Acc:HGNC:13055] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Sam Lambert Yimeng Yin No $#ENSG00000146463#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000322915#ENSG00000146463#ENST00000314607#Other#DUF3504, zf-FCS$#ENSP00000397524#ENSG00000146463#ENST00000441447#Other#$#ENSP00000400506#ENSG00000146463#ENST00000457946#Other#DUF3504, YHS, zf-FCS FALSE 1585 ENSG00000132950 ZMYM5 MYM-type ZF No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Binds to and represses activity of ETV5 based on (PMID: 17126306), but there is no evidence for it binding the DNA itself, so it seems like an co-repressor IPR010507;IPR011017 9205 zinc finger MYM-type containing 5 [Source:HGNC Symbol;Acc:HGNC:13029] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Arttu Jolma Matt Weirauch No $#ENSG00000132950#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IDA - PMID:17126306 $#ENSP00000372361#ENSG00000132950#ENST00000382905#Other#YHS, zf-FCS$#ENSP00000372364#ENSG00000132950#ENST00000382907#Other#$#ENSP00000337034#ENSG00000132950#ENST00000337963#Other#ATPase-cat_bd, zf-FCS$#ENSP00000445779#ENSG00000132950#ENST00000502168#Other#ATPase-cat_bd, zf-FCS FALSE 1586 ENSG00000163867 ZMYM6 MYM-type ZF No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Truncated BED ZF IPR010507;IPR011017;IPR012337;IPR025398 9204 zinc finger MYM-type containing 6 [Source:HGNC Symbol;Acc:HGNC:13050] None not tested not tested None None No Yes No Yes 3a, decent circumstantial evidence for its role as Jussi Taipale Sam Lambert No $#ENSG00000163867#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000326695#ENSG00000163867#ENST00000317538#Other#zf-FCS$#ENSP00000349708#ENSG00000163867#ENST00000357182#Other#DUF4371, zf-FCS$#ENSP00000362430#ENSG00000163867#ENST00000373333#Other#zf-FCS$#ENSP00000391337#ENSG00000163867#ENST00000415531#Other#zf-FCS, zf-FLZ FALSE 1587 ENSG00000004838 ZMYND10 MYND-type ZF No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR002893;IPR017333 51364 zinc finger MYND-type containing 10 [Source:HGNC Symbol;Acc:HGNC:19412] None not tested not tested None None No No Indeterminate - There is no evidence for or against this genes role as a TF__Other_PMIDS:11085536;12629521;16929489 No 5a, one of the source datasets predicts is as a TF Jussi Taipale Matt Weirauch No None $##ENSG00000004838##Other# FALSE 1588 ENSG00000124920 MYRF Ndt80/PhoG Yes Known motif Monomer or homomultimer High-throughput in vitro None Mouse ortholog binds a highly similar motif. IPR008967;IPR024061;IPR025719;IPR026932;IPR030392; 745 myelin regulatory factor [Source:HGNC Symbol;Acc:HGNC:1181] None not tested Yes None None c Yes No No 1a1, Direct HQ evidence Laura Campitelli Tim Hughes Yes $#ENSG00000124920#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002 $#ENSP00000265460#ENSG00000124920#ENST00000265460#Other#MRF_C1, MRF_C2, Peptidase_S74$#ENSP00000278836#ENSG00000124920#ENST00000278836#Other#MRF_C1, MRF_C2, Peptidase_S74$#ENSP00000374253#ENSG00000124920#ENST00000389602#Other#MRF_C1, MRF_C2, Peptidase_S74 FALSE 1589 ENSG00000166268 MYRFL Ndt80/PhoG Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Related to other MYRF TFs, which have related PBM motifs IPR008967;IPR024061;IPR025719;IPR026932;IPR030392; 196446 myelin regulatory factor-like [Source:HGNC Symbol;Acc:HGNC:26316] None not tested not tested None None x Yes No Yes 4a, two or more datasets predict it as a TF Laura Campitelli Pratyush Das No $#ENSG00000166268#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002 $#ENSP00000440626#ENSG00000166268#ENST00000535034#Other#MRF_C2$#ENSP00000447167#ENSG00000166268#ENST00000548892#Other#MRF_C1, MRF_C2 FALSE 1590 ENSG00000086102 NFX1 NFX Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR000967;IPR001374;IPR001841;IPR019786;IPR019787; 4799 nuclear transcription factor, X-box binding 1 [Source:HGNC Symbol;Acc:HGNC:7803] None DBD Yes None None a Yes TF Gene_Single stranded RNA/DNA binding_DNA Binding; Transactivation_PMIDS:7964459 Yes 3a, decent circumstantial evidence for its role as Yimeng Yin Sam Lambert Yes $#ENSG00000086102#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:7964459$#ENSG00000086102#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:7964459 $#ENSP00000317695#ENSG00000086102#ENST00000318524#NF-X1 ZF#$#ENSP00000368836#ENSG00000086102#ENST00000379521#NF-X1 ZF#$#ENSP00000368856#ENSG00000086102#ENST00000379540#NF-X1 ZF#R3H FALSE 1591 ENSG00000170448 NFXL1 NFX Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Likely a TF based on presence of NFX ZF. IPR000967;IPR001841;IPR019786; 152518 nuclear transcription factor, X-box binding like 1 [Source:HGNC Symbol;Acc:HGNC:18726] None not tested not tested None None c Yes No Yes 4a, two or more datasets predict it as a TF Sam Lambert Pratyush Das Yes $#ENSG00000170448#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IBA - GO_REF:0000033 $#ENSP00000333113#ENSG00000170448#ENST00000329043#NF-X1 ZF#$#ENSP00000422037#ENSG00000170448#ENST00000507489#NF-X1 ZF#$#ENSP00000370949#ENSG00000170448#ENST00000381538#NF-X1 ZF# FALSE 1592 ENSG00000109445 ZNF330 NOA36-type ZF No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Protein has IPR010531 domain, Zinc finger protein NOA36, which has not been shown to bind DNA None None Zinc finger protein 330 None not tested not tested None Protein has IPR010531 domain, Zinc finger protein NOA36, which has not been shown to bind DNA No No No No Protein added after initial stage, no initial assesment Arttu Jolma Sam Lambert No None None FALSE 1593 ENSG00000169083 AR Nuclear receptor Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000536;IPR001103;IPR001628;IPR001723;IPR008946; 367 androgen receptor [Source:HGNC Symbol;Acc:HGNC:644] 1R4I DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:7685765;9211894 No 1a1, Direct HQ evidence Yimeng Yin Matt Weirauch Yes $#ENSG00000169083#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:16728402$#ENSG00000169083#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:11477070, PMID:15572661 | TAS - PMID:20$#ENSG00000169083#GO:0004879#ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity#IDA - PMID:17277772$#ENSG00000169083#GO:0004882#androgen receptor activity#IDA - PMID:12799378, PMID:19886863, PMID:20048160,$#ENSG00000169083#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IMP - PMID:21310825 $#ENSP00000363822#ENSG00000169083#ENST00000374690#Nuclear Hormone Receptor#Androgen_recep, Hormone_recep$#ENSP00000379358#ENSG00000169083#ENST00000396043#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000379359#ENSG00000169083#ENST00000396044#Nuclear Hormone Receptor#Androgen_recep$#ENSP00000421155#ENSG00000169083#ENST00000504326#Nuclear Hormone Receptor#Androgen_recep$#ENSP00000479013#ENSG00000169083#ENST00000613054#Nuclear Hormone Receptor#Androgen_recep FALSE 1594 ENSG00000091831 ESR1 Nuclear receptor Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000536;IPR001292;IPR001628;IPR001723;IPR008946;IPR024178;IPR024736; 2099 estrogen receptor 1 [Source:HGNC Symbol;Acc:HGNC:3467] 1HCQ DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:10908317;16636675 Yes 1a1, Direct HQ evidence Yimeng Yin Pratyush Das Yes $#ENSG00000091831#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:12047722$#ENSG00000091831#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:12552091$#ENSG00000091831#GO:0038052#estrogen-activated sequence-specific DNA binding RNA polymerase II transcription factor activity#IDA - PMID:15831516 | IGI - PMID:18722177$#ENSG00000091831#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:10816575$#ENSG00000091831#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:10681512, PMID:9328340 $#ENSP00000206249#ENSG00000091831#ENST00000206249#Nuclear Hormone Receptor#ESR1_C, Hormone_recep, Oest_recep$#ENSP00000385373#ENSG00000091831#ENST00000404742#Nuclear Hormone Receptor#Oest_recep$#ENSP00000384064#ENSG00000091831#ENST00000406599#Nuclear Hormone Receptor#ESR1_C, Hormone_recep, Oest_recep$#ENSP00000401995#ENSG00000091831#ENST00000415488#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000394721#ENSG00000091831#ENST00000427531#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000411105#ENSG00000091831#ENST00000446550#Nuclear Hormone Receptor#Oest_recep$#ENSP00000415934#ENSG00000091831#ENST00000456483#Nuclear Hormone Receptor#Oest_recep FALSE 1595 ENSG00000140009 ESR2 Nuclear receptor Yes Known motif Monomer or homomultimer 100 perc ID - in vitro None None IPR000536;IPR001628;IPR001723;IPR008946;IPR021064;IPR024178;IPR028355; 2100 estrogen receptor 2 [Source:HGNC Symbol;Acc:HGNC:3468] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_Transactivation_PMIDS:9058381;12047722;16484337 Yes 1a1, Direct HQ evidence Jussi Taipale Arttu Jolma Yes $#ENSG00000140009#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:8769313$#ENSG00000140009#GO:0004879#ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity#NAS - PMID:9671811$#ENSG00000140009#GO:0038052#estrogen-activated sequence-specific DNA binding RNA polymerase II transcription factor activity#IDA - PMID:19126643$#ENSG00000140009#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:10681512 $#ENSP00000267525#ENSG00000140009#ENST00000267525#Nuclear Hormone Receptor#ERbeta_N, Hormone_recep$#ENSP00000343925#ENSG00000140009#ENST00000341099#Nuclear Hormone Receptor#ERbeta_N, Hormone_recep$#ENSP00000335551#ENSG00000140009#ENST00000353772#Nuclear Hormone Receptor#ERbeta_N, Hormone_recep$#ENSP00000452426#ENSG00000140009#ENST00000553796#Nuclear Hormone Receptor#ERbeta_N, Hormone_recep$#ENSP00000450699#ENSG00000140009#ENST00000554572#Nuclear Hormone Receptor#ERbeta_N, Hormone_recep$#ENSP00000450488#ENSG00000140009#ENST00000555278#Nuclear Hormone Receptor#ERbeta_N, Hormone_recep$#ENSP00000451582#ENSG00000140009#ENST00000557772#Nuclear Hormone Receptor#ERbeta_N, Hormone_recep$#ENSP00000351412#ENSG00000140009#ENST00000358599#Nuclear Hormone Receptor#ERbeta_N, Hormone_recep$#ENSP00000452485#ENSG00000140009#ENST00000556275#Nuclear Hormone Receptor#ERbeta_N, Hormone_recep FALSE 1596 ENSG00000173153 ESRRA Nuclear receptor Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000536;IPR001628;IPR001723;IPR008946;IPR024178;IPR027289 2101 estrogen related receptor alpha [Source:HGNC Symbol;Acc:HGNC:3471] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:9271417 Yes 1a1, Direct HQ evidence Arttu Jolma Jussi Taipale Yes $#ENSG00000173153#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000173153#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000173153#GO:0004879#ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity#TAS - PMID:9286700 $#ENSP00000000442#ENSG00000173153#ENST00000000442#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000384851#ENSG00000173153#ENST00000405666#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000385971#ENSG00000173153#ENST00000406310#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000441970#ENSG00000173153#ENST00000468670#Nuclear Hormone Receptor#$#ENSP00000444710#ENSG00000173153#ENST00000545035#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000439896#ENSG00000173153#ENST00000539594#Nuclear Hormone Receptor#Hormone_recep FALSE 1597 ENSG00000119715 ESRRB Nuclear receptor Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000536;IPR001628;IPR001723;IPR008946;IPR024178;IPR027289 2103 estrogen related receptor beta [Source:HGNC Symbol;Acc:HGNC:3473] 1LO1 DBD Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_Co-activation_PMIDS:8626619;15766247 Yes 1a1, Direct HQ evidence Matt Weirauch Jussi Taipale Yes $#ENSG00000119715#GO:0004879#ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity#TAS - PMID:9344655 $#ENSP00000422488#ENSG00000119715#ENST00000509242#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000451658#ENSG00000119715#ENST00000556177#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000370270#ENSG00000119715#ENST00000380887#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000424992#ENSG00000119715#ENST00000512784#Nuclear Hormone Receptor#Hormone_recep FALSE 1598 ENSG00000196482 ESRRG Nuclear receptor Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000536;IPR001628;IPR001723;IPR003078;IPR008946;IPR024178;IPR027289; 2104 estrogen related receptor gamma [Source:HGNC Symbol;Acc:HGNC:3474] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:15149736 No 1a1, Direct HQ evidence Pratyush Das Yimeng Yin Yes $#ENSG00000196482#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IEA - GO_REF:0000019$#ENSG00000196482#GO:0003708#retinoic acid receptor activity#IEA - GO_REF:0000002 $#ENSP00000352077#ENSG00000196482#ENST00000359162#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000353108#ENSG00000196482#ENST00000360012#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000354584#ENSG00000196482#ENST00000361395#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000355904#ENSG00000196482#ENST00000366937#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000355905#ENSG00000196482#ENST00000366938#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000355907#ENSG00000196482#ENST00000366940#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000386171#ENSG00000196482#ENST00000408911#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000419514#ENSG00000196482#ENST00000475275#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000419155#ENSG00000196482#ENST00000487276#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000419594#ENSG00000196482#ENST00000493603#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000417374#ENSG00000196482#ENST00000493748#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000481528#ENSG00000196482#ENST00000616180#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000418629#ENSG00000196482#ENST00000463665#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000417900#ENSG00000196482#ENST00000469486#Nuclear Hormone Receptor# FALSE 1599 ENSG00000101076 HNF4A Nuclear receptor Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000003;IPR000536;IPR001628;IPR001723;IPR003068;IPR008946 3172 hepatocyte nuclear factor 4 alpha [Source:HGNC Symbol;Acc:HGNC:5024] 3CBB DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:15581617 Yes 1a1, Direct HQ evidence Arttu Jolma Pratyush Das Yes $#ENSG00000101076#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#ISS - GO_REF:0000024$#ENSG00000101076#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:10330009, PMID:12911579, PMID:16488887,$#ENSG00000101076#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019$#ENSG00000101076#GO:0004879#ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity#IEA - GO_REF:0000002 $#ENSP00000312987#ENSG00000101076#ENST00000316099#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000315180#ENSG00000101076#ENST00000316673#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000412111#ENSG00000101076#ENST00000415691#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000410911#ENSG00000101076#ENST00000443598#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000396216#ENSG00000101076#ENST00000457232#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000476310#ENSG00000101076#ENST00000609262#Nuclear Hormone Receptor#$#ENSP00000476609#ENSG00000101076#ENST00000609795#Nuclear Hormone Receptor#Hormone_recep FALSE 1600 ENSG00000164749 HNF4G Nuclear receptor Yes Known motif Monomer or homomultimer In vivo/Misc source None None IPR000536;IPR001628;IPR001723;IPR003068;IPR008946; 3174 hepatocyte nuclear factor 4 gamma [Source:HGNC Symbol;Acc:HGNC:5026] None DBD and Full not tested None ChIP-seq model in Jaspar has similar consensus to HNF4A a Yes No Yes 1a1, Direct HQ evidence Pratyush Das Laura Campitelli Yes $#ENSG00000164749#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:8622695$#ENSG00000164749#GO:0004879#ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity#IEA - GO_REF:0000002 $#ENSP00000346339#ENSG00000164749#ENST00000354370#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000379701#ENSG00000164749#ENST00000396423#Nuclear Hormone Receptor#Hormone_recep FALSE 1601 ENSG00000126368 NR1D1 Nuclear receptor Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000536;IPR001628;IPR001723;IPR008946 9572 nuclear receptor subfamily 1 group D member 1 [Source:HGNC Symbol;Acc:HGNC:7962] 1A6Y DBD and Full Yes None Structure is homodimer a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:12021280;12150932 Yes 1a1, Direct HQ evidence Tim Hughes Matt Weirauch Yes $#ENSG00000126368#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:8622974$#ENSG00000126368#GO:0004879#ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity#TAS - PMID:8622974 $#ENSP00000246672#ENSG00000126368#ENST00000246672#Nuclear Hormone Receptor#Hormone_recep FALSE 1602 ENSG00000174738 NR1D2 Nuclear receptor Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000536;IPR001628;IPR001723;IPR008946 9975 nuclear receptor subfamily 1 group D member 2 [Source:HGNC Symbol;Acc:HGNC:7963] None DBD and Full not tested None None a Yes TF Gene Candidate_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:7838156 No 1a1, Direct HQ evidence Jussi Taipale Matt Weirauch Yes $#ENSG00000174738#GO:0004879#ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity#TAS - PMID:7997240 $#ENSP00000310006#ENSG00000174738#ENST00000312521#Nuclear Hormone Receptor#Hormone_recep FALSE 1603 ENSG00000131408 NR1H2 Nuclear receptor Yes Known motif Obligate heteromer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain Likely an obligate heteromer (PMID: 7935418; PMID: 7892230; PMID: 7744246) IPR000536;IPR001628;IPR001723;IPR008946;IPR023257; 7376 nuclear receptor subfamily 1 group H member 2 [Source:HGNC Symbol;Acc:HGNC:7965] 4NQA DBD and Full not tested None Structure is RXRA-NR1H2 heterodimer, with both the LBDs and DBDs a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:16007255;17218271 Yes 1a1, Direct HQ evidence Sam Lambert Matt Weirauch Yes $#ENSG00000131408#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:9013544$#ENSG00000131408#GO:0001133#sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor#IEA - GO_REF:0000019$#ENSG00000131408#GO:0004879#ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity#IEA - GO_REF:0000019 $#ENSP00000253727#ENSG00000131408#ENST00000253727#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000396151#ENSG00000131408#ENST00000411902#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000469778#ENSG00000131408#ENST00000597157#Nuclear Hormone Receptor#$#ENSP00000470518#ENSG00000131408#ENST00000597790#Nuclear Hormone Receptor#$#ENSP00000472138#ENSG00000131408#ENST00000597130#Nuclear Hormone Receptor#$#ENSP00000473099#ENSG00000131408#ENST00000600355#Nuclear Hormone Receptor# FALSE 1604 ENSG00000025434 NR1H3 Nuclear receptor Yes Inferred motif Obligate heteromer In vivo/Misc source None Binds as an obligate heterodimer with RXR-proteins. (PDB: 2ACL) is a crystal structure of the two proteins without DNA IPR000536;IPR001628;IPR001723;IPR008946;IPR023257; 10062 nuclear receptor subfamily 1 group H member 3 [Source:HGNC Symbol;Acc:HGNC:7966] None DBD and Full Yes None Pmid:21349840 Heterodimerizes with RXRA a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:9013544 Yes 1a2, Orthologous HQ evidence Jussi Taipale Arttu Jolma Yes $#ENSG00000025434#GO:0004879#ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity#TAS - PMID:7744246 $#ENSP00000378793#ENSG00000025434#ENST00000395397#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000384745#ENSG00000025434#ENST00000405853#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000387946#ENSG00000025434#ENST00000441012#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000420656#ENSG00000025434#ENST00000467728#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000432073#ENSG00000025434#ENST00000527949#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000403798#ENSG00000025434#ENST00000436778#Nuclear Hormone Receptor#$#ENSP00000396132#ENSG00000025434#ENST00000437276#Nuclear Hormone Receptor#$#ENSP00000391005#ENSG00000025434#ENST00000444396#Nuclear Hormone Receptor#$#ENSP00000434650#ENSG00000025434#ENST00000531660#Nuclear Hormone Receptor#Hormone_recep FALSE 1605 ENSG00000012504 NR1H4 Nuclear receptor Yes Known motif Monomer or homomultimer High-throughput in vitro None Also binds DNA as heterodimer with RXRA (PMID: 11870371) IPR000536;IPR001628;IPR001723;IPR001728;IPR008946; 9971 nuclear receptor subfamily 1 group H member 4 [Source:HGNC Symbol;Acc:HGNC:7967] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific; Transcription Factor Binding: tf co-factor binding_Co-activation_PMIDS:11533040 Yes 2a1, Lower confidence direct evidence Arttu Jolma Sam Lambert Yes $#ENSG00000012504#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:24211198$#ENSG00000012504#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:10334992, PMID:9223286$#ENSG00000012504#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#IDA - PMID:21757002$#ENSG00000012504#GO:0004879#ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity#ISS - PMID:21757002$#ENSG00000012504#GO:0004887#thyroid hormone receptor activity#IEA - GO_REF:0000002$#ENSG00000012504#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IEA - GO_REF:0000019 $#ENSP00000188403#ENSG00000012504#ENST00000188403#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000376712#ENSG00000012504#ENST00000392986#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000448506#ENSG00000012504#ENST00000548884#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000448978#ENSG00000012504#ENST00000549996#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000447149#ENSG00000012504#ENST00000551379#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000446760#ENSG00000012504#ENST00000546380#Nuclear Hormone Receptor#$#ENSP00000446861#ENSG00000012504#ENST00000551184#Nuclear Hormone Receptor# FALSE 1606 ENSG00000144852 NR1I2 Nuclear receptor Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000536;IPR001628;IPR001723;IPR001728;IPR008946; 8856 nuclear receptor subfamily 1 group I member 2 [Source:HGNC Symbol;Acc:HGNC:7968] None DBD and Full not tested None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:11114890 No 1a1, Direct HQ evidence Matt Weirauch Arttu Jolma Yes $#ENSG00000144852#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IDA - PMID:11114890$#ENSG00000144852#GO:0004879#ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity#IDA - PMID:12578355 $#ENSP00000336528#ENSG00000144852#ENST00000337940#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000377319#ENSG00000144852#ENST00000393716#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000420297#ENSG00000144852#ENST00000466380#Nuclear Hormone Receptor#Hormone_recep FALSE 1607 ENSG00000143257 NR1I3 Nuclear receptor Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000536;IPR001628;IPR001723;IPR001728;IPR008946; 9970 nuclear receptor subfamily 1 group I member 3 [Source:HGNC Symbol;Acc:HGNC:7969] None DBD and Full not tested None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:8114692;12511605 Yes 1a1, Direct HQ evidence Jussi Taipale Arttu Jolma Yes $#ENSG00000143257#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IDA - PMID:11114890$#ENSG00000143257#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:8020947, PMID:8114692$#ENSG00000143257#GO:0004879#ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity#TAS - PMID:8114692$#ENSG00000143257#GO:0004882#androgen receptor activity#TAS - PMID:9783588$#ENSG00000143257#GO:0004887#thyroid hormone receptor activity#IEA - GO_REF:0000002 $#ENSP00000356958#ENSG00000143257#ENST00000367979#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000356960#ENSG00000143257#ENST00000367981#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000356961#ENSG00000143257#ENST00000367982#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000356962#ENSG00000143257#ENST00000367983#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000356963#ENSG00000143257#ENST00000367984#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000356965#ENSG00000143257#ENST00000367985#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000399361#ENSG00000143257#ENST00000412844#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000412672#ENSG00000143257#ENST00000428574#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000407446#ENSG00000143257#ENST00000437437#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000406493#ENSG00000143257#ENST00000442691#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000421374#ENSG00000143257#ENST00000502985#Nuclear Hormone Receptor#$#ENSP00000424345#ENSG00000143257#ENST00000504010#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000424934#ENSG00000143257#ENST00000505005#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000422982#ENSG00000143257#ENST00000508387#Nuclear Hormone Receptor#$#ENSP00000423666#ENSG00000143257#ENST00000508740#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000427175#ENSG00000143257#ENST00000511676#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000427600#ENSG00000143257#ENST00000511748#Nuclear Hormone Receptor#$#ENSP00000426292#ENSG00000143257#ENST00000511944#Nuclear Hormone Receptor#$#ENSP00000425417#ENSG00000143257#ENST00000512372#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000421588#ENSG00000143257#ENST00000515621#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000423089#ENSG00000143257#ENST00000506209#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000427034#ENSG00000143257#ENST00000515452#Nuclear Hormone Receptor#Hormone_recep FALSE 1608 ENSG00000120798 NR2C1 Nuclear receptor Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000536;IPR001628;IPR001723;IPR008946 7181 nuclear receptor subfamily 2 group C member 1 [Source:HGNC Symbol;Acc:HGNC:7971] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:12849971 No 1a1, Direct HQ evidence Yimeng Yin Pratyush Das Yes $#ENSG00000120798#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019 $#ENSP00000376813#ENSG00000120798#ENST00000393101#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000333275#ENSG00000120798#ENST00000333003#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000446906#ENSG00000120798#ENST00000547469#Nuclear Hormone Receptor# FALSE 1609 ENSG00000177463 NR2C2 Nuclear receptor Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000536;IPR001628;IPR001723;IPR008946 7182 nuclear receptor subfamily 2 group C member 2 [Source:HGNC Symbol;Acc:HGNC:7972] None DBD and Full not tested None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:9006963 Yes 1a1, Direct HQ evidence Arttu Jolma Pratyush Das Yes $#ENSG00000177463#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:10644740 $#ENSP00000320447#ENSG00000177463#ENST00000323373#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000384463#ENSG00000177463#ENST00000406272#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000483059#ENSG00000177463#ENST00000617312#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000388387#ENSG00000177463#ENST00000425241#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000413438#ENSG00000177463#ENST00000413194#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000391473#ENSG00000177463#ENST00000435454#Nuclear Hormone Receptor#$#ENSP00000401807#ENSG00000177463#ENST00000437120#Nuclear Hormone Receptor#$#ENSP00000412473#ENSG00000177463#ENST00000439011#Nuclear Hormone Receptor#Hormone_recep FALSE 1610 ENSG00000112333 NR2E1 Nuclear receptor Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000536;IPR001628;IPR001723;IPR008946 7101 nuclear receptor subfamily 2 group E member 1 [Source:HGNC Symbol;Acc:HGNC:7973] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:8047143;11073974 No 1a1, Direct HQ evidence Yimeng Yin Sam Lambert Yes $#ENSG00000112333#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000112333#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019 $#ENSP00000357982#ENSG00000112333#ENST00000368986#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000357979#ENSG00000112333#ENST00000368983#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000416908#ENSG00000112333#ENST00000426403#Nuclear Hormone Receptor# FALSE 1611 ENSG00000278570 NR2E3 Nuclear receptor Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001723;IPR001628;IPR000536;IPR013088 10002 Nuclear receptor subfamily 2 group E member 3 [Source:HGNC Symbol;Acc:HGNC:7974] None DBD and Full Yes None None a Yes TF Gene_Transcription Factor Binding: tf co-factor binding_Co-activation_PMIDS:15689355 Yes 2a1, Lower confidence direct evidence Laura Campitelli Jussi Taipale Yes $#ENSG00000278570#GO:0004879#ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity#TAS - PMID:10220376 $#ENSP00000482504#ENSG00000278570#ENST00000617575#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000479962#ENSG00000278570#ENST00000621098#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000479254#ENSG00000278570#ENST00000621736#Nuclear Hormone Receptor#Hormone_recep FALSE 1612 ENSG00000175745 NR2F1 Nuclear receptor Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000536;IPR001628;IPR001723;IPR003068;IPR008946; 7025 nuclear receptor subfamily 2 group F member 1 [Source:HGNC Symbol;Acc:HGNC:7975] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:2739739;17009409 Yes 1a1, Direct HQ evidence Pratyush Das Arttu Jolma Yes $#ENSG00000175745#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:10644740$#ENSG00000175745#GO:0004879#ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity#IEA - GO_REF:0000002 $#ENSP00000325819#ENSG00000175745#ENST00000327111#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000481517#ENSG00000175745#ENST00000615873#Nuclear Hormone Receptor#Hormone_recep FALSE 1613 ENSG00000185551 NR2F2 Nuclear receptor Yes Known motif Monomer or homomultimer 100 perc ID - in vitro None None IPR000536;IPR001628;IPR001723;IPR003068;IPR008946; 100302258 nuclear receptor subfamily 2 group F member 2 [Source:HGNC Symbol;Acc:HGNC:7976] None DBD Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:8622679 Yes 1a1, Direct HQ evidence Pratyush Das Sam Lambert Yes $#ENSG00000185551#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:9343308$#ENSG00000185551#GO:0004879#ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity#IDA - PMID:18798693 $#ENSP00000377721#ENSG00000185551#ENST00000394166#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000401674#ENSG00000185551#ENST00000421109#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000389853#ENSG00000185551#ENST00000453270#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000377726#ENSG00000185551#ENST00000394171#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000457112#ENSG00000185551#ENST00000559679#Nuclear Hormone Receptor#Hormone_recep FALSE 1614 ENSG00000160113 NR2F6 Nuclear receptor Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000536;IPR001628;IPR001723;IPR003068;IPR008946; 2063 nuclear receptor subfamily 2 group F member 6 [Source:HGNC Symbol;Acc:HGNC:7977] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:12690040 Yes 1a1, Direct HQ evidence Laura Campitelli Arttu Jolma Yes $#ENSG00000160113#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IEA - GO_REF:0000019$#ENSG00000160113#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:10644740$#ENSG00000160113#GO:0004879#ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity#TAS - PMID:2905047$#ENSG00000160113#GO:0004887#thyroid hormone receptor activity#TAS - PMID:2905047 $#ENSP00000291442#ENSG00000160113#ENST00000291442#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000471686#ENSG00000160113#ENST00000596878#Nuclear Hormone Receptor#Hormone_recep FALSE 1615 ENSG00000113580 NR3C1 Nuclear receptor Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000536;IPR001409;IPR001628;IPR001723;IPR008946; 2908 nuclear receptor subfamily 3 group C member 1 [Source:HGNC Symbol;Acc:HGNC:7978] 1GLU DBD and Full not tested None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:16728402;67253380;15563547 Yes 1a1, Direct HQ evidence Jussi Taipale Sam Lambert Yes $#ENSG00000113580#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:16728402, PMID:23823477$#ENSG00000113580#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:15769988, PMID:17635946 $#ENSP00000231509#ENSG00000113580#ENST00000231509#Nuclear Hormone Receptor#GCR, Hormone_recep$#ENSP00000377977#ENSG00000113580#ENST00000394464#Nuclear Hormone Receptor#GCR, Hormone_recep$#ENSP00000387672#ENSG00000113580#ENST00000415690#Nuclear Hormone Receptor#GCR, Hormone_recep$#ENSP00000405282#ENSG00000113580#ENST00000424646#Nuclear Hormone Receptor#GCR, Hormone_recep$#ENSP00000420856#ENSG00000113580#ENST00000502892#Nuclear Hormone Receptor#GCR$#ENSP00000427672#ENSG00000113580#ENST00000503201#Nuclear Hormone Receptor#GCR, Hormone_recep$#ENSP00000422518#ENSG00000113580#ENST00000504572#Nuclear Hormone Receptor#GCR, Hormone_recep$#ENSP00000425313#ENSG00000113580#ENST00000508760#Nuclear Hormone Receptor#GCR$#ENSP00000424747#ENSG00000113580#ENST00000510170#Nuclear Hormone Receptor#GCR$#ENSP00000426478#ENSG00000113580#ENST00000514699#Nuclear Hormone Receptor#GCR FALSE 1616 ENSG00000151623 NR3C2 Nuclear receptor Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000536;IPR001628;IPR008946; 4306 nuclear receptor subfamily 3 group C member 2 [Source:HGNC Symbol;Acc:HGNC:7979] 4TNT DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_Transactivation_PMIDS:3037703;8389140 No 1a1, Direct HQ evidence Arttu Jolma Matt Weirauch Yes $#ENSG00000151623#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002 $#ENSP00000350815#ENSG00000151623#ENST00000358102#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000423510#ENSG00000151623#ENST00000512865#Nuclear Hormone Receptor# FALSE 1617 ENSG00000123358 NR4A1 Nuclear receptor Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000536;IPR001628;IPR001723;IPR003070;IPR003071;IPR008946 3164 nuclear receptor subfamily 4 group A member 1 [Source:HGNC Symbol;Acc:HGNC:7980] 1CIT DBD and Full not tested None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:16237153 Yes 1a1, Direct HQ evidence Jussi Taipale Laura Campitelli Yes $#ENSG00000123358#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#ISS - GO_REF:0000024$#ENSG00000123358#GO:0004879#ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity#IEA - GO_REF:0000002 $#ENSP00000243050#ENSG00000123358#ENST00000243050#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000378302#ENSG00000123358#ENST00000394825#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000449587#ENSG00000123358#ENST00000548232#Nuclear Hormone Receptor#$#ENSP00000353427#ENSG00000123358#ENST00000360284#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000440864#ENSG00000123358#ENST00000545748#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000457070#ENSG00000123358#ENST00000546842#Nuclear Hormone Receptor#$#ENSP00000456633#ENSG00000123358#ENST00000548977#Nuclear Hormone Receptor#$#ENSP00000456776#ENSG00000123358#ENST00000553200#Nuclear Hormone Receptor#$#ENSP00000455399#ENSG00000123358#ENST00000562373#Nuclear Hormone Receptor# FALSE 1618 ENSG00000153234 NR4A2 Nuclear receptor Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000536;IPR001628;IPR001723;IPR003070;IPR003073;IPR008946 4929 nuclear receptor subfamily 4 group A member 2 [Source:HGNC Symbol;Acc:HGNC:7981] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_Co-activation; DNA Binding; Transactivation_PMIDS:12122012;15485875 Yes 1a1, Direct HQ evidence Arttu Jolma Jussi Taipale Yes $#ENSG00000153234#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#ISS - GO_REF:0000024$#ENSG00000153234#GO:0004879#ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity#TAS - PMID:16243425 $#ENSP00000344479#ENSG00000153234#ENST00000339562#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000406808#ENSG00000153234#ENST00000424077#Nuclear Hormone Receptor#$#ENSP00000389986#ENSG00000153234#ENST00000426264#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000385379#ENSG00000153234#ENST00000406048#Nuclear Hormone Receptor# FALSE 1619 ENSG00000119508 NR4A3 Nuclear receptor Yes Known motif Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain None IPR000536;IPR001628;IPR001723;IPR003070;IPR003072;IPR008946 8013 nuclear receptor subfamily 4 group A member 3 [Source:HGNC Symbol;Acc:HGNC:7982] None DBD not tested None Taipale lab has an unpublished PWM that looks just like other NR4A TFs a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:10875239 Yes 1a1, Direct HQ evidence Matt Weirauch Tim Hughes Yes $#ENSG00000119508#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:20558821$#ENSG00000119508#GO:0004887#thyroid hormone receptor activity#TAS - PMID:8570200 $#ENSP00000340301#ENSG00000119508#ENST00000338488#Nuclear Hormone Receptor#$#ENSP00000378531#ENSG00000119508#ENST00000395097#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000333122#ENSG00000119508#ENST00000330847#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000482027#ENSG00000119508#ENST00000618101#Nuclear Hormone Receptor#Hormone_recep FALSE 1620 ENSG00000136931 NR5A1 Nuclear receptor Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000536;IPR001628;IPR001723;IPR008946;IPR016355; 2516 nuclear receptor subfamily 5 group A member 1 [Source:HGNC Symbol;Acc:HGNC:7983] 2FF0 DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_Other_PMIDS:8463279;10913126 Yes 1a1, Direct HQ evidence Yimeng Yin Matt Weirauch Yes $#ENSG00000136931#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#IDA - PMID:21412441$#ENSG00000136931#GO:0004879#ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity#TAS - PMID:8205615 $#ENSP00000362690#ENSG00000136931#ENST00000373588#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000362689#ENSG00000136931#ENST00000373587#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000393245#ENSG00000136931#ENST00000455734#Nuclear Hormone Receptor#$#ENSP00000483309#ENSG00000136931#ENST00000620110#Nuclear Hormone Receptor#Hormone_recep FALSE 1621 ENSG00000116833 NR5A2 Nuclear receptor Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000536;IPR001628;IPR001723;IPR008946;IPR016355; 2494 nuclear receptor subfamily 5 group A member 2 [Source:HGNC Symbol;Acc:HGNC:7984] 2A66 DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:12456679;15014077 Yes 1a1, Direct HQ evidence Pratyush Das Matt Weirauch Yes $#ENSG00000116833#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000116833#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:15205472, PMID:15723037, PMID:16289203$#ENSG00000116833#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#TAS - PMID:9786908$#ENSG00000116833#GO:0004879#ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity#TAS - PMID:16271724 $#ENSP00000236914#ENSG00000116833#ENST00000236914#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000356326#ENSG00000116833#ENST00000367357#Nuclear Hormone Receptor#$#ENSP00000356331#ENSG00000116833#ENST00000367362#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000414888#ENSG00000116833#ENST00000447034#Nuclear Hormone Receptor#$#ENSP00000439116#ENSG00000116833#ENST00000544748#Nuclear Hormone Receptor#Hormone_recep FALSE 1622 ENSG00000148200 NR6A1 Nuclear receptor Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000536;IPR001628;IPR001723;IPR008946 2649 nuclear receptor subfamily 6 group A member 1 [Source:HGNC Symbol;Acc:HGNC:7985] None DBD not tested None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:9099702;15236322 Yes 1a1, Direct HQ evidence Laura Campitelli Pratyush Das Yes $#ENSG00000148200#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000148200#GO:0004879#ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity#TAS - PMID:9134503 $#ENSP00000362686#ENSG00000148200#ENST00000373584#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000413701#ENSG00000148200#ENST00000416460#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000420267#ENSG00000148200#ENST00000487099#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000420587#ENSG00000148200#ENST00000475178#Nuclear Hormone Receptor# FALSE 1623 ENSG00000082175 PGR Nuclear receptor Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000128;IPR000536;IPR001628;IPR001723;IPR008946; 5241 progesterone receptor [Source:HGNC Symbol;Acc:HGNC:8910] 2C7A DBD Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:5579944;12114521 Yes 1a1, Direct HQ evidence Matt Weirauch Jussi Taipale Yes $#ENSG00000082175#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:17785366 $#ENSP00000263463#ENSG00000082175#ENST00000263463#Nuclear Hormone Receptor#Hormone_recep, Prog_receptor$#ENSP00000325120#ENSG00000082175#ENST00000325455#Nuclear Hormone Receptor#Hormone_recep, Prog_receptor$#ENSP00000436561#ENSG00000082175#ENST00000534013#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000487607#ENSG00000082175#ENST00000632634#Nuclear Hormone Receptor#Prog_receptor FALSE 1624 ENSG00000186951 PPARA Nuclear receptor Yes Known motif Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain None IPR000536;IPR001628;IPR001723;IPR003074;IPR003076;IPR008946 5465 peroxisome proliferator activated receptor alpha [Source:HGNC Symbol;Acc:HGNC:9232] None DBD and Full Yes Obligate_Multimer Heterodimerizes with RXR TFs a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:1537328;8123021;8386511;12847522;9748239 Yes 2a1, Lower confidence direct evidence Yimeng Yin Pratyush Das Yes $#ENSG00000186951#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:9748239$#ENSG00000186951#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:9748239$#ENSG00000186951#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:19955185 | ISS - GO_REF:0000024$#ENSG00000186951#GO:0004879#ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity#IDA - PMID:12955147, PMID:19955185 $#ENSP00000385246#ENSG00000186951#ENST00000402126#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000385523#ENSG00000186951#ENST00000407236#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000397291#ENSG00000186951#ENST00000440343#Nuclear Hormone Receptor#$#ENSP00000414752#ENSG00000186951#ENST00000420804#Nuclear Hormone Receptor# FALSE 1625 ENSG00000112033 PPARD Nuclear receptor Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000536;IPR001628;IPR001723;IPR003074;IPR003075;IPR008946 5467 peroxisome proliferator activated receptor delta [Source:HGNC Symbol;Acc:HGNC:9235] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_Other_PMIDS:11923467 Yes 1a1, Direct HQ evidence Matt Weirauch Sam Lambert Yes $#ENSG00000112033#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#ISS - GO_REF:0000024$#ENSG00000112033#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:12955147 | NAS - PMID:11551955$#ENSG00000112033#GO:0004879#ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity#IDA - PMID:12955147 $#ENSP00000353916#ENSG00000112033#ENST00000360694#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000413314#ENSG00000112033#ENST00000418635#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000414372#ENSG00000112033#ENST00000448077#Nuclear Hormone Receptor#Hormone_recep FALSE 1626 ENSG00000132170 PPARG Nuclear receptor Yes Known motif Monomer or homomultimer 100 perc ID - in vitro None Also heterodimerizes. IPR000536;IPR001628;IPR001723;IPR003074;IPR003077;IPR008946;IPR022590; 5468 peroxisome proliferator activated receptor gamma [Source:HGNC Symbol;Acc:HGNC:9236] 3DZU DBD and Full Yes Obligate_Multimer Heterodimerizes with RXR TFs; crystal is PPARG-RXRA heterodimer; jaspar model is heterodimer of PPARG with RXRA a Yes TF Gene_DNA-Binding: sequence-specific_Transactivation_PMIDS:14744933;15681609 Yes 1a1, Direct HQ evidence Jussi Taipale Pratyush Das Yes $#ENSG00000132170#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:9568715 | ISS - GO_REF:0000024$#ENSG00000132170#GO:0004879#ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity#IDA - PMID:10622252$#ENSG00000132170#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:18293083 $#ENSP00000287820#ENSG00000132170#ENST00000287820#Nuclear Hormone Receptor#Hormone_recep, PPARgamma_N$#ENSP00000380196#ENSG00000132170#ENST00000397000#Nuclear Hormone Receptor#PPARgamma_N$#ENSP00000380205#ENSG00000132170#ENST00000397010#Nuclear Hormone Receptor#Hormone_recep, PPARgamma_N$#ENSP00000380207#ENSG00000132170#ENST00000397012#Nuclear Hormone Receptor#Hormone_recep, PPARgamma_N$#ENSP00000380210#ENSG00000132170#ENST00000397015#Nuclear Hormone Receptor#Hormone_recep, PPARgamma_N$#ENSP00000411931#ENSG00000132170#ENST00000455517#Nuclear Hormone Receptor#PPARgamma_N$#ENSP00000312472#ENSG00000132170#ENST00000309576#Nuclear Hormone Receptor#Hormone_recep, PPARgamma_N$#ENSP00000380224#ENSG00000132170#ENST00000397029#Nuclear Hormone Receptor#PPARgamma_N$#ENSP00000392285#ENSG00000132170#ENST00000438682#Nuclear Hormone Receptor#PPARgamma_N FALSE 1627 ENSG00000131759 RARA Nuclear receptor Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000536;IPR001628;IPR001723;IPR003078;IPR008946; 5914 retinoic acid receptor alpha [Source:HGNC Symbol;Acc:HGNC:9864] 1DSZ DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:1312934 Yes 1a1, Direct HQ evidence Sam Lambert Jussi Taipale Yes $#ENSG00000131759#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:18922886, PMID:20413580$#ENSG00000131759#GO:0003708#retinoic acid receptor activity#IDA - PMID:2825025 $#ENSP00000254066#ENSG00000131759#ENST00000254066#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000377643#ENSG00000131759#ENST00000394081#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000389993#ENSG00000131759#ENST00000425707#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000377648#ENSG00000131759#ENST00000394086#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000377649#ENSG00000131759#ENST00000394089#Nuclear Hormone Receptor#Hormone_recep FALSE 1628 ENSG00000077092 RARB Nuclear receptor Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000536;IPR001628;IPR001723;IPR003078;IPR008946; 5915 retinoic acid receptor beta [Source:HGNC Symbol;Acc:HGNC:9865] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:2153268 No 1a1, Direct HQ evidence Jussi Taipale Tim Hughes Yes $#ENSG00000077092#GO:0003708#retinoic acid receptor activity#IEA - GO_REF:0000019 $#ENSP00000332296#ENSG00000077092#ENST00000330688#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000398840#ENSG00000077092#ENST00000437042#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000391391#ENSG00000077092#ENST00000458646#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000373282#ENSG00000077092#ENST00000383772#Nuclear Hormone Receptor#Hormone_recep FALSE 1629 ENSG00000172819 RARG Nuclear receptor Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000536;IPR001628;IPR001723;IPR003078;IPR008946; 5916 retinoic acid receptor gamma [Source:HGNC Symbol;Acc:HGNC:9866] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:2544807;15327771 Yes 1a1, Direct HQ evidence Jussi Taipale Arttu Jolma Yes $#ENSG00000172819#GO:0003700#sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024$#ENSG00000172819#GO:0003708#retinoic acid receptor activity#IEA - GO_REF:0000019 $#ENSP00000343698#ENSG00000172819#ENST00000338561#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000377947#ENSG00000172819#ENST00000394426#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000388510#ENSG00000172819#ENST00000425354#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000444335#ENSG00000172819#ENST00000543726#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000454385#ENSG00000172819#ENST00000550362#Nuclear Hormone Receptor#$#ENSP00000454604#ENSG00000172819#ENST00000551158#Nuclear Hormone Receptor# FALSE 1630 ENSG00000069667 RORA Nuclear receptor Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000536;IPR001628;IPR001723;IPR003079;IPR008946; 6095 RAR related orphan receptor A [Source:HGNC Symbol;Acc:HGNC:10258] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:7926749;7926749;15941850;15821743;7926749;12467577 Yes 1a1, Direct HQ evidence Sam Lambert Arttu Jolma Yes $#ENSG00000069667#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:11053433, PMID:17545671, PMID:18658046,$#ENSG00000069667#GO:0004879#ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity#IEA - GO_REF:0000002$#ENSG00000069667#GO:0098531#transcription factor activity, direct ligand regulated sequence-specific DNA binding#IDA - PMID:19965867 $#ENSP00000261523#ENSG00000069667#ENST00000261523#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000309753#ENSG00000069667#ENST00000309157#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000335087#ENSG00000069667#ENST00000335670#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000402971#ENSG00000069667#ENST00000449337#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000484955#ENSG00000069667#ENST00000558904#Nuclear Hormone Receptor# FALSE 1631 ENSG00000198963 RORB Nuclear receptor Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000536;IPR001628;IPR001723;IPR003079;IPR008946; 6096 RAR related orphan receptor B [Source:HGNC Symbol;Acc:HGNC:10259] None DBD Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:7935491 Yes 1a1, Direct HQ evidence Yimeng Yin Laura Campitelli Yes $#ENSG00000198963#GO:0003700#sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024$#ENSG00000198963#GO:0004879#ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity#IEA - GO_REF:0000002 $#ENSP00000366093#ENSG00000198963#ENST00000376896#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000379507#ENSG00000198963#ENST00000396204#Nuclear Hormone Receptor#Hormone_recep FALSE 1632 ENSG00000143365 RORC Nuclear receptor Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000536;IPR001628;IPR001723;IPR003079;IPR008946; 6097 RAR related orphan receptor C [Source:HGNC Symbol;Acc:HGNC:10260] None DBD and Full not tested None None a Yes Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0 Yes 1a1, Direct HQ evidence Arttu Jolma Sam Lambert Yes $#ENSG00000143365#GO:0003700#sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024$#ENSG00000143365#GO:0004879#ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity#IEA - GO_REF:0000002$#ENSG00000143365#GO:0098531#transcription factor activity, direct ligand regulated sequence-specific DNA binding#IDA - PMID:19965867 $#ENSP00000327025#ENSG00000143365#ENST00000318247#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000349164#ENSG00000143365#ENST00000356728#Nuclear Hormone Receptor#Hormone_recep FALSE 1633 ENSG00000186350 RXRA Nuclear receptor Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000003;IPR000536;IPR001628;IPR001723;IPR008946;IPR021780 6256 retinoid X receptor alpha [Source:HGNC Symbol;Acc:HGNC:10477] 1BY4 DBD and Full Yes None None a Yes TF Gene_Transcription Factor Binding: tf co-factor binding; DNA-Binding: sequence-specific_DNA Binding; TF PPI_PMIDS:7838715;15544927 Yes 1a1, Direct HQ evidence Pratyush Das Arttu Jolma Yes $#ENSG00000186350#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:12037571, PMID:17426122, PMID:20219900$#ENSG00000186350#GO:0003708#retinoic acid receptor activity#TAS - PMID:19374686$#ENSG00000186350#GO:0004879#ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity#IDA - PMID:7990953$#ENSG00000186350#GO:0004886#9-cis retinoic acid receptor activity#IEA - GO_REF:0000019 $#ENSP00000419692#ENSG00000186350#ENST00000481739#Nuclear Hormone Receptor#Hormone_recep, Nuc_recep-AF1 FALSE 1634 ENSG00000204231 RXRB Nuclear receptor Yes Known motif Monomer or homomultimer High-throughput in vitro None Has been shown to bind both as a homodimer and with several nuclear receptor homodimerization partners IPR000003;IPR000536;IPR001628;IPR001723;IPR008946; 6257 retinoid X receptor beta [Source:HGNC Symbol;Acc:HGNC:10478] None DBD and Full Yes None None a Yes TF Gene Candidate_DNA-Binding: sequence-specific_DNA Binding_PMIDS:2554307;10393558 No 1a1, Direct HQ evidence Arttu Jolma Pratyush Das Yes $#ENSG00000204231#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IDA - PMID:12767074$#ENSG00000204231#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:1662118$#ENSG00000204231#GO:0004879#ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity#IDA - PMID:7990953$#ENSG00000204231#GO:0004886#9-cis retinoic acid receptor activity#TAS - PMID:1662118 $#ENSP00000363812#ENSG00000204231#ENST00000374680#Nuclear Hormone Receptor#Hormone_recep, Nuc_recep-AF1$#ENSP00000363817#ENSG00000204231#ENST00000374685#Nuclear Hormone Receptor#Hormone_recep, Nuc_recep-AF1 FALSE 1635 ENSG00000143171 RXRG Nuclear receptor Yes Known motif Monomer or homomultimer High-throughput in vitro None Usually binds in vivo as a heterodimer, but can bind as a homodimer in vitro IPR000003;IPR000536;IPR001628;IPR001723;IPR008946;IPR021780 6258 retinoid X receptor gamma [Source:HGNC Symbol;Acc:HGNC:10479] None DBD and Full Yes None None a Yes Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0 Yes 1a1, Direct HQ evidence Jussi Taipale Sam Lambert Yes $#ENSG00000143171#GO:0004886#9-cis retinoic acid receptor activity#IEA - GO_REF:0000019 $#ENSP00000352900#ENSG00000143171#ENST00000359842#Nuclear Hormone Receptor#Hormone_recep, Nuc_recep-AF1$#ENSP00000482458#ENSG00000143171#ENST00000619224#Nuclear Hormone Receptor#Hormone_recep FALSE 1636 ENSG00000126351 THRA Nuclear receptor Yes Known motif Monomer or homomultimer High-throughput in vitro None Likely binds as a heterodimer too IPR000536;IPR001628;IPR001723;IPR001728;IPR008946; 7067 thyroid hormone receptor, alpha [Source:HGNC Symbol;Acc:HGNC:11796] None DBD and Full not tested None None a Yes TF Gene_DNA-Binding: sequence-specific_Co-activation; DNA Binding_PMIDS:8559662;11773435 Yes 1a1, Direct HQ evidence Sam Lambert Tim Hughes Yes $#ENSG00000126351#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:18052923, PMID:8710870, PMID:9653119$#ENSG00000126351#GO:0004887#thyroid hormone receptor activity#IDA - PMID:15466465, PMID:18052923, PMID:8710870 $#ENSP00000264637#ENSG00000126351#ENST00000264637#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000395641#ENSG00000126351#ENST00000450525#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000463466#ENSG00000126351#ENST00000584985#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000377679#ENSG00000126351#ENST00000394121#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000443972#ENSG00000126351#ENST00000546243#Nuclear Hormone Receptor#Hormone_recep FALSE 1637 ENSG00000151090 THRB Nuclear receptor Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000536;IPR001628;IPR001723;IPR001728;IPR008946; 7068 thyroid hormone receptor beta [Source:HGNC Symbol;Acc:HGNC:11799] None DBD and Full not tested None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:1648450;1648451 Yes 1a1, Direct HQ evidence Yimeng Yin Sam Lambert Yes $#ENSG00000151090#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:1618799$#ENSG00000151090#GO:0004887#thyroid hormone receptor activity#IDA - PMID:15466465 $#ENSP00000348827#ENSG00000151090#ENST00000356447#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000404898#ENSG00000151090#ENST00000415021#Nuclear Hormone Receptor#$#ENSP00000395362#ENSG00000151090#ENST00000431815#Nuclear Hormone Receptor#$#ENSP00000388467#ENSG00000151090#ENST00000447875#Nuclear Hormone Receptor#$#ENSP00000414910#ENSG00000151090#ENST00000453729#Nuclear Hormone Receptor#$#ENSP00000414444#ENSG00000151090#ENST00000416420#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000393932#ENSG00000151090#ENST00000418247#Nuclear Hormone Receptor#$#ENSP00000414100#ENSG00000151090#ENST00000413780#Nuclear Hormone Receptor# FALSE 1638 ENSG00000111424 VDR Nuclear receptor Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000324;IPR000536;IPR001628;IPR001723;IPR008946; 7421 vitamin D (1,25- dihydroxyvitamin D3) receptor [Source:HGNC Symbol;Acc:HGNC:12679] 1KB2 DBD and Full Yes None None a Yes TF Gene Candidate_DNA-Binding: sequence-specific; Transcription Factor Binding: tf co-factor binding_Co-activation; DNA Binding_PMIDS:16750418;8674817 Yes 1a1, Direct HQ evidence Laura Campitelli Tim Hughes Yes $#ENSG00000111424#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:17426122$#ENSG00000111424#GO:0008434#vitamin D3 receptor activity#IDA - PMID:12016314, PMID:16549446, PMID:17082781 $#ENSP00000449573#ENSG00000111424#ENST00000549336#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000447173#ENSG00000111424#ENST00000550325#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000449561#ENSG00000111424#ENST00000550314#Nuclear Hormone Receptor# FALSE 1639 ENSG00000141510 TP53 p53 Yes Known motif Monomer or homomultimer In vivo/Misc source None None IPR002117;IPR008967;IPR010991;IPR011615;IPR013872; 7157 tumor protein p53 [Source:HGNC Symbol;Acc:HGNC:11998] 1TSR DBD and Full not tested None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:12082536 Yes 1a1, Direct HQ evidence Matt Weirauch Yimeng Yin Yes $#ENSG00000141510#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IDA - PMID:24652652$#ENSG00000141510#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IDA - PMID:17146433$#ENSG00000141510#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:18549481, PMID:7587074 $#ENSP00000269305#ENSG00000141510#ENST00000269305#p53#P53_TAD, P53_tetramer$#ENSP00000352610#ENSG00000141510#ENST00000359597#p53#P53_TAD$#ENSP00000410739#ENSG00000141510#ENST00000413465#p53#P53_TAD$#ENSP00000391127#ENSG00000141510#ENST00000420246#p53#P53_TAD$#ENSP00000391478#ENSG00000141510#ENST00000445888#p53#P53_TAD, P53_tetramer$#ENSP00000398846#ENSG00000141510#ENST00000455263#p53#P53_TAD$#ENSP00000484409#ENSG00000141510#ENST00000504290#p53#$#ENSP00000481179#ENSG00000141510#ENST00000504937#p53#P53_tetramer$#ENSP00000478499#ENSG00000141510#ENST00000510385#p53#$#ENSP00000423862#ENSG00000141510#ENST00000514944#p53#P53_TAD$#ENSP00000458393#ENSG00000141510#ENST00000576024#p53#$#ENSP00000478219#ENSG00000141510#ENST00000610292#p53#P53_tetramer$#ENSP00000480868#ENSG00000141510#ENST00000610538#p53#$#ENSP00000477531#ENSG00000141510#ENST00000610623#p53#$#ENSP00000482258#ENSG00000141510#ENST00000617185#p53#P53_TAD$#ENSP00000481401#ENSG00000141510#ENST00000618944#p53#$#ENSP00000484375#ENSG00000141510#ENST00000619186#p53#P53_tetramer$#ENSP00000482537#ENSG00000141510#ENST00000619485#p53#P53_tetramer$#ENSP00000481638#ENSG00000141510#ENST00000620739#p53#P53_tetramer$#ENSP00000482222#ENSG00000141510#ENST00000622645#p53# FALSE 1640 ENSG00000073282 TP63 p53 Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001660;IPR002117;IPR008967;IPR010991;IPR011510;IPR011615;IPR013761; 8626 tumor protein p63 [Source:HGNC Symbol;Acc:HGNC:15979] 3QYM DBD and Full not tested None None a Yes TF Gene Candidate__Transactivation_PMIDS:9774969 Yes 1a1, Direct HQ evidence Matt Weirauch Jussi Taipale Yes $#ENSG00000073282#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000073282#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000264731#ENSG00000073282#ENST00000264731#p53#P53_tetramer, SAM_2$#ENSP00000317510#ENSG00000073282#ENST00000320472#p53#P53_tetramer$#ENSP00000346614#ENSG00000073282#ENST00000354600#p53#P53_tetramer, SAM_2$#ENSP00000376254#ENSG00000073282#ENST00000392461#p53#P53_tetramer$#ENSP00000376256#ENSG00000073282#ENST00000392463#p53#P53_tetramer$#ENSP00000407144#ENSG00000073282#ENST00000418709#p53#P53_tetramer$#ENSP00000392488#ENSG00000073282#ENST00000437221#p53#P53_tetramer$#ENSP00000387839#ENSG00000073282#ENST00000449992#p53#P53_tetramer, SAM_2 FALSE 1641 ENSG00000078900 TP73 p53 Yes Known motif Monomer or homomultimer In vivo/Misc source None None IPR001660;IPR002117;IPR008967;IPR010991;IPR011510;IPR011615;IPR013761; 7161 tumor protein p73 [Source:HGNC Symbol;Acc:HGNC:12003] 3VD0 DBD and Full not tested None None a Yes Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0 Yes 1a1, Direct HQ evidence Matt Weirauch Pratyush Das Yes $#ENSG00000078900#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IDA - PMID:24652652$#ENSG00000078900#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:16343436$#ENSG00000078900#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:15678106 $#ENSP00000367529#ENSG00000078900#ENST00000378280#p53#P53_tetramer$#ENSP00000367534#ENSG00000078900#ENST00000378285#p53#P53_tetramer$#ENSP00000367537#ENSG00000078900#ENST00000378288#p53#P53_tetramer, SAM_1, SAM_2$#ENSP00000367545#ENSG00000078900#ENST00000378295#p53#P53_tetramer, SAM_1, SAM_2$#ENSP00000367539#ENSG00000078900#ENST00000378290#p53#P53_tetramer, SAM_1, SAM_2 FALSE 1642 ENSG00000125813 PAX1 Paired box Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001523;IPR009057 5075 paired box 1 [Source:HGNC Symbol;Acc:HGNC:8615] None DBD not tested None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:12490554 No 1a1, Direct HQ evidence Laura Campitelli Tim Hughes Yes $#ENSG00000125813#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002 $#ENSP00000481334#ENSG00000125813#ENST00000613128#Paired Box#$#ENSP00000410355#ENSG00000125813#ENST00000444366#Paired Box#$#ENSP00000381499#ENSG00000125813#ENST00000398485#Paired Box# FALSE 1643 ENSG00000196092 PAX5 Paired box Yes Known motif Monomer or homomultimer High-throughput in vitro None PDB:1K78 is a PAX5:ETS1 heterodimer IPR001523;IPR009057;IPR022130; 5079 paired box 5 [Source:HGNC Symbol;Acc:HGNC:8619] 1K78 DBD not tested None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:8406007 No 1a1, Direct HQ evidence Sam Lambert Arttu Jolma Yes $#ENSG00000196092#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019 $#ENSP00000350844#ENSG00000196092#ENST00000358127#Paired Box#Pax2_C$#ENSP00000367078#ENSG00000196092#ENST00000377847#Paired Box#Pax2_C$#ENSP00000367083#ENSG00000196092#ENST00000377852#Paired Box#Pax2_C$#ENSP00000367084#ENSG00000196092#ENST00000377853#Paired Box#Pax2_C$#ENSP00000412188#ENSG00000196092#ENST00000414447#Paired Box#Pax2_C$#ENSP00000404687#ENSG00000196092#ENST00000446742#Paired Box#Pax2_C$#ENSP00000429291#ENSG00000196092#ENST00000520154#Paired Box#$#ENSP00000430773#ENSG00000196092#ENST00000520281#Paired Box#Pax2_C$#ENSP00000429359#ENSG00000196092#ENST00000522003#Paired Box#Pax2_C$#ENSP00000428670#ENSG00000196092#ENST00000522932#Paired Box#Pax2_C$#ENSP00000429197#ENSG00000196092#ENST00000523145#Paired Box#Pax2_C$#ENSP00000429637#ENSG00000196092#ENST00000523241#Paired Box#$#ENSP00000429404#ENSG00000196092#ENST00000524340#Paired Box#Pax2_C FALSE 1644 ENSG00000125618 PAX8 Paired box Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001523;IPR009057;IPR022130; 7849 paired box 8 [Source:HGNC Symbol;Acc:HGNC:8622] None DBD and Full not tested None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:1508216 Yes 1a1, Direct HQ evidence Tim Hughes Matt Weirauch Yes $#ENSG00000125618#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000125618#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:9388203, PMID:9590296 $#ENSP00000263334#ENSG00000125618#ENST00000263334#Paired Box#Pax2_C$#ENSP00000263335#ENSG00000125618#ENST00000263335#Paired Box#$#ENSP00000314750#ENSG00000125618#ENST00000348715#Paired Box#$#ENSP00000380768#ENSG00000125618#ENST00000397647#Paired Box#$#ENSP00000395498#ENSG00000125618#ENST00000429538#Paired Box#Pax2_C$#ENSP00000452547#ENSG00000125618#ENST00000465084#Paired Box#Pax2_C$#ENSP00000451240#ENSG00000125618#ENST00000468980#Paired Box#Pax2_C FALSE 1645 ENSG00000198807 PAX9 Paired box Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001523;IPR009057 5083 paired box 9 [Source:HGNC Symbol;Acc:HGNC:8623] None DBD not tested None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:12490554;14607846 No 1a1, Direct HQ evidence Yimeng Yin Arttu Jolma Yes $#ENSG00000198807#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IEA - GO_REF:0000019 $#ENSP00000355245#ENSG00000198807#ENST00000361487#Paired Box#$#ENSP00000450434#ENSG00000198807#ENST00000554201#Paired Box#$#ENSP00000384817#ENSG00000198807#ENST00000402703#Paired Box# FALSE 1646 ENSG00000196233 LCOR Pipsqueak Yes Known motif Monomer or homomultimer 100 perc ID - in vitro None None IPR007889;IPR009057 84458 ligand dependent nuclear receptor corepressor [Source:HGNC Symbol;Acc:HGNC:29503] None DBD and Full not tested None None a Yes No No 1a2, Orthologous HQ evidence Arttu Jolma Pratyush Das No None $#ENSP00000360138#ENSG00000196233#ENST00000371097#Pipsqueak#$#ENSP00000360144#ENSG00000196233#ENST00000371103#Pipsqueak#$#ENSP00000443431#ENSG00000196233#ENST00000540664#Pipsqueak#$#ENSP00000348298#ENSG00000196233#ENST00000356016#Pipsqueak#$#ENSP00000286067#ENSG00000196233#ENST00000286067#Pipsqueak#DUF4553$#ENSP00000490116#ENSG00000196233#ENST00000421806#Pipsqueak#DUF4553 FALSE 1647 ENSG00000178177 LCORL Pipsqueak Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR007889;IPR009057 254251 ligand dependent nuclear receptor corepressor like [Source:HGNC Symbol;Acc:HGNC:30776] None Full Yes None None a Yes No No 1a1, Direct HQ evidence Jussi Taipale Pratyush Das No None $#ENSP00000317566#ENSG00000178177#ENST00000326877#Other#$#ENSP00000371659#ENSG00000178177#ENST00000382224#Other#DUF2428$#ENSP00000371661#ENSG00000178177#ENST00000382226#Other#DUF2428$#ENSP00000490600#ENSG00000178177#ENST00000635767#Other#DUF4553 FALSE 1648 ENSG00000117707 PROX1 Prospero Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR009057;IPR023082 5629 prospero homeobox 1 [Source:HGNC Symbol;Acc:HGNC:9459] None DBD not tested None None a Yes No Yes 1a1, Direct HQ evidence Matt Weirauch Yimeng Yin Yes $#ENSG00000117707#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IBA - GO_REF:0000033$#ENSG00000117707#GO:0003700#sequence-specific DNA binding transcription factor activity#IC - PMID:19210544$#ENSG00000117707#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024$#ENSG00000117707#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:15205472, PMID:16488887 $#ENSP00000261454#ENSG00000117707#ENST00000261454#Homeo-prospero domain#$#ENSP00000355925#ENSG00000117707#ENST00000366958#Homeo-prospero domain#$#ENSP00000400694#ENSG00000117707#ENST00000435016#Homeo-prospero domain#$#ENSP00000420283#ENSG00000117707#ENST00000498508#Homeo-prospero domain#$#ENSP00000419517#ENSG00000117707#ENST00000471129#Homeo-prospero domain#$#ENSP00000475357#ENSG00000117707#ENST00000607425#Homeo-prospero domain# FALSE 1649 ENSG00000119608 PROX2 Prospero Yes Inferred motif Monomer or homomultimer High-throughput in vitro None None IPR009057;IPR023082 283571 Prospero homeobox 2 [Source:HGNC Symbol;Acc:HGNC:26715] None DBD not tested None None a Yes No No 1a1, Direct HQ evidence Laura Campitelli Yimeng Yin Yes $#ENSG00000119608#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IBA - GO_REF:0000033 $#ENSP00000451223#ENSG00000119608#ENST00000556489#Homeo-prospero domain#$#ENSP00000451463#ENSG00000119608#ENST00000556084#Homeo-prospero domain#$#ENSP00000478947#ENSG00000119608#ENST00000619947#Homeo-prospero domain# FALSE 1650 ENSG00000102908 NFAT5 Rel Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR002909;IPR008366;IPR008967;IPR011539;IPR014756; 10725 nuclear factor of activated T-cells 5, tonicity-responsive [Source:HGNC Symbol;Acc:HGNC:7774] 1IMH DBD and Full not tested None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:10377394;11485737;16027109 Yes 1a1, Direct HQ evidence Matt Weirauch Yimeng Yin Yes $#ENSG00000102908#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:11485737$#ENSG00000102908#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:10051678 $#ENSP00000338806#ENSG00000102908#ENST00000349945#RHD#RHD_dimer$#ENSP00000346420#ENSG00000102908#ENST00000354436#RHD#RHD_dimer$#ENSP00000377343#ENSG00000102908#ENST00000393742#RHD#RHD_dimer$#ENSP00000455628#ENSG00000102908#ENST00000566899#RHD#RHD_dimer$#ENSP00000457593#ENSG00000102908#ENST00000567239#RHD#RHD_dimer$#ENSP00000463214#ENSG00000102908#ENST00000565301#RHD#$#ENSP00000486610#ENSG00000102908#ENST00000627621#RHD#RHD_dimer FALSE 1651 ENSG00000131196 NFATC1 Rel Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR002909;IPR008366;IPR008967;IPR011539;IPR014756; 4772 nuclear factor of activated T-cells 1 [Source:HGNC Symbol;Acc:HGNC:7775] 1A66 DBD and Full not tested None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; TF PPI; Transactivation_PMIDS:15117818;16109714 Yes 1a1, Direct HQ evidence Arttu Jolma Yimeng Yin Yes $#ENSG00000131196#GO:0001205#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involv#ISS - GO_REF:0000024$#ENSG00000131196#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:10821850, PMID:9506523$#ENSG00000131196#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024 $#ENSP00000253506#ENSG00000131196#ENST00000253506#RHD#RHD_dimer, TIG$#ENSP00000316553#ENSG00000131196#ENST00000318065#RHD#RHD_dimer, TIG$#ENSP00000327850#ENSG00000131196#ENST00000329101#RHD#RHD_dimer, TIG$#ENSP00000380892#ENSG00000131196#ENST00000397790#RHD#RHD_dimer, TIG$#ENSP00000389377#ENSG00000131196#ENST00000427363#RHD#RHD_dimer, TIG$#ENSP00000442435#ENSG00000131196#ENST00000542384#RHD#RHD_dimer, TIG$#ENSP00000466489#ENSG00000131196#ENST00000586434#RHD#RHD_dimer, TIG$#ENSP00000468111#ENSG00000131196#ENST00000587635#RHD#$#ENSP00000466194#ENSG00000131196#ENST00000591814#RHD#RHD_dimer, TIG$#ENSP00000467181#ENSG00000131196#ENST00000592223#RHD#RHD_dimer, TIG$#ENSP00000439992#ENSG00000131196#ENST00000545796#RHD#RHD_dimer, TIG FALSE 1652 ENSG00000101096 NFATC2 Rel Yes Known motif Monomer or homomultimer High-throughput in vitro None PDB:1A02 has NFAT, Fos and Jun trimeric complex with non-consensus bZIP target site IPR002909;IPR008366;IPR008967;IPR011539;IPR014756; 4773 nuclear factor of activated T-cells 2 [Source:HGNC Symbol;Acc:HGNC:7776] 1A02 DBD Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:10692237;11786533;8313907;8397339;15684054;12453415;14688323 Yes 1a1, Direct HQ evidence Matt Weirauch Yimeng Yin Yes $#ENSG00000101096#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000101096#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000101096#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:8668213 $#ENSP00000360619#ENSG00000101096#ENST00000371564#RHD#RHD_dimer, TIG$#ENSP00000379330#ENSG00000101096#ENST00000396009#RHD#RHD_dimer, TIG$#ENSP00000396471#ENSG00000101096#ENST00000414705#RHD#RHD_dimer, TIG$#ENSP00000477342#ENSG00000101096#ENST00000609507#RHD#RHD_dimer, TIG$#ENSP00000477370#ENSG00000101096#ENST00000609943#RHD#RHD_dimer, TIG$#ENSP00000477142#ENSG00000101096#ENST00000610033#RHD#RHD_dimer, TIG FALSE 1653 ENSG00000072736 NFATC3 Rel Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR002909;IPR008366;IPR008967;IPR011539;IPR014756; 4775 nuclear factor of activated T-cells 3 [Source:HGNC Symbol;Acc:HGNC:7777] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:7650004;7650004;11997392;15173172;7650004;15173172;15173172;16260608 Yes 1a1, Direct HQ evidence Tim Hughes Jussi Taipale Yes $#ENSG00000072736#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:15173172 | IMP - PMID:15173172$#ENSG00000072736#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IGI - PMID:23543060 $#ENSP00000331324#ENSG00000072736#ENST00000329524#RHD#RHD_dimer, TIG$#ENSP00000300659#ENSG00000072736#ENST00000346183#RHD#RHD_dimer, TIG$#ENSP00000264008#ENSG00000072736#ENST00000349223#RHD#RHD_dimer, TIG$#ENSP00000456120#ENSG00000072736#ENST00000562926#RHD#RHD_dimer, TIG$#ENSP00000456379#ENSG00000072736#ENST00000570212#RHD#RHD_dimer, TIG$#ENSP00000457441#ENSG00000072736#ENST00000565750#RHD# FALSE 1654 ENSG00000100968 NFATC4 Rel Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR002909;IPR008366;IPR008967;IPR011539;IPR014756; 4776 nuclear factor of activated T-cells 4 [Source:HGNC Symbol;Acc:HGNC:7778] None DBD Yes None None a Yes TF Gene_Transcription Factor Binding: tf co-factor binding_Co-activation_PMIDS:11514544;11997522;16644691;17430895;16644691;12796475;16644691 Yes 1a1, Direct HQ evidence Arttu Jolma Yimeng Yin Yes $#ENSG00000100968#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000100968#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IGI - PMID:23543060 $#ENSP00000250373#ENSG00000100968#ENST00000250373#RHD#RHD_dimer, TIG$#ENSP00000388910#ENSG00000100968#ENST00000413692#RHD#RHD_dimer, TIG$#ENSP00000396788#ENSG00000100968#ENST00000422617#RHD#RHD_dimer, TIG$#ENSP00000388668#ENSG00000100968#ENST00000424781#RHD#RHD_dimer, TIG$#ENSP00000439350#ENSG00000100968#ENST00000539237#RHD#RHD_dimer, TIG$#ENSP00000451502#ENSG00000100968#ENST00000553469#RHD#RHD_dimer, TIG$#ENSP00000450590#ENSG00000100968#ENST00000553708#RHD#RHD_dimer, TIG$#ENSP00000451151#ENSG00000100968#ENST00000554050#RHD#RHD_dimer, TIG$#ENSP00000450469#ENSG00000100968#ENST00000554344#RHD#RHD_dimer, TIG$#ENSP00000450810#ENSG00000100968#ENST00000554473#RHD#RHD_dimer, TIG$#ENSP00000452039#ENSG00000100968#ENST00000554591#RHD#RHD_dimer, TIG$#ENSP00000450733#ENSG00000100968#ENST00000554661#RHD#RHD_dimer, TIG$#ENSP00000450644#ENSG00000100968#ENST00000554966#RHD#RHD_dimer, TIG$#ENSP00000451395#ENSG00000100968#ENST00000555167#RHD#RHD_dimer, TIG$#ENSP00000451801#ENSG00000100968#ENST00000555393#RHD#$#ENSP00000450686#ENSG00000100968#ENST00000555453#RHD#RHD_dimer, TIG$#ENSP00000451224#ENSG00000100968#ENST00000555590#RHD#RHD_dimer, TIG$#ENSP00000451590#ENSG00000100968#ENST00000555802#RHD#$#ENSP00000451454#ENSG00000100968#ENST00000556169#RHD#RHD_dimer, TIG$#ENSP00000452270#ENSG00000100968#ENST00000556279#RHD#RHD_dimer, TIG$#ENSP00000451183#ENSG00000100968#ENST00000556759#RHD#RHD_dimer, TIG$#ENSP00000451284#ENSG00000100968#ENST00000557451#RHD#RHD_dimer, TIG$#ENSP00000452349#ENSG00000100968#ENST00000553879#RHD#RHD_dimer, TIG$#ENSP00000451496#ENSG00000100968#ENST00000557767#RHD# FALSE 1655 ENSG00000109320 NFKB1 Rel Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000451;IPR000488;IPR002110;IPR002909;IPR008967;IPR011029;IPR011539;IPR014756;IPR020683;IPR030492 4790 nuclear factor kappa B subunit 1 [Source:HGNC Symbol;Acc:HGNC:7794] 1LE5 DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:1406630 Yes 1a1, Direct HQ evidence Matt Weirauch Laura Campitelli Yes $#ENSG00000109320#GO:0001205#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involv#IDA - PMID:1406630$#ENSG00000109320#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IDA - PMID:24434510$#ENSG00000109320#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:17426251$#ENSG00000109320#GO:0051092#positive regulation of NF-kappaB transcription factor activity#TAS - Reactome:R-HSA-445989 $#ENSP00000226574#ENSG00000109320#ENST00000226574#RHD#Ank, Ank_2, Ank_3, Ank_4, Ank_5, Death, RHD_dimer$#ENSP00000378297#ENSG00000109320#ENST00000394820#RHD#Ank, Ank_2, Ank_3, Ank_4, Ank_5, Death, RHD_dimer$#ENSP00000424790#ENSG00000109320#ENST00000505458#RHD#Ank, Ank_2, Ank_3, Ank_4, Ank_5, Death, RHD_dimer$#ENSP00000469340#ENSG00000109320#ENST00000600343#RHD#Ank, Ank_2, Ank_3, Ank_4, Ank_5, Death, RHD_dimer$#ENSP00000424815#ENSG00000109320#ENST00000508584#RHD#RHD_dimer FALSE 1656 ENSG00000077150 NFKB2 Rel Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000451;IPR000488;IPR002110;IPR002909;IPR008967;IPR011029;IPR011539;IPR014756;IPR020683;IPR030492 4791 nuclear factor kappa B subunit 2 [Source:HGNC Symbol;Acc:HGNC:7795] 1A3Q DBD not tested None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:8360178 Yes 1a1, Direct HQ evidence Jussi Taipale Tim Hughes Yes $#ENSG00000077150#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:12835724$#ENSG00000077150#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:1760839, PMID:1876189$#ENSG00000077150#GO:0051092#positive regulation of NF-kappaB transcription factor activity#TAS - Reactome:R-HSA-445989 $#ENSP00000189444#ENSG00000077150#ENST00000189444#RHD#Ank, Ank_2, Ank_3, Ank_4, Ank_5, Death, RHD_dimer$#ENSP00000358983#ENSG00000077150#ENST00000369966#RHD#Ank, Ank_2, Ank_3, Ank_4, Ank_5, Death, RHD_dimer$#ENSP00000410256#ENSG00000077150#ENST00000428099#RHD#Ank, Ank_2, Ank_3, Ank_4, Ank_5, Death, RHD_dimer$#ENSP00000471586#ENSG00000077150#ENST00000471698#RHD# FALSE 1657 ENSG00000162924 REL Rel Yes Known motif Monomer or homomultimer In vivo/Misc source None None IPR000451;IPR002909;IPR008967;IPR011539;IPR014756;IPR030492 5966 REL proto-oncogene, NF-kB subunit [Source:HGNC Symbol;Acc:HGNC:9954] 1GJI DBD and Full not tested None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:1406630 Yes 1a1, Direct HQ evidence Laura Campitelli Yimeng Yin Yes $#ENSG00000162924#GO:0001205#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involv#IDA - PMID:1406630$#ENSG00000162924#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:8423996 $#ENSP00000295025#ENSG00000162924#ENST00000295025#RHD#RHD_dimer$#ENSP00000377989#ENSG00000162924#ENST00000394479#RHD#RHD_dimer FALSE 1658 ENSG00000173039 RELA Rel Yes Known motif Monomer or homomultimer In vivo/Misc source None Can bind as a homodimer or heterodimer (PMID: 22101729). pmid:19683540 forms heterodimer with NFKB1, citation is a crystal structure IPR000451;IPR002909;IPR008967;IPR011539;IPR014756;IPR030492 5970 RELA proto-oncogene, NF-kB subunit [Source:HGNC Symbol;Acc:HGNC:9955] 3GUT DBD and Full not tested None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:1935902;15485852;15857826 Yes 1a1, Direct HQ evidence Sam Lambert Jussi Taipale Yes $#ENSG00000173039#GO:0000983#RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity#IMP - PMID:26268439$#ENSG00000173039#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:17350185$#ENSG00000173039#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:17350185$#ENSG00000173039#GO:0001205#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involv#IDA - PMID:1406630$#ENSG00000173039#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:12048232$#ENSG00000173039#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#IDA - PMID:3091258$#ENSG00000173039#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IDA - PMID:15790681 | TAS - Reactome:R-HSA-445989 $#ENSP00000311508#ENSG00000173039#ENST00000308639#RHD#RHD_dimer$#ENSP00000384273#ENSG00000173039#ENST00000406246#RHD#RHD_dimer$#ENSP00000432537#ENSG00000173039#ENST00000525693#RHD#RHD_dimer$#ENSP00000431304#ENSG00000173039#ENST00000526257#RHD#$#ENSP00000483705#ENSG00000173039#ENST00000612991#RHD#RHD_dimer$#ENSP00000434098#ENSG00000173039#ENST00000533187#RHD# FALSE 1659 ENSG00000104856 RELB Rel Yes Known motif Obligate heteromer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain Likely an obligate heteromer (PMID: 22101729), pmid:17869269 forms heterodimer with NFKB1, citation is a crystal structure IPR000451;IPR002909;IPR008967;IPR011539;IPR014756;IPR030492 5971 RELB proto-oncogene, NF-kB subunit [Source:HGNC Symbol;Acc:HGNC:9956] 2V2T DBD and Full not tested None None a Yes TF Gene_DNA-Binding: sequence-specific; Transcription Factor Binding: tf co-factor binding_Co-activation_PMIDS:8183565;8183565;9070378 Yes 1a1, Direct HQ evidence Matt Weirauch Sam Lambert Yes $#ENSG00000104856#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000104856#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:8188306 $#ENSP00000221452#ENSG00000104856#ENST00000221452#RHD#RHD_dimer, RelB_leu_zip, RelB_transactiv$#ENSP00000468460#ENSG00000104856#ENST00000589972#RHD#RelB_transactiv$#ENSP00000423287#ENSG00000104856#ENST00000505236#RHD#RHD_dimer, RelB_leu_zip, RelB_transactiv$#ENSP00000485826#ENSG00000104856#ENST00000625761#RHD#RHD_dimer, RelB_leu_zip, RelB_transactiv FALSE 1660 ENSG00000132005 RFX1 RFX Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR003150;IPR007668 5989 regulatory factor X1 [Source:HGNC Symbol;Acc:HGNC:9982] 1DP7 DBD Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_Co-activation; DNA Binding_PMIDS:11986307;16464847 Yes 1a1, Direct HQ evidence Arttu Jolma Laura Campitelli Yes $#ENSG00000132005#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#TAS - PMID:8289803 $#ENSP00000254325#ENSG00000132005#ENST00000254325#RFX#RFX1_trans_act$#ENSP00000464960#ENSG00000132005#ENST00000588885#RFX# FALSE 1661 ENSG00000087903 RFX2 RFX Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR003150;IPR007668 5990 regulatory factor X2 [Source:HGNC Symbol;Acc:HGNC:9983] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:8289803;16676351 Yes 1a1, Direct HQ evidence Arttu Jolma Yimeng Yin Yes $#ENSG00000087903#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 | ISS - GO_REF:0000024 $#ENSP00000306335#ENSG00000087903#ENST00000303657#RFX#RFX1_trans_act$#ENSP00000352076#ENSG00000087903#ENST00000359161#RFX#RFX1_trans_act$#ENSP00000467166#ENSG00000087903#ENST00000592546#RFX#RFX1_trans_act$#ENSP00000467736#ENSG00000087903#ENST00000586806#RFX#$#ENSP00000465122#ENSG00000087903#ENST00000587321#RFX#$#ENSP00000466890#ENSG00000087903#ENST00000593241#RFX#RFX1_trans_act FALSE 1662 ENSG00000080298 RFX3 RFX Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR003150;IPR007668 5991 regulatory factor X3 [Source:HGNC Symbol;Acc:HGNC:9984] None DBD and Full Yes None None a Yes No Yes 1a1, Direct HQ evidence Jussi Taipale Pratyush Das Yes $#ENSG00000080298#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:8600444$#ENSG00000080298#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#TAS - PMID:8289803 $#ENSP00000303847#ENSG00000080298#ENST00000302303#RFX#RFX1_trans_act$#ENSP00000351574#ENSG00000080298#ENST00000358730#RFX#RFX1_trans_act$#ENSP00000371434#ENSG00000080298#ENST00000382004#RFX#RFX1_trans_act$#ENSP00000482598#ENSG00000080298#ENST00000617270#RFX#RFX1_trans_act$#ENSP00000371414#ENSG00000080298#ENST00000381984#RFX#RFX1_trans_act$#ENSP00000416189#ENSG00000080298#ENST00000420720#RFX#RFX1_trans_act$#ENSP00000410988#ENSG00000080298#ENST00000442560#RFX#RFX1_trans_act$#ENSP00000399352#ENSG00000080298#ENST00000449190#RFX#RFX1_trans_act$#ENSP00000415594#ENSG00000080298#ENST00000449234#RFX#$#ENSP00000411756#ENSG00000080298#ENST00000451859#RFX#RFX1_trans_act$#ENSP00000400026#ENSG00000080298#ENST00000458034#RFX#HisKA FALSE 1663 ENSG00000111783 RFX4 RFX Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR003150; 5992 regulatory factor X4 [Source:HGNC Symbol;Acc:HGNC:9985] None DBD and Full Yes None None b Yes TF Gene Candidate_DNA-Binding: sequence-specific_Co-activation; DNA Binding_PMIDS:11682486 Yes 1a1, Direct HQ evidence Yimeng Yin Matt Weirauch Yes $#ENSG00000111783#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:16893423 $#ENSP00000229387#ENSG00000111783#ENST00000229387#RFX#$#ENSP00000350552#ENSG00000111783#ENST00000357881#RFX#$#ENSP00000376585#ENSG00000111783#ENST00000392842#RFX#$#ENSP00000447735#ENSG00000111783#ENST00000549040#RFX# FALSE 1664 ENSG00000143390 RFX5 RFX Yes Known motif Monomer or homomultimer High-throughput in vitro Has a putative AT-hook None IPR003150;IPR029298 5993 regulatory factor X5 [Source:HGNC Symbol;Acc:HGNC:9986] None DBD and Full not tested None None a Yes TF Gene Candidate_Transcription Factor Binding: tf co-factor binding; DNA-Binding: sequence-specific_Co-activation_PMIDS:9806546 Yes 1a1, Direct HQ evidence Yimeng Yin Matt Weirauch Yes $#ENSG00000143390#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000290524#ENSG00000143390#ENST00000290524#RFX#RFX5_DNA_bdg$#ENSP00000389130#ENSG00000143390#ENST00000452671#RFX#RFX5_DNA_bdg$#ENSP00000396810#ENSG00000143390#ENST00000412774#RFX#$#ENSP00000390769#ENSG00000143390#ENST00000436637#RFX#$#ENSP00000398666#ENSG00000143390#ENST00000450506#RFX#$#ENSP00000409187#ENSG00000143390#ENST00000458484#RFX# FALSE 1665 ENSG00000185002 RFX6 RFX Yes Inferred motif Monomer or homomultimer High-throughput in vitro None None IPR003150; 222546 regulatory factor X6 [Source:HGNC Symbol;Acc:HGNC:21478] None not tested not tested None None x Yes No Yes 1a2, Orthologous HQ evidence Arttu Jolma Laura Campitelli Yes $#ENSG00000185002#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IDA - PMID:20148032 $#ENSP00000332208#ENSG00000185002#ENST00000332958#RFX# FALSE 1666 ENSG00000181827 RFX7 RFX Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR003150; 64864 regulatory factor X7 [Source:HGNC Symbol;Acc:HGNC:25777] None DBD and Full Yes None None b Yes No Yes 1a1, Direct HQ evidence Sam Lambert Pratyush Das Yes $#ENSG00000181827#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000453611#ENSG00000181827#ENST00000560792#RFX#$#ENSP00000453281#ENSG00000181827#ENST00000559447#RFX# FALSE 1667 ENSG00000196460 RFX8 RFX Yes Likely to be sequence specific TF Monomer or homomultimer No motif None RFX8 has the HUGO-approved name RFX family member 8, lacking RFX DNA binding domain?.? I cannot find the original evidence, however, and RFX8 clearly encodes a complete and high-confidence RFX DNA binding domain.? So, it seems more likely than not to be DNA binding (TRH) None 731220 RFX family member 8, lacking RFX DNA binding domain [Source:HGNC Symbol;Acc:HGNC:37253] None DBD not tested None None b Yes No No 1a2, Orthologous HQ evidence Pratyush Das Yimeng Yin Yes $#ENSG00000196460#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000401536#ENSG00000196460#ENST00000428343#RFX# FALSE 1668 ENSG00000159216 RUNX1 Runt Yes Known motif Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain None IPR000040;IPR008967;IPR013524;IPR013711;IPR016554; 100506403 runt related transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:10471] 1HJC DBD and Full not tested None None a Yes TF Gene_DNA-Binding: sequence-specific_Transactivation_PMIDS:7609063;8035830 Yes 1a1, Direct HQ evidence Matt Weirauch Arttu Jolma Yes $#ENSG00000159216#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IDA - PMID:9199349 | IMP - PMID:9199349 $#ENSP00000300305#ENSG00000159216#ENST00000300305#RUNX#RunxI$#ENSP00000340690#ENSG00000159216#ENST00000344691#RUNX#RunxI$#ENSP00000351123#ENSG00000159216#ENST00000358356#RUNX#$#ENSP00000405158#ENSG00000159216#ENST00000416754#RUNX#$#ENSP00000382184#ENSG00000159216#ENST00000399240#RUNX#RunxI$#ENSP00000388189#ENSG00000159216#ENST00000455571#RUNX# FALSE 1669 ENSG00000124813 RUNX2 Runt Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000040;IPR008967;IPR013524;IPR013711;IPR016554; 860 runt related transcription factor 2 [Source:HGNC Symbol;Acc:HGNC:10472] None DBD Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:11451945;16574347 Yes 1a1, Direct HQ evidence Yimeng Yin Jussi Taipale Yes $#ENSG00000124813#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000124813#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000124813#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:9182765 $#ENSP00000485863#ENSG00000124813#ENST00000625924#RUNX#DUF2722, RunxI, Spt20$#ENSP00000352514#ENSG00000124813#ENST00000359524#RUNX#DUF2722, RunxI, Spt20 FALSE 1670 ENSG00000020633 RUNX3 Runt Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000040;IPR008967;IPR013524;IPR013711;IPR016554; 864 runt related transcription factor 3 [Source:HGNC Symbol;Acc:HGNC:10473] None DBD and Full not tested None None a Yes TF Gene_DNA-Binding: sequence-specific_Transactivation_PMIDS:15688019;16164020 Yes 1a1, Direct HQ evidence Pratyush Das Sam Lambert Yes $#ENSG00000020633#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033 | ISS - GO_REF:0000024$#ENSG00000020633#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:7607690 $#ENSP00000308051#ENSG00000020633#ENST00000308873#RUNX#RunxI$#ENSP00000343477#ENSG00000020633#ENST00000338888#RUNX#RunxI$#ENSP00000382800#ENSG00000020633#ENST00000399916#RUNX#RunxI FALSE 1671 ENSG00000160224 AIRE SAND Yes Known motif Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain Binds to TTATTA and tandem repeats of ATTGGTTA (PMID: 11533054) IPR000770;IPR001965;IPR004865;IPR008087;IPR010919;IPR011011;IPR019786;IPR019787 326 autoimmune regulator [Source:HGNC Symbol;Acc:HGNC:360] None DBD and Full not tested None None a Yes TF Gene Candidate_DNA-Binding: sequence-specific_DNA Binding_PMIDS:10022980;10049735;12376594;10748110;11274163;11533054;10748110;15649436;10677297;15649436 Yes 2a1, Lower confidence direct evidence Jussi Taipale Matt Weirauch Yes $#ENSG00000160224#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IC - GO_REF:0000036 $#ENSP00000291582#ENSG00000160224#ENST00000291582#SAND#HSR, PHD, PHD_2, zf-HC5HC2H FALSE 1672 ENSG00000177030 DEAF1 SAND Yes Inferred motif Monomer or homomultimer In vivo/Misc source None None IPR000770;IPR002893;IPR010919; 10522 DEAF1, transcription factor [Source:HGNC Symbol;Acc:HGNC:14677] None DBD Yes None None a Yes No No 2a2, orthologous lower confidence evidence Yimeng Yin Pratyush Das Yes $#ENSG00000177030#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000371846#ENSG00000177030#ENST00000382409#SAND#zf-MYND FALSE 1673 ENSG00000102393 GLA SAND No Unlikely to be sequence specific TF Not a DNA binding protein No motif None GLA appears to lack a functional SAND domain. It encodes a well-characterized enzyme, Galactosidase Alpha. Most of the polypeptide encodes a glycoside hydrolase domain and most of the rest encodes another pfam domain called Glycoside hydrolase family 27. It has a low-scoring SAND domain match that almost certainly overlaps with a known domain related to its function as an enzyme. IPR000111;IPR002241;IPR017853 2717 galactosidase alpha [Source:HGNC Symbol;Acc:HGNC:4296] None not tested not tested None None No Yes No No 5a, one of the source datasets predicts is as a TF Jussi Taipale Tim Hughes No None $#ENSP00000218516#ENSG00000102393#ENST00000218516#SAND#Melibiase, Melibiase_2 FALSE 1674 ENSG00000162419 GMEB1 SAND Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000770;IPR010919 10691 glucocorticoid modulatory element binding protein 1 [Source:HGNC Symbol;Acc:HGNC:4370] None DBD and Full Yes None None a Yes TF Gene_Transcription Factor Binding: tf co-factor binding; DNA-Binding: sequence-specific_DNA Binding_PMIDS:10386584;10692587;10894151;11934901 No 1a1, Direct HQ evidence Arttu Jolma Pratyush Das Yes $#ENSG00000162419#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019 $#ENSP00000294409#ENSG00000162419#ENST00000294409#SAND#$#ENSP00000355186#ENSG00000162419#ENST00000361872#SAND#$#ENSP00000362922#ENSG00000162419#ENST00000373816#SAND# FALSE 1675 ENSG00000101216 GMEB2 SAND Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000770;IPR010919 26205 glucocorticoid modulatory element binding protein 2 [Source:HGNC Symbol;Acc:HGNC:4371] None DBD Yes None None a Yes TF Gene_Transcription Factor Binding: tf co-factor binding; DNA-Binding: sequence-specific_DNA Binding; TF PPI_PMIDS:10894151;14705952 No 1a1, Direct HQ evidence Laura Campitelli Tim Hughes Yes None $#ENSP00000266068#ENSG00000101216#ENST00000266068#SAND#$#ENSP00000359094#ENSG00000101216#ENST00000370077#SAND#$#ENSP00000359086#ENSG00000101216#ENST00000370069#SAND# FALSE 1676 ENSG00000215474 SKOR2 SAND Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR003380;IPR009061;IPR010919;IPR014890 652991 SKI family transcriptional corepressor 2 [Source:HGNC Symbol;Acc:HGNC:32695] None DBD not tested None None b No No Yes 1a1, Direct HQ evidence Pratyush Das Jussi Taipale No $#ENSG00000215474#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IBA - GO_REF:0000033 $#ENSP00000383255#ENSG00000215474#ENST00000400404#SAND#Ski_Sno, c-SKI_SMAD_bind$#ENSP00000414750#ENSG00000215474#ENST00000425639#SAND#Ski_Sno, c-SKI_SMAD_bind$#ENSP00000483333#ENSG00000215474#ENST00000620245#SAND#Ski_Sno, c-SKI_SMAD_bind FALSE 1677 ENSG00000067066 SP100 SAND Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Gel-shift experiments using human SP100 have shown binding to specific TTCG half sites (PMID: 11427895). IPR000770;IPR001487;IPR001965;IPR004865;IPR009071;IPR010919;IPR011011;IPR019786;IPR019787; 6672 SP100 nuclear antigen [Source:HGNC Symbol;Acc:HGNC:11206] None not tested Yes None None c Yes No Yes 1a1, Direct HQ evidence Pratyush Das Sam Lambert Yes $#ENSG00000067066#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:15247905 $#ENSP00000264052#ENSG00000067066#ENST00000264052#HMG#HSR$#ENSP00000343023#ENSG00000067066#ENST00000340126#HMG#Bromodomain, HSR, PHD$#ENSP00000386427#ENSG00000067066#ENST00000409112#HMG#HSR$#ENSP00000386404#ENSG00000067066#ENST00000409341#HMG#HSR$#ENSP00000393679#ENSG00000067066#ENST00000431952#HMG#Bromodomain, PHD$#ENSP00000386998#ENSG00000067066#ENST00000409897#HMG#HSR$#ENSP00000399389#ENSG00000067066#ENST00000427101#HMG#HSR$#ENSP00000416563#ENSG00000067066#ENST00000452345#HMG#$#ENSP00000400277#ENSG00000067066#ENST00000413284#HMG#$#ENSP00000391616#ENSG00000067066#ENST00000432979#HMG#HSR FALSE 1678 ENSG00000135899 SP110 SAND Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR000770;IPR001487;IPR001965;IPR004865;IPR010919;IPR011011;IPR019786;IPR019787 3431 SP110 nuclear body protein [Source:HGNC Symbol;Acc:HGNC:5401] None DBD and Full Yes None None b Yes No No 1a1, Direct HQ evidence Yimeng Yin Arttu Jolma Yes None $#ENSP00000258382#ENSG00000135899#ENST00000258382#SAND#HSR$#ENSP00000351488#ENSG00000135899#ENST00000358662#SAND#HSR, PHD$#ENSP00000375902#ENSG00000135899#ENST00000392048#SAND#HSR$#ENSP00000258381#ENSG00000135899#ENST00000258381#SAND#HSR, PHD FALSE 1679 ENSG00000079263 SP140 SAND Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR000770;IPR001487;IPR001965;IPR004865;IPR010919;IPR011011;IPR019786;IPR019787 11262 SP140 nuclear body protein [Source:HGNC Symbol;Acc:HGNC:17133] None Full Yes None None x Yes No Yes 4a, two or more datasets predict it as a TF Matt Weirauch Jussi Taipale Yes $#ENSG00000079263#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:8695863 $#ENSP00000342096#ENSG00000079263#ENST00000343805#SAND#Bromodomain, HSR, PHD$#ENSP00000362749#ENSG00000079263#ENST00000373645#SAND#HSR$#ENSP00000393618#ENSG00000079263#ENST00000417495#SAND#Bromodomain, HSR, PHD$#ENSP00000398210#ENSG00000079263#ENST00000420434#SAND#Bromodomain, HSR, PHD$#ENSP00000375899#ENSG00000079263#ENST00000392045#SAND#Bromodomain, HSR, PHD FALSE 1680 ENSG00000185404 SP140L SAND Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR000770;IPR001487;IPR001965;IPR004865;IPR010919;IPR011011;IPR019786;IPR019787 93349 SP140 nuclear body protein like [Source:HGNC Symbol;Acc:HGNC:25105] None DBD not tested None None b Yes No No 4a, two or more datasets predict it as a TF Jussi Taipale Yimeng Yin Yes None $#ENSP00000243810#ENSG00000185404#ENST00000243810#SAND#Bromodomain, HSR, PHD$#ENSP00000379811#ENSG00000185404#ENST00000396563#SAND#Bromodomain, HSR, PHD$#ENSP00000395223#ENSG00000185404#ENST00000458341#SAND#HSR FALSE 1681 ENSG00000175467 SART1 SART-1 No ssDNA/RNA binding Not a DNA binding protein No motif None Likely an RNA-binding protein IPR005011; 9092 squamous cell carcinoma antigen recognized by T-cells 1 [Source:HGNC Symbol;Acc:HGNC:10538] None not tested not tested None None No Yes No No 5a, one of the source datasets predicts is as a TF Yimeng Yin Sam Lambert No None $#ENSP00000310448#ENSG00000175467#ENST00000312397#SART-1# FALSE 1682 ENSG00000241343 RPL36A SBP No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Protein is a ribosomal component IPR000552;IPR011332 6173 ribosomal protein L36a [Source:HGNC Symbol;Acc:HGNC:10359] None not tested not tested None None No Yes No No 5a, one of the source datasets predicts is as a TF Arttu Jolma Yimeng Yin No None $#ENSP00000404375#ENSG00000241343#ENST00000427805#SBP#$#ENSP00000446503#ENSG00000241343#ENST00000553110#SBP#Ribosomal_L44$#ENSP00000483017#ENSG00000241343#ENST00000614077#SBP#$#ENSP00000397659#ENSG00000241343#ENST00000392994#SBP#Ribosomal_L44$#ENSP00000473451#ENSG00000241343#ENST00000471855#SBP# FALSE 1683 ENSG00000162599 NFIA SMAD Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000647;IPR003619;IPR019548;IPR019739;IPR020604; 4774 nuclear factor I A [Source:HGNC Symbol;Acc:HGNC:7784] None DBD and Full not tested None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; TF PPI; Transactivation_PMIDS:16169882;17010934 Yes 1a1, Direct HQ evidence Arttu Jolma Sam Lambert Yes $#ENSG00000162599#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:17010934$#ENSG00000162599#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:7590749 $#ENSP00000360229#ENSG00000162599#ENST00000371187#MH1 Family DBDs#CTF_NFI, NfI_DNAbd_pre-N$#ENSP00000384523#ENSG00000162599#ENST00000403491#MH1 Family DBDs#CTF_NFI, NfI_DNAbd_pre-N$#ENSP00000474817#ENSG00000162599#ENST00000493627#MH1 Family DBDs#CTF_NFI$#ENSP00000474462#ENSG00000162599#ENST00000357977#MH1 Family DBDs#CTF_NFI$#ENSP00000360231#ENSG00000162599#ENST00000371189#MH1 Family DBDs#CTF_NFI, NfI_DNAbd_pre-N$#ENSP00000384680#ENSG00000162599#ENST00000407417#MH1 Family DBDs#CTF_NFI, NfI_DNAbd_pre-N$#ENSP00000474461#ENSG00000162599#ENST00000476646#MH1 Family DBDs#CTF_NFI$#ENSP00000474806#ENSG00000162599#ENST00000482020#MH1 Family DBDs#CTF_NFI$#ENSP00000473830#ENSG00000162599#ENST00000496712#MH1 Family DBDs# FALSE 1684 ENSG00000147862 NFIB SMAD Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000647;IPR003619;IPR019548;IPR019739;IPR020604; 4781 nuclear factor I B [Source:HGNC Symbol;Acc:HGNC:7785] None DBD and Full Yes None None a Yes No Yes 1a1, Direct HQ evidence Sam Lambert Matt Weirauch Yes $#ENSG00000147862#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IDA - PMID:19540848, PMID:9099724$#ENSG00000147862#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:19540848 $#ENSP00000370308#ENSG00000147862#ENST00000380921#MH1 Family DBDs#NfI_DNAbd_pre-N$#ENSP00000370340#ENSG00000147862#ENST00000380953#MH1 Family DBDs#CTF_NFI, NfI_DNAbd_pre-N$#ENSP00000370346#ENSG00000147862#ENST00000380959#MH1 Family DBDs#CTF_NFI, NfI_DNAbd_pre-N$#ENSP00000442888#ENSG00000147862#ENST00000543693#MH1 Family DBDs#CTF_NFI$#ENSP00000370321#ENSG00000147862#ENST00000380934#MH1 Family DBDs#CTF_NFI, NfI_DNAbd_pre-N$#ENSP00000380705#ENSG00000147862#ENST00000397575#MH1 Family DBDs#CTF_NFI, NfI_DNAbd_pre-N$#ENSP00000475362#ENSG00000147862#ENST00000493697#MH1 Family DBDs#NfI_DNAbd_pre-N$#ENSP00000475813#ENSG00000147862#ENST00000606230#MH1 Family DBDs#CTF_NFI, NfI_DNAbd_pre-N$#ENSP00000490945#ENSG00000147862#ENST00000635877#MH1 Family DBDs#CTF_NFI, NfI_DNAbd_pre-N$#ENSP00000490762#ENSG00000147862#ENST00000636057#MH1 Family DBDs#CTF_NFI, NfI_DNAbd_pre-N$#ENSP00000489634#ENSG00000147862#ENST00000636063#MH1 Family DBDs#CTF_NFI, NfI_DNAbd_pre-N$#ENSP00000490588#ENSG00000147862#ENST00000636432#MH1 Family DBDs#CTF_NFI, NfI_DNAbd_pre-N$#ENSP00000490864#ENSG00000147862#ENST00000636735#MH1 Family DBDs#CTF_NFI$#ENSP00000490020#ENSG00000147862#ENST00000637640#MH1 Family DBDs#CTF_NFI, NfI_DNAbd_pre-N$#ENSP00000490950#ENSG00000147862#ENST00000637742#MH1 Family DBDs#CTF_NFI, NfI_DNAbd_pre-N FALSE 1685 ENSG00000141905 NFIC SMAD Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000647;IPR003619;IPR019548;IPR019739;IPR020604; 4782 nuclear factor I C [Source:HGNC Symbol;Acc:HGNC:7786] None DBD and Full not tested None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:2504497 Yes 1a1, Direct HQ evidence Arttu Jolma Matt Weirauch Yes $#ENSG00000141905#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:1524678$#ENSG00000141905#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:1524678 $#ENSP00000342194#ENSG00000141905#ENST00000341919#MH1 Family DBDs#CTF_NFI, NfI_DNAbd_pre-N$#ENSP00000465655#ENSG00000141905#ENST00000589123#MH1 Family DBDs#CTF_NFI, NfI_DNAbd_pre-N$#ENSP00000378543#ENSG00000141905#ENST00000395111#MH1 Family DBDs#CTF_NFI, NfI_DNAbd_pre-N$#ENSP00000396843#ENSG00000141905#ENST00000443272#MH1 Family DBDs#CTF_NFI, NfI_DNAbd_pre-N$#ENSP00000466647#ENSG00000141905#ENST00000590282#MH1 Family DBDs#CTF_NFI, NfI_DNAbd_pre-N FALSE 1686 ENSG00000008441 NFIX SMAD Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000647;IPR003619;IPR019548;IPR019739;IPR020604; 4784 nuclear factor I X [Source:HGNC Symbol;Acc:HGNC:7788] None DBD and Full not tested None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:9660824;9822643 Yes 1a1, Direct HQ evidence Jussi Taipale Sam Lambert Yes $#ENSG00000008441#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:7590749, PMID:8340106$#ENSG00000008441#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#TAS - PMID:7937100 $#ENSP00000380781#ENSG00000008441#ENST00000397661#MH1 Family DBDs#CTF_NFI, NfI_DNAbd_pre-N$#ENSP00000467785#ENSG00000008441#ENST00000587260#MH1 Family DBDs#CTF_NFI, NfI_DNAbd_pre-N$#ENSP00000466389#ENSG00000008441#ENST00000587760#MH1 Family DBDs#CTF_NFI, NfI_DNAbd_pre-N$#ENSP00000466735#ENSG00000008441#ENST00000588228#MH1 Family DBDs#CTF_NFI$#ENSP00000465616#ENSG00000008441#ENST00000590027#MH1 Family DBDs#$#ENSP00000468707#ENSG00000008441#ENST00000586873#MH1 Family DBDs#$#ENSP00000465094#ENSG00000008441#ENST00000591028#MH1 Family DBDs#NfI_DNAbd_pre-N FALSE 1687 ENSG00000170365 SMAD1 SMAD Yes Known motif Obligate heteromer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain Well-established obligate heteromer IPR001132;IPR003619;IPR008984;IPR013019 4086 SMAD family member 1 [Source:HGNC Symbol;Acc:HGNC:6767] 3KMP DBD and Full not tested None 3KMP is a homodimer a Yes No Yes 1a1, Direct HQ evidence Jussi Taipale Sam Lambert Yes $#ENSG00000170365#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:12270938$#ENSG00000170365#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:9389648 $#ENSP00000305769#ENSG00000170365#ENST00000302085#MH1 Family DBDs#IRF-3, MH2$#ENSP00000377652#ENSG00000170365#ENST00000394092#MH1 Family DBDs#IRF-3, MH2$#ENSP00000427002#ENSG00000170365#ENST00000512019#MH1 Family DBDs#$#ENSP00000425270#ENSG00000170365#ENST00000514831#MH1 Family DBDs#$#ENSP00000426568#ENSG00000170365#ENST00000515385#MH1 Family DBDs#IRF-3, MH2$#ENSP00000421601#ENSG00000170365#ENST00000507367#MH1 Family DBDs# FALSE 1688 ENSG00000175387 SMAD2 SMAD No Unlikely to be sequence specific TF Not a DNA binding protein No motif Only known motifs are from Transfac or HocoMoco - origin is uncertain A 30 amino-acid insertion encoded by exon 3 is thought to displace the hairpin loop, providing a structural explanation for SMAD2s lack of DNA-binding activity (PMID: 11532220). IPR001132;IPR003619;IPR008984;IPR013019 4087 SMAD family member 2 [Source:HGNC Symbol;Acc:HGNC:6768] None DBD not tested Heterodimerizes with SMAD4 pmid: PMID: 16322555, a review SMAD[1235] are supposed to be SMAD:s that bind DNA with SMAD4 as heteromultimers a Yes No Yes 2a1, Lower confidence direct evidence Yimeng Yin Arttu Jolma Yes $#ENSG00000175387#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:9389648$#ENSG00000175387#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:17438144, PMID:9389648 $#ENSP00000262160#ENSG00000175387#ENST00000262160#MH1 Family DBDs#IRF-3, MH2$#ENSP00000349282#ENSG00000175387#ENST00000356825#MH1 Family DBDs#IRF-3, MH2$#ENSP00000384449#ENSG00000175387#ENST00000402690#MH1 Family DBDs#IRF-3, MH2$#ENSP00000467075#ENSG00000175387#ENST00000591214#MH1 Family DBDs#IRF-3, MH2$#ENSP00000468732#ENSG00000175387#ENST00000585978#MH1 Family DBDs#$#ENSP00000466254#ENSG00000175387#ENST00000587269#MH1 Family DBDs#$#ENSP00000465971#ENSG00000175387#ENST00000589877#MH1 Family DBDs# FALSE 1689 ENSG00000166949 SMAD3 SMAD Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001132;IPR003619;IPR008984;IPR013019 4088 SMAD family member 3 [Source:HGNC Symbol;Acc:HGNC:6769] 1MHD DBD and Full Yes None None a Yes TF Gene Candidate_DNA-Binding: sequence-specific_DNA Binding_PMIDS:9660945 Yes 1a1, Direct HQ evidence Matt Weirauch Arttu Jolma Yes $#ENSG00000166949#GO:0000983#RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity#IDA - PMID:21947082 | IMP - PMID:26311719$#ENSG00000166949#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:10823886, PMID:21947082, PMID:9111321, $#ENSP00000332973#ENSG00000166949#ENST00000327367#MH1 Family DBDs#IRF-3, MH2$#ENSP00000401133#ENSG00000166949#ENST00000439724#MH1 Family DBDs#IRF-3, MH2$#ENSP00000445348#ENSG00000166949#ENST00000537194#MH1 Family DBDs#IRF-3, MH2$#ENSP00000437757#ENSG00000166949#ENST00000540846#MH1 Family DBDs#IRF-3, MH2$#ENSP00000453684#ENSG00000166949#ENST00000558739#MH1 Family DBDs#$#ENSP00000455540#ENSG00000166949#ENST00000560424#MH1 Family DBDs#MH2 FALSE 1690 ENSG00000141646 SMAD4 SMAD Yes Known motif Monomer or homomultimer 100 perc ID - in vitro None None IPR001132;IPR003619;IPR008984;IPR013019 4089 SMAD family member 4 [Source:HGNC Symbol;Acc:HGNC:6770] 3QSV DBD and Full Yes None 3QSV is a homodimeric complex a Yes No Yes 1a1, Direct HQ evidence Yimeng Yin Matt Weirauch Yes $#ENSG00000141646#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:9389648$#ENSG00000141646#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:10823886, PMID:17438144 $#ENSP00000465874#ENSG00000141646#ENST00000589941#MH1 Family DBDs#$#ENSP00000466941#ENSG00000141646#ENST00000591914#MH1 Family DBDs#$#ENSP00000466118#ENSG00000141646#ENST00000593223#MH1 Family DBDs#MH2 FALSE 1691 ENSG00000113658 SMAD5 SMAD Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001132;IPR003619;IPR008984;IPR013019 4090 SMAD family member 5 [Source:HGNC Symbol;Acc:HGNC:6771] 4ZKG DBD and Full not tested None None a Yes TF Gene Candidate_DNA-Binding: sequence-specific_DNA Binding_PMIDS:11527422 No 1a1, Direct HQ evidence Arttu Jolma Laura Campitelli Yes $#ENSG00000113658#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002 $#ENSP00000425749#ENSG00000113658#ENST00000507118#MH1 Family DBDs#$#ENSP00000426696#ENSG00000113658#ENST00000509297#MH1 Family DBDs#$#ENSP00000424279#ENSG00000113658#ENST00000511116#MH1 Family DBDs#$#ENSP00000427330#ENSG00000113658#ENST00000515005#MH1 Family DBDs#$#ENSP00000441954#ENSG00000113658#ENST00000545279#MH1 Family DBDs#IRF-3, MH2$#ENSP00000427474#ENSG00000113658#ENST00000507637#MH1 Family DBDs#MH2 FALSE 1692 ENSG00000137834 SMAD6 SMAD No Unlikely to be sequence specific TF Not a DNA binding protein No motif Only known motifs are from Transfac or HocoMoco - origin is uncertain In the inhibitory Smads, Smad6 and Smad7 and DAD, the MH1 domains are replaced by divergent amino-termini that share regions of similarity within the inhibitory Smad subgroup (PMID: 11532220). IPR001132;IPR003619;IPR008984;IPR013019 4091 SMAD family member 6 [Source:HGNC Symbol;Acc:HGNC:6772] None Full not tested None pmid: PMID: 16322555, a review SMAD[67] are supposed to be inhibitory SMAD:s that lack ability to bind DNA, but instead sequester RSMADs (SMAD[1235]) into non DNA-binding complexes instead of binding DNA with SMAD4 x Yes No No 2a1, Lower confidence direct evidence Jussi Taipale Pratyush Das Yes $#ENSG00000137834#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002 $#ENSP00000288840#ENSG00000137834#ENST00000288840#MH1 Family DBDs#MH2$#ENSP00000452694#ENSG00000137834#ENST00000558937#MH1 Family DBDs# FALSE 1693 ENSG00000101665 SMAD7 SMAD No Unlikely to be sequence specific TF Not a DNA binding protein No motif Only known motifs are from Transfac or HocoMoco - origin is uncertain In the inhibitory Smads, Smad6 and Smad7 and DAD, the MH1 domains are replaced by divergent amino-termini that share regions of similarity within the inhibitory Smad subgroup (PMID: 11532220). IPR001132;IPR003619;IPR008984;IPR013019 4092 SMAD family member 7 [Source:HGNC Symbol;Acc:HGNC:6773] None Full not tested None pmid: PMID: 16322555, a review SMAD[67] are supposed to be inhibitory SMAD:s that lack ability to bind DNA, but instead sequester RSMADs (SMAD[1235]) into non DNA-binding complexes instead of binding DNA with SMAD4 x Yes TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:12408818 Yes 2a1, Lower confidence direct evidence Pratyush Das Tim Hughes Yes $#ENSG00000101665#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002$#ENSG00000101665#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:17438144 $#ENSP00000262158#ENSG00000101665#ENST00000262158#MH1 Family DBDs#MH2$#ENSP00000465590#ENSG00000101665#ENST00000586093#MH1 Family DBDs#MH2$#ENSP00000466902#ENSG00000101665#ENST00000591805#MH1 Family DBDs#MH2$#ENSP00000467621#ENSG00000101665#ENST00000589634#MH1 Family DBDs#MH2 FALSE 1694 ENSG00000120693 SMAD9 SMAD Yes Known motif Obligate heteromer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain None IPR001132;IPR003619;IPR008984;IPR013019 4093 SMAD family member 9 [Source:HGNC Symbol;Acc:HGNC:6774] None DBD and Full not tested Heterodimerizes with SMAD4 pmid: PMID: 16322555, a review SMAD[1235] are supposed to be SMAD:s that bind DNA with SMAD4 as heteromultimers a Yes TF Gene_Transcription Factor Binding: tf co-factor binding; DNA-Binding: sequence-specific_Co-activation_PMIDS:10814522;11163184 No 2a1, Lower confidence direct evidence Tim Hughes Matt Weirauch Yes $#ENSG00000120693#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002 $#ENSP00000239885#ENSG00000120693#ENST00000350148#MH1 Family DBDs#IRF-3, MH2$#ENSP00000382216#ENSG00000120693#ENST00000399275#MH1 Family DBDs#IRF-3, MH2$#ENSP00000369154#ENSG00000120693#ENST00000379826#MH1 Family DBDs#IRF-3, MH2 FALSE 1695 ENSG00000115415 STAT1 STAT Yes Known motif Monomer or homomultimer In vivo/Misc source None Structure PDB:1BF5 is Tyrosine phosphorylated IPR000980;IPR008967;IPR013799;IPR013800;IPR013801;IPR015988;IPR022752; 6772 signal transducer and activator of transcription 1 [Source:HGNC Symbol;Acc:HGNC:11362] 1BF5 DBD and Full not tested Requires_Phosphorylation None a Yes TF Gene_DNA-Binding: sequence-specific_Transactivation_PMIDS:10820245;12859963 Yes 1a1, Direct HQ evidence Tim Hughes Jussi Taipale Yes $#ENSG00000115415#GO:0000983#RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity#IDA - PMID:21268089$#ENSG00000115415#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:10973496 $#ENSP00000354394#ENSG00000115415#ENST00000361099#STAT#SH2, STAT1_TAZ2bind, STAT_alpha, STAT_int$#ENSP00000376136#ENSG00000115415#ENST00000392322#STAT#SH2, STAT_alpha, STAT_int$#ENSP00000386244#ENSG00000115415#ENST00000409465#STAT#SH2, STAT1_TAZ2bind, STAT_alpha, STAT_int$#ENSP00000376137#ENSG00000115415#ENST00000392323#STAT#SH2, STAT_alpha, STAT_int$#ENSP00000402548#ENSG00000115415#ENST00000424722#STAT#STAT_alpha, STAT_int FALSE 1696 ENSG00000170581 STAT2 STAT Yes Known motif Monomer or homomultimer In vivo/Misc source None None IPR000980;IPR008967;IPR013799;IPR013800;IPR013801;IPR015988;IPR022756; 6773 signal transducer and activator of transcription 2 [Source:HGNC Symbol;Acc:HGNC:11363] None DBD and Full not tested Requires_Phosphorylation None a Yes No No 2a1, Lower confidence direct evidence Arttu Jolma Pratyush Das Yes $#ENSG00000170581#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002 $#ENSP00000315768#ENSG00000170581#ENST00000314128#STAT#SH2, STAT2_C, STAT_alpha, STAT_int$#ENSP00000387354#ENSG00000170581#ENST00000418572#STAT#STAT_alpha, STAT_int$#ENSP00000450751#ENSG00000170581#ENST00000557235#STAT#SH2, STAT2_C, STAT_alpha, STAT_int FALSE 1697 ENSG00000168610 STAT3 STAT Yes Known motif Monomer or homomultimer In vivo/Misc source None None IPR000980;IPR008967;IPR013799;IPR013800;IPR013801;IPR015988 6774 signal transducer and activator of transcription 3 [Source:HGNC Symbol;Acc:HGNC:11364] 1BG1 DBD and Full not tested Requires_Phosphorylation None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:8530402;10458605 Yes 1a1, Direct HQ evidence Arttu Jolma Pratyush Das Yes $#ENSG00000168610#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IMP - PMID:16946298$#ENSG00000168610#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IDA - PMID:16835372$#ENSG00000168610#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:17344214$#ENSG00000168610#GO:0004879#ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity#IDA - PMID:17324931 $#ENSP00000264657#ENSG00000168610#ENST00000264657#STAT#SH2, STAT_alpha, STAT_int$#ENSP00000384943#ENSG00000168610#ENST00000404395#STAT#SH2, STAT_alpha, STAT_int$#ENSP00000467985#ENSG00000168610#ENST00000588969#STAT#SH2, STAT_alpha, STAT_int$#ENSP00000373923#ENSG00000168610#ENST00000389272#STAT#SH2, STAT_alpha FALSE 1698 ENSG00000138378 STAT4 STAT Yes Known motif Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain None IPR000980;IPR008967;IPR013799;IPR013800;IPR013801;IPR015155;IPR015988; 6775 signal transducer and activator of transcription 4 [Source:HGNC Symbol;Acc:HGNC:11365] None DBD and Full not tested Requires_Phosphorylation None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:12372421;17304212 Yes 1a1, Direct HQ evidence Jussi Taipale Matt Weirauch Yes $#ENSG00000138378#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002 $#ENSP00000351255#ENSG00000138378#ENST00000358470#STAT#SH2, STAT_alpha, STAT_int$#ENSP00000376134#ENSG00000138378#ENST00000392320#STAT#SH2, STAT_alpha, STAT_int$#ENSP00000412397#ENSG00000138378#ENST00000450994#STAT#STAT_int FALSE 1699 ENSG00000126561 STAT5A STAT Yes Known motif Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain None IPR000980;IPR008967;IPR013799;IPR013800;IPR013801;IPR015988 6776 signal transducer and activator of transcription 5A [Source:HGNC Symbol;Acc:HGNC:11366] None DBD and Full not tested Requires_Phosphorylation None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:12393611 Yes 2a1, Lower confidence direct evidence Tim Hughes Yimeng Yin Yes $#ENSG00000126561#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002 $#ENSP00000341208#ENSG00000126561#ENST00000345506#STAT#SH2, STAT_alpha, STAT_int$#ENSP00000443107#ENSG00000126561#ENST00000546010#STAT#SH2, STAT_alpha, STAT_int$#ENSP00000466320#ENSG00000126561#ENST00000587646#STAT#SH2$#ENSP00000465437#ENSG00000126561#ENST00000588868#STAT#SH2, STAT_alpha, STAT_int$#ENSP00000468749#ENSG00000126561#ENST00000590949#STAT#SH2, STAT_alpha, STAT_int$#ENSP00000464730#ENSG00000126561#ENST00000590726#STAT#STAT_alpha FALSE 1700 ENSG00000173757 STAT5B STAT Yes Known motif Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain Can form both homodimers and heterodimers with STAT5A (PMID: 9528750) IPR000980;IPR008967;IPR013799;IPR013800;IPR013801;IPR015988 6777 signal transducer and activator of transcription 5B [Source:HGNC Symbol;Acc:HGNC:11367] None DBD not tested Requires_Phosphorylation None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:9852045;12050218 Yes 2a1, Lower confidence direct evidence Jussi Taipale Arttu Jolma Yes $#ENSG00000173757#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000173757#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:8631883 $#ENSP00000293328#ENSG00000173757#ENST00000293328#STAT#SH2, STAT_alpha, STAT_int$#ENSP00000398379#ENSG00000173757#ENST00000415845#STAT#STAT_int, TerB_N FALSE 1701 ENSG00000166888 STAT6 STAT Yes Known motif Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain None IPR000980;IPR008967;IPR013799;IPR013800;IPR013801;IPR015988;IPR028187; 6778 signal transducer and activator of transcription 6 [Source:HGNC Symbol;Acc:HGNC:11368] 4Y5W DBD and Full not tested Requires_Phosphorylation Requires phosphorylation a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:7760829;8810328 Yes 1a1, Direct HQ evidence Pratyush Das Jussi Taipale Yes $#ENSG00000166888#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019 $#ENSP00000300134#ENSG00000166888#ENST00000300134#STAT#SH2, STAT6_C, STAT_alpha$#ENSP00000451742#ENSG00000166888#ENST00000556155#STAT#SH2, STAT6_C, STAT_alpha$#ENSP00000401486#ENSG00000166888#ENST00000454075#STAT#SH2, STAT6_C, STAT_alpha$#ENSP00000444530#ENSG00000166888#ENST00000537215#STAT#SH2, STAT6_C, STAT_alpha$#ENSP00000445409#ENSG00000166888#ENST00000538913#STAT#SH2, STAT6_C, STAT_alpha$#ENSP00000438451#ENSG00000166888#ENST00000543873#STAT#SH2, STAT6_C, STAT_alpha$#ENSP00000450732#ENSG00000166888#ENST00000553275#STAT#STAT_int$#ENSP00000451546#ENSG00000166888#ENST00000553533#STAT#SH2$#ENSP00000450428#ENSG00000166888#ENST00000555318#STAT#STAT6_C$#ENSP00000450921#ENSG00000166888#ENST00000555375#STAT#SH2$#ENSP00000452373#ENSG00000166888#ENST00000556259#STAT#STAT_int FALSE 1702 ENSG00000163508 EOMES T-box Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001699;IPR008967;IPR018186; 8320 eomesodermin [Source:HGNC Symbol;Acc:HGNC:3372] None DBD Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_Transactivation_PMIDS:8978604;11585801 No 1a1, Direct HQ evidence Matt Weirauch Pratyush Das Yes $#ENSG00000163508#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002 $#ENSP00000295743#ENSG00000163508#ENST00000295743#T-box#T-box_assoc$#ENSP00000388620#ENSG00000163508#ENST00000449599#T-box#T-box_assoc$#ENSP00000487112#ENSG00000163508#ENST00000461503#T-box#T-box_assoc FALSE 1703 ENSG00000174197 MGA T-box Yes Known motif Monomer or homomultimer High-throughput in vitro Has a putative AT-hook Some isoforms also contain a predicted bHLH domain, but it is unlike any other known bHLH domain and the MGA motif looks like a standard T-box motif, so the bHLH domain is likely a false positive IPR001699;IPR008967;IPR011598;IPR018186 23269 MGA, MAX dimerization protein [Source:HGNC Symbol;Acc:HGNC:14010] None DBD Yes None None b Yes No No 1a1, Direct HQ evidence Pratyush Das Laura Campitelli Yes $#ENSG00000174197#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002 $#ENSP00000457151#ENSG00000174197#ENST00000563576#T-box#DUF4801$#ENSP00000456141#ENSG00000174197#ENST00000566586#T-box#DUF4801$#ENSP00000483990#ENSG00000174197#ENST00000619521#T-box#$#ENSP00000457474#ENSG00000174197#ENST00000564190#T-box#$#ENSP00000455155#ENSG00000174197#ENST00000566718#T-box#DUF4801 FALSE 1704 ENSG00000164458 T T-box Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001699;IPR002070;IPR008967;IPR018186 6862 T brachyury transcription factor [Source:HGNC Symbol;Acc:HGNC:11515] 1XBR DBD and Full not tested None None a Yes TF Gene_DNA-Binding: sequence-specific_Transactivation_PMIDS:7588606;8344258 Yes 1a1, Direct HQ evidence Pratyush Das Arttu Jolma Yes $#ENSG00000164458#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:8963900$#ENSG00000164458#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#IDA - PMID:21632880 $#ENSP00000355836#ENSG00000164458#ENST00000366871#T-box#$#ENSP00000355841#ENSG00000164458#ENST00000366876#T-box#$#ENSP00000296946#ENSG00000164458#ENST00000296946#T-box#$#ENSP00000453512#ENSG00000164458#ENST00000461348#T-box# FALSE 1705 ENSG00000136535 TBR1 T-box Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001699;IPR008967;IPR018186; 10716 T-box, brain 1 [Source:HGNC Symbol;Acc:HGNC:11590] None DBD and Full Yes None None b Yes TF Gene_Transcription Factor Binding: tf co-factor binding; DNA-Binding: sequence-specific_DNA Binding_PMIDS:10749215;11239428;15634788 Yes 1a1, Direct HQ evidence Sam Lambert Yimeng Yin Yes $#ENSG00000136535#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019 $#ENSP00000374205#ENSG00000136535#ENST00000389554#T-box#T-box_assoc$#ENSP00000387023#ENSG00000136535#ENST00000410035#T-box#T-box_assoc$#ENSP00000393934#ENSG00000136535#ENST00000411412#T-box#T-box_assoc FALSE 1706 ENSG00000184058 TBX1 T-box Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001699;IPR008967;IPR018186; 6899 T-box 1 [Source:HGNC Symbol;Acc:HGNC:11592] 4A04 DBD Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:11111039;15736267 No 1a1, Direct HQ evidence Jussi Taipale Laura Campitelli Yes $#ENSG00000184058#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:11111039 $#ENSP00000331176#ENSG00000184058#ENST00000329705#T-box#$#ENSP00000331791#ENSG00000184058#ENST00000332710#T-box#$#ENSP00000352483#ENSG00000184058#ENST00000359500#T-box#$#ENSP00000477982#ENSG00000184058#ENST00000621939#T-box# FALSE 1707 ENSG00000167800 TBX10 T-box Yes Inferred motif Monomer or homomultimer High-throughput in vitro None None IPR001699;IPR008967;IPR018186; 347853 T-box 10 [Source:HGNC Symbol;Acc:HGNC:11593] None DBD and Full not tested None None a Yes No No 1a2, Orthologous HQ evidence Pratyush Das Yimeng Yin Yes $#ENSG00000167800#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002 $#ENSP00000335191#ENSG00000167800#ENST00000335385#T-box# FALSE 1708 ENSG00000092607 TBX15 T-box Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001699;IPR008967;IPR018186; 6913 T-box 15 [Source:HGNC Symbol;Acc:HGNC:11594] None DBD and Full not tested None None b Yes Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0 Yes 1a1, Direct HQ evidence Yimeng Yin Pratyush Das Yes $#ENSG00000092607#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019 $#ENSP00000207157#ENSG00000092607#ENST00000207157#T-box#$#ENSP00000358437#ENSG00000092607#ENST00000369429#T-box#$#ENSP00000398625#ENSG00000092607#ENST00000449873#T-box# FALSE 1709 ENSG00000112837 TBX18 T-box Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001699;IPR008967;IPR018186; 9096 T-box 18 [Source:HGNC Symbol;Acc:HGNC:11595] None DBD and Full not tested None None b Yes Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0 No 1a1, Direct HQ evidence Pratyush Das Matt Weirauch Yes $#ENSG00000112837#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002 $#ENSP00000358677#ENSG00000112837#ENST00000369663#T-box#$#ENSP00000475873#ENSG00000112837#ENST00000606784#T-box#$#ENSP00000476137#ENSG00000112837#ENST00000606621#T-box#$#ENSP00000475498#ENSG00000112837#ENST00000606325#T-box# FALSE 1710 ENSG00000143178 TBX19 T-box Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001699;IPR002070;IPR008967;IPR018186 9095 T-box 19 [Source:HGNC Symbol;Acc:HGNC:11596] None DBD and Full not tested None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:11290323 No 1a1, Direct HQ evidence Arttu Jolma Pratyush Das Yes $#ENSG00000143178#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019 $#ENSP00000356795#ENSG00000143178#ENST00000367821#T-box#$#ENSP00000390731#ENSG00000143178#ENST00000441464#T-box#$#ENSP00000397540#ENSG00000143178#ENST00000431969#T-box# FALSE 1711 ENSG00000121068 TBX2 T-box Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001699;IPR002070;IPR008967;IPR018186;IPR022582; 6909 T-box 2 [Source:HGNC Symbol;Acc:HGNC:11597] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:11111039 Yes 1a1, Direct HQ evidence Jussi Taipale Tim Hughes Yes $#ENSG00000121068#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:11111039 $#ENSP00000240328#ENSG00000121068#ENST00000240328#T-box#TBX FALSE 1712 ENSG00000164532 TBX20 T-box Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001699;IPR008967;IPR018186; 57057 T-box 20 [Source:HGNC Symbol;Acc:HGNC:11598] None DBD and Full Yes None None b Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:15843407 No 1a1, Direct HQ evidence Jussi Taipale Arttu Jolma Yes $#ENSG00000164532#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019 $#ENSP00000386170#ENSG00000164532#ENST00000408931#T-box# FALSE 1713 ENSG00000073861 TBX21 T-box Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001699;IPR008967;IPR018186; 30009 T-box 21 [Source:HGNC Symbol;Acc:HGNC:11599] None DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:10761931;15662016;16275766 Yes 1a1, Direct HQ evidence Jussi Taipale Tim Hughes Yes $#ENSG00000073861#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:10761931 $#ENSP00000177694#ENSG00000073861#ENST00000177694#T-box# FALSE 1714 ENSG00000122145 TBX22 T-box Yes Known motif Monomer or homomultimer In vivo/Misc source None None IPR001699;IPR008967;IPR018186; 50945 T-box 22 [Source:HGNC Symbol;Acc:HGNC:11600] None DBD and Full not tested None None b Yes TF Gene Candidate__Other_PMIDS:12374769 No 2a1, Lower confidence direct evidence Yimeng Yin Laura Campitelli Yes $#ENSG00000122145#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:11024289 $#ENSP00000362390#ENSG00000122145#ENST00000373294#T-box#$#ENSP00000362393#ENSG00000122145#ENST00000373296#T-box# FALSE 1715 ENSG00000135111 TBX3 T-box Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001699;IPR002070;IPR008967;IPR018186;IPR022582; 6926 T-box 3 [Source:HGNC Symbol;Acc:HGNC:11602] 1H6F DBD and Full Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:11689487;12005433 Yes 1a1, Direct HQ evidence Arttu Jolma Sam Lambert Yes $#ENSG00000135111#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:11689487 $#ENSP00000257566#ENSG00000135111#ENST00000257566#T-box#TBX$#ENSP00000257567#ENSG00000135111#ENST00000349155#T-box#TBX FALSE 1716 ENSG00000121075 TBX4 T-box Yes Known motif Monomer or homomultimer High-throughput in vitro None Available motifs suggest facultative homodimeric binding IPR001699;IPR002070;IPR008967;IPR018186 9496 T-box 4 [Source:HGNC Symbol;Acc:HGNC:11603] None DBD and Full Yes None None a Yes Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0; Yes 1a1, Direct HQ evidence Pratyush Das Laura Campitelli Yes $#ENSG00000121075#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:10945475 $#ENSP00000240335#ENSG00000121075#ENST00000240335#T-box#$#ENSP00000377435#ENSG00000121075#ENST00000393853#T-box#$#ENSP00000467588#ENSG00000121075#ENST00000589003#T-box# FALSE 1717 ENSG00000089225 TBX5 T-box Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001699;IPR008967;IPR018186; 6910 T-box 5 [Source:HGNC Symbol;Acc:HGNC:11604] 2X6V DBD Yes None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:11555635 Yes 1a1, Direct HQ evidence Sam Lambert Matt Weirauch Yes $#ENSG00000089225#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IEA - GO_REF:0000019$#ENSG00000089225#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:11431700, PMID:12499378, PMID:16332960 $#ENSP00000309913#ENSG00000089225#ENST00000310346#T-box#$#ENSP00000337723#ENSG00000089225#ENST00000349716#T-box#$#ENSP00000384152#ENSG00000089225#ENST00000405440#T-box#$#ENSP00000433292#ENSG00000089225#ENST00000526441#T-box# FALSE 1718 ENSG00000149922 TBX6 T-box Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR001699;IPR002070;IPR008967;IPR018186 6911 T-box 6 [Source:HGNC Symbol;Acc:HGNC:11605] None DBD and Full not tested None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:15986483 No 1a1, Direct HQ evidence Sam Lambert Laura Campitelli Yes $#ENSG00000149922#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002 $#ENSP00000279386#ENSG00000149922#ENST00000279386#T-box#$#ENSP00000378650#ENSG00000149922#ENST00000395224#T-box#$#ENSP00000461223#ENSG00000149922#ENST00000553607#T-box#$#ENSP00000485762#ENSG00000149922#ENST00000627355#T-box# FALSE 1719 ENSG00000112592 TBP TBP Yes Known motif Monomer or homomultimer 100 perc ID - in vitro None Binds DNA in the pre-initiation complex IPR000814;IPR030491 6908 TATA-box binding protein [Source:HGNC Symbol;Acc:HGNC:11588] 1CDW not tested Yes None None No Yes No No 1a1, Direct HQ evidence Arttu Jolma Sam Lambert Yes $#ENSG00000112592#GO:0001034#sequence-specific DNA binding RNA polymerase III transcription factor activity#IMP - PMID:26638071 $#ENSP00000230354#ENSG00000112592#ENST00000230354#TBP#DDHD, DUF4746, EPL1, MMR1, Presenilin$#ENSP00000375942#ENSG00000112592#ENST00000392092#TBP#DDHD, DUF4746, EPL1, MMR1, Presenilin$#ENSP00000400008#ENSG00000112592#ENST00000421512#TBP#DDHD, DUF4746, EPL1, MMR1, Presenilin, SpoIIP, TFI$#ENSP00000442132#ENSG00000112592#ENST00000540980#TBP#DDHD, EPL1, MMR1, Presenilin$#ENSP00000416482#ENSG00000112592#ENST00000423353#TBP#DUF4746, SpoIIP, TFIIA FALSE 1720 ENSG00000028839 TBPL1 TBP Yes Likely to be sequence specific TF Obligate heteromer No motif None A more distant paralog of TBP and the only member of the TBP family that lacks the ability to bind the TATA box. (PMID: 21711503). In vitro, purified TLF-TFIIA binds directly to the NF1 promoter (PMID: 15767669), so likely an obligate heteromer. IPR000814; 9519 TATA-box binding protein like 1 [Source:HGNC Symbol;Acc:HGNC:11589] None not tested Yes None None No Yes TF Gene Candidate_DNA-Binding: sequence-specific_Other_PMIDS:11352070;15767669 No 4a, two or more datasets predict it as a TF Laura Campitelli Tim Hughes Yes None $#ENSP00000237264#ENSG00000028839#ENST00000237264#TBP#$#ENSP00000356845#ENSG00000028839#ENST00000367871#TBP#$#ENSP00000478795#ENSG00000028839#ENST00000613034#TBP#$#ENSP00000356843#ENSG00000028839#ENST00000367869#TBP#$#ENSP00000402864#ENSG00000028839#ENST00000416965#TBP# FALSE 1721 ENSG00000182521 TBPL2 TBP Yes Inferred motif Monomer or homomultimer High-throughput in vitro None None IPR000814;IPR030491 387332 TATA-box binding protein like 2 [Source:HGNC Symbol;Acc:HGNC:19841] None not tested not tested None None No Yes No No 1a2, Orthologous HQ evidence Yimeng Yin Arttu Jolma Yes $#ENSG00000182521#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019 $#ENSP00000247219#ENSG00000182521#ENST00000247219#TBP#$#ENSP00000451597#ENSG00000182521#ENST00000556755#TBP# FALSE 1722 ENSG00000189308 LIN54 TCR/CxC Yes Inferred motif Monomer or homomultimer High-throughput in vitro None In the structure (PDB: 5FD3), the protein contacts DNA, although it only contacts the backbone except for one tyrosine residue IPR005172; 132660 lin-54 DREAM MuvB core complex component [Source:HGNC Symbol;Acc:HGNC:25397] 5FD3 not tested not tested None Structure appears to contact essentially only the backbone except for one tyrosine residue, presumably non- or low specificity interaction No Yes No No 3a, decent circumstantial evidence for its role as Pratyush Das Arttu Jolma No None $#ENSP00000341947#ENSG00000189308#ENST00000340417#CxC#$#ENSP00000398265#ENSG00000189308#ENST00000442461#CxC#$#ENSP00000407139#ENSG00000189308#ENST00000446851#CxC#$#ENSP00000423475#ENSG00000189308#ENST00000506560#CxC#$#ENSP00000421045#ENSG00000189308#ENST00000510557#CxC# FALSE 1723 ENSG00000132749 TESMIN TCR/CxC No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Has a double CxC DBD structure. One is eroded, and it did not produce a motif on PBMs. So, either it has lost its ability to bind DNA, or the experiment failed for some reason. IPR005172; 9633 testis expressed metallothionein like protein [Source:HGNC Symbol;Acc:HGNC:7446] None not tested Yes None None No Yes No No 5a, one of the source datasets predicts is as a TF Matt Weirauch Tim Hughes No None $#ENSP00000255087#ENSG00000132749#ENST00000255087#CxC#$#ENSP00000440968#ENSG00000132749#ENST00000544963#CxC#$#ENSP00000403086#ENSG00000132749#ENST00000443940#CxC#$#ENSP00000454311#ENSG00000132749#ENST00000543240#CxC# FALSE 1724 ENSG00000110244 APOA4 TEA No Unlikely to be sequence specific TF Not a DNA binding protein No motif None APOA4 is Apolipoprotein A4. It consists entirely of Apolipoprotein A1/A4/E domains. The protein product is excluded from the nucleus. I cant see that it has a TEA domain. I believe it is likely to be a low-scoring domain match that almost certainly overlaps with a known domain related to its function as an enzyme. Thus it is unlikely to be a DNA binding protein. IPR000074 337 apolipoprotein A4 [Source:HGNC Symbol;Acc:HGNC:602] None not tested not tested None None No Yes No No 5a, one of the source datasets predicts is as a TF Matt Weirauch Pratyush Das No None $#ENSP00000350425#ENSG00000110244#ENST00000357780#TEA#ApoLp-III, ApoO, Baculo_PEP_C, DUF1664, KapB FALSE 1725 ENSG00000187079 TEAD1 TEA Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000818;IPR016361 7003 TEA domain transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:11714] None DBD and Full not tested None None a Yes No No 1a1, Direct HQ evidence Jussi Taipale Sam Lambert Yes $#ENSG00000187079#GO:0000982#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IMP - PMID:26045994$#ENSG00000187079#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:18579750, PMID:19324877 $#ENSP00000334754#ENSG00000187079#ENST00000334310#TEA#$#ENSP00000435393#ENSG00000187079#ENST00000526600#TEA#$#ENSP00000435233#ENSG00000187079#ENST00000527636#TEA#$#ENSP00000432587#ENSG00000187079#ENST00000527376#TEA# FALSE 1726 ENSG00000074219 TEAD2 TEA Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000818;IPR016361 8463 TEA domain transcription factor 2 [Source:HGNC Symbol;Acc:HGNC:11715] None DBD and Full not tested None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:11279002 Yes 1a1, Direct HQ evidence Laura Campitelli Jussi Taipale Yes $#ENSG00000074219#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:18579750, PMID:19324877 | NAS - PMID:87$#ENSG00000074219#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019 $#ENSP00000310701#ENSG00000074219#ENST00000311227#TEA#$#ENSP00000469640#ENSG00000074219#ENST00000593945#TEA#$#ENSP00000472109#ENSG00000074219#ENST00000598810#TEA#$#ENSP00000469672#ENSG00000074219#ENST00000601519#TEA#$#ENSP00000366419#ENSG00000074219#ENST00000377214#TEA#$#ENSP00000437928#ENSG00000074219#ENST00000539846#TEA# FALSE 1727 ENSG00000007866 TEAD3 TEA Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000818;IPR016361;IPR027253; 7005 TEA domain transcription factor 3 [Source:HGNC Symbol;Acc:HGNC:11716] None DBD and Full not tested None None a Yes No No 1a1, Direct HQ evidence Yimeng Yin Pratyush Das Yes $#ENSG00000007866#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:18579750, PMID:19324877 $#ENSP00000345772#ENSG00000007866#ENST00000338863#TEA#$#ENSP00000384577#ENSG00000007866#ENST00000402886#TEA#$#ENSP00000416400#ENSG00000007866#ENST00000433586#TEA# FALSE 1728 ENSG00000197905 TEAD4 TEA Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR000818;IPR016361;IPR027255; 7004 TEA domain transcription factor 4 [Source:HGNC Symbol;Acc:HGNC:11717] None DBD and Full not tested None None a Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:8631987 No 1a1, Direct HQ evidence Jussi Taipale Arttu Jolma Yes $#ENSG00000197905#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:18579750, PMID:19324877 $#ENSP00000351184#ENSG00000197905#ENST00000358409#TEA#$#ENSP00000352926#ENSG00000197905#ENST00000359864#TEA#$#ENSP00000380311#ENSG00000197905#ENST00000397122#TEA# FALSE 1729 ENSG00000131931 THAP1 THAP finger Yes Known motif Monomer or homomultimer In vivo/Misc source None Likely binds as a homodimer IPR006612; 55145 THAP domain containing 1 [Source:HGNC Symbol;Acc:HGNC:20856] 2KO0 not tested not tested None None c Yes No No 1a1, Direct HQ evidence Sam Lambert Yimeng Yin Yes None $#ENSP00000254250#ENSG00000131931#ENST00000254250#THAP#ADIP, APG6, ATG16, CENP-Q, Cep57_CLD, DUF4391, MPS$#ENSP00000344966#ENSG00000131931#ENST00000345117#THAP#$#ENSP00000433912#ENSG00000131931#ENST00000529779#THAP# FALSE 1730 ENSG00000129028 THAP10 THAP finger Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Paralog THAP1 binds DNA in a sequence specific manner IPR006612; 56906 THAP domain containing 10 [Source:HGNC Symbol;Acc:HGNC:23193] None not tested not tested None None c Yes No No 4a, two or more datasets predict it as a TF Arttu Jolma Matt Weirauch Yes None $#ENSP00000249861#ENSG00000129028#ENST00000249861#THAP#$#ENSP00000453920#ENSG00000129028#ENST00000560604#THAP# FALSE 1731 ENSG00000168286 THAP11 THAP finger Yes Likely to be sequence specific TF Monomer or homomultimer No motif None (PMID: 26876175) has a ChIP-seq motif with GGGARWTGTAGT consensus. THAP11 is an atypical zinc-finger paralogous to THAP1, which has a crystal structure (PDB: 2KO0) where the protein contacts bases TGGGCA IPR006612; 57215 THAP domain containing 11 [Source:HGNC Symbol;Acc:HGNC:23194] None not tested not tested None None c Yes No No 4a, two or more datasets predict it as a TF Pratyush Das Arttu Jolma Yes None $#ENSP00000304689#ENSG00000168286#ENST00000303596#THAP#CPSF100_C, DDHD, DUF2722 FALSE 1732 ENSG00000137492 THAP12 THAP finger Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR006612;IPR008906;IPR012337;IPR025398 5612 THAP domain containing 12 [Source:HGNC Symbol;Acc:HGNC:9440] None Full Yes None None c Yes No Yes 1a1, Direct HQ evidence Matt Weirauch Pratyush Das Yes $#ENSG00000137492#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000260045#ENSG00000137492#ENST00000260045#THAP#DUF4371, Dimer_Tnp_hAT FALSE 1733 ENSG00000173451 THAP2 THAP finger Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR006612; 83591 THAP domain containing 2 [Source:HGNC Symbol;Acc:HGNC:20854] None not tested not tested None None c Yes No No 4a, two or more datasets predict it as a TF Sam Lambert Pratyush Das Yes None $#ENSP00000310796#ENSG00000173451#ENST00000308086#THAP#$#ENSP00000449826#ENSG00000173451#ENST00000547843#THAP#$#ENSP00000446986#ENSG00000173451#ENST00000551238#THAP#$#ENSP00000448904#ENSG00000173451#ENST00000551488#THAP# FALSE 1734 ENSG00000041988 THAP3 THAP finger Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR006612; 90326 THAP domain containing 3 [Source:HGNC Symbol;Acc:HGNC:20855] None not tested not tested None None c Yes No No 4a, two or more datasets predict it as a TF Arttu Jolma Tim Hughes Yes None $#ENSP00000054650#ENSG00000041988#ENST00000054650#THAP#$#ENSP00000311537#ENSG00000041988#ENST00000307896#THAP#$#ENSP00000366854#ENSG00000041988#ENST00000377627#THAP#$#ENSP00000473646#ENSG00000041988#ENST00000472925#THAP# FALSE 1735 ENSG00000176946 THAP4 THAP finger Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR006612;IPR011038;IPR014878; 51078 THAP domain containing 4 [Source:HGNC Symbol;Acc:HGNC:23187] None DBD not tested None None c Yes No No 4a, two or more datasets predict it as a TF Yimeng Yin Pratyush Das Yes None $#ENSP00000385931#ENSG00000176946#ENST00000402136#THAP#DUF1794$#ENSP00000385006#ENSG00000176946#ENST00000407315#THAP#DUF1794, DUF4201, HrpB7$#ENSP00000482312#ENSG00000176946#ENST00000612200#THAP#DUF1794, DUF4201, HrpB7, IncA$#ENSP00000384352#ENSG00000176946#ENST00000402545#THAP#DUF1794 FALSE 1736 ENSG00000177683 THAP5 THAP finger Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR006612; 168451 THAP domain containing 5 [Source:HGNC Symbol;Acc:HGNC:23188] None not tested not tested None None c Yes No No 4a, two or more datasets predict it as a TF Sam Lambert Pratyush Das Yes None $#ENSP00000322440#ENSG00000177683#ENST00000313516#THAP#ADIP$#ENSP00000400500#ENSG00000177683#ENST00000415914#THAP#ADIP$#ENSP00000415841#ENSG00000177683#ENST00000438865#THAP# FALSE 1737 ENSG00000174796 THAP6 THAP finger Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR006612; 152815 THAP domain containing 6 [Source:HGNC Symbol;Acc:HGNC:23189] None not tested not tested None None c Yes No No 4a, two or more datasets predict it as a TF Sam Lambert Pratyush Das Yes None $#ENSP00000309007#ENSG00000174796#ENST00000311638#THAP#DUF4686$#ENSP00000370217#ENSG00000174796#ENST00000380837#THAP#$#ENSP00000426581#ENSG00000174796#ENST00000504190#THAP#$#ENSP00000424255#ENSG00000174796#ENST00000507885#THAP#$#ENSP00000426760#ENSG00000174796#ENST00000508105#THAP#$#ENSP00000423720#ENSG00000174796#ENST00000514480#THAP#DUF4686$#ENSP00000427651#ENSG00000174796#ENST00000507556#THAP#$#ENSP00000426698#ENSG00000174796#ENST00000502620#THAP#$#ENSP00000422402#ENSG00000174796#ENST00000506261#THAP# FALSE 1738 ENSG00000184436 THAP7 THAP finger Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR006612; 80764 THAP domain containing 7 [Source:HGNC Symbol;Acc:HGNC:23190] None not tested not tested None None c Yes No No 4a, two or more datasets predict it as a TF Yimeng Yin Arttu Jolma Yes None $#ENSP00000215742#ENSG00000184436#ENST00000215742#THAP#$#ENSP00000382084#ENSG00000184436#ENST00000399133#THAP# FALSE 1739 ENSG00000161277 THAP8 THAP finger Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None IPR006612; 199745 THAP domain containing 8 [Source:HGNC Symbol;Acc:HGNC:23191] None Full not tested None None c Yes No No 4a, two or more datasets predict it as a TF Pratyush Das Yimeng Yin Yes None $#ENSP00000292894#ENSG00000161277#ENST00000292894#THAP# FALSE 1740 ENSG00000168152 THAP9 THAP finger Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Human THAP9 Gene Encodes an Active P-Element DNA Transposase (PMID: 23349291) IPR006612; 79725 THAP domain containing 9 [Source:HGNC Symbol;Acc:HGNC:23192] None not tested not tested None None c Yes No No 4a, two or more datasets predict it as a TF Sam Lambert Yimeng Yin Yes None $#ENSP00000305533#ENSG00000168152#ENST00000302236#THAP#Tnp_P_element FALSE 1741 ENSG00000275700 AATF Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Likely does not bind to bind to DNA (PMID: 17634135). IPR012617;IPR025160 26574 apoptosis antagonizing transcription factor [Source:HGNC Symbol;Acc:HGNC:19235] None not tested not tested None None No No TF Gene Candidate__Transactivation_PMIDS:14627703 No 5a, one of the source datasets predicts is as a TF Pratyush Das Arttu Jolma No $#ENSG00000275700#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019 $##ENSG00000275700##Other# FALSE 1742 ENSG00000097007 ABL1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None None 25 ABL proto-oncogene 1, non-receptor tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:76] None not tested not tested None None No No No No 2a1, Lower confidence direct evidence Sam Lambert Yimeng Yin No None $##ENSG00000097007##Other# FALSE 1743 ENSG00000174429 ABRA Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None The Costars domain in this protein is an atypical winged helix protein that does not bind DNA but to other proteins (PMID: 21082705) IPR027817 137735 actin binding Rho activating protein [Source:HGNC Symbol;Acc:HGNC:30655] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Arttu Jolma Sam Lambert No $#ENSG00000174429#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024 $#ENSP00000311436#ENSG00000174429#ENST00000311955#Other#Costars FALSE 1744 ENSG00000142396 AC020915.1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None None None endogenous retrovirus group K3 member 1 [Source:HGNC Symbol;Acc:HGNC:30466] None not tested not tested None None b No No No 5a, one of the source datasets predicts is as a TF Pratyush Das Arttu Jolma No None $#ENSP00000489018#ENSG00000142396#ENST00000413518#Other#HERV-K_REC$#ENSP00000488921#ENSG00000142396#ENST00000427361#Other#HERV-K_REC FALSE 1745 ENSG00000102794 ACOD1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR005656 730249 aconitate decarboxylase 1 [Source:HGNC Symbol;Acc:HGNC:33904] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Laura Campitelli Sam Lambert No $#ENSG00000102794#GO:0032088#negative regulation of NF-kappaB transcription factor activity#ISS - GO_REF:0000024 $#ENSP00000401584#ENSG00000102794#ENST00000449753#Other#MmgE_PrpD$#ENSP00000366682#ENSG00000102794#ENST00000377462#Other#MmgE_PrpD FALSE 1746 ENSG00000133627 ACTR3B Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR004000;IPR020902 57180 ARP3 actin-related protein 3 homolog B (yeast) [Source:HGNC Symbol;Acc:HGNC:17256] None not tested not tested None Has no DBDs No No No No 5a, one of the source datasets predicts is as a TF Tim Hughes Sam Lambert No None $#ENSP00000256001#ENSG00000133627#ENST00000256001#Other#Actin, FtsA, MreB_Mbl$#ENSP00000367007#ENSG00000133627#ENST00000377776#Other#Actin, FtsA, MreB_Mbl$#ENSP00000380452#ENSG00000133627#ENST00000397282#Other#Actin, FtsA, MreB_Mbl FALSE 1747 ENSG00000106526 ACTR3C Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Pfam match to an APSES domain - this is likely a false positive, as these domains are mostly present in bacteria and fungi IPR004000; 653857 ARP3 actin-related protein 3 homolog C [Source:HGNC Symbol;Acc:HGNC:37282] None not tested Yes None Has no DBDs No Yes No No 5a, one of the source datasets predicts is as a TF Laura Campitelli Sam Lambert No None $#ENSP00000252071#ENSG00000106526#ENST00000252071#Other#Actin, FtsA$#ENSP00000417426#ENSG00000106526#ENST00000478393#Other#Actin$#ENSP00000418635#ENSG00000106526#ENST00000477871#Other#Actin$#ENSP00000481447#ENSG00000106526#ENST00000613959#Other# FALSE 1748 ENSG00000151651 ADAM8 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000742;IPR001590;IPR001762;IPR002870;IPR006586;IPR013032;IPR018358 101 ADAM metallopeptidase domain 8 [Source:HGNC Symbol;Acc:HGNC:215];Disintegrin and metalloproteinase d None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Laura Campitelli Sam Lambert No $#ENSG00000151651#GO:0051092#positive regulation of NF-kappaB transcription factor activity#ISS - GO_REF:0000024 $#ENSP00000453855#ENSG00000151651#ENST00000415217#Other#ADAM_CR, Disintegrin, EGF_2, Pep_M12B_propep, Repr$#ENSP00000453302#ENSG00000151651#ENST00000445355#Other#ADAM_CR, Disintegrin, EGF_2, Pep_M12B_propep, Repr$#ENSP00000453043#ENSG00000151651#ENST00000485491#Other#ADAM_CR, Disintegrin, Reprolysin, Reprolysin_2, Re$#ENSP00000453735#ENSG00000151651#ENST00000486609#Other#Pep_M12B_propep FALSE 1749 ENSG00000140470 ADAMTS17 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000884;IPR001590;IPR002870;IPR006586;IPR007087;IPR010294;IPR010909;IPR013273 170691 ADAM metallopeptidase with thrombospondin type 1 motif 17 [Source:HGNC Symbol;Acc:HGNC:17109] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Yimeng Yin Pratyush Das No None $#ENSP00000268070#ENSG00000140470#ENST00000268070#Other#ADAM_spacer1, PLAC, Pep_M12B_propep, Peptidase_M10$#ENSP00000458005#ENSG00000140470#ENST00000561355#Other#Pep_M12B_propep$#ENSP00000456161#ENSG00000140470#ENST00000568565#Other#ADAM_spacer1 FALSE 1750 ENSG00000145808 ADAMTS19 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif Has a putative AT-hook None IPR000884;IPR001590;IPR002870;IPR006586;IPR010294;IPR010909;IPR013273; 171019 ADAM metallopeptidase with thrombospondin type 1 motif 19 [Source:HGNC Symbol;Acc:HGNC:17111] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Jussi Taipale Matt Weirauch No None $#ENSP00000274487#ENSG00000145808#ENST00000274487#Other#ADAM_spacer1, PLAC, Pep_M12B_propep, Peptidase_M10 FALSE 1751 ENSG00000160710 ADAR Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None PMID: 21728134 shows the ADAR protein bind to ds RNA and Z DNA. At best it would be a non-sequence specific DNA binding protein. But, it has a well established role as a dsRNA binding protein, so it is unlikely to be a TF. IPR000607;IPR002466;IPR014720; 103 adenosine deaminase, RNA specific [Source:HGNC Symbol;Acc:HGNC:225] 1QBJ not tested not tested None The structure has the protein bound to double stranded dsDNA x No No No 3a, decent circumstantial evidence for its role as Pratyush Das Jussi Taipale No None $#ENSP00000357456#ENSG00000160710#ENST00000368471#Other#A_deamin, DND1_DSRM, Dicer_dimer, dsrm, z-alpha$#ENSP00000357459#ENSG00000160710#ENST00000368474#Other#A_deamin, DND1_DSRM, TrmB, dsrm, z-alpha$#ENSP00000431794#ENSG00000160710#ENST00000529168#Other#A_deamin, DND1_DSRM, TrmB, dsrm, z-alpha FALSE 1752 ENSG00000197177 ADGRA1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000832;IPR017981;IPR017983; 84435 adhesion G protein-coupled receptor A1 [Source:HGNC Symbol;Acc:HGNC:13838] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Sam Lambert Pratyush Das No None $#ENSP00000376383#ENSG00000197177#ENST00000392606#Other#7tm_2$#ENSP00000475778#ENSG00000197177#ENST00000607359#Other#7tm_2$#ENSP00000376384#ENSG00000197177#ENST00000392607#Other#7tm_2 FALSE 1753 ENSG00000182885 ADGRG3 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000203;IPR000832;IPR003910;IPR017981 222487 adhesion G protein-coupled receptor G3 [Source:HGNC Symbol;Acc:HGNC:13728] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Jussi Taipale Yimeng Yin No $#ENSG00000182885#GO:0032792#negative regulation of CREB transcription factor activity#ISS - GO_REF:0000024 $#ENSP00000332900#ENSG00000182885#ENST00000333493#Other#7tm_2, GPS$#ENSP00000404803#ENSG00000182885#ENST00000450388#Other#7tm_2, GPS FALSE 1754 ENSG00000106624 AEBP1 Unknown Yes Likely to be sequence specific TF Monomer or homomultimer No motif None This is a protease, but its ability to bind DNA is supported by both gel-shift (PMID: 15654748) and ChIP (PMID: 22723309). IPR000421;IPR000834;IPR008969;IPR008979 100616346 AE binding protein 1 [Source:HGNC Symbol;Acc:HGNC:303] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Pratyush Das Matt Weirauch No $#ENSG00000106624#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IDA - PMID:15654748 | IMP - PMID:15654748$#ENSG00000106624#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:8920928 $#ENSP00000223357#ENSG00000106624#ENST00000223357#Other#CarbopepD_reg_2, CarboxypepD_reg, F5_F8_type_C, Pe$#ENSP00000398878#ENSG00000106624#ENST00000450684#Other#CarbopepD_reg_2, CarboxypepD_reg, F5_F8_type_C, Pe$#ENSP00000401758#ENSG00000106624#ENST00000449162#Other#$#ENSP00000411277#ENSG00000106624#ENST00000455443#Other# FALSE 1755 ENSG00000104964 AES Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Likely a transcriptional co-factor IPR005617 166 amino-terminal enhancer of split [Source:HGNC Symbol;Acc:HGNC:307] None not tested not tested None None No No TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:10660609;11416139 No 5a, one of the source datasets predicts is as a TF Pratyush Das Sam Lambert No None $##ENSG00000104964##Other# FALSE 1756 ENSG00000196526 AFAP1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None There is no evidence suggesting DNA-binding activity IPR001849; 60312 actin filament associated protein 1 [Source:HGNC Symbol;Acc:HGNC:24017] None DBD not tested None None b No No No 5a, one of the source datasets predicts is as a TF Laura Campitelli Arttu Jolma No None $#ENSP00000353402#ENSG00000196526#ENST00000360265#Other#PH, PH_11, PH_9, Sharpin_PH, Spc7$#ENSP00000351245#ENSG00000196526#ENST00000358461#Other#PH, PH_11, PH_9, Sharpin_PH, Spc7$#ENSP00000410689#ENSG00000196526#ENST00000420658#Other#PH, PH_11, PH_9, Sharpin_PH$#ENSP00000483962#ENSG00000196526#ENST00000614385#Other# FALSE 1757 ENSG00000172493 AFF1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif Has a putative AT-hook MLL fusion partner IPR007797; 4299 AF4/FMR2 family member 1 [Source:HGNC Symbol;Acc:HGNC:7135] None Full not tested None None c No No Yes 4a, two or more datasets predict it as a TF Matt Weirauch Yimeng Yin No $#ENSG00000172493#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:7689231 $#ENSP00000305689#ENSG00000172493#ENST00000307808#Other#AF-4$#ENSP00000427593#ENSG00000172493#ENST00000507468#Other#AF-4$#ENSP00000378578#ENSG00000172493#ENST00000395146#Other#AF-4$#ENSP00000424483#ENSG00000172493#ENST00000503477#Other#AF-4$#ENSP00000425755#ENSG00000172493#ENST00000511442#Other#AF-4$#ENSP00000424881#ENSG00000172493#ENST00000514970#Other#AF-4 FALSE 1758 ENSG00000144218 AFF3 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None (PMID: 8555498) only says that In vitro-translated LAF-4 was able to bind strongly to double-stranded DNA cellulose - thats more consistent with nonspecific DNA binding. The key issue is whether the Transcription factor AF4/FMR2 (IPR007797) domain really is sequence specific. Most of the work has been done on the one Drosophila ortholog, lilliuputian. I see no evidence of DNA binding. Recent work on this family in human indicate that it functions in coactivation (PMID: 27899651; PMID: 261712 IPR007797; 3899 AF4/FMR2 family member 3 None not tested not tested None None other No No No 5a, one of the source datasets predicts is as a TF Pratyush Das Sam Lambert No None $#ENSP00000396582#ENSG00000144218#ENST00000423966#Other#AF-4$#ENSP00000416685#ENSG00000144218#ENST00000445815#Other#AF-4 FALSE 1759 ENSG00000072364 AFF4 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None (PMID: 8555498) only says that In vitro-translated LAF-4 was able to bind strongly to double-stranded DNA cellulose - thats more consistent with nonspecific DNA binding. The key issue is whether the Transcription factor AF4/FMR2 (IPR007797) domain really is sequence specific. Most of the work has been done on the one Drosophila ortholog, lilliuputian. I see no evidence of DNA binding. Recent work on this family in human indicate that it functions in coactivation (PMID: 27899651; PMID: 261712 IPR007797; 27125 AF4/FMR2 family member 4 [Source:HGNC Symbol;Acc:HGNC:17869] None not tested not tested None None c No No Yes 4a, two or more datasets predict it as a TF Matt Weirauch Pratyush Das No $#ENSG00000072364#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:10588740 $#ENSP00000265343#ENSG00000072364#ENST00000265343#Other#AF-4, Peptidase_S64$#ENSP00000367858#ENSG00000072364#ENST00000378595#Other#AF-4$#ENSP00000395268#ENSG00000072364#ENST00000421773#Other#AF-4$#ENSP00000409069#ENSG00000072364#ENST00000425658#Other#AF-4 FALSE 1760 ENSG00000204305 AGER Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None Contacts DNA in the structure (PDB: 4OI7) IPR003006;IPR003598;IPR003599;IPR007110;IPR013162 None advanced glycosylation end product-specific receptor [Source:HGNC Symbol;Acc:HGNC:320] 4OI7 not tested not tested None Contacts DNA in the structure (PDB: 4OI7) No No No Yes 3a, decent circumstantial evidence for its role as a TF or not Sam Lambert Pratyush Das No None None FALSE 1761 ENSG00000135744 AGT Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000227;IPR023795;IPR023796 183 angiotensinogen [Source:HGNC Symbol;Acc:HGNC:333] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Laura Campitelli Arttu Jolma No $#ENSG00000135744#GO:0051092#positive regulation of NF-kappaB transcription factor activity#TAS - PMID:17906677 $#ENSP00000355627#ENSG00000135744#ENST00000366667#Other#Serpin FALSE 1762 ENSG00000163568 AIM2 Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None Based on (PDB: 3RN2), the protein binds DNA but contacts only the backbone; AIM2 binds cytrosolic dsDNA in the innate immune response IPR004020;IPR004021;IPR011029 9447 absent in melanoma 2 [Source:HGNC Symbol;Acc:HGNC:357];Interferon-inducible protein AIM2 3RN2 not tested not tested None In the structure Non-sequence-specific DNA recognition is accomplished through electrostatic attraction between the positively charged HIN domain residues and the dsDNA sugar-phosphate backbone.. AIM2 binds dsDNA in innate immune response No No No Yes 3a, decent circumstantial evidence for its role as Jussi Taipale Arttu Jolma No $#ENSG00000163568#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IDA - PMID:16432157$#ENSG00000163568#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IDA - PMID:19158675 $#ENSP00000357112#ENSG00000163568#ENST00000368130#Other#HIN, PYRIN$#ENSP00000357111#ENSG00000163568#ENST00000368129#Other#HIN FALSE 1763 ENSG00000142208 AKT1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000719;IPR000961;IPR001849;IPR002290;IPR008271;IPR011009;IPR017441;IPR017892 207 AKT serine/threonine kinase 1 [Source:HGNC Symbol;Acc:HGNC:391] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Arttu Jolma Matt Weirauch No $#ENSG00000142208#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:19057511 $#ENSP00000270202#ENSG00000142208#ENST00000349310#Other#Kinase-like, PH, PH_11, Pkinase, Pkinase_C, Pkinas$#ENSP00000385326#ENSG00000142208#ENST00000402615#Other#Kinase-like, PH, PH_11, Pkinase, Pkinase_C, Pkinas$#ENSP00000384293#ENSG00000142208#ENST00000407796#Other#Kinase-like, PH, PH_11, Pkinase, Pkinase_C, Pkinas$#ENSP00000451828#ENSG00000142208#ENST00000554581#Other#Kinase-like, PH, PH_11, Pkinase, Pkinase_C, Pkinas$#ENSP00000451166#ENSG00000142208#ENST00000554848#Other#Kinase-like, PH, PH_11, Pkinase, Pkinase_C, Pkinas$#ENSP00000450688#ENSG00000142208#ENST00000555528#Other#Kinase-like, PH, PH_11, Pkinase, Pkinase_C, Pkinas$#ENSP00000450681#ENSG00000142208#ENST00000554192#Other#Pkinase, Pkinase_C, Pkinase_Tyr$#ENSP00000451470#ENSG00000142208#ENST00000555458#Other#Kinase-like, Pkinase, Pkinase_C, Pkinase_Tyr$#ENSP00000451824#ENSG00000142208#ENST00000555926#Other#PH FALSE 1764 ENSG00000171094 ALK Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Operates far upstream in the signaling cascade IPR000719;IPR000998;IPR001245;IPR002011;IPR002172;IPR008266;IPR011009;IPR013320;IPR017441;IPR020635 238 anaplastic lymphoma receptor tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:427] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Laura Campitelli Arttu Jolma No $#ENSG00000171094#GO:0051092#positive regulation of NF-kappaB transcription factor activity#TAS - PMID:19459784 $#ENSP00000373700#ENSG00000171094#ENST00000389048#Other#Gly_rich, MAM, Pkinase, Pkinase_Tyr$#ENSP00000414027#ENSG00000171094#ENST00000431873#Other#Pkinase, Pkinase_Tyr$#ENSP00000387488#ENSG00000171094#ENST00000453137#Other#Pkinase_Tyr$#ENSP00000482733#ENSG00000171094#ENST00000618119#Other#Gly_rich, MAM, Pkinase, Pkinase_Tyr FALSE 1765 ENSG00000189046 ALKBH2 Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None Dioxygenase that repairs alkylated DNA and RNA containing 1-methyladenine and 3-methylcytosine by oxidative demethylation. Binds DNA in the crystal structure (PDB: 3BTX) None None alkB homolog 2, alpha-ketoglutarate dependent dioxygenase 3BTX not tested not tested None Dioxygenase that repairs alkylated DNA and RNA containing 1-methyladenine and 3-methylcytosine by oxidative demethylation. Binds DNA in the crystal structure (PDB: 3BTX) No No No No New proteins added based on PDB entry Arttu Jolma Sam Lambert No None None FALSE 1766 ENSG00000104899 AMH Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None None 100423031 Muellerian-inhibiting factor None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Jussi Taipale Laura Campitelli No $#ENSG00000104899#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IEA - GO_REF:0000019 $##ENSG00000104899##Other# FALSE 1767 ENSG00000176248 ANAPC2 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Scaffolding protein that associates with ubiquitin ligase complexes IPR001373;IPR014786;IPR016158; 29882 anaphase promoting complex subunit 2 [Source:HGNC Symbol;Acc:HGNC:19989] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Arttu Jolma Pratyush Das No None $#ENSP00000314004#ENSG00000176248#ENST00000323927#Other#ANAPC2, Cullin FALSE 1768 ENSG00000148513 ANKRD30A Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif Has a putative AT-hook GO citation (PMID: 11280766) has no evidence of DNA-binding activity and was based on homology IPR002110;IPR020683 91074 ankyrin repeat domain 30A [Source:HGNC Symbol;Acc:HGNC:17234] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Sam Lambert Arttu Jolma No $#ENSG00000148513#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:11280766 $#ENSP00000477963#ENSG00000148513#ENST00000611781#Other#Ank, Ank_2, Ank_3, Ank_4, Ank_5, CCDC144C$#ENSP00000354432#ENSG00000148513#ENST00000361713#Other#Ank, Ank_2, Ank_3, Ank_4, Ank_5, CCDC144C$#ENSP00000363792#ENSG00000148513#ENST00000374660#Other#Ank, Ank_2, Ank_3, Ank_4, Ank_5, CCDC144C$#ENSP00000473551#ENSG00000148513#ENST00000602533#Other#Ank, Ank_2, Ank_3, Ank_4, Ank_5, CCDC144C FALSE 1769 ENSG00000138772 ANXA3 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Protein operates far upstream on the signaling cascade. IPR001464;IPR002390;IPR018252;IPR018502 306 annexin A3 [Source:HGNC Symbol;Acc:HGNC:541] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Matt Weirauch Arttu Jolma No $#ENSG00000138772#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:16236264 $#ENSP00000264908#ENSG00000138772#ENST00000264908#Other#Annexin$#ENSP00000422281#ENSG00000138772#ENST00000508214#Other#Annexin$#ENSP00000426591#ENSG00000138772#ENST00000512542#Other#Annexin$#ENSP00000421512#ENSG00000138772#ENST00000514171#Other#Annexin FALSE 1770 ENSG00000196975 ANXA4 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR001464;IPR002391;IPR002392;IPR018252;IPR018502 307 annexin A4 [Source:HGNC Symbol;Acc:HGNC:542] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Jussi Taipale Laura Campitelli No $#ENSG00000196975#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IDA - PMID:20237821 $#ENSP00000377833#ENSG00000196975#ENST00000394295#Other#Annexin, Myb_DNA-bind_7$#ENSP00000386756#ENSG00000196975#ENST00000409920#Other#Annexin FALSE 1771 ENSG00000242802 AP5Z1 Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None May have helicase activity and play a role in DNA repair (PMID: 20613862) IPR028222; 9907 adaptor related protein complex 5 zeta 1 subunit [Source:HGNC Symbol;Acc:HGNC:22197] None not tested not tested None None No No No No 1a2, Orthologous HQ evidence Pratyush Das Jussi Taipale No None $#ENSP00000297562#ENSG00000242802#ENST00000348624#Other#SPG48 FALSE 1772 ENSG00000113108 APBB3 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR001202;IPR006020 102465499 amyloid beta precursor protein binding family B member 3 [Source:HGNC Symbol;Acc:HGNC:20708] None not tested not tested None None No No TF Gene_Transcription Factor Binding: tf co-factor binding_Co-activation; Other_PMIDS:10199399;15180993 No 5a, one of the source datasets predicts is as a TF Laura Campitelli Yimeng Yin No None $##ENSG00000113108##Other# FALSE 1773 ENSG00000100823 APEX1 Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None The structure (PDB:1DEW) is with abasic DNA - the protein is a base excision repair enzyme that cleaves off abasic bases IPR004808;IPR005135;IPR020847;IPR020848 328 apurinic/apyrimidinic endodeoxyribonuclease 1 [Source:HGNC Symbol;Acc:HGNC:587] 1DEW not tested not tested None The structure is with abasic DNA, the protein is a base excision repair enzyme that cleaves off abasic bases No No TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_Other_PMIDS:1380454;15084519;15674341 No 3a, decent circumstantial evidence for its role as Tim Hughes Arttu Jolma No None $##ENSG00000100823##Other# FALSE 1774 ENSG00000262156 APOBEC3A Unknown No ssDNA/RNA binding Not a DNA binding protein No motif None Binds ssDNA (PDB: 5KEG) None None apolipoprotein B mRNA editing enzyme catalytic subunit 3A 5KEG not tested not tested None Binds ssDNA (PDB: 5KEG) No No No No New proteins added based on PDB entry Arttu Jolma Sam Lambert No None None FALSE 1775 ENSG00000179750 APOBEC3B Unknown No ssDNA/RNA binding Not a DNA binding protein No motif None Binds ssDNA (PDB: 5TD5) None None apolipoprotein B mRNA editing enzyme catalytic subunit 3B 5TD5 not tested not tested None Binds ssDNA (PDB: 5TD5) No No No No New proteins added based on PDB entry Arttu Jolma Sam Lambert No None None FALSE 1776 ENSG00000239713 APOBEC3G Unknown No ssDNA/RNA binding Not a DNA binding protein No motif None Restriction factor of HIV-1 that binds ssDNA (PDB: 5K83) None None apolipoprotein B mRNA editing enzyme catalytic subunit 3G 5K83 not tested not tested None Restriction factor of HIV-1 that binds ssDNA (PDB: 5K83) No No No No New proteins added based on PDB entry Arttu Jolma Sam Lambert No None None FALSE 1777 ENSG00000137074 APTX Unknown No ssDNA/RNA binding Not a DNA binding protein No motif None Binds and fixes DNA-RNA hybrids/ APTX efficiently repairs adenylated RNA-DNA and acts in the RNA-DNA damage response (PMID: 24362567) IPR000253;IPR007087;IPR008984;IPR011146;IPR019808; 54840 aprataxin [Source:HGNC Symbol;Acc:HGNC:15984] 4NDF Full not tested None Binds and fixes DNA-RNA hybrids APTX efficiently repairs adenylated RNA-DNA, and acting in an RNA-DNA damage response (RDDR) pmid: 24362567 x No No No 3a, decent circumstantial evidence for its role as Yimeng Yin Arttu Jolma No None $#ENSP00000311547#ENSG00000137074#ENST00000309615#Other#DcpS_C, HIT, zf-C2HE$#ENSP00000369145#ENSG00000137074#ENST00000379817#Other#DcpS_C, FHA, HIT, zf-C2HE$#ENSP00000369147#ENSG00000137074#ENST00000379819#Other#DcpS_C, FHA, HIT, zf-C2HE$#ENSP00000380357#ENSG00000137074#ENST00000397172#Other#DcpS_C, FHA, HIT, zf-C2HE$#ENSP00000400806#ENSG00000137074#ENST00000436040#Other#DcpS_C, FHA, HIT, zf-C2HE$#ENSP00000419846#ENSG00000137074#ENST00000463596#Other#DcpS_C, FHA, HIT, zf-C2HE$#ENSP00000420263#ENSG00000137074#ENST00000468275#Other#DcpS_C, FHA, HIT, zf-C2HE$#ENSP00000419042#ENSG00000137074#ENST00000476858#Other#DcpS_C, HIT, zf-C2HE$#ENSP00000369153#ENSG00000137074#ENST00000379825#Other#DcpS_C, FHA, HIT$#ENSP00000419020#ENSG00000137074#ENST00000473221#Other#DcpS_C, HIT$#ENSP00000417649#ENSG00000137074#ENST00000477119#Other#DcpS_C, HIT FALSE 1778 ENSG00000160007 ARHGAP35 Unknown Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Binds DNA specifically based on EMSA and nuclease protection assay data (PMID: 1894621), despite lacking any clear DBDs. IPR000198;IPR001806;IPR002713;IPR008936;IPR027417; 2909 Rho GTPase activating protein 35 [Source:HGNC Symbol;Acc:HGNC:4591] None not tested not tested None None other No TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:1894621 Yes 4a, two or more datasets predict it as a TF Arttu Jolma Matt Weirauch No $#ENSG00000160007#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IDA - PMID:1894621 $#ENSP00000385720#ENSG00000160007#ENST00000404338#Other#FF, Ras, RhoGAP, RhoGAP-FF1$#ENSP00000483730#ENSG00000160007#ENST00000614079#Other#FF, Ras, RhoGAP, RhoGAP-FF1$#ENSP00000479487#ENSG00000160007#ENST00000615647#Other#FF, Ras, RhoGAP-FF1 FALSE 1779 ENSG00000116584 ARHGEF2 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000219;IPR001849;IPR002219 9181 Rho/Rac guanine nucleotide exchange factor 2 [Source:HGNC Symbol;Acc:HGNC:682] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Yimeng Yin Jussi Taipale No $#ENSG00000116584#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IDA - PMID:19043560, PMID:21887730 $#ENSP00000314787#ENSG00000116584#ENST00000313667#Other#C1_1, C1_2, PH, Prok-RING_1, RhoGEF$#ENSP00000315325#ENSG00000116584#ENST00000313695#Other#C1_1, C1_2, PH, Prok-RING_1, RhoGEF$#ENSP00000354837#ENSG00000116584#ENST00000361247#Other#C1_1, C1_2, PH, Prok-RING_1, RhoGEF$#ENSP00000476699#ENSG00000116584#ENST00000609707#Other#C1_1, C1_2, Prok-RING_1, zinc_ribbon_9$#ENSP00000476518#ENSG00000116584#ENST00000423422#Other#$#ENSP00000476689#ENSG00000116584#ENST00000470541#Other#$#ENSP00000476724#ENSG00000116584#ENST00000497907#Other#C1_1, C1_2, Prok-RING_1, zinc_ribbon_9 FALSE 1780 ENSG00000050327 ARHGEF5 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None GO annotation provides no evidence of DNA-binding activity (PMID: 15601624) IPR000219;IPR001331;IPR001452;IPR001849;IPR029212 102725117 Rho guanine nucleotide exchange factor 5 [Source:HGNC Symbol;Acc:HGNC:13209] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Sam Lambert Jussi Taipale No $#ENSG00000050327#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:15601624 $#ENSP00000056217#ENSG00000050327#ENST00000056217#Other#ARHGEF5_35, PH, RhoGEF, SH3_1, SH3_2, SH3_9$#ENSP00000418227#ENSG00000050327#ENST00000471847#Other#PH, RhoGEF, SH3_1, SH3_2, SH3_9$#ENSP00000417979#ENSG00000050327#ENST00000498580#Other#ARHGEF5_35$#ENSP00000418745#ENSG00000050327#ENST00000474817#Other#RhoGEF, SH3_1, SH3_2, SH3_9 FALSE 1781 ENSG00000137486 ARRB1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None ChIP data available, but unclear if it can bind to DNA directly (PMID: 16325578) IPR000698;IPR011021;IPR011022;IPR014756;IPR017864 408 arrestin beta 1 [Source:HGNC Symbol;Acc:HGNC:711] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Yimeng Yin Matt Weirauch No $#ENSG00000137486#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IDA - PMID:16378096 $#ENSP00000353124#ENSG00000137486#ENST00000360025#Other#Arrestin_C, Arrestin_N$#ENSP00000409581#ENSG00000137486#ENST00000420843#Other#Arrestin_C, Arrestin_N$#ENSP00000436530#ENSG00000137486#ENST00000532447#Other#Arrestin_C, Arrestin_N$#ENSP00000433171#ENSG00000137486#ENST00000532525#Other#Arrestin_C, Arrestin_N FALSE 1782 ENSG00000141480 ARRB2 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000698;IPR011021;IPR011022;IPR014756;IPR017864 409 arrestin beta 2 [Source:HGNC Symbol;Acc:HGNC:712] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Yimeng Yin Pratyush Das No $#ENSG00000141480#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IDA - PMID:15125834, PMID:16378096 $#ENSP00000269260#ENSG00000141480#ENST00000269260#Other#Arrestin_C, Arrestin_N$#ENSP00000466344#ENSG00000141480#ENST00000574954#Other#Arrestin_C$#ENSP00000341895#ENSG00000141480#ENST00000346341#Other#Arrestin_C, Arrestin_N$#ENSP00000370898#ENSG00000141480#ENST00000381488#Other#Arrestin_C, Arrestin_N$#ENSP00000403701#ENSG00000141480#ENST00000412477#Other#Arrestin_C, Arrestin_N$#ENSP00000465877#ENSG00000141480#ENST00000571428#Other#Arrestin_C FALSE 1783 ENSG00000138303 ASCC1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Protein is a coactivator that is reported to bind to SRF, NFKB1, and JUN (PMID: 12077347) IPR004087;IPR004088;IPR009097;IPR009210;IPR019510 51008 activating signal cointegrator 1 complex subunit 1 [Source:HGNC Symbol;Acc:HGNC:24268] None not tested not tested None None No No TF Gene_Transcription Factor Binding: tf co-factor binding_Co-activation_PMIDS:10454579 No 5a, one of the source datasets predicts is as a TF Arttu Jolma Sam Lambert No None $##ENSG00000138303##Other# FALSE 1784 ENSG00000171681 ATF7IP Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Murine homolog involved in H4K9 trimethylation by SETDB1 (PMID: 14536086) IPR003961 55729 activating transcription factor 7 interacting protein [Source:HGNC Symbol;Acc:HGNC:20092] None not tested not tested None None No No TF Gene_Transcription Factor Binding: tf co-factor binding_Co-activation; TF PPI_PMIDS:10777215;14536086 No 5a, one of the source datasets predicts is as a TF Laura Campitelli Jussi Taipale No None $##ENSG00000171681##Other# FALSE 1785 ENSG00000149311 ATM Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Kinase protein that binds to and activates certain TFs IPR000403;IPR003151;IPR003152;IPR011009;IPR014009;IPR016024;IPR018936;IPR021668 472 ataxia telangiectasia mutated homolog, ATM serine/threonine kinase [Source:HGNC Symbol;Acc:HGNC:795] None not tested not tested None None No No TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_Co-activation; DNA Binding_PMIDS:12496286;16461339;16644862 No 5a, one of the source datasets predicts is as a TF Jussi Taipale Arttu Jolma No None $##ENSG00000149311##Other# FALSE 1786 ENSG00000175054 ATR Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None None IPR000403;IPR003151;IPR003152;IPR011009;IPR012993;IPR014009;IPR016024;IPR018936;IPR021133 545 ATR serine/threonine kinase [Source:HGNC Symbol;Acc:HGNC:882] None not tested not tested None None No No TF Gene Candidate_Transcription Regulatory Activity: heterochromatin interaction/binding; Transcription Factor Binding: tf co-factor binding; Single stranded RNA/DNA binding_Other_PMIDS:10545197;12011 No 5a, one of the source datasets predicts is as a TF Sam Lambert Pratyush Das No None $##ENSG00000175054##Other# FALSE 1787 ENSG00000085224 ATRX Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None ATRX does not contain any canonical sequence-specific DBDs but it does contain a non-specific DNA binding helicase that allows it to bind repeat sequences (PMID:21029860) and telomeres (PMID:20651253). ATRX is involved in multiple processes (transcription, replication), and is associated with multiple complexes (Swi/Snf, histone chaperones, and repressive complexes including TRIM 28 (PMID:27029610)), and as such does affect transcription. Given the lack of sequence-specific binding it is unlikel None None None None not tested not tested None None No No No No Protein added after initial stage, no initial assesment Arttu Jolma Sam Lambert No None None FALSE 1788 ENSG00000163635 ATXN7 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None ATXN7 SCA7 domain facilitates interactions with histone dimers (PMID: 20634802) IPR013243; 6314 ataxin 7 [Source:HGNC Symbol;Acc:HGNC:10560] None not tested not tested None None c No No No 5a, one of the source datasets predicts is as a TF Sam Lambert Yimeng Yin No None $#ENSP00000295900#ENSG00000163635#ENST00000295900#Other#SCA7$#ENSP00000418203#ENSG00000163635#ENST00000474513#Other#$#ENSP00000428277#ENSG00000163635#ENST00000484332#Other#SCA7$#ENSP00000439585#ENSG00000163635#ENST00000538065#Other#SCA7$#ENSP00000428067#ENSG00000163635#ENST00000522345#Other# FALSE 1789 ENSG00000107262 BAG1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Antiapoptotic BCL-protein IPR000626;IPR003103;IPR017093;IPR029071 573 Bcl2-associated athanogene 1 None not tested not tested None None No No TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:9642262 No 5a, one of the source datasets predicts is as a TF Jussi Taipale Arttu Jolma No None $##ENSG00000107262##Other# FALSE 1790 ENSG00000175334 BANF1 Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None Binds DNA in the crystal structure, contacting only the backbone from the side of the minor groove (PDB: 2BZF) None None barrier to autointegration factor 1 2BZF not tested not tested None Binds DNA in the crystal structure, contacting only the backbone from the side of the minor groove (PDB: 2BZF) No No No No New proteins added based on PDB entry Arttu Jolma Sam Lambert No None None FALSE 1791 ENSG00000172530 BANP Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif Only known motifs are from Transfac or HocoMoco - origin is uncertain BANP has no DBD and is known to bind other TFs; likely that the Transfac motif is from one of its binding partners IPR018379 54971 BTG3 associated nuclear protein [Source:HGNC Symbol;Acc:HGNC:13450] None not tested not tested None None No Yes No No 2a1, Lower confidence direct evidence Arttu Jolma Sam Lambert No None $#ENSP00000347125#ENSG00000172530#ENST00000355022#Other#BEN, DUF1845$#ENSP00000432508#ENSG00000172530#ENST00000479780#Other#BEN, DUF1845$#ENSP00000444352#ENSG00000172530#ENST00000538234#Other#BEN, DUF1845$#ENSP00000376902#ENSG00000172530#ENST00000393207#Other#BEN$#ENSP00000376903#ENSG00000172530#ENST00000393208#Other#BEN, DUF1845$#ENSP00000487304#ENSG00000172530#ENST00000626016#Other#BEN, DUF1845$#ENSP00000401454#ENSG00000172530#ENST00000436274#Other# FALSE 1792 ENSG00000142867 BCL10 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Apoptosis associated protein that operates upstream on a cascade that includes NFKB IPR001315;IPR011029 8915 B-cell CLL/lymphoma 10 [Source:HGNC Symbol;Acc:HGNC:989] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Matt Weirauch Arttu Jolma No $#ENSG00000142867#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IDA - PMID:10400625, PMID:14695475 $#ENSP00000359612#ENSG00000142867#ENST00000370580#Other#CARD$#ENSP00000480561#ENSG00000142867#ENST00000620248#Other#CARD, CARD_2 FALSE 1793 ENSG00000069399 BCL3 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif Only known motifs are from Transfac or HocoMoco - origin is uncertain No DBD - instead, this is a known cofactor of NF-kappaB. The Transfac motif is the NFKB1 motif. GO cites only electronic annotation and needs to be fixed. IPR002110;IPR020683 102465879 B-cell CLL/lymphoma 3 [Source:HGNC Symbol;Acc:HGNC:998] None not tested not tested None None No Yes TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:1501714 No 2a1, Lower confidence direct evidence Arttu Jolma Tim Hughes Yes $#ENSG00000069399#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019 $#ENSP00000164227#ENSG00000069399#ENST00000164227#Other#Ank, Ank_2, Ank_3, Ank_4, Ank_5$#ENSP00000393731#ENSG00000069399#ENST00000444487#Other#Ank, Ank_2, Ank_3, Ank_4, Ank_5 FALSE 1794 ENSG00000029363 BCLAF1 Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain No DBD. Only weak evidence is available for indirect binding (PMID: 10330179). Suspect motif - it is a clear ETS-site. (PMID: 10330179) shows that the protein binds DNA in filter binding assay, but not that it is sequence specific. IPR018545;IPR029199 9774 BCL2 associated transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:16863] None not tested not tested None None other Yes No No 2a1, Lower confidence direct evidence Pratyush Das Arttu Jolma No None $#ENSP00000434826#ENSG00000029363#ENST00000527759#Other#THRAP3_BCLAF1$#ENSP00000436501#ENSG00000029363#ENST00000530767#Other#THRAP3_BCLAF1$#ENSP00000435210#ENSG00000029363#ENST00000531224#Other#THRAP3_BCLAF1$#ENSP00000437018#ENSG00000029363#ENST00000534762#Other#Btz FALSE 1795 ENSG00000183337 BCOR Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Transcriptional co-repressor that associates with BCL6 (PMID: 10898795) IPR002110;IPR020683 54880 BCL6 corepressor [Source:HGNC Symbol;Acc:HGNC:20893] None not tested not tested None None No No TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_Co-activation; TF PPI_PMIDS:10898795;10898795 No 5a, one of the source datasets predicts is as a TF Sam Lambert Arttu Jolma No None $##ENSG00000183337##Other# FALSE 1796 ENSG00000145734 BDP1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR001005;IPR009057 55814 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB [Source:HGNC Sy None Full not tested None None x No TF Gene_Basal Transcription Factor_TF PPI_PMIDS:11971960;12930823;14527415;15469824 No 4a, two or more datasets predict it as a TF Pratyush Das Jussi Taipale No None $#ENSP00000351575#ENSG00000145734#ENST00000358731#Other#Myb_DNA-bind_7$#ENSP00000370050#ENSG00000145734#ENST00000380675#Other#Myb_DNA-bind_7 FALSE 1797 ENSG00000133169 BEX1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Likely a cofactor- (PMID: 16314316) shows results for related BEX2 IPR007623;IPR021156 55859 brain expressed X-linked 1 [Source:HGNC Symbol;Acc:HGNC:1036] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Arttu Jolma Matt Weirauch No $#ENSG00000133169#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:16314316 $#ENSP00000361813#ENSG00000133169#ENST00000372728#Other#BEX FALSE 1798 ENSG00000136717 BIN1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR001452;IPR003005;IPR003023;IPR004148 274 bridging integrator 1 [Source:HGNC Symbol;Acc:HGNC:1052] None not tested not tested None None No No Indeterminate - There is no evidence for or against this genes role as a TF__Co-activation_PMIDS:15992821 No 5a, one of the source datasets predicts is as a TF Tim Hughes Jussi Taipale No None $##ENSG00000136717##Other# FALSE 1799 ENSG00000197299 BLM Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None Helicase involved in DNA replication and repair (PDB: 4CGZ) None None Bloom syndrome RecQ like helicase 4CGZ not tested not tested None Helicase involved in DNA replication and repair (PDB: 4CGZ) No No No No New proteins added based on PDB entry Arttu Jolma Sam Lambert No None None FALSE 1800 ENSG00000117475 BLZF1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None This is a golgi protein with no evidence for DNA binding. IPR013183 8548 basic leucine zipper nuclear factor 1 [Source:HGNC Symbol;Acc:HGNC:1065] None not tested not tested None None No No TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_Other_PMIDS:9129147;10602419 Yes 4a, two or more datasets predict it as a TF Jussi Taipale Matt Weirauch No $#ENSG00000117475#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:9129147 $#ENSP00000327541#ENSG00000117475#ENST00000329281#Other#DASH_Hsk3$#ENSP00000356781#ENSG00000117475#ENST00000367807#Other#$#ENSP00000356782#ENSG00000117475#ENST00000367808#Other#DASH_Hsk3$#ENSP00000414668#ENSG00000117475#ENST00000420531#Other#$#ENSP00000404408#ENSG00000117475#ENST00000426663#Other#DASH_Hsk3 FALSE 1801 ENSG00000168283 BMI1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None BMI1 binds to nucleosomes as part of the PRC1 complex but does not contact the DNA directly (PDB: 4R8P) IPR001841;IPR017907;IPR018957; 648 BMI1 proto-oncogene, polycomb ring finger [Source:HGNC Symbol;Acc:HGNC:1066] 4R8P DBD not tested None Does not contact DNA in the structure, but contacts core-nucleosomes and RNF2 b No TF Gene_Transcription Regulatory Activity: heterochromatin interaction/binding_DNA Binding_PMIDS:1823128;10500182;15386022 No 3a, decent circumstantial evidence for its role as Sam Lambert Laura Campitelli No None $#ENSP00000365851#ENSG00000168283#ENST00000376663#Other#Prok-RING_4, RAWUL, zf-C3HC4, zf-C3HC4_2, zf-C3HC4$#ENSP00000390768#ENSG00000168283#ENST00000443519#Other#Prok-RING_4, RAWUL, zf-C3HC4, zf-C3HC4_2, zf-C3HC4$#ENSP00000399220#ENSG00000168283#ENST00000416820#Other#Prok-RING_4, zf-C3HC4, zf-C3HC4_2, zf-C3HC4_3, zf-$#ENSP00000397912#ENSG00000168283#ENST00000442508#Other#Prok-RING_4, zf-C3HC4, zf-C3HC4_2, zf-C3HC4_3, zf- FALSE 1802 ENSG00000125845 BMP2 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR001111;IPR001839;IPR002405;IPR017948;IPR029034; 650 bone morphogenetic protein 2 [Source:HGNC Symbol;Acc:HGNC:1069] None not tested not tested None None other No No No 5a, one of the source datasets predicts is as a TF Sam Lambert Matt Weirauch No None $#ENSP00000368104#ENSG00000125845#ENST00000378827#Other#TGF_beta, TGFb_propeptide FALSE 1803 ENSG00000125378 BMP4 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Likely a cofactor. IPR001111;IPR001839;IPR017948;IPR029034 652 bone morphogenetic protein 4 [Source:HGNC Symbol;Acc:HGNC:1071] None not tested not tested None None No No Indeterminate - There is no evidence for or against this genes role as a TF__TF PPI_PMIDS:12538588 No 5a, one of the source datasets predicts is as a TF Laura Campitelli Matt Weirauch No None $##ENSG00000125378##Other# FALSE 1804 ENSG00000101144 BMP7 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR001111;IPR001839;IPR002405;IPR017948;IPR029034 655 bone morphogenetic protein 7 [Source:HGNC Symbol;Acc:HGNC:1074] None not tested not tested None None No No Indeterminate - There is no evidence for or against this genes role as a TF__TF PPI_PMIDS:9369451 Yes 4a, two or more datasets predict it as a TF Jussi Taipale Yimeng Yin No $#ENSG00000101144#GO:0032088#negative regulation of NF-kappaB transcription factor activity#ISS - GO_REF:0000024 $#ENSP00000379204#ENSG00000101144#ENST00000395863#Other#TGF_beta, TGFb_propeptide$#ENSP00000398687#ENSG00000101144#ENST00000450594#Other#TGF_beta, TGFb_propeptide$#ENSP00000379205#ENSG00000101144#ENST00000395864#Other#TGF_beta, TGFb_propeptide$#ENSP00000390814#ENSG00000101144#ENST00000433911#Other#TGF_beta, TGFb_propeptide FALSE 1805 ENSG00000107779 BMPR1A Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None None 657 Bone morphogenetic protein receptor type-1A None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Sam Lambert Laura Campitelli No $#ENSG00000107779#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IEA - GO_REF:0000019 $##ENSG00000107779##Other# FALSE 1806 ENSG00000038219 BOD1L1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif Has a putative AT-hook None IPR026955; 259282 biorientation of chromosomes in cell division 1 like 1 [Source:HGNC Symbol;Acc:HGNC:31792] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Arttu Jolma Jussi Taipale No None $#ENSP00000040738#ENSG00000038219#ENST00000040738#Other#COMPASS-Shg1$#ENSP00000425492#ENSG00000038219#ENST00000507943#Other# FALSE 1807 ENSG00000178096 BOLA1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR002634; 51027 bolA family member 1 [Source:HGNC Symbol;Acc:HGNC:24263] None Full not tested None None c No No No 5a, one of the source datasets predicts is as a TF Pratyush Das Yimeng Yin No None $#ENSP00000358148#ENSG00000178096#ENST00000369152#Other#BolA$#ENSP00000358146#ENSG00000178096#ENST00000369150#Other#BolA$#ENSP00000358149#ENSG00000178096#ENST00000369153#Other#BolA FALSE 1808 ENSG00000183336 BOLA2 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR002634; 107984053 BolA family member 2 [Source:HGNC Symbol;Acc:HGNC:29488] None not tested not tested None None c No No No 5a, one of the source datasets predicts is as a TF Yimeng Yin Sam Lambert No None $#ENSP00000331127#ENSG00000183336#ENST00000330978#Other#BolA FALSE 1809 ENSG00000169627 BOLA2B Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR002634; 107984053 BolA family member 2B [Source:HGNC Symbol;Acc:HGNC:32479] None not tested not tested None None c No No No 5a, one of the source datasets predicts is as a TF Sam Lambert Matt Weirauch No None $#ENSP00000306752#ENSG00000169627#ENST00000305321#Other#BolA$#ENSP00000457995#ENSG00000169627#ENST00000567436#Other#BolA$#ENSP00000455468#ENSG00000169627#ENST00000569282#Other# FALSE 1810 ENSG00000163170 BOLA3 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None E. Coli homologue of the BOLA binds DNA; however there is no evidence in the mammalian proteins IPR002634; 388962 bolA family member 3 [Source:HGNC Symbol;Acc:HGNC:24415] None not tested not tested None None c No No No 5a, one of the source datasets predicts is as a TF Pratyush Das Arttu Jolma No None $#ENSP00000295326#ENSG00000163170#ENST00000295326#Other#$#ENSP00000331369#ENSG00000163170#ENST00000327428#Other#BolA FALSE 1811 ENSG00000162813 BPNT1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000760;IPR020550;IPR020583; 10380 3(2), 5-bisphosphate nucleotidase 1 [Source:HGNC Symbol;Acc:HGNC:1096] None Full not tested None None x No No No 5a, one of the source datasets predicts is as a TF Laura Campitelli Yimeng Yin No None $#ENSP00000318852#ENSG00000162813#ENST00000322067#Other#Inositol_P$#ENSP00000410348#ENSG00000162813#ENST00000414869#Other#Inositol_P$#ENSP00000444398#ENSG00000162813#ENST00000544404#Other#Inositol_P$#ENSP00000446953#ENSG00000162813#ENST00000463953#Other#Inositol_P$#ENSP00000449883#ENSG00000162813#ENST00000498237#Other#Inositol_P$#ENSP00000446850#ENSG00000162813#ENST00000498791#Other#Inositol_P FALSE 1812 ENSG00000171634 BPTF Unknown Yes Known motif Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain; Has a putative AT-hook (PMID: 10575013) obtained a motif by SELEX and showed that mutating the sequence diminished binding in vitro. Unusual for a PHD/Ring finger, but its there in the literature. IPR001487;IPR001965;IPR004022;IPR011011;IPR018359;IPR018500;IPR018501;IPR019786;IPR019787;IPR028942 2186 bromodomain PHD finger transcription factor [Source:HGNC Symbol;Acc:HGNC:3581] None not tested not tested None None No Yes TF Gene_Transcription Factor Binding: tf co-factor binding; DNA-Binding: sequence-specific_DNA Binding_PMIDS:10575013;10727212 No 2a1, Lower confidence direct evidence Yimeng Yin Matt Weirauch No None $#ENSP00000307208#ENSG00000171634#ENST00000306378#Other#Bromodomain, DDT, PHD, WHIM1, WSD$#ENSP00000343837#ENSG00000171634#ENST00000342579#Other#Bromodomain, PHD$#ENSP00000388405#ENSG00000171634#ENST00000424123#Other#Bromodomain, DDT, PHD, WHIM1, WSD$#ENSP00000462535#ENSG00000171634#ENST00000580465#Other#$#ENSP00000463845#ENSG00000171634#ENST00000581258#Other#Bromodomain, DUF4428, PHD$#ENSP00000463736#ENSG00000171634#ENST00000583990#Other#Bromodomain$#ENSP00000443949#ENSG00000171634#ENST00000544491#Other#$#ENSP00000462703#ENSG00000171634#ENST00000577837#Other#Bromodomain FALSE 1813 ENSG00000012048 BRCA1 Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein In vivo/Misc source None BRCA1 likely binds to DNA without DNA sequence specificity (PMID: 11353843) IPR001357;IPR001841;IPR011364;IPR017907;IPR018957;IPR025994 672 BRCA1, DNA repair associated [Source:HGNC Symbol;Acc:HGNC:1100] None not tested not tested None Jaspar SELEX model has very small information content, looking like an selection artefact b Yes No No 2a1, Lower confidence direct evidence Pratyush Das Yimeng Yin No None $#ENSP00000326002#ENSG00000012048#ENST00000354071#Other#BRCT_assoc, Prok-RING_4, zf-ANAPC11, zf-C3HC4, zf-$#ENSP00000350283#ENSG00000012048#ENST00000357654#Other#BRCT, BRCT_2, BRCT_assoc, Prok-RING_4, zf-ANAPC11,$#ENSP00000417148#ENSG00000012048#ENST00000468300#Other#BRCT, Prok-RING_4, zf-ANAPC11, zf-C3HC4, zf-C3HC4_$#ENSP00000419274#ENSG00000012048#ENST00000470026#Other#BRCT_assoc, Prok-RING_4, zf-ANAPC11, zf-C3HC4, zf-$#ENSP00000418960#ENSG00000012048#ENST00000471181#Other#BRCT, BRCT_2, BRCT_assoc, Prok-RING_4, zf-ANAPC11,$#ENSP00000419988#ENSG00000012048#ENST00000477152#Other#BRCT_assoc, zf-C3HC4, zf-C3HC4_2, zf-C3HC4_4, zf-N$#ENSP00000420412#ENSG00000012048#ENST00000478531#Other#BRCT, Prok-RING_4, zf-ANAPC11, zf-C3HC4, zf-C3HC4_$#ENSP00000419103#ENSG00000012048#ENST00000494123#Other#BRCT_assoc, Prok-RING_4, zf-ANAPC11, zf-C3HC4, zf-$#ENSP00000418986#ENSG00000012048#ENST00000497488#Other#BRCT_assoc$#ENSP00000465818#ENSG00000012048#ENST00000586385#Other#BRCT, BRCT_2$#ENSP00000467329#ENSG00000012048#ENST00000591534#Other#BRCT, BRCT_2$#ENSP00000465347#ENSG00000012048#ENST00000591849#Other#BRCT$#ENSP00000478114#ENSG00000012048#ENST00000618469#Other#$#ENSP00000417241#ENSG00000012048#ENST00000461574#Other#$#ENSP00000420201#ENSG00000012048#ENST00000473961#Other#BRCT_assoc$#ENSP00000418819#ENSG00000012048#ENST00000493919#Other#BRCT FALSE 1814 ENSG00000141867 BRD4 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Binds acetylated histones IPR001487;IPR018359;IPR027353 23476 bromodomain containing 4 [Source:HGNC Symbol;Acc:HGNC:13575] None not tested not tested None None No No TF Gene Candidate__Co-activation_PMIDS:16109376 No 5a, one of the source datasets predicts is as a TF Laura Campitelli Yimeng Yin No None $##ENSG00000141867##Other# FALSE 1815 ENSG00000166164 BRD7 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR001487;IPR021900 29117 bromodomain containing 7 [Source:HGNC Symbol;Acc:HGNC:14310] None not tested not tested None None No No TF Gene_Transcription Regulatory Activity: heterochromatin interaction/binding_Co-activation_PMIDS:12489984 No 5a, one of the source datasets predicts is as a TF Sam Lambert Jussi Taipale No None $##ENSG00000166164##Other# FALSE 1816 ENSG00000112983 BRD8 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif Has a putative AT-hook TF-coactivator IPR001487 10902 bromodomain containing 8 [Source:HGNC Symbol;Acc:HGNC:19874] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Matt Weirauch Arttu Jolma No $#ENSG00000112983#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:8611617$#ENSG00000112983#GO:0004887#thyroid hormone receptor activity#TAS - PMID:9368056 $#ENSP00000230901#ENSG00000112983#ENST00000230901#Other#Bromodomain$#ENSP00000254900#ENSG00000112983#ENST00000254900#Other#Bromodomain$#ENSP00000392646#ENSG00000112983#ENST00000427976#Other#Bromodomain FALSE 1817 ENSG00000028310 BRD9 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Evidence ony for interaction with histones (PMID: 22464331) IPR001487;IPR021900 65980 bromodomain containing 9 [Source:HGNC Symbol;Acc:HGNC:25818] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Laura Campitelli Sam Lambert No None $#ENSP00000419765#ENSG00000028310#ENST00000467963#Other#Bromodomain, DUF3512$#ENSP00000419845#ENSG00000028310#ENST00000483173#Other#Bromodomain, DUF3512$#ENSP00000420722#ENSG00000028310#ENST00000489093#Other#Bromodomain, DUF3512 FALSE 1818 ENSG00000185024 BRF1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif Only known motifs are from Transfac or HocoMoco - origin is uncertain GTF - Pol III - TRANSFAC has a motif but its likely not for this protein, but for the complex as a whole IPR000812;IPR011665;IPR013137;IPR013150;IPR013763 2972 BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit [Source:HGNC Symbol;Acc:HGNC 1NGM not tested not tested None In the structure the BRFIII does not contact DNA, (structure is for the yeast homolog) No Yes TF Gene_Basal Transcription Factor_Other_PMIDS:8943358;12198173;14976220;15538381 No 2a1, Lower confidence direct evidence Yimeng Yin Jussi Taipale No None $#ENSP00000369269#ENSG00000185024#ENST00000379937#Other#BRF1, Cyclin_N, RB_B, TFIIB, TF_Zn_Ribbon$#ENSP00000376340#ENSG00000185024#ENST00000392557#Other#BRF1, TFIIB$#ENSP00000448387#ENSG00000185024#ENST00000547530#Other#BRF1, Cyclin_N, RB_B, TFIIB, TF_Zn_Ribbon$#ENSP00000446707#ENSG00000185024#ENST00000548421#Other#Cyclin_N, RB_B, TFIIB, TF_Zn_Ribbon$#ENSP00000446901#ENSG00000185024#ENST00000551787#Other#TFIIB$#ENSP00000329029#ENSG00000185024#ENST00000327359#Other#BRF1, Cyclin_N, TFIIB$#ENSP00000388877#ENSG00000185024#ENST00000440513#Other#BRF1, Cyclin_N, TFIIB$#ENSP00000389859#ENSG00000185024#ENST00000446501#Other#BRF1$#ENSP00000448723#ENSG00000185024#ENST00000549655#Other#TFIIB$#ENSP00000450258#ENSG00000185024#ENST00000546417#Other#TFIIB$#ENSP00000449173#ENSG00000185024#ENST00000550208#Other#TFIIB$#ENSP00000447521#ENSG00000185024#ENST00000550375#Other# FALSE 1819 ENSG00000104221 BRF2 Unknown Yes Likely to be sequence specific TF Low specificity DNA-binding protein No motif None Makes backbone and sequence-specific interactions with DNA (PDB: 4ROC), but only involved in recognizing dinucleotides flanking the TATA box (PMID: 26638071). Redox sensing determines activation and repression of target genes None None BRF2, RNA polymerase III transcription initiation factor 50 kDa subunit 4ROC not tested not tested None Makes backbone and sequence-specific interactions with DNA (PDB: 4ROC), but only involved in recognizing dinucleotides flanking the TATA box (PMID: 26638071). Redox sensing determines activation and repression of target genes No No No No New proteins added based on PDB entry Arttu Jolma Sam Lambert No None None FALSE 1820 ENSG00000174744 BRMS1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None BRMS1 functions as a corepressor by promoting binding of HDAC1 to RelA/p65, where it deacetylates lysine K310 on RelA/p65, which suppresses RelA/p65 transcriptional activity (PMID: 17000776) IPR013907 25855 breast cancer metastasis suppressor 1 [Source:HGNC Symbol;Acc:HGNC:17262] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Jussi Taipale Arttu Jolma No $#ENSG00000174744#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IDA - PMID:17000776 $#ENSP00000353042#ENSG00000174744#ENST00000359957#Other#Sds3$#ENSP00000433740#ENSG00000174744#ENST00000530756#Other#Sds3$#ENSP00000431510#ENSG00000174744#ENST00000524699#Other#Sds3$#ENSP00000396052#ENSG00000174744#ENST00000425825#Other#Sds3 FALSE 1821 ENSG00000156983 BRPF1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif Has a putative AT-hook None IPR000313;IPR001487;IPR001965;IPR007087;IPR011011;IPR018359;IPR019542;IPR019786;IPR019787; 7862 bromodomain and PHD finger containing 1 [Source:HGNC Symbol;Acc:HGNC:14255] None Full not tested None None x No No No 5a, one of the source datasets predicts is as a TF Sam Lambert Matt Weirauch No None $#ENSP00000373340#ENSG00000156983#ENST00000383829#Other#Bromodomain, EPL1, PHD, PHD_2, PWWP, zf-HC5HC2H, z$#ENSP00000398863#ENSG00000156983#ENST00000424362#Other#Bromodomain, EPL1, PHD, PHD_2, PWWP, zf-HC5HC2H, z$#ENSP00000402485#ENSG00000156983#ENST00000433861#Other#Bromodomain, EPL1, PHD, PHD_2, PWWP, zf-HC5HC2H, z$#ENSP00000410210#ENSG00000156983#ENST00000457855#Other#Bromodomain, EPL1, PHD, PHD_2, PWWP, zf-HC5HC2H, z$#ENSP00000416728#ENSG00000156983#ENST00000420291#Other# FALSE 1822 ENSG00000095564 BTAF1 Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None Protein that uses ATP to dissociate TBP from the promoter IPR000330;IPR001650;IPR014001;IPR016024;IPR022707;IPR027417 9044 B-TFIID TATA-box binding protein associated factor 1 [Source:HGNC Symbol;Acc:HGNC:17307] None not tested not tested None None No No TF Gene_Basal Transcription Factor_TF PPI_PMIDS:11585931 Yes 4a, two or more datasets predict it as a TF Arttu Jolma Matt Weirauch No $#ENSG00000095564#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:9342322 $#ENSP00000265990#ENSG00000095564#ENST00000265990#Other#DUF3535, HEAT, HEAT_2, HEAT_EZ, Helicase_C, SNF2_N$#ENSP00000439924#ENSG00000095564#ENST00000544642#Other#DUF3535, HEAT, HEAT_2, HEAT_EZ, Helicase_C, SNF2_N FALSE 1823 ENSG00000189195 BTBD8 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Probably annotated as TF based on presence of a BTB domain; however, these domains are not known to bind DNA IPR000210;IPR011333;IPR013069 284697 BTB domain containing 8 [Source:HGNC Symbol;Acc:HGNC:21019];BTB/POZ domain-containing protein 8 None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Jussi Taipale Sam Lambert No $#ENSG00000189195#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000343686#ENSG00000189195#ENST00000342818#Other#BACK, BTB$#ENSP00000359404#ENSG00000189195#ENST00000370378#Other#BACK, DUF4596$#ENSP00000490161#ENSG00000189195#ENST00000636805#Other#BACK, BTB, DUF4596$#ENSP00000490913#ENSG00000189195#ENST00000637221#Other#DUF4596 FALSE 1824 ENSG00000159388 BTG2 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Transcriptional co-factor (PMID: 10617598) IPR002087; 7832 BTG family member 2 [Source:HGNC Symbol;Acc:HGNC:1131] None not tested not tested None None b No No No 5a, one of the source datasets predicts is as a TF Sam Lambert Pratyush Das No $#ENSG00000159388#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019 $#ENSP00000290551#ENSG00000159388#ENST00000290551#Other#BTG FALSE 1825 ENSG00000010671 BTK Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Involved in the regulation of ARID3A and NFAT in B lymphocyte development; has been thoroughly investigated, but there is no evidence to demonstrate DNA binding activity (see UniProt Q06187) IPR000719;IPR000980;IPR001245;IPR001452;IPR001562;IPR001849;IPR008266;IPR011009;IPR017441;IPR020635 695 Bruton tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:1133] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Yimeng Yin Laura Campitelli No $#ENSG00000010671#GO:0051092#positive regulation of NF-kappaB transcription factor activity#TAS - PMID:19290921 $#ENSP00000308176#ENSG00000010671#ENST00000308731#Other#BTK, Kinase-like, PH, Pkinase, Pkinase_Tyr, SH2, S$#ENSP00000483570#ENSG00000010671#ENST00000621635#Other#BTK, Kinase-like, PH, Pkinase, Pkinase_Tyr, SH2, S$#ENSP00000361971#ENSG00000010671#ENST00000372880#Other#BTK, PH, Pkinase, Pkinase_Tyr, SH2, SH3_1, SH3_2, $#ENSP00000479125#ENSG00000010671#ENST00000618050#Other#BTK, PH, Pkinase, Pkinase_Tyr, SH2, SH3_1, SH3_2, FALSE 1826 ENSG00000166167 BTRC Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR001680;IPR001810;IPR017986;IPR019775;IPR020472;IPR021977 8945 beta-transducin repeat containing E3 ubiquitin protein ligase [Source:HGNC Symbol;Acc:HGNC:1144] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Matt Weirauch Jussi Taipale No $#ENSG00000166167#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#TAS - PMID:11001584 $#ENSP00000359206#ENSG00000166167#ENST00000370187#Other#ANAPC4_WD40, Beta-TrCP_D, F-box, F-box-like, Nup16$#ENSP00000377088#ENSG00000166167#ENST00000393441#Other#ANAPC4_WD40, Beta-TrCP_D, F-box, F-box-like, Nup16$#ENSP00000385339#ENSG00000166167#ENST00000408038#Other#ANAPC4_WD40, Beta-TrCP_D, F-box, F-box-like, Nup16$#ENSP00000359202#ENSG00000166167#ENST00000370183#Other#Beta-TrCP_D FALSE 1827 ENSG00000106245 BUD31 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Included because GO says its DNA binding on the basis of (PMID: 7841202), a 1995 paper that only suggests DNA binding on the basis of the protein sequence. In fact, it is composed entirely of a G10 domain. IPR001748;IPR018230 8896 BUD31 homolog [Source:HGNC Symbol;Acc:HGNC:29629] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Tim Hughes Jussi Taipale No $#ENSG00000106245#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:7841202$#ENSG00000106245#GO:2000825#positive regulation of androgen receptor activity#IDA - PMID:25091737 $#ENSP00000222969#ENSG00000106245#ENST00000222969#Other#G10$#ENSP00000386023#ENSG00000106245#ENST00000403633#Other#G10$#ENSP00000408269#ENSG00000106245#ENST00000431419#Other#G10$#ENSP00000395269#ENSG00000106245#ENST00000456893#Other#G10 FALSE 1828 ENSG00000179008 C14orf39 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR031380 317761 chromosome 14 open reading frame 39 [Source:HGNC Symbol;Acc:HGNC:19849] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Yimeng Yin Laura Campitelli No $#ENSG00000179008#GO:0051090#regulation of sequence-specific DNA binding transcription factor activity#NAS - PMID:15703187 $#ENSP00000324920#ENSG00000179008#ENST00000321731#Other#S6OS1$#ENSP00000451441#ENSG00000179008#ENST00000556799#Other#DUF1664, S6OS1, polyprenyl_synt$#ENSP00000451665#ENSG00000179008#ENST00000555476#Other#S6OS1 FALSE 1829 ENSG00000197223 C1D Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None C1D has been shown to bind RNA (PMID: 17412707) and is associated with the exosome. C1D is also associated with DNA repair and has DNA-binding activitiy (PMID: 10362552) IPR007146 10438 C1D nuclear receptor corepressor [Source:HGNC Symbol;Acc:HGNC:29911] None not tested not tested None None No No TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_Co-activation; TF PPI_PMIDS:9405624 No 5a, one of the source datasets predicts is as a TF Sam Lambert Yimeng Yin No None $##ENSG00000197223##Other# FALSE 1830 ENSG00000088854 C20orf194 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None None 25943 chromosome 20 open reading frame 194 [Source:HGNC Symbol;Acc:HGNC:17721] None Full not tested None None c No No No 5a, one of the source datasets predicts is as a TF Yimeng Yin Sam Lambert No None $#ENSP00000252032#ENSG00000088854#ENST00000252032#Other#SIR2_2 FALSE 1831 ENSG00000174928 C3orf33 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Some effect on DNA-binding of AP-1 (PMID: 20680465), but does no data supporting a role for C3orf33 as a DNA-binding factor itself IPR016071 285315 chromosome 3 open reading frame 33 [Source:HGNC Symbol;Acc:HGNC:26434] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Sam Lambert Pratyush Das No $#ENSG00000174928#GO:0051090#regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:20680465 $#ENSP00000342512#ENSG00000174928#ENST00000340171#Other#$#ENSP00000445446#ENSG00000174928#ENST00000534941#Other# FALSE 1832 ENSG00000105298 CACTIN Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Protein operates on a signaling cascade far upstream of NFKB (PMID: 20829348) IPR018816;IPR019134 58509 cactin, spliceosome C complex subunit [Source:HGNC Symbol;Acc:HGNC:29938] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Jussi Taipale Arttu Jolma No $#ENSG00000105298#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IDA - PMID:20829348 $#ENSP00000221899#ENSG00000105298#ENST00000221899#Other#CactinC_cactus, Cactin_mid$#ENSP00000467149#ENSG00000105298#ENST00000592721#Other#CactinC_cactus$#ENSP00000415078#ENSG00000105298#ENST00000429344#Other#CactinC_cactus, Cactin_mid$#ENSP00000467788#ENSG00000105298#ENST00000588749#Other#Cactin_mid FALSE 1833 ENSG00000183049 CAMK1D Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Functions in signalling cascade that leads to phosphorylation and activation of CREB (PMID: 16324104) IPR000719;IPR002290;IPR008271;IPR011009;IPR017441 57118 calcium/calmodulin dependent protein kinase ID [Source:HGNC Symbol;Acc:HGNC:19341] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Arttu Jolma Yimeng Yin No $#ENSG00000183049#GO:0032793#positive regulation of CREB transcription factor activity#IDA - PMID:16324104 $#ENSP00000368122#ENSG00000183049#ENST00000378845#Other#APH, Kdo, Kinase-like, Pkinase, Pkinase_Tyr, RIO1$#ENSP00000478874#ENSG00000183049#ENST00000619168#Other#APH, Kdo, Kinase-like, Pkinase, Pkinase_Tyr, RIO1$#ENSP00000478861#ENSG00000183049#ENST00000615792#Other#Kdo, Kinase-like, Pkinase, Pkinase_Tyr FALSE 1834 ENSG00000070808 CAMK2A Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000719;IPR002290;IPR008271;IPR011009;IPR013543;IPR017441 815 calcium/calmodulin dependent protein kinase II alpha [Source:HGNC Symbol;Acc:HGNC:1460] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Yimeng Yin Matt Weirauch No $#ENSG00000070808#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IMP - PMID:17052756 $#ENSP00000261793#ENSG00000070808#ENST00000348628#Other#APH, CaMKII_AD, DUF4440, Kdo, Pkinase, Pkinase_Tyr$#ENSP00000381412#ENSG00000070808#ENST00000398376#Other#APH, CaMKII_AD, DUF4440, Kdo, Pkinase, Pkinase_Tyr$#ENSP00000426607#ENSG00000070808#ENST00000510347#Other#Pkinase, Pkinase_Tyr$#ENSP00000427580#ENSG00000070808#ENST00000515758#Other#Pkinase FALSE 1835 ENSG00000103326 CAPN15 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Basically an unknown protein - a likely protease that contains also znfRANBP-domains, so it could be a RNA-binding protein IPR000169;IPR001300;IPR001876;IPR022684 6650 calpain 15 [Source:HGNC Symbol;Acc:HGNC:11182] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Arttu Jolma Yimeng Yin No $#ENSG00000103326#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:9722942 $#ENSP00000219611#ENSG00000103326#ENST00000219611#Other#DZR, Peptidase_C2, zf-RanBP$#ENSP00000456017#ENSG00000103326#ENST00000562370#Other#DZR, zf-RanBP$#ENSP00000457030#ENSG00000103326#ENST00000568988#Other#$#ENSP00000490480#ENSG00000103326#ENST00000637507#Other#DZR, zf-RanBP FALSE 1836 ENSG00000092529 CAPN3 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Included only because GO says positive regulation of NF-kappaB transcription factor activity. No indication of sequence specific DNA binding. IPR000169;IPR001300;IPR002048;IPR018247;IPR022682;IPR022683;IPR022684 825 calpain 3 [Source:HGNC Symbol;Acc:HGNC:1480] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Tim Hughes Laura Campitelli No $#ENSG00000092529#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IMP - PMID:18073330 $#ENSP00000336840#ENSG00000092529#ENST00000337571#Other#EF-hand_1, EF-hand_5, EF-hand_6, EF-hand_7, EF-han$#ENSP00000183936#ENSG00000092529#ENST00000349748#Other#Calpain_III, EF-hand_1, EF-hand_5, EF-hand_6, EF-h$#ENSP00000348667#ENSG00000092529#ENST00000356316#Other#EF-hand_1, EF-hand_5, EF-hand_6, EF-hand_7, EF-han$#ENSP00000350181#ENSG00000092529#ENST00000357568#Other#Calpain_III, Calpain_u2, EF-hand_1, EF-hand_5, EF-$#ENSP00000380349#ENSG00000092529#ENST00000397163#Other#Calpain_III, Calpain_u2, EF-hand_1, EF-hand_5, EF-$#ENSP00000380384#ENSG00000092529#ENST00000397200#Other#Calpain_III, Calpain_u2, EF-hand_1, EF-hand_5, EF-$#ENSP00000380387#ENSG00000092529#ENST00000397204#Other#EF-hand_1, EF-hand_5, EF-hand_6, EF-hand_7, EF-han$#ENSP00000456575#ENSG00000092529#ENST00000561817#Other#EF-hand_1, EF-hand_5, EF-hand_6, EF-hand_7, EF-han$#ENSP00000455254#ENSG00000092529#ENST00000569136#Other#EF-hand_1, EF-hand_5, EF-hand_6, EF-hand_7, EF-han$#ENSP00000457878#ENSG00000092529#ENST00000565559#Other#EF-hand_1, EF-hand_5, EF-hand_6, EF-hand_7, EF-han FALSE 1837 ENSG00000198286 CARD11 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Plasma-membrane protein possibly functioning in upstream signaling of NFKB (PMID: 12154360) IPR001315;IPR001478;IPR011029;IPR027417 84433 caspase recruitment domain family member 11 [Source:HGNC Symbol;Acc:HGNC:16393] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Jussi Taipale Arttu Jolma No $#ENSG00000198286#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IMP - PMID:12154360 $#ENSP00000380150#ENSG00000198286#ENST00000396946#Other#CARD, Guanylate_kin, PDZ$#ENSP00000347695#ENSG00000198286#ENST00000355508#Other#PDZ$#ENSP00000348779#ENSG00000198286#ENST00000356408#Other#CARD FALSE 1838 ENSG00000141527 CARD14 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR001315;IPR001478;IPR008144;IPR011029;IPR027417 79092 caspase recruitment domain family member 14 [Source:HGNC Symbol;Acc:HGNC:16446] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Matt Weirauch Pratyush Das No $#ENSG00000141527#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IMP - PMID:21302310 $#ENSP00000344549#ENSG00000141527#ENST00000344227#Other#CARD, Guanylate_kin, PDZ$#ENSP00000461806#ENSG00000141527#ENST00000570421#Other#CARD, PDZ$#ENSP00000461447#ENSG00000141527#ENST00000576785#Other#CARD FALSE 1839 ENSG00000138380 CARF Unknown Yes Known motif Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain Transfac-only motif. Major evidence is found in (PMID: 11832226). Cloned by Y1H and binding demonstrated by gel-shift. Mutant probes do not compete. DNA binding ability seems solid but motif is sketchy. IPR029309 79800 calcium responsive transcription factor [Source:HGNC Symbol;Acc:HGNC:14435] None not tested not tested None None No Yes No Yes 2a1, Lower confidence direct evidence Jussi Taipale Yimeng Yin No $#ENSG00000138380#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000138380#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:11832226 $#ENSP00000384006#ENSG00000138380#ENST00000402905#Other#ALS2CR8$#ENSP00000415948#ENSG00000138380#ENST00000434998#Other#ALS2CR8$#ENSP00000414644#ENSG00000138380#ENST00000438828#Other#ALS2CR8$#ENSP00000416812#ENSG00000138380#ENST00000444724#Other#ALS2CR8$#ENSP00000316224#ENSG00000138380#ENST00000320443#Other#ALS2CR8$#ENSP00000416160#ENSG00000138380#ENST00000414439#Other#ALS2CR8$#ENSP00000396221#ENSG00000138380#ENST00000428585#Other#ALS2CR8$#ENSP00000391617#ENSG00000138380#ENST00000414857#Other#$#ENSP00000387785#ENSG00000138380#ENST00000443740#Other# FALSE 1840 ENSG00000118412 CASP8AP2 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Pfam DBD match is a likely false-positive - did not produce a motif in PBM experiments IPR009057; 9994 caspase 8 associated protein 2 [Source:HGNC Symbol;Acc:HGNC:1510] None not tested Yes None None x Yes No No 4a, two or more datasets predict it as a TF Sam Lambert Tim Hughes No None $#ENSP00000478179#ENSG00000118412#ENST00000551025#Other#$#ENSP00000485346#ENSG00000118412#ENST00000552401#Other#$#ENSP00000485349#ENSG00000118412#ENST00000419040#Other# FALSE 1841 ENSG00000121691 CAT Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Protein that breaks down hydrogen peroxide None 847 Catalase None not tested Yes None None No No No Yes 5a, one of the source datasets predicts is as a TF Yimeng Yin Arttu Jolma No $#ENSG00000121691#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IEA - GO_REF:0000019$#ENSG00000121691#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IEA - GO_REF:0000019 $##ENSG00000121691##Other# FALSE 1842 ENSG00000078699 CBFA2T2 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None CBFA2T2 oligomerizes to form a scaffold upon which PRDM14 and OCT4 are stabilized on chromatin (PMID: 27281218) None 9139 Protein CBFA2T2 None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Pratyush Das Yimeng Yin No $#ENSG00000078699#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002 $##ENSG00000078699##Other# FALSE 1843 ENSG00000129993 CBFA2T3 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Co-repressor - does not contact DNA (PMID: 12559562; PMID: 15203199) IPR002893;IPR003894;IPR013289;IPR013292;IPR014896 863 CBFA2/RUNX1 translocation partner 3, core-binding factor, runt domain, alpha subunit 2, translocated None not tested not tested None None No No TF Gene_Transcription Factor Binding: tf co-factor binding_Non-specific DNA; Other; TF PPI_PMIDS:16287841;16407974 No 5a, one of the source datasets predicts is as a TF Pratyush Das Matt Weirauch No $#ENSG00000129993#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002 $##ENSG00000129993##Other# FALSE 1844 ENSG00000067955 CBFB Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif Only known motifs are from Transfac or HocoMoco - origin is uncertain CBFB augments the binding of RUNX to DNA, but does not itself bind DNA. Thus; it is a cofactor. Reviewed in (PMID:11105900). Two citations used by GO (PMID:8351518; PMID:9751756) do not demonstrate DNA binding. IPR003417; 865 core-binding factor, beta subunit [Source:HGNC Symbol;Acc:HGNC:1539] 1H9D not tested not tested None Structure is CBFB - RUNX1 heterodimer, CBFB does not contact DNA a Yes No Yes 2a1, Lower confidence direct evidence Tim Hughes Laura Campitelli No $#ENSG00000067955#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:8351518, PMID:9751756 $#ENSP00000290858#ENSG00000067955#ENST00000290858#Other#CBF_beta$#ENSP00000415151#ENSG00000067955#ENST00000412916#Other#CBF_beta$#ENSP00000462932#ENSG00000067955#ENST00000565389#Other#CBF_beta$#ENSP00000456637#ENSG00000067955#ENST00000564034#Other#CBF_beta FALSE 1845 ENSG00000110395 CBL Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Protein is a ubiquitin ligase IPR000449;IPR000980;IPR001841;IPR003153;IPR009060;IPR014741;IPR014742;IPR015940;IPR017907;IPR024159 867 Cbl proto-oncogene [Source:HGNC Symbol;Acc:HGNC:1541] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Arttu Jolma Laura Campitelli No $#ENSG00000110395#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:2030914 $#ENSP00000264033#ENSG00000110395#ENST00000264033#Other#Cbl_N, Cbl_N2, Cbl_N3, Prok-RING_4, UBA, zf-C3HC4,$#ENSP00000489556#ENSG00000110395#ENST00000634301#Other#$#ENSP00000490763#ENSG00000110395#ENST00000637974#Other#Cbl_N, Cbl_N2, Cbl_N3, Prok-RING_4, zf-C3HC4, zf-C FALSE 1846 ENSG00000105879 CBLL1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None E3-ubiquitin ligase involved in the regulation of cell adhesion (PMID: 11836526) IPR001841;IPR017907 79872 Cbl proto-oncogene like 1 [Source:HGNC Symbol;Acc:HGNC:21225] None Full not tested None None x No No No 5a, one of the source datasets predicts is as a TF Yimeng Yin Laura Campitelli No None $#ENSP00000222597#ENSG00000105879#ENST00000222597#Other#zf-C3HC4, zf-C3HC4_2, zf-C3HC4_3, zf-RING_5$#ENSP00000401277#ENSG00000105879#ENST00000440859#Other#zf-C3HC4, zf-C3HC4_2, zf-C3HC4_3, zf-RING_5$#ENSP00000401175#ENSG00000105879#ENST00000415884#Other#$#ENSP00000410615#ENSG00000105879#ENST00000420796#Other#zf-C3HC4, zf-C3HC4_2, zf-C3HC4_3, zf-RING_5 FALSE 1847 ENSG00000132024 CC2D1A Unknown Yes Likely to be sequence specific TF Monomer or homomultimer No motif None (PMID: 17714190) states that human Freud-1L bound specifically to its dual repressor element in the 5-HT1A receptor gene in vitro IPR000008;IPR006608 54862 coiled-coil and C2 domain containing 1A [Source:HGNC Symbol;Acc:HGNC:30237] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Tim Hughes Matt Weirauch No $#ENSG00000132024#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000132024#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019 $#ENSP00000313601#ENSG00000132024#ENST00000318003#Other#C2$#ENSP00000467526#ENSG00000132024#ENST00000589606#Other#C2$#ENSP00000466586#ENSG00000132024#ENST00000587508#Other#C2 FALSE 1848 ENSG00000154222 CC2D1B Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None (PMID: 19423080) says it binds a known locus in vivo, although lack of canonical DBDs suggests indirect DNA-binding IPR000008;IPR006608 200014 coiled-coil and C2 domain containing 1B [Source:HGNC Symbol;Acc:HGNC:29386] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Sam Lambert Laura Campitelli No $#ENSG00000154222#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000154222#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019 $#ENSP00000395921#ENSG00000154222#ENST00000438021#Other#C2$#ENSP00000284376#ENSG00000154222#ENST00000284376#Other#C2$#ENSP00000360642#ENSG00000154222#ENST00000371586#Other#C2$#ENSP00000402440#ENSG00000154222#ENST00000450942#Other#C2 FALSE 1849 ENSG00000177352 CCDC71 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif Has a putative AT-hook None IPR026695; 64925 coiled-coil domain containing 71 [Source:HGNC Symbol;Acc:HGNC:25760] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Pratyush Das Sam Lambert No None $#ENSP00000319006#ENSG00000177352#ENST00000321895#Other#CCDC71L FALSE 1850 ENSG00000129315 CCNT1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None General transcription machinery required to stimulate RNA pol II elongation (PMID: 16109377) IPR006671;IPR013763 904 cyclin T1 [Source:HGNC Symbol;Acc:HGNC:1599] None not tested not tested None None No No TF Gene Candidate__Other_PMIDS:9499409;12588988;12177005;12588988 No 5a, one of the source datasets predicts is as a TF Laura Campitelli Tim Hughes No None $##ENSG00000129315##Other# FALSE 1851 ENSG00000082258 CCNT2 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif Only known motifs are from Transfac or HocoMoco - origin is uncertain Has low or no sequence specificity (PMID: 27899659) IPR006671;IPR013763 905 cyclin T2 [Source:HGNC Symbol;Acc:HGNC:1600] None not tested not tested None None No Yes TF Gene_Transcription Factor Binding: tf co-factor binding_Co-activation_PMIDS:12037670;15563843 No 2a1, Lower confidence direct evidence Pratyush Das Jussi Taipale No None $#ENSP00000264157#ENSG00000082258#ENST00000264157#Other#Cyclin_N$#ENSP00000295238#ENSG00000082258#ENST00000295238#Other#Cyclin_N$#ENSP00000415120#ENSG00000082258#ENST00000438691#Other#$#ENSP00000387436#ENSG00000082258#ENST00000452521#Other# FALSE 1852 ENSG00000135218 CD36 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR002159;IPR005428 948 CD36 molecule [Source:HGNC Symbol;Acc:HGNC:1663] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Sam Lambert Laura Campitelli No None $#ENSP00000308165#ENSG00000135218#ENST00000309881#Other#CD36$#ENSP00000378268#ENSG00000135218#ENST00000394788#Other#CD36$#ENSP00000392298#ENSG00000135218#ENST00000419819#Other#CD36$#ENSP00000411411#ENSG00000135218#ENST00000432207#Other#CD36$#ENSP00000399421#ENSG00000135218#ENST00000435819#Other#CD36$#ENSP00000410371#ENSG00000135218#ENST00000438020#Other#CD36$#ENSP00000431296#ENSG00000135218#ENST00000534394#Other#CD36$#ENSP00000409762#ENSG00000135218#ENST00000428497#Other#CD36$#ENSP00000433659#ENSG00000135218#ENST00000482059#Other#CD36$#ENSP00000435698#ENSG00000135218#ENST00000488048#Other#CD36 FALSE 1853 ENSG00000101017 CD40 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Cell surface receptor of TNF-family IPR001368;IPR020435 958 CD40 molecule [Source:HGNC Symbol;Acc:HGNC:11919];Tumor necrosis factor receptor superfamily member None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Matt Weirauch Arttu Jolma No $#ENSG00000101017#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IMP - PMID:21410936 $#ENSP00000361350#ENSG00000101017#ENST00000372276#Other#TNFR_c6$#ENSP00000361359#ENSG00000101017#ENST00000372285#Other#TNFR_c6$#ENSP00000484074#ENSG00000101017#ENST00000620709#Other#TNFR_c6 FALSE 1854 ENSG00000102245 CD40LG Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR003263;IPR006052;IPR008983;IPR021184 959 CD40 ligand [Source:HGNC Symbol;Acc:HGNC:11935] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Matt Weirauch Yimeng Yin No $#ENSG00000102245#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IDA - PMID:15067037 $#ENSP00000359662#ENSG00000102245#ENST00000370628#Other#TNF$#ENSP00000359663#ENSG00000102245#ENST00000370629#Other#TNF FALSE 1855 ENSG00000094804 CDC6 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR003593;IPR015163;IPR016314;IPR027417 990 cell division cycle 6 [Source:HGNC Symbol;Acc:HGNC:1744] None not tested not tested None None No No TF Gene Candidate_Transcription Regulatory Activity: heterochromatin interaction/binding_DNA Binding_PMIDS:14667810 No 5a, one of the source datasets predicts is as a TF Yimeng Yin Matt Weirauch No None $##ENSG00000094804##Other# FALSE 1856 ENSG00000108465 CDK5RAP3 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR008491 80279 CDK5 regulatory subunit associated protein 3 [Source:HGNC Symbol;Acc:HGNC:18673] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Matt Weirauch Laura Campitelli No $#ENSG00000108465#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IMP - PMID:17785205, PMID:20228063 $#ENSP00000344683#ENSG00000108465#ENST00000338399#Other#DUF773$#ENSP00000438886#ENSG00000108465#ENST00000536708#Other#DUF773$#ENSP00000462886#ENSG00000108465#ENST00000578018#Other#DUF773$#ENSP00000463950#ENSG00000108465#ENST00000579175#Other#DUF773$#ENSP00000463431#ENSG00000108465#ENST00000583352#Other#DUF773, MbeD_MobD$#ENSP00000464286#ENSG00000108465#ENST00000583697#Other#DUF773 FALSE 1857 ENSG00000134058 CDK7 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000719;IPR002290;IPR008271;IPR011009;IPR017441 1022 cyclin dependent kinase 7 [Source:HGNC Symbol;Acc:HGNC:1778] None not tested not tested None None No No TF Gene Candidate__Co-activation_PMIDS:7566158;7761469;12379213 No 5a, one of the source datasets predicts is as a TF Matt Weirauch Jussi Taipale No None $##ENSG00000134058##Other# FALSE 1858 ENSG00000132964 CDK8 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Mediator component IPR000719;IPR002290;IPR008271;IPR011009;IPR017441 1024 cyclin dependent kinase 8 [Source:HGNC Symbol;Acc:HGNC:1779] None not tested not tested None None No No TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI; Transactivation_PMIDS:14749387;15546612 No 5a, one of the source datasets predicts is as a TF Laura Campitelli Yimeng Yin No None $##ENSG00000132964##Other# FALSE 1859 ENSG00000136807 CDK9 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Kinase protein. There is a structure with RNA (PDB: 5L1Z), where the CDK9 does not contact the RNA IPR000719;IPR002290;IPR008271;IPR011009;IPR017441 100616250 cyclin dependent kinase 9 [Source:HGNC Symbol;Acc:HGNC:1780] None not tested not tested None None No No TF Gene_Basal Transcription Factor; Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:10656684;12063565 No 5a, one of the source datasets predicts is as a TF Laura Campitelli Arttu Jolma No None $##ENSG00000136807##Other# FALSE 1860 ENSG00000124762 CDKN1A Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR003175 1026 cyclin dependent kinase inhibitor 1A [Source:HGNC Symbol;Acc:HGNC:1784] None not tested not tested None None No No TF Gene_Transcription Factor Binding: tf co-factor binding_DNA Binding_PMIDS:15743834 No 5a, one of the source datasets predicts is as a TF Sam Lambert Jussi Taipale No None $##ENSG00000124762##Other# FALSE 1861 ENSG00000147889 CDKN2A Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Protein binds to and inactivates NFKB1 (PMID: 10353611) IPR002110;IPR010868;IPR020683 1029 cyclin dependent kinase inhibitor 2A [Source:HGNC Symbol;Acc:HGNC:1787] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Matt Weirauch Arttu Jolma No $#ENSG00000147889#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IDA - PMID:10353611 $#ENSP00000307101#ENSG00000147889#ENST00000304494#Other#Ank, Ank_2, Ank_4, Ank_5$#ENSP00000418915#ENSG00000147889#ENST00000498124#Other#Ank, Ank_2, Ank_4, Ank_5$#ENSP00000462950#ENSG00000147889#ENST00000579755#Other#P19Arf_N$#ENSP00000467857#ENSG00000147889#ENST00000498628#Other#Ank, Ank_2, Ank_4, Ank_5$#ENSP00000467390#ENSG00000147889#ENST00000578845#Other#Ank, Ank_2, Ank_4, Ank_5$#ENSP00000464952#ENSG00000147889#ENST00000494262#Other#Ank, Ank_2, Ank_4, Ank_5$#ENSP00000464202#ENSG00000147889#ENST00000579122#Other#Ank, Ank_2, Ank_4, Ank_5 FALSE 1862 ENSG00000115816 CEBPZ Unknown Yes Known motif Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain None IPR005612;IPR016024 10153 CCAAT/enhancer binding protein zeta [Source:HGNC Symbol;Acc:HGNC:24218] None DBD and Full not tested None None a Yes TF Gene_Transcription Factor Binding: tf co-factor binding_DNA Binding_PMIDS:2247079 Yes 2a1, Lower confidence direct evidence Yimeng Yin Tim Hughes No $#ENSG00000115816#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:2247079 $#ENSP00000234170#ENSG00000115816#ENST00000234170#Other#CBF, Cnd1$#ENSP00000391881#ENSG00000115816#ENST00000446769#Other# FALSE 1863 ENSG00000159409 CELF3 Unknown No ssDNA/RNA binding Not a DNA binding protein No motif None Is a well established RBP IPR000504 11189 CUGBP, Elav-like family member 3 [Source:HGNC Symbol;Acc:HGNC:11967] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Pratyush Das Arttu Jolma No None $#ENSP00000290583#ENSG00000159409#ENST00000290583#Other#$#ENSP00000290585#ENSG00000159409#ENST00000290585#Other#$#ENSP00000402503#ENSG00000159409#ENST00000420342#Other# FALSE 1864 ENSG00000115163 CENPA Unknown Yes Likely to be sequence specific TF Low specificity DNA-binding protein No motif None Histone like protein. Binds DNA in the crystal structure (PDB: 3AN2). None None centromere protein A 3AN2 not tested not tested None Histone like protein. Binds DNA in the crystal structure (PDB: 3AN2). No No No No New proteins added based on PDB entry Arttu Jolma Sam Lambert No None None FALSE 1865 ENSG00000175279 CENPS Unknown Yes Likely to be sequence specific TF Low specificity DNA-binding protein No motif None Binds DNA in the crystal structure (PDB: 4NDY) in heterodimeric complex with CENPX. Protein complex has many contacts with the backbone, but only a few with the bases. None None centromere protein S 4NDY not tested not tested None Binds DNA in the crystal structure (PDB: 4NDY) in heterodimeric complex with CENPX. Protein complex has many contacts with the backbone, but only a few with the bases. No No No No New proteins added based on PDB entry Arttu Jolma Sam Lambert No None None FALSE 1866 ENSG00000102901 CENPT Unknown Yes Likely to be sequence specific TF Low specificity DNA-binding protein No motif None Contains an archaeal histone-like fold (CBF_NFY). but at best would have low sequence specificity. Known role in centromere assembly and lack of known sequence specificity suggest that it is unlikely to be a sequence specific TF. IPR009072; 80152 centromere protein T [Source:HGNC Symbol;Acc:HGNC:25787] None Full not tested None None c No No No 5a, one of the source datasets predicts is as a TF Tim Hughes Matt Weirauch No None $#ENSP00000400140#ENSG00000102901#ENST00000440851#Other#Bromo_TP, CBFD_NFYB_HMF, CENP-S, CENP-T_C, CENP-T_$#ENSP00000457810#ENSG00000102901#ENST00000562787#Other#Bromo_TP, CBFD_NFYB_HMF, CENP-S, CENP-T_C, CENP-T_ FALSE 1867 ENSG00000169689 CENPX Unknown Yes Likely to be sequence specific TF Low specificity DNA-binding protein No motif None Binds DNA in the crystal structure (PDB: 4NDY) in heterodimeric complex with CENPS. Protein complex has many contacts with the backbone, but only a few with the bases. None None Centromere protein X 4NDY not tested not tested None Binds DNA in the crystal structure (PDB: 4NDY) in heterodimeric complex with CENPS. Protein complex has many contacts with the backbone, but only a few with the bases. No No No No New proteins added based on PDB entry Arttu Jolma Sam Lambert No None None FALSE 1868 ENSG00000003402 CFLAR Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR001309;IPR001875;IPR011029;IPR011600;IPR015917 8837 CASP8 and FADD like apoptosis regulator [Source:HGNC Symbol;Acc:HGNC:1876] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Yimeng Yin Jussi Taipale No $#ENSG00000003402#GO:0051092#positive regulation of NF-kappaB transcription factor activity#ISS - GO_REF:0000024 $#ENSP00000312455#ENSG00000003402#ENST00000309955#Other#DED, Peptidase_C14$#ENSP00000339335#ENSG00000003402#ENST00000341222#Other#DED$#ENSP00000345807#ENSG00000003402#ENST00000341582#Other#DED, Peptidase_C14$#ENSP00000378580#ENSG00000003402#ENST00000395148#Other#DED$#ENSP00000399420#ENSG00000003402#ENST00000423241#Other#DED, Peptidase_C14$#ENSP00000406775#ENSG00000003402#ENST00000440180#Other#DED$#ENSP00000411535#ENSG00000003402#ENST00000457277#Other#DED, Peptidase_C14$#ENSP00000339326#ENSG00000003402#ENST00000340870#Other#DED, Peptidase_C14$#ENSP00000413270#ENSG00000003402#ENST00000443227#Other#DED, Peptidase_C14$#ENSP00000469917#ENSG00000003402#ENST00000462763#Other#DED$#ENSP00000471749#ENSG00000003402#ENST00000470178#Other#DED$#ENSP00000471805#ENSG00000003402#ENST00000479953#Other#DED, Peptidase_C14$#ENSP00000409570#ENSG00000003402#ENST00000425030#Other#DED$#ENSP00000391029#ENSG00000003402#ENST00000433445#Other#DED$#ENSP00000411897#ENSG00000003402#ENST00000441224#Other#DED, HTH_5$#ENSP00000469608#ENSG00000003402#ENST00000494258#Other#DED FALSE 1869 ENSG00000163320 CGGBP1 Unknown Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Binds unstable triplet repeat 5-d(CGG)n-3 in the human FMR1 gene (PMID: 9201980) IPR033375 8545 CGG triplet repeat binding protein 1 [Source:HGNC Symbol;Acc:HGNC:1888];CGG triplet repeat-binding p None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Laura Campitelli Pratyush Das No $#ENSG00000163320#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IDA - PMID:10692448 | IMP - PMID:10692448 $#ENSP00000381428#ENSG00000163320#ENST00000309534#Other#AKAP95, Mei5, zf-C2H2_2$#ENSP00000418769#ENSG00000163320#ENST00000462901#Other#AKAP95, Mei5, zf-C2H2_2$#ENSP00000420374#ENSG00000163320#ENST00000482016#Other#AKAP95, Mei5, zf-C2H2_2$#ENSP00000381429#ENSG00000163320#ENST00000398392#Other#AKAP95, Mei5, zf-C2H2_2 FALSE 1870 ENSG00000106554 CHCHD3 Unknown Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Alias FLJ20420 can specially bind the hBAG-1 promoter region by EMSA and ChIP assays (PMID: 22567091) IPR007964 54927 coiled-coil-helix-coiled-coil-helix domain containing 3 [Source:HGNC Symbol;Acc:HGNC:21906];MICOS co None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Pratyush Das Yimeng Yin No $#ENSG00000106554#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IDA - PMID:22567091 $#ENSP00000262570#ENSG00000106554#ENST00000262570#Other#CHCH, DUF737$#ENSP00000389297#ENSG00000106554#ENST00000448878#Other#CHCH, DUF737 FALSE 1871 ENSG00000153922 CHD1 Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif Has a putative AT-hook (PMID: 22033927) discusses and presents a crystal structure with DNA. The Chd1 chromatin remodeler possesses a C-terminal DNA-binding domain that is required for efficient nucleosome sliding and believed to be essential for sensing the length of DNA flanking the nucleosome core. Recognizes backbone only, so it has low specificity. IPR000330;IPR000953;IPR001650;IPR014001;IPR016197;IPR023779;IPR023780;IPR025260;IPR027417; 1105 chromodomain helicase DNA binding protein 1 [Source:HGNC Symbol;Acc:HGNC:1915] 3TED Full not tested None Structure is for yeast homolog, based on PMID:16263726 the protein recognizes methylated H3K4, but the yeast homolog doesnt x No No No 3a, decent circumstantial evidence for its role as Jussi Taipale Yimeng Yin No None $#ENSP00000284049#ENSG00000153922#ENST00000284049#Other#CHDCT2, Chromo, DUF4208, Helicase_C, ResIII, SLIDE$#ENSP00000479403#ENSG00000153922#ENST00000511067#Other#DUF4208$#ENSP00000483667#ENSG00000153922#ENST00000614616#Other#CHDCT2, Chromo, DUF4208, Helicase_C, ResIII, SLIDE FALSE 1872 ENSG00000124177 CHD6 Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None ATP dependent helicase (PMID: 17027977), so it has some affinity for DNA IPR000330;IPR000953;IPR001650;IPR002464;IPR006576;IPR014001;IPR016197;IPR023780;IPR027417; 84181 chromodomain helicase DNA binding protein 6 [Source:HGNC Symbol;Acc:HGNC:19057] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Jussi Taipale Pratyush Das No None $#ENSP00000308684#ENSG00000124177#ENST00000309279#Other#CHDCT2, Chromo, ResIII, SNF2_N$#ENSP00000362319#ENSG00000124177#ENST00000373222#Other#$#ENSP00000362330#ENSG00000124177#ENST00000373233#Other#CHDCT2, Chromo, DEAD, HDA2-3, Helicase_C, ResIII, $#ENSP00000392503#ENSG00000124177#ENST00000440647#Other# FALSE 1873 ENSG00000171316 CHD7 Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None Helicase and chromodomain IPR000330;IPR000953;IPR001650;IPR006576;IPR014001;IPR016197;IPR023780;IPR027417 55636 chromodomain helicase DNA binding protein 7 [Source:HGNC Symbol;Acc:HGNC:20626] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Yimeng Yin Arttu Jolma No None $#ENSP00000437061#ENSG00000171316#ENST00000524602#Other#BRK$#ENSP00000436492#ENSG00000171316#ENST00000526846#Other#$#ENSP00000392028#ENSG00000171316#ENST00000423902#Other#BRK, CHDCT2, Chromo, Helicase_C, ResIII, SNF2_N$#ENSP00000436027#ENSG00000171316#ENST00000525508#Other#Chromo, DEAD, ResIII, SNF2_N FALSE 1874 ENSG00000177200 CHD9 Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif Has a putative AT-hook None IPR000330;IPR000953;IPR001650;IPR006576;IPR014001;IPR016197;IPR023780;IPR027417 80205 chromodomain helicase DNA binding protein 9 [Source:HGNC Symbol;Acc:HGNC:25701] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Pratyush Das Yimeng Yin No None $#ENSP00000381522#ENSG00000177200#ENST00000398510#Other#BRK, CHDCT2, Chromo, DEAD, Helicase_C, Peptidase_M$#ENSP00000455307#ENSG00000177200#ENST00000564845#Other#BRK, CHDCT2, Chromo, DEAD, Helicase_C, ResIII, SNF$#ENSP00000456793#ENSG00000177200#ENST00000565832#Other#$#ENSP00000457466#ENSG00000177200#ENST00000566029#Other#BRK, CHDCT2, Chromo, DEAD, Helicase_C, ResIII, SNF$#ENSP00000482842#ENSG00000177200#ENST00000622617#Other#BRK, cIII$#ENSP00000457929#ENSG00000177200#ENST00000563410#Other#$#ENSP00000456415#ENSG00000177200#ENST00000565442#Other#$#ENSP00000460155#ENSG00000177200#ENST00000562785#Other# FALSE 1875 ENSG00000187446 CHP1 Unknown No ssDNA/RNA binding Low specificity DNA-binding protein No motif None According to EMSA, binds RNA strongly, and dsDNA weakly (PMID: 22727667) IPR002048;IPR011992 11261 calcineurin like EF-hand protein 1 [Source:HGNC Symbol;Acc:HGNC:17433] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Laura Campitelli Pratyush Das No $#ENSG00000187446#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IDA - PMID:10593895 $#ENSP00000335632#ENSG00000187446#ENST00000334660#Other#EF-hand_1, EF-hand_5, EF-hand_6, EF-hand_7, EF-han$#ENSP00000453392#ENSG00000187446#ENST00000560965#Other#EF-hand_1, EF-hand_6, EF-hand_7$#ENSP00000454007#ENSG00000187446#ENST00000560397#Other#EF-hand_1, EF-hand_5, EF-hand_6, EF-hand_7, EF-han FALSE 1876 ENSG00000104472 CHRAC1 Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None None IPR003958;IPR009072 54108 chromatin accessibility complex 1 [Source:HGNC Symbol;Acc:HGNC:13544] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Matt Weirauch Sam Lambert No None $#ENSP00000220913#ENSG00000104472#ENST00000220913#Other#CBFD_NFYB_HMF$#ENSP00000430484#ENSG00000104472#ENST00000518971#Other#$#ENSP00000428697#ENSG00000104472#ENST00000519533#Other#CBFD_NFYB_HMF$#ENSP00000430003#ENSG00000104472#ENST00000519618#Other# FALSE 1877 ENSG00000213341 CHUK Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Kinase that operates upstream in the signalling cascade that leads to NFKB IPR000719;IPR002290;IPR008271;IPR011009;IPR017441;IPR022007 1147 conserved helix-loop-helix ubiquitous kinase [Source:HGNC Symbol;Acc:HGNC:1974] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Sam Lambert Arttu Jolma No $#ENSG00000213341#GO:0051092#positive regulation of NF-kappaB transcription factor activity#TAS - PMID:18626576, Reactome:R-HSA-445989 $#ENSP00000359424#ENSG00000213341#ENST00000370397#Other#IKKbetaNEMObind, Kdo, Pkinase, Pkinase_Tyr FALSE 1878 ENSG00000258289 CHURC1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif Only known motifs are from Transfac or HocoMoco - origin is uncertain Most recent work has conclusively shown it does not bind DNA (PMID: 17610897), refuting a previous study (PMID: 14651851) IPR009508 91612 churchill domain containing 1 [Source:HGNC Symbol;Acc:HGNC:20099] None not tested not tested None None No Yes No No 2a1, Lower confidence direct evidence Laura Campitelli Arttu Jolma No None $#ENSP00000448050#ENSG00000258289#ENST00000549115#Other#Churchill, zf-RRPl_C4$#ENSP00000450144#ENSG00000258289#ENST00000552002#Other#Churchill, zf-RRPl_C4$#ENSP00000450165#ENSG00000258289#ENST00000548752#Other#Churchill$#ENSP00000446610#ENSG00000258289#ENST00000551093#Other#Churchill$#ENSP00000446697#ENSG00000258289#ENST00000551947#Other#Churchill$#ENSP00000475473#ENSG00000258289#ENST00000607599#Other#Churchill$#ENSP00000449184#ENSG00000258289#ENST00000547625#Other#Churchill FALSE 1879 ENSG00000185043 CIB1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR002048;IPR011992;IPR018247 10519 calcium and integrin binding 1 [Source:HGNC Symbol;Acc:HGNC:16920] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Pratyush Das Yimeng Yin No $#ENSG00000185043#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IMP - PMID:19854831 $#ENSP00000333873#ENSG00000185043#ENST00000328649#Other#EF-hand_1, EF-hand_5, EF-hand_6, EF-hand_7, EF-han$#ENSP00000479860#ENSG00000185043#ENST00000612800#Other#EF-hand_1, EF-hand_5, EF-hand_6, EF-hand_7, EF-han FALSE 1880 ENSG00000179583 CIITA Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Chromatin modifier IPR001611;IPR003590;IPR007111;IPR008095;IPR025875;IPR027417 4261 class II, major histocompatibility complex, transactivator [Source:HGNC Symbol;Acc:HGNC:7067] None not tested not tested None None No No TF Gene_Transcription Factor Binding: tf co-factor binding_DNA Binding; Transactivation_PMIDS:12506036 No 5a, one of the source datasets predicts is as a TF Sam Lambert Jussi Taipale No None $##ENSG00000179583##Other# FALSE 1881 ENSG00000138433 CIR1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR019339 9541 corepressor interacting with RBPJ, 1 [Source:HGNC Symbol;Acc:HGNC:24217] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Pratyush Das Matt Weirauch No $#ENSG00000138433#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:9874765$#ENSG00000138433#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#TAS - PMID:18663143 $#ENSP00000339723#ENSG00000138433#ENST00000342016#Other#Cir_N$#ENSP00000367211#ENSG00000138433#ENST00000377973#Other#zf-CCHC_6 FALSE 1882 ENSG00000125931 CITED1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Known co-activator. GO says its sequence-specific DNA binding transcription factor activity NAS - PMID: 8901575 but this reference does not show this. IPR007576 4435 Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1 [Source:HGNC Symbol; None not tested not tested None None No No TF Gene_Transcription Factor Binding: tf co-factor binding_Transactivation_PMIDS:9434189;10722728 Yes 4a, two or more datasets predict it as a TF Matt Weirauch Tim Hughes No $#ENSG00000125931#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:8901575 $#ENSP00000246139#ENSG00000125931#ENST00000246139#Other#CITED$#ENSP00000362721#ENSG00000125931#ENST00000373619#Other#CITED$#ENSP00000414781#ENSG00000125931#ENST00000417400#Other#CITED$#ENSP00000391407#ENSG00000125931#ENST00000427412#Other#CITED$#ENSP00000407496#ENSG00000125931#ENST00000429794#Other#CITED$#ENSP00000388548#ENSG00000125931#ENST00000431381#Other#CITED$#ENSP00000403274#ENSG00000125931#ENST00000445983#Other#CITED$#ENSP00000405765#ENSG00000125931#ENST00000450875#Other#$#ENSP00000401764#ENSG00000125931#ENST00000453707#Other#CITED FALSE 1883 ENSG00000164442 CITED2 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR007576 10370 Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2 [Source:HGNC Symbol; None not tested not tested None None No No TF Gene_Transcription Factor Binding: tf co-factor binding_Co-activation; TF PPI; Transactivation_PMIDS:9434189;11044621;12778114 Yes 4a, two or more datasets predict it as a TF Yimeng Yin Laura Campitelli No $#ENSG00000164442#GO:0003700#sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024 $#ENSP00000356623#ENSG00000164442#ENST00000367651#Other#CITED$#ENSP00000479918#ENSG00000164442#ENST00000618718#Other#CITED$#ENSP00000442831#ENSG00000164442#ENST00000536159#Other#CITED$#ENSP00000444198#ENSG00000164442#ENST00000537332#Other#CITED FALSE 1884 ENSG00000179862 CITED4 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Transcriptional co-factor IPR007576 163732 Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 4 [Source:HGNC Symbol; None not tested not tested None None No No TF Gene_Transcription Factor Binding: tf co-factor binding_Co-activation_PMIDS:11744733 No 5a, one of the source datasets predicts is as a TF Sam Lambert Jussi Taipale No None $##ENSG00000179862##Other# FALSE 1885 ENSG00000148337 CIZ1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Presence of zf-C2H2_jaz domain suggests that its likely a dsRNA binding protein IPR000690;IPR003604;IPR007087;IPR015880;IPR022755; 25792 CDKN1A interacting zinc finger protein 1 [Source:HGNC Symbol;Acc:HGNC:16744] None DBD not tested None None b No No No 5a, one of the source datasets predicts is as a TF Laura Campitelli Sam Lambert No None $#ENSP00000362029#ENSG00000148337#ENST00000372938#Other#zf-C2H2_2, zf-C2H2_jaz$#ENSP00000362045#ENSG00000148337#ENST00000372954#Other#zf-C2H2_2, zf-C2H2_jaz$#ENSP00000377232#ENSG00000148337#ENST00000393608#Other#zf-C2H2_2, zf-C2H2_jaz$#ENSP00000398011#ENSG00000148337#ENST00000415526#Other#zf-C2H2_2, zf-C2H2_jaz$#ENSP00000362039#ENSG00000148337#ENST00000372948#Other#zf-C2H2_2, zf-C2H2_jaz$#ENSP00000489129#ENSG00000148337#ENST00000471839#Other#zf-C2H2_2, zf-C2H2_4, zf-C2H2_jaz$#ENSP00000439244#ENSG00000148337#ENST00000538431#Other#zf-C2H2_2, zf-C2H2_jaz$#ENSP00000486816#ENSG00000148337#ENST00000629610#Other#zf-C2H2_2, zf-C2H2_jaz$#ENSP00000321780#ENSG00000148337#ENST00000324544#Other#$#ENSP00000407265#ENSG00000148337#ENST00000420484#Other# FALSE 1886 ENSG00000120885 CLU Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Included only because GO says positive regulation of NF-kappaB transcription factor activity, but there is no DBD and no evidence of DNA binding. IPR000753;IPR016014;IPR016015;IPR016016 102465508 clusterin [Source:HGNC Symbol;Acc:HGNC:2095] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Matt Weirauch Tim Hughes No $#ENSG00000120885#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IMP - PMID:20068069 $#ENSP00000315130#ENSG00000120885#ENST00000316403#Other#Clusterin$#ENSP00000385419#ENSG00000120885#ENST00000405140#Other#Clusterin$#ENSP00000429620#ENSG00000120885#ENST00000523500#Other#Clusterin$#ENSP00000427868#ENSG00000120885#ENST00000519472#Other#Clusterin, RE_AlwI$#ENSP00000428033#ENSG00000120885#ENST00000521770#Other#Clusterin, OGFr_N$#ENSP00000430821#ENSG00000120885#ENST00000522098#Other#Clusterin$#ENSP00000431026#ENSG00000120885#ENST00000519742#Other#Clusterin, RE_AlwI, T3SSipB$#ENSP00000429881#ENSG00000120885#ENST00000520491#Other#Clusterin, RE_AlwI, T3SSipB$#ENSP00000429087#ENSG00000120885#ENST00000522238#Other#$#ENSP00000428779#ENSG00000120885#ENST00000522413#Other#Clusterin, RE_AlwI, T3SSipB$#ENSP00000428526#ENSG00000120885#ENST00000523396#Other#Clusterin, RE_AlwI$#ENSP00000431070#ENSG00000120885#ENST00000523589#Other#Clusterin, RE_AlwI FALSE 1887 ENSG00000174600 CMKLR1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Protein is a G protein-coupled receptor for the chemoattractant adipokine chemerin IPR000276;IPR002258;IPR017452 1240 chemerin chemokine-like receptor 1 [Source:HGNC Symbol;Acc:HGNC:2121] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Yimeng Yin Arttu Jolma No $#ENSG00000174600#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IDA - PMID:15753205 $#ENSP00000449716#ENSG00000174600#ENST00000550402#Other#7tm_1$#ENSP00000447579#ENSG00000174600#ENST00000552995#Other#7tm_1$#ENSP00000311733#ENSG00000174600#ENST00000312143#Other#7tm_1$#ENSP00000401293#ENSG00000174600#ENST00000412676#Other#7tm_1$#ENSP00000448925#ENSG00000174600#ENST00000550573#Other#7tm_1 FALSE 1888 ENSG00000169714 CNBP Unknown No ssDNA/RNA binding Not a DNA binding protein No motif None CNBP has a specificity for single-stranded DNA (PMID: 2562787) IPR001878 7555 CCHC-type zinc finger nucleic acid binding protein [Source:HGNC Symbol;Acc:HGNC:13164];Cellular nucl None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Sam Lambert Jussi Taipale No $#ENSG00000169714#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:2562787 $#ENSP00000410619#ENSG00000169714#ENST00000422453#Other#zf-CCHC, zf-CCHC_2, zf-CCHC_3, zf-CCHC_4, zf-CCHC_$#ENSP00000400444#ENSG00000169714#ENST00000446936#Other#zf-CCHC, zf-CCHC_2, zf-CCHC_3, zf-CCHC_4, zf-CCHC_$#ENSP00000399488#ENSG00000169714#ENST00000451728#Other#zf-CCHC, zf-CCHC_2, zf-CCHC_3, zf-CCHC_4, zf-CCHC_$#ENSP00000421323#ENSG00000169714#ENST00000502976#Other#zf-CCHC, zf-CCHC_2, zf-CCHC_3, zf-CCHC_4, zf-CCHC_$#ENSP00000410769#ENSG00000169714#ENST00000441626#Other#zf-CCHC, zf-CCHC_2, zf-CCHC_3, zf-CCHC_4, zf-CCHC_$#ENSP00000426223#ENSG00000169714#ENST00000500450#Other#zf-CCHC, zf-CCHC_2, zf-CCHC_3, zf-CCHC_4, zf-CCHC_$#ENSP00000422110#ENSG00000169714#ENST00000504813#Other#zf-CCHC, zf-CCHC_2, zf-CCHC_3, zf-CCHC_4, zf-CCHC_ FALSE 1889 ENSG00000088038 CNOT3 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif Only known motifs are from Transfac or HocoMoco - origin is uncertain Part of complex that de-adenylates mRNA molecules (PMID: 27746116) IPR007207;IPR007282;IPR012270 4849 CCR4-NOT transcription complex subunit 3 [Source:HGNC Symbol;Acc:HGNC:7879] None not tested not tested None None No No TF Gene_Transcription Factor Binding: tf co-factor binding_DNA Binding_PMIDS:10637334;15601868 No 5a, one of the source datasets predicts is as a TF Arttu Jolma Tim Hughes No None $##ENSG00000088038##Other# FALSE 1890 ENSG00000080802 CNOT4 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Regulates transcription through ubiquitination of TFIID (PMID:11823428). Only contains RRM domains, with no DBDs. None None CCR4-NOT transcription complex subunit 4 None not tested not tested None Regulates transcription through ubiquitination of TFIID (PMID:11823428). Only contains RRM domains, with no DBDs. No No No No Protein added after initial stage, no initial assesment Arttu Jolma Sam Lambert No None None FALSE 1891 ENSG00000198791 CNOT7 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None (PMID:9820826) does not support DNA-binding IPR006941;IPR012337 29883 CCR4-NOT transcription complex subunit 7 [Source:HGNC Symbol;Acc:HGNC:14101] None not tested not tested None None No No Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0 Yes 4a, two or more datasets predict it as a TF Yimeng Yin Arttu Jolma No $#ENSG00000198791#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:9820826 $#ENSP00000355279#ENSG00000198791#ENST00000361272#Other#CAF1$#ENSP00000430263#ENSG00000198791#ENST00000518541#Other#CAF1$#ENSP00000428147#ENSG00000198791#ENST00000519918#Other#CAF1$#ENSP00000429093#ENSG00000198791#ENST00000523917#Other#CAF1$#ENSP00000430160#ENSG00000198791#ENST00000524358#Other#CAF1 FALSE 1892 ENSG00000155508 CNOT8 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Deadenylase that probably regulates genes post-transcriptionally by controlling mRNA stability (PMID: 19605561) IPR006941;IPR012337 9337 CCR4-NOT transcription complex subunit 8 [Source:HGNC Symbol;Acc:HGNC:9207] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Laura Campitelli Arttu Jolma No $#ENSG00000155508#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:10036195 $#ENSP00000285896#ENSG00000155508#ENST00000285896#Other#CAF1$#ENSP00000384747#ENSG00000155508#ENST00000403027#Other#CAF1$#ENSP00000429882#ENSG00000155508#ENST00000521583#Other#CAF1$#ENSP00000430493#ENSG00000155508#ENST00000517876#Other#CAF1$#ENSP00000430833#ENSG00000155508#ENST00000519404#Other#CAF1$#ENSP00000428305#ENSG00000155508#ENST00000520671#Other#CAF1$#ENSP00000431034#ENSG00000155508#ENST00000521450#Other#CAF1$#ENSP00000428565#ENSG00000155508#ENST00000523698#Other#CAF1$#ENSP00000429576#ENSG00000155508#ENST00000524105#Other#CAF1$#ENSP00000429108#ENSG00000155508#ENST00000519211#Other#CAF1$#ENSP00000428842#ENSG00000155508#ENST00000519394#Other#CAF1 FALSE 1893 ENSG00000173163 COMMD1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR009886;IPR017920 150684 copper metabolism domain containing 1 [Source:HGNC Symbol;Acc:HGNC:23024];COMM domain-containing pro None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Yimeng Yin Sam Lambert No $#ENSG00000173163#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IDA - PMID:15799966, PMID:16573520 | IMP - PMID:17 $#ENSP00000308236#ENSG00000173163#ENST00000311832#Other#COMMD1_N, COMM_domain$#ENSP00000410050#ENSG00000173163#ENST00000444166#Other#$#ENSP00000413207#ENSG00000173163#ENST00000427417#Other#COMM_domain$#ENSP00000401236#ENSG00000173163#ENST00000458337#Other#COMM_domain FALSE 1894 ENSG00000188243 COMMD6 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR009886;IPR017920 170622 COMM domain containing 6 [Source:HGNC Symbol;Acc:HGNC:24015] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Yimeng Yin Laura Campitelli No $#ENSG00000188243#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IDA - PMID:16573520 $#ENSP00000385660#ENSG00000188243#ENST00000406936#Other#COMM_domain$#ENSP00000348054#ENSG00000188243#ENST00000355801#Other#COMM_domain$#ENSP00000366845#ENSG00000188243#ENST00000377619#Other#COMM_domain FALSE 1895 ENSG00000149600 COMMD7 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR009886;IPR017920 149951 COMM domain containing 7 [Source:HGNC Symbol;Acc:HGNC:16223] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Yimeng Yin Jussi Taipale No $#ENSG00000149600#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IDA - PMID:15799966 $#ENSP00000278980#ENSG00000149600#ENST00000278980#Other#COMM_domain$#ENSP00000395339#ENSG00000149600#ENST00000446419#Other#COMM_domain$#ENSP00000476443#ENSG00000149600#ENST00000474815#Other# FALSE 1896 ENSG00000166200 COPS2 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000717;IPR013143 9318 COP9 signalosome subunit 2 [Source:HGNC Symbol;Acc:HGNC:30747] None not tested not tested None None x No TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:10991940;12522100 No 4a, two or more datasets predict it as a TF Sam Lambert Arttu Jolma No None $#ENSP00000299259#ENSG00000166200#ENST00000299259#Other#PCI$#ENSP00000373553#ENSG00000166200#ENST00000388901#Other#PCI$#ENSP00000452944#ENSG00000166200#ENST00000558843#Other#mRNA_stabil$#ENSP00000443664#ENSG00000166200#ENST00000542928#Other#PCI FALSE 1897 ENSG00000141030 COPS3 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Kinase that phosphorylates JUN and possibly other TFs IPR000717; 8533 COP9 signalosome subunit 3 [Source:HGNC Symbol;Acc:HGNC:2239] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Arttu Jolma Pratyush Das No None $#ENSP00000268717#ENSG00000141030#ENST00000268717#Other#PCI, RasGEF, TPR_1$#ENSP00000437606#ENSG00000141030#ENST00000539941#Other#PCI, RasGEF, TPR_1$#ENSP00000466153#ENSG00000141030#ENST00000579716#Other# FALSE 1898 ENSG00000138663 COPS4 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000717; 51138 COP9 signalosome subunit 4 [Source:HGNC Symbol;Acc:HGNC:16702] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Jussi Taipale Laura Campitelli No None $#ENSP00000264389#ENSG00000138663#ENST00000264389#Other#PCI$#ENSP00000425976#ENSG00000138663#ENST00000509093#Other#PCI FALSE 1899 ENSG00000214575 CPEB1 Unknown Yes Known motif Monomer or homomultimer High-throughput in vitro None HT-SELEX motif could be an artefact of ssDNA binding activity, as CPEB1 is a well-characterized RNA-binding protein. Could not find evidence of CPEB1 DNA-binding activity in the literature IPR000504; 64506 cytoplasmic polyadenylation element binding protein 1 [Source:HGNC Symbol;Acc:HGNC:21744] None not tested not tested None Binding probably to single stranded DNA in HT-SELEX, is an verified RNA-binding protein No Yes No No 1a1, Direct HQ evidence Sam Lambert Yimeng Yin No None $#ENSP00000477715#ENSG00000214575#ENST00000615198#Other#CEBP1_N, CEBP_ZZ$#ENSP00000477557#ENSG00000214575#ENST00000617462#Other#CEBP1_N, CEBP_ZZ$#ENSP00000478598#ENSG00000214575#ENST00000617958#Other#CEBP1_N, CEBP_ZZ$#ENSP00000483590#ENSG00000214575#ENST00000618449#Other#CEBP1_N, CEBP_ZZ$#ENSP00000483857#ENSG00000214575#ENST00000611163#Other#CEBP1_N, CEBP_ZZ$#ENSP00000479625#ENSG00000214575#ENST00000616959#Other#CEBP1_N, CEBP_ZZ$#ENSP00000484549#ENSG00000214575#ENST00000620182#Other#CEBP1_N, CEBP_ZZ$#ENSP00000455044#ENSG00000214575#ENST00000568994#Other#CEBP1_N FALSE 1900 ENSG00000005339 CREBBP Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None CREBBP is a likely transcriptional co-activator based on its domains and previous experimental evidence. It has previously been shown to not bind DNA sequence-specifically (PMID: 21539536) IPR000197;IPR000433;IPR001487;IPR003101;IPR009110;IPR010303;IPR011011;IPR013178;IPR014744;IPR018359 1387 CREB binding protein [Source:HGNC Symbol;Acc:HGNC:2348] None not tested not tested None None No No TF Gene Candidate__Co-activation_PMIDS:8413673 Yes 4a, two or more datasets predict it as a TF Sam Lambert Laura Campitelli No $#ENSG00000005339#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:21539536$#ENSG00000005339#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:7913207 $#ENSP00000262367#ENSG00000005339#ENST00000262367#Other#Bromodomain, Creb_binding, DUF902, HAT_KAT11, KIX,$#ENSP00000371502#ENSG00000005339#ENST00000382070#Other#Bromodomain, Creb_binding, DUF902, HAT_KAT11, KIX,$#ENSP00000459490#ENSG00000005339#ENST00000571826#Other#KIX$#ENSP00000490244#ENSG00000005339#ENST00000637492#Other#Vps36-NZF-N, ZZ FALSE 1901 ENSG00000143162 CREG1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Regulates transcription in tethering assays (PMID: 9710587). Unlikely to be a TF, based on the lack of a canonical DBD IPR012349;IPR014631 8804 cellular repressor of E1A stimulated genes 1 [Source:HGNC Symbol;Acc:HGNC:2351] None not tested not tested None None No No TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_DNA Binding_PMIDS:9710587 No 5a, one of the source datasets predicts is as a TF Sam Lambert Laura Campitelli No None $##ENSG00000143162##Other# FALSE 1902 ENSG00000105662 CRTC1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR024783;IPR024784;IPR024785 23373 CREB regulated transcription coactivator 1 [Source:HGNC Symbol;Acc:HGNC:16062] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Sam Lambert Yimeng Yin No $#ENSG00000105662#GO:0032793#positive regulation of CREB transcription factor activity#IBA - GO_REF:0000033 | ISS - GO_REF:0000024 $#ENSP00000323332#ENSG00000105662#ENST00000321949#Other#TORC_C, TORC_M, TORC_N$#ENSP00000345001#ENSG00000105662#ENST00000338797#Other#TORC_C, TORC_M, TORC_N$#ENSP00000468893#ENSG00000105662#ENST00000594658#Other#TORC_C, TORC_M$#ENSP00000469285#ENSG00000105662#ENST00000601916#Other#TORC_C, TORC_M FALSE 1903 ENSG00000160741 CRTC2 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif Only known motifs are from Transfac or HocoMoco - origin is uncertain CRTC2 binds CREB and does not make contacts with the DNA (PDB: 4HTM; PMID: 23213254) IPR024783;IPR024784;IPR024785 200186 CREB regulated transcription coactivator 2 [Source:HGNC Symbol;Acc:HGNC:27301] None not tested not tested None None No Yes No Yes 2a1, Lower confidence direct evidence Sam Lambert Yimeng Yin No $#ENSG00000160741#GO:0032793#positive regulation of CREB transcription factor activity#IBA - GO_REF:0000033 | ISS - GO_REF:0000024 $#ENSP00000357622#ENSG00000160741#ENST00000368633#Other#TORC_C, TORC_M, TORC_N$#ENSP00000357619#ENSG00000160741#ENST00000368630#Other#TORC_C, TORC_N FALSE 1904 ENSG00000140577 CRTC3 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Evidence showing that CRTC2, which resembles CERTC3, lacks DNA-binding acitvity. Its reasonable to speculate CRTC3 also lacks ability to bind to DNA IPR024783;IPR024784;IPR024785 64784 CREB regulated transcription coactivator 3 [Source:HGNC Symbol;Acc:HGNC:26148] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Sam Lambert Yimeng Yin No $#ENSG00000140577#GO:0032793#positive regulation of CREB transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000268184#ENSG00000140577#ENST00000268184#Other#TORC_C, TORC_M, TORC_N$#ENSP00000452640#ENSG00000140577#ENST00000560098#Other#TORC_N$#ENSP00000416573#ENSG00000140577#ENST00000420329#Other#TORC_C, TORC_M, TORC_N$#ENSP00000452676#ENSG00000140577#ENST00000558005#Other#TORC_M FALSE 1905 ENSG00000144655 CSRNP1 Unknown Yes Likely to be sequence specific TF Monomer or homomultimer No motif None All three paralogs (CSRNP1, CSRNP2, and CSRNP3) bind an AGAGTG consensus based on SELEX experiments (PMID: 17726538) IPR023260 64651 cysteine and serine rich nuclear protein 1 [Source:HGNC Symbol;Acc:HGNC:14300] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Pratyush Das Arttu Jolma Yes $#ENSG00000144655#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IEA - GO_REF:0000019$#ENSG00000144655#GO:0003700#sequence-specific DNA binding transcription factor activity#ISS - PMID:17726538 $#ENSP00000273153#ENSG00000144655#ENST00000273153#Other#CSRNP_N$#ENSP00000422532#ENSG00000144655#ENST00000514182#Other#CSRNP_N FALSE 1906 ENSG00000110925 CSRNP2 Unknown Yes Likely to be sequence specific TF Monomer or homomultimer No motif None All three paralogs (CSRNP1, CSRNP2, and CSRNP3) bind an AGAGTG consensus based on SELEX experiments (PMID: 17726538) IPR023260 81566 cysteine and serine rich nuclear protein 2 [Source:HGNC Symbol;Acc:HGNC:16006] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Tim Hughes Laura Campitelli Yes $#ENSG00000110925#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IEA - GO_REF:0000019$#ENSG00000110925#GO:0003700#sequence-specific DNA binding transcription factor activity#ISS - PMID:17726538 $#ENSP00000228515#ENSG00000110925#ENST00000228515#Other#CSRNP_N$#ENSP00000447983#ENSG00000110925#ENST00000548206#Other#CSRNP_N$#ENSP00000447657#ENSG00000110925#ENST00000548981#Other#CSRNP_N$#ENSP00000447065#ENSG00000110925#ENST00000552899#Other#CSRNP_N FALSE 1907 ENSG00000178662 CSRNP3 Unknown Yes Likely to be sequence specific TF Monomer or homomultimer No motif None All three paralogs (CSRNP1, CSRNP2, and CSRNP3) bind an AGAGTG consensus based on SELEX experiments (PMID: 17726538) IPR023260 80034 cysteine and serine rich nuclear protein 3 [Source:HGNC Symbol;Acc:HGNC:30729] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Laura Campitelli Arttu Jolma Yes $#ENSG00000178662#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IEA - GO_REF:0000019$#ENSG00000178662#GO:0003700#sequence-specific DNA binding transcription factor activity#ISS - PMID:17726538 $#ENSP00000344042#ENSG00000178662#ENST00000342316#Other#CSRNP_N, Nop14 FALSE 1908 ENSG00000159692 CTBP1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif Only known motifs are from Transfac or HocoMoco - origin is uncertain Transfac-only motif with no clear source. This is a known corepressor with a primary function in the Golgi. IPR006139;IPR006140;IPR029752;IPR029753 1487 C-terminal binding protein 1 [Source:HGNC Symbol;Acc:HGNC:2494] None not tested not tested None None No Yes TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_Co-activation_PMIDS:10567582;15834423 No 2a1, Lower confidence direct evidence Jussi Taipale Yimeng Yin No $#ENSG00000159692#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019 $#ENSP00000290921#ENSG00000159692#ENST00000290921#Other#2-Hacid_dh, 2-Hacid_dh_C, NAD_binding_2$#ENSP00000372411#ENSG00000159692#ENST00000382952#Other#2-Hacid_dh, 2-Hacid_dh_C, NAD_binding_2$#ENSP00000423872#ENSG00000159692#ENST00000510568#Other#$#ENSP00000422148#ENSG00000159692#ENST00000503594#Other#2-Hacid_dh_C$#ENSP00000426470#ENSG00000159692#ENST00000514210#Other#2-Hacid_dh, 2-Hacid_dh_C$#ENSP00000422730#ENSG00000159692#ENST00000504784#Other#$#ENSP00000420983#ENSG00000159692#ENST00000513420#Other#2-Hacid_dh$#ENSP00000425053#ENSG00000159692#ENST00000515399#Other#2-Hacid_dh FALSE 1909 ENSG00000175029 CTBP2 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR006139;IPR006140;IPR029753 1488 C-terminal binding protein 2 [Source:HGNC Symbol;Acc:HGNC:2495] None not tested not tested None None No No TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:11504872 No 5a, one of the source datasets predicts is as a TF Jussi Taipale Sam Lambert No None $##ENSG00000175029##Other# FALSE 1910 ENSG00000116761 CTH Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None None 1491 Cystathionine gamma-lyase None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Jussi Taipale Matt Weirauch No $#ENSG00000116761#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IEA - GO_REF:0000019 $##ENSG00000116761##Other# FALSE 1911 ENSG00000168036 CTNNB1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif Only known motifs are from Transfac or HocoMoco - origin is uncertain This is beta catenin - acts as co-factor with TCF/LEF IPR000225;IPR013284;IPR016024 1499 catenin beta 1 [Source:HGNC Symbol;Acc:HGNC:2514] None not tested not tested None None No Yes TF Gene_Transcription Factor Binding: tf co-factor binding_Co-activation_PMIDS:9671490;11983900 Yes 2a1, Lower confidence direct evidence Matt Weirauch Sam Lambert No $#ENSG00000168036#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019$#ENSG00000168036#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IMP - PMID:15905404 $#ENSP00000344456#ENSG00000168036#ENST00000349496#Other#Adaptin_N, Arm, Atx10homo_assoc, Cnd1, DUF3361, HE$#ENSP00000379486#ENSG00000168036#ENST00000396183#Other#Adaptin_N, Arm, Atx10homo_assoc, Cnd1, DUF3361, HE$#ENSP00000379488#ENSG00000168036#ENST00000396185#Other#Adaptin_N, Arm, Atx10homo_assoc, Cnd1, DUF3361, HE$#ENSP00000385604#ENSG00000168036#ENST00000405570#Other#Adaptin_N, Arm, Atx10homo_assoc, Cnd1, DUF3361, HE$#ENSP00000411226#ENSG00000168036#ENST00000453024#Other#Adaptin_N, Arm, Atx10homo_assoc, Cnd1, DUF3361, HE FALSE 1912 ENSG00000178585 CTNNBIP1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR009428 56998 catenin beta interacting protein 1 [Source:HGNC Symbol;Acc:HGNC:16913];Beta-catenin-interacting prot None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Sam Lambert Pratyush Das No $#ENSG00000178585#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#IMP - PMID:18977368 $#ENSP00000366474#ENSG00000178585#ENST00000377263#Other#ICAT$#ENSP00000383696#ENSG00000178585#ENST00000400904#Other#ICAT$#ENSP00000366468#ENSG00000178585#ENST00000377258#Other#ICAT$#ENSP00000366466#ENSG00000178585#ENST00000377256#Other#ICAT FALSE 1913 ENSG00000055130 CUL1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Component of the E3-ubiquitin ligase complex (PMID: 11961546) IPR001373;IPR016157;IPR016158;IPR016159;IPR019559; 8454 cullin 1 [Source:HGNC Symbol;Acc:HGNC:2551] None Full not tested None None x No No No 5a, one of the source datasets predicts is as a TF Matt Weirauch Arttu Jolma No None $#ENSP00000326804#ENSG00000055130#ENST00000325222#Other#Cullin, Cullin_Nedd8$#ENSP00000387160#ENSG00000055130#ENST00000409469#Other#Cullin, Cullin_Nedd8$#ENSP00000482123#ENSG00000055130#ENST00000617797#Other#Cullin, Cullin_Nedd8$#ENSP00000473318#ENSG00000055130#ENST00000602748#Other#Cullin, Cullin_Nedd8 FALSE 1914 ENSG00000108094 CUL2 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR001373;IPR016157;IPR016158;IPR016159;IPR019559; 8453 cullin 2 [Source:HGNC Symbol;Acc:HGNC:2552] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Pratyush Das Matt Weirauch No None $#ENSP00000363881#ENSG00000108094#ENST00000374749#Other#Cullin, Cullin_Nedd8, Rio2_N$#ENSP00000363883#ENSG00000108094#ENST00000374751#Other#Cullin, Cullin_Nedd8, Rio2_N$#ENSP00000414095#ENSG00000108094#ENST00000421317#Other#Cullin, Cullin_Nedd8, Rio2_N FALSE 1915 ENSG00000036257 CUL3 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR001373;IPR016157;IPR016158;IPR016159;IPR019559; 8452 cullin 3 [Source:HGNC Symbol;Acc:HGNC:2553] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Yimeng Yin Jussi Taipale No None $#ENSP00000264414#ENSG00000036257#ENST00000264414#Other#Cullin, Cullin_Nedd8$#ENSP00000387200#ENSG00000036257#ENST00000409096#Other#Cullin, Cullin_Nedd8$#ENSP00000386525#ENSG00000036257#ENST00000409777#Other#Cullin, Cullin_Nedd8$#ENSP00000343601#ENSG00000036257#ENST00000344951#Other#Cullin, Cullin_Nedd8 FALSE 1916 ENSG00000139842 CUL4A Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR001373;IPR016157;IPR016158;IPR016159;IPR019559; 8451 cullin 4A [Source:HGNC Symbol;Acc:HGNC:2554] 4A0K not tested not tested None Cullin does not contact DNA in the structure but it is contacted by DDB2 x No No No 3a, decent circumstantial evidence for its role as Sam Lambert Yimeng Yin No None $#ENSP00000322132#ENSG00000139842#ENST00000326335#Other#Cullin, Cullin_Nedd8$#ENSP00000364589#ENSG00000139842#ENST00000375440#Other#Cullin, Cullin_Nedd8$#ENSP00000364590#ENSG00000139842#ENST00000375441#Other#Cullin, Cullin_Nedd8$#ENSP00000481782#ENSG00000139842#ENST00000617546#Other#Cullin, Cullin_Nedd8$#ENSP00000480367#ENSG00000139842#ENST00000488558#Other#Cullin, SecA_SW FALSE 1917 ENSG00000158290 CUL4B Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Structure (PDB: 4A0L) shows that CUL4B is recruited to DNA and does not make direct contact with it IPR001373;IPR016157;IPR016158;IPR016159;IPR019559; 8450 cullin 4B [Source:HGNC Symbol;Acc:HGNC:2555] 4A0L not tested not tested None Cullin does not contact DNA in the structure but it is contacted by DDB2 x No No No 3a, decent circumstantial evidence for its role as Laura Campitelli Sam Lambert No None $#ENSP00000360373#ENSG00000158290#ENST00000371322#Other#Cullin, Cullin_Nedd8, SecA_SW$#ENSP00000384109#ENSG00000158290#ENST00000404115#Other#Cullin, Cullin_Nedd8, SecA_SW$#ENSP00000338919#ENSG00000158290#ENST00000336592#Other#Cullin, Cullin_Nedd8, SecA_SW$#ENSP00000360374#ENSG00000158290#ENST00000371323#Other#Cullin, SecA_SW FALSE 1918 ENSG00000166266 CUL5 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR001373;IPR016157;IPR016158;IPR016159;IPR019559; 8065 cullin 5 [Source:HGNC Symbol;Acc:HGNC:2556] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Sam Lambert Arttu Jolma No None $#ENSP00000376808#ENSG00000166266#ENST00000393094#Other#Cullin, Cullin_Nedd8$#ENSP00000431221#ENSG00000166266#ENST00000532782#Other#Cullin FALSE 1919 ENSG00000083799 CYLD Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000938;IPR001394;IPR018200;IPR028889 1540 CYLD lysine 63 deubiquitinase [Source:HGNC Symbol;Acc:HGNC:2584];Ubiquitin carboxyl-terminal hydrola None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Jussi Taipale Matt Weirauch No $#ENSG00000083799#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IDA - PMID:18313383 $#ENSP00000381574#ENSG00000083799#ENST00000398568#Other#CAP_GLY, CYLD_phos_site, UCH$#ENSP00000462134#ENSG00000083799#ENST00000566206#Other#CAP_GLY, CYLD_phos_site, UCH$#ENSP00000457576#ENSG00000083799#ENST00000569418#Other#CAP_GLY, CYLD_phos_site, UCH$#ENSP00000457108#ENSG00000083799#ENST00000569681#Other#$#ENSP00000463197#ENSG00000083799#ENST00000562884#Other#$#ENSP00000455535#ENSG00000083799#ENST00000564634#Other#$#ENSP00000458507#ENSG00000083799#ENST00000566024#Other# FALSE 1920 ENSG00000138061 CYP1B1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR001128;IPR002401;IPR017972 1545 cytochrome P450 family 1 subfamily B member 1 [Source:HGNC Symbol;Acc:HGNC:2597] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Sam Lambert Yimeng Yin No $#ENSG00000138061#GO:0032088#negative regulation of NF-kappaB transcription factor activity#ISS - GO_REF:0000024 $#ENSP00000478561#ENSG00000138061#ENST00000610745#Other#p450$#ENSP00000478839#ENSG00000138061#ENST00000490576#Other#p450$#ENSP00000479876#ENSG00000138061#ENST00000494864#Other#p450$#ENSP00000483678#ENSG00000138061#ENST00000614273#Other#p450 FALSE 1921 ENSG00000170891 CYTL1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None None 54360 Cytokine-like protein 1 None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Laura Campitelli Matt Weirauch No $#ENSG00000170891#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019 $##ENSG00000170891##Other# FALSE 1922 ENSG00000136848 DAB2IP Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000008;IPR001849;IPR001936;IPR008936;IPR021887;IPR023152 153090 DAB2 interacting protein [Source:HGNC Symbol;Acc:HGNC:17294];Disabled homolog 2-interacting protein None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Sam Lambert Jussi Taipale No $#ENSG00000136848#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IMP - PMID:20154697 $#ENSP00000310827#ENSG00000136848#ENST00000309989#Other#Bacillus_HBL, C2, DUF3498, RasGAP$#ENSP00000362887#ENSG00000136848#ENST00000373782#Other#Bacillus_HBL, C2, DUF3498, PH_2, RasGAP$#ENSP00000377872#ENSG00000136848#ENST00000394340#Other#C2, PH, PH_2$#ENSP00000409327#ENSG00000136848#ENST00000436835#Other#C2, PH, PH_2 FALSE 1923 ENSG00000276644 DACH1 Unknown Yes Likely to be sequence specific TF Monomer or homomultimer No motif Has a putative AT-hook Binds with consensus AAWANAAAWAAWT and AATACAATTAAAT as strongest target sequences based on EMSA and SELEX (PMID: 20351289). Protein contains a winged helix structural domain (PMID: 12057194) IPR003380;IPR009061 1602 Dachshund family transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:2663] None DBD and Full not tested None None a No No No 5a, one of the source datasets predicts is as a TF Arttu Jolma Pratyush Das No $#ENSG00000276644#GO:0001075#RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved#IBA - GO_REF:0000033$#ENSG00000276644#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:20956529 $#ENSP00000482245#ENSG00000276644#ENST00000613252#Other#Ski_Sno$#ENSP00000482493#ENSG00000276644#ENST00000611519#Other#Ski_Sno$#ENSP00000482797#ENSG00000276644#ENST00000619232#Other#Ski_Sno$#ENSP00000481551#ENSG00000276644#ENST00000620444#Other#Macoilin, Ski_Sno FALSE 1924 ENSG00000126733 DACH2 Unknown Yes Likely to be sequence specific TF Monomer or homomultimer No motif Has a putative AT-hook Related to DACH1, which can bind DNA based on EMSA and SELEX (PMID: 20351289). Yet, the fly ortholog has been extensively studied and cannot bind DNA. (PMID: 8431945; PMID: 7821215) IPR003380;IPR009061 117154 Dachshund family transcription factor 2 [Source:HGNC Symbol;Acc:HGNC:16814] None DBD and Full not tested None None a No No Yes 4a, two or more datasets predict it as a TF Matt Weirauch Yimeng Yin No $#ENSG00000126733#GO:0001075#RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved#IBA - GO_REF:0000033 $#ENSP00000362217#ENSG00000126733#ENST00000373125#Other#Ski_Sno$#ENSP00000362223#ENSG00000126733#ENST00000373131#Other#Ski_Sno$#ENSP00000422727#ENSG00000126733#ENST00000484479#Other#$#ENSP00000420896#ENSG00000126733#ENST00000508860#Other#$#ENSP00000421919#ENSG00000126733#ENST00000510272#Other# FALSE 1925 ENSG00000112977 DAP Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Protein functions in apoptotic signaling IPR024130 1611 death-associated protein [Source:HGNC Symbol;Acc:HGNC:2672] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Arttu Jolma Matt Weirauch No $#ENSG00000112977#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IMP - PMID:1087798 $#ENSP00000230895#ENSG00000112977#ENST00000230895#Other#DAP$#ENSP00000394163#ENSG00000112977#ENST00000432074#Other#DAP FALSE 1926 ENSG00000204209 DAXX Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Transcriptional co-repressor IPR005012 1616 death-domain associated protein [Source:HGNC Symbol;Acc:HGNC:2681] None not tested not tested None None No No TF Gene_Transcription Factor Binding: tf co-factor binding_Co-activation_PMIDS:11799127;12529400 No 5a, one of the source datasets predicts is as a TF Sam Lambert Yimeng Yin No None $##ENSG00000204209##Other# FALSE 1927 ENSG00000272886 DCP1A Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR010334 55802 DCP1 decapping enzyme homolog A (S. cerevisiae) None not tested not tested None None No No TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_TF PPI; Transactivation_PMIDS:11836524;11836524 No 5a, one of the source datasets predicts is as a TF Sam Lambert Yimeng Yin No None $##ENSG00000272886##Other# FALSE 1928 ENSG00000167986 DDB1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None DDB1 does not contact the DNA in the structure (PDB: 4E5Z) - contact is mediated by DDB2 IPR004871;IPR017986 1642 damage specific DNA binding protein 1 [Source:HGNC Symbol;Acc:HGNC:2717] 4E5Z not tested not tested None The structure is with damaged DNA and the DNA is contacted by DDB2 rather than DDB1 (Which binds to damaged DNA-presumably without base specificity) No No TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_Non-specific DNA_PMIDS:12034848;;9418871;12145536;12034848 No 3a, decent circumstantial evidence for its role as Yimeng Yin Arttu Jolma No None $##ENSG00000167986##Other# FALSE 1929 ENSG00000134574 DDB2 Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None DDB2 contacts the DNA in the (PDB: 4A0K) structure, albeit likely in a non sequence specific manner IPR001680;IPR017986;IPR019775 1643 damage specific DNA binding protein 2 [Source:HGNC Symbol;Acc:HGNC:2718] 4A0K not tested not tested None DDB2 contacts the DNA in the structure, presumably non sequence specifically No No Not a TF - Evidence that it is not a TF_Single stranded RNA/DNA binding_Other_PMIDS:12826282;9418871;9418871;12145536;12034848 No 3a, decent circumstantial evidence for its role as Pratyush Das Arttu Jolma No None $##ENSG00000134574##Other# FALSE 1930 ENSG00000181418 DDN Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif Has a putative AT-hook None IPR026500 23109 dendrin [Source:HGNC Symbol;Acc:HGNC:24458] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Yimeng Yin Pratyush Das No $#ENSG00000181418#GO:0000982#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IBA - GO_REF:0000033 $#ENSP00000390590#ENSG00000181418#ENST00000421952#Other#Dendrin FALSE 1931 ENSG00000162733 DDR2 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000421;IPR000719;IPR001245;IPR002011;IPR008266;IPR008979;IPR011009;IPR020635 4921 discoidin domain receptor tyrosine kinase 2 [Source:HGNC Symbol;Acc:HGNC:2731] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Sam Lambert Matt Weirauch No $#ENSG00000162733#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IMP - PMID:20564243 $#ENSP00000356898#ENSG00000162733#ENST00000367921#Other#F5_F8_type_C, Pkinase, Pkinase_Tyr$#ENSP00000356899#ENSG00000162733#ENST00000367922#Other#F5_F8_type_C, Pkinase, Pkinase_Tyr$#ENSP00000417030#ENSG00000162733#ENST00000458105#Other#$#ENSP00000396864#ENSG00000162733#ENST00000433757#Other#$#ENSP00000400309#ENSG00000162733#ENST00000446985#Other#F5_F8_type_C FALSE 1932 ENSG00000198171 DDRGK1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR019153 65992 DDRGK domain containing 1 [Source:HGNC Symbol;Acc:HGNC:16110] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Pratyush Das Arttu Jolma No $#ENSG00000198171#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IMP - PMID:23675531 $#ENSP00000346483#ENSG00000198171#ENST00000354488#Other#DDRGK$#ENSP00000369548#ENSG00000198171#ENST00000380201#Other#DDRGK FALSE 1933 ENSG00000215301 DDX3X Unknown No ssDNA/RNA binding Not a DNA binding protein No motif None Protein is a RNA-helicase that can however bind both RNA and DNA (PMID: 21589879). The interaction is presumably nonspecific and a portion of the DNA has to be single-stranded IPR000629;IPR001650;IPR011545;IPR014001;IPR014014;IPR027417 1654 DEAD-box helicase 3, X-linked [Source:HGNC Symbol;Acc:HGNC:2745] None not tested not tested None None No No TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:16818630 No 5a, one of the source datasets predicts is as a TF Pratyush Das Arttu Jolma No None $##ENSG00000215301##Other# FALSE 1934 ENSG00000108654 DDX5 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Transcriptional cofactor (PMID: 15298701) IPR000629;IPR001650;IPR011545;IPR012587;IPR014001;IPR014014;IPR027417 100616408 DEAD-box helicase 5 [Source:HGNC Symbol;Acc:HGNC:2746] None not tested not tested None None No No TF Gene_Transcription Factor Binding: tf co-factor binding_Co-activation; TF PPI_PMIDS:15464984;15657085 No 5a, one of the source datasets predicts is as a TF Laura Campitelli Jussi Taipale No None $##ENSG00000108654##Other# FALSE 1935 ENSG00000107201 DDX58 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR001650;IPR011545;IPR014001;IPR021673;IPR027417 23586 DEXD/H-box helicase 58 [Source:HGNC Symbol;Acc:HGNC:19102];Probable ATP-dependent RNA helicase DDX58 None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Pratyush Das Matt Weirauch No $#ENSG00000107201#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IC - PMID:17079289 $#ENSP00000369213#ENSG00000107201#ENST00000379883#Other#CARD_2, DEAD, Helicase_C, RIG-I_C-RD, ResIII$#ENSP00000369197#ENSG00000107201#ENST00000379868#Other#AAA_22, DEAD, Helicase_C, RIG-I_C-RD, ResIII FALSE 1936 ENSG00000124795 DEK Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None This protein binds to cruciform and superhelical DNA and induces positive supercoils into closed circular DNA, and is also involved in splice site selection during mRNA processing. (Entrez gene summary). So it must have some nonspecific DNA affinity. IPR003034;IPR014876 7913 DEK proto-oncogene [Source:HGNC Symbol;Acc:HGNC:2768] None not tested Yes None None x No No No 5a, one of the source datasets predicts is as a TF Jussi Taipale Yimeng Yin No None $#ENSP00000380414#ENSG00000124795#ENST00000397239#Other#DEK_C, DUF2052, SAP$#ENSP00000244776#ENSG00000124795#ENST00000244776#Other#DEK_C, DUF2052, SAP$#ENSP00000423427#ENSG00000124795#ENST00000507591#Other#DEK_C$#ENSP00000423553#ENSG00000124795#ENST00000515742#Other# FALSE 1937 ENSG00000024526 DEPDC1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Interacts with transcriptional corepressor ZNF224 (PMID: 20587513) IPR000198;IPR000591;IPR008936; 55635 DEP domain containing 1 [Source:HGNC Symbol;Acc:HGNC:22949] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Laura Campitelli Tim Hughes No None $#ENSP00000360005#ENSG00000024526#ENST00000370966#Other#DEP, RhoGAP$#ENSP00000412292#ENSG00000024526#ENST00000456315#Other#DEP, RhoGAP$#ENSP00000431477#ENSG00000024526#ENST00000525124#Other# FALSE 1938 ENSG00000035499 DEPDC1B Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Protein does not have known DBDs and has been shown to function as an inhibitor of a RhoA-based signaling complex (PMID: 25458010) IPR000198;IPR000591;IPR008936; 55789 DEP domain containing 1B [Source:HGNC Symbol;Acc:HGNC:24902] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Arttu Jolma Pratyush Das No None $#ENSP00000265036#ENSG00000035499#ENST00000265036#Other#DEP, RhoGAP$#ENSP00000389101#ENSG00000035499#ENST00000453022#Other#DEP, RhoGAP FALSE 1939 ENSG00000166153 DEPDC4 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000591; 120863 DEP domain containing 4 [Source:HGNC Symbol;Acc:HGNC:22952] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Jussi Taipale Pratyush Das No None $#ENSP00000396234#ENSG00000166153#ENST00000416321#Other#DEP$#ENSP00000448338#ENSG00000166153#ENST00000549249#Other#DEP$#ENSP00000448385#ENSG00000166153#ENST00000550587#Other#DEP$#ENSP00000449590#ENSG00000166153#ENST00000551642#Other#DEP$#ENSP00000448728#ENSG00000166153#ENST00000548313#Other# FALSE 1940 ENSG00000100150 DEPDC5 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000591;IPR027244 9681 DEP domain containing 5 [Source:HGNC Symbol;Acc:HGNC:18423] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Matt Weirauch Yimeng Yin No None $#ENSP00000371546#ENSG00000100150#ENST00000382112#Other#DEP, IML1$#ENSP00000383101#ENSG00000100150#ENST00000400242#Other#IML1$#ENSP00000383105#ENSG00000100150#ENST00000400246#Other#DEP, IML1$#ENSP00000383107#ENSG00000100150#ENST00000400248#Other#DEP, IML1$#ENSP00000410544#ENSG00000100150#ENST00000433147#Other#DEP$#ENSP00000440210#ENSG00000100150#ENST00000535622#Other#DEP, IML1 FALSE 1941 ENSG00000121690 DEPDC7 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Included only because Vasquerizas 2009 includes it with an x. No DBD and no other data to support being a TF. IPR000591; 91614 DEP domain containing 7 [Source:HGNC Symbol;Acc:HGNC:29899] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Sam Lambert Tim Hughes No None $#ENSP00000241051#ENSG00000121690#ENST00000241051#Other#DEP$#ENSP00000308971#ENSG00000121690#ENST00000311388#Other#DEP FALSE 1942 ENSG00000155792 DEPTOR Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000591;IPR001478 64798 DEP domain containing MTOR-interacting protein [Source:HGNC Symbol;Acc:HGNC:22953] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Sam Lambert Jussi Taipale No None $#ENSP00000286234#ENSG00000155792#ENST00000286234#Other#DEP, PDZ_2$#ENSP00000430457#ENSG00000155792#ENST00000523492#Other#DEP, PDZ_2 FALSE 1943 ENSG00000134815 DHX34 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR001650;IPR007502;IPR011545;IPR011709;IPR014001;IPR027417 9704 DEAH-box helicase 34 [Source:HGNC Symbol;Acc:HGNC:16719] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Sam Lambert Pratyush Das No None $#ENSP00000331907#ENSG00000134815#ENST00000328771#Other#AAA_22, DEAD, HA2, Helicase_C, OB_NTP_bind FALSE 1944 ENSG00000174953 DHX36 Unknown No ssDNA/RNA binding Not a DNA binding protein No motif None Binds single stranded DNA in the structure (PDB: 2N21) None None DEAH-box helicase 36 2N21 not tested not tested None Binds single stranded DNA in the structure (PDB: 2N21) No No No No New proteins added based on PDB entry Arttu Jolma Sam Lambert No None None FALSE 1945 ENSG00000204624 DISP3 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000731;IPR003392;IPR004869; 57540 dispatched RND transporter family member 3 [Source:HGNC Symbol;Acc:HGNC:29251] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Sam Lambert Pratyush Das No None $#ENSP00000294484#ENSG00000204624#ENST00000294484#Other#MMPL, Patched, Sterol-sensing$#ENSP00000303400#ENSG00000204624#ENST00000304391#Other# FALSE 1946 ENSG00000178028 DMAP1 Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None Component of the NuA4 histone acetyltransferase (HAT) complex, which is involved in transcriptional activation of select genes, principally by acetylation of nucleosomal histones H4 and H2A (PMID: 14966270). (PMID: 20864525) shows DNA binding is sequence independent. IPR008468; 55929 DNA methyltransferase 1 associated protein 1 [Source:HGNC Symbol;Acc:HGNC:18291] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Laura Campitelli Pratyush Das Yes None $#ENSP00000312697#ENSG00000178028#ENST00000315913#Other#DMAP1, SANT_DAMP1_like$#ENSP00000354697#ENSG00000178028#ENST00000361745#Other#DMAP1, SANT_DAMP1_like$#ENSP00000361363#ENSG00000178028#ENST00000372289#Other#DMAP1, SANT_DAMP1_like$#ENSP00000400269#ENSG00000178028#ENST00000436069#Other#$#ENSP00000402494#ENSG00000178028#ENST00000437511#Other#SANT_DAMP1_like$#ENSP00000401099#ENSG00000178028#ENST00000440641#Other#SANT_DAMP1_like$#ENSP00000409200#ENSG00000178028#ENST00000446292#Other#DMAP1, SANT_DAMP1_like FALSE 1947 ENSG00000100206 DMC1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR003593;IPR010995;IPR011940;IPR013632;IPR016467;IPR020587;IPR020588;IPR027417 11144 DNA meiotic recombinase 1 [Source:HGNC Symbol;Acc:HGNC:2927] None Full not tested None None x No No No 5a, one of the source datasets predicts is as a TF Jussi Taipale Matt Weirauch No None $#ENSP00000216024#ENSG00000100206#ENST00000216024#Other#AAA_25, ATPase, DUF128, HHH_5, Rad51, RecA$#ENSP00000477737#ENSG00000100206#ENST00000616615#Other#DUF128, HHH_5, Rad51, RecA$#ENSP00000412703#ENSG00000100206#ENST00000428462#Other#ATPase, DUF128, HHH_5, Rad51, RecA$#ENSP00000391385#ENSG00000100206#ENST00000439567#Other#ATPase, DUF128, HHH_5, Rad51, RecA FALSE 1948 ENSG00000269502 DMRTC1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None This particular DM protein lacks the DM DBD (PMID: 16488114) IPR031577;IPR026607 63947 DMRT like family C1 [Source:HGNC Symbol;Acc:HGNC:13910];Doublesex- and mab-3-related transcription f None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Arttu Jolma Pratyush Das Yes $#ENSG00000269502#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000469615#ENSG00000269502#ENST00000596389#Other#DMRT-like$#ENSP00000471224#ENSG00000269502#ENST00000595412#Other#DMRT-like$#ENSP00000484718#ENSG00000269502#ENST00000615063#Other#DMRT-like FALSE 1949 ENSG00000138346 DNA2 Unknown No ssDNA/RNA binding Not a DNA binding protein No motif None Helicase involved in genome integrity. Binds single stranded DNA in the structure (PDB: 5EAN) None None DNA replication helicase/nuclease 2 5EAN not tested not tested None Helicase involved in genome integrity. Binds single stranded DNA in the structure (PDB: 5EAN) No No No No New proteins added based on PDB entry Arttu Jolma Sam Lambert No None None FALSE 1950 ENSG00000103423 DNAJA3 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Protein functions in a chaperone complex IPR001305;IPR001623;IPR002939;IPR008971;IPR018253 None DnaJ heat shock protein family (Hsp40) member A3 [Source:HGNC Symbol;Acc:HGNC:11808];DnaJ homolog subfamily A member 3, mitochondrial None not tested not tested None Protein functions in a chaperone complex No No No Yes 5a, one of the source datasets predicts is as a TF Arttu Jolma Pratyush Das No None None FALSE 1951 ENSG00000168724 DNAJC21 Unknown No ssDNA/RNA binding Not a DNA binding protein No motif None Contains a single Matrin-type or U1-type C2H2 domain, which typically binds dsRNA. Its a known heat shock protein that may also be involved in rRNA processing. IPR001623;IPR003604;IPR007087;IPR015880;IPR018253;IPR022755 134218 DnaJ heat shock protein family (Hsp40) member C21 [Source:HGNC Symbol;Acc:HGNC:27030] None not tested not tested None None c No No No 1a1, Direct HQ evidence Jussi Taipale Pratyush Das No None $#ENSP00000343728#ENSG00000168724#ENST00000342382#Other#DnaJ, zf-C2H2_2, zf-C2H2_4, zf-C2H2_6, zf-C2H2_jaz$#ENSP00000371451#ENSG00000168724#ENST00000382021#Other#DnaJ, zf-C2H2_2, zf-C2H2_4, zf-C2H2_6, zf-C2H2_jaz FALSE 1952 ENSG00000119772 DNMT3A Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None DNMT3A and DNMT3B are de novo methyltransferases that are activated by enzymatically inactive paralog DNMT3L. Besides the C-terminal catalytic core, the PWWP domain of 3A and 3B can also bind to DNA. Presumably there is no sequence specificity and instead the de novo methylation complexes are recruited by histone modifications on the N-terminal tail of H3. Reviewed in (PMID: 27826835). None None DNA methyltransferase 3 alpha None not tested not tested None None No No No No Protein added after initial stage, no initial assesment Arttu Jolma Sam Lambert Yes None None FALSE 1953 ENSG00000088305 DNMT3B Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None DNMT3A and DNMT3B are de novo methyltransferases that are activated by enzymatically inactive paralog DNMT3L. Besides the C-terminal catalytic core, the PWWP domain of 3A and 3B can also bind to DNA. Presumably there is no sequence specificity and instead the de novo methylation complexes are recruited by histone modifications on the N-terminal tail of H3. Reviewed in (PMID: 27826835). None None DNA methyltransferase 3 beta None not tested not tested None None No No No No Protein added after initial stage, no initial assesment Arttu Jolma Sam Lambert Yes None None FALSE 1954 ENSG00000142182 DNMT3L Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None DNMT3A and DNMT3B are de novo methyltransferases that are activated by enzymatically inactive paralog DNMT3L. Besides the C-terminal catalytic core, the PWWP domain of 3A and 3B can also bind to DNA. Presumably there is no sequence specificity and instead the de novo methylation complexes are recruited by histone modifications on the N-terminal tail of H3. Reviewed in (PMID: 27826835). None None DNA methyltransferase 3 like None not tested not tested None None No No No No Protein added after initial stage, no initial assesment Arttu Jolma Sam Lambert Yes None None FALSE 1955 ENSG00000107447 DNTT Unknown No ssDNA/RNA binding Not a DNA binding protein No motif None Binds single stranded DNA in the structure (PDB: 4I27) None None DNA nucleotidylexotransferase 4I27 not tested not tested None Binds single stranded DNA in the structure (PDB: 4I27) No No No No New proteins added based on PDB entry Arttu Jolma Sam Lambert No None None FALSE 1956 ENSG00000133884 DPF2 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None No evidence for DNA-binding activity - possible role in transcriptional regulation complex (PMID: 16785614) IPR001965;IPR007087;IPR011011;IPR015880;IPR019787;IPR025750 5977 double PHD fingers 2 [Source:HGNC Symbol;Acc:HGNC:9964] None DBD and Full not tested None None a No Indeterminate - There is no evidence for or against this genes role as a TF__Other_PMIDS:7961935;7961935;10781338 No 4a, two or more datasets predict it as a TF Tim Hughes Laura Campitelli No None $#ENSP00000436901#ENSG00000133884#ENST00000528416#Other#PHD, PHD_4, Requiem_N$#ENSP00000399714#ENSG00000133884#ENST00000415073#Other#PHD, Requiem_N$#ENSP00000435887#ENSG00000133884#ENST00000531989#Other#PHD$#ENSP00000252268#ENSG00000133884#ENST00000252268#Other#PHD, PHD_4, Requiem_N FALSE 1957 ENSG00000117505 DR1 Unknown Yes Likely to be sequence specific TF Obligate heteromer No motif None Binds DNA as a heterotrimeric complex of TBP, DR1, and DRAP1 (PDB: 1JFI) IPR003958;IPR009072 1810 down-regulator of transcription 1 [Source:HGNC Symbol;Acc:HGNC:3017] 1JFI DBD and Full not tested Obligate heteromultimer, with at least DR1 and als Structure has DRAP1, DR1 and TBP b No No No 3a, decent circumstantial evidence for its role as Arttu Jolma Laura Campitelli No None $#ENSP00000359295#ENSG00000117505#ENST00000370272#Other#CBFD_NFYB_HMF, CENP-W, Histone$#ENSP00000359290#ENSG00000117505#ENST00000370267#Other#CBFD_NFYB_HMF, CENP-W, Histone FALSE 1958 ENSG00000175550 DRAP1 Unknown Yes Likely to be sequence specific TF Obligate heteromer No motif None Based on structure (PDB: 1JFI), it forms the obligate heterodimer DR1-DRAP1 that furthermore contacts TBP. Only makes contact with the minor groove in a histone-like interaction, which is probably non-specific (PMID: 11461703) IPR003958;IPR009072 10589 DR1 associated protein 1 [Source:HGNC Symbol;Acc:HGNC:3019] 1JFI DBD and Full not tested Obligate heteromultimer, with at least DR1 and als Structure has DRAP1, DR1 and TBP b No TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:12471260 Yes 3a, decent circumstantial evidence for its role as Pratyush Das Yimeng Yin No $#ENSG00000175550#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:8608938 $#ENSP00000307850#ENSG00000175550#ENST00000312515#Other#CBFD_NFYB_HMF, FXMRP1_C_core, Histone$#ENSP00000432445#ENSG00000175550#ENST00000532933#Other#CBFD_NFYB_HMF, FXMRP1_C_core FALSE 1959 ENSG00000096696 DSP Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR001101;IPR018159 1832 desmoplakin [Source:HGNC Symbol;Acc:HGNC:3052] None Full not tested None None x No No No 5a, one of the source datasets predicts is as a TF Sam Lambert Yimeng Yin No None $#ENSP00000369129#ENSG00000096696#ENST00000379802#Other#ERM, Plectin$#ENSP00000396591#ENSG00000096696#ENST00000418664#Other#ERM, Plectin FALSE 1960 ENSG00000135144 DTX1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None This protein is an E3 ligase that operates in the Notch pathway IPR001841;IPR004170;IPR018123 1840 deltex 1 [Source:HGNC Symbol;Acc:HGNC:3060] None not tested not tested None None No No TF Gene_Transcription Factor Binding: tf co-factor binding_Transactivation_PMIDS:11226752;11564735 No 5a, one of the source datasets predicts is as a TF Yimeng Yin Sam Lambert No None $##ENSG00000135144##Other# FALSE 1961 ENSG00000081721 DUSP12 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000340;IPR000387;IPR007087;IPR016278;IPR020422;IPR029021 11266 dual specificity phosphatase 12 [Source:HGNC Symbol;Acc:HGNC:3067] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Pratyush Das Laura Campitelli No None $#ENSP00000356920#ENSG00000081721#ENST00000367943#Other#DSPc, Init_tRNA_PT FALSE 1962 ENSG00000107404 DVL1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000591;IPR001158;IPR001478;IPR003351;IPR008339;IPR024580;IPR029071; 102466740 dishevelled segment polarity protein 1 [Source:HGNC Symbol;Acc:HGNC:3084] None not tested not tested None None x No Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0 No 4a, two or more datasets predict it as a TF Sam Lambert Matt Weirauch No None $#ENSP00000368169#ENSG00000107404#ENST00000378891#Other#DEP, DIX, Dishevelled, Dsh_C, PDZ, PDZ_2$#ENSP00000480077#ENSG00000107404#ENST00000610709#Other#DIX, Dishevelled, Dsh_C FALSE 1963 ENSG00000004975 DVL2 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None DVL2 does not have any known DBDs; or experimental evidence to suggest it is a TF. IPR000591;IPR001158;IPR001478;IPR003351;IPR008339;IPR008341;IPR024580;IPR029071 1856 dishevelled segment polarity protein 2 [Source:HGNC Symbol;Acc:HGNC:3086] None not tested not tested None None x No No Yes 4a, two or more datasets predict it as a TF Sam Lambert Matt Weirauch No $#ENSG00000004975#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:17593335 $#ENSP00000005340#ENSG00000004975#ENST00000005340#Other#DEP, DIX, Dishevelled, Dsh_C, PDZ, PDZ_2$#ENSP00000459797#ENSG00000004975#ENST00000575458#Other#DEP, DIX, Dishevelled, Dsh_C, PDZ, PDZ_2$#ENSP00000458209#ENSG00000004975#ENST00000574143#Other#DIX, Dishevelled, PDZ, PDZ_2$#ENSP00000458465#ENSG00000004975#ENST00000575086#Other#DEP, Dsh_C FALSE 1964 ENSG00000161202 DVL3 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000591;IPR001158;IPR001478;IPR003351;IPR008339;IPR008342;IPR024580;IPR029071 1857 dishevelled segment polarity protein 3 [Source:HGNC Symbol;Acc:HGNC:3087] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Sam Lambert Arttu Jolma No None $#ENSP00000316054#ENSG00000161202#ENST00000313143#Other#DEP, DIX, Dishevelled, Dsh_C, PDZ$#ENSP00000405885#ENSG00000161202#ENST00000431765#Other#DEP, DIX, Dishevelled, Dsh_C, PDZ$#ENSP00000393849#ENSG00000161202#ENST00000423300#Other#Dishevelled, PDZ, PDZ_2, Shufflon_N FALSE 1965 ENSG00000158163 DZIP1L Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Contains a weak ProSite match for a single C2H2 ZF (Uniprot) but not a Pfam match. No experimental evidence for DNA-binding exists IPR007087; 199221 DAZ interacting zinc finger protein 1 like [Source:HGNC Symbol;Acc:HGNC:26551] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Arttu Jolma Sam Lambert No None $#ENSP00000332148#ENSG00000158163#ENST00000327532#Other#Dzip-like_N$#ENSP00000420600#ENSG00000158163#ENST00000467030#Other#Dzip-like_N$#ENSP00000419486#ENSG00000158163#ENST00000469243#Other#Dzip-like_N$#ENSP00000417228#ENSG00000158163#ENST00000486487#Other#$#ENSP00000420051#ENSG00000158163#ENST00000492010#Other# FALSE 1966 ENSG00000145088 EAF2 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None No convincing evidence that this protein binds DNA with any sequence specificity, or that this activity is required for its function. Thus at best the current evidence is that it is a cofactor of some sort cofactor (PMID: 12446457) IPR019194 55840 ELL associated factor 2 [Source:HGNC Symbol;Acc:HGNC:23115] None not tested not tested None None No No TF Gene Candidate_Transcription Factor Binding: tf co-factor binding; DNA-Binding: sequence-specific_TF PPI; Transactivation_PMIDS:12446457;16114057 Yes 4a, two or more datasets predict it as a TF Sam Lambert Matt Weirauch No $#ENSG00000145088#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IDA - PMID:16114057 $#ENSP00000273668#ENSG00000145088#ENST00000273668#Other#EAF$#ENSP00000410708#ENSG00000145088#ENST00000451944#Other#EAF FALSE 1967 ENSG00000158813 EDA Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Cell surface protein that can be cleaved into a secreted one IPR006052;IPR008160;IPR008983 1896 ectodysplasin A [Source:HGNC Symbol;Acc:HGNC:3157] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Arttu Jolma Matt Weirauch No $#ENSG00000158813#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IDA - PMID:11039935 $#ENSP00000363680#ENSG00000158813#ENST00000374552#Other#Collagen, TNF$#ENSP00000363681#ENSG00000158813#ENST00000374553#Other#Collagen, TNF$#ENSP00000432585#ENSG00000158813#ENST00000524573#Other#Collagen, TNF$#ENSP00000434195#ENSG00000158813#ENST00000525810#Other#$#ENSP00000434861#ENSG00000158813#ENST00000527388#Other#$#ENSP00000340611#ENSG00000158813#ENST00000338901#Other# FALSE 1968 ENSG00000131080 EDA2R Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Included only because GO says positive regulation of sequence-specific DNA binding transcription factor activity. Not DNA binding. IPR001368;IPR022319 60401 ectodysplasin A2 receptor [Source:HGNC Symbol;Acc:HGNC:17756] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Tim Hughes Matt Weirauch No $#ENSG00000131080#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IDA - PMID:11039935 $#ENSP00000253392#ENSG00000131080#ENST00000253392#Other#TNFR_c6$#ENSP00000363851#ENSG00000131080#ENST00000374719#Other#TNFR_c6$#ENSP00000379365#ENSG00000131080#ENST00000396050#Other#TNFR_c6$#ENSP00000415242#ENSG00000131080#ENST00000451436#Other#TNFR_c6 FALSE 1969 ENSG00000107223 EDF1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Known co-factor that binds DNA indirectly through interactions with TFs (PMID:12040021) IPR001387;IPR010982;IPR013729; 8721 endothelial differentiation related factor 1 [Source:HGNC Symbol;Acc:HGNC:3164] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Sam Lambert Jussi Taipale No $#ENSG00000107223#GO:0003700#sequence-specific DNA binding transcription factor activity#IMP - PMID:12040021 $#ENSP00000224073#ENSG00000107223#ENST00000224073#Other#HTH_3, HTH_31, MBF1$#ENSP00000360711#ENSG00000107223#ENST00000371648#Other#HTH_3, HTH_31, MBF1$#ENSP00000360712#ENSG00000107223#ENST00000371649#Other#HTH_3, HTH_31, MBF1 FALSE 1970 ENSG00000078401 EDN1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Protein that is processed into a secreted signaling peptide IPR001928;IPR019764;IPR020475 1906 endothelin 1 [Source:HGNC Symbol;Acc:HGNC:3176] None not tested Yes None None No No No Yes 5a, one of the source datasets predicts is as a TF Arttu Jolma Laura Campitelli No $#ENSG00000078401#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:24117217 $#ENSP00000368683#ENSG00000078401#ENST00000379375#Other#Endothelin FALSE 1971 ENSG00000074266 EED Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Affects transcription by histone modification (PMID: 16357870) IPR001680;IPR017986;IPR019775 102465452 embryonic ectoderm development [Source:HGNC Symbol;Acc:HGNC:3188] None not tested not tested None None No No TF Gene Candidate__Transactivation_PMIDS:9234727 No 5a, one of the source datasets predicts is as a TF Yimeng Yin Laura Campitelli No None $##ENSG00000074266##Other# FALSE 1972 ENSG00000135766 EGLN1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR002893;IPR005123;IPR006620 54583 egl-9 family hypoxia inducible factor 1 [Source:HGNC Symbol;Acc:HGNC:1232] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Jussi Taipale Matt Weirauch No $#ENSG00000135766#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:16956324 $#ENSP00000355601#ENSG00000135766#ENST00000366641#Other#2OG-FeII_Oxy_3, 2OG-FeII_Oxy_4, zf-MYND FALSE 1973 ENSG00000255302 EID1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None None 23741 EP300 interacting inhibitor of differentiation 1 [Source:HGNC Symbol;Acc:HGNC:1191] None not tested not tested None None No No TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_Co-activation_PMIDS:11964378 No 5a, one of the source datasets predicts is as a TF Jussi Taipale Pratyush Das No None $##ENSG00000255302##Other# FALSE 1974 ENSG00000176396 EID2 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Associates with histone deacetylases (PMID: 12586827) None 163126 EP300 interacting inhibitor of differentiation 2 [Source:HGNC Symbol;Acc:HGNC:28292] None not tested not tested None None No No TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:14585496;14612439 No 5a, one of the source datasets predicts is as a TF Pratyush Das Jussi Taipale No None $##ENSG00000176396##Other# FALSE 1975 ENSG00000055332 EIF2AK2 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000719;IPR002290;IPR008271;IPR011009;IPR014720;IPR017441 5610 eukaryotic translation initiation factor 2 alpha kinase 2 [Source:HGNC Symbol;Acc:HGNC:9437];Interfe None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Yimeng Yin Sam Lambert No $#ENSG00000055332#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IDA - PMID:15121867 $#ENSP00000385014#ENSG00000055332#ENST00000405334#Other#Kinase-like, Pkinase, Pkinase_Tyr, dsrm$#ENSP00000233057#ENSG00000055332#ENST00000233057#Other#Kinase-like, Pkinase, Pkinase_Tyr, dsrm$#ENSP00000374663#ENSG00000055332#ENST00000390013#Other#DND1_DSRM, dsrm FALSE 1976 ENSG00000128829 EIF2AK4 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000719;IPR002290;IPR006575;IPR008271;IPR011009;IPR016135;IPR016255;IPR017441;IPR024435 440275 eukaryotic translation initiation factor 2 alpha kinase 4 [Source:HGNC Symbol;Acc:HGNC:19687];eIF-2- None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Pratyush Das Yimeng Yin No $#ENSG00000128829#GO:0032792#negative regulation of CREB transcription factor activity#ISS - GO_REF:0000024 $#ENSP00000453148#ENSG00000128829#ENST00000559624#Other#Pkinase, Pkinase_Tyr, RWD$#ENSP00000263791#ENSG00000128829#ENST00000263791#Other#HGTP_anticodon2, Kdo, Kinase-like, Pkinase, Pkinas$#ENSP00000454210#ENSG00000128829#ENST00000558823#Other#DUF3734$#ENSP00000453968#ENSG00000128829#ENST00000560648#Other#RWD FALSE 1977 ENSG00000184110 EIF3C Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000717;IPR008905 728689 eukaryotic translation initiation factor 3 subunit C [Source:HGNC Symbol;Acc:HGNC:3279] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Sam Lambert Pratyush Das No None $#ENSP00000332604#ENSG00000184110#ENST00000331666#Other#PCI, eIF-3c_N$#ENSP00000378953#ENSG00000184110#ENST00000395587#Other#PCI, eIF-3c_N$#ENSP00000457963#ENSG00000184110#ENST00000566501#Other#PCI, eIF-3c_N$#ENSP00000457418#ENSG00000184110#ENST00000566866#Other#PCI, eIF-3c_N$#ENSP00000456416#ENSG00000184110#ENST00000564243#Other#PCI, eIF-3c_N$#ENSP00000455278#ENSG00000184110#ENST00000569690#Other#eIF-3c_N FALSE 1978 ENSG00000205609 EIF3CL Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000717;IPR008905 728689 eukaryotic translation initiation factor 3 subunit C-like [Source:HGNC Symbol;Acc:HGNC:26347] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Sam Lambert Laura Campitelli No None $#ENSP00000370258#ENSG00000205609#ENST00000380876#Other#PCI, eIF-3c_N$#ENSP00000381917#ENSG00000205609#ENST00000398944#Other#PCI, eIF-3c_N FALSE 1979 ENSG00000178982 EIF3K Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR005062;IPR016024 27335 eukaryotic translation initiation factor 3 subunit K [Source:HGNC Symbol;Acc:HGNC:24656] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Sam Lambert Jussi Taipale No None $#ENSP00000248342#ENSG00000178982#ENST00000248342#Other#CSN8_PSD8_EIF3K$#ENSP00000479334#ENSG00000178982#ENST00000614624#Other#CSN8_PSD8_EIF3K$#ENSP00000440999#ENSG00000178982#ENST00000538434#Other#CSN8_PSD8_EIF3K$#ENSP00000438145#ENSG00000178982#ENST00000545173#Other#CSN8_PSD8_EIF3K$#ENSP00000468231#ENSG00000178982#ENST00000592558#Other#CSN8_PSD8_EIF3K$#ENSP00000465460#ENSG00000178982#ENST00000593149#Other#CSN8_PSD8_EIF3K$#ENSP00000468525#ENSG00000178982#ENST00000588934#Other#CSN8_PSD8_EIF3K$#ENSP00000467895#ENSG00000178982#ENST00000591409#Other#CSN8_PSD8_EIF3K FALSE 1980 ENSG00000154920 EME1 Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None Binds DNA in the crystal structure (PDB: 4P0P) in a heterodimeric complex with MUS81. None None essential meiotic structure-specific endonuclease 1 4P0P not tested not tested None Binds DNA in the crystal structure (PDB: 4P0P) in a heterodimeric complex with MUS81. No No No No New proteins added based on PDB entry Arttu Jolma Sam Lambert No None None FALSE 1981 ENSG00000074800 ENO1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif Only known motifs are from Transfac or HocoMoco - origin is uncertain Enolase - DNA binding not shown to be direct IPR000941;IPR020809;IPR020810;IPR020811;IPR029017;IPR029065 2023 enolase 1 [Source:HGNC Symbol;Acc:HGNC:3350] None not tested not tested None None No Yes No No 2a1, Lower confidence direct evidence Yimeng Yin Sam Lambert No None $#ENSP00000234590#ENSG00000074800#ENST00000234590#Other#Enolase_C, Enolase_N, MAAL_C, MR_MLE_C$#ENSP00000468392#ENSG00000074800#ENST00000489867#Other#Enolase_N$#ENSP00000466406#ENSG00000074800#ENST00000497492#Other#Enolase_C, Enolase_N FALSE 1982 ENSG00000100393 EP300 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif Only known motifs are from Transfac or HocoMoco - origin is uncertain p300 is an archetype cofactor. It has many motifs, presumably because many TFs recruit it. Does not contact DNA in the structure (PDB: 3P57) IPR000197;IPR000433;IPR001487;IPR003101;IPR009110;IPR010303;IPR013178;IPR014744;IPR018359 100302237 E1A binding protein p300 [Source:HGNC Symbol;Acc:HGNC:3373];Histone acetyltransferase p300 3P57 not tested not tested None EP300 does not contact the DNA in the structure but contacts MEF2A that contacts DNA No Yes TF Gene_Transcription Factor Binding: tf co-factor binding_Co-activation_PMIDS:11481322;12586840 Yes 2a1, Lower confidence direct evidence Matt Weirauch Pratyush Das No $#ENSG00000100393#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IEA - GO_REF:0000019$#ENSG00000100393#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:10518217 $#ENSP00000263253#ENSG00000100393#ENST00000263253#Other#Bromodomain, Creb_binding, DUF902, HAT_KAT11, KIX,$#ENSP00000489397#ENSG00000100393#ENST00000634690#Other#KIX, KIX_2$#ENSP00000488981#ENSG00000100393#ENST00000634728#Other#KIX FALSE 1983 ENSG00000183495 EP400 Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif Has a putative AT-hook Protein is a nucleosome remodeling complex component with a role in depositing the H3.3 variant histone into promoter and enhancer regions (PMID: 26669263). Its MYB-like and helicase domains are likely non-specific DNA binding domains IPR000330;IPR001650;IPR013999;IPR014001;IPR014012;IPR017877;IPR027417; 57634 E1A binding protein p400 None not tested not tested None None x Yes No No 4a, two or more datasets predict it as a TF Sam Lambert Arttu Jolma No None $#ENSP00000331737#ENSG00000183495#ENST00000332482#Other#EP400_N, HSA$#ENSP00000333602#ENSG00000183495#ENST00000333577#Other#EP400_N, HSA$#ENSP00000374213#ENSG00000183495#ENST00000389562#Other#EP400_N, HSA, Helicase_C, SNF2_N$#ENSP00000330620#ENSG00000183495#ENST00000330386#Other# FALSE 1984 ENSG00000145242 EPHA5 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000719;IPR001090;IPR001245;IPR001426;IPR001660;IPR003961;IPR008266;IPR008979;IPR009030;IPR011009;IPR013761; 2044 EPH receptor A5 [Source:HGNC Symbol;Acc:HGNC:3389];Ephrin type-A receptor 5 None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Laura Campitelli Matt Weirauch No $#ENSG00000145242#GO:0032793#positive regulation of CREB transcription factor activity#ISS - GO_REF:0000024 $#ENSP00000273854#ENSG00000145242#ENST00000273854#Other#EphA2_TM, Ephrin_lbd, Ephrin_rec_like, HNH_5, Pkin$#ENSP00000346899#ENSG00000145242#ENST00000354839#Other#EphA2_TM, Ephrin_lbd, Ephrin_rec_like, HNH_5, Pkin$#ENSP00000427638#ENSG00000145242#ENST00000511294#Other#EphA2_TM, Ephrin_lbd, Ephrin_rec_like, HNH_5, Pkin$#ENSP00000478537#ENSG00000145242#ENST00000613740#Other#EphA2_TM, Ephrin_lbd, Ephrin_rec_like, HNH_5, Pkin$#ENSP00000480763#ENSG00000145242#ENST00000622150#Other#EphA2_TM, Ephrin_lbd, Ephrin_rec_like, HNH_5, Pkin FALSE 1985 ENSG00000178567 EPM2AIP1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Protein that binds and regulates glycogen synthase allosterically (PMID: 24142699) IPR026630 9852 EPM2A interacting protein 1 [Source:HGNC Symbol;Acc:HGNC:19735] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Pratyush Das Arttu Jolma No $#ENSG00000178567#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000485489#ENSG00000178567#ENST00000623924#Other#$#ENSP00000485091#ENSG00000178567#ENST00000624586#Other#$#ENSP00000406027#ENSG00000178567#ENST00000322716#Other# FALSE 1986 ENSG00000112851 ERBIN Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR001478;IPR001611;IPR003591;IPR025875 55914 erbb2 interacting protein [Source:HGNC Symbol;Acc:HGNC:15842] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Yimeng Yin Matt Weirauch No $#ENSG00000112851#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IMP - PMID:16203728 $#ENSP00000284037#ENSG00000112851#ENST00000284037#Other#LRR_4, LRR_5, LRR_8, PDZ, PDZ_2$#ENSP00000370330#ENSG00000112851#ENST00000380943#Other#LRR_4, LRR_5, LRR_8, PDZ, PDZ_2$#ENSP00000426632#ENSG00000112851#ENST00000506030#Other#LRR_4, LRR_5, LRR_8, PDZ, PDZ_2$#ENSP00000370325#ENSG00000112851#ENST00000380938#Other#LRR_4, LRR_5, LRR_8$#ENSP00000397833#ENSG00000112851#ENST00000416865#Other#LRR_1, LRR_4, LRR_5, LRR_8, PDZ, PDZ_2, RsmF_methy$#ENSP00000425728#ENSG00000112851#ENST00000511671#Other# FALSE 1987 ENSG00000082805 ERC1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR019018;IPR019323 23085 ELKS/RAB6-interacting/CAST family member 1 [Source:HGNC Symbol;Acc:HGNC:17072] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Yimeng Yin Jussi Taipale No $#ENSG00000082805#GO:0051092#positive regulation of NF-kappaB transcription factor activity#TAS - PMID:15218148 $#ENSP00000347621#ENSG00000082805#ENST00000355446#Other#ATG16, Cast, GAS, IncA, PKcGMP_CC$#ENSP00000354158#ENSG00000082805#ENST00000360905#Other#ATG16, Cast, GAS, IncA, PKcGMP_CC, RBD-FIP$#ENSP00000380386#ENSG00000082805#ENST00000397203#Other#Cast, IncA, PKcGMP_CC, RBD-FIP$#ENSP00000438546#ENSG00000082805#ENST00000543086#Other#Cast, IncA, PKcGMP_CC, RBD-FIP$#ENSP00000468263#ENSG00000082805#ENST00000589028#Other#ATG16, Cast, GAS, IncA, PKcGMP_CC, RBD-FIP$#ENSP00000479523#ENSG00000082805#ENST00000611180#Other#ATG16, Cast, IncA, Spc7$#ENSP00000467196#ENSG00000082805#ENST00000539802#Other#$#ENSP00000465628#ENSG00000082805#ENST00000545318#Other#$#ENSP00000464959#ENSG00000082805#ENST00000589132#Other# FALSE 1988 ENSG00000163161 ERCC3 Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None Binds DNA in the crystal structure (PDB: 5IY6). Protein is an ATP-dependent 3-5 DNA helicase, so likely non-specific. None None ERCC excision repair 3, TFIIH core complex helicase subunit 5IY6 not tested not tested None Binds DNA in the crystal structure (PDB: 5IY6). Protein is an ATP-dependent 3'-5' DNA helicase, so likely non-specific. No No No No New proteins added based on PDB entry Arttu Jolma Sam Lambert No None None FALSE 1989 ENSG00000175595 ERCC4 Unknown No ssDNA/RNA binding Not a DNA binding protein No motif None Binds ssDNA at splayed DNA (PDB: 2KN7) None None ERCC excision repair 4, endonuclease catalytic subunit 2KN7 not tested not tested None Binds ssDNA at splayed DNA (PDB: 2KN7) No No No No New proteins added based on PDB entry Arttu Jolma Sam Lambert No None None FALSE 1990 ENSG00000182944 EWSR1 Unknown No ssDNA/RNA binding Not a DNA binding protein No motif None None IPR000504;IPR001876 2130 EWS RNA binding protein 1 [Source:HGNC Symbol;Acc:HGNC:3508] None not tested Yes None Makes an oncogenic fusion protein with certain ETS-family members, but it does not contain DBDs as normal gene it is likely a RBP x No TF Gene_Transcription Factor Binding: tf co-factor binding; Basal Transcription Factor_TF PPI_PMIDS:9488465;11289149 No 4a, two or more datasets predict it as a TF Laura Campitelli Jussi Taipale No None $##ENSG00000182944##Other# FALSE 1991 ENSG00000174371 EXO1 Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None Makes contact with ssDNA bases at DNA breaks (PDB: 3QE9) None None exonuclease 1 3QE9 not tested not tested None Makes contact with ssDNA bases at DNA breaks (PDB: 3QE9) No No No No New proteins added based on PDB entry Arttu Jolma Sam Lambert No None None FALSE 1992 ENSG00000112685 EXOC2 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Plasma-membrane protein functioning in targeting of exocytic vesicles IPR002909;IPR014756;IPR029175; 55770 exocyst complex component 2 [Source:HGNC Symbol;Acc:HGNC:24968] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Sam Lambert Arttu Jolma No None $#ENSP00000230449#ENSG00000112685#ENST00000230449#Other#Sec5, TIG$#ENSP00000406400#ENSG00000112685#ENST00000443083#Other#TIG FALSE 1993 ENSG00000157036 EXOG Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None Endo/exonuclease (5-3), endonuclease G-like. Binds DNA in the crystal structure (PDB: 5T4I), presumably non-specifically None None endo/exonuclease (5'-3'), endonuclease G-like 5T4I not tested not tested None Endo/exonuclease (5'-3'), endonuclease G-like. Binds DNA in the crystal structure (PDB: 5T4I), presumably non-specifically No No No No New proteins added based on PDB entry Arttu Jolma Sam Lambert No None None FALSE 1994 ENSG00000108799 EZH1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Classic polycomb protein. IPR001005;IPR001214;IPR021654;IPR026489 2145 enhancer of zeste 1 polycomb repressive complex 2 subunit [Source:HGNC Symbol;Acc:HGNC:3526] None DBD and Full Yes None Its a histone methyltransferase, not likely to have any sequence specificity a No TF Gene Candidate__Transactivation_PMIDS:9214638 No 4a, two or more datasets predict it as a TF Tim Hughes Jussi Taipale No None $#ENSP00000407869#ENSG00000108799#ENST00000415827#Other#EZH2_WD-Binding, SET$#ENSP00000404658#ENSG00000108799#ENST00000428826#Other#EZH2_WD-Binding, SET$#ENSP00000464753#ENSG00000108799#ENST00000586382#Other#EZH2_WD-Binding$#ENSP00000467871#ENSG00000108799#ENST00000585893#Other#EZH2_WD-Binding, SET$#ENSP00000465220#ENSG00000108799#ENST00000590078#Other#SET$#ENSP00000466924#ENSG00000108799#ENST00000592743#Other#EZH2_WD-Binding, SET FALSE 1995 ENSG00000106462 EZH2 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None This is a classic polycomb protein with no evidence of sequence specific DNA binding after years of intense study. I dont see anything in (PMID :15520282) that supports DNA binding. IPR001005;IPR001214;IPR021654;IPR026489 2146 enhancer of zeste 2 polycomb repressive complex 2 subunit [Source:HGNC Symbol;Acc:HGNC:3527] None DBD and Full Yes None Its a histone methyltransferase, not likely to have any sequence specificity a No TF Gene_Transcription Factor Binding: tf co-factor binding; DNA-Binding: non-sequence-specific_Non-specific DNA; TF PPI_PMIDS:15520282 No 4a, two or more datasets predict it as a TF Tim Hughes Jussi Taipale No $#ENSG00000106462#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019 $#ENSP00000320147#ENSG00000106462#ENST00000320356#Other#EZH2_WD-Binding, SET$#ENSP00000223193#ENSG00000106462#ENST00000350995#Other#EZH2_WD-Binding, SET$#ENSP00000419711#ENSG00000106462#ENST00000460911#Other#EZH2_WD-Binding, SET$#ENSP00000419050#ENSG00000106462#ENST00000476773#Other#EZH2_WD-Binding, SET$#ENSP00000419856#ENSG00000106462#ENST00000483967#Other#EZH2_WD-Binding, SET FALSE 1996 ENSG00000131944 FAAP24 Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None Binds DNA backbone from the side of the minor groove in the crystal structure (PDB: 4BXO) None None Fanconi anemia core complex associated protein 24 4BXO not tested not tested None Binds DNA backbone from the side of the minor groove in the crystal structure (PDB: 4BXO) No No No No New proteins added based on PDB entry Arttu Jolma Sam Lambert No None None FALSE 1997 ENSG00000204677 FAM153C Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR023249 None family with sequence similarity 153 member C [Source:HGNC Symbol;Acc:HGNC:33936] None not tested not tested None None No Yes No No 5a, one of the source datasets predicts is as a TF Pratyush Das Jussi Taipale No None $#ENSP00000381177#ENSG00000204677#ENST00000398106#Other#FAM153$#ENSP00000424623#ENSG00000204677#ENST00000507848#Other#FAM153$#ENSP00000481919#ENSG00000204677#ENST00000620373#Other#FAM153$#ENSP00000422293#ENSG00000204677#ENST00000511856#Other#FAM153 FALSE 1998 ENSG00000144369 FAM171B Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif Has a putative AT-hook None IPR018890; 165215 family with sequence similarity 171 member B [Source:HGNC Symbol;Acc:HGNC:29412] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Sam Lambert Laura Campitelli No None $#ENSP00000304108#ENSG00000144369#ENST00000304698#Other#IncA, Prominin, UPF0560$#ENSP00000478477#ENSG00000144369#ENST00000612606#Other#UPF0560 FALSE 1999 ENSG00000221909 FAM200A Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None Protein of unknown function that is conserved in animalia. Has similarities to transposases and zinc fingers, and thus could be a DNA binding protein although there is no evidence supporting this IPR012337;IPR025398 221786 family with sequence similarity 200 member A [Source:HGNC Symbol;Acc:HGNC:25401] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Arttu Jolma Pratyush Das No $#ENSG00000221909#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000411372#ENSG00000221909#ENST00000449309#Other#DUF4371, Dimer_Tnp_hAT$#ENSP00000386191#ENSG00000221909#ENST00000408938#Other#DUF4371 FALSE 2000 ENSG00000198690 FAN1 Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None FANCD2 and FANCI associated nuclease 1. Binds DNA in the crystal structure (PDB: 4REA), presumably non-specifically None None None 4REA not tested not tested None None No No No No New proteins added based on PDB entry None None No None None FALSE 2001 ENSG00000187741 FANCA Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Involved in DNA repair (PMID: 8896564) None 2175 Fanconi anemia group A protein None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Yimeng Yin Laura Campitelli No $#ENSG00000187741#GO:0051090#regulation of sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019 $##ENSG00000187741##Other# FALSE 2002 ENSG00000144554 FANCD2 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None DNA repair protein. Inconclusive data supporting sequence-specific binding. Binds NFKB target sites in EMSA using 293T expressing FANCD2 (PMID: 21912593). Since the protein is expressed in mammalian cells, it could still be NFKB mediated binding. None 2177 Fanconi anemia group D2 protein None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Matt Weirauch Arttu Jolma No $#ENSG00000144554#GO:0051090#regulation of sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019 $##ENSG00000144554##Other# FALSE 2003 ENSG00000203780 FANK1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Binds JUN to control its activity (PMID: 20978819), but there is no evidence that it binds DNA itself None 92565 fibronectin type III and ankyrin repeat domains 1 [Source:HGNC Symbol;Acc:HGNC:23527] None not tested not tested None None No No No No 2a1, Lower confidence direct evidence Arttu Jolma Laura Campitelli No None $##ENSG00000203780##Other# FALSE 2004 ENSG00000179115 FARSA Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR002319;IPR004529;IPR006195;IPR013196 2193 phenylalanyl-tRNA synthetase alpha subunit [Source:HGNC Symbol;Acc:HGNC:3592] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Pratyush Das Laura Campitelli No None $#ENSP00000320309#ENSG00000179115#ENST00000314606#Other#HTH_11, MarR_2, tRNA-synt_2, tRNA-synt_2d$#ENSP00000396548#ENSG00000179115#ENST00000423140#Other#HTH_11, MarR_2, tRNA-synt_2, tRNA-synt_2d$#ENSP00000465402#ENSG00000179115#ENST00000587981#Other#HTH_11, MarR_2$#ENSP00000468384#ENSG00000179115#ENST00000587488#Other#tRNA-synt_2, tRNA-synt_2d FALSE 2005 ENSG00000116120 FARSB Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None tRNA synthetase IPR004531;IPR005146;IPR005147;IPR009061;IPR020825; 10056 phenylalanyl-tRNA synthetase beta subunit [Source:HGNC Symbol;Acc:HGNC:17800] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Pratyush Das Laura Campitelli No None $#ENSP00000281828#ENSG00000116120#ENST00000281828#Other#B3_4, B5 FALSE 2006 ENSG00000166147 FBN1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000152;IPR000742;IPR001881;IPR009030;IPR011398;IPR013032;IPR017878;IPR018097;IPR026823; 2200 Fibrillin 1 [Source:HGNC Symbol;Acc:HGNC:3603] None Full not tested None None x No No No 5a, one of the source datasets predicts is as a TF Matt Weirauch Jussi Taipale No None $#ENSP00000325527#ENSG00000166147#ENST00000316623#Other#EGF, EGF_3, EGF_CA, FXa_inhibition, Plasmod_Pvs28,$#ENSP00000453901#ENSG00000166147#ENST00000560355#Other# FALSE 2007 ENSG00000163013 FBXO41 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR001810; 150726 F-box protein 41 [Source:HGNC Symbol;Acc:HGNC:29409] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Sam Lambert Matt Weirauch No None $#ENSP00000295133#ENSG00000163013#ENST00000295133#Other#Atg14, DUF572, F-box, F-box-like$#ENSP00000430968#ENSG00000163013#ENST00000520530#Other#Atg14, DUF572, F-box, F-box-like$#ENSP00000428646#ENSG00000163013#ENST00000521871#Other#Atg14, DUF572, F-box, F-box-like FALSE 2008 ENSG00000168496 FEN1 Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None Involved in DNA replication. Binds DNA in the crystal structure (PDB: 3Q8K), presumably in a non-specific manner. None None flap structure-specific endonuclease 1 3Q8K not tested not tested None Involved in DNA replication. Binds DNA in the crystal structure (PDB: 3Q8K), presumably in a non-specific manner. No No No No New proteins added based on PDB entry Arttu Jolma Sam Lambert No None None FALSE 2009 ENSG00000151422 FER Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000719;IPR000980;IPR001060;IPR001245;IPR008266;IPR011009;IPR016250;IPR017441;IPR020635 2241 FER tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:3655] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Sam Lambert Matt Weirauch No $#ENSG00000151422#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IMP - PMID:21518868 $#ENSP00000281092#ENSG00000151422#ENST00000281092#Other#FCH, Pkinase, Pkinase_Tyr, SH2$#ENSP00000394297#ENSG00000151422#ENST00000438717#Other#Pkinase, Pkinase_Tyr, SH2$#ENSP00000484767#ENSG00000151422#ENST00000618353#Other#Opy2, Pkinase, Pkinase_Tyr, SH2$#ENSP00000486048#ENSG00000151422#ENST00000628534#Other#FCH FALSE 2010 ENSG00000102302 FGD1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000219;IPR000306;IPR001849;IPR017455 2245 FYVE, RhoGEF and PH domain containing 1 [Source:HGNC Symbol;Acc:HGNC:3663] None Full not tested None None x No No No 5a, one of the source datasets predicts is as a TF Matt Weirauch Pratyush Das No None $#ENSP00000364277#ENSG00000102302#ENST00000375135#Other#FYVE, FYVE_2, PH, PH_11, RhoGEF FALSE 2011 ENSG00000115641 FHL2 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None LIM ZF proteins are unlikely to bind DNA. Experimental evidence does not support a role for FHL2 as a sequence-specific DNA-binding protein (PMID:10654935) IPR001781 2274 four and a half LIM domains 2 [Source:HGNC Symbol;Acc:HGNC:3703] None not tested not tested None None No No TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:10654935 No 5a, one of the source datasets predicts is as a TF Sam Lambert Laura Campitelli No None $##ENSG00000115641##Other# FALSE 2012 ENSG00000196924 FLNA Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Go annotation is based on (PMID: 15684392), which shows that it binds FOXC1 and PBX1 but doesnt show evidence for binding to DNA IPR001298;IPR001589;IPR001715;IPR014756;IPR017868 2316 filamin A [Source:HGNC Symbol;Acc:HGNC:3754] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Sam Lambert Arttu Jolma No $#ENSG00000196924#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:15684392 $#ENSP00000353467#ENSG00000196924#ENST00000360319#Other#Big_3_5, CH, DUF5060, EMP24_GP25L, Filamin, Invasi$#ENSP00000358866#ENSG00000196924#ENST00000369850#Other#Big_3_5, CH, DUF5060, EMP24_GP25L, Filamin, Invasi$#ENSP00000358872#ENSG00000196924#ENST00000369856#Other#Big_3_5, CH, DUF5060, EMP24_GP25L, Filamin, Invasi$#ENSP00000397824#ENSG00000196924#ENST00000444578#Other#DUF5060, Filamin FALSE 2013 ENSG00000157827 FMNL2 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR010472;IPR010473;IPR014767;IPR014768;IPR015425;IPR016024;IPR017987; 114793 Formin like 2 [Source:HGNC Symbol;Acc:HGNC:18267] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Laura Campitelli Pratyush Das No None $#ENSP00000288670#ENSG00000157827#ENST00000288670#Other#Drf_FH3, Drf_GBD, FH2$#ENSP00000418959#ENSG00000157827#ENST00000475377#Other#FH2 FALSE 2014 ENSG00000162613 FUBP1 Unknown No ssDNA/RNA binding Not a DNA binding protein No motif Only known motifs are from Transfac or HocoMoco - origin is uncertain ssDNA binding protein with crystal structure demonstrating binding to ssDNA (PDB: 1J4W). Its a KH domain protein - this is Levens protein, known to impact the Myc promoter. IPR004087;IPR004088;IPR015096 8880 far upstream element binding protein 1 [Source:HGNC Symbol;Acc:HGNC:4004] 1J4W not tested not tested None Structure is with single-stranded DNA No Yes No Yes 2a1, Lower confidence direct evidence Matt Weirauch Laura Campitelli No $#ENSG00000162613#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:8125259 $#ENSP00000359804#ENSG00000162613#ENST00000370768#Other#DUF1897, KH_1, KH_2, KH_4, KH_5$#ENSP00000359803#ENSG00000162613#ENST00000370767#Other#DUF1897, KH_1, KH_2, KH_4, KH_5$#ENSP00000402630#ENSG00000162613#ENST00000421641#Other#KH_1, KH_2, KH_4 FALSE 2015 ENSG00000107164 FUBP3 Unknown No ssDNA/RNA binding Not a DNA binding protein No motif None Can bind single stranded DNA in a sequence specific manner (PMID: 8940189). Contans KH domains and has direct evidence it is an RNA-binding protein (PMID: 21252297) IPR004087;IPR004088 8939 far upstream element binding protein 3 [Source:HGNC Symbol;Acc:HGNC:4005] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Pratyush Das Arttu Jolma No $#ENSG00000107164#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:8940189 $#ENSP00000318177#ENSG00000107164#ENST00000319725#Other#DUF1897, KH_1, KH_2, KH_4, KH_5 FALSE 2016 ENSG00000089280 FUS Unknown No ssDNA/RNA binding Not a DNA binding protein No motif None FUS is a well-established RNA-binding protein IPR000504;IPR001876 2521 FUS RNA binding protein [Source:HGNC Symbol;Acc:HGNC:4010] None not tested not tested None None No No TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:11278855 No 5a, one of the source datasets predicts is as a TF Tim Hughes Sam Lambert No None $##ENSG00000089280##Other# FALSE 2017 ENSG00000157240 FZD1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000539;IPR017981;IPR020067 8321 frizzled class receptor 1 [Source:HGNC Symbol;Acc:HGNC:4038];Frizzled-1 None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Matt Weirauch Jussi Taipale No $#ENSG00000157240#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:10557084, PMID:14739301 $#ENSP00000287934#ENSG00000157240#ENST00000287934#Other#7tm_2, Dicty_CAR, Frizzled, Fz FALSE 2018 ENSG00000180340 FZD2 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Transmembrane receptor protein that operates far upstream in the signalling cascade IPR000539;IPR017981;IPR020067 2535 frizzled class receptor 2 [Source:HGNC Symbol;Acc:HGNC:4040] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Laura Campitelli Arttu Jolma No $#ENSG00000180340#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:18929644 $#ENSP00000323901#ENSG00000180340#ENST00000315323#Other#Frizzled, Fz FALSE 2019 ENSG00000174804 FZD4 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000539;IPR017981;IPR020067 8322 frizzled class receptor 4 [Source:HGNC Symbol;Acc:HGNC:4042] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Laura Campitelli Yimeng Yin No $#ENSG00000174804#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:14688793 $#ENSP00000434034#ENSG00000174804#ENST00000531380#Other#DUF5083, Frizzled, Fz FALSE 2020 ENSG00000164930 FZD6 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000539;IPR017981;IPR020067 8323 frizzled class receptor 6 [Source:HGNC Symbol;Acc:HGNC:4044] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Jussi Taipale Sam Lambert No $#ENSG00000164930#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:14747478 $#ENSP00000351605#ENSG00000164930#ENST00000358755#Other#Folate_rec, Frizzled, Fz$#ENSP00000429055#ENSG00000164930#ENST00000522566#Other#Folate_rec, Frizzled, Fz$#ENSP00000429528#ENSG00000164930#ENST00000523739#Other#Folate_rec, Frizzled, Fz FALSE 2021 ENSG00000104064 GABPB1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif Only known motifs are from Transfac or HocoMoco - origin is uncertain Evidence exists showing that GABPB1 (E4TF1-47/53) has no DNA binding activity, but can assocaite with GABPA (E4TF1-60; Ets factor) (PMID: 8441384). Crystal structure of GAPBP1 with GABPA (PDB: 1AWC) clearly shows that the protein makes an extensive protein-protein interaction with GABPA, but does not bind DNA. Transfac PWM is a clear ETS-motif, so GABP1 is unlikely to contact DNA directly IPR002110;IPR020683 55056 GA binding protein transcription factor beta subunit 1 [Source:HGNC Symbol;Acc:HGNC:4074] 1AWC not tested not tested None Structure is GABPB - GABPA heterodimer, GABPB does not appear to contact DNA, but it does come close. other Yes No Yes 2a1, Lower confidence direct evidence Yimeng Yin Laura Campitelli No $#ENSG00000104064#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:8441384 $#ENSP00000220429#ENSG00000104064#ENST00000220429#Other#Ank, Ank_2, Ank_3, Ank_4, Ank_5$#ENSP00000370259#ENSG00000104064#ENST00000380877#Other#Ank, Ank_2, Ank_3, Ank_4, Ank_5$#ENSP00000379728#ENSG00000104064#ENST00000396464#Other#Ank, Ank_2, Ank_3, Ank_4, Ank_5$#ENSP00000395771#ENSG00000104064#ENST00000429662#Other#Ank, Ank_2, Ank_3, Ank_4, Ank_5$#ENSP00000453463#ENSG00000104064#ENST00000560825#Other#Ank, Ank_2, Ank_3, Ank_4, Ank_5$#ENSP00000442500#ENSG00000104064#ENST00000543881#Other#Ank, Ank_2, Ank_3, Ank_4, Ank_5$#ENSP00000453578#ENSG00000104064#ENST00000558335#Other#Ank, Ank_2, Ank_3, Ank_4, Ank_5$#ENSP00000453806#ENSG00000104064#ENST00000561010#Other# FALSE 2022 ENSG00000143458 GABPB2 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Obligate heteromer with GABPB1 (the alpha subunit) (PMID: 8810337), which together interact with GABPA (PMID: 8441384), but neither contacts the DNA None 126626 GA-binding protein subunit beta-2 None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Yimeng Yin Matt Weirauch No $#ENSG00000143458#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $##ENSG00000143458##Other# FALSE 2023 ENSG00000116717 GADD45A Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Doesnt have any DBDs - likely a co-factor IPR004038;IPR029064 1647 growth arrest and DNA damage inducible alpha [Source:HGNC Symbol;Acc:HGNC:4095] None not tested Yes None None No No TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:10872826 No 5a, one of the source datasets predicts is as a TF Yimeng Yin Sam Lambert No None $##ENSG00000116717##Other# FALSE 2024 ENSG00000183087 GAS6 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000152;IPR000294;IPR000742;IPR001791;IPR001881;IPR009030;IPR013032;IPR013320;IPR018097 2621 Growth arrest-specific protein 6 None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Yimeng Yin Pratyush Das No $#ENSG00000183087#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:18680538 $#ENSP00000331831#ENSG00000183087#ENST00000327773#Other#EGF, EGF_3, EGF_CA, FXa_inhibition, Gla, Laminin_G FALSE 2025 ENSG00000007237 GAS7 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None (PMID: 9736752) only shows that it has a proline-rich domain similar to the one in Oct2. No evidence of DNA binding. IPR001060;IPR001202;IPR001452 8522 growth arrest specific 7 [Source:HGNC Symbol;Acc:HGNC:4169] None Full not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Tim Hughes Sam Lambert No $#ENSG00000007237#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:9736752 $#ENSP00000322608#ENSG00000007237#ENST00000323816#Other#DUF1664, FCH, WW, WW_FCH_linker$#ENSP00000407552#ENSG00000007237#ENST00000432992#Other#FCH, SH3_1, SH3_2, SH3_9, WW, WW_FCH_linker$#ENSP00000410108#ENSG00000007237#ENST00000437099#Other#DUF1664, FCH, WW, WW_FCH_linker$#ENSP00000443265#ENSG00000007237#ENST00000542249#Other#DUF1664, FCH, WW, WW_FCH_linker$#ENSP00000463527#ENSG00000007237#ENST00000579158#Other#DUF1664, FCH, WW, WW_FCH_linker$#ENSP00000463873#ENSG00000007237#ENST00000580865#Other#DUF1664, FCH, WW_FCH_linker$#ENSP00000464240#ENSG00000007237#ENST00000585266#Other#DUF1664, FCH, WW, WW_FCH_linker$#ENSP00000464494#ENSG00000007237#ENST00000578599#Other#WW, WW_FCH_linker FALSE 2026 ENSG00000005436 GCFC2 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None There is some evidence that this protein is an RNA-binding protein (PMID: 24304693). IPR022783 6936 GC-rich sequence DNA-binding factor 2 [Source:HGNC Symbol;Acc:HGNC:1317] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Arttu Jolma Pratyush Das No $#ENSG00000005436#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:9705290 $#ENSP00000318690#ENSG00000005436#ENST00000321027#Other#GCFC$#ENSP00000474481#ENSG00000005436#ENST00000470503#Other#$#ENSP00000437767#ENSG00000005436#ENST00000541687#Other#$#ENSP00000409340#ENSG00000005436#ENST00000427862#Other#GCFC$#ENSP00000475108#ENSG00000005436#ENST00000492826#Other# FALSE 2027 ENSG00000178295 GEN1 Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None Resolves Holliday junctions. Binds DNA in the crystal structure (PDB: 5T9J) None None GEN1, Holliday junction 5' flap endonuclease 5T9J not tested not tested None Resolves Holliday junctions. Binds DNA in the crystal structure (PDB: 5T9J) No No No No New proteins added based on PDB entry Arttu Jolma Sam Lambert No None None FALSE 2028 ENSG00000198715 GLMP Unknown Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Binds GATCCGCCCGCTTGTGGCCAACTGGCTCCAGTCAC dsDNA based on EMSA (PMID: 18021396) IPR029382 112770 glycosylated lysosomal membrane protein [Source:HGNC Symbol;Acc:HGNC:29436] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Pratyush Das Arttu Jolma No $#ENSG00000198715#GO:0003700#sequence-specific DNA binding transcription factor activity#IMP - PMID:18021396$#ENSG00000198715#GO:0004879#ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity#IMP - PMID:18021396 $#ENSP00000354553#ENSG00000198715#ENST00000362007#Other#NCU-G1$#ENSP00000480936#ENSG00000198715#ENST00000614643#Other#NCU-G1$#ENSP00000479149#ENSG00000198715#ENST00000622703#Other#NCU-G1$#ENSP00000477187#ENSG00000198715#ENST00000481050#Other#NCU-G1 FALSE 2029 ENSG00000173230 GOLGB1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Golgi resident transmembrane protein that regulates glycosylation of other proteins (PMID: 27226319) None 2804 Golgin subfamily B member 1 None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Arttu Jolma Pratyush Das No $#ENSG00000173230#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002 $##ENSG00000173230##Other# FALSE 2030 ENSG00000116580 GON4L Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Prosite identifies a low-confidence Myb-like domain (e.g., cant decide between Myb, SANT, or no DBD), so its probably not a TF IPR003822;IPR009057;IPR017877; 54856 gon-4 like [Source:HGNC Symbol;Acc:HGNC:25973] None DBD and Full not tested None None b No No No 5a, one of the source datasets predicts is as a TF Jussi Taipale Matt Weirauch No None $#ENSP00000354322#ENSG00000116580#ENST00000361040#Other#$#ENSP00000357315#ENSG00000116580#ENST00000368331#Other#Myb_DNA-bind_6, PAH$#ENSP00000483100#ENSG00000116580#ENST00000615926#Other#Myb_DNA-bind_6, PAH$#ENSP00000481460#ENSG00000116580#ENST00000620426#Other# FALSE 2031 ENSG00000186566 GPATCH8 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000467;IPR007087;IPR022755; 23131 G-patch domain containing 8 [Source:HGNC Symbol;Acc:HGNC:29066] None Full not tested None None x No No No 5a, one of the source datasets predicts is as a TF Pratyush Das Sam Lambert No None $#ENSP00000467556#ENSG00000186566#ENST00000591680#Other#G-patch, zf-C2H2_jaz, zf-met$#ENSP00000465781#ENSG00000186566#ENST00000585614#Other#G-patch, G-patch_2, zf-C2H2_2, zf-C2H2_jaz, zf-met FALSE 2032 ENSG00000062194 GPBP1 Unknown Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Solid data presented in (PMID: 14612417) Also known as Vasculin. (PMID: 26156556) also claims it has an extended AT hook. IPR028128 65056 GC-rich promoter binding protein 1 [Source:HGNC Symbol;Acc:HGNC:29520];Vasculin, Vasculin (also know None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Laura Campitelli Matt Weirauch No $#ENSG00000062194#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000264779#ENSG00000062194#ENST00000264779#Other#ELL, Vasculin$#ENSP00000421202#ENSG00000062194#ENST00000506184#Other#ELL, Vasculin$#ENSP00000421709#ENSG00000062194#ENST00000514387#Other#ELL, Vasculin$#ENSP00000422337#ENSG00000062194#ENST00000511209#Other#Vasculin FALSE 2033 ENSG00000159592 GPBP1L1 Unknown Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Possible TF based on similarity to GPBP1. Despite its name, no available evidence for DNA binding. Could also be an RBP according to this screen (PMID: 22658674) IPR028128 60313 GC-rich promoter binding protein 1 like 1 [Source:HGNC Symbol;Acc:HGNC:28843];Vasculin-like protein None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Matt Weirauch Pratyush Das No $#ENSG00000159592#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000347224#ENSG00000159592#ENST00000355105#Other#Vasculin$#ENSP00000290795#ENSG00000159592#ENST00000290795#Other#Vasculin FALSE 2034 ENSG00000164850 GPER1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000276;IPR017452 2852 G protein-coupled estrogen receptor 1 [Source:HGNC Symbol;Acc:HGNC:4485] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Pratyush Das Matt Weirauch No $#ENSG00000164850#GO:0017082#mineralocorticoid receptor activity#ISS - GO_REF:0000024 $#ENSP00000297469#ENSG00000164850#ENST00000297469#Other#7TM_GPCR_Srsx, 7tm_1$#ENSP00000380277#ENSG00000164850#ENST00000397088#Other#7TM_GPCR_Srsx, 7tm_1$#ENSP00000380281#ENSG00000164850#ENST00000397092#Other#7TM_GPCR_Srsx, 7tm_1$#ENSP00000385151#ENSG00000164850#ENST00000401670#Other#7TM_GPCR_Srsx, 7tm_1$#ENSP00000410487#ENSG00000164850#ENST00000413368#Other#$#ENSP00000483756#ENSG00000164850#ENST00000619052#Other# FALSE 2035 ENSG00000163328 GPR155 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000591;IPR004776 151556 G protein-coupled receptor 155 [Source:HGNC Symbol;Acc:HGNC:22951] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Jussi Taipale Sam Lambert No None $#ENSP00000295500#ENSG00000163328#ENST00000295500#Other#DEP, Mem_trans$#ENSP00000376334#ENSG00000163328#ENST00000392551#Other#DEP, Mem_trans$#ENSP00000376335#ENSG00000163328#ENST00000392552#Other#DEP, Mem_trans$#ENSP00000481104#ENSG00000163328#ENST00000614352#Other#DEP, Mem_trans FALSE 2036 ENSG00000166923 GREM1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None None None Gremlin-1 None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Yimeng Yin Pratyush Das No None None FALSE 2037 ENSG00000113262 GRM6 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000112;IPR000162;IPR000337;IPR001828;IPR011500;IPR017978;IPR017979;IPR028082 2916 glutamate metabotropic receptor 6 [Source:HGNC Symbol;Acc:HGNC:4598] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Laura Campitelli Pratyush Das No None $#ENSP00000231188#ENSG00000113262#ENST00000231188#Other#7tm_3, ANF_receptor, NCD3G, Peripla_BP_6$#ENSP00000430767#ENSG00000113262#ENST00000517717#Other#7tm_3, ANF_receptor, NCD3G, Peripla_BP_6 FALSE 2038 ENSG00000165417 GTF2A1 Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None General transcription factor. Binds DNA in the crystal structure (PDB: 5FUR). The protein contacts the DNA backbone as a heterotrimeric complex that also includes GTF2A2 and TBP. Has an extensive protein-protein interaction interface with the GTF2A2 (that does not contact the DNA) and will probably do nothing without it None None general transcription factor IIA subunit 1 5FUR not tested not tested None None No No No No New proteins added based on PDB entry None None No None None FALSE 2039 ENSG00000242441 GTF2A1L Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR004855;IPR009083;IPR009088; 11036 general transcription factor IIA subunit 1 like [Source:HGNC Symbol;Acc:HGNC:30727] None not tested not tested None None No No TF Gene_Basal Transcription Factor_Co-activation_PMIDS:12107178 No 5a, one of the source datasets predicts is as a TF Jussi Taipale Pratyush Das No None $#ENSP00000384597#ENSG00000242441#ENST00000403751#Other#TFIIA$#ENSP00000387896#ENSG00000242441#ENST00000430487#Other#TFIIA$#ENSP00000421474#ENSG00000242441#ENST00000508440#Other#TFIIA FALSE 2040 ENSG00000140307 GTF2A2 Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None GTF2A2 makes contacts with the DNA backbone (PDB:1NVP; PMID: 12972251), and thus is unlikely to be sequence-specific IPR003194;IPR009083;IPR009088;IPR015871;IPR015872 2958 general transcription factor IIA subunit 2 [Source:HGNC Symbol;Acc:HGNC:4647] 1NVP not tested not tested None Structure is GTF2A2 with TBP, presumably nonspecific component of preinitiation complex No No No Yes 3a, decent circumstantial evidence for its role as Sam Lambert Yimeng Yin No $#ENSG00000140307#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:8626665 $#ENSP00000379372#ENSG00000140307#ENST00000396060#Other#TFIIA_gamma_C, TFIIA_gamma_N$#ENSP00000379373#ENSG00000140307#ENST00000396061#Other#TFIIA_gamma_C, TFIIA_gamma_N$#ENSP00000379375#ENSG00000140307#ENST00000396063#Other#TFIIA_gamma_C, TFIIA_gamma_N$#ENSP00000418574#ENSG00000140307#ENST00000484743#Other#TFIIA_gamma_C, TFIIA_gamma_N$#ENSP00000452648#ENSG00000140307#ENST00000559706#Other#TFIIA_gamma_C, TFIIA_gamma_N$#ENSP00000379376#ENSG00000140307#ENST00000396064#Other#TFIIA_gamma_N FALSE 2041 ENSG00000137947 GTF2B Unknown Yes Known motif Low specificity DNA-binding protein In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain Contacts both DNA and TBP in the structure (PDB: 1C9B) IPR000812;IPR013137;IPR013150;IPR013763;IPR023486 2959 general transcription factor IIB [Source:HGNC Symbol;Acc:HGNC:4648] 1C9B not tested not tested None Structure has really big protein DNA-interaction interface No Yes TF Gene_Transcription Factor Binding: tf co-factor binding; Basal Transcription Factor_TF PPI_PMIDS:12972613;15037660;1729710;1922364;15749018;8621548;9420329;10546889 No 1a1, Direct HQ evidence Matt Weirauch Laura Campitelli No None $#ENSP00000359531#ENSG00000137947#ENST00000370500#Other#Cyclin_C, Cyclin_N, RB_B, TFIIB, TF_Zn_Ribbon$#ENSP00000402345#ENSG00000137947#ENST00000418217#Other#Cyclin_N, RB_B, TFIIB, TF_Zn_Ribbon$#ENSP00000415741#ENSG00000137947#ENST00000448623#Other#Cyclin_N, RB_B, TFIIB, TF_Zn_Ribbon FALSE 2042 ENSG00000197265 GTF2E2 Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None GTF2E2 weakly binds dsDNA (PMID: 10716934) - unlikely to be sequence-specific IPR003166;IPR016656 2961 general transcription factor IIE subunit 2 [Source:HGNC Symbol;Acc:HGNC:4651] 5IY6 not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Yimeng Yin Sam Lambert No None $#ENSP00000348168#ENSG00000197265#ENST00000355904#Other#TFIIE_beta$#ENSP00000429312#ENSG00000197265#ENST00000518445#Other#TFIIE_beta$#ENSP00000429921#ENSG00000197265#ENST00000518599#Other#TFIIE_beta FALSE 2043 ENSG00000125651 GTF2F1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Does not contact DNA in the structure (PDB: 5IY6) IPR008851;IPR011039 2962 general transcription factor IIF subunit 1 [Source:HGNC Symbol;Acc:HGNC:4652] 5IY6 not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Yimeng Yin Tim Hughes No None $#ENSP00000377969#ENSG00000125651#ENST00000394456#Other#TFIIF_alpha$#ENSP00000469091#ENSG00000125651#ENST00000593678#Other#TFIIF_alpha$#ENSP00000471542#ENSG00000125651#ENST00000598607#Other#TFIIF_alpha$#ENSP00000471403#ENSG00000125651#ENST00000595047#Other#TFIIF_alpha FALSE 2044 ENSG00000188342 GTF2F2 Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None The protein contacts DNA in the structure (PDB: 5IY6), and could thus have some specificity; DNA is contacted by domain folded from RKKKEDGKRARADKQHVLDMLFSAFEKHQYYNLKDLVDITKQPVVYLKEILKEIGVQNVKGIHKNTWELK. IPR003196;IPR011039 2963 general transcription factor IIF subunit 2 [Source:HGNC Symbol;Acc:HGNC:4653] 5IY6 not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Arttu Jolma Yimeng Yin No None $#ENSP00000340823#ENSG00000188342#ENST00000340473#Other#TFIIF_beta FALSE 2045 ENSG00000110768 GTF2H1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None General transcription factor IPR005607;IPR013876 2965 general transcription factor IIH subunit 1 [Source:HGNC Symbol;Acc:HGNC:4655] None not tested not tested None None No No TF Gene_Basal Transcription Factor_TF PPI_PMIDS:15220921 No 5a, one of the source datasets predicts is as a TF Laura Campitelli Jussi Taipale No None $##ENSG00000110768##Other# FALSE 2046 ENSG00000145736 GTF2H2 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None GTF2H2 (p44) is part of the TFIIH complex, but does not contact the DNA based on structural evidence (PDB: 5IVW) IPR002035;IPR004595;IPR007087;IPR007198;IPR012170; 2966 general transcription factor IIH subunit 2 [Source:HGNC Symbol;Acc:HGNC:4656] 5IVW not tested not tested None Contacts DNA in the structure with a long interaction interface, presumably nonspecific DNA-binder x No No Yes 3a, decent circumstantial evidence for its role as Sam Lambert Arttu Jolma No $#ENSG00000145736#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:8194529 $#ENSP00000274400#ENSG00000145736#ENST00000274400#Other#C1_4, Ssl1, VWA, VWA_2$#ENSP00000328901#ENSG00000145736#ENST00000330280#Other#C1_4, Ssl1, VWA, VWA_2$#ENSP00000429057#ENSG00000145736#ENST00000517900#Other#Ssl1, VWA_2$#ENSP00000473362#ENSG00000145736#ENST00000521602#Other# FALSE 2047 ENSG00000183474 GTF2H2C Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Protein is a transcriptional co-regulator (PMID: 9880511) IPR002035;IPR004595;IPR007087;IPR007198;IPR012170; 728340 GTF2H2 family member C [Source:HGNC Symbol;Acc:HGNC:31394] None not tested not tested None None x No TF Gene_Basal Transcription Factor; Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:9880511 No 4a, two or more datasets predict it as a TF Pratyush Das Arttu Jolma No None $#ENSP00000370105#ENSG00000183474#ENST00000380729#Other#C1_4, Ssl1, VWA, VWA_2$#ENSP00000422907#ENSG00000183474#ENST00000510979#Other#C1_4, Ssl1, VWA, VWA_2$#ENSP00000427224#ENSG00000183474#ENST00000512736#Other#Ssl1, VWA_2 FALSE 2048 ENSG00000111358 GTF2H3 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Pre-initiation complex component that does not contact DNA in the structure (PDB: 5IVW) IPR004600 2967 general transcription factor IIH subunit 3 [Source:HGNC Symbol;Acc:HGNC:4657] 5IVW not tested not tested None PIC-component No No No Yes 3a, decent circumstantial evidence for its role as Arttu Jolma Pratyush Das No $#ENSG00000111358#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:8194529 $#ENSP00000445162#ENSG00000111358#ENST00000543341#Other#Tfb4$#ENSP00000228955#ENSG00000111358#ENST00000228955#Other#Tfb4$#ENSP00000438435#ENSG00000111358#ENST00000543154#Other#Tfb4$#ENSP00000446429#ENSG00000111358#ENST00000539994#Other#Tfb4 FALSE 2049 ENSG00000213780 GTF2H4 Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None General transcription factor IPR004598 2968 general transcription factor IIH subunit 4 [Source:HGNC Symbol;Acc:HGNC:4658] 5IVW not tested not tested None None No No TF Gene_Basal Transcription Factor_TF PPI_PMIDS:9118947 No 5a, one of the source datasets predicts is as a TF Yimeng Yin Laura Campitelli No None $##ENSG00000213780##Other# FALSE 2050 ENSG00000077235 GTF3C1 Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None Component of RNA polymerase III. Binds weakly to the A-box (PMID: 8164661) IPR007309 2975 general transcription factor IIIC subunit 1 [Source:HGNC Symbol;Acc:HGNC:4664] None not tested not tested None None No No TF Gene_Basal Transcription Factor_Other_PMIDS:11419933 No 5a, one of the source datasets predicts is as a TF Arttu Jolma Yimeng Yin No None $##ENSG00000077235##Other# FALSE 2051 ENSG00000115207 GTF3C2 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain GTF3C2 is a general transcription factor of RNA polymerase III and there is no evidence that it binds DNA in the preinitiation complex. Transfac motifs are suspect IPR001680;IPR017986;IPR019775 2976 general transcription factor IIIC subunit 2 [Source:HGNC Symbol;Acc:HGNC:4665] None not tested not tested None None No Yes No No 2a1, Lower confidence direct evidence Arttu Jolma Pratyush Das No None $#ENSP00000264720#ENSG00000115207#ENST00000264720#Other#WD40$#ENSP00000352536#ENSG00000115207#ENST00000359541#Other#WD40$#ENSP00000393429#ENSG00000115207#ENST00000454704#Other#WD40$#ENSP00000399339#ENSG00000115207#ENST00000431028#Other#$#ENSP00000409043#ENSG00000115207#ENST00000457098#Other# FALSE 2052 ENSG00000189060 H1F0 Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None Histone. Likely a false-positive Pfam match based on the similarity of Forkhead domains to H1 domains IPR005818;IPR005819 3005 H1 histone family member 0 [Source:HGNC Symbol;Acc:HGNC:4714] None not tested not tested None None x Yes No No 4a, two or more datasets predict it as a TF Sam Lambert Pratyush Das No None $#ENSP00000344504#ENSG00000189060#ENST00000340857#Forkhead# FALSE 2053 ENSG00000178804 H1FOO Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None Variant linker histone protein that is expressed in oocytes IPR005818; 132243 H1 histone family member O, oocyte specific [Source:HGNC Symbol;Acc:HGNC:18463] None Full not tested None None x No No No 5a, one of the source datasets predicts is as a TF Jussi Taipale Arttu Jolma No None $#ENSP00000319799#ENSG00000178804#ENST00000324382#Other#Linker_histone$#ENSP00000422964#ENSG00000178804#ENST00000503977#Other# FALSE 2054 ENSG00000184897 H1FX Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None Histone component IPR005818;IPR005819 8971 H1 histone family member X [Source:HGNC Symbol;Acc:HGNC:4722] None Full not tested None None x No No No 5a, one of the source datasets predicts is as a TF Laura Campitelli Yimeng Yin No None $#ENSP00000329662#ENSG00000184897#ENST00000333762#Other#Linker_histone FALSE 2055 ENSG00000135077 HAVCR2 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR003599;IPR007110;IPR013106 84868 hepatitis A virus cellular receptor 2 [Source:HGNC Symbol;Acc:HGNC:18437] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Yimeng Yin Pratyush Das No $#ENSG00000135077#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IMP - PMID:22842346 $#ENSP00000312002#ENSG00000135077#ENST00000307851#Other#I-set, Ig_2, Ig_3, V-set, ig$#ENSP00000430328#ENSG00000135077#ENST00000524219#Other#$#ENSP00000430873#ENSG00000135077#ENST00000522593#Other#I-set, Ig_2, Ig_3, V-set, ig FALSE 2056 ENSG00000172534 HCFC1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Protein is recruited to promoters by THAP11 and ZNF143 and probably does not bind DNA by itself (PMID: 26416877) IPR003961;IPR006652 3054 host cell factor C1 [Source:HGNC Symbol;Acc:HGNC:4839] None not tested not tested None None No No TF Gene_Transcription Factor Binding: tf co-factor binding_Co-activation_PMIDS:12244100;15966902 Yes 4a, two or more datasets predict it as a TF Arttu Jolma Jussi Taipale No $#ENSG00000172534#GO:0001205#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involv#IEA - GO_REF:0000019$#ENSG00000172534#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:8392914 $#ENSP00000309555#ENSG00000172534#ENST00000310441#Other#Kelch_1, Kelch_2, Kelch_3, Kelch_4, Kelch_5, Kelch$#ENSP00000359001#ENSG00000172534#ENST00000369984#Other#Kelch_1, Kelch_2, Kelch_3, Kelch_4, Kelch_5, Kelch$#ENSP00000399589#ENSG00000172534#ENST00000444191#Other#fn3 FALSE 2057 ENSG00000101336 HCK Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Inhibits TP73-mediated transcription activation (PMID: 17535448) IPR000719;IPR000980;IPR001245;IPR001452;IPR008266;IPR011009;IPR017441;IPR020635 3055 HCK proto-oncogene, Src family tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:4840] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Jussi Taipale Laura Campitelli No $#ENSG00000101336#GO:0051090#regulation of sequence-specific DNA binding transcription factor activity#IMP - PMID:17535448 $#ENSP00000365012#ENSG00000101336#ENST00000375852#Other#Pkinase, Pkinase_Tyr, SH2, SH3_1, SH3_2, SH3_9$#ENSP00000365022#ENSG00000101336#ENST00000375862#Other#Pkinase, Pkinase_Tyr, SH2, SH3_1, SH3_2, SH3_9$#ENSP00000427757#ENSG00000101336#ENST00000518730#Other#Pkinase, Pkinase_Tyr, SH2, SH3_1, SH3_2, SH3_9$#ENSP00000429848#ENSG00000101336#ENST00000520553#Other#Pkinase, Pkinase_Tyr, SH2, SH3_1, SH3_2, SH3_9$#ENSP00000444986#ENSG00000101336#ENST00000534862#Other#Pkinase, Pkinase_Tyr, SH2, SH3_1, SH3_2, SH3_9$#ENSP00000441169#ENSG00000101336#ENST00000538448#Other#Pkinase, Pkinase_Tyr, SH2, SH3_1, SH3_2, SH3_9$#ENSP00000486627#ENSG00000101336#ENST00000629881#Other#Pkinase, Pkinase_Tyr, SH2, SH3_1, SH3_2, SH3_9 FALSE 2058 ENSG00000116478 HDAC1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif Only known motifs are from Transfac or HocoMoco - origin is uncertain Histone deacetylase; likely to be a transcriptional cofactor. Transfac motif is dubious, and the GO annotation (PMID: 8646880) seems to be based on remote homology to a yeast TF IPR000286;IPR003084;IPR023801 3065 histone deacetylase 1 [Source:HGNC Symbol;Acc:HGNC:4852] None not tested not tested None None No Yes TF Gene_Transcription Factor Binding: tf co-factor binding_Co-activation_PMIDS:15919722 Yes 2a1, Lower confidence direct evidence Sam Lambert Jussi Taipale No $#ENSG00000116478#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:8646880 $#ENSP00000362649#ENSG00000116478#ENST00000373548#Other#Hist_deacetyl$#ENSP00000407859#ENSG00000116478#ENST00000428704#Other#Hist_deacetyl FALSE 2059 ENSG00000100429 HDAC10 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Histone deacetylase; likely to be a transcriptional cofactor IPR000286;IPR023801 83933 histone deacetylase 10 [Source:HGNC Symbol;Acc:HGNC:18128] None not tested not tested None None No No TF Gene_Transcription Regulatory Activity: heterochromatin interaction/binding_Non-specific DNA; TF PPI_PMIDS:11861901 No 5a, one of the source datasets predicts is as a TF Laura Campitelli Pratyush Das No None $##ENSG00000100429##Other# FALSE 2060 ENSG00000196591 HDAC2 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif Only known motifs are from Transfac or HocoMoco - origin is uncertain Histone deacetylase; likely to be a transcriptional cofactor IPR000286;IPR003084;IPR023801 3066 histone deacetylase 2 [Source:HGNC Symbol;Acc:HGNC:4853] None not tested not tested None None No Yes TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:11836251 Yes 2a1, Lower confidence direct evidence Pratyush Das Yimeng Yin No $#ENSG00000196591#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#IMP - PMID:19041327 $#ENSP00000430432#ENSG00000196591#ENST00000519065#Other#Hist_deacetyl$#ENSP00000357621#ENSG00000196591#ENST00000368632#Other#Hist_deacetyl$#ENSP00000417026#ENSG00000196591#ENST00000425835#Other#Hist_deacetyl$#ENSP00000430008#ENSG00000196591#ENST00000519108#Other#Hist_deacetyl FALSE 2061 ENSG00000171720 HDAC3 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Histone deacetylase; likely to be a transcriptional cofactor IPR000286;IPR003084;IPR023801 8841 histone deacetylase 3 [Source:HGNC Symbol;Acc:HGNC:4854] None not tested not tested None None No No TF Gene_Transcription Factor Binding: tf co-factor binding_Co-activation; TF PPI_PMIDS:10860984;10944117;15561719 No 5a, one of the source datasets predicts is as a TF Pratyush Das Arttu Jolma No None $##ENSG00000171720##Other# FALSE 2062 ENSG00000068024 HDAC4 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Histone deacetylase; likely to be a transcriptional cofactor IPR000286;IPR017320;IPR019154;IPR023801;IPR024643 9759 histone deacetylase 4 [Source:HGNC Symbol;Acc:HGNC:14063] None not tested not tested None None No No TF Gene_Transcription Factor Binding: tf co-factor binding_Co-activation_PMIDS:15537544 Yes 4a, two or more datasets predict it as a TF Jussi Taipale Laura Campitelli No $#ENSG00000068024#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#IMP - PMID:18850004$#ENSG00000068024#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IMP - PMID:19071119 $#ENSP00000264606#ENSG00000068024#ENST00000345617#Other#HDAC4_Gln, Hist_deacetyl$#ENSP00000410551#ENSG00000068024#ENST00000430200#Other#Hist_deacetyl$#ENSP00000391226#ENSG00000068024#ENST00000445704#Other# FALSE 2063 ENSG00000108840 HDAC5 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Histone deacetylase; likely to be a transcriptional cofactor IPR000286;IPR017320;IPR023801;IPR024643 10014 histone deacetylase 5 [Source:HGNC Symbol;Acc:HGNC:14068] None not tested not tested None None No No TF Gene_Transcription Factor Binding: tf co-factor binding_Other_PMIDS:11467738;11902574;12943985;15140878 Yes 4a, two or more datasets predict it as a TF Yimeng Yin Sam Lambert No $#ENSG00000108840#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IMP - PMID:19071119 $#ENSP00000337290#ENSG00000108840#ENST00000336057#Other#HDAC4_Gln, Hist_deacetyl$#ENSP00000468004#ENSG00000108840#ENST00000586802#Other#HDAC4_Gln, Hist_deacetyl$#ENSP00000465393#ENSG00000108840#ENST00000587135#Other#$#ENSP00000465227#ENSG00000108840#ENST00000588261#Other#$#ENSP00000465229#ENSG00000108840#ENST00000588703#Other#HDAC4_Gln$#ENSP00000468485#ENSG00000108840#ENST00000591714#Other# FALSE 2064 ENSG00000094631 HDAC6 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Histone deacetylase; likely to be a transcriptional cofactor IPR000286;IPR001607;IPR023801 10013 histone deacetylase 6 [Source:HGNC Symbol;Acc:HGNC:14064] None not tested not tested None None No No TF Gene_Transcription Factor Binding: tf co-factor binding_Co-activation_PMIDS:12372765;15102857 No 5a, one of the source datasets predicts is as a TF Jussi Taipale Yimeng Yin No None $##ENSG00000094631##Other# FALSE 2065 ENSG00000061273 HDAC7 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Histone deacetylase; likely to be a transcriptional cofactor IPR000286;IPR017320;IPR023801 51564 histone deacetylase 7 [Source:HGNC Symbol;Acc:HGNC:14067] None not tested not tested None None No No TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:12753745;15166223;15280364;11585834;12753745 No 5a, one of the source datasets predicts is as a TF Tim Hughes Arttu Jolma No None $##ENSG00000061273##Other# FALSE 2066 ENSG00000147099 HDAC8 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000286;IPR003084;IPR023801 55869 histone deacetylase 8 [Source:HGNC Symbol;Acc:HGNC:13315] None not tested not tested None None No No TF Gene_Transcription Factor Binding: tf co-factor binding_Co-activation_PMIDS:10748112 No 5a, one of the source datasets predicts is as a TF Sam Lambert Arttu Jolma No None $##ENSG00000147099##Other# FALSE 2067 ENSG00000048052 HDAC9 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Histone deacetylase; likely to be a transcriptional cofactor IPR000286;IPR017320;IPR023801;IPR024643 9734 histone deacetylase 9 [Source:HGNC Symbol;Acc:HGNC:14065] 1TQE not tested not tested None Structure has just a small peptide from HDAC9, that does not contact the DNA but contacts MEF2B through PPI No No TF Gene_Transcription Regulatory Activity: heterochromatin interaction/binding; Transcription Factor Binding: tf co-factor binding_TF PPI; Transactivation_PMIDS:11535832;12242305 No 5a, one of the source datasets predicts is as a TF Arttu Jolma Jussi Taipale No None $##ENSG00000048052##Other# FALSE 2068 ENSG00000130589 HELZ2 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR012340;IPR022966;IPR027417; 85441 helicase with zinc finger 2 [Source:HGNC Symbol;Acc:HGNC:30021] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Yimeng Yin Sam Lambert No None $#ENSP00000393257#ENSG00000130589#ENST00000427522#Other#AAA_11, AAA_12, AAA_19, AAA_22, AAA_30, DUF2075, P$#ENSP00000417401#ENSG00000130589#ENST00000467148#Other#AAA_11, AAA_12, AAA_19, AAA_22, AAA_30, DUF2075, P FALSE 2069 ENSG00000064393 HIPK2 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Transcriptional cofactor that can act as a coactivator or corepressor. Phosphorylates many transcription factors. (UniProt Q9H2X6) IPR000719;IPR002290;IPR008271;IPR011009;IPR017441 28996 homeodomain interacting protein kinase 2 [Source:HGNC Symbol;Acc:HGNC:14402] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Laura Campitelli Pratyush Das No $#ENSG00000064393#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024 $#ENSP00000385571#ENSG00000064393#ENST00000406875#Other#APH, Kdo, Pkinase, Pkinase_Tyr$#ENSP00000413724#ENSG00000064393#ENST00000428878#Other#APH, Kdo, Pkinase, Pkinase_Tyr$#ENSP00000343108#ENSG00000064393#ENST00000342645#Other#APH, Kdo, Pkinase, Pkinase_Tyr FALSE 2070 ENSG00000100084 HIRA Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif Has a putative AT-hook Histone chaperone - TUP1 homolog. IPR001680;IPR011494;IPR017986;IPR019015;IPR019775 7290 histone cell cycle regulator [Source:HGNC Symbol;Acc:HGNC:4916] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Jussi Taipale Matt Weirauch No $#ENSG00000100084#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:9731536 $#ENSP00000263208#ENSG00000100084#ENST00000263208#Other#ANAPC4_WD40, HIRA_B, Hira, Mcl1_mid, WD40$#ENSP00000345350#ENSG00000100084#ENST00000340170#Other#ANAPC4_WD40, HIRA_B, Hira, WD40 FALSE 2071 ENSG00000124610 HIST1H1A Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None Histone component IPR005818;IPR005819 3024 histone cluster 1, H1a [Source:HGNC Symbol;Acc:HGNC:4715] None not tested not tested None Histone_Core_Protein x No No No 5a, one of the source datasets predicts is as a TF Pratyush Das Laura Campitelli No None $#ENSP00000244573#ENSG00000124610#ENST00000244573#Other#Linker_histone FALSE 2072 ENSG00000184357 HIST1H1B Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None Linker histone. To my knowledge there has been no demonstration of sequence specificity of linker histones, so I think this one should be called unlikely. IPR005818;IPR005819 3009 histone cluster 1, H1b [Source:HGNC Symbol;Acc:HGNC:4719] None not tested not tested None Histone_Core_Protein x No No No 5a, one of the source datasets predicts is as a TF Jussi Taipale Pratyush Das No None $#ENSP00000330074#ENSG00000184357#ENST00000331442#Other#Linker_histone FALSE 2073 ENSG00000187837 HIST1H1C Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None None IPR005818;IPR005819 3006 histone cluster 1, H1c [Source:HGNC Symbol;Acc:HGNC:4716] None not tested not tested None Histone_Core_Protein x No No No 5a, one of the source datasets predicts is as a TF Sam Lambert Pratyush Das No None $#ENSP00000339566#ENSG00000187837#ENST00000343677#Other#Linker_histone FALSE 2074 ENSG00000124575 HIST1H1D Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None Linker histone that binds DNA as heteromeric complex with the other histone proteins IPR005818;IPR005819 3007 histone cluster 1, H1d [Source:HGNC Symbol;Acc:HGNC:4717] None not tested not tested None Histone_Core_Protein x No No No 5a, one of the source datasets predicts is as a TF Arttu Jolma Laura Campitelli No None $#ENSP00000244534#ENSG00000124575#ENST00000244534#Other#Linker_histone FALSE 2075 ENSG00000168298 HIST1H1E Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None Binds DNA as heteromultimeric complex IPR005818;IPR005819 3008 histone cluster 1, H1e [Source:HGNC Symbol;Acc:HGNC:4718] None Full not tested None Histone_Core_Protein x No No No 5a, one of the source datasets predicts is as a TF Arttu Jolma Laura Campitelli No None $#ENSP00000307705#ENSG00000168298#ENST00000304218#Other#Linker_histone FALSE 2076 ENSG00000187475 HIST1H1T Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None None IPR005818;IPR005819 3010 histone cluster 1, H1t [Source:HGNC Symbol;Acc:HGNC:4720] None Full not tested None Histone_Core_Protein x No No No 5a, one of the source datasets predicts is as a TF Pratyush Das Sam Lambert No None $#ENSP00000341214#ENSG00000187475#ENST00000338379#Other#Linker_histone FALSE 2077 ENSG00000179344 HLA-DQB1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000353;IPR003006;IPR003597;IPR007110;IPR011162; 3119 major histocompatibility complex, class II, DQ beta 1 [Source:HGNC Symbol;Acc:HGNC:4944] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Jussi Taipale Arttu Jolma No None $#ENSP00000364080#ENSG00000179344#ENST00000374943#Other#C1-set, C2-set_2, Ig_3, MHC_I, MHC_II_beta, ig$#ENSP00000382029#ENSG00000179344#ENST00000399079#Other#C1-set, C2-set_2, Ig_3, MHC_I, MHC_II_beta, ig$#ENSP00000382032#ENSG00000179344#ENST00000399082#Other#C1-set, C2-set_2, Ig_2, Ig_3, ig$#ENSP00000382034#ENSG00000179344#ENST00000399084#Other#C1-set, C2-set_2, Ig_3, MHC_I, MHC_II_beta, ig$#ENSP00000407332#ENSG00000179344#ENST00000434651#Other#C1-set, C2-set_2, Ig_3, MHC_I, MHC_II_beta, ig FALSE 2078 ENSG00000232629 HLA-DQB2 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None None None major histocompatibility complex, class II, DQ beta 2 [Source:HGNC Symbol;Acc:HGNC:4944] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Jussi Taipale Laura Campitelli No None None FALSE 2079 ENSG00000196126 HLA-DRB1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000353;IPR003006;IPR003597;IPR007110;IPR011162; 3123 major histocompatibility complex, class II, DR beta 1 [Source:HGNC Symbol;Acc:HGNC:4948] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Sam Lambert Jussi Taipale No None $#ENSP00000353099#ENSG00000196126#ENST00000360004#Other#C1-set, Ig_3, MHC_II_beta, ig$#ENSP00000480667#ENSG00000196126#ENST00000611060#Other#C1-set, Ig_3, MHC_II_beta, ig FALSE 2080 ENSG00000196101 HLA-DRB3 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None None None major histocompatibility complex, class II, DR beta 3 None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Jussi Taipale Arttu Jolma No None None FALSE 2081 ENSG00000198502 HLA-DRB5 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000353;IPR003006;IPR003597;IPR007110;IPR011162; 3127 major histocompatibility complex, class II, DR beta 5 [Source:HGNC Symbol;Acc:HGNC:4953] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Jussi Taipale Laura Campitelli No None $#ENSP00000364114#ENSG00000198502#ENST00000374975#Other#C1-set, Ig_3, MHC_II_beta, ig FALSE 2082 ENSG00000071794 HLTF Unknown No ssDNA/RNA binding Not a DNA binding protein In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain DNA repair protein. Even though it has 3 motifs, there is no compelling evidence that it really binds dsDNA - only single stranded DNA IPR000330;IPR001650;IPR001841;IPR014001;IPR014905;IPR017907;IPR027417 6596 helicase like transcription factor [Source:HGNC Symbol;Acc:HGNC:11099] 4S0N not tested not tested None Structure has only small fragments of ssDNA No Yes TF Gene Candidate_Transcription Regulatory Activity: heterochromatin interaction/binding_DNA Binding_PMIDS:9427542 No 2a1, Lower confidence direct evidence Sam Lambert Matt Weirauch No $#ENSG00000071794#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019 $#ENSP00000308944#ENSG00000071794#ENST00000310053#Other#HIRAN, Helicase_C, Prok-RING_4, ResIII, SNF2_N, zf$#ENSP00000376644#ENSG00000071794#ENST00000392912#Other#HIRAN, Helicase_C, Prok-RING_4, ResIII, SNF2_N, zf$#ENSP00000420745#ENSG00000071794#ENST00000465259#Other#HIRAN, Helicase_C, Prok-RING_4, ResIII, SNF2_N, zf$#ENSP00000420429#ENSG00000071794#ENST00000494055#Other#HIRAN, Helicase_C, Prok-RING_4, ResIII, SNF2_N, zf FALSE 2083 ENSG00000100292 HMOX1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Well characterized enzyme with no additional domains. Included only because GO lists it as a regulator of TFs. No support for DNA binding activity. IPR002051;IPR016053;IPR016084;IPR018207 3162 heme oxygenase 1 [Source:HGNC Symbol;Acc:HGNC:5013] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Tim Hughes Laura Campitelli No $#ENSG00000100292#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019$#ENSG00000100292#GO:0051090#regulation of sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024 $#ENSP00000216117#ENSG00000100292#ENST00000216117#Other#Heme_oxygenase$#ENSP00000413316#ENSG00000100292#ENST00000412893#Other#Heme_oxygenase FALSE 2084 ENSG00000135486 HNRNPA1 Unknown No ssDNA/RNA binding Not a DNA binding protein No motif None Binds single stranded DNA in the structure (PDB: 1PGZ) None None heterogeneous nuclear ribonucleoprotein A1 1PGZ not tested not tested None Binds single stranded DNA in the structure (PDB: 1PGZ) No No No No New proteins added based on PDB entry Arttu Jolma Sam Lambert No None None FALSE 2085 ENSG00000170144 HNRNPA3 Unknown No ssDNA/RNA binding Not a DNA binding protein No motif None Protein is a well established RBP IPR000504;IPR021662 100616394 heterogeneous nuclear ribonucleoprotein A3 [Source:HGNC Symbol;Acc:HGNC:24941] None not tested not tested None None No No TF Evidence Conflict - There is evidence for and against this genes role as a TF_Transcription Factor Binding: tf co-factor binding__PMIDS:0 No 5a, one of the source datasets predicts is as a TF Sam Lambert Arttu Jolma No None $##ENSG00000170144##Other# FALSE 2086 ENSG00000197451 HNRNPAB Unknown No ssDNA/RNA binding Not a DNA binding protein No motif None HNRNPAB proteins are involved in pre-mRNA splicing. However; RRM domains can also constitute ssDNA binding domains IPR000504;IPR012956 3182 Heterogeneous nuclear ribonucleoprotein A/B [Source:HGNC Symbol;Acc:HGNC:5034] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Pratyush Das Sam Lambert No $#ENSG00000197451#GO:0003700#sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024 $#ENSP00000348093#ENSG00000197451#ENST00000355836#Other#CBFNT$#ENSP00000351108#ENSG00000197451#ENST00000358344#Other#CBFNT$#ENSP00000425031#ENSG00000197451#ENST00000504898#Other#CBFNT$#ENSP00000427465#ENSG00000197451#ENST00000506259#Other#CBFNT FALSE 2087 ENSG00000275774 HNRNPCL2 Unknown No ssDNA/RNA binding Not a DNA binding protein No motif None Protein is a well established RBP IPR000504;IPR017347 440563 heterogeneous nuclear ribonucleoprotein C-like 2 [Source:HGNC Symbol;Acc:HGNC:48813] None not tested not tested None None No No TF Evidence Conflict - There is evidence for and against this genes role as a TF_Transcription Factor Binding: tf co-factor binding; DNA-Binding: sequence-specific_Other_PMIDS:16010978;16217013 No 5a, one of the source datasets predicts is as a TF Arttu Jolma Jussi Taipale No None $##ENSG00000275774##Other# FALSE 2088 ENSG00000138668 HNRNPD Unknown No ssDNA/RNA binding Not a DNA binding protein No motif None Binds single stranded DNA in the structure (PDB: 1WTB) None None heterogeneous nuclear ribonucleoprotein D 1WTB not tested not tested None Binds single stranded DNA in the structure (PDB: 1WTB) No No Probably Not a TF - No evidence that it is a TF___PMIDS:0 No New proteins added based on PDB entry Arttu Jolma Sam Lambert No None None FALSE 2089 ENSG00000152795 HNRNPDL Unknown No ssDNA/RNA binding Not a DNA binding protein No motif None Protein is a well established RBP IPR000504 9987 heterogeneous nuclear ribonucleoprotein D like [Source:HGNC Symbol;Acc:HGNC:5037] None not tested not tested None None No No TF Gene Candidate_Single stranded RNA/DNA binding_Non-specific DNA_PMIDS:9538234 No 5a, one of the source datasets predicts is as a TF Pratyush Das Laura Campitelli No None $##ENSG00000152795##Other# FALSE 2090 ENSG00000165119 HNRNPK Unknown No ssDNA/RNA binding Not a DNA binding protein No motif None Protein is a well established RBP IPR004087;IPR004088;IPR012987 407043 heterogeneous nuclear ribonucleoprotein K [Source:HGNC Symbol;Acc:HGNC:5044] 1J5K not tested not tested None Structure is with ssDNA No No TF Gene_Single stranded RNA/DNA binding_Co-activation; DNA Binding; TF PPI; Transactivation_PMIDS:8628302;8650178 Yes 3a, decent circumstantial evidence for its role as Jussi Taipale Yimeng Yin No $#ENSG00000165119#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IMP - PMID:20371611 $#ENSP00000317788#ENSG00000165119#ENST00000351839#Other#KH_1, KH_2, KH_4, KH_5, ROKNT$#ENSP00000353552#ENSG00000165119#ENST00000360384#Other#KH_1, KH_2, KH_4, KH_5, ROKNT$#ENSP00000365439#ENSG00000165119#ENST00000376263#Other#KH_1, KH_2, KH_4, KH_5, ROKNT$#ENSP00000365458#ENSG00000165119#ENST00000376281#Other#KH_1, KH_2, KH_4, KH_5, ROKNT$#ENSP00000473957#ENSG00000165119#ENST00000481820#Other#KH_1, KH_2 FALSE 2091 ENSG00000104824 HNRNPL Unknown No ssDNA/RNA binding Not a DNA binding protein No motif None HNRNPL is a well-established RNA-binding protein; and the DNA-binding evidence was neither shown to be specific or direct (PMID: 11809897) IPR000504;IPR006536 3191 heterogeneous nuclear ribonucleoprotein L [Source:HGNC Symbol;Acc:HGNC:5045] None not tested not tested None None No No TF Evidence Conflict - There is evidence for and against this genes role as a TF_Transcription Factor Binding: tf co-factor binding_Co-activation_PMIDS:11809897 No 5a, one of the source datasets predicts is as a TF Laura Campitelli Sam Lambert No None $##ENSG00000104824##Other# FALSE 2092 ENSG00000153187 HNRNPU Unknown No ssDNA/RNA binding Not a DNA binding protein No motif None Binds pre-mRNA in vivo and binds both RNA and ssDNA in vitro (PMID: 1628625) IPR001870;IPR003034;IPR003877;IPR013320;IPR027417 3192 heterogeneous nuclear ribonucleoprotein U [Source:HGNC Symbol;Acc:HGNC:5048] None not tested not tested None None No No TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_TF PPI; Transactivation_PMIDS:9353307;15096513 No 5a, one of the source datasets predicts is as a TF Pratyush Das Laura Campitelli No None $##ENSG00000153187##Other# FALSE 2093 ENSG00000127483 HP1BP3 Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None Histone H1-like protein. Binds in ChIP experiments (PMID: 27425409) and binds DNA (likely non-specifically) with HP1. IPR005818;IPR005819 50809 heterochromatin protein 1 binding protein 3 [Source:HGNC Symbol;Acc:HGNC:24973] None Full Yes None None x No No No 5a, one of the source datasets predicts is as a TF Pratyush Das Matt Weirauch No None $#ENSP00000364139#ENSG00000127483#ENST00000375000#Other#$#ENSP00000364142#ENSG00000127483#ENST00000375003#Other#Linker_histone, YL1$#ENSP00000312625#ENSG00000127483#ENST00000312239#Other#Linker_histone, SDA1, YL1$#ENSP00000402754#ENSG00000127483#ENST00000424732#Other#Linker_histone$#ENSP00000402096#ENSG00000127483#ENST00000437575#Other#$#ENSP00000401874#ENSG00000127483#ENST00000443615#Other# FALSE 2094 ENSG00000168453 HR Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None JmjC domain is not a DBD, and GO annotation is based on homology to a zinc finger motif and not experimental DNA-binding evidence (PMID: 9445480) IPR003347 55806 hair growth associated [Source:HGNC Symbol;Acc:HGNC:5172];Lysine-specific demethylase hairless None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Sam Lambert Pratyush Das No $#ENSG00000168453#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:9445480 $#ENSP00000370826#ENSG00000168453#ENST00000381418#Other#JmjC$#ENSP00000326765#ENSG00000168453#ENST00000312841#Other# FALSE 2095 ENSG00000230989 HSBP1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Protein that has been shown to bind to HSF1 leading to inhibition of its trimerization and DNA-binding( PMID: 9649501). IPR009643 3281 heat shock factor binding protein 1 [Source:HGNC Symbol;Acc:HGNC:5203] None not tested not tested None None No No Indeterminate - There is no evidence for or against this genes role as a TF__Transactivation_PMIDS:12038984 No 5a, one of the source datasets predicts is as a TF Pratyush Das Arttu Jolma No None $##ENSG00000230989##Other# FALSE 2096 ENSG00000204389 HSPA1A Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR013126;IPR018181;IPR029047;IPR029048 3303 heat shock protein family A (Hsp70) member 1A [Source:HGNC Symbol;Acc:HGNC:5232] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Jussi Taipale Sam Lambert No $#ENSG00000204389#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IMP - PMID:24790089 $#ENSP00000477378#ENSG00000204389#ENST00000608703#Other#FGGY_C, FtsA, HSP70, MreB_Mbl$#ENSP00000364802#ENSG00000204389#ENST00000375651#Other#FGGY_C, FtsA, HSP70, MreB_Mbl FALSE 2097 ENSG00000204388 HSPA1B Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR013126;IPR018181;IPR029047;IPR029048 None heat shock protein family A (Hsp70) member 1B [Source:HGNC Symbol;Acc:HGNC:5233] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Jussi Taipale Yimeng Yin No None None FALSE 2098 ENSG00000090339 ICAM1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None None 3383 Intercellular adhesion molecule 1 None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Laura Campitelli Yimeng Yin No $#ENSG00000090339#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IEA - GO_REF:0000019 $##ENSG00000090339##Other# FALSE 2099 ENSG00000163565 IFI16 Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None Recognizes DNA without sequence specificity (PMID: 22618232; PMID: 18472023) IPR004020;IPR004021;IPR011029; 3428 interferon gamma inducible protein 16 [Source:HGNC Symbol;Acc:HGNC:5395] 3RNU not tested not tested None Structure has a dsDNA bound proteins, presumably nonspecific protein that recognizes dsDNA in cytosol as a part of innate immune system other No No Yes 3a, decent circumstantial evidence for its role as Yimeng Yin Matt Weirauch No $#ENSG00000163565#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:24413532 $#ENSP00000357113#ENSG00000163565#ENST00000368131#Other#HIN, PYRIN, tRNA_anti-codon$#ENSP00000357114#ENSG00000163565#ENST00000368132#Other#HIN, PYRIN, tRNA_anti-codon$#ENSP00000352740#ENSG00000163565#ENST00000359709#Other#HIN, PYRIN, tRNA_anti-codon$#ENSP00000456129#ENSG00000163565#ENST00000474473#Other#HIN$#ENSP00000458084#ENSG00000163565#ENST00000566111#Other#PYRIN FALSE 2100 ENSG00000171855 IFNB1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000471;IPR009079 3456 interferon beta 1 [Source:HGNC Symbol;Acc:HGNC:5434] None not tested not tested None None No Yes No No 5a, one of the source datasets predicts is as a TF Sam Lambert Matt Weirauch No None $#ENSP00000369581#ENSG00000171855#ENST00000380232#Other#Interferon FALSE 2101 ENSG00000211899 IGHM Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None None None Immunoglobulin heavy constant mu [Source:HGNC Symbol;Acc:HGNC:5541] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Sam Lambert Pratyush Das No None $##ENSG00000211899##Other# FALSE 2102 ENSG00000104365 IKBKB Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000626;IPR000719;IPR001245;IPR002290;IPR008271;IPR011009;IPR022007;IPR029071 3551 inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta [Source:HGNC Symbol;Acc:H None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Yimeng Yin Jussi Taipale No $#ENSG00000104365#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IDA - PMID:15790681 | TAS - PMID:18626576, Reactom $#ENSP00000430483#ENSG00000104365#ENST00000519735#Other#APH, Kdo, Pkinase, Pkinase_Tyr, YrbL-PhoP_reg$#ENSP00000430684#ENSG00000104365#ENST00000520810#Other#APH, IKKbetaNEMObind, Kdo, Pkinase, Pkinase_Tyr, Y$#ENSP00000404920#ENSG00000104365#ENST00000416505#Other#APH, IKKbetaNEMObind, Kdo, Pkinase, Pkinase_Tyr, Y$#ENSP00000427978#ENSG00000104365#ENST00000518983#Other#$#ENSP00000430868#ENSG00000104365#ENST00000520835#Other#APH, IKKbetaNEMObind, Kdo, Pkinase, Pkinase_Tyr, Y$#ENSP00000486961#ENSG00000104365#ENST00000629753#Other#APH, Kdo, Pkinase, Pkinase_Tyr, YrbL-PhoP_reg, ubi FALSE 2103 ENSG00000269335 IKBKG Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Protein binds to NFKB1 to regulate its activity IPR021063 8517 inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma [Source:HGNC Symbol;Acc: None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Laura Campitelli Arttu Jolma No $#ENSG00000269335#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IDA - PMID:15620648 | TAS - PMID:18626576, Reactom $#ENSP00000471166#ENSG00000269335#ENST00000594239#Other#CC2-LZ, NEMO$#ENSP00000479662#ENSG00000269335#ENST00000611071#Other#CC2-LZ, NEMO$#ENSP00000483825#ENSG00000269335#ENST00000618670#Other#CC2-LZ, NEMO$#ENSP00000390368#ENSG00000269335#ENST00000422680#Other#NEMO$#ENSP00000478616#ENSG00000269335#ENST00000611176#Other#Bacillus_HBL, CC2-LZ, ERM, NEMO$#ENSP00000484023#ENSG00000269335#ENST00000617207#Other#CC2-LZ, NEMO FALSE 2104 ENSG00000136634 IL10 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000098;IPR009079;IPR020423;IPR020443 3586 interleukin 10 [Source:HGNC Symbol;Acc:HGNC:5962] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Yimeng Yin Pratyush Das No $#ENSG00000136634#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:7749983 $#ENSP00000412237#ENSG00000136634#ENST00000423557#Other#IL10, IL22 FALSE 2105 ENSG00000125538 IL1B Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000975;IPR003294;IPR003502;IPR008996;IPR020877;IPR028142 3553 interleukin 1 beta [Source:HGNC Symbol;Acc:HGNC:5992] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Laura Campitelli Sam Lambert No $#ENSG00000125538#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:10748004$#ENSG00000125538#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IDA - PMID:10383454, PMID:12958148 $#ENSP00000263341#ENSG00000125538#ENST00000263341#Other#IL1, IL1_propep$#ENSP00000407219#ENSG00000125538#ENST00000418817#Other#IL1_propep$#ENSP00000409680#ENSG00000125538#ENST00000432018#Other#IL1_propep$#ENSP00000400854#ENSG00000125538#ENST00000416750#Other#IL1_propep FALSE 2106 ENSG00000196083 IL1RAP Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None None 3556 Interleukin-1 receptor accessory protein None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Laura Campitelli Pratyush Das No $#ENSG00000196083#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IEA - GO_REF:0000019 $##ENSG00000196083##Other# FALSE 2107 ENSG00000113520 IL4 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Extracellular signaling molecule. Included as a candidate only because it regulates STAT. IPR001325;IPR002354;IPR009079;IPR018096 3565 interleukin 4 [Source:HGNC Symbol;Acc:HGNC:6014] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Matt Weirauch Tim Hughes No $#ENSG00000113520#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000231449#ENSG00000113520#ENST00000231449#Other#IL4$#ENSP00000325190#ENSG00000113520#ENST00000350025#Other#IL4$#ENSP00000480581#ENSG00000113520#ENST00000622422#Other#IL4 FALSE 2108 ENSG00000113525 IL5 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None None 3567 Interleukin-5 None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Jussi Taipale Pratyush Das No $#ENSG00000113525#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019 $##ENSG00000113525##Other# FALSE 2109 ENSG00000136244 IL6 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR003573;IPR009079;IPR030473;IPR030474 3569 interleukin 6 [Source:HGNC Symbol;Acc:HGNC:6018] 4NI7 not tested not tested None Structure is with a modified DNA aptamer No No No Yes 5a, one of the source datasets predicts is as a TF Sam Lambert Matt Weirauch No $#ENSG00000136244#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:7749983$#ENSG00000136244#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IDA - PMID:12419823 $#ENSP00000258743#ENSG00000136244#ENST00000258743#Other#IL6$#ENSP00000385718#ENSG00000136244#ENST00000401651#Other#IL6$#ENSP00000385227#ENSG00000136244#ENST00000406575#Other#IL6$#ENSP00000405150#ENSG00000136244#ENST00000426291#Other#IL6$#ENSP00000385043#ENSG00000136244#ENST00000407492#Other#IL23, IL6, Phage_int_SAM_1 FALSE 2110 ENSG00000203485 INF2 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif Has a putative AT-hook None IPR003124;IPR010472;IPR010473;IPR014768;IPR015425;IPR016024 64423 inverted formin, FH2 and WH2 domain containing [Source:HGNC Symbol;Acc:HGNC:23791] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Sam Lambert Pratyush Das No None $#ENSP00000381380#ENSG00000203485#ENST00000398337#Other#Drf_FH3, Drf_GBD$#ENSP00000483829#ENSG00000203485#ENST00000617571#Other#$#ENSP00000252527#ENSG00000203485#ENST00000252527#Other#FH2, WH2 FALSE 2111 ENSG00000111653 ING4 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif Only known motifs are from Transfac or HocoMoco - origin is uncertain Interacts physically with p53 (PMID: 12750254). Transfac motif is derived from ChIP-Chip data, so unclear if it can directly bind DNA IPR001965;IPR011011;IPR019786;IPR019787;IPR024610 51147 inhibitor of growth family member 4 [Source:HGNC Symbol;Acc:HGNC:19423] None not tested not tested None None No Yes No No 2a1, Lower confidence direct evidence Tim Hughes Pratyush Das No None $#ENSP00000343396#ENSG00000111653#ENST00000341550#Other#ING, PHD, PHD_2, zf-HC5HC2H$#ENSP00000380024#ENSG00000111653#ENST00000396807#Other#ING, PHD, PHD_2, zf-HC5HC2H$#ENSP00000412705#ENSG00000111653#ENST00000412586#Other#ING, PHD, PHD_2, Spc7, zf-HC5HC2H$#ENSP00000414008#ENSG00000111653#ENST00000423703#Other#ING$#ENSP00000397343#ENSG00000111653#ENST00000444704#Other#ING, PHD, zf-HC5HC2H$#ENSP00000415903#ENSG00000111653#ENST00000446105#Other#ING, PHD, PHD_2, Spc7, zf-HC5HC2H$#ENSP00000480978#ENSG00000111653#ENST00000619641#Other#ING FALSE 2112 ENSG00000254647 INS Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR004825;IPR016179;IPR022352;IPR022353 3630 insulin [Source:HGNC Symbol;Acc:HGNC:6081] None not tested not tested None Secreted small peptide hormone No No No Yes 5a, one of the source datasets predicts is as a TF Jussi Taipale Yimeng Yin No $#ENSG00000254647#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IDA - PMID:19727662 $#ENSP00000250971#ENSG00000254647#ENST00000250971#Other#Insulin$#ENSP00000370731#ENSG00000254647#ENST00000381330#Other#Insulin$#ENSP00000380432#ENSG00000254647#ENST00000397262#Other#Insulin$#ENSP00000424008#ENSG00000254647#ENST00000512523#Other#Insulin$#ENSP00000408400#ENSG00000254647#ENST00000421783#Other#Insulin FALSE 2113 ENSG00000184216 IRAK1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000488;IPR000719;IPR001245;IPR002290;IPR008271;IPR011009;IPR011029;IPR017441 100313781 interleukin 1 receptor associated kinase 1 [Source:HGNC Symbol;Acc:HGNC:6112] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Sam Lambert Yimeng Yin No $#ENSG00000184216#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IMP - PMID:10383454$#ENSG00000184216#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IDA - PMID:10383454 | TAS - Reactome:R-HSA-445989 $#ENSP00000358991#ENSG00000184216#ENST00000369974#Other#Death, Pkinase, Pkinase_Tyr$#ENSP00000358997#ENSG00000184216#ENST00000369980#Other#Death, Pkinase, Pkinase_Tyr$#ENSP00000377291#ENSG00000184216#ENST00000393687#Other#Death, Pkinase, Pkinase_Tyr$#ENSP00000403730#ENSG00000184216#ENST00000443220#Other#APH, Pkinase, Pkinase_Tyr$#ENSP00000411809#ENSG00000184216#ENST00000455690#Other# FALSE 2114 ENSG00000134070 IRAK2 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000488;IPR000719;IPR011009;IPR011029 3656 interleukin 1 receptor associated kinase 2 [Source:HGNC Symbol;Acc:HGNC:6113] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Yimeng Yin Pratyush Das No $#ENSG00000134070#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IMP - PMID:10383454$#ENSG00000134070#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IMP - PMID:10383454 | TAS - Reactome:R-HSA-445989 $#ENSP00000256458#ENSG00000134070#ENST00000256458#Other#Death, Pkinase, Pkinase_Tyr FALSE 2115 ENSG00000090376 IRAK3 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000488;IPR000719;IPR011009;IPR011029 102465249 interleukin 1 receptor associated kinase 3 [Source:HGNC Symbol;Acc:HGNC:17020] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Jussi Taipale Laura Campitelli No $#ENSG00000090376#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IMP - PMID:10383454, PMID:18156187$#ENSG00000090376#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IMP - PMID:10383454 $#ENSP00000261233#ENSG00000090376#ENST00000261233#Other#Death, Pkinase, Pkinase_Tyr$#ENSP00000441321#ENSG00000090376#ENST00000545837#Other#$#ENSP00000409852#ENSG00000090376#ENST00000457197#Other#FTA2, Pkinase, Pkinase_Tyr FALSE 2116 ENSG00000170604 IRF2BP1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR018957;IPR022750 26145 interferon regulatory factor 2 binding protein 1 [Source:HGNC Symbol;Acc:HGNC:21728] None not tested not tested None PMID: 18671972, supposed to be an ubiquitin ligase that associates with IRF2 and ubiquitinylates JDP2 (a Cre element binding bZIP), so it is likely a non-DNA binding corepressor No No TF Gene Candidate__Co-activation_PMIDS:12799427 No 5a, one of the source datasets predicts is as a TF Yimeng Yin Laura Campitelli No None $##ENSG00000170604##Other# FALSE 2117 ENSG00000078747 ITCH Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000008;IPR000569;IPR001202;IPR024928 83737 itchy E3 ubiquitin protein ligase [Source:HGNC Symbol;Acc:HGNC:13890] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Laura Campitelli Tim Hughes No $#ENSG00000078747#GO:0032088#negative regulation of NF-kappaB transcription factor activity#ISS - GO_REF:0000024 $#ENSP00000262650#ENSG00000078747#ENST00000262650#Other#C2, HECT, WW$#ENSP00000363998#ENSG00000078747#ENST00000374864#Other#C2, HECT, WW FALSE 2118 ENSG00000160255 ITGB2 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None None 3689 Integrin beta-2 None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Sam Lambert Pratyush Das No $#ENSG00000160255#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IEA - GO_REF:0000019 $##ENSG00000160255##Other# FALSE 2119 ENSG00000142856 ITGB3BP Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR009601 23421 integrin subunit beta 3 binding protein [Source:HGNC Symbol;Acc:HGNC:6157] None not tested not tested None None No No TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:10490654 No 5a, one of the source datasets predicts is as a TF Sam Lambert Pratyush Das No None $##ENSG00000142856##Other# FALSE 2120 ENSG00000161652 IZUMO2 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None IZUMO is not considered to be a DNA-binding domain IPR029389 126123 IZUMO family member 2 [Source:HGNC Symbol;Acc:HGNC:28518];Izumo sperm-egg fusion protein 2 None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Yimeng Yin Sam Lambert No $#ENSG00000161652#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000293405#ENSG00000161652#ENST00000293405#Other#IZUMO$#ENSP00000472657#ENSG00000161652#ENST00000600293#Other#IZUMO FALSE 2121 ENSG00000077684 JADE1 Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None FYVE and PHD zinc fingers are unlikely to specifically-bind DNA IPR001965;IPR011011;IPR019542;IPR019786;IPR019787 79960 jade family PHD finger 1 [Source:HGNC Symbol;Acc:HGNC:30027] None not tested not tested None None No No TF Gene Candidate_Transcription Regulatory Activity: heterochromatin interaction/binding_Other; Transactivation_PMIDS:15502158 No 5a, one of the source datasets predicts is as a TF Pratyush Das Sam Lambert No None $##ENSG00000077684##Other# FALSE 2122 ENSG00000096968 JAK2 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None This is JAK from the classic JAK-STAT pathway. It is included only because GO lists it under positive regulation of sequence-specific DNA binding transcription factor activity. No evidence of sequence specificity - the STATs handle that. None 3717 Tyrosine-protein kinase JAK2 None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Pratyush Das Tim Hughes No $#ENSG00000096968#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019 $##ENSG00000096968##Other# FALSE 2123 ENSG00000152409 JMY Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Coactivator protein that associates with p300 and TP53 (PMID: 10518217). There is no evidence that it contacts DNA itself. Functions also in actin nucleation (PMID: 19287377). IPR003124 133746 junction mediating and regulatory protein, p53 cofactor [Source:HGNC Symbol;Acc:HGNC:28916];Junction None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Sam Lambert Arttu Jolma No $#ENSG00000152409#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024 $#ENSP00000379441#ENSG00000152409#ENST00000396137#Other#JMY, WH2, WHAMM-JMY_N FALSE 2124 ENSG00000173801 JUP Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000225;IPR013284;IPR016024 3728 junction plakoglobin [Source:HGNC Symbol;Acc:HGNC:6207] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Sam Lambert Laura Campitelli No $#ENSG00000173801#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:14661054 $#ENSP00000311113#ENSG00000173801#ENST00000310706#Other#Adaptin_N, Arm, Arm_2, Atx10homo_assoc, Cnd1, DUF3$#ENSP00000377508#ENSG00000173801#ENST00000393931#Other#Adaptin_N, Arm, Arm_2, Atx10homo_assoc, Cnd1, DUF3$#ENSP00000411449#ENSG00000173801#ENST00000420370#Other#Adaptin_N, Arm, Cnd1, HEAT, HEAT_2, HEAT_EZ$#ENSP00000401034#ENSG00000173801#ENST00000424457#Other#Adaptin_N, Arm, Cnd1, HEAT_2$#ENSP00000394146#ENSG00000173801#ENST00000437187#Other#Adaptin_N, Arm, Cnd1, HEAT, HEAT_2, HEAT_EZ$#ENSP00000409948#ENSG00000173801#ENST00000437369#Other#$#ENSP00000389886#ENSG00000173801#ENST00000449889#Other#Adaptin_N, Arm, Cnd1, HEAT, HEAT_2, HEAT_EZ$#ENSP00000468347#ENSG00000173801#ENST00000591690#Other# FALSE 2125 ENSG00000139620 KANSL2 Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None Protein is a component of the NSL chromatin remodelling complex IPR025927 54934 KAT8 regulatory NSL complex subunit 2 [Source:HGNC Symbol;Acc:HGNC:26024] None not tested not tested None None No Yes No No 5a, one of the source datasets predicts is as a TF Arttu Jolma Matt Weirauch No None $#ENSP00000415436#ENSG00000139620#ENST00000420613#Other#zf-C3Hc3H$#ENSP00000449747#ENSG00000139620#ENST00000550347#Other#zf-C3Hc3H$#ENSP00000447608#ENSG00000139620#ENST00000547087#Other#zf-C3Hc3H$#ENSP00000446493#ENSG00000139620#ENST00000548304#Other#zf-C3Hc3H FALSE 2126 ENSG00000108773 KAT2A Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Histone deacetylase IPR000182;IPR001487;IPR009464;IPR016181;IPR016376;IPR018359 2648 lysine acetyltransferase 2A [Source:HGNC Symbol;Acc:HGNC:4201] None not tested not tested None None No No TF Gene_Transcription Regulatory Activity: heterochromatin interaction/binding_Transactivation_PMIDS:8552087;8972232;10611234 No 5a, one of the source datasets predicts is as a TF Jussi Taipale Yimeng Yin No None $##ENSG00000108773##Other# FALSE 2127 ENSG00000114166 KAT2B Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Interacts with TFs to modify histones (PMID: 9707565) IPR000182;IPR001487;IPR009464;IPR016181;IPR016376;IPR018359 8850 lysine acetyltransferase 2B [Source:HGNC Symbol;Acc:HGNC:8638] None not tested not tested None None No No TF Gene Candidate_Transcription Factor Binding: tf co-factor binding; Transcription Regulatory Activity: heterochromatin interaction/binding_TF PPI_PMIDS:8684459 No 5a, one of the source datasets predicts is as a TF Laura Campitelli Arttu Jolma No None $##ENSG00000114166##Other# FALSE 2128 ENSG00000172977 KAT5 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Histone acetyltransferase IPR000953;IPR002717;IPR016181;IPR016197;IPR025995; 10524 lysine acetyltransferase 5 [Source:HGNC Symbol;Acc:HGNC:5275] None Full not tested None None x No TF Gene Candidate__Co-activation_PMIDS:8607265 No 4a, two or more datasets predict it as a TF Arttu Jolma Jussi Taipale Yes None $#ENSP00000340330#ENSG00000172977#ENST00000341318#Other#Acetyltransf_7, MOZ_SAS, Tudor-knot$#ENSP00000344955#ENSG00000172977#ENST00000352980#Other#Acetyltransf_1, Acetyltransf_7, MOZ_SAS, Tudor-kno$#ENSP00000366245#ENSG00000172977#ENST00000377046#Other#Acetyltransf_1, Acetyltransf_7, MOZ_SAS, Tudor-kno$#ENSP00000434765#ENSG00000172977#ENST00000530446#Other#Acetyltransf_1, Acetyltransf_7, MOZ_SAS, Tudor-kno$#ENSP00000431819#ENSG00000172977#ENST00000534650#Other#Acetyltransf_1, Acetyltransf_7, MOZ_SAS$#ENSP00000434993#ENSG00000172977#ENST00000534681#Other#$#ENSP00000436247#ENSG00000172977#ENST00000530605#Other#Tudor-knot$#ENSP00000436012#ENSG00000172977#ENST00000531880#Other#Tudor-knot$#ENSP00000435766#ENSG00000172977#ENST00000533596#Other#MOZ_SAS FALSE 2129 ENSG00000083168 KAT6A Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Histone deacetylase; likely a transcriptional cofactor IPR001965;IPR002717;IPR005818;IPR011011;IPR016181;IPR019787 7994 lysine acetyltransferase 6A [Source:HGNC Symbol;Acc:HGNC:13013] None not tested not tested None None x No TF Gene_Transcription Factor Binding: tf co-factor binding_Co-activation; TF PPI_PMIDS:16702405 No 4a, two or more datasets predict it as a TF Matt Weirauch Arttu Jolma Yes None $#ENSP00000265713#ENSG00000083168#ENST00000265713#Other#Acetyltransf_7, Linker_histone, MOZ_SAS, PHD, PHD_$#ENSP00000430606#ENSG00000083168#ENST00000485568#Other#Acetyltransf_7, Linker_histone, MOZ_SAS, PHD, PHD_$#ENSP00000399638#ENSG00000083168#ENST00000418721#Other#Acetyltransf_7, MOZ_SAS$#ENSP00000396699#ENSG00000083168#ENST00000426524#Other# FALSE 2130 ENSG00000156650 KAT6B Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Co-factor. Could possibly bind to DNA, as a helix- turn-helix DNA-binding motif is present within its MYST-type HAT domain. IPR001965;IPR002717;IPR005818;IPR011011;IPR016181;IPR019787 23522 lysine acetyltransferase 6B [Source:HGNC Symbol;Acc:HGNC:17582] None Full not tested None None x No No No 5a, one of the source datasets predicts is as a TF Sam Lambert Yimeng Yin Yes None $#ENSP00000287239#ENSG00000156650#ENST00000287239#Other#Acetyltransf_7, Linker_histone, MOZ_SAS, PHD$#ENSP00000361796#ENSG00000156650#ENST00000372711#Other#Acetyltransf_7, Linker_histone, MOZ_SAS, PHD FALSE 2131 ENSG00000103510 KAT8 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None No DBDs, no evidence of TF activity - looks like a chromatin protein. Included only because it has an x in Vaquerizas 2009. IPR000953;IPR002717;IPR016181;IPR016197;IPR025995; 84148 lysine acetyltransferase 8 [Source:HGNC Symbol;Acc:HGNC:17933] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Tim Hughes Yimeng Yin Yes None $#ENSP00000219797#ENSG00000103510#ENST00000219797#Other#Acetyltransf_7, MOZ_SAS, Myosin_head, Tudor-knot$#ENSP00000406037#ENSG00000103510#ENST00000448516#Other#Acetyltransf_7, MOZ_SAS, Myosin_head, Tudor-knot$#ENSP00000454592#ENSG00000103510#ENST00000537402#Other#Acetyltransf_7, MOZ_SAS$#ENSP00000456933#ENSG00000103510#ENST00000543774#Other#Acetyltransf_7, MOZ_SAS, Myosin_head, Tudor-knot FALSE 2132 ENSG00000115041 KCNIP3 Unknown Yes Likely to be sequence specific TF Monomer or homomultimer No motif None There are multiple papers showing DREAM can bind DNA (PMID: 10078534, PMID: 11108959). IPR002048;IPR011992;IPR018247 30818 potassium voltage-gated channel interacting protein 3 [Source:HGNC Symbol;Acc:HGNC:15523] None not tested not tested None None No No TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:10078534 No 5a, one of the source datasets predicts is as a TF Jussi Taipale Matt Weirauch No None $##ENSG00000115041##Other# FALSE 2133 ENSG00000004487 KDM1A Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None Affects transcription by histone modification IPR002937;IPR007526;IPR009057;IPR017366 23028 lysine demethylase 1A [Source:HGNC Symbol;Acc:HGNC:29079] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Pratyush Das Laura Campitelli No $#ENSG00000004487#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019$#ENSG00000004487#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:19497860 | IMP - PMID:17805299$#ENSG00000004487#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:20833138 $#ENSP00000349049#ENSG00000004487#ENST00000356634#Other#AlaDh_PNT_C, Amino_oxidase, DAO, FAD_binding_2, FA$#ENSP00000383042#ENSG00000004487#ENST00000400181#Other#AlaDh_PNT_C, Amino_oxidase, DAO, FAD_binding_2, FA$#ENSP00000473294#ENSG00000004487#ENST00000494920#Other#Amino_oxidase$#ENSP00000473297#ENSG00000004487#ENST00000465864#Other#Amino_oxidase FALSE 2134 ENSG00000115548 KDM3A Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Its a C6 zinc finger and Jumonji-type protein. No DBD. None 55818 Lysine-specific demethylase 3A None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Tim Hughes Matt Weirauch No $#ENSG00000115548#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019 $##ENSG00000115548##Other# FALSE 2135 ENSG00000079999 KEAP1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000210;IPR006652;IPR011333;IPR011705;IPR013069;IPR017096 9817 kelch like ECH associated protein 1 [Source:HGNC Symbol;Acc:HGNC:23177] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Matt Weirauch Pratyush Das No $#ENSG00000079999#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#TAS - PMID:17015834 $#ENSP00000171111#ENSG00000079999#ENST00000171111#Other#BACK, BTB, Kelch_1, Kelch_2, Kelch_3, Kelch_4, Kel$#ENSP00000377245#ENSG00000079999#ENST00000393623#Other#BACK, BTB, Kelch_1, Kelch_2, Kelch_3, Kelch_4, Kel$#ENSP00000468014#ENSG00000079999#ENST00000592478#Other#Kelch_1, Kelch_2, Kelch_3, Kelch_4, Kelch_6$#ENSP00000465024#ENSG00000079999#ENST00000591039#Other#BACK, BTB$#ENSP00000465126#ENSG00000079999#ENST00000591419#Other#BACK, BTB$#ENSP00000468671#ENSG00000079999#ENST00000592055#Other#BACK, BTB FALSE 2136 ENSG00000122778 KIAA1549 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR024606; 57670 KIAA1549 [Source:HGNC Symbol;Acc:HGNC:22219] None not tested not tested None None c No No No 5a, one of the source datasets predicts is as a TF Laura Campitelli Pratyush Das No None $#ENSP00000416040#ENSG00000122778#ENST00000422774#Other#DUF3827$#ENSP00000406661#ENSG00000122778#ENST00000440172#Other#DUF3827 FALSE 2137 ENSG00000130518 KIAA1683 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None No evidence to support a DNA binding function IPR000048;IPR027417 80726 KIAA1683 [Source:HGNC Symbol;Acc:HGNC:29350] None Full not tested None None x No No No 5a, one of the source datasets predicts is as a TF Arttu Jolma Laura Campitelli No None $#ENSP00000376213#ENSG00000130518#ENST00000392413#Other#IQ$#ENSP00000470780#ENSG00000130518#ENST00000600328#Other#IQ$#ENSP00000472912#ENSG00000130518#ENST00000600359#Other#IQ FALSE 2138 ENSG00000165185 KIAA1958 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR021893 158405 KIAA1958 [Source:HGNC Symbol;Acc:HGNC:23427];Uncharacterized protein KIAA1958 None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Yimeng Yin Laura Campitelli No $#ENSG00000165185#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000336940#ENSG00000165185#ENST00000337530#Other#DUF3504$#ENSP00000440504#ENSG00000165185#ENST00000536272#Other#DUF3504$#ENSP00000363362#ENSG00000165185#ENST00000374244#Other#DUF3504 FALSE 2139 ENSG00000157404 KIT Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000719;IPR001245;IPR001824;IPR003598;IPR003599;IPR007110;IPR008266;IPR011009;IPR013151;IPR016243;IPR017441; 3815 KIT proto-oncogene receptor tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:6342];Mast/stem cell growth None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Jussi Taipale Laura Campitelli No $#ENSG00000157404#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IMP - PMID:21135090 $#ENSP00000288135#ENSG00000157404#ENST00000288135#Other#I-set, Ig_2, Ig_3, Ig_4, Ig_5, Pkinase, Pkinase_Ty$#ENSP00000390987#ENSG00000157404#ENST00000412167#Other#I-set, Ig_2, Ig_3, Ig_4, Ig_5, Pkinase, Pkinase_Ty FALSE 2140 ENSG00000184445 KNTC1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Rod_C domain localizes to kinetochores but has not been shown to be DNA-binding IPR017986;IPR019527 9735 kinetochore associated 1 [Source:HGNC Symbol;Acc:HGNC:17255] None Full not tested None None x No No No 5a, one of the source datasets predicts is as a TF Sam Lambert Arttu Jolma No None $#ENSP00000328236#ENSG00000184445#ENST00000333479#Other#Rod_C$#ENSP00000408760#ENSG00000184445#ENST00000436959#Other#MRP-S22, Rod_C$#ENSP00000397992#ENSG00000184445#ENST00000450485#Other#Rod_C$#ENSP00000437344#ENSG00000184445#ENST00000534995#Other#MRP-S22, Rod_C FALSE 2141 ENSG00000133703 KRAS Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None None 3845 GTPase KRas None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Matt Weirauch Pratyush Das No $#ENSG00000133703#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IEA - GO_REF:0000019 $##ENSG00000133703##Other# FALSE 2142 ENSG00000240747 KRBOX1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None KRAB domain only - no DBD or evidence for independent DNA binding IPR001909 100506243 KRAB box domain containing 1 [Source:HGNC Symbol;Acc:HGNC:38708] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Yimeng Yin Jussi Taipale No $#ENSG00000240747#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000373254#ENSG00000240747#ENST00000383748#Other#KRAB$#ENSP00000388094#ENSG00000240747#ENST00000418176#Other#KRAB$#ENSP00000413859#ENSG00000240747#ENST00000426937#Other#KRAB FALSE 2143 ENSG00000205869 KRTAP5-1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None None 387264 keratin associated protein 5-1 [Source:HGNC Symbol;Acc:HGNC:23596] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Sam Lambert Arttu Jolma No None $#ENSP00000371606#ENSG00000205869#ENST00000382171#Other# FALSE 2144 ENSG00000254997 KRTAP5-9 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None None 3846 keratin associated protein 5-9 [Source:HGNC Symbol;Acc:HGNC:23604] None Full not tested None None x No No No 5a, one of the source datasets predicts is as a TF Pratyush Das Sam Lambert No None $#ENSP00000431443#ENSG00000254997#ENST00000528743#Other# FALSE 2145 ENSG00000198083 KRTAP9-9 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Keratin-associated protein IPR002494; 81870 keratin associated protein 9-9 [Source:HGNC Symbol;Acc:HGNC:16773] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Pratyush Das Laura Campitelli No None $#ENSP00000377576#ENSG00000198083#ENST00000394008#Other#Keratin_B2, Keratin_B2_2 FALSE 2146 ENSG00000155506 LARP1 Unknown No ssDNA/RNA binding Not a DNA binding protein No motif None Classic RNA binding protein IPR006607;IPR006630 23367 La ribonucleoprotein domain family member 1 [Source:HGNC Symbol;Acc:HGNC:29531] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Yimeng Yin Arttu Jolma No None $#ENSP00000336721#ENSG00000155506#ENST00000336314#Other#La$#ENSP00000429624#ENSG00000155506#ENST00000518892#Other#$#ENSP00000430169#ENSG00000155506#ENST00000522272#Other#$#ENSP00000429710#ENSG00000155506#ENST00000519931#Other# FALSE 2147 ENSG00000138709 LARP1B Unknown No ssDNA/RNA binding Not a DNA binding protein No motif None None IPR006607;IPR006630 55132 La ribonucleoprotein domain family member 1B [Source:HGNC Symbol;Acc:HGNC:24704] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Laura Campitelli Pratyush Das No None $#ENSP00000377829#ENSG00000138709#ENST00000394288#Other#La$#ENSP00000390395#ENSG00000138709#ENST00000432347#Other#La$#ENSP00000422850#ENSG00000138709#ENST00000512292#Other#La$#ENSP00000424383#ENSG00000138709#ENST00000507377#Other#La FALSE 2148 ENSG00000161813 LARP4 Unknown No ssDNA/RNA binding Not a DNA binding protein No motif None Classic RNA binding protein IPR006630; 113251 La ribonucleoprotein domain family member 4 [Source:HGNC Symbol;Acc:HGNC:24320] None Full Yes None None x No No No 5a, one of the source datasets predicts is as a TF Sam Lambert Matt Weirauch No None $#ENSP00000293618#ENSG00000161813#ENST00000293618#Other#La$#ENSP00000340901#ENSG00000161813#ENST00000347328#Other#La$#ENSP00000381490#ENSG00000161813#ENST00000398473#Other#La$#ENSP00000429077#ENSG00000161813#ENST00000518444#Other#La$#ENSP00000430851#ENSG00000161813#ENST00000518561#Other#La$#ENSP00000429781#ENSG00000161813#ENST00000522085#Other#La$#ENSP00000447408#ENSG00000161813#ENST00000551886#Other#La$#ENSP00000430551#ENSG00000161813#ENST00000523389#Other#$#ENSP00000446540#ENSG00000161813#ENST00000548174#Other#$#ENSP00000448756#ENSG00000161813#ENST00000550260#Other#La$#ENSP00000447397#ENSG00000161813#ENST00000552445#Other# FALSE 2149 ENSG00000107929 LARP4B Unknown No ssDNA/RNA binding Not a DNA binding protein No motif None Classic RNA binding protein IPR006630; 23185 La ribonucleoprotein domain family member 4B [Source:HGNC Symbol;Acc:HGNC:28987] None Full not tested None None x No No No 5a, one of the source datasets predicts is as a TF Jussi Taipale Sam Lambert No None $#ENSP00000326128#ENSG00000107929#ENST00000316157#Other#La$#ENSP00000403018#ENSG00000107929#ENST00000440895#Other#$#ENSP00000390556#ENSG00000107929#ENST00000412411#Other# FALSE 2150 ENSG00000166173 LARP6 Unknown No ssDNA/RNA binding Not a DNA binding protein No motif None Classic RNA binding protein IPR002344;IPR006630;IPR024642; 55323 La ribonucleoprotein domain family member 6 [Source:HGNC Symbol;Acc:HGNC:24012] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Jussi Taipale Matt Weirauch No None $#ENSP00000299213#ENSG00000166173#ENST00000299213#Other#La, SUZ-C$#ENSP00000343869#ENSG00000166173#ENST00000344870#Other#$#ENSP00000453551#ENSG00000166173#ENST00000559140#Other#$#ENSP00000467334#ENSG00000166173#ENST00000559316#Other# FALSE 2151 ENSG00000174720 LARP7 Unknown No ssDNA/RNA binding Not a DNA binding protein No motif None Classic RNA binding protein IPR000504;IPR002344;IPR006630;IPR014886 51574 La ribonucleoprotein domain family member 7 [Source:HGNC Symbol;Acc:HGNC:24912] None Full not tested None None x No No No 5a, one of the source datasets predicts is as a TF Sam Lambert Jussi Taipale No None $#ENSP00000422626#ENSG00000174720#ENST00000509061#Other#La, RRM_3$#ENSP00000344950#ENSG00000174720#ENST00000344442#Other#La, RRM_3$#ENSP00000421541#ENSG00000174720#ENST00000505034#Other#La$#ENSP00000422013#ENSG00000174720#ENST00000513553#Other#RRM_3 FALSE 2152 ENSG00000168961 LGALS9 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR001079;IPR013320 3965 galectin 9 [Source:HGNC Symbol;Acc:HGNC:6570] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Matt Weirauch Sam Lambert No $#ENSG00000168961#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IMP - PMID:25754930 $#ENSP00000306228#ENSG00000168961#ENST00000302228#Other#Gal-bind_lectin$#ENSP00000378856#ENSG00000168961#ENST00000395473#Other#Gal-bind_lectin$#ENSP00000462382#ENSG00000168961#ENST00000581710#Other#Gal-bind_lectin$#ENSP00000318214#ENSG00000168961#ENST00000313648#Other#Gal-bind_lectin$#ENSP00000462359#ENSG00000168961#ENST00000577392#Other#Gal-bind_lectin$#ENSP00000464581#ENSG00000168961#ENST00000578944#Other#Gal-bind_lectin FALSE 2153 ENSG00000205213 LGR4 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000276;IPR000372;IPR001611;IPR002131;IPR003591;IPR017452;IPR025875; 55366 leucine rich repeat containing G protein-coupled receptor 4 [Source:HGNC Symbol;Acc:HGNC:13299] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Laura Campitelli Pratyush Das No None $#ENSP00000368516#ENSG00000205213#ENST00000379214#Other#7tm_1, DUF3557, LRRNT, LRR_1, LRR_4, LRR_5, LRR_8,$#ENSP00000374508#ENSG00000205213#ENST00000389858#Other#7tm_1, LRRNT, LRR_1, LRR_4, LRR_5, LRR_8, LRR_9$#ENSP00000431650#ENSG00000205213#ENST00000480977#Other#LRRNT, LRR_1, LRR_4, LRR_5, LRR_8, LRR_9 FALSE 2154 ENSG00000105486 LIG1 Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None DNA ligase. Binds DNA in the crystal structure (PDB: 1X9N) None None DNA ligase 1 1X9N not tested not tested None DNA ligase. Binds DNA in the crystal structure (PDB: 1X9N) No No No No New proteins added based on PDB entry Arttu Jolma Sam Lambert No None None FALSE 2155 ENSG00000005156 LIG3 Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None DNA ligase. Binds DNA in the crystal structure (PDB: 3L2P) None None DNA ligase 3 3L2P not tested not tested None DNA ligase. Binds DNA in the crystal structure (PDB: 3L2P) No No No No New proteins added based on PDB entry Arttu Jolma Sam Lambert No None None FALSE 2156 ENSG00000135363 LMO2 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif Only known motifs are from Transfac or HocoMoco - origin is uncertain Protein binds to bHLH TFs, which then bind to DNA (PMID: 9707419). Both transfac motifs are suspect - the bHLH motif likely resulted from an indirect interaction. IPR001781 4005 LIM domain only 2 [Source:HGNC Symbol;Acc:HGNC:6642] 2YPA not tested not tested None LMO2 does not contact the DNA in the structure but contacts TAL1 and TCF3 No Yes No Yes 2a1, Lower confidence direct evidence Arttu Jolma Tim Hughes No $#ENSG00000135363#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IDA - PMID:16314316$#ENSG00000135363#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IDA - PMID:16314316 $#ENSP00000257818#ENSG00000135363#ENST00000257818#Other#LIM$#ENSP00000379175#ENSG00000135363#ENST00000395833#Other#LIM FALSE 2157 ENSG00000143013 LMO4 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR001781 8543 LIM domain only 4 [Source:HGNC Symbol;Acc:HGNC:6644] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Matt Weirauch Sam Lambert No $#ENSG00000143013#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:10209267 $#ENSP00000359573#ENSG00000143013#ENST00000370542#Other#LIM$#ENSP00000359575#ENSG00000143013#ENST00000370544#Other#LIM FALSE 2158 ENSG00000145012 LPP Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None znfLIM is probably not a DNA binding domain (PMID: 8506279). The protein has been reported to be coactivator for ETV4 (PMID: 16738319). IPR001781 4026 LIM domain containing preferred translocation partner in lipoma [Source:HGNC Symbol;Acc:HGNC:6679] None not tested not tested None None No No TF Gene_Transcription Factor Binding: tf co-factor binding_Co-activation_PMIDS:16738319 No 5a, one of the source datasets predicts is as a TF Yimeng Yin Arttu Jolma No None $##ENSG00000145012##Other# FALSE 2159 ENSG00000162337 LRP5 Unknown No ssDNA/RNA binding Not a DNA binding protein No motif None None None 4041 Low-density lipoprotein receptor-related protein 5 None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Pratyush Das Yimeng Yin No $#ENSG00000162337#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019 $##ENSG00000162337##Other# FALSE 2160 ENSG00000070018 LRP6 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Cell surface receptor that is in the beginning of the WNT signaling cascade. GO annotation has no evidence of DNA-binding activity (PMID: 14739301). IPR000033;IPR000742;IPR002172;IPR017049;IPR023415 4040 LDL receptor related protein 6 [Source:HGNC Symbol;Acc:HGNC:6698];Low-density lipoprotein receptor-r None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Arttu Jolma Sam Lambert No $#ENSG00000070018#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:14739301 $#ENSP00000261349#ENSG00000070018#ENST00000261349#Other#DUF5050, FXa_inhibition, Ldl_recept_a, Ldl_recept_$#ENSP00000442472#ENSG00000070018#ENST00000543091#Other#DUF5050, FXa_inhibition, Ldl_recept_a, Ldl_recept_$#ENSP00000439765#ENSG00000070018#ENST00000535731#Other#Ldl_recept_b, SGL$#ENSP00000443239#ENSG00000070018#ENST00000540527#Other#Ldl_recept_a FALSE 2161 ENSG00000157193 LRP8 Unknown No ssDNA/RNA binding Not a DNA binding protein No motif None None IPR000033;IPR000152;IPR000742;IPR001881;IPR002172;IPR009030;IPR013032;IPR018097;IPR023415 7804 LDL receptor related protein 8 [Source:HGNC Symbol;Acc:HGNC:6700] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Pratyush Das Jussi Taipale No $#ENSG00000157193#GO:0032793#positive regulation of CREB transcription factor activity#ISS - GO_REF:0000024 $#ENSP00000303634#ENSG00000157193#ENST00000306052#Other#DUF5050, EGF_CA, FXa_inhibition, Ldl_recept_a, Ldl$#ENSP00000346391#ENSG00000157193#ENST00000354412#Other#DUF5050, EGF_CA, FXa_inhibition, Ldl_recept_a, Ldl$#ENSP00000360509#ENSG00000157193#ENST00000371454#Other#DUF5050, EGF_CA, FXa_inhibition, Ldl_recept_a, Ldl$#ENSP00000437009#ENSG00000157193#ENST00000465675#Other#DUF5050, FXa_inhibition, Ldl_recept_b, NHL, SGL, S$#ENSP00000436651#ENSG00000157193#ENST00000475501#Other#EGF, EGF_3, EGF_CA, FXa_inhibition, Ldl_recept_b, FALSE 2162 ENSG00000124831 LRRFIP1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Seems to be included only because GO catalogs positive regulation of NF-kappaB transcription factor activity. Nothing that would indicate DNA binding. None 9208 Leucine-rich repeat flightless-interacting protein 1 None not tested Yes None None No No No Yes 5a, one of the source datasets predicts is as a TF Tim Hughes Matt Weirauch Yes $#ENSG00000124831#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IEA - GO_REF:0000019 $##ENSG00000124831##Other# FALSE 2163 ENSG00000093167 LRRFIP2 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Its paralog forms a complex with ETS1 that binds AGCCCCCGGCG sequences based on EMSA and SPR (PMID: 16199883). However, direct DNA binding by LRRFIP2 is not demonstrated, and it seems more likely that it is in the complex through protein-protein interactions. None None Leucine-rich repeat flightless-interacting protein 2 None not tested not tested None Its paralog forms a complex with ETS1 that binds AGCCCCCGGCG sequences based on EMSA and SPR (PMID: 16199883). However, direct DNA binding by LRRFIP2 is not demonstrated, and it seems more likely that it is in the complex through protein-protein interactions. No No No No New proteins added after initial stage Arttu Jolma Sam Lambert Yes None None FALSE 2164 ENSG00000105699 LSR Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Cell plasma membrane resident protein that functions in cell-cell junctions (PMID: 25753034) IPR003599;IPR007110;IPR008664 51599 lipolysis stimulated lipoprotein receptor [Source:HGNC Symbol;Acc:HGNC:29572] None not tested not tested None None No No Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0 No 5a, one of the source datasets predicts is as a TF Matt Weirauch Arttu Jolma No None $##ENSG00000105699##Other# FALSE 2165 ENSG00000012223 LTF Unknown Yes Known motif Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain None IPR001156;IPR016357;IPR018195;IPR030684 4057 lactotransferrin [Source:HGNC Symbol;Acc:HGNC:6720] None not tested not tested None None No Yes No Yes 2a1, Lower confidence direct evidence Arttu Jolma Matt Weirauch No $#ENSG00000012223#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IDA - PMID:20345905 $#ENSP00000231751#ENSG00000012223#ENST00000231751#Other#Phosphonate-bd, Transferrin$#ENSP00000405546#ENSG00000012223#ENST00000417439#Other#Phosphonate-bd, Transferrin$#ENSP00000405719#ENSG00000012223#ENST00000426532#Other#Phosphonate-bd, Transferrin$#ENSP00000397427#ENSG00000012223#ENST00000443496#Other#Phosphonate-bd, Transferrin FALSE 2166 ENSG00000198862 LTN1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR001841;IPR011016;IPR016024; 26046 listerin E3 ubiquitin protein ligase 1 [Source:HGNC Symbol;Acc:HGNC:13082] None DBD not tested None None a No No No 5a, one of the source datasets predicts is as a TF Laura Campitelli Pratyush Das No None $#ENSP00000354977#ENSG00000198862#ENST00000361371#Other#FANCL_C, RINGv, zf-ANAPC11, zf-RING_2, zf-rbx1$#ENSP00000373846#ENSG00000198862#ENST00000389194#Other#FANCL_C, RINGv, zf-ANAPC11, zf-RING_2, zf-rbx1$#ENSP00000373847#ENSG00000198862#ENST00000389195#Other#$#ENSP00000478783#ENSG00000198862#ENST00000614971#Other#FANCL_C, RINGv, zf-ANAPC11, zf-RING_2, zf-rbx1 FALSE 2167 ENSG00000163818 LZTFL1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Lactotransferrin - major iron-binding protein in milk. Two papers from the 1990s (PMID: 7854459; PMID: 1037119) demonstrate strong DNA binding. None 54585 leucine zipper transcription factor like 1 [Source:HGNC Symbol;Acc:HGNC:6741] None not tested not tested None None No No Indeterminate - There is no evidence for or against this genes role as a TF__Other_PMIDS:11352561 No 5a, one of the source datasets predicts is as a TF Pratyush Das Arttu Jolma No None $##ENSG00000163818##Other# FALSE 2168 ENSG00000099949 LZTR1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000210;IPR006652;IPR011333;IPR013069 8216 leucine-zipper-like transcription regulator 1 [Source:HGNC Symbol;Acc:HGNC:6742] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Jussi Taipale Tim Hughes No $#ENSG00000099949#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:7633402 $#ENSP00000215739#ENSG00000099949#ENST00000215739#Other#BACK, BTB, Kelch_1, Kelch_2, Kelch_3, Kelch_4, Kel$#ENSP00000397252#ENSG00000099949#ENST00000415817#Other#BTB FALSE 2169 ENSG00000061337 LZTS1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Does not contain a bZIP domain. (PMID: 10097140) does not examine TF activity or DNA binding - GO needs to be corrected. IPR033293 11178 leucine zipper, putative tumor suppressor 1 [Source:HGNC Symbol;Acc:HGNC:13861] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Tim Hughes Matt Weirauch No $#ENSG00000061337#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:10097140 $#ENSP00000265801#ENSG00000061337#ENST00000265801#Other#Fez1$#ENSP00000429263#ENSG00000061337#ENST00000522290#Other#Fez1$#ENSP00000479534#ENSG00000061337#ENST00000616228#Other#$#ENSP00000370981#ENSG00000061337#ENST00000381569#Other#Fez1 FALSE 2170 ENSG00000183742 MACC1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR011511; 346389 metastasis associated in colon cancer 1 [Source:HGNC Symbol;Acc:HGNC:30215] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Pratyush Das Arttu Jolma No None $#ENSP00000328410#ENSG00000183742#ENST00000332878#Other#Death, SH3_2, ZU5$#ENSP00000383185#ENSG00000183742#ENST00000400331#Other#Death, SH3_2, ZU5$#ENSP00000466864#ENSG00000183742#ENST00000589011#Other#Death, SH3_2, ZU5 FALSE 2171 ENSG00000127603 MACF1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Included only because Vasquerizas 2009 includes it with an x. No DBD and no other data to support being a TF. IPR001101;IPR001589;IPR001715;IPR002017;IPR002048;IPR003108;IPR011992;IPR018159;IPR018247; 643314 microtubule-actin crosslinking factor 1 [Source:HGNC Symbol;Acc:HGNC:13664] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Sam Lambert Tim Hughes No None $#ENSP00000434859#ENSG00000127603#ENST00000484793#Other#$#ENSP00000473615#ENSG00000127603#ENST00000602421#Other#$#ENSP00000435892#ENSG00000127603#ENST00000494012#Other#CH$#ENSP00000431179#ENSG00000127603#ENST00000530275#Other# FALSE 2172 ENSG00000116670 MAD2L2 Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None Likely to be a DNA-binding protein that operates on DNA-repair (PMID: 25799990) IPR003511 10459 MAD2 mitotic arrest deficient-like 2 (yeast) [Source:HGNC Symbol;Acc:HGNC:6764] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Arttu Jolma Pratyush Das No $#ENSG00000116670#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:19443654 $#ENSP00000365882#ENSG00000116670#ENST00000376692#Other#HORMA$#ENSP00000235310#ENSG00000116670#ENST00000235310#Other#HORMA$#ENSP00000365855#ENSG00000116670#ENST00000376667#Other#HORMA$#ENSP00000400982#ENSG00000116670#ENST00000456915#Other#HORMA$#ENSP00000365857#ENSG00000116670#ENST00000376669#Other#HORMA$#ENSP00000365860#ENSG00000116670#ENST00000376672#Other#HORMA$#ENSP00000411807#ENSG00000116670#ENST00000445656#Other#HORMA FALSE 2173 ENSG00000172175 MALT1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Protein that operates upstream of NFKB in a signaling cascade (PMID: 18223652) IPR001309;IPR003598;IPR003599;IPR007110;IPR011029;IPR011600 10892 MALT1 paracaspase [Source:HGNC Symbol;Acc:HGNC:6819];Mucosa-associated lymphoid tissue lymphoma tran None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Matt Weirauch Arttu Jolma No $#ENSG00000172175#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IMP - PMID:18223652 $#ENSP00000304161#ENSG00000172175#ENST00000345724#Other#I-set, Ig_2, Ig_3, Ig_4, Ig_5, Izumo-Ig, Peptidase$#ENSP00000319279#ENSG00000172175#ENST00000348428#Other#I-set, Ig_2, Ig_3, Ig_4, Ig_5, Izumo-Ig, Peptidase$#ENSP00000467222#ENSG00000172175#ENST00000591792#Other#I-set, Ig_2, Ig_3, Ig_5, V-set, ig FALSE 2174 ENSG00000161021 MAML1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None MAML1 does not contact the DNA in the structure (PDB: 2F8X), but contacts RBPJ, which in turn binds DNA IPR019082 9794 mastermind like transcriptional coactivator 1 [Source:HGNC Symbol;Acc:HGNC:13632] 2F8X not tested Yes None MAML1 does not contact the DNA in the structure, but contacts RBPJ that in turn binds DNA;Putative TFs that are justr in the TF-CAT No No TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_Co-activation_PMIDS:16530044 No 5a, one of the source datasets predicts is as a TF Matt Weirauch Arttu Jolma No None $##ENSG00000161021##Other# FALSE 2175 ENSG00000196782 MAML3 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR019082 55534 Mastermind like transcriptional coactivator 3 [Source:HGNC Symbol;Acc:HGNC:16272] None not tested not tested None None No No TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_TF PPI; Transactivation_PMIDS:12370315 Yes 4a, two or more datasets predict it as a TF Pratyush Das Yimeng Yin No None $#ENSP00000421180#ENSG00000196782#ENST00000509479#Other#MamL-1$#ENSP00000422783#ENSG00000196782#ENST00000502696#Other#$#ENSP00000381913#ENSG00000196782#ENST00000398940#Other# FALSE 2176 ENSG00000137764 MAP2K5 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Kinase that operates upstream in the signaling cascade that leads to NFKB IPR000270;IPR000719;IPR002290;IPR008271;IPR011009;IPR017441 5607 mitogen-activated protein kinase kinase 5 [Source:HGNC Symbol;Acc:HGNC:6845] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Matt Weirauch Arttu Jolma No $#ENSG00000137764#GO:0032088#negative regulation of NF-kappaB transcription factor activity#ISS - PMID:20551324 $#ENSP00000178640#ENSG00000137764#ENST00000178640#Other#Kinase-like, PB1, Pkinase, Pkinase_Tyr$#ENSP00000378859#ENSG00000137764#ENST00000395476#Other#Kinase-like, PB1, Pkinase, Pkinase_Tyr$#ENSP00000342101#ENSG00000137764#ENST00000340972#Other#Kinase-like, Pkinase, Pkinase_Tyr$#ENSP00000346493#ENSG00000137764#ENST00000354498#Other#Kinase-like, PB1, Pkinase, Pkinase_Tyr$#ENSP00000390196#ENSG00000137764#ENST00000439036#Other#$#ENSP00000483771#ENSG00000137764#ENST00000557869#Other# FALSE 2177 ENSG00000130758 MAP3K10 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000719;IPR001245;IPR001452;IPR002290;IPR008271;IPR011009;IPR016231;IPR017441 4294 mitogen-activated protein kinase kinase kinase 10 [Source:HGNC Symbol;Acc:HGNC:6849] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Laura Campitelli Matt Weirauch No $#ENSG00000130758#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#IMP - PMID:19801649 $#ENSP00000253055#ENSG00000130758#ENST00000253055#Other#Pkinase, Pkinase_Tyr, SH3_1, SH3_2, SH3_9 FALSE 2178 ENSG00000073803 MAP3K13 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000719;IPR001245;IPR002290;IPR008271;IPR011009;IPR017419;IPR027258 9175 mitogen-activated protein kinase kinase kinase 13 [Source:HGNC Symbol;Acc:HGNC:6852] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Matt Weirauch Yimeng Yin No $#ENSG00000073803#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IDA - PMID:12492477 $#ENSP00000265026#ENSG00000073803#ENST00000265026#Other#Pkinase, Pkinase_Tyr$#ENSP00000399910#ENSG00000073803#ENST00000424227#Other#Pkinase, Pkinase_Tyr$#ENSP00000392223#ENSG00000073803#ENST00000448876#Other#$#ENSP00000415712#ENSG00000073803#ENST00000420577#Other#Pkinase, Pkinase_Tyr$#ENSP00000390323#ENSG00000073803#ENST00000438798#Other#$#ENSP00000409325#ENSG00000073803#ENST00000443863#Other#Pkinase, Pkinase_Tyr$#ENSP00000411483#ENSG00000073803#ENST00000446828#Other#Pkinase, Pkinase_Tyr$#ENSP00000389495#ENSG00000073803#ENST00000447637#Other#$#ENSP00000412037#ENSG00000073803#ENST00000454237#Other# FALSE 2179 ENSG00000135341 MAP3K7 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Protein is a kinase IPR000719;IPR001245;IPR002290;IPR008271;IPR011009;IPR017421;IPR017441 6885 mitogen-activated protein kinase kinase kinase 7 [Source:HGNC Symbol;Acc:HGNC:6859] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Arttu Jolma Jussi Taipale No $#ENSG00000135341#GO:0051092#positive regulation of NF-kappaB transcription factor activity#TAS - Reactome:R-HSA-445989 $#ENSP00000358331#ENSG00000135341#ENST00000369325#Other#APH, Pkinase, Pkinase_Tyr$#ENSP00000358333#ENSG00000135341#ENST00000369327#Other#APH, Pkinase, Pkinase_Tyr$#ENSP00000358335#ENSG00000135341#ENST00000369329#Other#APH, Pkinase, Pkinase_Tyr$#ENSP00000358338#ENSG00000135341#ENST00000369332#Other#APH, Pkinase, Pkinase_Tyr FALSE 2180 ENSG00000100030 MAPK1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None MAP kinase; protein array paper evidence is not strong IPR000719;IPR002290;IPR003527;IPR008271;IPR008349;IPR011009;IPR017441 5594 mitogen-activated protein kinase 1 [Source:HGNC Symbol;Acc:HGNC:6871] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Tim Hughes Laura Campitelli No $#ENSG00000100030#GO:0051090#regulation of sequence-specific DNA binding transcription factor activity#TAS - Reactome:R-HSA-450341 $#ENSP00000215832#ENSG00000100030#ENST00000215832#Other#APH, Pkinase, Pkinase_Tyr$#ENSP00000381803#ENSG00000100030#ENST00000398822#Other#APH, Pkinase, Pkinase_Tyr$#ENSP00000440842#ENSG00000100030#ENST00000544786#Other#APH, Pkinase, Pkinase_Tyr FALSE 2181 ENSG00000109339 MAPK10 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Protein is a kinase IPR000719;IPR002290;IPR003527;IPR008271;IPR008351;IPR011009 5602 mitogen-activated protein kinase 10 [Source:HGNC Symbol;Acc:HGNC:6872] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Pratyush Das Arttu Jolma No $#ENSG00000109339#GO:0051090#regulation of sequence-specific DNA binding transcription factor activity#TAS - Reactome:R-HSA-450341 $#ENSP00000352157#ENSG00000109339#ENST00000359221#Other#APH, Kdo, Kinase-like, Pkinase, Pkinase_Tyr, RIO1$#ENSP00000355297#ENSG00000109339#ENST00000361569#Other#APH, Kdo, Kinase-like, Pkinase, Pkinase_Tyr, RIO1$#ENSP00000378586#ENSG00000109339#ENST00000395157#Other#APH, Kdo, Kinase-like, Pkinase, Pkinase_Tyr$#ENSP00000378589#ENSG00000109339#ENST00000395160#Other#APH, Kdo, Kinase-like, Pkinase, Pkinase_Tyr$#ENSP00000378598#ENSG00000109339#ENST00000395169#Other#APH, Kdo, Kinase-like, Pkinase, Pkinase_Tyr, RIO1$#ENSP00000414469#ENSG00000109339#ENST00000449047#Other#APH, Kdo, Kinase-like, Pkinase, Pkinase_Tyr$#ENSP00000378595#ENSG00000109339#ENST00000395166#Other#APH, Kdo, Kinase-like, Pkinase, Pkinase_Tyr, RIO1$#ENSP00000424154#ENSG00000109339#ENST00000515400#Other#APH, Kdo, Kinase-like, Pkinase, Pkinase_Tyr, RIO1$#ENSP00000420987#ENSG00000109339#ENST00000513186#Other# FALSE 2182 ENSG00000185386 MAPK11 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000719;IPR002290;IPR003527;IPR008352;IPR011009;IPR017441 5600 mitogen-activated protein kinase 11 [Source:HGNC Symbol;Acc:HGNC:6873] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Sam Lambert Jussi Taipale No $#ENSG00000185386#GO:0051090#regulation of sequence-specific DNA binding transcription factor activity#TAS - Reactome:R-HSA-450341 $#ENSP00000333685#ENSG00000185386#ENST00000330651#Other#APH, Cas_CT1975, Kdo, Pkinase, Pkinase_Tyr, RIO1 FALSE 2183 ENSG00000112062 MAPK14 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Well characterized MAPK. Included because it as a regulator of several TFs and GO captures this. IPR000719;IPR002290;IPR003527;IPR008352;IPR011009;IPR017441 1432 mitogen-activated protein kinase 14 [Source:HGNC Symbol;Acc:HGNC:6876] None not tested not tested None None No No Probably Not a TF - No evidence that it is a TF__TF PPI_PMIDS:9069290;9858528 Yes 5a, one of the source datasets predicts is as a TF Tim Hughes Laura Campitelli No $#ENSG00000112062#GO:0051090#regulation of sequence-specific DNA binding transcription factor activity#TAS - Reactome:R-HSA-450341 $#ENSP00000229794#ENSG00000112062#ENST00000229794#Other#APH, Kdo, Pkinase, Pkinase_Tyr$#ENSP00000229795#ENSG00000112062#ENST00000229795#Other#APH, Kdo, Pkinase, Pkinase_Tyr$#ENSP00000308669#ENSG00000112062#ENST00000310795#Other#APH, Kdo, Pkinase, Pkinase_Tyr$#ENSP00000419837#ENSG00000112062#ENST00000468133#Other#Pkinase, Pkinase_Tyr FALSE 2184 ENSG00000102882 MAPK3 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000719;IPR002290;IPR003527;IPR008271;IPR008349;IPR011009;IPR017441 5595 mitogen-activated protein kinase 3 [Source:HGNC Symbol;Acc:HGNC:6877] None not tested not tested None None No No Probably Not a TF - No evidence that it is a TF__TF PPI_PMIDS:7889942;8657129 Yes 5a, one of the source datasets predicts is as a TF Sam Lambert Pratyush Das No $#ENSG00000102882#GO:0051090#regulation of sequence-specific DNA binding transcription factor activity#TAS - Reactome:R-HSA-450341 $#ENSP00000263025#ENSG00000102882#ENST00000263025#Other#APH, Pkinase, Pkinase_Tyr$#ENSP00000378625#ENSG00000102882#ENST00000395199#Other#APH, Pkinase, Pkinase_Tyr$#ENSP00000378628#ENSG00000102882#ENST00000395202#Other#APH, Pkinase, Pkinase_Tyr$#ENSP00000432742#ENSG00000102882#ENST00000484663#Other#APH, Pkinase, Pkinase_Tyr$#ENSP00000378626#ENSG00000102882#ENST00000395200#Other#Pkinase, Pkinase_Tyr FALSE 2185 ENSG00000107643 MAPK8 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000719;IPR002290;IPR003527;IPR008271;IPR008351;IPR011009 5599 mitogen-activated protein kinase 8 [Source:HGNC Symbol;Acc:HGNC:6881] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Yimeng Yin Matt Weirauch No $#ENSG00000107643#GO:0051090#regulation of sequence-specific DNA binding transcription factor activity#TAS - Reactome:R-HSA-450341 $#ENSP00000353483#ENSG00000107643#ENST00000360332#Other#APH, Kdo, Kinase-like, Pkinase, Pkinase_Tyr, RIO1$#ENSP00000363291#ENSG00000107643#ENST00000374176#Other#APH, Kdo, Kinase-like, Pkinase, Pkinase_Tyr, RIO1$#ENSP00000363294#ENSG00000107643#ENST00000374179#Other#APH, Kdo, Kinase-like, Pkinase, Pkinase_Tyr, RIO1$#ENSP00000363297#ENSG00000107643#ENST00000374182#Other#APH, Kdo, Kinase-like, Pkinase, Pkinase_Tyr, RIO1$#ENSP00000378974#ENSG00000107643#ENST00000395611#Other#APH, Kdo, Kinase-like, Pkinase, Pkinase_Tyr, RIO1$#ENSP00000363289#ENSG00000107643#ENST00000374174#Other#APH, Kdo, Kinase-like, Pkinase, Pkinase_Tyr, RIO1$#ENSP00000387936#ENSG00000107643#ENST00000432379#Other#Pkinase, Pkinase_Tyr FALSE 2186 ENSG00000050748 MAPK9 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000719;IPR002290;IPR003527;IPR008271;IPR008351;IPR011009 5601 mitogen-activated protein kinase 9 [Source:HGNC Symbol;Acc:HGNC:6886] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Pratyush Das Sam Lambert No $#ENSG00000050748#GO:0051090#regulation of sequence-specific DNA binding transcription factor activity#TAS - Reactome:R-HSA-450341 $#ENSP00000380262#ENSG00000050748#ENST00000397072#Other#$#ENSP00000443149#ENSG00000050748#ENST00000539014#Other#APH, Kdo, Kinase-like, Pkinase, Pkinase_Tyr, RIO1$#ENSP00000389338#ENSG00000050748#ENST00000455781#Other#APH, Kdo, Kinase-like, Pkinase, Pkinase_Tyr, RIO1 FALSE 2187 ENSG00000015479 MATR3 Unknown No ssDNA/RNA binding Not a DNA binding protein No motif None An RBP that recognizes MAUCUUR-site based on Ray et al 2013 (PMID: 23846655) IPR000504;IPR000690;IPR003604; 9782 matrin 3 [Source:HGNC Symbol;Acc:HGNC:6912] None not tested not tested None None c No No No 5a, one of the source datasets predicts is as a TF Pratyush Das Arttu Jolma No None $#ENSP00000378284#ENSG00000015479#ENST00000394805#Other#$#ENSP00000423587#ENSG00000015479#ENST00000503811#Other#$#ENSP00000425167#ENSG00000015479#ENST00000511378#Other#$#ENSP00000424646#ENSG00000015479#ENST00000513678#Other#$#ENSP00000422590#ENSG00000015479#ENST00000503340#Other#$#ENSP00000422700#ENSG00000015479#ENST00000504311#Other#$#ENSP00000425150#ENSG00000015479#ENST00000512876#Other# FALSE 2188 ENSG00000088888 MAVS Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Operates upstream in the signaling cascade that activates innate immunity response for viruses through NFLB and IRF3 TFs IPR026148;IPR031964 57506 mitochondrial antiviral signaling protein [Source:HGNC Symbol;Acc:HGNC:29233] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Jussi Taipale Arttu Jolma No $#ENSG00000088888#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:16127453 $#ENSP00000413749#ENSG00000088888#ENST00000416600#Other#$#ENSP00000401980#ENSG00000088888#ENST00000428216#Other#CARD_2 FALSE 2189 ENSG00000164430 MB21D1 Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None Binds DNA with backbone contacts and one minor groove inserting Arginine in the crystal structure (PDB: 4LEY) None None Mab-21 domain containing 1 4LEY not tested not tested None Binds DNA with backbone contacts and one minor groove inserting Arginine in the crystal structure (PDB: 4LEY) No No No No New proteins added based on PDB entry Arttu Jolma Sam Lambert No None None FALSE 2190 ENSG00000012174 MBTPS2 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None GO annotation has no evidence of DNA-binding activity, only modulation of TF activity (PMID: 11163209) IPR001193;IPR001478;IPR008915 51360 membrane bound transcription factor peptidase, site 2 [Source:HGNC Symbol;Acc:HGNC:15455] None not tested Yes None None No No No Yes 5a, one of the source datasets predicts is as a TF Matt Weirauch Sam Lambert No $#ENSG00000012174#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IGI - PMID:11163209 $#ENSP00000368796#ENSG00000012174#ENST00000365779#Other#DUF4667, PDZ_2, Peptidase_M50$#ENSP00000368798#ENSG00000012174#ENST00000379484#Other#DUF4667, PDZ_2, Peptidase_M50 FALSE 2191 ENSG00000112559 MDFI Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None MDF1 is a co-repressor that inhibits DNA-binding (PMID: 8797820) IPR026134 4188 MyoD family inhibitor [Source:HGNC Symbol;Acc:HGNC:6967] None not tested not tested None None No No TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_Co-activation_PMIDS:8797820 No 5a, one of the source datasets predicts is as a TF Sam Lambert Matt Weirauch No None $##ENSG00000112559##Other# FALSE 2192 ENSG00000135679 MDM2 Unknown No ssDNA/RNA binding Not a DNA binding protein No motif None None IPR001841;IPR001876;IPR003121;IPR016495;IPR028340 4193 MDM2 proto-oncogene [Source:HGNC Symbol;Acc:HGNC:6973] None not tested Yes None None No No TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_Co-activation_PMIDS:9271120 No 5a, one of the source datasets predicts is as a TF Matt Weirauch Pratyush Das No None $##ENSG00000135679##Other# FALSE 2193 ENSG00000198625 MDM4 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Protein binds to, and inhibits, p53 (PMID: 9226370) IPR001841;IPR001876;IPR003121;IPR015458;IPR016495 4194 MDM4, p53 regulator [Source:HGNC Symbol;Acc:HGNC:6974] None not tested not tested None None No No TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:9226370 No 5a, one of the source datasets predicts is as a TF Yimeng Yin Arttu Jolma No None $##ENSG00000198625##Other# FALSE 2194 ENSG00000125686 MED1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None This is a component of Mediator. IPR019680 5469 mediator complex subunit 1 [Source:HGNC Symbol;Acc:HGNC:9234];Mediator of RNA polymerase II transcri None not tested not tested None None No No TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_Co-activation; TF PPI_PMIDS:10037764 Yes 4a, two or more datasets predict it as a TF Tim Hughes Jussi Taipale No $#ENSG00000125686#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#ISS - GO_REF:0000024 $#ENSP00000300651#ENSG00000125686#ENST00000300651#Other#Med1$#ENSP00000377828#ENSG00000125686#ENST00000394287#Other#Med1 FALSE 2195 ENSG00000184634 MED12 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR019035;IPR021989;IPR021990 9968 mediator complex subunit 12 [Source:HGNC Symbol;Acc:HGNC:11957] None not tested not tested None None No No Indeterminate - There is no evidence for or against this genes role as a TF__TF PPI_PMIDS:12612078 No 5a, one of the source datasets predicts is as a TF Yimeng Yin Sam Lambert No None $##ENSG00000184634##Other# FALSE 2196 ENSG00000108510 MED13 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None None 9969 Mediator of RNA polymerase II transcription subunit 13 None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Laura Campitelli Matt Weirauch No $#ENSG00000108510#GO:1904168#negative regulation of thyroid hormone receptor activity#IEA - GO_REF:0000019 $##ENSG00000108510##Other# FALSE 2197 ENSG00000123066 MED13L Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR009401;IPR021643 23389 mediator complex subunit 13 like [Source:HGNC Symbol;Acc:HGNC:22962] None not tested not tested None None No No Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0 No 5a, one of the source datasets predicts is as a TF Jussi Taipale Yimeng Yin No None $##ENSG00000123066##Other# FALSE 2198 ENSG00000180182 MED14 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR013947 9282 mediator complex subunit 14 [Source:HGNC Symbol;Acc:HGNC:2370] None not tested not tested None None No No TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:9989412 No 5a, one of the source datasets predicts is as a TF Sam Lambert Laura Campitelli No None $##ENSG00000180182##Other# FALSE 2199 ENSG00000099917 MED15 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR019087 51586 mediator complex subunit 15 [Source:HGNC Symbol;Acc:HGNC:14248] None not tested not tested None None No No TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_Transactivation_PMIDS:12167862 No 5a, one of the source datasets predicts is as a TF Yimeng Yin Matt Weirauch No None $##ENSG00000099917##Other# FALSE 2200 ENSG00000175221 MED16 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None This is a component of Mediator. IPR001680;IPR017986;IPR021665 10025 mediator complex subunit 16 [Source:HGNC Symbol;Acc:HGNC:17556] None not tested not tested None None No No Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0 No 5a, one of the source datasets predicts is as a TF Sam Lambert Laura Campitelli No None $##ENSG00000175221##Other# FALSE 2201 ENSG00000042429 MED17 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR019313 9440 mediator complex subunit 17 [Source:HGNC Symbol;Acc:HGNC:2375] 4V1O not tested not tested None None No No TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_Co-activation; TF PPI_PMIDS:9989412 No 5a, one of the source datasets predicts is as a TF Laura Campitelli Yimeng Yin No None $##ENSG00000042429##Other# FALSE 2202 ENSG00000152944 MED21 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Does not contact DNA in the structure of the yeast mediator complex (PDB: 5SVA) IPR021384 9412 mediator complex subunit 21 [Source:HGNC Symbol;Acc:HGNC:11473] None not tested not tested None None No No TF Gene_Basal Transcription Factor_Co-activation_PMIDS:8598913;9159119 No 5a, one of the source datasets predicts is as a TF Sam Lambert Arttu Jolma No None $##ENSG00000152944##Other# FALSE 2203 ENSG00000112282 MED23 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR021629 9439 mediator complex subunit 23 [Source:HGNC Symbol;Acc:HGNC:2372] None not tested not tested None None No No TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:9989412 No 5a, one of the source datasets predicts is as a TF Jussi Taipale Pratyush Das No None $##ENSG00000112282##Other# FALSE 2204 ENSG00000008838 MED24 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR021429 102466757 mediator complex subunit 24 [Source:HGNC Symbol;Acc:HGNC:22963] None not tested not tested None None No No TF Gene_Transcription Factor Binding: tf co-factor binding_Co-activation; TF PPI_PMIDS:9637681;10406464;12093747 No 5a, one of the source datasets predicts is as a TF Yimeng Yin Matt Weirauch No None $##ENSG00000008838##Other# FALSE 2205 ENSG00000133997 MED6 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Does not bind anywhere near DNA on crystal structure (PDB: 4V1O) IPR007018;IPR016820 10001 mediator complex subunit 6 [Source:HGNC Symbol;Acc:HGNC:19970] 4V1O not tested not tested None Structure is for yeast mediator complex No No TF Gene Candidate_Transcription Factor Binding: tf co-factor binding__PMIDS:0;9234719;9671455 No 5a, one of the source datasets predicts is as a TF Arttu Jolma Sam Lambert No None $##ENSG00000133997##Other# FALSE 2206 ENSG00000133895 MEN1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Interacts with NFKB1 (PMID: 11526476), JUN, JUND, and ELK1 and represses their activities with a mechanism that is at least for JUN and JUND dependent on their phosphorylation IPR007747 4221 menin 1 [Source:HGNC Symbol;Acc:HGNC:7010] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Arttu Jolma Pratyush Das No $#ENSG00000133895#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:11526476, PMID:12226747 $#ENSP00000308975#ENSG00000133895#ENST00000312049#Other#Menin$#ENSP00000366538#ENSG00000133895#ENST00000377321#Other#Menin$#ENSP00000388016#ENSG00000133895#ENST00000424912#Other#Menin$#ENSP00000402752#ENSG00000133895#ENST00000429702#Other#Menin$#ENSP00000366530#ENSG00000133895#ENST00000377313#Other#Menin$#ENSP00000411218#ENSG00000133895#ENST00000413626#Other#Menin FALSE 2207 ENSG00000105976 MET Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Its a cell surface receptor and kinase - included only because Vasquerizas 2009 included it with an x. IPR000719;IPR001245;IPR001627;IPR002165;IPR002909;IPR008266;IPR011009;IPR014756;IPR016201;IPR016244;IPR017441; 4233 MET proto-oncogene, receptor tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:7029] None Full not tested None None x No No No 5a, one of the source datasets predicts is as a TF Matt Weirauch Tim Hughes No None $#ENSP00000317272#ENSG00000105976#ENST00000318493#Other#Kinase-like, PSI, Pkinase, Pkinase_Tyr, Sema, TIG$#ENSP00000380860#ENSG00000105976#ENST00000397752#Other#Kinase-like, PSI, Pkinase, Pkinase_Tyr, Sema, TIG$#ENSP00000410980#ENSG00000105976#ENST00000436117#Other#PSI, Sema, TIG$#ENSP00000413857#ENSG00000105976#ENST00000456159#Other#Sema$#ENSP00000398776#ENSG00000105976#ENST00000422097#Other#TIG FALSE 2208 ENSG00000170430 MGMT Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None O6-Alklyguanine-DNA alkyltransferase (AGT) is an important DNA repair protein that protects cells from mutagenesis and toxicity arising from alkylating agents (PMID: 15964013); structure (PDB: 1YFH) is with cytosine alkylated DNA IPR001497;IPR008332;IPR014048; 4255 O-6-methylguanine-DNA methyltransferase [Source:HGNC Symbol;Acc:HGNC:7059] 1YFH not tested not tested None Pmid: 15964013 O6-Alklyguanine-DNA alkyltransferase (AGT) is an important DNA repair protein that protects cells from mutagenesis and toxicity arising from alkylating agents x No No No 1a1, Direct HQ evidence Arttu Jolma Pratyush Das No None $#ENSP00000302111#ENSG00000170430#ENST00000306010#Other#DNA_binding_1, Methyltransf_1N FALSE 2209 ENSG00000080561 MID2 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None GO citation (PMID: 23077300) has no evidence of DNA-binding activity IPR000315;IPR001841;IPR001870;IPR003649;IPR003877;IPR003879;IPR003961;IPR013320;IPR017903;IPR017907 11043 midline 2 [Source:HGNC Symbol;Acc:HGNC:7096];Probable E3 ubiquitin-protein ligase MID2 None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Sam Lambert Laura Campitelli No $#ENSG00000080561#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IMP - PMID:23077300$#ENSG00000080561#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IMP - PMID:23077300 $#ENSP00000262843#ENSG00000080561#ENST00000262843#Other#PRY, SPRY, fn3, zf-B_box, zf-C3HC4, zf-C3HC4_2, zf$#ENSP00000413976#ENSG00000080561#ENST00000443968#Other#PRY, SPRY, fn3, zf-B_box, zf-C3HC4, zf-C3HC4_2, zf$#ENSP00000410730#ENSG00000080561#ENST00000451923#Other#CEBP_ZZ, zf-B_box, zf-C3HC4, zf-C3HC4_2, zf-C3HC4_ FALSE 2210 ENSG00000141503 MINK1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000719;IPR001180;IPR002290;IPR008271;IPR011009;IPR017441 50488 misshapen like kinase 1 [Source:HGNC Symbol;Acc:HGNC:17565] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Laura Campitelli Yimeng Yin No None $#ENSP00000269296#ENSG00000141503#ENST00000347992#Other#CNH, Pkinase, Pkinase_Tyr$#ENSP00000347427#ENSG00000141503#ENST00000355280#Other#CNH, Pkinase, Pkinase_Tyr$#ENSP00000406487#ENSG00000141503#ENST00000453408#Other#CNH, Pkinase, Pkinase_Tyr$#ENSP00000459102#ENSG00000141503#ENST00000576037#Other#CNH FALSE 2211 ENSG00000196588 MKL1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Transcriptional co-factor None 57591 MKL/myocardin-like protein 1 None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Jussi Taipale Sam Lambert No $#ENSG00000196588#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019 $##ENSG00000196588##Other# FALSE 2212 ENSG00000186260 MKL2 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR003034;IPR004018 57496 MKL1/myocardin like 2 [Source:HGNC Symbol;Acc:HGNC:29819] None not tested not tested None None No No TF Gene_Transcription Factor Binding: tf co-factor binding_Co-activation_PMIDS:12944485;17363709 No 5a, one of the source datasets predicts is as a TF Sam Lambert Jussi Taipale No None $##ENSG00000186260##Other# FALSE 2213 ENSG00000179455 MKRN3 Unknown No ssDNA/RNA binding Not a DNA binding protein No motif None Likely E3 ubiquitin ligase. Contains a RING (C3HC4) zinc finger motif and several C3H zinc finger motifs IPR000571;IPR001841;IPR017907;IPR018957 7681 makorin ring finger protein 3 [Source:HGNC Symbol;Acc:HGNC:7114] None Full not tested None None x No No No 5a, one of the source datasets predicts is as a TF Jussi Taipale Laura Campitelli No None $#ENSP00000456779#ENSG00000179455#ENST00000568252#Other#$#ENSP00000455368#ENSG00000179455#ENST00000564592#Other#$#ENSP00000313881#ENSG00000179455#ENST00000314520#Other#MKRN1_C, zf-ANAPC11, zf-C3HC4, zf-C3HC4_4, zf-RING FALSE 2214 ENSG00000130382 MLLT1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None X-ray structure indicates histone binding (PDB: 4TMP) IPR005033; 4298 myeloid/lymphoid or mixed-lineage leukemia; translocated to, 1 [Source:HGNC Symbol;Acc:HGNC:7134] None DBD not tested None None b No TF Gene_Transcription Factor Binding: tf co-factor binding_Co-activation; TF PPI_PMIDS:15096481 No 4a, two or more datasets predict it as a TF Sam Lambert Laura Campitelli No None $#ENSP00000252674#ENSG00000130382#ENST00000252674#Other#YEATS FALSE 2215 ENSG00000078403 MLLT10 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif Has a putative AT-hook No evidence showing MLLT10 can bind to DNA in a sequence-specific manner (PMID: 7888665) IPR001965;IPR011011;IPR019786;IPR019787 8028 myeloid/lymphoid or mixed-lineage leukemia; translocated to, 10 [Source:HGNC Symbol;Acc:HGNC:16063] None not tested not tested None None No No Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0 Yes 5a, one of the source datasets predicts is as a TF Yimeng Yin Matt Weirauch No $#ENSG00000078403#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:7888665 $#ENSP00000307411#ENSG00000078403#ENST00000307729#Other#PHD, PHD_2, zf-HC5HC2H, zf-HC5HC2H_2$#ENSP00000366258#ENSG00000078403#ENST00000377059#Other#PHD, PHD_2, zf-HC5HC2H, zf-HC5HC2H_2$#ENSP00000366272#ENSG00000078403#ENST00000377072#Other#PHD, PHD_2, zf-HC5HC2H, zf-HC5HC2H_2$#ENSP00000366295#ENSG00000078403#ENST00000377091#Other#PHD, PHD_2$#ENSP00000397800#ENSG00000078403#ENST00000430455#Other#PHD, PHD_2$#ENSP00000484335#ENSG00000078403#ENST00000621220#Other#PHD, PHD_2$#ENSP00000366304#ENSG00000078403#ENST00000377100#Other#PHD, PHD_2$#ENSP00000399883#ENSG00000078403#ENST00000420525#Other# FALSE 2216 ENSG00000213190 MLLT11 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None None 10962 myeloid/lymphoid or mixed-lineage leukemia; translocated to, 11 [Source:HGNC Symbol;Acc:HGNC:16997] None not tested not tested None None No No TF Gene Candidate__Other_PMIDS:15530661 No 5a, one of the source datasets predicts is as a TF Laura Campitelli Arttu Jolma No None $##ENSG00000213190##Other# FALSE 2217 ENSG00000171843 MLLT3 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Transcription elongation factor [PMID: 20159561; PMID: 20471948] IPR005033; 4300 myeloid/lymphoid or mixed-lineage leukemia; translocated to, 3 [Source:HGNC Symbol;Acc:HGNC:7136] None DBD not tested None None b No TF Gene_Transcription Factor Binding: tf co-factor binding; Transcription Regulatory Activity: heterochromatin interaction/binding_Co-activation_PMIDS:12776190;16636056 No 4a, two or more datasets predict it as a TF Sam Lambert Laura Campitelli No None $#ENSP00000369695#ENSG00000171843#ENST00000380338#Other#YEATS$#ENSP00000485996#ENSG00000171843#ENST00000630269#Other#YEATS$#ENSP00000369678#ENSG00000171843#ENST00000380321#Other#BET$#ENSP00000486193#ENSG00000171843#ENST00000629733#Other# FALSE 2218 ENSG00000275023 MLLT6 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif Has a putative AT-hook Likely to be a transcriptional cofactor based on presence of PHD domains and (PMID: 15588942) IPR001965;IPR011011;IPR019786;IPR019787 4302 myeloid/lymphoid or mixed-lineage leukemia; translocated to, 6 [Source:HGNC Symbol;Acc:HGNC:7138] None not tested not tested None None No No TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:15588942 No 5a, one of the source datasets predicts is as a TF Yimeng Yin Arttu Jolma No None $##ENSG00000275023##Other# FALSE 2219 ENSG00000169184 MN1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Evidence for DNA binding not strong in (PMID: 12569362) None 4330 meningioma (disrupted in balanced translocation) 1 [Source:HGNC Symbol;Acc:HGNC:7180] None not tested not tested None None No No TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_Co-activation_PMIDS:12569362 No 5a, one of the source datasets predicts is as a TF Jussi Taipale Pratyush Das No None $##ENSG00000169184##Other# FALSE 2220 ENSG00000020426 MNAT1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR001841;IPR003903;IPR004575;IPR015877;IPR017907 4331 MNAT1, CDK activating kinase assembly factor [Source:HGNC Symbol;Acc:HGNC:7181] None not tested not tested None None No No TF Gene_Transcription Factor Binding: tf co-factor binding; Basal Transcription Factor_Co-activation; TF PPI_PMIDS:10801852 No 5a, one of the source datasets predicts is as a TF Laura Campitelli Yimeng Yin No None $##ENSG00000020426##Other# FALSE 2221 ENSG00000103152 MPG Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None DNA error repair enzyme that excises alkylation-damaged purine bases. Binds dsDNA in the crystal structure (PDB: 1BNK) None None N-methylpurine DNA glycosylase 1BNK not tested not tested None DNA error repair enzyme that excises alkylation-damaged purine bases. Binds dsDNA in the crystal structure (PDB: 1BNK) No No No No New proteins added based on PDB entry Arttu Jolma Sam Lambert No None None FALSE 2222 ENSG00000086504 MRPL28 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Included only because it has an X in Vaquerizas 2009 None 10573 mitochondrial ribosomal protein L28 [Source:HGNC Symbol;Acc:HGNC:14484] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Jussi Taipale Tim Hughes No None $#ENSP00000199706#ENSG00000086504#ENST00000199706#Other#Ribosomal_L28$#ENSP00000414038#ENSG00000086504#ENST00000429738#Other#$#ENSP00000374326#ENSG00000086504#ENST00000389675#Other#Ribosomal_L28$#ENSP00000390399#ENSG00000086504#ENST00000447696#Other#Ribosomal_L28$#ENSP00000395305#ENSG00000086504#ENST00000450882#Other#Ribosomal_L28 FALSE 2223 ENSG00000148187 MRRF Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR023584; 92399 mitochondrial ribosome recycling factor [Source:HGNC Symbol;Acc:HGNC:7234] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Yimeng Yin Arttu Jolma No None $#ENSP00000377850#ENSG00000148187#ENST00000394315#Other#RRF$#ENSP00000297908#ENSG00000148187#ENST00000297908#Other#14-3-3, RRF$#ENSP00000343867#ENSG00000148187#ENST00000344641#Other#RRF$#ENSP00000395072#ENSG00000148187#ENST00000441707#Other#RRF$#ENSP00000362828#ENSG00000148187#ENST00000373723#Other#RRF$#ENSP00000362834#ENSG00000148187#ENST00000373729#Other#14-3-3, RRF FALSE 2224 ENSG00000095002 MSH2 Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None Binds DNA that has a base mismatch as a heterodimer with MSH6. Binds DNA in the crystal structure (PDB: 2O8B) None None mutS homolog 2 2O8B not tested not tested None Binds DNA that has a base mismatch as a heterodimer with MSH6. Binds DNA in the crystal structure (PDB: 2O8B) No No No No New proteins added based on PDB entry Arttu Jolma Sam Lambert No None None FALSE 2225 ENSG00000113318 MSH3 Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None Involved in mismatch repair - binds dsDNA with indels (PDB: 3THZ) and changes DNA shape None None mutS homolog 3 3THZ not tested not tested None Involved in mismatch repair - binds dsDNA with indels (PDB: 3THZ) and changes DNA shape No No No No New proteins added based on PDB entry Arttu Jolma Sam Lambert No None None FALSE 2226 ENSG00000116062 MSH6 Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None Binds DNA that has base mismatches as a heterodimer with MSH2. Binds DNA in the crystal structure (PDB: 2O8B) None None mutS homolog 6 2O8B not tested not tested None Binds DNA that has base mismatches as a heterodimer with MSH2. Binds DNA in the crystal structure (PDB: 2O8B) No No No No New proteins added based on PDB entry Arttu Jolma Sam Lambert No None None FALSE 2227 ENSG00000005302 MSL3 Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None Binds DNA in the crystal structure (PDB: 3OA6). Contacts only the backbone and doesnt cause large changes in the DNA shape None None male-specific lethal 3 homolog (Drosophila) 3OA6 not tested not tested None Binds DNA in the crystal structure (PDB: 3OA6). Contacts only the backbone and doesn't cause large changes in the DNA shape No No No No New proteins added based on PDB entry Arttu Jolma Sam Lambert No None None FALSE 2228 ENSG00000148450 MSRB2 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None The paper cited by GO (PMID:10375640) called MSRB2 a TF based on amino acid sequence analysis, but did not provide any direct evidence IPR002579;IPR011057 22921 methionine sulfoxide reductase B2 [Source:HGNC Symbol;Acc:HGNC:17061] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Yimeng Yin Laura Campitelli No $#ENSG00000148450#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:10375640 $#ENSP00000365693#ENSG00000148450#ENST00000376510#Other#SelR FALSE 2229 ENSG00000164078 MST1R Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000719;IPR001245;IPR001627;IPR002909;IPR008266;IPR011009;IPR014756;IPR016201;IPR016244;IPR017441;IPR020635; 4486 macrophage stimulating 1 receptor [Source:HGNC Symbol;Acc:HGNC:7381] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Sam Lambert Laura Campitelli No None $#ENSP00000296474#ENSG00000164078#ENST00000296474#Other#Kinase-like, PSI, Pkinase, Pkinase_Tyr, Sema, TIG$#ENSP00000481084#ENSG00000164078#ENST00000612032#Other#Kinase-like, Pkinase, Pkinase_Tyr$#ENSP00000482827#ENSG00000164078#ENST00000613534#Other#Pkinase, Pkinase_Tyr, Sema$#ENSP00000482642#ENSG00000164078#ENST00000621387#Other#Kinase-like, PSI, Pkinase, Pkinase_Tyr, Sema, TIG$#ENSP00000414792#ENSG00000164078#ENST00000440292#Other#Pkinase, Pkinase_Tyr FALSE 2230 ENSG00000147649 MTDH Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR031402 92140 metadherin [Source:HGNC Symbol;Acc:HGNC:29608] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Matt Weirauch Laura Campitelli No $#ENSG00000147649#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IDA - PMID:16452207, PMID:18316612 $#ENSP00000338235#ENSG00000147649#ENST00000336273#Other#LYRIC$#ENSP00000428703#ENSG00000147649#ENST00000522313#Other#LYRIC$#ENSP00000428168#ENSG00000147649#ENST00000519934#Other#LYRIC$#ENSP00000429642#ENSG00000147649#ENST00000521933#Other#LYRIC FALSE 2231 ENSG00000143033 MTF2 Unknown Yes Known motif Monomer or homomultimer High-throughput in vitro None Recent study (PMID: 28869966) demonstrates direct, specific DNA binding to CG-rich sequences through PBMs, and crystal structure in complex with DNA IPR001965;IPR002999;IPR011011;IPR019786;IPR019787;IPR025894 22823 metal response element binding transcription factor 2 [Source:HGNC Symbol;Acc:HGNC:29535] None not tested not tested None None No No TF Gene Candidate__DNA Binding_PMIDS:7772254 No 5a, one of the source datasets predicts is as a TF Laura Campitelli Matt Weirauch No None $##ENSG00000143033##Other# FALSE 2232 ENSG00000105887 MTPN Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None No DBD; no evidence for DNA binding - only included because GO says its a positive regulator of NFkappaB. IPR002110;IPR020683 136319 myotrophin [Source:HGNC Symbol;Acc:HGNC:15667] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Pratyush Das Tim Hughes No $#ENSG00000105887#GO:0051092#positive regulation of NF-kappaB transcription factor activity#ISS - GO_REF:0000024 $#ENSP00000376800#ENSG00000105887#ENST00000393085#Other#Ank, Ank_2, Ank_3, Ank_4, Ank_5$#ENSP00000388321#ENSG00000105887#ENST00000435723#Other#Ank_5 FALSE 2233 ENSG00000172732 MUS81 Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None MUS81 is a structure-specific endonuclease subunit. It binds DNA in the crystal structure (PDB: 4P0P) in a heterodimeric complex with EME1. None None MUS81 structure-specific endonuclease subunit 4P0P not tested not tested None MUS81 is a structure-specific endonuclease subunit. It binds DNA in the crystal structure (PDB: 4P0P) in a heterodimeric complex with EME1. No No No No New proteins added based on PDB entry Arttu Jolma Sam Lambert No None None FALSE 2234 ENSG00000132382 MYBBP1A Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif Has a putative AT-hook Protein that activates TP53 (PMID: 24375404) and binds to MYB (PMID: 24375404); however, there is no evidence of direct binding to DNA IPR007015;IPR016024 10514 MYB binding protein 1a [Source:HGNC Symbol;Acc:HGNC:7546] None not tested not tested None None No No TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_Co-activation_PMIDS:8302594 No 5a, one of the source datasets predicts is as a TF Arttu Jolma Yimeng Yin No None $##ENSG00000132382##Other# FALSE 2235 ENSG00000214114 MYCBP Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None None 26292 MYC binding protein [Source:HGNC Symbol;Acc:HGNC:7554] None not tested not tested None None No No TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_TF PPI; Transactivation_PMIDS:9797456;9797456 No 5a, one of the source datasets predicts is as a TF Yimeng Yin Jussi Taipale No None $##ENSG00000214114##Other# FALSE 2236 ENSG00000172936 MYD88 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Operates upstream in the signaling cascade (PMID: 22155231) IPR000157;IPR000488;IPR011029;IPR017281 4615 Myeloid differentiation primary response 88 [Source:HGNC Symbol;Acc:HGNC:7562] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Arttu Jolma Pratyush Das No $#ENSG00000172936#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IMP - PMID:22155231 $#ENSP00000379625#ENSG00000172936#ENST00000396334#Other#Death, TIR, TIR_2$#ENSP00000401399#ENSG00000172936#ENST00000417037#Other#Death, TIR, TIR_2$#ENSP00000391753#ENSG00000172936#ENST00000421516#Other#Death, TIR, TIR_2$#ENSP00000389979#ENSG00000172936#ENST00000424893#Other#Death, TIR, TIR_2$#ENSP00000390565#ENSG00000172936#ENST00000443433#Other#Death$#ENSP00000417848#ENSG00000172936#ENST00000495303#Other#Death FALSE 2237 ENSG00000104177 MYEF2 Unknown No ssDNA/RNA binding Not a DNA binding protein No motif None Binds single-stranded DNA and can regulate transcription in transfection reporter assays IPR000504 50804 myelin expression factor 2 [Source:HGNC Symbol;Acc:HGNC:17940] None not tested not tested None None No No TF Gene_Single stranded RNA/DNA binding_DNA Binding; Other_PMIDS:7534248;7539003 Yes 4a, two or more datasets predict it as a TF Jussi Taipale Tim Hughes No None $#ENSP00000267836#ENSG00000104177#ENST00000267836#Other#$#ENSP00000316950#ENSG00000104177#ENST00000324324#Other#$#ENSP00000478898#ENSG00000104177#ENST00000616409#Other#$#ENSP00000480281#ENSG00000104177#ENST00000620867#Other# FALSE 2238 ENSG00000141052 MYOCD Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Transcriptional cofactor (PMID: 12640126) IPR003034;IPR004018 93649 myocardin [Source:HGNC Symbol;Acc:HGNC:16067] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Laura Campitelli Matt Weirauch No $#ENSG00000141052#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:22157009$#ENSG00000141052#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IDA - PMID:19578358$#ENSG00000141052#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:19098903 $#ENSP00000341835#ENSG00000141052#ENST00000343344#Other#RPEL, SAP$#ENSP00000401678#ENSG00000141052#ENST00000425538#Other#RPEL, SAP$#ENSP00000400148#ENSG00000141052#ENST00000443061#Other#SAP FALSE 2239 ENSG00000166886 NAB2 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Well characterized transcriptional co-repressor of e.g. EGR1 (PMID: 12427750) IPR006988;IPR006989 4665 NGFI-A binding protein 2 [Source:HGNC Symbol;Acc:HGNC:7627] None not tested not tested None None No No TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_Co-activation_PMIDS:10734128;12427750 No 5a, one of the source datasets predicts is as a TF Laura Campitelli Sam Lambert No None $##ENSG00000166886##Other# FALSE 2240 ENSG00000139579 NABP2 Unknown No ssDNA/RNA binding Not a DNA binding protein No motif None Binds single stranded DNA in the structure (PDB: 4OWW) None None nucleic acid binding protein 2 4OWW not tested not tested None Binds single stranded DNA in the structure (PDB: 4OWW) No No No No New proteins added based on PDB entry Arttu Jolma Sam Lambert No None None FALSE 2241 ENSG00000148411 NACC2 Unknown Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Binds DNA as a homodimer, recognizing a TGTCRSWWYYGWC consensus based on SELEX experiments (PMID: 22926524) IPR000210;IPR011333;IPR013069;IPR018379 138151 NACC family member 2 [Source:HGNC Symbol;Acc:HGNC:23846];Nucleus accumbens-associated protein 2 None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Pratyush Das Arttu Jolma No $#ENSG00000148411#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:22926524 $#ENSP00000277554#ENSG00000148411#ENST00000277554#Other#BEN, BTB$#ENSP00000360818#ENSG00000148411#ENST00000371753#Other#BEN, BTB FALSE 2242 ENSG00000266412 NCOA4 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR022174 8031 nuclear receptor coactivator 4 [Source:HGNC Symbol;Acc:HGNC:7671] None not tested not tested None None No No TF Gene_Transcription Factor Binding: tf co-factor binding_Co-activation_PMIDS:8643607 No 5a, one of the source datasets predicts is as a TF Sam Lambert Yimeng Yin No None $##ENSG00000266412##Other# FALSE 2243 ENSG00000124160 NCOA5 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Known coactivator with no DBD IPR004154 57727 nuclear receptor coactivator 5 [Source:HGNC Symbol;Acc:HGNC:15909] None not tested not tested None None No No TF Gene_Transcription Factor Binding: tf co-factor binding_Co-activation_PMIDS:11113208 No 5a, one of the source datasets predicts is as a TF Matt Weirauch Tim Hughes No None $##ENSG00000124160##Other# FALSE 2244 ENSG00000198646 NCOA6 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Protein is a transcriptional co-regulator (PMID: 10681503) None 23054 nuclear receptor coactivator 6 [Source:HGNC Symbol;Acc:HGNC:15936] None not tested not tested None None No No TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_TF PPI; Transactivation_PMIDS:10681503 No 5a, one of the source datasets predicts is as a TF Pratyush Das Arttu Jolma No None $##ENSG00000198646##Other# FALSE 2245 ENSG00000111912 NCOA7 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Known co-activator; included only because TF-cat documents this IPR006571;IPR018392 135112 nuclear receptor coactivator 7 [Source:HGNC Symbol;Acc:HGNC:21081] None not tested not tested None None No No TF Gene_Transcription Factor Binding: tf co-factor binding_Co-activation_PMIDS:11971969 No 5a, one of the source datasets predicts is as a TF Tim Hughes Matt Weirauch No None $##ENSG00000111912##Other# FALSE 2246 ENSG00000182636 NDN Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None None 4692 Necdin None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Yimeng Yin Pratyush Das No $#ENSG00000182636#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019 $##ENSG00000182636##Other# FALSE 2247 ENSG00000124479 NDP Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Included only because GO says positive regulation of sequence-specific DNA binding transcription factor activity. Not DNA binding. None 4693 Norrin None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Jussi Taipale Tim Hughes No $#ENSG00000124479#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019 $##ENSG00000124479##Other# FALSE 2248 ENSG00000140398 NEIL1 Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None DNA glycosylase 1. Binds DNA in the crystal structure (PDB: 5ITR) None None nei like DNA glycosylase 1 5ITR not tested not tested None DNA glycosylase 1. Binds DNA in the crystal structure (PDB: 5ITR) No No No No New proteins added based on PDB entry Arttu Jolma Sam Lambert No None None FALSE 2249 ENSG00000235568 NFAM1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None NFAM1 modulates B cell signaling through its immunoreceptor tyrosine-based activation motif, which regulates B cell development (PMID: 15143214) IPR003110 150372 NFAT activating protein with ITAM motif 1 [Source:HGNC Symbol;Acc:HGNC:29872] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Laura Campitelli Sam Lambert No $#ENSG00000235568#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:12615919 $#ENSP00000333680#ENSG00000235568#ENST00000329021#Other# FALSE 2250 ENSG00000230257 NFE4 Unknown Yes Known motif Obligate heteromer In vivo/Misc source None NFE4 does not posess a DBD. It is a member of the SSP complex that regulates B-globin gene expression, and binds DNA as a heteromer with CP2, based on EMSA (PMID: 7828600; PMID: 15273251). A shorter isoform prevents CP2 binding (PMID: 16263792) and is involved in repression. No gel-shift experiments have been performed in the absence of its partner, CP2, thus its likely an obligate heteromer. None None nuclear factor, erythroid 4 None not tested not tested None None No No No No New proteins added after initial stage None None No None None FALSE 2251 ENSG00000100906 NFKBIA Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None This is I kappa B alpha, which interacts with NFkappaB. No DBD, and evidence indicates that it is not a TF. IPR002110;IPR020683 4792 NFKB inhibitor alpha [Source:HGNC Symbol;Acc:HGNC:7797] None not tested not tested None None No No Not a TF - Evidence that it is not a TF__TF PPI_PMIDS:3140380;8717528 Yes 5a, one of the source datasets predicts is as a TF Matt Weirauch Tim Hughes Yes $#ENSG00000100906#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IDA - PMID:11931770$#ENSG00000100906#GO:0051092#positive regulation of NF-kappaB transcription factor activity#TAS - Reactome:R-HSA-445989 $#ENSP00000216797#ENSG00000100906#ENST00000216797#Other#Ank, Ank_2, Ank_3, Ank_4, Ank_5$#ENSP00000450514#ENSG00000100906#ENST00000557389#Other#Ank, Ank_2, Ank_3, Ank_4, Ank_5$#ENSP00000451281#ENSG00000100906#ENST00000553342#Other#$#ENSP00000451257#ENSG00000100906#ENST00000557140#Other#Ank, Ank_2, Ank_3, Ank_4, Ank_5 FALSE 2252 ENSG00000104825 NFKBIB Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None From (PMID: 12686541), it appears that the ternary complex is stabilized by an interaction with this protein, which suggests that this protein may offer a conducive electrostatic environment rather directly contributing to the binding event. IPR002110;IPR020683 4793 NFKB inhibitor beta [Source:HGNC Symbol;Acc:HGNC:7798] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Arttu Jolma Pratyush Das Yes $#ENSG00000104825#GO:0051092#positive regulation of NF-kappaB transcription factor activity#TAS - Reactome:R-HSA-445989 $#ENSP00000312988#ENSG00000104825#ENST00000313582#Other#Ank, Ank_2, Ank_3, Ank_4, Ank_5$#ENSP00000459728#ENSG00000104825#ENST00000572515#Other#Ank, Ank_2, Ank_3, Ank_4, Ank_5$#ENSP00000458685#ENSG00000104825#ENST00000575359#Other#Ank, Ank_2, Ank_3, Ank_4, Ank_5$#ENSP00000461617#ENSG00000104825#ENST00000576510#Other#Ank, Ank_2, Ank_3, Ank_4, Ank_5 FALSE 2253 ENSG00000167604 NFKBID Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None None 84807 NF-kappa-B inhibitor delta None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Sam Lambert Arttu Jolma Yes $#ENSG00000167604#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IEA - GO_REF:0000019 $##ENSG00000167604##Other# FALSE 2254 ENSG00000204498 NFKBIL1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR020683 None NFKB inhibitor like 1 [Source:HGNC Symbol;Acc:HGNC:7800] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Sam Lambert Laura Campitelli Yes None None FALSE 2255 ENSG00000144802 NFKBIZ Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR002110;IPR020683 64332 NFKB inhibitor zeta [Source:HGNC Symbol;Acc:HGNC:29805] None not tested not tested None None No No TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_DNA Binding; TF PPI; Transactivation_PMIDS:15241416 No 5a, one of the source datasets predicts is as a TF Sam Lambert Yimeng Yin Yes None $##ENSG00000144802##Other# FALSE 2256 ENSG00000170322 NFRKB Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Has a winged helix but cannot bind to the NFKB consensus. IPR025220; 4798 nuclear factor related to kappaB binding protein [Source:HGNC Symbol;Acc:HGNC:7802] None not tested not tested None None other No No No 5a, one of the source datasets predicts is as a TF Matt Weirauch Yimeng Yin No None $#ENSP00000436926#ENSG00000170322#ENST00000524794#Other#NFRKB_winged$#ENSP00000432520#ENSG00000170322#ENST00000526940#Other#$#ENSP00000431247#ENSG00000170322#ENST00000526884#Other#$#ENSP00000434326#ENSG00000170322#ENST00000529319#Other# FALSE 2257 ENSG00000120837 NFYB Unknown Yes Known motif Obligate heteromer In vivo/Misc source None Obligate heterotrimer of NFYA, NFYB, and NFYC IPR003956;IPR003958;IPR009072; 4801 nuclear transcription factor Y subunit beta [Source:HGNC Symbol;Acc:HGNC:7805] 4AWL DBD and Full not tested Obligate_Multimer Obligate heterotrimer a Yes TF Gene_Basal Transcription Factor_TF PPI_PMIDS:12401788 Yes 1a1, Direct HQ evidence Yimeng Yin Arttu Jolma Yes $#ENSG00000120837#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019 $#ENSP00000240055#ENSG00000120837#ENST00000240055#Other#CBFD_NFYB_HMF, CENP-T_C, Histone, TFIID-18kDa$#ENSP00000448250#ENSG00000120837#ENST00000551446#Other#CBFD_NFYB_HMF, CENP-T_C, Histone, TFIID-18kDa$#ENSP00000447486#ENSG00000120837#ENST00000551727#Other#CBFD_NFYB_HMF, CENP-T_C, Histone, TFIID-18kDa FALSE 2258 ENSG00000066136 NFYC Unknown Yes Known motif Obligate heteromer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain PDB 4AWL is a very tightly intertwined heterotrimeric complex of NFYA, NFYB and NFYC with a plenty of protein-protein interactions. NFYA contains the recognition alpha-helix but there is no point considering any of the components separately as they are definitely complexed even in the solution and all contribute contacts with the DNA backbone. IPR003958;IPR009072 4802 nuclear transcription factor Y subunit gamma [Source:HGNC Symbol;Acc:HGNC:7806] 4AWL DBD and Full not tested Obligate_Multimer Obligate heterotrimer a Yes TF Gene_DNA-Binding: sequence-specific__PMIDS:0 Yes 1a1, Direct HQ evidence Pratyush Das Tim Hughes Yes $#ENSG00000066136#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000066136#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:10446203, PMID:9332362 $#ENSP00000312617#ENSG00000066136#ENST00000308733#Other#CBFD_NFYB_HMF, Histone$#ENSP00000361738#ENSG00000066136#ENST00000372654#Other#CBFD_NFYB_HMF, Histone$#ENSP00000404427#ENSG00000066136#ENST00000447388#Other#CBFD_NFYB_HMF, Histone$#ENSP00000408867#ENSG00000066136#ENST00000456393#Other#CBFD_NFYB_HMF, Histone$#ENSP00000361736#ENSG00000066136#ENST00000372652#Other#CBFD_NFYB_HMF, Histone$#ENSP00000361737#ENSG00000066136#ENST00000372653#Other#CBFD_NFYB_HMF, Histone$#ENSP00000396620#ENSG00000066136#ENST00000425457#Other#CBFD_NFYB_HMF, Histone$#ENSP00000408315#ENSG00000066136#ENST00000427410#Other#CBFD_NFYB_HMF$#ENSP00000416403#ENSG00000066136#ENST00000414185#Other# FALSE 2259 ENSG00000186416 NKRF Unknown Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Binds AATTTCCTCTGA based on EMSA (PMID: 11071890) and to AATTCCCTGA based on another EMSA (PMID: 16107696) IPR000467;IPR001374;IPR014720; 55922 NFKB repressing factor [Source:HGNC Symbol;Acc:HGNC:19374] None Full not tested None None other No No No 5a, one of the source datasets predicts is as a TF Sam Lambert Arttu Jolma No None $#ENSP00000304803#ENSG00000186416#ENST00000304449#Other#G-patch, G-patch_2, R3H, dsrm$#ENSP00000360582#ENSG00000186416#ENST00000371527#Other#G-patch, G-patch_2, R3H, dsrm$#ENSP00000442308#ENSG00000186416#ENST00000542113#Other#G-patch, G-patch_2, R3H, dsrm FALSE 2260 ENSG00000167984 NLRC3 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR003590;IPR007111 197358 NLR family CARD domain containing 3 [Source:HGNC Symbol;Acc:HGNC:29889] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Sam Lambert Yimeng Yin No $#ENSG00000167984#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IDA - PMID:15705585 $#ENSP00000352039#ENSG00000167984#ENST00000359128#Other#LRR_4, LRR_6, LRR_8, NACHT$#ENSP00000482302#ENSG00000167984#ENST00000618137#Other#LRR_1, LRR_4, LRR_6, LRR_8$#ENSP00000323897#ENSG00000167984#ENST00000324659#Other#LRR_4, LRR_6, LRR_8, NACHT FALSE 2261 ENSG00000091106 NLRC4 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR001315;IPR007111;IPR011029;IPR027417 58484 NLR family CARD domain containing 4 [Source:HGNC Symbol;Acc:HGNC:16412] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Pratyush Das Jussi Taipale No $#ENSG00000091106#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IDA - PMID:12646168 $#ENSP00000339666#ENSG00000091106#ENST00000342905#Other#CARD$#ENSP00000354159#ENSG00000091106#ENST00000360906#Other#CARD, NACHT$#ENSP00000385428#ENSG00000091106#ENST00000402280#Other#CARD, NACHT$#ENSP00000385090#ENSG00000091106#ENST00000404025#Other#CARD, NACHT FALSE 2262 ENSG00000140853 NLRC5 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Protein inhibits NFKB activity IPR001611;IPR003590;IPR006553;IPR007111;IPR025875;IPR027417 84166 NLR family CARD domain containing 5 [Source:HGNC Symbol;Acc:HGNC:29933] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Laura Campitelli Arttu Jolma No $#ENSG00000140853#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IDA - PMID:20434986 $#ENSP00000442906#ENSG00000140853#ENST00000538805#Other#LRR_1, LRR_4, LRR_6, LRR_8, NACHT$#ENSP00000440184#ENSG00000140853#ENST00000399221#Other#LRR_6$#ENSP00000441311#ENSG00000140853#ENST00000538059#Other#$#ENSP00000439464#ENSG00000140853#ENST00000544641#Other# FALSE 2263 ENSG00000142405 NLRP12 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR001611;IPR003590;IPR004020;IPR007111;IPR011029;IPR027417;IPR029495 91662 NLR family pyrin domain containing 12 [Source:HGNC Symbol;Acc:HGNC:22938];NACHT, LRR and PYD domains None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Matt Weirauch Jussi Taipale No $#ENSG00000142405#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IDA - PMID:18230725 $#ENSP00000319377#ENSG00000142405#ENST00000324134#Other#FISNA, LRR_4, LRR_6, NACHT, PYRIN$#ENSP00000341428#ENSG00000142405#ENST00000345770#Other#FISNA, LRR_4, LRR_6, NACHT, PYRIN$#ENSP00000375652#ENSG00000142405#ENST00000391772#Other#FISNA, LRR_6, NACHT, PYRIN$#ENSP00000375653#ENSG00000142405#ENST00000391773#Other#FISNA, LRR_4, LRR_6, NACHT, PYRIN$#ENSP00000375655#ENSG00000142405#ENST00000391775#Other#FISNA, LRR_4, LRR_6, NACHT, PYRIN FALSE 2264 ENSG00000215174 NLRP2B Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR011029 286430 NLR family pyrin domain containing 2B [Source:HGNC Symbol;Acc:HGNC:29887];Pyrin domain-containing pr None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Yimeng Yin Laura Campitelli No $#ENSG00000215174#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IMP - PMID:24871464 $#ENSP00000488995#ENSG00000215174#ENST00000434992#Other#PYRIN FALSE 2265 ENSG00000162711 NLRP3 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Operates upstream in the signaling cascade IPR003590;IPR004020;IPR007111;IPR011029;IPR027417;IPR029495 114548 NLR family pyrin domain containing 3 [Source:HGNC Symbol;Acc:HGNC:16400] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Jussi Taipale Arttu Jolma No $#ENSG00000162711#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IDA - PMID:14662828$#ENSG00000162711#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IDA - PMID:19158675 $#ENSP00000337383#ENSG00000162711#ENST00000336119#Other#FISNA, LRR_4, LRR_6, NACHT, PYRIN$#ENSP00000294752#ENSG00000162711#ENST00000348069#Other#FISNA, LRR_4, LRR_6, NACHT, PYRIN$#ENSP00000355452#ENSG00000162711#ENST00000366496#Other#FISNA, LRR_4, LRR_6, NACHT, PYRIN$#ENSP00000355453#ENSG00000162711#ENST00000366497#Other#FISNA, LRR_4, LRR_6, NACHT, PYRIN$#ENSP00000375703#ENSG00000162711#ENST00000391827#Other#FISNA, LRR_4, LRR_6, NACHT, PYRIN$#ENSP00000375704#ENSG00000162711#ENST00000391828#Other#FISNA, LRR_4, LRR_6, NACHT, PYRIN FALSE 2266 ENSG00000243678 NME2 Unknown Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Binds to telomeres (PMID: 22135295). Binds specific sequences by gel-shift, and binding is impacted by a SNP (PMID: 23368879) IPR001564;IPR023005 None NME1-NME2 readthrough [Source:HGNC Symbol;Acc:HGNC:33531];Nucleoside diphosphate kinase B None not tested not tested None Binds to telomeres (PMID: 22135295). Binds specific sequences by gel-shift, and binding is impacted by a SNP (PMID: 23368879) No No No Yes 5a, one of the source datasets predicts is as a TF Matt Weirauch Pratyush Das No None None FALSE 2267 ENSG00000173145 NOC3L Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None No evidence to support a DNA binding function IPR005612;IPR011501;IPR016024;IPR016903 64318 NOC3 like DNA replication regulator [Source:HGNC Symbol;Acc:HGNC:24034] None not tested not tested None None c No No No 5a, one of the source datasets predicts is as a TF Pratyush Das Arttu Jolma No None $#ENSP00000360412#ENSG00000173145#ENST00000371361#Other#CBF, DUF2732, NOC3p FALSE 2268 ENSG00000184967 NOC4L Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Protein is associated with ribosome synthesis (PMID: 27798105) IPR005612;IPR016024 79050 nucleolar complex associated 4 homolog [Source:HGNC Symbol;Acc:HGNC:28461] None not tested not tested None None c No No No 5a, one of the source datasets predicts is as a TF Arttu Jolma Pratyush Das No None $#ENSP00000328854#ENSG00000184967#ENST00000330579#Other#CBF$#ENSP00000438255#ENSG00000184967#ENST00000541954#Other# FALSE 2269 ENSG00000151014 NOCT Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Deadenylase protein that probably regulates genes post-transcriptionally (PMID: 22073225) IPR005135 25819 nocturnin [Source:HGNC Symbol;Acc:HGNC:14254] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Sam Lambert Arttu Jolma No $#ENSG00000151014#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:10521507 $#ENSP00000280614#ENSG00000151014#ENST00000280614#Other#Exo_endo_phos, Exo_endo_phos_2 FALSE 2270 ENSG00000106100 NOD1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None NOD-proteins function in signaling cascades that report bacterial peptidoglycans. They activate kinases that in turn activate NFKB proteins etc. Reviewed in (PMID: 25526305) IPR001315;IPR003590;IPR007111;IPR011029 10392 nucleotide binding oligomerization domain containing 1 [Source:HGNC Symbol;Acc:HGNC:16390] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Arttu Jolma Matt Weirauch No $#ENSG00000106100#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IDA - PMID:17054981, PMID:19043560 | TAS - Reactom $#ENSP00000222823#ENSG00000106100#ENST00000222823#Other#AAA_16, AAA_18, CARD, LRR_4, LRR_6, NACHT$#ENSP00000396046#ENSG00000106100#ENST00000411552#Other#CARD$#ENSP00000399505#ENSG00000106100#ENST00000413433#Other#CARD$#ENSP00000410917#ENSG00000106100#ENST00000419601#Other#$#ENSP00000395551#ENSG00000106100#ENST00000419799#Other#CARD FALSE 2271 ENSG00000167207 NOD2 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR001315;IPR001611;IPR003590;IPR007111;IPR011029;IPR027417 64127 nucleotide binding oligomerization domain containing 2 [Source:HGNC Symbol;Acc:HGNC:5331] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Matt Weirauch Sam Lambert No $#ENSG00000167207#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IDA - PMID:11385577, PMID:12527755, PMID:21887730 $#ENSP00000431681#ENSG00000167207#ENST00000531674#Other#CARD$#ENSP00000437246#ENSG00000167207#ENST00000534057#Other#LRR_4, LRR_6, LRR_8$#ENSP00000300589#ENSG00000167207#ENST00000300589#Other#AAA_16, AAA_22, AAA_29, CARD, LRR_4, LRR_6, LRR_8, FALSE 2272 ENSG00000156574 NODAL Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Protein is a secreted signaling molecule IPR001111;IPR001839;IPR017948;IPR029034 4838 nodal growth differentiation factor [Source:HGNC Symbol;Acc:HGNC:7865] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Sam Lambert Arttu Jolma No $#ENSG00000156574#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IMP - PMID:21116837 $#ENSP00000287139#ENSG00000156574#ENST00000287139#Other#TGF_beta, TGFb_propeptide$#ENSP00000394468#ENSG00000156574#ENST00000414871#Other#TGF_beta, TGFb_propeptide FALSE 2273 ENSG00000147140 NONO Unknown No ssDNA/RNA binding Not a DNA binding protein No motif None RBP with RRM domains None 4841 non-POU domain containing, octamer-binding [Source:HGNC Symbol;Acc:HGNC:7871] None not tested not tested None None No No No No 2a1, Lower confidence direct evidence Pratyush Das Arttu Jolma Yes None $##ENSG00000147140##Other# FALSE 2274 ENSG00000111641 NOP2 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR001678;IPR011023;IPR012586;IPR018314;IPR023267;IPR023273;IPR029063 4839 NOP2 nucleolar protein [Source:HGNC Symbol;Acc:HGNC:7867] None not tested not tested None None No No Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0 No 5a, one of the source datasets predicts is as a TF Laura Campitelli Pratyush Das No None $##ENSG00000111641##Other# FALSE 2275 ENSG00000148400 NOTCH1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None A transmembrane protein that inhibits MEF2C activation (PMID: 10082551). NOTCH1 does not bind DNA in the structure, and is not required for DNA binding, since RBPJ is bound without it in (PDB:4J2X). IPR000152;IPR000742;IPR000800;IPR001881;IPR002110;IPR008297;IPR009030;IPR010660;IPR011656;IPR013032;IPR018097; 4851 notch 1 [Source:HGNC Symbol;Acc:HGNC:7881] 2F8X not tested Yes None NOTCH1 does not contact DNA in the structure No No TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_TF PPI; Transactivation_PMIDS:10082551;15991363 No 5a, one of the source datasets predicts is as a TF Arttu Jolma Yimeng Yin No $#ENSG00000148400#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019 $##ENSG00000148400##Other# FALSE 2276 ENSG00000134250 NOTCH2 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Transmembrane receptor protein that operates far upstream in the signaling cascade IPR000152;IPR000742;IPR000800;IPR001881;IPR002110;IPR008297;IPR009030;IPR010660;IPR011656;IPR013032;IPR018097; 4853 notch 2 [Source:HGNC Symbol;Acc:HGNC:7882] None not tested Yes None None No No TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_Other_PMIDS:15134786 No 5a, one of the source datasets predicts is as a TF Matt Weirauch Arttu Jolma No None $##ENSG00000134250##Other# FALSE 2277 ENSG00000074181 NOTCH3 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Fragment of NOTCH. Is a coactivator. IPR000152;IPR000742;IPR000800;IPR001881;IPR002110;IPR008297;IPR009030;IPR010660;IPR011656;IPR013032;IPR018097; 4854 notch 3 [Source:HGNC Symbol;Acc:HGNC:7883] None not tested Yes None None No No TF Gene_Transcription Factor Binding: tf co-factor binding_Co-activation; Transactivation_PMIDS:16365048 No 5a, one of the source datasets predicts is as a TF Matt Weirauch Jussi Taipale No None $##ENSG00000074181##Other# FALSE 2278 ENSG00000181163 NPM1 Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None No evidence for sequence-specific DNA-binding (PMID: 2223875) IPR024057 4869 nucleophosmin (nucleolar phosphoprotein B23, numatrin) [Source:HGNC Symbol;Acc:HGNC:7910] None not tested not tested None None No No TF Gene_Transcription Factor Binding: tf co-factor binding; Single stranded RNA/DNA binding_Non-specific DNA_PMIDS:2223875;16107701 Yes 4a, two or more datasets predict it as a TF Sam Lambert Jussi Taipale No $#ENSG00000181163#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IMP - PMID:15087454 $#ENSP00000296930#ENSG00000181163#ENST00000296930#Other#NPM1-C, Nop14, Nucleoplasmin, SDA1$#ENSP00000341168#ENSG00000181163#ENST00000351986#Other#DUF2457, Drc1-Sld2, NPM1-C, Nucleoplasmin, SDA1$#ENSP00000377408#ENSG00000181163#ENST00000393820#Other#Nucleoplasmin, SDA1$#ENSP00000428755#ENSG00000181163#ENST00000517671#Other#NPM1-C, Nop14, Nucleoplasmin, SDA1$#ENSP00000428647#ENSG00000181163#ENST00000523622#Other#Nucleoplasmin FALSE 2279 ENSG00000169297 NR0B1 Unknown Yes Known motif Obligate heteromer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain None IPR000536;IPR001723;IPR008946;IPR025900 190 nuclear receptor subfamily 0 group B member 1 [Source:HGNC Symbol;Acc:HGNC:7960] None not tested not tested None None a Yes TF Gene_DNA-Binding: sequence-specific_TF PPI_PMIDS:16709599;9032275;9384387;10848616;11053406;11427738;9384387;12482977;15155786;15464421;9032275;9384387;9661652;10848616 Yes 2a1, Lower confidence direct evidence Sam Lambert Laura Campitelli Yes $#ENSG00000169297#GO:0004879#ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity#IDA - PMID:7990953 | NAS - PMID:9384387$#ENSG00000169297#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#IMP - PMID:19651776 $#ENSP00000368253#ENSG00000169297#ENST00000378970#Nuclear Hormone Receptor#Hormone_recep, NR_Repeat$#ENSP00000368246#ENSG00000169297#ENST00000378963#Nuclear Hormone Receptor#Hormone_recep FALSE 2280 ENSG00000131910 NR0B2 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Transcription cofactor - lacks a conventional DNA binding domain and represses the transcriptional activity of various nuclear receptors (PMID: 14752053) IPR000536;IPR001723;IPR008946; 8431 nuclear receptor subfamily 0 group B member 2 [Source:HGNC Symbol;Acc:HGNC:7961] None not tested not tested None None x No No Yes 4a, two or more datasets predict it as a TF Yimeng Yin Laura Campitelli Yes $#ENSG00000131910#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:14752053 $#ENSP00000254227#ENSG00000131910#ENST00000254227#Other#Hormone_recep FALSE 2281 ENSG00000106459 NRF1 Unknown Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR019525;IPR019526 4899 nuclear respiratory factor 1 [Source:HGNC Symbol;Acc:HGNC:7996] None DBD and Full not tested None None other Yes Indeterminate - There is no evidence for or against this genes role as a TF__DNA Binding; Transactivation_PMIDS:9580677 Yes 1a1, Direct HQ evidence Tim Hughes Sam Lambert Yes $#ENSG00000106459#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:19674972 | IMP - PMID:19674972 $#ENSP00000309826#ENSG00000106459#ENST00000311967#NRF#Nrf1_DNA-bind, Nrf1_activ_bdg$#ENSP00000376922#ENSG00000106459#ENST00000393230#NRF#Nrf1_DNA-bind, Nrf1_activ_bdg$#ENSP00000376924#ENSG00000106459#ENST00000393232#NRF#Nrf1_DNA-bind, Nrf1_activ_bdg FALSE 2282 ENSG00000157168 NRG1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Cell surface receptor - does not have predicted DBDs IPR000742;IPR002154;IPR003598;IPR003599;IPR007110;IPR013032;IPR013098;IPR018250 3084 neuregulin 1 [Source:HGNC Symbol;Acc:HGNC:7997] None not tested not tested None None No No TF Gene_Transcription Factor Binding: tf co-factor binding_Co-activation; DNA Binding_PMIDS:15494726;7559778;7589796;15494726;12529413;15494726;7816098;12649319;15073182;15494726;15498868 No 5a, one of the source datasets predicts is as a TF Arttu Jolma Yimeng Yin No None $##ENSG00000157168##Other# FALSE 2283 ENSG00000180530 NRIP1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Transcriptional cofactor None 8204 nuclear receptor interacting protein 1 [Source:HGNC Symbol;Acc:HGNC:8001] None not tested not tested None None No No TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_Co-activation_PMIDS:9774688 No 5a, one of the source datasets predicts is as a TF Laura Campitelli Arttu Jolma No None $##ENSG00000180530##Other# FALSE 2284 ENSG00000175352 NRIP3 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Binds indirectly to DNA through interactions with NHR TFs (PMID: 10860982) IPR019103;IPR021109 56675 nuclear receptor interacting protein 3 [Source:HGNC Symbol;Acc:HGNC:1167] None not tested not tested None None No No TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:10860982 No 5a, one of the source datasets predicts is as a TF Sam Lambert Arttu Jolma No None $##ENSG00000175352##Other# FALSE 2285 ENSG00000123572 NRK Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Protein is a kinase IPR000719;IPR001180;IPR002290;IPR008271;IPR011009;IPR017441 203447 Nik related kinase [Source:HGNC Symbol;Acc:HGNC:25391] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Matt Weirauch Arttu Jolma No None $#ENSP00000434830#ENSG00000123572#ENST00000243300#Other#CNH, Kdo, Kinase-like, Pkinase, Pkinase_Tyr$#ENSP00000438785#ENSG00000123572#ENST00000536164#Other#Pkinase, Pkinase_Tyr$#ENSP00000438148#ENSG00000123572#ENST00000540278#Other#CNH FALSE 2286 ENSG00000165671 NSD1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Protein is a histone methyltransferase with H3K36 and H4K20 methylation activities (PMID: 12805229) IPR000313;IPR001214;IPR001965;IPR003616;IPR006560;IPR011011;IPR019786;IPR019787 64324 nuclear receptor binding SET domain protein 1 [Source:HGNC Symbol;Acc:HGNC:14234] None not tested not tested None None No No TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_TF PPI; Transactivation_PMIDS:9628876;12805229 No 5a, one of the source datasets predicts is as a TF Laura Campitelli Arttu Jolma No None $##ENSG00000165671##Other# FALSE 2287 ENSG00000198400 NTRK1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Membrane bound receptor protein IPR000483;IPR000719;IPR001245;IPR001611;IPR002011;IPR007110;IPR008266;IPR011009;IPR017441;IPR020461;IPR020635; 4914 neurotrophic receptor tyrosine kinase 1 [Source:HGNC Symbol;Acc:HGNC:8031];High affinity nerve growt None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Pratyush Das Arttu Jolma No $#ENSG00000198400#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IDA - PMID:15488758 $#ENSP00000357179#ENSG00000198400#ENST00000368196#Other#I-set, Ig_2, Ig_3, LRR_8, Pkinase, Pkinase_Tyr, TP$#ENSP00000431418#ENSG00000198400#ENST00000524377#Other#I-set, Ig_2, Ig_3, LRR_8, Pkinase, Pkinase_Tyr, TP$#ENSP00000351486#ENSG00000198400#ENST00000358660#Other#I-set, Ig_2, Ig_3, LRR_8, Pkinase, Pkinase_Tyr, TP$#ENSP00000376120#ENSG00000198400#ENST00000392302#Other#I-set, Ig_2, Ig_3, LRR_8, Pkinase, Pkinase_Tyr, TP FALSE 2288 ENSG00000069275 NUCKS1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Contains a GRP core, which is similar to an AT-hook. But, the amino acids flanking the core are quite different from an AT-hook. Could non-specifically bind to DNA, but lacks compelling evidence. None 64710 Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Jussi Taipale Yimeng Yin No $#ENSG00000069275#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019 $##ENSG00000069275##Other# FALSE 2289 ENSG00000110713 NUP98 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR007230;IPR021967 4928 nucleoporin 98 [Source:HGNC Symbol;Acc:HGNC:8068] None not tested not tested None None No No Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0 No 5a, one of the source datasets predicts is as a TF Laura Campitelli Jussi Taipale No None $##ENSG00000110713##Other# FALSE 2290 ENSG00000114026 OGG1 Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None DNA error repairing enzyme. Binds DNA in the crystal structure (PDB: 1EBM), presumably without specificity None None 8-oxoguanine DNA glycosylase 1EBM not tested not tested None DNA error repairing enzyme. Binds DNA in the crystal structure (PDB: 1EBM), presumably without specificity No No No No New proteins added based on PDB entry Arttu Jolma Sam Lambert No None None FALSE 2291 ENSG00000116329 OPRD1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Transmembrane protein IPR000276;IPR000321;IPR001418;IPR017452 4985 opioid receptor delta 1 [Source:HGNC Symbol;Acc:HGNC:8153] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Matt Weirauch Arttu Jolma No $#ENSG00000116329#GO:0032793#positive regulation of CREB transcription factor activity#IC - PMID:24613828 $#ENSP00000234961#ENSG00000116329#ENST00000234961#Other#7TM_GPCR_Srsx, 7TM_GPCR_Srv, 7TM_GPCR_Srx, 7tm_1, $#ENSP00000477970#ENSG00000116329#ENST00000621425#Other#7TM_GPCR_Srsx, 7TM_GPCR_Srx, 7tm_1, 7tm_4 FALSE 2292 ENSG00000182938 OTOP3 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR004878;IPR007087 347741 otopetrin 3 [Source:HGNC Symbol;Acc:HGNC:19658] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Pratyush Das Jussi Taipale No None $#ENSP00000328090#ENSG00000182938#ENST00000328801#Other#Otopetrin FALSE 2293 ENSG00000154124 OTULIN Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR023235;IPR023237 90268 OTU deubiquitinase with linear linkage specificity [Source:HGNC Symbol;Acc:HGNC:25118];Ubiquitin thi None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Arttu Jolma Matt Weirauch No $#ENSG00000154124#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IDA - PMID:23746843, PMID:24726327, PMID:27559085 $#ENSP00000284274#ENSG00000154124#ENST00000284274#Other#Peptidase_C101, Peptidase_C65$#ENSP00000424966#ENSG00000154124#ENST00000506417#Other#Peptidase_C101 FALSE 2294 ENSG00000170515 PA2G4 Unknown Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Binds CGGCAAAAAGG repeats based on EMSA performed with recombinant E.Coli expressed protein (PMID: 1507318) IPR000994;IPR004545;IPR018349 5036 proliferation-associated 2G4 [Source:HGNC Symbol;Acc:HGNC:8550] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Laura Campitelli Arttu Jolma No $#ENSG00000170515#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:15073182 $#ENSP00000302886#ENSG00000170515#ENST00000303305#Other#Peptidase_M24$#ENSP00000447389#ENSG00000170515#ENST00000551061#Other#Peptidase_M24$#ENSP00000447615#ENSG00000170515#ENST00000553057#Other#Peptidase_M24$#ENSP00000448557#ENSG00000170515#ENST00000552766#Other#Peptidase_M24 FALSE 2295 ENSG00000100836 PABPN1 Unknown No ssDNA/RNA binding Not a DNA binding protein No motif None None IPR000504 8106 poly(A) binding protein nuclear 1 [Source:HGNC Symbol;Acc:HGNC:8565] None not tested not tested None None No No TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:11371506 No 5a, one of the source datasets predicts is as a TF Yimeng Yin Laura Campitelli No None $##ENSG00000100836##Other# FALSE 2296 ENSG00000116288 PARK7 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Operates upstream in the signaling cascade IPR002818;IPR006287;IPR029062 11315 Parkinsonism associated deglycase [Source:HGNC Symbol;Acc:HGNC:16369] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Arttu Jolma Pratyush Das No $#ENSG00000116288#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IMP - PMID:17015834 | TAS - PMID:22492997$#ENSG00000116288#GO:2000825#positive regulation of androgen receptor activity#IMP - PMID:17510388 $#ENSP00000340278#ENSG00000116288#ENST00000338639#Other#DJ-1_PfpI, GATase_3, ThiJ_like$#ENSP00000418770#ENSG00000116288#ENST00000493678#Other#DJ-1_PfpI, GATase_3, ThiJ_like$#ENSP00000466242#ENSG00000116288#ENST00000377493#Other#DJ-1_PfpI$#ENSP00000366708#ENSG00000116288#ENST00000377488#Other#DJ-1_PfpI, GATase_3, ThiJ_like$#ENSP00000366711#ENSG00000116288#ENST00000377491#Other#DJ-1_PfpI, GATase_3, ThiJ_like$#ENSP00000466756#ENSG00000116288#ENST00000469225#Other#DJ-1_PfpI, GATase_3 FALSE 2297 ENSG00000143799 PARP1 Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein In vivo/Misc source None DNA repair protein that binds dsDNA non-specifically (PMID: 21183686; PMID: 21262234). The Transfac motifs are likely NFAT target sites IPR001357;IPR001510;IPR004102;IPR008288;IPR008893;IPR012317;IPR012982 142 poly(ADP-ribose) polymerase 1 [Source:HGNC Symbol;Acc:HGNC:270] 2N8A not tested not tested None Structure has dsDNA with a single strand break, presumably non sequence-specific interaction No Yes TF Gene Candidate_DNA-Binding: non-sequence-specific; Transcription Regulatory Activity: heterochromatin interaction/binding; DNA-Binding: sequence-specific; Transcription Factor Binding: tf co-factor No 2a1, Lower confidence direct evidence Yimeng Yin Arttu Jolma No None $#ENSP00000355759#ENSG00000143799#ENST00000366794#Other#BRCT, BRCT_2, PADR1, PARP, PARP_reg, WGR, zf-PARP$#ENSP00000355755#ENSG00000143799#ENST00000366790#Other#zf-PARP$#ENSP00000355757#ENSG00000143799#ENST00000366792#Other#zf-PARP$#ENSP00000485852#ENSG00000143799#ENST00000629232#Other#zf-PARP FALSE 2298 ENSG00000178685 PARP10 Unknown No ssDNA/RNA binding Not a DNA binding protein No motif None Contains two RRM domains, so likely an RNA-binding protein. Myc-interacting factor capable of ADP-ribosylating itself and core histones (PMID: 15674325). IPR012317 84875 poly(ADP-ribose) polymerase family member 10 [Source:HGNC Symbol;Acc:HGNC:25895] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Sam Lambert Laura Campitelli No $#ENSG00000178685#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IMP - PMID:23575687 $#ENSP00000325618#ENSG00000178685#ENST00000313028#Other#PARP$#ENSP00000314320#ENSG00000178685#ENST00000313059#Other#$#ENSP00000434776#ENSG00000178685#ENST00000525773#Other#PARP$#ENSP00000431818#ENSG00000178685#ENST00000528625#Other#$#ENSP00000436301#ENSG00000178685#ENST00000525879#Other# FALSE 2299 ENSG00000177425 PAWR Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Protein that binds to several TFs such as PITX2 (PMID: 19801652) and appears to inactivate them None 5074 pro-apoptotic WT1 regulator [Source:HGNC Symbol;Acc:HGNC:8614] None Full not tested None None other No Probably Not a TF - No evidence that it is a TF___PMIDS:0 No 5a, one of the source datasets predicts is as a TF Arttu Jolma Pratyush Das No None $#ENSP00000328088#ENSG00000177425#ENST00000328827#Other#ATG16, FPP, IncA$#ENSP00000449928#ENSG00000177425#ENST00000552637#Other#$#ENSP00000447454#ENSG00000177425#ENST00000548426#Other#$#ENSP00000448317#ENSG00000177425#ENST00000551712#Other# FALSE 2300 ENSG00000159086 PAXBP1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Has been shown to associate with PAX3 and PAX7, and recruits H3K4 methyltransferase complex (PMID: 22862948). Has a putative DNA-binding domain, so it could contribute to specificity or even function as an independent TF None 94104 PAX3- and PAX7-binding protein 1 None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Matt Weirauch Arttu Jolma No $#ENSG00000159086#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IBA - GO_REF:0000033 $##ENSG00000159086##Other# FALSE 2301 ENSG00000157212 PAXIP1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Transcriptional coactivator that associates with PAX2 (PMID: 10908331) IPR001357 22976 PAX interacting protein 1 [Source:HGNC Symbol;Acc:HGNC:8624] None not tested not tested None None No No TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:10908331 No 5a, one of the source datasets predicts is as a TF Arttu Jolma Pratyush Das No None $##ENSG00000157212##Other# FALSE 2302 ENSG00000166228 PCBD1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Coactivator for HNF1A-dependent transcription. Regulates the dimerization of homeodomain protein HNF1A and enhances its transcriptional activity (UniProt: P61457) IPR001533 5092 pterin-4 alpha-carbinolamine dehydratase 1 [Source:HGNC Symbol;Acc:HGNC:8646] None not tested not tested None None No No TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:1763325 No 5a, one of the source datasets predicts is as a TF Yimeng Yin Laura Campitelli No None $##ENSG00000166228##Other# FALSE 2303 ENSG00000169564 PCBP1 Unknown No ssDNA/RNA binding Not a DNA binding protein No motif None Crystal structure shows it binds ssDNA (PDB: 1ZTG). IPR004087;IPR004088 5093 poly(rC) binding protein 1 [Source:HGNC Symbol;Acc:HGNC:8647] 1ZTG not tested not tested None The structure is with single-stranded DNA No No TF Gene Candidate_Single stranded RNA/DNA binding_Transactivation_PMIDS:2233727 No 5a, one of the source datasets predicts is as a TF Matt Weirauch Jussi Taipale No $#ENSG00000169564#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IEA - GO_REF:0000019 $##ENSG00000169564##Other# FALSE 2304 ENSG00000197111 PCBP2 Unknown No ssDNA/RNA binding Not a DNA binding protein No motif None Protein is an RBP. Structure (PDB:2PQU) is with single stranded DNA IPR004087;IPR004088 5094 poly(rC) binding protein 2 [Source:HGNC Symbol;Acc:HGNC:8648] 2PQU not tested not tested None Structure is with single stranded DNA No No TF Gene Candidate_Single stranded RNA/DNA binding_DNA Binding_PMIDS:8650178;16186123 No 5a, one of the source datasets predicts is as a TF Pratyush Das Arttu Jolma No None $##ENSG00000197111##Other# FALSE 2305 ENSG00000183570 PCBP3 Unknown No ssDNA/RNA binding Not a DNA binding protein No motif None KH domain suggests that this is an RNA-binding protein IPR004087;IPR004088 54039 poly(rC) binding protein 3 [Source:HGNC Symbol;Acc:HGNC:8651] None not tested not tested None None No No Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0 No 5a, one of the source datasets predicts is as a TF Sam Lambert Yimeng Yin No $#ENSG00000183570#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IEA - GO_REF:0000019 $##ENSG00000183570##Other# FALSE 2306 ENSG00000277258 PCGF2 Unknown Yes Likely to be sequence specific TF Monomer or homomultimer No motif None (PMID: 8521824) shows via SELEX and EMSA that the recombinant PCGF2 protein binds GACT repeats IPR001841;IPR017907;IPR018957 7703 polycomb group ring finger 2 [Source:HGNC Symbol;Acc:HGNC:12929] None not tested not tested None None No No TF Gene Candidate__Transactivation_PMIDS:17151361 No 5a, one of the source datasets predicts is as a TF Pratyush Das Arttu Jolma No None $##ENSG00000277258##Other# FALSE 2307 ENSG00000156374 PCGF6 Unknown Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Binds GACTNGACT based on SELEX and EMSA performed in (PMID: 8521824) IPR001841;IPR017907;IPR018957;IPR029071 84108 polycomb group ring finger 6 [Source:HGNC Symbol;Acc:HGNC:21156] None not tested not tested None None other No TF Gene Candidate_Transcription Regulatory Activity: heterochromatin interaction/binding_TF PPI_PMIDS:10500182;12167161 Yes 4a, two or more datasets predict it as a TF Laura Campitelli Arttu Jolma No $#ENSG00000156374#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IEA - GO_REF:0000019$#ENSG00000156374#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:8521824 $#ENSP00000338845#ENSG00000156374#ENST00000337211#Other#RAWUL, zf-C3HC4, zf-C3HC4_2, zf-C3HC4_3, zf-C3HC4_$#ENSP00000358862#ENSG00000156374#ENST00000369847#Other#RAWUL, zf-C3HC4, zf-C3HC4_2, zf-C3HC4_3, zf-RING_1 FALSE 2308 ENSG00000132646 PCNA Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None Binds DNA in the crystal structure (PDB: 5L7C). Protein barely contacts the DNA at all None None proliferating cell nuclear antigen 5L7C not tested not tested None Binds DNA in the crystal structure (PDB: 5L7C). Protein barely contacts the DNA at all No No Not a TF - Evidence that it is not a TF___PMIDS:0 No New proteins added based on PDB entry Arttu Jolma Sam Lambert No None None FALSE 2309 ENSG00000140479 PCSK6 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000209;IPR000742;IPR002884;IPR006212;IPR008979;IPR009020;IPR009030;IPR010909;IPR015500;IPR022398;IPR023827; 5046 proprotein convertase subtilisin/kexin type 6 [Source:HGNC Symbol;Acc:HGNC:8569] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Arttu Jolma Pratyush Das No None $#ENSP00000381246#ENSG00000140479#ENST00000398185#Other#Furin-like_2, GF_recep_IV, PLAC, P_proprotein, Pep$#ENSP00000482760#ENSG00000140479#ENST00000611716#Other#Furin-like_2, GF_recep_IV, PLAC, P_proprotein, Pep$#ENSP00000477768#ENSG00000140479#ENST00000611967#Other#P_proprotein, Peptidase_S8, S8_pro-domain$#ENSP00000479496#ENSG00000140479#ENST00000618548#Other#Furin-like_2, GF_recep_IV, PLAC, P_proprotein, Pep$#ENSP00000482831#ENSG00000140479#ENST00000619160#Other#Furin-like_2, GF_recep_IV, P_proprotein, Peptidase$#ENSP00000481556#ENSG00000140479#ENST00000622483#Other#Furin-like_2, GF_recep_IV, P_proprotein, Peptidase$#ENSP00000452839#ENSG00000140479#ENST00000558864#Other#VSP$#ENSP00000483048#ENSG00000140479#ENST00000621185#Other#P_proprotein$#ENSP00000453771#ENSG00000140479#ENST00000558951#Other#P_proprotein$#ENSP00000453155#ENSG00000140479#ENST00000559605#Other#Furin-like_2, GF_recep_IV FALSE 2310 ENSG00000090470 PDCD7 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None No DBD. No evidence for sequence-specific DNA binding. Included only because TFcat says its a cofactor. None 10081 programmed cell death 7 [Source:HGNC Symbol;Acc:HGNC:8767] None not tested not tested None None No No TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_Other_PMIDS:10037816 No 5a, one of the source datasets predicts is as a TF Tim Hughes Yimeng Yin No None $##ENSG00000090470##Other# FALSE 2311 ENSG00000083642 PDS5B Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif Has a putative AT-hook None IPR016024; 23047 PDS5 cohesin associated factor B [Source:HGNC Symbol;Acc:HGNC:20418] None Full not tested None None x No No No 5a, one of the source datasets predicts is as a TF Jussi Taipale Laura Campitelli No None $#ENSP00000313851#ENSG00000083642#ENST00000315596#Other#Cnd1, HEAT$#ENSP00000407005#ENSG00000083642#ENST00000447833#Other# FALSE 2312 ENSG00000197329 PELI1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Ubiquitin ligase None 57162 E3 ubiquitin-protein ligase pellino homolog 1 None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Yimeng Yin Arttu Jolma No $#ENSG00000197329#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IEA - GO_REF:0000019 $##ENSG00000197329##Other# FALSE 2313 ENSG00000179094 PER1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Protein that associates with CLOCK-ARNTL heterodimers to silence the expression of their target genes (PMID: 16987893) IPR000014;IPR022728 102465532 period circadian clock 1 [Source:HGNC Symbol;Acc:HGNC:8845] None not tested not tested None None No No TF Gene Candidate__Other_PMIDS:9856465 No 5a, one of the source datasets predicts is as a TF Arttu Jolma Laura Campitelli No None $##ENSG00000179094##Other# FALSE 2314 ENSG00000132326 PER2 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Protein that operates in the circadian clock through binding to and inhibiting the ARNTL-CLOCK heterodimer. Does not bind DNA itself )PMID: 16987893) IPR000014;IPR022728 8864 period circadian clock 2 [Source:HGNC Symbol;Acc:HGNC:8846] None not tested not tested None None No No TF Gene Candidate__Transactivation_PMIDS:15269772 No 5a, one of the source datasets predicts is as a TF Jussi Taipale Arttu Jolma No None $##ENSG00000132326##Other# FALSE 2315 ENSG00000049246 PER3 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000014;IPR022728 8863 period circadian clock 3 [Source:HGNC Symbol;Acc:HGNC:8847] None not tested not tested None None No No Indeterminate - There is no evidence for or against this genes role as a TF__TF PPI_PMIDS:14701732 No 5a, one of the source datasets predicts is as a TF Sam Lambert Tim Hughes No None $##ENSG00000049246##Other# FALSE 2316 ENSG00000142655 PEX14 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR006785 5195 peroxisomal biogenesis factor 14 [Source:HGNC Symbol;Acc:HGNC:8856] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Jussi Taipale Matt Weirauch No $#ENSG00000142655#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:11863372 $#ENSP00000349016#ENSG00000142655#ENST00000356607#Other#DUF948, HemX, Pex14_N$#ENSP00000465473#ENSG00000142655#ENST00000491661#Other#Pex14_N FALSE 2317 ENSG00000113068 PFDN1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR002777;IPR009053 5201 prefoldin subunit 1 [Source:HGNC Symbol;Acc:HGNC:8866] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Laura Campitelli Jussi Taipale No $#ENSG00000113068#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:8744932 $#ENSP00000261813#ENSG00000113068#ENST00000261813#Other#Prefoldin_2$#ENSP00000426383#ENSG00000113068#ENST00000510217#Other#$#ENSP00000428707#ENSG00000113068#ENST00000524074#Other#Prefoldin_2 FALSE 2318 ENSG00000137338 PGBD1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None PiggyBac Transposable Element Derived 1. Contains a SCAN domain and interacts with other SCAN proteins (see Q96JS3). Interpro also lists without ref that it has sequence specific DNA binding activity (IEA code). No concrete evidence available. IPR001190;IPR003309;IPR008916;IPR029526 84547 piggyBac transposable element derived 1 [Source:HGNC Symbol;Acc:HGNC:19398] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Pratyush Das Sam Lambert No $#ENSG00000137338#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000259883#ENSG00000137338#ENST00000259883#Other#DDE_Tnp_1_7, SCAN FALSE 2319 ENSG00000087157 PGS1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR001736;IPR016270;IPR025202 9489 phosphatidylglycerophosphate synthase 1 [Source:HGNC Symbol;Acc:HGNC:30029] None not tested not tested None None No No TF Gene Candidate_DNA-Binding: sequence-specific_DNA Binding_PMIDS:10432290 No 5a, one of the source datasets predicts is as a TF Tim Hughes Pratyush Das No None $##ENSG00000087157##Other# FALSE 2320 ENSG00000167085 PHB Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Protein is likely a mitochondrial chaperone and thus its roles associated with transcription are likely to be very indirect (PMID: 10835343) None 5245 Prohibitin None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Sam Lambert Arttu Jolma No $#ENSG00000167085#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IEA - GO_REF:0000019 $##ENSG00000167085##Other# FALSE 2321 ENSG00000215021 PHB2 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Protein has been shown to bind to TFs and function as a co-repressor. There appears to be no evidence for direct DNA-binding activity (PMID: 18629613) IPR000163;IPR001107 11331 prohibitin 2 [Source:HGNC Symbol;Acc:HGNC:30306] None not tested not tested None None other No TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:10359819;15173318 Yes 4a, two or more datasets predict it as a TF Sam Lambert Arttu Jolma No $#ENSG00000215021#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#IMP - PMID:18629613$#ENSG00000215021#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:18629613 $#ENSP00000382362#ENSG00000215021#ENST00000399433#Other#Band_7, Med2$#ENSP00000438634#ENSG00000215021#ENST00000546111#Other# FALSE 2322 ENSG00000112511 PHF1 Unknown Yes Known motif Monomer or homomultimer High-throughput in vitro None Recent study (PMID: 28869966) demonstrates direct, specific DNA binding to CG-rich sequences through PBMs, and crystal structure in complex with DNA IPR001965;IPR002999;IPR011011;IPR019786;IPR019787;IPR025894 None PHD finger protein 1 [Source:HGNC Symbol;Acc:HGNC:8919] None not tested not tested None Recent study (PMID: 28869966) demonstrates direct, specific DNA binding to CG-rich sequences through PBMs, and crystal structure in complex with DNA No No No Yes 5a, one of the source datasets predicts is as a TF Laura Campitelli Yimeng Yin No None None FALSE 2323 ENSG00000119403 PHF19 Unknown Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Recent study (PMID: 28869966) demonstrates direct, specific DNA binding to CG-rich sequences of related proteins through PBMs, and crystal structure in complex with DNA None None PHD finger protein 19 None not tested not tested None Recent study (PMID: 28869966) demonstrates direct, specific DNA binding to CG-rich sequences of related proteins through PBMs, and crystal structure in complex with DNA No No No No New proteins added after initial stage None None No None None FALSE 2324 ENSG00000100410 PHF5A Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None This is a known spliceosomal protein with a PhD domain. I dont see the evidence that it binds the GJA1/Cx43 promoter, as listed on GeneCards. The reference cited does not mention this protein as far as I can see. In any case, binding could be indirect - the most likely role in transcription for a PHD domain protein would be as a cofactor. IPR005345 84844 PHD finger protein 5A [Source:HGNC Symbol;Acc:HGNC:18000] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Laura Campitelli Sam Lambert Yes $#ENSG00000100410#GO:0003700#sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024 $#ENSP00000216252#ENSG00000100410#ENST00000216252#Other#PHF5 FALSE 2325 ENSG00000116793 PHTF1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Despite its name, does not have a detectable Homeodomain. No available evidence for DNA binding. IPR021980 10745 putative homeodomain transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:8939] None not tested not tested None None No No Probably Not a TF - No evidence that it is a TF__Other_PMIDS:12604659;15601915 Yes 5a, one of the source datasets predicts is as a TF Pratyush Das Laura Campitelli Yes $#ENSG00000116793#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:10729229 $#ENSP00000350428#ENSG00000116793#ENST00000357783#Other#Phtf-FEM1B_bdg$#ENSP00000377025#ENSG00000116793#ENST00000393357#Other#Phtf-FEM1B_bdg$#ENSP00000416810#ENSG00000116793#ENST00000412670#Other#$#ENSP00000404690#ENSG00000116793#ENST00000446739#Other#Phtf-FEM1B_bdg FALSE 2326 ENSG00000006576 PHTF2 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Contains a Transcription factor homeodomain, male germ-cell domain (INTERPRO:IPR021980, PFAM:PF12129) that does not have any known DNA-binding activity. Its name comes from a fly ortholog that does contain a homeobox; but, the human gene does not. None None Putative homeodomain transcription factor 2 None not tested not tested None None No No No No New proteins added after initial stage None None No None None FALSE 2327 ENSG00000033800 PIAS1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None The protein contains a SAP motif, which has been annotated as a putative DNA-binding motif without supporting experimental evidence (PMID:10694879) IPR003034;IPR004181;IPR023321 8554 protein inhibitor of activated STAT 1 [Source:HGNC Symbol;Acc:HGNC:2752] None not tested not tested None None No No TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:9724754 No 5a, one of the source datasets predicts is as a TF Yimeng Yin Jussi Taipale No None $##ENSG00000033800##Other# FALSE 2328 ENSG00000078043 PIAS2 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Sumoylates transcription factors to modulate their activities (PMID: 22406621; PMID: 15976810; PMID: 15920481) IPR003034;IPR004181;IPR023321 9063 protein inhibitor of activated STAT 2 [Source:HGNC Symbol;Acc:HGNC:17311];E3 SUMO-protein ligase PIA None not tested not tested None None No No TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_Co-activation; TF PPI_PMIDS:12193603;12840021 Yes 4a, two or more datasets predict it as a TF Laura Campitelli Jussi Taipale No None $#ENSP00000317163#ENSG00000078043#ENST00000324794#Other#PINIT, zf-MIZ, zf-Nse$#ENSP00000465676#ENSG00000078043#ENST00000585916#Other#PINIT, zf-MIZ, zf-Nse$#ENSP00000443238#ENSG00000078043#ENST00000545673#Other#zf-MIZ, zf-Nse$#ENSP00000468166#ENSG00000078043#ENST00000586953#Other#SAP FALSE 2329 ENSG00000131788 PIAS3 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None PIAS-proteins regulate transcription factors by sumoylating them (PMID: 12077349) IPR003034;IPR004181;IPR023321 10401 protein inhibitor of activated STAT 3 [Source:HGNC Symbol;Acc:HGNC:16861] None not tested not tested None None No No TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:11709556 No 5a, one of the source datasets predicts is as a TF Pratyush Das Arttu Jolma No None $##ENSG00000131788##Other# FALSE 2330 ENSG00000105229 PIAS4 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None No DBD. No evidence of DNA binding - its a known cofactor IPR003034;IPR004181;IPR023321 51588 protein inhibitor of activated STAT 4 [Source:HGNC Symbol;Acc:HGNC:17002] None not tested not tested None None No No TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:11388671 No 5a, one of the source datasets predicts is as a TF Jussi Taipale Tim Hughes No $#ENSG00000105229#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IEA - GO_REF:0000019 $##ENSG00000105229##Other# FALSE 2331 ENSG00000177595 PIDD1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Operates upstream in the NFKB signaling cascade IPR000488;IPR000906;IPR001611;IPR003591;IPR011029;IPR019502 55367 p53-induced death domain protein 1 [Source:HGNC Symbol;Acc:HGNC:16491] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Jussi Taipale Arttu Jolma No $#ENSG00000177595#GO:0051092#positive regulation of NF-kappaB transcription factor activity#TAS - PMID:18309324 $#ENSP00000337797#ENSG00000177595#ENST00000347755#Other#Death, LRR_1, LRR_4, LRR_8, Peptidase_S68, ZU5$#ENSP00000416801#ENSG00000177595#ENST00000411829#Other#Death, LRR_1, LRR_4, LRR_8, Peptidase_S68, ZU5 FALSE 2332 ENSG00000115020 PIKFYVE Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Included only because its in Vasquerizas 2009 with an x. No DBD and no other evidence of DNA binding. IPR000306;IPR000591;IPR002423;IPR002498;IPR011011;IPR016034;IPR017455;IPR027409 200576 phosphoinositide kinase, FYVE-type zinc finger containing [Source:HGNC Symbol;Acc:HGNC:23785] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Tim Hughes Pratyush Das No None $#ENSP00000264380#ENSG00000115020#ENST00000264380#Other#Cpn60_TCP1, DEP, FYVE, PIP5K$#ENSP00000308715#ENSG00000115020#ENST00000308862#Other#DEP$#ENSP00000376038#ENSG00000115020#ENST00000392202#Other#DEP$#ENSP00000384356#ENSG00000115020#ENST00000407449#Other#DEP, FYVE$#ENSP00000405736#ENSG00000115020#ENST00000452564#Other#Cpn60_TCP1, DEP, FYVE FALSE 2333 ENSG00000137193 PIM1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Affects transcription by phosphorylating TFs (PMID: 18593906) IPR000719;IPR002290;IPR008271;IPR011009;IPR017441 5292 Pim-1 proto-oncogene, serine/threonine kinase [Source:HGNC Symbol;Acc:HGNC:8986] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Sam Lambert Laura Campitelli No $#ENSG00000137193#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:18593906 $#ENSP00000362608#ENSG00000137193#ENST00000373509#Other#Kdo, Kinase-like, Pkinase, Pkinase_Tyr FALSE 2334 ENSG00000158828 PINK1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None None 102464833 Serine/threonine-protein kinase PINK1, mitochondrial None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Yimeng Yin Sam Lambert No $#ENSG00000158828#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019 $##ENSG00000158828##Other# FALSE 2335 ENSG00000170927 PKHD1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None The TIG domain is potentially DNA-binding but there is no literature evidence to suggest that PKHD1 is a TF. Membrane protein that operates upstream in the signaling cascade leading to NFKB (PMID: 21300060) IPR002909;IPR006626;IPR011050;IPR014756;IPR019316; 5314 polycystic kidney and hepatic disease 1 (autosomal recessive) [Source:HGNC Symbol;Acc:HGNC:9016] None not tested not tested None None x No No Yes 4a, two or more datasets predict it as a TF Arttu Jolma Sam Lambert No $#ENSG00000170927#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IMP - PMID:21300060 $#ENSP00000360158#ENSG00000170927#ENST00000371117#Other#Beta_helix, G8, NosD, PA14, TIG$#ENSP00000341097#ENSG00000170927#ENST00000340994#Other#Beta_helix, G8, NosD, PA14, TIG FALSE 2336 ENSG00000205038 PKHD1L1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Membrane receptor (PMID: 12620974) IPR002909;IPR006626;IPR008972;IPR011050;IPR011658;IPR014756;IPR019316; 93035 polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1 [Source:HGNC Symbol;Acc:HGNC:20 None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Pratyush Das Sam Lambert No None $#ENSP00000367655#ENSG00000205038#ENST00000378402#Other#Beta_helix, G8, PA14, TIG$#ENSP00000437376#ENSG00000205038#ENST00000526472#Other#Beta_helix, G8, NosD FALSE 2337 ENSG00000069764 PLA2G10 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR001211;IPR013090;IPR016090 8399 phospholipase A2 group X [Source:HGNC Symbol;Acc:HGNC:9029] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Jussi Taipale Pratyush Das No $#ENSG00000069764#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:20844270 $#ENSP00000393847#ENSG00000069764#ENST00000438167#Other#Phospholip_A2_1 FALSE 2338 ENSG00000170890 PLA2G1B Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR001211;IPR013090;IPR016090 5319 phospholipase A2 group IB [Source:HGNC Symbol;Acc:HGNC:9030] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Sam Lambert Laura Campitelli No $#ENSG00000170890#GO:0051092#positive regulation of NF-kappaB transcription factor activity#ISS - PMID:15528384 $#ENSP00000312286#ENSG00000170890#ENST00000308366#Other#Parvo_coat_N, Phospholip_A2_1$#ENSP00000413594#ENSG00000170890#ENST00000423423#Other#Phospholip_A2_1$#ENSP00000447233#ENSG00000170890#ENST00000549767#Other#Parvo_coat_N, Phospholip_A2_1 FALSE 2339 ENSG00000115956 PLEK Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None The DEP-domain is a winged helix-turn-helix protein domain, and thus it is related to ETS, RFX, and FOX domains. However, there is no evidence for DNA-binding activity and it has been shown to operate in G-protein signalling upstream of TFs IPR000591;IPR001849 5341 pleckstrin [Source:HGNC Symbol;Acc:HGNC:9070] None not tested not tested None None c No No No 5a, one of the source datasets predicts is as a TF Arttu Jolma Laura Campitelli No None $#ENSP00000234313#ENSG00000115956#ENST00000234313#Other#DEP, PH, PH_11, PH_13, PH_6, PH_8, PH_9 FALSE 2340 ENSG00000100558 PLEK2 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000591;IPR001849 26499 pleckstrin 2 [Source:HGNC Symbol;Acc:HGNC:19238] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Jussi Taipale Yimeng Yin No None $#ENSP00000216446#ENSG00000100558#ENST00000216446#Other#DEP, PH, PH_11, PH_3, PH_6, PH_8, PH_9$#ENSP00000450533#ENSG00000100558#ENST00000556532#Other#PH, PH_9$#ENSP00000450892#ENSG00000100558#ENST00000554395#Other#DEP, PH FALSE 2341 ENSG00000105559 PLEKHA4 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif Has a putative AT-hook No DBDs; no indication of DNA binding - included only because Vasquerizas 2009 included it with an x. IPR001849; 57664 pleckstrin homology domain containing A4 [Source:HGNC Symbol;Acc:HGNC:14339] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Tim Hughes Yimeng Yin No None $#ENSP00000263265#ENSG00000105559#ENST00000263265#Other#IncA, PH, PH_11, PH_8$#ENSP00000347683#ENSG00000105559#ENST00000355496#Other#PH, PH_11, PH_8$#ENSP00000472636#ENSG00000105559#ENST00000594195#Other#IncA$#ENSP00000471274#ENSG00000105559#ENST00000594100#Other#PH, PH_11$#ENSP00000469211#ENSG00000105559#ENST00000595867#Other#$#ENSP00000471462#ENSG00000105559#ENST00000597129#Other# FALSE 2342 ENSG00000162407 PLPP3 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000326 8613 phospholipid phosphatase 3 [Source:HGNC Symbol;Acc:HGNC:9229] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Laura Campitelli Pratyush Das No $#ENSG00000162407#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:20123964 $#ENSP00000360296#ENSG00000162407#ENST00000371250#Other#C1-set_C, PAP2, PAP2_3, PAP2_C FALSE 2343 ENSG00000188313 PLSCR1 Unknown Yes Likely to be sequence specific TF Monomer or homomultimer No motif None PLSCR1 has been demonstrated to bind a GTAACCATGTGGA sequence in the IP3R1 promoter (PMID:16091359), mediated by a specific portion of the protein. IPR005552;IPR025659 5359 phospholipid scramblase 1 [Source:HGNC Symbol;Acc:HGNC:9092] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Sam Lambert Pratyush Das No $#ENSG00000188313#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:16091359 $#ENSP00000345494#ENSG00000188313#ENST00000342435#Other#Scramblase$#ENSP00000411675#ENSG00000188313#ENST00000448787#Other#Scramblase FALSE 2344 ENSG00000114554 PLXNA1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Protein is a semaphorin receptor that operates far upstream on the signaling cascade. IPR001627;IPR002165;IPR002909;IPR008936;IPR013548;IPR014756;IPR016201; 5361 plexin A1 [Source:HGNC Symbol;Acc:HGNC:9099] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Jussi Taipale Matt Weirauch No None $#ENSP00000377061#ENSG00000114554#ENST00000393409#Other#PSI, Plexin_cytopl, RasGAP, Sema, TIG FALSE 2345 ENSG00000076356 PLXNA2 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Protein is a semaphorin receptor that operates far upstream on the signaling cascade. IPR001627;IPR002165;IPR002909;IPR008936;IPR013548;IPR014756;IPR016201; 5362 plexin A2 [Source:HGNC Symbol;Acc:HGNC:9100] None Full not tested None None x No No No 5a, one of the source datasets predicts is as a TF Arttu Jolma Laura Campitelli No None $#ENSP00000356000#ENSG00000076356#ENST00000367033#Other#PSI, Plexin_cytopl, RasGAP, Sema, TIG FALSE 2346 ENSG00000130827 PLXNA3 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Protein is a semaphorin receptor that operates far upstream on the signaling cascade. IPR001627;IPR002165;IPR002909;IPR008936;IPR013548;IPR014756;IPR016201; 55558 Plexin A3 [Source:HGNC Symbol;Acc:HGNC:9101] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Laura Campitelli Arttu Jolma No None $#ENSP00000358696#ENSG00000130827#ENST00000369682#Other#PSI, Plexin_cytopl, Sema, TIG FALSE 2347 ENSG00000221866 PLXNA4 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Protein is a semaphorin receptor that operates far upstream on the signaling cascade (PMID: 12591607). IPR001627;IPR002165;IPR002909;IPR008936;IPR013548;IPR014756;IPR016201; 91584 Plexin A4 [Source:HGNC Symbol;Acc:HGNC:9102] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Arttu Jolma Pratyush Das No None $##ENSG00000221866##Other# FALSE 2348 ENSG00000164050 PLXNB1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Protein is a semaphorin receptor that operates far upstream on the signaling cascade. IPR001627;IPR002165;IPR002909;IPR008936;IPR013548;IPR014756;IPR016201; 5364 plexin B1 [Source:HGNC Symbol;Acc:HGNC:9103] None Full not tested None None x No No No 5a, one of the source datasets predicts is as a TF Sam Lambert Arttu Jolma No None $#ENSP00000296440#ENSG00000164050#ENST00000296440#Other#PSI, Plexin_cytopl, Sema, TIG$#ENSP00000351338#ENSG00000164050#ENST00000358536#Other#PSI, Plexin_cytopl, Sema, TIG$#ENSP00000414199#ENSG00000164050#ENST00000456774#Other#PSI, Plexin_cytopl, Sema, TIG FALSE 2349 ENSG00000196576 PLXNB2 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR001627;IPR002165;IPR002909;IPR008936;IPR013548;IPR014756;IPR016201; 23654 plexin B2 [Source:HGNC Symbol;Acc:HGNC:9104] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Yimeng Yin Sam Lambert No None $#ENSP00000400679#ENSG00000196576#ENST00000411680#Other#Plexin_cytopl$#ENSP00000387470#ENSG00000196576#ENST00000425954#Other#Sema$#ENSP00000415757#ENSG00000196576#ENST00000434732#Other#$#ENSP00000406048#ENSG00000196576#ENST00000427829#Other#TIG FALSE 2350 ENSG00000198753 PLXNB3 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Protein is a semaphorin receptor that operates far upstream on the signaling cascade. IPR001627;IPR002165;IPR002909;IPR008936;IPR013548;IPR014756;IPR016201; 5365 plexin B3 [Source:HGNC Symbol;Acc:HGNC:9105] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Sam Lambert Arttu Jolma No None $#ENSP00000355378#ENSG00000198753#ENST00000361971#Other#PSI, Plexin_cytopl, Sema, TIG$#ENSP00000412454#ENSG00000198753#ENST00000448847#Other#Plexin_cytopl$#ENSP00000396048#ENSG00000198753#ENST00000455214#Other#Plexin_cytopl FALSE 2351 ENSG00000136040 PLXNC1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR001627;IPR002165;IPR002909;IPR008936;IPR013548;IPR016201 10154 plexin C1 [Source:HGNC Symbol;Acc:HGNC:9106] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Laura Campitelli Jussi Taipale No None $#ENSP00000258526#ENSG00000136040#ENST00000258526#Other#PSI, Plexin_cytopl, Sema, TIG$#ENSP00000439225#ENSG00000136040#ENST00000545312#Other#Plexin_cytopl$#ENSP00000446720#ENSG00000136040#ENST00000547057#Other#Plexin_cytopl FALSE 2352 ENSG00000004399 PLXND1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Protein is a semaphorin receptor that operates far upstream on the signaling cascade. IPR001627;IPR002165;IPR002909;IPR008936;IPR013548;IPR014756;IPR016201; 23129 plexin D1 [Source:HGNC Symbol;Acc:HGNC:9107] None Full not tested None None x No No No 5a, one of the source datasets predicts is as a TF Arttu Jolma Tim Hughes No None $#ENSP00000317128#ENSG00000004399#ENST00000324093#Other#PSI, Plexin_cytopl, Sema, TIG$#ENSP00000426162#ENSG00000004399#ENST00000504689#Other#Plexin_cytopl$#ENSP00000426241#ENSG00000004399#ENST00000505237#Other#PSI, PSI_integrin, Sema$#ENSP00000427696#ENSG00000004399#ENST00000506979#Other#Plexin_cytopl FALSE 2353 ENSG00000140464 PML Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Likely a transcriptional cofactor. Does not have any clear DBDs. RING-fingers are more typically protein-protein interaction domains IPR000315;IPR001841;IPR017907;IPR021978 5371 promyelocytic leukemia [Source:HGNC Symbol;Acc:HGNC:9113] None not tested not tested None None No No TF Gene Candidate_Transcription Regulatory Activity: heterochromatin interaction/binding_Other_PMIDS:11259576;14663483;17173041 No 5a, one of the source datasets predicts is as a TF Arttu Jolma Jussi Taipale No None $##ENSG00000140464##Other# FALSE 2354 ENSG00000039650 PNKP Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None Binds DNA in the crystal structure (PDB: 3ZVN) None None polynucleotide kinase 3'-phosphatase 3ZVN not tested not tested None Binds DNA in the crystal structure (PDB: 3ZVN) No No No No New proteins added based on PDB entry Arttu Jolma Sam Lambert No None None FALSE 2355 ENSG00000143442 POGZ Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None Has a potential DBD that is similar to Drosophila Brinker but no other data suggesting TF function. Likely co-factor. IPR004875;IPR006600;IPR007087;IPR009057;IPR015880; 23126 pogo transposable element with ZNF domain [Source:HGNC Symbol;Acc:HGNC:18801] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Sam Lambert Arttu Jolma Yes None $#ENSP00000271715#ENSG00000143442#ENST00000271715#Other#DDE_1, HTH_28, HTH_Tnp_Tc5, zf-C2H2_4, zf-RRN7$#ENSP00000357856#ENSG00000143442#ENST00000368863#Other#DDE_1, HTH_28, HTH_Tnp_Tc5, zf-C2H2_4, zf-RRN7$#ENSP00000376484#ENSG00000143442#ENST00000392723#Other#DDE_1, HTH_28, HTH_Tnp_Tc5, zf-C2H2_4, zf-RRN7$#ENSP00000386836#ENSG00000143442#ENST00000409503#Other#DDE_1, HTH_28, HTH_Tnp_Tc5, zf-C2H2_4, zf-RRN7$#ENSP00000431259#ENSG00000143442#ENST00000531094#Other#DDE_1, HTH_28, HTH_Tnp_Tc5, zf-C2H2_4, zf-RRN7$#ENSP00000390156#ENSG00000143442#ENST00000439756#Other#$#ENSP00000395332#ENSG00000143442#ENST00000450842#Other#$#ENSP00000472860#ENSG00000143442#ENST00000594456#Other# FALSE 2356 ENSG00000101868 POLA1 Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None Binds DNA in the crystal structure (PDB: 4Q5V) None None polymerase (DNA) alpha 1, catalytic subunit 4Q5V not tested not tested None Binds DNA in the crystal structure (PDB: 4Q5V) No No No No New proteins added based on PDB entry Arttu Jolma Sam Lambert No None None FALSE 2357 ENSG00000070501 POLB Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None DNA polymerase that participates in base excision repair. Binds DNA in the crystal structure (PDB: 1BPX) None None polymerase (DNA) beta 1BPX not tested not tested None DNA polymerase that participates in base excision repair. Binds DNA in the crystal structure (PDB: 1BPX) No No No No New proteins added based on PDB entry Arttu Jolma Sam Lambert No None None FALSE 2358 ENSG00000148229 POLE3 Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None None IPR003958;IPR009072 54107 polymerase (DNA) epsilon 3, accessory subunit [Source:HGNC Symbol;Acc:HGNC:13546] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Matt Weirauch Laura Campitelli No None $#ENSP00000363284#ENSG00000148229#ENST00000374169#Other#BUD22, CBFD_NFYB_HMF, CENP-T_C, DUF1510, Histone$#ENSP00000363286#ENSG00000148229#ENST00000374171#Other#BUD22, CBFD_NFYB_HMF, CENP-T_C, DUF1510, Histone FALSE 2359 ENSG00000115350 POLE4 Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None Histone-like subunit of DNA polymerase epsilon IPR003958;IPR009072 56655 polymerase (DNA) epsilon 4, accessory subunit [Source:HGNC Symbol;Acc:HGNC:18755] None Full not tested None None x No No No 5a, one of the source datasets predicts is as a TF Arttu Jolma Tim Hughes No None $#ENSP00000420176#ENSG00000115350#ENST00000483063#Other#CBFD_NFYB_HMF, Histone, TAF FALSE 2360 ENSG00000140521 POLG Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None Binds DNA in the crystal structure (PDB: 4ZTU) None None polymerase (DNA) gamma, catalytic subunit 4ZTU not tested not tested None Binds DNA in the crystal structure (PDB: 4ZTU) No No No No New proteins added based on PDB entry Arttu Jolma Sam Lambert No None None FALSE 2361 ENSG00000170734 POLH Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None DNA polymerase. Binds DNA in the crystal structure (PDB: 3JAA) None None polymerase (DNA) eta 3JAA not tested not tested None DNA polymerase. Binds DNA in the crystal structure (PDB: 3JAA) No No No No New proteins added based on PDB entry Arttu Jolma Sam Lambert No None None FALSE 2362 ENSG00000101751 POLI Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None DNA polymerase. Binds DNA in the crystal structure (PDB: 1T3N) None None polymerase (DNA) iota 1T3N not tested not tested None DNA polymerase. Binds DNA in the crystal structure (PDB: 1T3N) No No No No New proteins added based on PDB entry Arttu Jolma Sam Lambert No None None FALSE 2363 ENSG00000122008 POLK Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None DNA polymerase. Binds DNA in the crystal structure (PDB: 2OH2) None None polymerase (DNA) kappa 2OH2 not tested not tested None DNA polymerase. Binds DNA in the crystal structure (PDB: 2OH2) No No No No New proteins added based on PDB entry Arttu Jolma Sam Lambert No None None FALSE 2364 ENSG00000166169 POLL Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None DNA polymerase. Binds DNA in the crystal structure (PDB: 1RZT) None None polymerase (DNA) lambda 1RZT not tested not tested None DNA polymerase. Binds DNA in the crystal structure (PDB: 1RZT) No No No No New proteins added based on PDB entry Arttu Jolma Sam Lambert No None None FALSE 2365 ENSG00000122678 POLM Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None DNA polymerase that operates on non-homologous end joining. Binds DNA in the crystal structure (PDB: 2IHM) None None polymerase (DNA) mu 2IHM not tested not tested None DNA polymerase that operates on non-homologous end joining. Binds DNA in the crystal structure (PDB: 2IHM) No No No No New proteins added based on PDB entry Arttu Jolma Sam Lambert No None None FALSE 2366 ENSG00000130997 POLN Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None Binds DNA in the crystal structure (PDB: 4XVI) None None polymerase (DNA) nu 4XVI not tested not tested None Binds DNA in the crystal structure (PDB: 4XVI) No No No No New proteins added based on PDB entry Arttu Jolma Sam Lambert No None None FALSE 2367 ENSG00000051341 POLQ Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None Binds DNA in the crystal structure (PDB: 4X0P) None None polymerase (DNA) theta 4X0P not tested not tested None Binds DNA in the crystal structure (PDB: 4X0P) No No No No New proteins added based on PDB entry Arttu Jolma Sam Lambert No None None FALSE 2368 ENSG00000125630 POLR1B Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None General Transcription Factor IPR007120;IPR007121;IPR007641;IPR007642;IPR007644;IPR007645;IPR007647;IPR009674 84172 polymerase (RNA) I subunit B [Source:HGNC Symbol;Acc:HGNC:20454] None not tested not tested None None No No TF Gene_Basal Transcription Factor__PMIDS:0 No 5a, one of the source datasets predicts is as a TF Sam Lambert Pratyush Das No None $##ENSG00000125630##Other# FALSE 2369 ENSG00000181222 POLR2A Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None Contacts DNA in the structure (PDB: 5FLM) IPR000684;IPR000722;IPR006592;IPR007066;IPR007073;IPR007075;IPR007080;IPR007081;IPR007083 5430 polymerase (RNA) II (DNA directed) polypeptide A 5FLM not tested not tested None In the structure the protein contacts DNA, but it is likely sequence nonspecific No No TF Gene_Basal Transcription Factor_DNA Binding; TF PPI_PMIDS:8870495 No 5a, one of the source datasets predicts is as a TF Sam Lambert Pratyush Das No None $##ENSG00000181222##Other# FALSE 2370 ENSG00000047315 POLR2B Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None Contacts DNA in the structure (PDB: 5FLM) IPR007120;IPR007121;IPR007641;IPR007642;IPR007644;IPR007645;IPR007646;IPR007647 5431 polymerase (RNA) II subunit B [Source:HGNC Symbol;Acc:HGNC:9188] 5FLM not tested not tested None In the structure the protein contacts DNA but it is likely nonspecific No No TF Gene_DNA-Binding: non-sequence-specific; Basal Transcription Factor; Transcription Factor Binding: tf co-factor binding_DNA Binding; Non-specific DNA; TF PPI_PMIDS:10784442 No 5a, one of the source datasets predicts is as a TF Pratyush Das Tim Hughes No None $##ENSG00000047315##Other# FALSE 2371 ENSG00000099817 POLR2E Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None RNA-polymerase subunit. Binds DNA in the crystal structure (PDB: 5IY6) None None polymerase (RNA) II subunit E 5IY6 not tested not tested None RNA-polymerase subunit. Binds DNA in the crystal structure (PDB: 5IY6) No No No No New proteins added based on PDB entry Arttu Jolma Sam Lambert No None None FALSE 2372 ENSG00000005075 POLR2J Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Does not contact DNA in the structure (PDB: 5FLM) IPR008193;IPR009025 5439 polymerase (RNA) II subunit J [Source:HGNC Symbol;Acc:HGNC:9197] 5FLM not tested not tested None In the structure the protein does not contact the DNA No No TF Gene_Basal Transcription Factor__PMIDS:0 No 5a, one of the source datasets predicts is as a TF Tim Hughes Arttu Jolma No None $##ENSG00000005075##Other# FALSE 2373 ENSG00000147669 POLR2K Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Does not contact DNA in the structure (PDB: 5FLM) IPR006591;IPR029040 5440 polymerase (RNA) II subunit K [Source:HGNC Symbol;Acc:HGNC:9198] 5FLM not tested not tested None In the structure the protein does not contact DNA No No TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_DNA Binding; Transactivation_PMIDS:7651387 No 5a, one of the source datasets predicts is as a TF Pratyush Das Jussi Taipale No None $##ENSG00000147669##Other# FALSE 2374 ENSG00000177700 POLR2L Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Does not contact DNA in the structure (PDB: 5FLM) IPR000268;IPR020789;IPR023580; 5441 polymerase (RNA) II subunit L [Source:HGNC Symbol;Acc:HGNC:9199] 5FLM not tested not tested None In the structure the protein does not contact the DNA x No No No 5a, one of the source datasets predicts is as a TF Sam Lambert Pratyush Das No None $#ENSP00000324124#ENSG00000177700#ENST00000322028#Other#RNA_pol_N FALSE 2375 ENSG00000148606 POLR3A Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None Transfac motifs are dubious, and do not appear to be similar to any known motifs. IPR000722;IPR006592;IPR007066;IPR007080;IPR007081;IPR007083 11128 polymerase (RNA) III subunit A [Source:HGNC Symbol;Acc:HGNC:30074] None not tested not tested None None No Yes No No 2a1, Lower confidence direct evidence Sam Lambert Pratyush Das No None $#ENSP00000361446#ENSG00000148606#ENST00000372371#Other#RNA_pol_Rpb1_1, RNA_pol_Rpb1_2, RNA_pol_Rpb1_3, RN$#ENSP00000483738#ENSG00000148606#ENST00000616246#Other#RNA_pol_Rpb1_5 FALSE 2376 ENSG00000099821 POLRMT Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None Binds DNA in the crystal structure (PDB: 4BOC) None None polymerase (RNA) mitochondrial 4BOC not tested not tested None Binds DNA in the crystal structure (PDB: 4BOC) No No No No New proteins added based on PDB entry Arttu Jolma Sam Lambert No None None FALSE 2377 ENSG00000128513 POT1 Unknown No ssDNA/RNA binding Not a DNA binding protein No motif None Binds single stranded DNA in the structure (PDB: 1XJV) None None protection of telomeres 1 1XJV not tested not tested None Binds single stranded DNA in the structure (PDB: 1XJV) No No No No New proteins added based on PDB entry Arttu Jolma Sam Lambert No None None FALSE 2378 ENSG00000110777 POU2AF1 Unknown Yes Known motif Obligate heteromer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain Requires POU2F1 to bind DNA. In the crystal structure (PDB:1CQT), POU2AF1 contacts both the POU2F1 and DNA major groove IPR015389 5450 POU class 2 associating factor 1 [Source:HGNC Symbol;Acc:HGNC:9211] 1CQT not tested not tested Needs POU2F1 to bind DNA, in the crystal structure None No Yes TF Gene_Transcription Factor Binding: tf co-factor binding_Co-activation; TF PPI_PMIDS:7623806;7779176 No 1a1, Direct HQ evidence Laura Campitelli Arttu Jolma No None $#ENSP00000376786#ENSG00000110777#ENST00000393067#Other#PD-C2-AF1$#ENSP00000433527#ENSG00000110777#ENST00000531398#Other#PD-C2-AF1 FALSE 2379 ENSG00000109819 PPARGC1A Unknown No ssDNA/RNA binding Not a DNA binding protein No motif None None IPR000504 10891 PPARG coactivator 1 alpha [Source:HGNC Symbol;Acc:HGNC:9237] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Yimeng Yin Matt Weirauch No $#ENSG00000109819#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:19651776 $#ENSP00000264867#ENSG00000109819#ENST00000264867#Other#$#ENSP00000481498#ENSG00000109819#ENST00000613098#Other#$#ENSP00000424181#ENSG00000109819#ENST00000507380#Other# FALSE 2380 ENSG00000155846 PPARGC1B Unknown No ssDNA/RNA binding Not a DNA binding protein No motif None Contains a single RRM domain, so could possibly be an RNA binding protein IPR000504 133522 PPARG coactivator 1 beta [Source:HGNC Symbol;Acc:HGNC:30022] None not tested not tested None None No No TF Gene_Transcription Factor Binding: tf co-factor binding_Co-activation_PMIDS:11854298 Yes 4a, two or more datasets predict it as a TF Pratyush Das Arttu Jolma No $#ENSG00000155846#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000312649#ENSG00000155846#ENST00000309241#Other#DUF2052$#ENSP00000353638#ENSG00000155846#ENST00000360453#Other#DUF2052$#ENSP00000377855#ENSG00000155846#ENST00000394320#Other#DUF2052$#ENSP00000409364#ENSG00000155846#ENST00000434684#Other#DUF2052$#ENSP00000384403#ENSG00000155846#ENST00000403750#Other#DUF2052 FALSE 2381 ENSG00000104881 PPP1R13L Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR001452;IPR002110;IPR020683; 10848 protein phosphatase 1 regulatory subunit 13 like [Source:HGNC Symbol;Acc:HGNC:18838] None Full not tested None None x No No No 5a, one of the source datasets predicts is as a TF Laura Campitelli Sam Lambert Yes None $#ENSP00000354218#ENSG00000104881#ENST00000360957#Other#Ank, Ank_2, Ank_3, Ank_4, Ank_5, SH3_1, SH3_2, SH3$#ENSP00000403902#ENSG00000104881#ENST00000418234#Other#Ank, Ank_2, Ank_3, Ank_4, Ank_5, SH3_1, SH3_2, SH3$#ENSP00000466555#ENSG00000104881#ENST00000589371#Other#SH3_2, SH3_9$#ENSP00000466939#ENSG00000104881#ENST00000591986#Other#$#ENSP00000467471#ENSG00000104881#ENST00000592134#Other#$#ENSP00000466730#ENSG00000104881#ENST00000593226#Other# FALSE 2382 ENSG00000167393 PPP2R3B Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR002048;IPR011992;IPR018247; 28227 protein phosphatase 2 regulatory subunit Bbeta [Source:HGNC Symbol;Acc:HGNC:13417] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Pratyush Das Sam Lambert No None $#ENSP00000375080#ENSG00000167393#ENST00000390665#Other#EF-hand_1, EF-hand_5, EF-hand_6, EF-hand_7, EF-han$#ENSP00000371038#ENSG00000167393#ENST00000381625#Other# FALSE 2383 ENSG00000068971 PPP2R5B Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None None 5526 Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Laura Campitelli Tim Hughes No $#ENSG00000068971#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019 $##ENSG00000068971##Other# FALSE 2384 ENSG00000138814 PPP3CA Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None None 5530 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Matt Weirauch Sam Lambert No $#ENSG00000138814#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019 $##ENSG00000138814##Other# FALSE 2385 ENSG00000148840 PPRC1 Unknown No ssDNA/RNA binding Not a DNA binding protein No motif None None IPR000504 23082 peroxisome proliferator-activated receptor gamma, coactivator-related 1 [Source:HGNC Symbol;Acc:HGNC None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Pratyush Das Yimeng Yin No $#ENSG00000148840#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000278070#ENSG00000148840#ENST00000278070#Other#$#ENSP00000359029#ENSG00000148840#ENST00000370012#Other#$#ENSP00000399743#ENSG00000148840#ENST00000413464#Other#RSRP, SR-25 FALSE 2386 ENSG00000102103 PQBP1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Has a WW domain. May interact with Pol II, but no indication of sequence specific DNA binding IPR001202 10084 polyglutamine binding protein 1 [Source:HGNC Symbol;Acc:HGNC:9330] None not tested not tested None None No No TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:10332029 No 5a, one of the source datasets predicts is as a TF Yimeng Yin Tim Hughes No None $##ENSG00000102103##Other# FALSE 2387 ENSG00000133246 PRAM1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR001452;IPR029294 84106 PML-RARA regulated adaptor molecule 1 [Source:HGNC Symbol;Acc:HGNC:30091] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Matt Weirauch Yimeng Yin No None $#ENSP00000408342#ENSG00000133246#ENST00000423345#Other#SH3_2, hSH3$#ENSP00000471634#ENSG00000133246#ENST00000600262#Other# FALSE 2388 ENSG00000165828 PRAP1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR007087;IPR015880;IPR027922 118471 proline rich acidic protein 1 [Source:HGNC Symbol;Acc:HGNC:23304] None not tested not tested None None No Yes No No 5a, one of the source datasets predicts is as a TF Laura Campitelli Jussi Taipale No None $#ENSP00000416126#ENSG00000165828#ENST00000433452#Other#PRAP$#ENSP00000486265#ENSG00000165828#ENST00000463201#Other#PRAP FALSE 2389 ENSG00000197870 PRB3 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Human salivary glycoprotein IPR026086; 5544 proline rich protein BstNI subfamily 3 None Full not tested None None x No No No 5a, one of the source datasets predicts is as a TF Arttu Jolma Pratyush Das No None $#ENSP00000371264#ENSG00000197870#ENST00000381842#Other#Pro-rich$#ENSP00000442626#ENSG00000197870#ENST00000538488#Other#Pro-rich FALSE 2390 ENSG00000126856 PRDM7 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Only has KRAB and SET domains - no C2H2 ZFs. IPR001214;IPR001909;IPR003655;IPR019041 11105 PR domain 7 [Source:HGNC Symbol;Acc:HGNC:9351] None Full not tested None None a No No No 5a, one of the source datasets predicts is as a TF Arttu Jolma Tim Hughes No None $#ENSP00000396732#ENSG00000126856#ENST00000449207#Other#KRAB, SET, SSXRD FALSE 2391 ENSG00000165672 PRDX3 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000866;IPR012336;IPR019479 10935 peroxiredoxin 3 [Source:HGNC Symbol;Acc:HGNC:9354];Thioredoxin-dependent peroxide reductase, mitocho None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Matt Weirauch Jussi Taipale No $#ENSG00000165672#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IDA - PMID:12492477 $#ENSP00000298510#ENSG00000165672#ENST00000298510#Other#1-cysPrx_C, AhpC-TSA, Redoxin FALSE 2392 ENSG00000138073 PREB Unknown Yes Likely to be sequence specific TF Monomer or homomultimer No motif None In vitro gel-shift experiments show that PREB binds specific promoter sequences (PMID: 10194769; PMID: 19426980) without the presence of a canonical DBD IPR001680;IPR011047;IPR017986; 10113 prolactin regulatory element binding [Source:HGNC Symbol;Acc:HGNC:9356] None Full not tested None None other No TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:10194769 No 4a, two or more datasets predict it as a TF Laura Campitelli Sam Lambert No None $#ENSP00000260643#ENSG00000138073#ENST00000260643#Other#ANAPC4_WD40, WD40$#ENSP00000407036#ENSG00000138073#ENST00000430533#Other#$#ENSP00000397036#ENSG00000138073#ENST00000456259#Other#$#ENSP00000384032#ENSG00000138073#ENST00000406567#Other#ANAPC4_WD40, WD40 FALSE 2393 ENSG00000124126 PREX1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Included only because Vasquerizas 2009 includes it with an x. No DBD and no other data to support being a TF. IPR000219;IPR000591;IPR001331;IPR001478;IPR001849; 57580 phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1 [Source:HGNC Symbol;Acc:HGN None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Tim Hughes Laura Campitelli No None $#ENSP00000361009#ENSG00000124126#ENST00000371941#Other#DEP, PDZ, PDZ_2, PH, PH_10, RhoGEF$#ENSP00000481444#ENSG00000124126#ENST00000620554#Other# FALSE 2394 ENSG00000046889 PREX2 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000219;IPR000591;IPR001331;IPR001478;IPR001849; 80243 phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2 [Source:HGNC Symbol;Acc:HGN None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Jussi Taipale Tim Hughes No None $#ENSP00000288368#ENSG00000046889#ENST00000288368#Other#DEP, PDZ, PDZ_2, PH, RhoGEF FALSE 2395 ENSG00000134551 PRH2 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR026086; 5555 proline rich protein HaeIII subfamily 2 None Full not tested None None x No No No 5a, one of the source datasets predicts is as a TF Jussi Taipale Sam Lambert No None $#ENSP00000371271#ENSG00000134551#ENST00000381847#Other#Pro-rich$#ENSP00000379682#ENSG00000134551#ENST00000396400#Other#Pro-rich FALSE 2396 ENSG00000146143 PRIM2 Unknown No ssDNA/RNA binding Not a DNA binding protein No motif None Binds DNA-RNA hybrid in the structure (PDB: 5F0Q) None None primase (DNA) subunit 2 5F0Q not tested not tested None Binds DNA-RNA hybrid in the structure (PDB: 5F0Q) No No No No New proteins added based on PDB entry Arttu Jolma Sam Lambert No None None FALSE 2397 ENSG00000164306 PRIMPOL Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None Involved in DNA replication. Binds DNA in the crystal structure (PDB: 5L2X), presumably non-specifically. None None primase and DNA directed polymerase 5L2X not tested not tested None Involved in DNA replication. Binds DNA in the crystal structure (PDB: 5L2X), presumably non-specifically. No No No No New proteins added based on PDB entry Arttu Jolma Sam Lambert No None None FALSE 2398 ENSG00000166501 PRKCB Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000008;IPR000719;IPR000961;IPR002219;IPR002290;IPR008271;IPR011009;IPR014375;IPR017441;IPR017892;IPR020454 5579 protein kinase C beta [Source:HGNC Symbol;Acc:HGNC:9395] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Yimeng Yin Jussi Taipale No $#ENSG00000166501#GO:0051092#positive regulation of NF-kappaB transcription factor activity#ISS - GO_REF:0000024 $#ENSP00000305355#ENSG00000166501#ENST00000303531#Other#C1_1, C1_2, C2, Kinase-like, Pkinase, Pkinase_C, P$#ENSP00000318315#ENSG00000166501#ENST00000321728#Other#C1_1, C1_2, C2, CEP76-C2, Kinase-like, Pkinase, Pk$#ENSP00000458564#ENSG00000166501#ENST00000466124#Other#$#ENSP00000457980#ENSG00000166501#ENST00000472066#Other#Pkinase, Pkinase_Tyr$#ENSP00000454428#ENSG00000166501#ENST00000498058#Other#C1_1 FALSE 2399 ENSG00000027075 PRKCH Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Protein is a kinase that activates another kinase leading to degradation of NFKB inhibitor NFKBIA (PMID: 21820409) IPR000008;IPR000719;IPR000961;IPR002219;IPR002290;IPR008271;IPR011009;IPR014376;IPR017441;IPR017892;IPR020454; 5583 protein kinase C eta [Source:HGNC Symbol;Acc:HGNC:9403] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Arttu Jolma Jussi Taipale No $#ENSG00000027075#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IMP - PMID:21820409 $#ENSP00000329127#ENSG00000027075#ENST00000332981#Other#C1_1, C1_2, C2, FTA2, Kinase-like, Pkinase, Pkinas$#ENSP00000450981#ENSG00000027075#ENST00000555082#Other#C1_1, C1_2, FTA2, Kinase-like, Pkinase, Pkinase_C,$#ENSP00000451871#ENSG00000027075#ENST00000555185#Other#APH, Kinase-like, Pkinase, Pkinase_Tyr$#ENSP00000451205#ENSG00000027075#ENST00000555906#Other#C1_1$#ENSP00000452330#ENSG00000027075#ENST00000556164#Other#C1_1$#ENSP00000452528#ENSG00000027075#ENST00000557473#Other#C1_1 FALSE 2400 ENSG00000163558 PRKCI Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Kinase that operates upstream in the signaling cascade that leads to NFKB IPR000270;IPR000719;IPR000961;IPR002219;IPR002290;IPR008271;IPR011009;IPR012233;IPR017441;IPR017892;IPR020454 5584 protein kinase C iota [Source:HGNC Symbol;Acc:HGNC:9404] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Matt Weirauch Arttu Jolma No $#ENSG00000163558#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IDA - PMID:10467349 $#ENSP00000295797#ENSG00000163558#ENST00000295797#Other#C1_1, Kinase-like, PB1, Pkinase, Pkinase_C, Pkinas FALSE 2401 ENSG00000065675 PRKCQ Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000008;IPR000719;IPR000961;IPR002219;IPR002290;IPR008271;IPR011009;IPR014376;IPR017441;IPR017892;IPR020454; 5588 protein kinase C theta [Source:HGNC Symbol;Acc:HGNC:9410] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Pratyush Das Matt Weirauch No $#ENSG00000065675#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IDA - PMID:16356855 $#ENSP00000263125#ENSG00000065675#ENST00000263125#Other#C1_1, C1_2, Kinase-like, Pkinase, Pkinase_C, Pkina$#ENSP00000441752#ENSG00000065675#ENST00000539722#Other#C1_1, C1_2, Kinase-like, Pkinase, Pkinase_C, Pkina$#ENSP00000380361#ENSG00000065675#ENST00000397176#Other#C1_1, C1_2, Kinase-like, Pkinase, Pkinase_C, Pkina$#ENSP00000483428#ENSG00000065675#ENST00000610727#Other#C1_1, C1_2, Kinase-like, Pkinase, Pkinase_C, Pkina FALSE 2402 ENSG00000067606 PRKCZ Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000270;IPR000719;IPR000961;IPR002219;IPR002290;IPR008271;IPR011009;IPR012233;IPR017441;IPR017892;IPR020454 5590 protein kinase C zeta [Source:HGNC Symbol;Acc:HGNC:9412] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Pratyush Das Laura Campitelli No $#ENSG00000067606#GO:0051092#positive regulation of NF-kappaB transcription factor activity#ISS - GO_REF:0000024 $#ENSP00000367830#ENSG00000067606#ENST00000378567#Other#C1_1, C1_2, Kinase-like, PB1, Pkinase, Pkinase_C, $#ENSP00000383712#ENSG00000067606#ENST00000400921#Other#Kinase-like, Pkinase, Pkinase_C, Pkinase_Tyr$#ENSP00000426412#ENSG00000067606#ENST00000461106#Other#C1_1, Kinase-like, Pkinase, Pkinase_C, Pkinase_Tyr$#ENSP00000424228#ENSG00000067606#ENST00000470596#Other#Pkinase$#ENSP00000421219#ENSG00000067606#ENST00000470986#Other#Pkinase$#ENSP00000427134#ENSG00000067606#ENST00000466352#Other#$#ENSP00000422349#ENSG00000067606#ENST00000471018#Other#$#ENSP00000425317#ENSG00000067606#ENST00000482686#Other#$#ENSP00000424763#ENSG00000067606#ENST00000486681#Other#Pkinase$#ENSP00000422764#ENSG00000067606#ENST00000497183#Other#Pkinase FALSE 2403 ENSG00000184304 PRKD1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000719;IPR001849;IPR002219;IPR002290;IPR008271;IPR011009;IPR015727;IPR017441;IPR020454 5587 protein kinase D1 [Source:HGNC Symbol;Acc:HGNC:9407] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Yimeng Yin Laura Campitelli No $#ENSG00000184304#GO:0032793#positive regulation of CREB transcription factor activity#IGI - PMID:20497126$#ENSG00000184304#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IMP - PMID:12505989 $#ENSP00000333568#ENSG00000184304#ENST00000331968#Other#C1_1, C1_2, Kdo, Kinase-like, PH, Pkinase, Pkinase$#ENSP00000447333#ENSG00000184304#ENST00000546371#Other#PH$#ENSP00000446866#ENSG00000184304#ENST00000549503#Other#C1_1, C1_2 FALSE 2404 ENSG00000105287 PRKD2 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000719;IPR001849;IPR002219;IPR002290;IPR008271;IPR011009;IPR015727;IPR017441;IPR020454 25865 protein kinase D2 [Source:HGNC Symbol;Acc:HGNC:17293] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Matt Weirauch Yimeng Yin No $#ENSG00000105287#GO:0032793#positive regulation of CREB transcription factor activity#IGI - PMID:20497126$#ENSG00000105287#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IMP - PMID:19192391$#ENSG00000105287#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IMP - PMID:15604256, PMID:16928771 $#ENSP00000291281#ENSG00000105287#ENST00000291281#Other#C1_1, C1_2, Kdo, Kinase-like, Pkinase, Pkinase_Tyr$#ENSP00000472987#ENSG00000105287#ENST00000593363#Other#$#ENSP00000470804#ENSG00000105287#ENST00000595515#Other#C1_1, C1_2, Kdo, Kinase-like, Pkinase, Pkinase_Tyr$#ENSP00000472744#ENSG00000105287#ENST00000600194#Other#C1_1, C1_2, Kdo, Kinase-like, Pkinase, Pkinase_Tyr FALSE 2405 ENSG00000185345 PRKN Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Protein is a ubiquitin ligase IPR000626;IPR002867;IPR003977;IPR029071 5071 parkin RBR E3 ubiquitin protein ligase [Source:HGNC Symbol;Acc:HGNC:8607] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Laura Campitelli Arttu Jolma No $#ENSG00000185345#GO:0003700#sequence-specific DNA binding transcription factor activity#IC - PMID:23985028 $#ENSP00000343589#ENSG00000185345#ENST00000338468#Other#IBR$#ENSP00000355862#ENSG00000185345#ENST00000366896#Other#IBR, Rad60-SLD, ubiquitin$#ENSP00000355863#ENSG00000185345#ENST00000366897#Other#IBR, Rad60-SLD, Rad60-SLD_2, ubiquitin$#ENSP00000355865#ENSG00000185345#ENST00000366898#Other#IBR, Rad60-SLD, Rad60-SLD_2, ubiquitin$#ENSP00000483773#ENSG00000185345#ENST00000610470#Other#IBR FALSE 2406 ENSG00000160310 PRMT2 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR001452;IPR007848;IPR025799;IPR029063 3275 protein arginine methyltransferase 2 [Source:HGNC Symbol;Acc:HGNC:5186] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Sam Lambert Jussi Taipale No $#ENSG00000160310#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IDA - PMID:16648481 $#ENSP00000291705#ENSG00000160310#ENST00000291705#Other#MTS, Met_10, Methyltransf_11, Methyltransf_18, Met$#ENSP00000335490#ENSG00000160310#ENST00000334494#Other#MTS, Met_10, Methyltransf_11, Methyltransf_18, Met$#ENSP00000347906#ENSG00000160310#ENST00000355680#Other#MTS, Met_10, Methyltransf_11, Methyltransf_18, Met$#ENSP00000380760#ENSG00000160310#ENST00000397638#Other#MTS, Met_10, Methyltransf_11, Methyltransf_18, Met$#ENSP00000397266#ENSG00000160310#ENST00000440086#Other#MTS, Met_10, Methyltransf_11, Methyltransf_18, Met$#ENSP00000411984#ENSG00000160310#ENST00000451211#Other#MTS, Met_10, Methyltransf_11, Methyltransf_18, Met$#ENSP00000407463#ENSG00000160310#ENST00000458387#Other#MTS, Met_10, Methyltransf_11, Methyltransf_18, Met$#ENSP00000380752#ENSG00000160310#ENST00000397628#Other#MTS, Met_10, Methyltransf_11, Methyltransf_18, Met$#ENSP00000380759#ENSG00000160310#ENST00000397637#Other#MTS, Met_10, Methyltransf_11, Methyltransf_18, Met$#ENSP00000406127#ENSG00000160310#ENST00000455177#Other#MTS, Met_10, Methyltransf_11, Methyltransf_18, Met FALSE 2407 ENSG00000171867 PRNP Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000817;IPR022416;IPR025860 5621 prion protein [Source:HGNC Symbol;Acc:HGNC:9449] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Sam Lambert Yimeng Yin No $#ENSG00000171867#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024 $#ENSP00000368752#ENSG00000171867#ENST00000379440#Other#Prion, Prion_bPrPp$#ENSP00000411599#ENSG00000171867#ENST00000424424#Other#Prion, Prion_bPrPp$#ENSP00000399376#ENSG00000171867#ENST00000430350#Other#Prion, Prion_bPrPp$#ENSP00000415284#ENSG00000171867#ENST00000457586#Other#Prion, Prion_bPrPp FALSE 2408 ENSG00000100902 PSMA6 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000426;IPR001353;IPR023332;IPR029055 5687 proteasome subunit alpha 6 [Source:HGNC Symbol;Acc:HGNC:9535] None not tested Yes None None No No No Yes 5a, one of the source datasets predicts is as a TF Sam Lambert Pratyush Das No $#ENSG00000100902#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IMP - PMID:16845397 $#ENSP00000261479#ENSG00000100902#ENST00000261479#Other#Proteasome, Proteasome_A_N$#ENSP00000444844#ENSG00000100902#ENST00000540871#Other#Proteasome$#ENSP00000452566#ENSG00000100902#ENST00000555764#Other#Proteasome$#ENSP00000479620#ENSG00000100902#ENST00000622405#Other#Proteasome$#ENSP00000452603#ENSG00000100902#ENST00000553809#Other#Proteasome, Proteasome_A_N$#ENSP00000451171#ENSG00000100902#ENST00000556221#Other#Proteasome FALSE 2409 ENSG00000087191 PSMC5 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR003593;IPR003959;IPR003960;IPR005937;IPR027417 5705 proteasome 26S subunit, ATPase 5 [Source:HGNC Symbol;Acc:HGNC:9552] None not tested not tested None None No No TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_Co-activation_PMIDS:7776974;9173976 No 5a, one of the source datasets predicts is as a TF Yimeng Yin Matt Weirauch No None $##ENSG00000087191##Other# FALSE 2410 ENSG00000101843 PSMD10 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None GO annotation has no evidence of DNA-binding activity; only modulation of NF-kappaB activity (PMID: 18040287) IPR002110;IPR020683 5716 proteasome 26S subunit, non-ATPase 10 [Source:HGNC Symbol;Acc:HGNC:9555] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Sam Lambert Laura Campitelli No $#ENSG00000101843#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IDA - PMID:18040287 $#ENSP00000217958#ENSG00000101843#ENST00000217958#Other#Ank, Ank_2, Ank_3, Ank_4, Ank_5$#ENSP00000354906#ENSG00000101843#ENST00000361815#Other#Ank, Ank_2, Ank_3, Ank_4, Ank_5$#ENSP00000345963#ENSG00000101843#ENST00000340200#Other#Ank, Ank_2, Ank_3, Ank_4, Ank_5 FALSE 2411 ENSG00000108671 PSMD11 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000717;IPR013143 5717 proteasome 26S subunit, non-ATPase 11 [Source:HGNC Symbol;Acc:HGNC:9556] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Laura Campitelli Yimeng Yin No None $#ENSP00000261712#ENSG00000108671#ENST00000261712#Other#DDRGK, PCI, TPR_12$#ENSP00000393185#ENSG00000108671#ENST00000457654#Other#DDRGK, PCI, TPR_12$#ENSP00000464434#ENSG00000108671#ENST00000579451#Other#$#ENSP00000462683#ENSG00000108671#ENST00000578213#Other# FALSE 2412 ENSG00000197170 PSMD12 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000717; 5718 proteasome 26S subunit, non-ATPase 12 [Source:HGNC Symbol;Acc:HGNC:9557] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Sam Lambert Pratyush Das No None $#ENSP00000348442#ENSG00000197170#ENST00000356126#Other#PCI$#ENSP00000349667#ENSG00000197170#ENST00000357146#Other#PCI FALSE 2413 ENSG00000121390 PSPC1 Unknown No ssDNA/RNA binding Low specificity DNA-binding protein No motif None Contains RRMs and no DBDs. Mouse orhtolog has been found in androgen receptor complexes (PMID: 16641145) but no DNA-binding activity has been shown. None Has no Entrez identifier Paraspeckle component 1 None not tested not tested None Contains RRMs and no DBDs. Mouse orhtolog has been found in androgen receptor complexes (PMID: 16641145) but no DNA-binding activity has been shown. No No No No New proteins added after initial stage Arttu Jolma Sam Lambert Yes None None FALSE 2414 ENSG00000185920 PTCH1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000731;IPR003392;IPR004766 5727 patched 1 [Source:HGNC Symbol;Acc:HGNC:9585] None not tested not tested None None No No TF Gene Candidate__DNA Binding_PMIDS:16229683 Yes 4a, two or more datasets predict it as a TF Sam Lambert Yimeng Yin No $#ENSG00000185920#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#IMP - PMID:16229683 $#ENSP00000364420#ENSG00000185920#ENST00000375271#Other#Patched, Sterol-sensing$#ENSP00000414823#ENSG00000185920#ENST00000429896#Other#Patched, Sterol-sensing$#ENSP00000449745#ENSG00000185920#ENST00000468211#Other#$#ENSP00000448843#ENSG00000185920#ENST00000546820#Other#$#ENSP00000447878#ENSG00000185920#ENST00000547672#Other#$#ENSP00000450131#ENSG00000185920#ENST00000551630#Other#$#ENSP00000447797#ENSG00000185920#ENST00000553011#Other# FALSE 2415 ENSG00000171862 PTEN Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000008;IPR000340;IPR003595;IPR014020;IPR016130;IPR017361;IPR029021;IPR029023 5728 phosphatase and tensin homolog [Source:HGNC Symbol;Acc:HGNC:9588];Phosphatidylinositol 3,4,5-trispho None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Jussi Taipale Matt Weirauch No $#ENSG00000171862#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IMP - PMID:20123964 $#ENSP00000361021#ENSG00000171862#ENST00000371953#Other#DSPc, PTEN_C2, PTPlike_phytase, Y_phosphatase, Y_p$#ENSP00000483066#ENSG00000171862#ENST00000472832#Other#DUF3256, PTEN_C2$#ENSP00000477517#ENSG00000171862#ENST00000610634#Other#DSPc, PTPlike_phytase, Y_phosphatase, Y_phosphatas FALSE 2416 ENSG00000124212 PTGIS Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None It is a cytochrome p450 enzyme IPR001128;IPR002403;IPR024204;IPR027286 5740 prostaglandin I2 (prostacyclin) synthase [Source:HGNC Symbol;Acc:HGNC:9603];Prostacyclin synthase None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Arttu Jolma Yimeng Yin No $#ENSG00000124212#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IDA - PMID:20159982 $#ENSP00000244043#ENSG00000124212#ENST00000244043#Other#p450 FALSE 2417 ENSG00000152266 PTH Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR001415;IPR003625 5741 parathyroid hormone [Source:HGNC Symbol;Acc:HGNC:9606] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Laura Campitelli Matt Weirauch No $#ENSG00000152266#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#IMP - PMID:17696759 $#ENSP00000282091#ENSG00000152266#ENST00000282091#Other#ABC_ATPase, Parathyroid$#ENSP00000433208#ENSG00000152266#ENST00000529816#Other#ABC_ATPase, Parathyroid FALSE 2418 ENSG00000164611 PTTG1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None GO annotation has no evidence for DNA-binding activity (PMID:9811450), only transcriptional activation in reporter experiments IPR006940 9232 pituitary tumor-transforming 1 [Source:HGNC Symbol;Acc:HGNC:9690] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Sam Lambert Matt Weirauch No $#ENSG00000164611#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:9811450 $#ENSP00000344936#ENSG00000164611#ENST00000352433#Other#Securin$#ENSP00000377536#ENSG00000164611#ENST00000393964#Other#Securin$#ENSP00000430642#ENSG00000164611#ENST00000520452#Other#Securin$#ENSP00000431068#ENSG00000164611#ENST00000517480#Other#Securin FALSE 2419 ENSG00000080608 PUM3 Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None Binds dsDNA in the crystal structure (PDB: 4WZW). Makes extensive contacts with the backbone that cause shape changes and could possibly lead to specificity. None 9933 pumilio RNA binding family member 3 4WZW not tested not tested None Binds dsDNA in the crystal structure (PDB: 4WZW). Makes extensive contacts with the backbone that cause shape changes and could possibly lead to specificity. No No No No New proteins added based on PDB entry Arttu Jolma Sam Lambert No None None FALSE 2420 ENSG00000185129 PURA Unknown Yes Known motif Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain Binds dsDNA (PMID: 15282343) and ssDNA (PMID: 1448097) specifically IPR006628 5813 purine rich element binding protein A [Source:HGNC Symbol;Acc:HGNC:9701];Transcriptional activator p None not tested not tested None None No Yes TF Gene_Single stranded RNA/DNA binding_DNA Binding_PMIDS:1448097;1545807;15282343 Yes 2a1, Lower confidence direct evidence Pratyush Das Sam Lambert Yes $#ENSG00000185129#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#TAS - PMID:9334258 $#ENSP00000332706#ENSG00000185129#ENST00000331327#Other#DUF3276, PurA FALSE 2421 ENSG00000146676 PURB Unknown Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Binds dsDNA (PMID: 15282343) and ssDNA (PMID: 1448097) specifically IPR006628 100616393 purine rich element binding protein B [Source:HGNC Symbol;Acc:HGNC:9702] None not tested not tested None None No No TF Gene_Single stranded RNA/DNA binding_DNA Binding_PMIDS:15282343 No 5a, one of the source datasets predicts is as a TF Laura Campitelli Arttu Jolma Yes $#ENSG00000146676#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IEA - GO_REF:0000019 $##ENSG00000146676##Other# FALSE 2422 ENSG00000172733 PURG Unknown Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Paralogs PURA and PURB bind dsDNA (PMID: 15282343) and ssDNA (PMID: 1448097) specifically. IPR006628 29942 Purine rich element binding protein G None not tested not tested None Paralogs PURA and PURB bind dsDNA (PMID: 15282343) and ssDNA (PMID: 1448097) specifically. No No No No New proteins added after initial stage Arttu Jolma Sam Lambert Yes None None FALSE 2423 ENSG00000103490 PYCARD Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR001315;IPR004020;IPR011029 29108 PYD and CARD domain containing [Source:HGNC Symbol;Acc:HGNC:16608];Apoptosis-associated speck-like p None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Pratyush Das Sam Lambert No $#ENSG00000103490#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IMP - PMID:16585594$#ENSG00000103490#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:19494289$#ENSG00000103490#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IDA - PMID:12646168, PMID:12656673 $#ENSP00000247470#ENSG00000103490#ENST00000247470#Other#CARD, PYRIN$#ENSP00000340441#ENSG00000103490#ENST00000350605#Other#CARD, PYRIN$#ENSP00000455141#ENSG00000103490#ENST00000561508#Other#PYRIN FALSE 2424 ENSG00000169900 PYDC1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR004020;IPR011029 260434 pyrin domain containing 1 [Source:HGNC Symbol;Acc:HGNC:30261] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Sam Lambert Matt Weirauch No $#ENSG00000169900#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IDA - PMID:12656673 | IMP - PMID:24871464 $#ENSP00000304336#ENSG00000169900#ENST00000302964#Other#PYRIN FALSE 2425 ENSG00000253548 PYDC2 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Protein that regulates NFKB activity IPR004020;IPR011029 None pyrin domain containing 2 [Source:HGNC Symbol;Acc:HGNC:33512] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Sam Lambert Arttu Jolma No $#ENSG00000253548#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IMP - PMID:17339483, PMID:24871464 $##ENSG00000253548##Other# FALSE 2426 ENSG00000198218 QRICH1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR001315;IPR011029;IPR021893 54870 glutamine rich 1 [Source:HGNC Symbol;Acc:HGNC:24713] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Yimeng Yin Jussi Taipale No $#ENSG00000198218#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000378830#ENSG00000198218#ENST00000395443#Other#CARD, DUF3504$#ENSP00000350094#ENSG00000198218#ENST00000357496#Other#CARD, DUF3504$#ENSP00000412890#ENSG00000198218#ENST00000424300#Other#CARD, DUF3504$#ENSP00000413051#ENSG00000198218#ENST00000450685#Other#CARD FALSE 2427 ENSG00000276600 RAB7B Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Protein activates NFKB (PMID: 20953574) IPR001806;IPR002041;IPR003578;IPR003579;IPR005225;IPR020849;IPR027417 338382 RAB7B, member RAS oncogene family [Source:HGNC Symbol;Acc:HGNC:30513] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Yimeng Yin Arttu Jolma No $#ENSG00000276600#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IMP - PMID:20953574 $#ENSP00000482499#ENSG00000276600#ENST00000617070#Other#ATP_bind_1, Arf, DUF258, G-alpha, GTP_EFTU, Gtr1_R$#ENSP00000479762#ENSG00000276600#ENST00000617991#Other#ATP_bind_1, Arf, DUF258, G-alpha, GTP_EFTU, Gtr1_R$#ENSP00000485563#ENSG00000276600#ENST00000622969#Other#Ras$#ENSP00000485386#ENSG00000276600#ENST00000623893#Other#AAA_22, ATP_bind_1, Arf, G-alpha, GTP_EFTU, Gtr1_R FALSE 2428 ENSG00000164754 RAD21 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Motifs are suspicious; protein is a component of the cohesin complex and there is no evidence for direct binding to DNA. IPR006909;IPR006910 100500914 RAD21 cohesin complex component [Source:HGNC Symbol;Acc:HGNC:9811] None not tested not tested None None No Yes No No 2a1, Lower confidence direct evidence Yimeng Yin Arttu Jolma No $#ENSG00000164754#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IEA - GO_REF:0000019 $#ENSP00000297338#ENSG00000164754#ENST00000297338#Other#Rad21_Rec8, Rad21_Rec8_N, SMC_ScpA$#ENSP00000430273#ENSG00000164754#ENST00000517749#Other#Rad21_Rec8, SMC_ScpA$#ENSP00000428003#ENSG00000164754#ENST00000518055#Other#Rad21_Rec8, SMC_ScpA$#ENSP00000428513#ENSG00000164754#ENST00000523986#Other#Rad21_Rec8, SMC_ScpA$#ENSP00000427923#ENSG00000164754#ENST00000517485#Other#Rad21_Rec8_N$#ENSP00000428158#ENSG00000164754#ENST00000522699#Other#Rad21_Rec8_N FALSE 2429 ENSG00000051180 RAD51 Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None Functions in homologous recombination DNA-repair. Binds DNA with low specificity (PMID:10390347) IPR003593;IPR010995;IPR011941;IPR013632;IPR016467;IPR020587;IPR020588;IPR027417 5888 RAD51 recombinase [Source:HGNC Symbol;Acc:HGNC:9817] None Full not tested None None x No No No 5a, one of the source datasets predicts is as a TF Arttu Jolma Sam Lambert No None $#ENSP00000267868#ENSG00000051180#ENST00000267868#Other#AAA_25, ATPase, HHH_5, Rad51, RecA$#ENSP00000406602#ENSG00000051180#ENST00000423169#Other#AAA_25, ATPase, HHH_5, Rad51, RecA$#ENSP00000372088#ENSG00000051180#ENST00000382643#Other#AAA_25, HHH_5, Rad51, RecA$#ENSP00000433924#ENSG00000051180#ENST00000532743#Other#AAA_25, HHH_5, Rad51, RecA$#ENSP00000454176#ENSG00000051180#ENST00000557850#Other#AAA_25, HHH_5, Rad51$#ENSP00000431897#ENSG00000051180#ENST00000526763#Other#HHH_5 FALSE 2430 ENSG00000166349 RAG1 Unknown Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Binds DNA specifically (PMID: 10066757) IPR001841;IPR017907;IPR018957;IPR019485;IPR023336;IPR024627 5896 recombination activating gene 1 [Source:HGNC Symbol;Acc:HGNC:9831] 3GNA not tested not tested None Protein contacts DNA in the structure;Operates in lymphocyte development in a process known as V(D)J recombination x No No No 1a1, Direct HQ evidence Pratyush Das Yimeng Yin No None $#ENSP00000299440#ENSG00000166349#ENST00000299440#Other#RAG1, RAG1_imp_bd, zf-C3HC4, zf-C3HC4_2, zf-C3HC4_ FALSE 2431 ENSG00000108557 RAI1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Chromatin remodeler IPR001965 10743 retinoic acid induced 1 [Source:HGNC Symbol;Acc:HGNC:9834] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Tim Hughes Matt Weirauch No $#ENSG00000108557#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000323074#ENSG00000108557#ENST00000353383#Other#zf-HC5HC2H, zf-HC5HC2H_2$#ENSP00000379120#ENSG00000108557#ENST00000395774#Other#$#ENSP00000463984#ENSG00000108557#ENST00000583166#Other#zf-HC5HC2H, zf-HC5HC2H_2$#ENSP00000463607#ENSG00000108557#ENST00000471135#Other# FALSE 2432 ENSG00000079337 RAPGEF3 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None No DBD and no evidence its a TF - included only because it has an x in Vaquerizas 2009 IPR000591;IPR000595;IPR000651;IPR001895;IPR002373;IPR018490;IPR019804;IPR029071 10411 Rap guanine nucleotide exchange factor 3 [Source:HGNC Symbol;Acc:HGNC:16629] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Pratyush Das Tim Hughes No None $#ENSP00000373864#ENSG00000079337#ENST00000389212#Other#DEP, RasGEF, RasGEF_N, cNMP_binding$#ENSP00000378764#ENSG00000079337#ENST00000395358#Other#DEP, RasGEF_N, cNMP_binding$#ENSP00000395708#ENSG00000079337#ENST00000449771#Other#DEP, RasGEF, RasGEF_N, cNMP_binding$#ENSP00000448480#ENSG00000079337#ENST00000548919#Other#DEP, RasGEF, RasGEF_N, cNMP_binding$#ENSP00000448804#ENSG00000079337#ENST00000495953#Other#DEP FALSE 2433 ENSG00000091428 RAPGEF4 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000159;IPR000591;IPR000595;IPR000651;IPR001895;IPR002373;IPR018490;IPR019804;IPR029071; 11069 Rap guanine nucleotide exchange factor 4 [Source:HGNC Symbol;Acc:HGNC:16626] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Sam Lambert Pratyush Das No None $#ENSP00000380271#ENSG00000091428#ENST00000397081#Other#DEP, RasGEF, RasGEF_N, cNMP_binding$#ENSP00000380276#ENSG00000091428#ENST00000397087#Other#DEP, RasGEF, RasGEF_N, cNMP_binding$#ENSP00000438011#ENSG00000091428#ENST00000535187#Other#DEP, RasGEF, RasGEF_N, cNMP_binding$#ENSP00000440135#ENSG00000091428#ENST00000538974#Other#DEP, RasGEF, RasGEF_N, cNMP_binding$#ENSP00000440250#ENSG00000091428#ENST00000540783#Other#DEP, RasGEF, RasGEF_N, cNMP_binding$#ENSP00000380274#ENSG00000091428#ENST00000397085#Other#RasGEF FALSE 2434 ENSG00000136237 RAPGEF5 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000591;IPR000651;IPR001895;IPR019804;IPR029071; 9771 Rap guanine nucleotide exchange factor 5 [Source:HGNC Symbol;Acc:HGNC:16862] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Laura Campitelli Pratyush Das No None $#ENSP00000384044#ENSG00000136237#ENST00000401957#Other#RA, RasGEF, RasGEF_N$#ENSP00000384870#ENSG00000136237#ENST00000405243#Other#DEP$#ENSP00000479340#ENSG00000136237#ENST00000620335#Other#RasGEF, RasGEF_N FALSE 2435 ENSG00000139687 RB1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Classic co-factor IPR002719;IPR002720;IPR013763;IPR015030;IPR024599 5925 RB transcriptional corepressor 1 [Source:HGNC Symbol;Acc:HGNC:9884];Retinoblastoma-associated protei None not tested not tested None None No No TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI; Transactivation_PMIDS:16007137 Yes 4a, two or more datasets predict it as a TF Matt Weirauch Laura Campitelli No $#ENSG00000139687#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:3657987$#ENSG00000139687#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#TAS - PMID:9529249 $#ENSP00000267163#ENSG00000139687#ENST00000267163#Other#DUF3452, RB_A, RB_B, Rb_C FALSE 2436 ENSG00000102054 RBBP7 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR001680;IPR017986;IPR019775;IPR020472;IPR022052 5931 RB binding protein 7, chromatin remodeling factor [Source:HGNC Symbol;Acc:HGNC:9890] None not tested not tested None None No No TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:16950772 No 5a, one of the source datasets predicts is as a TF Matt Weirauch Yimeng Yin No None $##ENSG00000102054##Other# FALSE 2437 ENSG00000125826 RBCK1 Unknown Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Fairly well-studied E3 ubiquitin-protein ligase. But EMSA data exist demonstrating binding to TGG-containing DNA (PMID: 9514928) IPR000626;IPR001841;IPR001876;IPR002867;IPR017907;IPR029071 10616 RANBP2-type and C3HC4-type zinc finger containing 1 [Source:HGNC Symbol;Acc:HGNC:15864] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Pratyush Das Yimeng Yin No $#ENSG00000125826#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IDA - PMID:17449468$#ENSG00000125826#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IDA - PMID:19136968 $#ENSP00000254960#ENSG00000125826#ENST00000353660#Other#IBR, ubiquitin, zf-C3HC4_2, zf-C3HC4_4, zf-RING_11$#ENSP00000348632#ENSG00000125826#ENST00000356286#Other#IBR, ubiquitin, zf-C3HC4_2, zf-C3HC4_4, zf-RING_11$#ENSP00000371616#ENSG00000125826#ENST00000382181#Other#IBR$#ENSP00000417173#ENSG00000125826#ENST00000475269#Other#$#ENSP00000383106#ENSG00000125826#ENST00000400247#Other#$#ENSP00000415080#ENSG00000125826#ENST00000411647#Other#ubiquitin$#ENSP00000393841#ENSG00000125826#ENST00000414880#Other#ubiquitin, zf-RanBP FALSE 2438 ENSG00000080839 RBL1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR002719;IPR002720;IPR013763;IPR015030;IPR024599 5933 RB transcriptional corepressor like 1 [Source:HGNC Symbol;Acc:HGNC:9893] None not tested not tested None None No No TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_DNA Binding; Other_PMIDS:14716294 No 5a, one of the source datasets predicts is as a TF Yimeng Yin Sam Lambert No None $##ENSG00000080839##Other# FALSE 2439 ENSG00000103479 RBL2 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Transcriptional co-repressor IPR002719;IPR002720;IPR013763;IPR024599 5934 RB transcriptional corepressor like 2 [Source:HGNC Symbol;Acc:HGNC:9894] None not tested not tested None None No No Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0 No 5a, one of the source datasets predicts is as a TF Pratyush Das Arttu Jolma No None $##ENSG00000103479##Other# FALSE 2440 ENSG00000182872 RBM10 Unknown No ssDNA/RNA binding Not a DNA binding protein No motif None RNA-binding protein IPR000467;IPR000504;IPR001876;IPR007087 8241 RNA binding motif protein 10 [Source:HGNC Symbol;Acc:HGNC:9896] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Sam Lambert Laura Campitelli No None $#ENSP00000328848#ENSG00000182872#ENST00000329236#Other#G-patch, G-patch_2, zf-RanBP$#ENSP00000366829#ENSG00000182872#ENST00000377604#Other#G-patch, G-patch_2, zf-RanBP$#ENSP00000486115#ENSG00000182872#ENST00000628161#Other#G-patch, G-patch_2, zf-RanBP$#ENSP00000329659#ENSG00000182872#ENST00000345781#Other#G-patch, G-patch_2, zf-RanBP FALSE 2441 ENSG00000203867 RBM20 Unknown No ssDNA/RNA binding Not a DNA binding protein No motif None Likely an RNA-binding protein IPR000504;IPR000690;IPR003604; 282996 RNA binding motif protein 20 [Source:HGNC Symbol;Acc:HGNC:27424] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Sam Lambert Pratyush Das No None $#ENSP00000358532#ENSG00000203867#ENST00000369519#Other#RRM_5, zf-C2H2_jaz FALSE 2442 ENSG00000086589 RBM22 Unknown No ssDNA/RNA binding Not a DNA binding protein No motif None RNA binding protein (PMID: 17045351) IPR000504;IPR000571 55696 RNA binding motif protein 22 [Source:HGNC Symbol;Acc:HGNC:25503] None not tested Yes None None x No No No 5a, one of the source datasets predicts is as a TF Tim Hughes Pratyush Das No None $#ENSP00000199814#ENSG00000086589#ENST00000199814#Other#FYVE$#ENSP00000412118#ENSG00000086589#ENST00000447771#Other#$#ENSP00000430946#ENSG00000086589#ENST00000521464#Other#$#ENSP00000428154#ENSG00000086589#ENST00000518917#Other# FALSE 2443 ENSG00000139746 RBM26 Unknown No ssDNA/RNA binding Not a DNA binding protein No motif None RNA-binding protein (PMID: 22681889; PMID: 22658674) IPR000504;IPR000571;IPR002483; 64062 RNA binding motif protein 26 [Source:HGNC Symbol;Acc:HGNC:20327] None Full not tested None None x No No No 5a, one of the source datasets predicts is as a TF Laura Campitelli Arttu Jolma No None $#ENSP00000267229#ENSG00000139746#ENST00000267229#Other#PWI$#ENSP00000390222#ENSG00000139746#ENST00000438724#Other#PWI$#ENSP00000483408#ENSG00000139746#ENST00000622611#Other#PWI$#ENSP00000401474#ENSG00000139746#ENST00000449987#Other# FALSE 2444 ENSG00000091009 RBM27 Unknown No ssDNA/RNA binding Not a DNA binding protein No motif None Likely an RNA-binding protein IPR000504;IPR000571;IPR002483; 54439 RNA binding motif protein 27 [Source:HGNC Symbol;Acc:HGNC:29243] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Jussi Taipale Matt Weirauch No None $#ENSP00000265271#ENSG00000091009#ENST00000265271#Other#PWI FALSE 2445 ENSG00000003756 RBM5 Unknown No ssDNA/RNA binding Not a DNA binding protein No motif None RNA-binding protein that binds RNA with two RRM-domains and regulates splicing (PMID: 24486491) IPR000467;IPR000504;IPR001876;IPR007087 10181 RNA binding motif protein 5 [Source:HGNC Symbol;Acc:HGNC:9902] None not tested not tested None Has only a single ZNFC2H2 x No No No 5a, one of the source datasets predicts is as a TF Arttu Jolma Tim Hughes No None $#ENSP00000343054#ENSG00000003756#ENST00000347869#Other#G-patch, G-patch_2, zf-RanBP$#ENSP00000419534#ENSG00000003756#ENST00000469838#Other#$#ENSP00000384872#ENSG00000003756#ENST00000404526#Other#$#ENSP00000390711#ENSG00000003756#ENST00000441305#Other# FALSE 2446 ENSG00000004534 RBM6 Unknown No ssDNA/RNA binding Not a DNA binding protein No motif None RNA-binding protein that binds RNA with two RRM-domains and regulates splicing (PMID: 24332178) IPR000467;IPR000504 10180 RNA binding motif protein 6 [Source:HGNC Symbol;Acc:HGNC:9903] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Arttu Jolma Matt Weirauch No None $#ENSP00000266022#ENSG00000004534#ENST00000266022#Other#G-patch, Pentapeptide_4$#ENSP00000393530#ENSG00000004534#ENST00000442092#Other#G-patch$#ENSP00000392475#ENSG00000004534#ENST00000421682#Other#G-patch$#ENSP00000392939#ENSG00000004534#ENST00000422955#Other#G-patch$#ENSP00000389763#ENSG00000004534#ENST00000433811#Other# FALSE 2447 ENSG00000159200 RCAN1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None SH3 domain protein that interacts with calcineurin. GO annotation and abstract in (PMID: 8595418) appear erroneous - mentions a binding domain in the abstract, but no evidence is provided in the paper. IPR006931 1827 regulator of calcineurin 1 [Source:HGNC Symbol;Acc:HGNC:3040];Calcipressin-1 None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Jussi Taipale Matt Weirauch No $#ENSG00000159200#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:8595418 $#ENSP00000320768#ENSG00000159200#ENST00000313806#Other#Calcipressin$#ENSP00000370524#ENSG00000159200#ENST00000381132#Other#Calcipressin$#ENSP00000382214#ENSG00000159200#ENST00000399272#Other#Calcipressin$#ENSP00000392438#ENSG00000159200#ENST00000443408#Other#Calcipressin$#ENSP00000419624#ENSG00000159200#ENST00000482533#Other#Calcipressin$#ENSP00000370527#ENSG00000159200#ENST00000381135#Other#Calcipressin$#ENSP00000419252#ENSG00000159200#ENST00000487990#Other#Calcipressin$#ENSP00000477155#ENSG00000159200#ENST00000492600#Other#Calcipressin FALSE 2448 ENSG00000004700 RECQL Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None ATP dependent DNA helicase. Binds DNA in the crystal structure (PDB: 2WWY) None 5965 RecQ like helicase 2WWY not tested not tested None None No No No No New proteins added based on PDB entry Arttu Jolma Sam Lambert No None None FALSE 2449 ENSG00000164620 RELL2 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR022248; 285613 RELT like 2 [Source:HGNC Symbol;Acc:HGNC:26902] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Sam Lambert Pratyush Das No None $#ENSP00000297164#ENSG00000164620#ENST00000297164#Other#RELT$#ENSP00000409443#ENSG00000164620#ENST00000444782#Other#RELT$#ENSP00000427992#ENSG00000164620#ENST00000518856#Other#$#ENSP00000430948#ENSG00000164620#ENST00000521367#Other# FALSE 2450 ENSG00000189056 RELN Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Protein is a large secreted extracellular matrix protein IPR000742;IPR002861;IPR011040;IPR013032 5649 reelin [Source:HGNC Symbol;Acc:HGNC:9957] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Arttu Jolma Jussi Taipale No $#ENSG00000189056#GO:0032793#positive regulation of CREB transcription factor activity#ISS - GO_REF:0000024 $#ENSP00000345694#ENSG00000189056#ENST00000343529#Other#BNR, EGF_2, Reeler$#ENSP00000388446#ENSG00000189056#ENST00000424685#Other#BNR, EGF_2, Reeler$#ENSP00000392423#ENSG00000189056#ENST00000428762#Other#BNR, EGF_2, Reeler$#ENSP00000404818#ENSG00000189056#ENST00000429186#Other# FALSE 2451 ENSG00000135945 REV1 Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None DNA polymerase. Binds DNA in the crystal structure (PDB: 3GQC) None 51455 REV1, DNA directed polymerase 3GQC not tested not tested None None No No No No New proteins added based on PDB entry Arttu Jolma Sam Lambert No None None FALSE 2452 ENSG00000148300 REXO4 Unknown Yes Likely to be sequence specific TF Low specificity DNA-binding protein No motif None REXO4 (hPMC2) has been shown to bind ERE containing sequences in gel-shift experiments (PMID: 10908561) in complex with ERbeta. However, figures containing the gel-shifts have been cropped to exclude the unshifted free DNA band so it is hard to judge the evidence. IPR006055;IPR012337;IPR013520 57109 REX4 homolog, 3-5 exonuclease [Source:HGNC Symbol;Acc:HGNC:12820] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Sam Lambert Pratyush Das No $#ENSG00000148300#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:10908561 $#ENSP00000361010#ENSG00000148300#ENST00000371942#Other#RNase_T$#ENSP00000361003#ENSG00000148300#ENST00000371935#Other#RNase_T$#ENSP00000391534#ENSG00000148300#ENST00000445916#Other#$#ENSP00000394229#ENSG00000148300#ENST00000454825#Other#RNase_T FALSE 2453 ENSG00000035928 RFC1 Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None DNA-dependent ATPase. Binds DNA (contact with major groove and backbone) in the crystal structure (PDB: 2K7F) None 5981 replication factor C subunit 1 2K7F not tested not tested None None No No No No New proteins added based on PDB entry Arttu Jolma Sam Lambert No None None FALSE 2454 ENSG00000064490 RFXANK Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None AKA RFX-B. No DBD, no motifs produced when tested, no evidence of independent DNA binding. (PMID: 9806546) shows that its interaction with RFX5 and RFXAP is essential for binding of the RFX complex to MHC-II promoters, but it does not bind DNA on its own. IPR002110;IPR017362;IPR020683; 8625 regulatory factor X associated ankyrin containing protein [Source:HGNC Symbol;Acc:HGNC:9987] None DBD and Full not tested None PMID:20637319 shows that RFXANK is a cofactor of RFX-proteins that binds them with PPI and DNA doesnt contribute to the complex formation other No TF Gene_Transcription Factor Binding: tf co-factor binding_DNA Binding_PMIDS:1505028;9806546 Yes 4a, two or more datasets predict it as a TF Matt Weirauch Tim Hughes Yes $#ENSG00000064490#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:9806546 $#ENSP00000305071#ENSG00000064490#ENST00000303088#Other#Ank, Ank_2, Ank_3, Ank_4, Ank_5$#ENSP00000376138#ENSG00000064490#ENST00000392324#Other#Ank, Ank_2, Ank_3, Ank_4, Ank_5$#ENSP00000384572#ENSG00000064490#ENST00000407360#Other#Ank, Ank_2, Ank_3, Ank_4, Ank_5$#ENSP00000409138#ENSG00000064490#ENST00000456252#Other#Ank, Ank_2, Ank_3, Ank_4, Ank_5$#ENSP00000444280#ENSG00000064490#ENST00000535017#Other#Ank, Ank_2, Ank_3, Ank_4, Ank_5$#ENSP00000466913#ENSG00000064490#ENST00000593273#Other#Ank_2, Ank_4, Ank_5 FALSE 2455 ENSG00000133111 RFXAP Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Included because TF-CAT calls it a cofactor and GO erroneously calls it sequence-specific DNA binding. Based on PMID:20732328 it forms protei-protein interactions with RFX5, unlikely to contribute to Protein-DNA interaction IPR029316 5994 regulatory factor X associated protein [Source:HGNC Symbol;Acc:HGNC:9988] None not tested not tested None None No No TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:11486010 Yes 4a, two or more datasets predict it as a TF Tim Hughes Laura Campitelli Yes $#ENSG00000133111#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:9118943 $#ENSP00000255476#ENSG00000133111#ENST00000255476#Other#RFXA_RFXANK_bdg FALSE 2456 ENSG00000102760 RGCC Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR029252 28984 regulator of cell cycle [Source:HGNC Symbol;Acc:HGNC:20369];Regulator of cell cycle RGCC None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Jussi Taipale Sam Lambert No $#ENSG00000102760#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IMP - PMID:19158077 $#ENSP00000368664#ENSG00000102760#ENST00000379359#Other#RGCC FALSE 2457 ENSG00000076344 RGS11 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif Has a putative AT-hook None IPR000591;IPR015898;IPR016137; 8786 regulator of G-protein signaling 11 [Source:HGNC Symbol;Acc:HGNC:9993] None Full not tested None None x No No No 5a, one of the source datasets predicts is as a TF Pratyush Das Sam Lambert No None $#ENSP00000319069#ENSG00000076344#ENST00000316163#Other#DEP, G-gamma, RGS$#ENSP00000352778#ENSG00000076344#ENST00000359740#Other#DEP, G-gamma, RGS$#ENSP00000380876#ENSG00000076344#ENST00000397770#Other#DEP, G-gamma, RGS FALSE 2458 ENSG00000182732 RGS6 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000591;IPR015898;IPR016137; 9628 regulator of G-protein signaling 6 [Source:HGNC Symbol;Acc:HGNC:10002] None Full not tested None None x No No No 5a, one of the source datasets predicts is as a TF Pratyush Das Laura Campitelli No None $#ENSP00000347699#ENSG00000182732#ENST00000355512#Other#DEP, G-gamma, RGS$#ENSP00000383953#ENSG00000182732#ENST00000402788#Other#DEP, G-gamma, RGS$#ENSP00000385243#ENSG00000182732#ENST00000404301#Other#DEP, G-gamma, RGS$#ENSP00000384218#ENSG00000182732#ENST00000406236#Other#DEP, G-gamma, RGS$#ENSP00000384612#ENSG00000182732#ENST00000407322#Other#DEP, G-gamma, RGS$#ENSP00000452331#ENSG00000182732#ENST00000553530#Other#DEP, G-gamma, RGS$#ENSP00000451912#ENSG00000182732#ENST00000554782#Other#G-gamma, RGS$#ENSP00000450936#ENSG00000182732#ENST00000555571#Other#DEP, G-gamma, RGS$#ENSP00000451855#ENSG00000182732#ENST00000556437#Other#DEP, G-gamma, RGS$#ENSP00000478186#ENSG00000182732#ENST00000622468#Other#DEP, G-gamma, RGS$#ENSP00000412144#ENSG00000182732#ENST00000434263#Other#DEP, G-gamma, RGS$#ENSP00000451030#ENSG00000182732#ENST00000553525#Other#DEP, G-gamma, RGS FALSE 2459 ENSG00000182901 RGS7 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000591;IPR015898;IPR016137; 6000 regulator of G-protein signaling 7 [Source:HGNC Symbol;Acc:HGNC:10003] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Laura Campitelli Jussi Taipale No None $#ENSP00000341242#ENSG00000182901#ENST00000348120#Other#DEP, G-gamma, RGS, RGS-like$#ENSP00000355522#ENSG00000182901#ENST00000366564#Other#DEP, G-gamma, RGS, RGS-like$#ENSP00000355523#ENSG00000182901#ENST00000366565#Other#DEP, G-gamma, RGS, RGS-like$#ENSP00000404399#ENSG00000182901#ENST00000440928#Other#G-gamma, RGS, RGS-like FALSE 2460 ENSG00000108370 RGS9 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000591;IPR015898;IPR016137; 8787 regulator of G-protein signaling 9 [Source:HGNC Symbol;Acc:HGNC:10004] None Full not tested None None x No No No 5a, one of the source datasets predicts is as a TF Yimeng Yin Jussi Taipale No None $#ENSP00000262406#ENSG00000108370#ENST00000262406#Other#DEP, G-gamma, RGS$#ENSP00000405814#ENSG00000108370#ENST00000443584#Other#DEP, G-gamma, RGS$#ENSP00000396329#ENSG00000108370#ENST00000449996#Other#DEP, G-gamma, RGS$#ENSP00000490658#ENSG00000108370#ENST00000635833#Other#DEP, G-gamma, RGS FALSE 2461 ENSG00000167550 RHEBL1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR001806;IPR003578;IPR003579;IPR005225;IPR020849;IPR027417 121268 Ras homolog enriched in brain like 1 [Source:HGNC Symbol;Acc:HGNC:21166];GTPase RhebL1 None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Sam Lambert Laura Campitelli No $#ENSG00000167550#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IDA - PMID:16328882 $#ENSP00000301068#ENSG00000167550#ENST00000301068#Other#Arf, DUF258, GTP_EFTU, MMR_HSR1, Ras, Roc, SRPRB$#ENSP00000447428#ENSG00000167550#ENST00000550675#Other#Arf, MMR_HSR1, Ras, Roc, SRPRB FALSE 2462 ENSG00000204227 RING1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None RING1 is a well-characterized member of the Polycomb complex. No reference to DNA-binding in literature search on EntrezGene IPR001841;IPR017907;IPR018957 6015 ring finger protein 1 [Source:HGNC Symbol;Acc:HGNC:10018] None not tested not tested None None No No TF Gene_Transcription Factor Binding: tf co-factor binding_Transactivation_PMIDS:9312051;9858531;12482919;14999091 No 5a, one of the source datasets predicts is as a TF Sam Lambert Yimeng Yin No None $##ENSG00000204227##Other# FALSE 2463 ENSG00000058729 RIOK2 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000687;IPR011009;IPR015285;IPR018934;IPR018935; 55781 RIO kinase 2 [Source:HGNC Symbol;Acc:HGNC:18999] None Full Yes None None x No No No 5a, one of the source datasets predicts is as a TF Arttu Jolma Laura Campitelli No None $#ENSP00000283109#ENSG00000058729#ENST00000283109#Other#APH, Kdo, RIO1, Rio2_N$#ENSP00000420932#ENSG00000058729#ENST00000508447#Other#APH, Kdo, RIO1, Rio2_N$#ENSP00000422772#ENSG00000058729#ENST00000511012#Other#$#ENSP00000421830#ENSG00000058729#ENST00000511293#Other# FALSE 2464 ENSG00000137275 RIPK1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000488;IPR000719;IPR001245;IPR002290;IPR008271;IPR011009;IPR011029;IPR025735 8737 receptor interacting serine/threonine kinase 1 [Source:HGNC Symbol;Acc:HGNC:10019] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Laura Campitelli Sam Lambert No $#ENSG00000137275#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IMP - PMID:10521396, PMID:21931591, PMID:8612133 $#ENSP00000369773#ENSG00000137275#ENST00000380409#Other#Death, Kinase-like, Pkinase, Pkinase_Tyr, RHIM$#ENSP00000259808#ENSG00000137275#ENST00000259808#Other#Death, Kinase-like, Pkinase, Pkinase_Tyr, RHIM FALSE 2465 ENSG00000104312 RIPK2 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Protein activates NFKB through its kinase activity IPR000719;IPR001315;IPR002290;IPR008271;IPR011009;IPR011029;IPR017322 8767 receptor interacting serine/threonine kinase 2 [Source:HGNC Symbol;Acc:HGNC:10020] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Arttu Jolma Pratyush Das No $#ENSG00000104312#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IMP - PMID:21887730, PMID:21931591 | TAS - Reactom $#ENSP00000220751#ENSG00000104312#ENST00000220751#Other#CARD, Pkinase, Pkinase_Tyr FALSE 2466 ENSG00000129465 RIPK3 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Kinase protein IPR000719;IPR002290;IPR008271;IPR011009;IPR017441;IPR025735 11035 receptor interacting serine/threonine kinase 3 [Source:HGNC Symbol;Acc:HGNC:10021] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Sam Lambert Arttu Jolma No $#ENSG00000129465#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IDA - PMID:21931591 $#ENSP00000216274#ENSG00000129465#ENST00000216274#Other#APH, Pkinase, Pkinase_Tyr, RHIM$#ENSP00000451840#ENSG00000129465#ENST00000554569#Other#RHIM FALSE 2467 ENSG00000183421 RIPK4 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000719;IPR002110;IPR002290;IPR008271;IPR011009;IPR017441;IPR020683 54101 receptor interacting serine/threonine kinase 4 [Source:HGNC Symbol;Acc:HGNC:496] None not tested not tested None None No No Probably Not a TF - No evidence that it is a TF___PMIDS:0 Yes 5a, one of the source datasets predicts is as a TF Yimeng Yin Laura Campitelli No $#ENSG00000183421#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IMP - PMID:21931591 $#ENSP00000332454#ENSG00000183421#ENST00000332512#Other#Ank, Ank_2, Ank_3, Ank_4, Ank_5, Pkinase, Pkinase_$#ENSP00000330161#ENSG00000183421#ENST00000352483#Other#Ank, Ank_2, Ank_3, Ank_4, Ank_5, Pkinase, Pkinase_ FALSE 2468 ENSG00000131263 RLIM Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None LIM ZF proteins are unlikely to bind DNA None 51132 E3 ubiquitin-protein ligase RLIM None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Sam Lambert Yimeng Yin No $#ENSG00000131263#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019 $##ENSG00000131263##Other# FALSE 2469 ENSG00000169385 RNASE2 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR001427;IPR023411;IPR023412; 6036 ribonuclease A family member 2 [Source:HGNC Symbol;Acc:HGNC:10045] None Full not tested None None x No No No 5a, one of the source datasets predicts is as a TF Laura Campitelli Pratyush Das No None $#ENSP00000303276#ENSG00000169385#ENST00000304625#Other#RnaseA FALSE 2470 ENSG00000171865 RNASEH1 Unknown No ssDNA/RNA binding Not a DNA binding protein No motif None Ribonuclease H1. Binds DNA-RNA hybrid in structure (PDB: 2QKB) None 246243 ribonuclease H1 2QKB not tested not tested None None No No No No New proteins added based on PDB entry Arttu Jolma Sam Lambert No None None FALSE 2471 ENSG00000124226 RNF114 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR001841;IPR008598;IPR017907;IPR018957 55905 ring finger protein 114 [Source:HGNC Symbol;Acc:HGNC:13094] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Jussi Taipale Matt Weirauch No None $#ENSP00000244061#ENSG00000124226#ENST00000244061#Other#Prok-RING_4, U-box, zf-C3HC4, zf-C3HC4_2, zf-C3HC4$#ENSP00000485239#ENSG00000124226#ENST00000625177#Other#Prok-RING_4, U-box, zf-C3HC4, zf-C3HC4_2, zf-C3HC4$#ENSP00000485317#ENSG00000124226#ENST00000622920#Other#Prok-RING_4, U-box, zf-C3HC4, zf-C3HC4_2, zf-C3HC4 FALSE 2472 ENSG00000101695 RNF125 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Protein is a ubiguitin ligase IPR001841;IPR008598;IPR017907; 54941 ring finger protein 125 [Source:HGNC Symbol;Acc:HGNC:21150] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Jussi Taipale Arttu Jolma No None $#ENSP00000217740#ENSG00000101695#ENST00000217740#Other#Prok-RING_4, U-box, zf-C3HC4, zf-C3HC4_2, zf-C3HC4 FALSE 2473 ENSG00000134758 RNF138 Unknown No ssDNA/RNA binding Not a DNA binding protein No motif None DNA repair protein. RNF138 is recruited to DNA damage sites through zinc fingers that have a strong preference for DNA with 5- or 3-single-stranded overhangs. (PMID: 26502055) IPR001841;IPR004181;IPR008598;IPR018957 51444 ring finger protein 138 [Source:HGNC Symbol;Acc:HGNC:17765] None not tested Yes None None x No No No 5a, one of the source datasets predicts is as a TF Yimeng Yin Sam Lambert No None $#ENSP00000261593#ENSG00000134758#ENST00000261593#Other#Prok-RING_4, zf-C3HC4, zf-C3HC4_2, zf-C3HC4_3, zf-$#ENSP00000257190#ENSG00000134758#ENST00000257190#Other#zf-C2H2_4, zf-C3HC4, zf-C3HC4_2, zf-Di19, zf-MIZ, $#ENSP00000463659#ENSG00000134758#ENST00000577999#Other#zf-Di19$#ENSP00000462498#ENSG00000134758#ENST00000578107#Other#Prok-RING_4, U-box, zf-C3HC4, zf-C3HC4_2, zf-C3HC4$#ENSP00000463153#ENSG00000134758#ENST00000580499#Other#Prok-RING_4, zf-C3HC4, zf-C3HC4_2, zf-C3HC4_3, zf- FALSE 2474 ENSG00000013561 RNF14 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Transcriptional cofactor IPR001841;IPR002867;IPR006575;IPR016135;IPR017907 9604 ring finger protein 14 [Source:HGNC Symbol;Acc:HGNC:10058] None not tested not tested None None No No TF Gene_Transcription Factor Binding: tf co-factor binding_Co-activation; TF PPI_PMIDS:10085091 No 5a, one of the source datasets predicts is as a TF Laura Campitelli Arttu Jolma No None $##ENSG00000013561##Other# FALSE 2475 ENSG00000158717 RNF166 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Protein is a ubiquitin ligase (PMID: 26456228) IPR001841;IPR008598;IPR017907; 115992 ring finger protein 166 [Source:HGNC Symbol;Acc:HGNC:28856] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Arttu Jolma Sam Lambert No None $#ENSP00000326095#ENSG00000158717#ENST00000312838#Other#Prok-RING_4, Rubredoxin, U-box, UIM, zf-C3HC4, zf-$#ENSP00000446301#ENSG00000158717#ENST00000537718#Other#UIM, zf-Di19, zinc_ribbon_2$#ENSP00000440454#ENSG00000158717#ENST00000541206#Other#UIM, zf-Di19, zinc_ribbon_2$#ENSP00000455617#ENSG00000158717#ENST00000567408#Other#$#ENSP00000457374#ENSG00000158717#ENST00000568683#Other#zf-Di19, zf-ribbon_3, zinc_ribbon_2 FALSE 2476 ENSG00000121481 RNF2 Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None Forms non-specific DNA contacts according to crystal structure (PMID: 25355358) IPR001841;IPR017907;IPR018957 6045 ring finger protein 2 [Source:HGNC Symbol;Acc:HGNC:10061];E3 ubiquitin-protein ligase RING2 4R8P not tested not tested None None No No TF Gene_Transcription Factor Binding: tf co-factor binding_Co-activation_PMIDS:12183370;16687444 Yes 3a, decent circumstantial evidence for its role as Sam Lambert Jussi Taipale No $#ENSG00000121481#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#IMP - PMID:18629613 $#ENSP00000356480#ENSG00000121481#ENST00000367510#Other#RAWUL, zf-C3HC4, zf-C3HC4_2, zf-C3HC4_3, zf-C3HC4_$#ENSP00000356479#ENSG00000121481#ENST00000367509#Other#RAWUL, zf-C3HC4, zf-C3HC4_2, zf-C3HC4_3, zf-C3HC4_$#ENSP00000400722#ENSG00000121481#ENST00000453650#Other#zf-C3HC4, zf-C3HC4_2, zf-C3HC4_3, zf-C3HC4_4, zf-N FALSE 2477 ENSG00000163481 RNF25 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Probably a co-regulator; no clear evidence for direct binding to DNA IPR001841;IPR006575;IPR016135 64320 ring finger protein 25 [Source:HGNC Symbol;Acc:HGNC:14662];E3 ubiquitin-protein ligase RNF25 None not tested not tested None None No No TF Gene Candidate__Co-activation_PMIDS:12748188 Yes 4a, two or more datasets predict it as a TF Sam Lambert Arttu Jolma No $#ENSG00000163481#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IDA - PMID:12748188 $#ENSP00000295704#ENSG00000163481#ENST00000295704#Other#RWD, zf-RING_11, zf-RING_2 FALSE 2478 ENSG00000092098 RNF31 Unknown No ssDNA/RNA binding Not a DNA binding protein No motif None None IPR000315;IPR001876;IPR002867;IPR015940;IPR017907;IPR018997 55072 ring finger protein 31 [Source:HGNC Symbol;Acc:HGNC:16031];E3 ubiquitin-protein ligase RNF31 None Full not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Jussi Taipale Pratyush Das No $#ENSG00000092098#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IDA - PMID:19136968 $#ENSP00000315112#ENSG00000092098#ENST00000324103#Other#HOIP-UBA, IBR, PUB, zf-RanBP$#ENSP00000453574#ENSG00000092098#ENST00000559275#Other#HOIP-UBA, IBR, NMD3, zf-RanBP$#ENSP00000452972#ENSG00000092098#ENST00000560787#Other#HOIP-UBA, IBR, PUB, zf-RanBP$#ENSP00000452820#ENSG00000092098#ENST00000559719#Other#IBR$#ENSP00000453501#ENSG00000092098#ENST00000560754#Other#IBR FALSE 2479 ENSG00000063978 RNF4 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Protein is a ubiquitin ligase (PMID: 18408734) IPR001841;IPR017907 6047 ring finger protein 4 [Source:HGNC Symbol;Acc:HGNC:10067] None not tested not tested None None No No TF Gene Candidate__Co-activation_PMIDS:9710597 Yes 4a, two or more datasets predict it as a TF Matt Weirauch Arttu Jolma No $#ENSG00000063978#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:9710597 $#ENSP00000315212#ENSG00000063978#ENST00000314289#Other#Prok-RING_4, Rtf2, Zn_ribbon_17, zf-C3HC4, zf-C3HC$#ENSP00000424076#ENSG00000063978#ENST00000506706#Other#Prok-RING_4, Rtf2, Zn_ribbon_17, zf-C3HC4, zf-C3HC$#ENSP00000422728#ENSG00000063978#ENST00000507247#Other#$#ENSP00000422500#ENSG00000063978#ENST00000509258#Other#$#ENSP00000426615#ENSG00000063978#ENST00000511859#Other#$#ENSP00000446369#ENSG00000063978#ENST00000541204#Other#$#ENSP00000423100#ENSG00000063978#ENST00000502316#Other#Prok-RING_4, Rtf2, Zn_ribbon_17, zf-C3HC4, zf-C3HC$#ENSP00000426503#ENSG00000063978#ENST00000511600#Other#Prok-RING_4, Rtf2, Zn_ribbon_17, zf-C3HC4, zf-C3HC FALSE 2480 ENSG00000181852 RNF41 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Protein is a ubiquitin ligase None 10193 E3 ubiquitin-protein ligase NRDP1 None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Yimeng Yin Arttu Jolma No $#ENSG00000181852#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019 $##ENSG00000181852##Other# FALSE 2481 ENSG00000117748 RPA2 Unknown No ssDNA/RNA binding Not a DNA binding protein No motif None None IPR004365;IPR012340;IPR014646;IPR014892 6118 replication protein A2 [Source:HGNC Symbol;Acc:HGNC:10290] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Jussi Taipale Matt Weirauch No None $#ENSP00000363015#ENSG00000117748#ENST00000313433#Other#RPA_C, tRNA_anti-codon$#ENSP00000363021#ENSG00000117748#ENST00000373912#Other#RPA_C, tRNA_anti-codon$#ENSP00000363017#ENSG00000117748#ENST00000373909#Other#RPA_C, tRNA_anti-codon$#ENSP00000413541#ENSG00000117748#ENST00000419958#Other#RPA_C FALSE 2482 ENSG00000204086 RPA4 Unknown No ssDNA/RNA binding Not a DNA binding protein No motif None ssDNA binding protein involved in DNA repair (PMID: 7760808) IPR004365;IPR012340;IPR014646;IPR014892 29935 replication protein A4 [Source:HGNC Symbol;Acc:HGNC:30305] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Jussi Taipale Sam Lambert No None $#ENSP00000362131#ENSG00000204086#ENST00000373040#Other#RPA_C, tRNA_anti-codon FALSE 2483 ENSG00000147604 RPL7 Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None Binds DNA by filter binding (PMID: 8441630), but competition assays suggest it is non-specific. A specific dsRNA structure is thought to be the preferred substrate. RNA-binding has been demonstrated by gel-shift experiments (PMID: 10329420). IPR005998;IPR012988;IPR016082;IPR018038 6129 ribosomal protein L7 [Source:HGNC Symbol;Acc:HGNC:10363] None not tested not tested None None No No TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:7568167 No 5a, one of the source datasets predicts is as a TF Sam Lambert Laura Campitelli No None $##ENSG00000147604##Other# FALSE 2484 ENSG00000148303 RPL7A Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR001921;IPR004037;IPR004038;IPR018492;IPR029064 6130 ribosomal protein L7a [Source:HGNC Symbol;Acc:HGNC:10364] None not tested not tested None None No No TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:7568167 No 5a, one of the source datasets predicts is as a TF Jussi Taipale Laura Campitelli No None $##ENSG00000148303##Other# FALSE 2485 ENSG00000143947 RPS27A Unknown No ssDNA/RNA binding Not a DNA binding protein No motif None None IPR000626;IPR002906;IPR011332;IPR019954;IPR019956;IPR029071 6233 ribosomal protein S27a [Source:HGNC Symbol;Acc:HGNC:10417] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Jussi Taipale Pratyush Das No $#ENSG00000143947#GO:0051092#positive regulation of NF-kappaB transcription factor activity#TAS - Reactome:R-HSA-445989 $#ENSP00000272317#ENSG00000143947#ENST00000272317#Other#DUF2407, Rad60-SLD, Rad60-SLD_2, Ribosomal_S27, Ub$#ENSP00000385659#ENSG00000143947#ENST00000404735#Other#DUF2407, Rad60-SLD, Rad60-SLD_2, Ribosomal_S27, Ub$#ENSP00000383981#ENSG00000143947#ENST00000402285#Other#DUF2407, Rad60-SLD, Rad60-SLD_2, Ribosomal_S27, Ub$#ENSP00000408482#ENSG00000143947#ENST00000449323#Other#DUF2407, Rad60-SLD, Rad60-SLD_2, Ubiquitin_2, ubiq FALSE 2486 ENSG00000162302 RPS6KA4 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000719;IPR000961;IPR002290;IPR008271;IPR011009;IPR016239;IPR017441;IPR017892 8986 ribosomal protein S6 kinase A4 [Source:HGNC Symbol;Acc:HGNC:10433] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Pratyush Das Yimeng Yin No $#ENSG00000162302#GO:0032793#positive regulation of CREB transcription factor activity#TAS - PMID:18508628$#ENSG00000162302#GO:0051092#positive regulation of NF-kappaB transcription factor activity#TAS - PMID:18508628 $#ENSP00000333896#ENSG00000162302#ENST00000334205#Other#APH, FTA2, Kdo, Kinase-like, Pkinase, Pkinase_C, P$#ENSP00000435580#ENSG00000162302#ENST00000528057#Other#APH, FTA2, Kdo, Kinase-like, Pkinase, Pkinase_C, P$#ENSP00000432945#ENSG00000162302#ENST00000530504#Other#APH, FTA2, Kdo, Kinase-like, Pkinase, Pkinase_C, P FALSE 2487 ENSG00000100784 RPS6KA5 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None No DBD - its a kinase. Included only because GO says its an upstream regulator of CREB and NF-kappaB IPR000719;IPR000961;IPR002290;IPR008271;IPR011009;IPR016239;IPR017441;IPR017892 9252 ribosomal protein S6 kinase A5 [Source:HGNC Symbol;Acc:HGNC:10434] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Arttu Jolma Tim Hughes No $#ENSG00000100784#GO:0032793#positive regulation of CREB transcription factor activity#TAS - PMID:18508628$#ENSG00000100784#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IMP - PMID:12628924, PMID:18511904 $#ENSP00000402787#ENSG00000100784#ENST00000418736#Other#APH, FTA2, Kdo, Kinase-like, Pkinase, Pkinase_C, P$#ENSP00000479667#ENSG00000100784#ENST00000614987#Other#APH, Choline_kinase, FTA2, Kdo, Kinase-like, Pkina$#ENSP00000442803#ENSG00000100784#ENST00000536315#Other#APH, Choline_kinase, FTA2, Kdo, Kinase-like, Pkina FALSE 2488 ENSG00000085721 RRN3 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR007991 54700 RRN3 homolog, RNA polymerase I transcription factor [Source:HGNC Symbol;Acc:HGNC:30346] None not tested not tested None None No No TF Gene_Transcription Factor Binding: tf co-factor binding_Co-activation_PMIDS:8670901;10758157;11250903 No 5a, one of the source datasets predicts is as a TF Matt Weirauch Jussi Taipale No None $##ENSG00000085721##Other# FALSE 2489 ENSG00000079102 RUNX1T1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR002893;IPR003894;IPR013289;IPR013290;IPR014896 862 RUNX1 translocation partner 1 [Source:HGNC Symbol;Acc:HGNC:1535] None not tested not tested None None No No TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:9724795;9819404 Yes 4a, two or more datasets predict it as a TF Matt Weirauch Pratyush Das No $#ENSG00000079102#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002 $#ENSP00000353504#ENSG00000079102#ENST00000360348#Other#NHR2, TAFH, zf-MYND$#ENSP00000379520#ENSG00000079102#ENST00000396218#Other#NHR2, TAFH, zf-MYND$#ENSP00000390137#ENSG00000079102#ENST00000422361#Other#NHR2, TAFH, zf-MYND$#ENSP00000430728#ENSG00000079102#ENST00000518844#Other#NHR2, TAFH, zf-MYND$#ENSP00000429728#ENSG00000079102#ENST00000521553#Other#TAFH$#ENSP00000428742#ENSG00000079102#ENST00000520724#Other#DUF3731, NHR2, TAFH, zf-MYND$#ENSP00000429666#ENSG00000079102#ENST00000521375#Other# FALSE 2490 ENSG00000122481 RWDD3 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Included because GO says negative regulation of NF-kappaB transcription factor activity. No DBD, no motif, etc IPR006575;IPR016135 25950 RWD domain containing 3 [Source:HGNC Symbol;Acc:HGNC:21393] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Tim Hughes Laura Campitelli No $#ENSG00000122481#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IDA - PMID:23469069 $#ENSP00000263893#ENSG00000122481#ENST00000263893#Other#RWD$#ENSP00000359221#ENSG00000122481#ENST00000370202#Other#DUF1115, RWD FALSE 2491 ENSG00000163602 RYBP Unknown No ssDNA/RNA binding Not a DNA binding protein No motif None Contains RanBP ZFs, so likely an RNA-binding protein IPR001876 23429 RING1 and YY1 binding protein None not tested not tested None None No No TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI; Transactivation_PMIDS:10369680;12411495 No 5a, one of the source datasets predicts is as a TF Laura Campitelli Matt Weirauch No None $##ENSG00000163602##Other# FALSE 2492 ENSG00000163221 S100A12 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR001751;IPR002048;IPR013787 6283 S100 calcium binding protein A12 [Source:HGNC Symbol;Acc:HGNC:10489] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Laura Campitelli Matt Weirauch No $#ENSG00000163221#GO:0051092#positive regulation of NF-kappaB transcription factor activity#TAS - PMID:18443896 $#ENSP00000357726#ENSG00000163221#ENST00000368737#Other#EF-hand_1, EF-hand_6, EF-hand_7, EF-hand_8, S_100 FALSE 2493 ENSG00000143546 S100A8 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR001751;IPR002048;IPR013787;IPR018247 6279 S100 calcium binding protein A8 [Source:HGNC Symbol;Acc:HGNC:10498] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Matt Weirauch Jussi Taipale No $#ENSG00000143546#GO:0051092#positive regulation of NF-kappaB transcription factor activity#TAS - PMID:22489132 $#ENSP00000357722#ENSG00000143546#ENST00000368733#Other#EF-hand_1, EF-hand_5, EF-hand_7, EF-hand_8, S_100$#ENSP00000357721#ENSG00000143546#ENST00000368732#Other#EF-hand_1, EF-hand_5, EF-hand_7, EF-hand_8, S_100 FALSE 2494 ENSG00000163220 S100A9 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR001751;IPR002048;IPR013787;IPR018247 6280 S100 calcium binding protein A9 [Source:HGNC Symbol;Acc:HGNC:10499] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Laura Campitelli Pratyush Das No $#ENSG00000163220#GO:0051092#positive regulation of NF-kappaB transcription factor activity#TAS - PMID:22489132 $#ENSP00000357727#ENSG00000163220#ENST00000368738#Other#EF-hand_1, EF-hand_4, EF-hand_7, EF-hand_8, S_100 FALSE 2495 ENSG00000160633 SAFB Unknown Yes Likely to be sequence specific TF Low specificity DNA-binding protein No motif None Based on this review the protein is likely to bind AT-rich DNA in a non-sequence specific manner (PMID: 27888239) IPR000504;IPR003034 6294 scaffold attachment factor B [Source:HGNC Symbol;Acc:HGNC:10520] None not tested not tested None None No No TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:15066997 No 5a, one of the source datasets predicts is as a TF Pratyush Das Arttu Jolma No None $##ENSG00000160633##Other# FALSE 2496 ENSG00000130254 SAFB2 Unknown Yes Likely to be sequence specific TF Low specificity DNA-binding protein No motif None Bind AT-rich DNA elements and RNA (PMID: 27888239) IPR000504;IPR003034 9667 scaffold attachment factor B2 [Source:HGNC Symbol;Acc:HGNC:21605] None not tested not tested None None No No TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_Co-activation; TF PPI_PMIDS:12660241 No 5a, one of the source datasets predicts is as a TF Arttu Jolma Sam Lambert No None $##ENSG00000130254##Other# FALSE 2497 ENSG00000151748 SAV1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None None 60485 Protein salvador homolog 1 None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Sam Lambert Matt Weirauch No $#ENSG00000151748#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019 $##ENSG00000151748##Other# FALSE 2498 ENSG00000171222 SCAND1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR003309;IPR008916 51282 SCAN domain containing 1 [Source:HGNC Symbol;Acc:HGNC:10566] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Matt Weirauch Laura Campitelli No $#ENSG00000171222#GO:0003700#sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024 $#ENSP00000301995#ENSG00000171222#ENST00000305978#Other#SCAN$#ENSP00000363103#ENSG00000171222#ENST00000373991#Other#SCAN$#ENSP00000481289#ENSG00000171222#ENST00000615116#Other#SCAN FALSE 2499 ENSG00000176700 SCAND2P Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif Pseudogene None None Has no Entrez identifier Putative SCAN domain-containing protein SCAND2P None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Pratyush Das Sam Lambert No $#ENSG00000176700#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $##ENSG00000176700##Other# FALSE 2500 ENSG00000140386 SCAPER Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Involved in cell cycle regulation in the cytoplasm (PMID: 17698606) IPR003604; 49855 S-phase cyclin A associated protein in the ER [Source:HGNC Symbol;Acc:HGNC:13081] None not tested not tested None None c No No No 5a, one of the source datasets predicts is as a TF Laura Campitelli Arttu Jolma No None $#ENSP00000326924#ENSG00000140386#ENST00000324767#Other#SCAPER_N, zf-met$#ENSP00000442190#ENSG00000140386#ENST00000538941#Other#zf-met$#ENSP00000456508#ENSG00000140386#ENST00000564590#Other#SCAPER_N$#ENSP00000456987#ENSG00000140386#ENST00000564022#Other# FALSE 2501 ENSG00000010803 SCMH1 Unknown Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Has a SLED domain (IPR021987). (PMID: 24727478) claims, based on NMR, that SLED is a sequence-specific DBD with relatively high specificity IPR001660;IPR004092;IPR013761;IPR021129;IPR021987 22955 sex comb on midleg homolog 1 (Drosophila) [Source:HGNC Symbol;Acc:HGNC:19003];Polycomb protein SCMH1 None not tested not tested None None No No TF Gene Candidate__Other_PMIDS:10653359 Yes 4a, two or more datasets predict it as a TF Tim Hughes Jussi Taipale No $#ENSG00000010803#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:10524249 $#ENSP00000318094#ENSG00000010803#ENST00000326197#Other#MBT, RBR, SAM_1, SAM_2, SAM_PNT, SLED$#ENSP00000354656#ENSG00000010803#ENST00000361191#Other#MBT, RBR, SAM_1, SAM_2, SAM_PNT, SLED$#ENSP00000354996#ENSG00000010803#ENST00000361705#Other#MBT, RBR, SAM_1, SAM_2, SAM_PNT, SLED$#ENSP00000361676#ENSG00000010803#ENST00000372595#Other#MBT, RBR, SAM_1, SAM_2, SAM_PNT, SLED$#ENSP00000361677#ENSG00000010803#ENST00000372596#Other#MBT, RBR, SAM_1, SAM_2, SAM_PNT, SLED$#ENSP00000361678#ENSG00000010803#ENST00000372597#Other#MBT, RBR, SAM_1, SAM_2, SAM_PNT, SLED$#ENSP00000380356#ENSG00000010803#ENST00000397171#Other#MBT, RBR, SAM_1, SAM_2, SAM_PNT, SLED$#ENSP00000337352#ENSG00000010803#ENST00000337495#Other#MBT, RBR, SAM_1, SAM_2, SAM_PNT, SLED$#ENSP00000380359#ENSG00000010803#ENST00000397174#Other#MBT, RBR, SAM_1, SAM_2, SAM_PNT, SLED$#ENSP00000403974#ENSG00000010803#ENST00000456518#Other#MBT, RBR, SAM_1, SAM_2, SAM_PNT, SLED$#ENSP00000479881#ENSG00000010803#ENST00000472037#Other#SAM_1, SAM_2, SAM_PNT FALSE 2502 ENSG00000047634 SCML1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Homologous to polycomb proteins, so likely a transcriptional cofactor (PMID: 9570953). Has putative roles in the testis development and spermatogenesis (PMID:18601738). Reference cited by GO provides no evidence of DNA-binding activity (PMID: 9570953). IPR001660;IPR013761;IPR021129 6322 sex comb on midleg-like 1 (Drosophila) [Source:HGNC Symbol;Acc:HGNC:10580] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Arttu Jolma Sam Lambert No $#ENSG00000047634#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:9570953 $#ENSP00000369382#ENSG00000047634#ENST00000380043#Other#SAM_1, SAM_2, SAM_PNT$#ENSP00000369384#ENSG00000047634#ENST00000380045#Other#SAM_1, SAM_2, SAM_PNT$#ENSP00000381154#ENSG00000047634#ENST00000398080#Other#SAM_1, SAM_2, SAM_PNT$#ENSP00000392587#ENSG00000047634#ENST00000419185#Other# FALSE 2503 ENSG00000102098 SCML2 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Part of the polycomb repressor complex that functions in male, establishing the male germline epigenome through regulation of histone H2A ubiquitination (PMID: 25703348) IPR001660;IPR004092;IPR013761;IPR021129;IPR021987 10389 sex comb on midleg-like 2 (Drosophila) [Source:HGNC Symbol;Acc:HGNC:10581] None not tested not tested None None No No TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_Other_PMIDS:12952983;15280237 Yes 4a, two or more datasets predict it as a TF Arttu Jolma Yimeng Yin No $#ENSG00000102098#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:10331946 $#ENSP00000251900#ENSG00000102098#ENST00000251900#Other#MBT, RBR, SAM_1, SAM_PNT, SLED$#ENSP00000381126#ENSG00000102098#ENST00000398048#Other#SAM_1, SAM_2, SAM_PNT$#ENSP00000407315#ENSG00000102098#ENST00000420857#Other# FALSE 2504 ENSG00000196189 SEMA4A Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR001627;IPR002165;IPR016201; 64218 semaphorin 4A [Source:HGNC Symbol;Acc:HGNC:10729] None not tested Yes None None x No No No 5a, one of the source datasets predicts is as a TF Pratyush Das Sam Lambert No None $#ENSP00000347117#ENSG00000196189#ENST00000355014#Other#PSI, Sema$#ENSP00000357265#ENSG00000196189#ENST00000368282#Other#PSI, Sema$#ENSP00000357268#ENSG00000196189#ENST00000368285#Other#PSI, Sema$#ENSP00000357267#ENSG00000196189#ENST00000368284#Other#PSI, Sema FALSE 2505 ENSG00000197019 SERTAD1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Transcriptional co-factor; no evidence for DNA-binding activity IPR009263 29950 SERTA domain containing 1 [Source:HGNC Symbol;Acc:HGNC:17932] None not tested not tested None None No No TF Gene_Transcription Factor Binding: tf co-factor binding_Co-activation; Transactivation_PMIDS:11331592;16098148 No 5a, one of the source datasets predicts is as a TF Sam Lambert Pratyush Das No None $##ENSG00000197019##Other# FALSE 2506 ENSG00000179833 SERTAD2 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Transcriptional cofactor that associates with E2F/TFDP heterodimers (PMID: 19152710). Does not contain any DBDs IPR009263 9792 SERTA domain containing 2 [Source:HGNC Symbol;Acc:HGNC:30784] None not tested not tested None None No No TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:16098148 No 5a, one of the source datasets predicts is as a TF Arttu Jolma Pratyush Das No None $##ENSG00000179833##Other# FALSE 2507 ENSG00000103037 SETD6 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Methyltransferase to the NF-kappaB complex (PMID: 21131967) and histones (PMID: 23324626) IPR001214;IPR011383;IPR015353 79918 SET domain containing 6 [Source:HGNC Symbol;Acc:HGNC:26116];N-lysine methyltransferase SETD6 None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Arttu Jolma Laura Campitelli No $#ENSG00000103037#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IMP - PMID:21131967 $#ENSP00000219315#ENSG00000103037#ENST00000219315#Other#Rubis-subs-bind, SET$#ENSP00000310082#ENSG00000103037#ENST00000310682#Other#Rubis-subs-bind, SET$#ENSP00000377809#ENSG00000103037#ENST00000394266#Other#Rubis-subs-bind, SET$#ENSP00000396437#ENSG00000103037#ENST00000447443#Other#Rubis-subs-bind FALSE 2508 ENSG00000104897 SF3A2 Unknown No ssDNA/RNA binding Not a DNA binding protein No motif None Functions in splicing IPR000690;IPR003604;IPR019134; 8175 splicing factor 3a subunit 2 [Source:HGNC Symbol;Acc:HGNC:10766] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Arttu Jolma Matt Weirauch No None $#ENSP00000221494#ENSG00000104897#ENST00000221494#Other#CactinC_cactus, SF3A2, zf-met$#ENSP00000466634#ENSG00000104897#ENST00000586396#Other#SF3A2, zf-met FALSE 2509 ENSG00000183431 SF3A3 Unknown No ssDNA/RNA binding Not a DNA binding protein No motif None RNA-binding protein IPR000690;IPR021966;IPR024598; 10946 splicing factor 3a subunit 3 [Source:HGNC Symbol;Acc:HGNC:10767] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Sam Lambert Pratyush Das No None $#ENSP00000362110#ENSG00000183431#ENST00000373019#Other#DUF3449, SF3A3, SF3a60_bindingd, Telomere_Sde2_2 FALSE 2510 ENSG00000116560 SFPQ Unknown No ssDNA/RNA binding Not a DNA binding protein No motif None Splicing factor - contains 2 RRM domains None 6421 splicing factor proline and glutamine rich [Source:HGNC Symbol;Acc:HGNC:10774] None not tested not tested None None No No No No 2a1, Lower confidence direct evidence Yimeng Yin Sam Lambert Yes None $##ENSG00000116560##Other# FALSE 2511 ENSG00000106483 SFRP4 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR001134;IPR008993;IPR018933;IPR020067 6424 secreted frizzled related protein 4 [Source:HGNC Symbol;Acc:HGNC:10778] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Jussi Taipale Sam Lambert No $#ENSG00000106483#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:18945944 $#ENSP00000410715#ENSG00000106483#ENST00000436072#Other#Fz, NTR$#ENSP00000402262#ENSG00000106483#ENST00000447200#Other#NTR FALSE 2512 ENSG00000120057 SFRP5 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR001134;IPR008993;IPR018933;IPR020067 6425 secreted frizzled related protein 5 [Source:HGNC Symbol;Acc:HGNC:10779] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Matt Weirauch Sam Lambert No $#ENSG00000120057#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#IMP - PMID:19957335 $#ENSP00000266066#ENSG00000120057#ENST00000266066#Other#Fz, NTR FALSE 2513 ENSG00000168878 SFTPB Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR003119;IPR007856;IPR008138;IPR008139;IPR008373;IPR011001 6439 surfactant protein B [Source:HGNC Symbol;Acc:HGNC:10801] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Sam Lambert Jussi Taipale No None $#ENSP00000428719#ENSG00000168878#ENST00000519937#Other#SapA, SapB_1, SapB_2$#ENSP00000415347#ENSG00000168878#ENST00000428225#Other#SapA, SapB_1, SapB_2$#ENSP00000476194#ENSG00000168878#ENST00000494165#Other#SapB_2 FALSE 2514 ENSG00000118515 SGK1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000719;IPR000961;IPR001683;IPR002290;IPR008271;IPR011009;IPR017441;IPR017892 6446 serum/glucocorticoid regulated kinase 1 [Source:HGNC Symbol;Acc:HGNC:10810] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Pratyush Das Yimeng Yin No $#ENSG00000118515#GO:0051090#regulation of sequence-specific DNA binding transcription factor activity#TAS - PMID:20530112 $#ENSP00000237305#ENSG00000118515#ENST00000237305#Other#FTA2, Kdo, Kinase-like, Pkinase, Pkinase_C, Pkinas$#ENSP00000356831#ENSG00000118515#ENST00000367857#Other#FTA2, Kdo, Kinase-like, PX, Pkinase, Pkinase_C, Pk$#ENSP00000356832#ENSG00000118515#ENST00000367858#Other#FTA2, Kdo, Kinase-like, PX, Pkinase, Pkinase_C, Pk$#ENSP00000396242#ENSG00000118515#ENST00000413996#Other#FTA2, Kdo, Kinase-like, Pkinase, Pkinase_C, Pkinas$#ENSP00000435724#ENSG00000118515#ENST00000524929#Other#$#ENSP00000434450#ENSG00000118515#ENST00000528577#Other#FTA2, Kdo, Kinase-like, Pkinase, Pkinase_C, Pkinas$#ENSP00000434302#ENSG00000118515#ENST00000475719#Other#FTA2, Kdo, Kinase-like, Pkinase, Pkinase_C, Pkinas$#ENSP00000431705#ENSG00000118515#ENST00000460769#Other# FALSE 2515 ENSG00000104205 SGK3 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Protein kinase that operates upstream in the signaling cascade IPR000719;IPR000961;IPR001683;IPR002290;IPR008271;IPR011009;IPR017441;IPR017892 23678 serum/glucocorticoid regulated kinase family member 3 [Source:HGNC Symbol;Acc:HGNC:10812] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Arttu Jolma Matt Weirauch No $#ENSG00000104205#GO:0051090#regulation of sequence-specific DNA binding transcription factor activity#TAS - PMID:20919962 $#ENSP00000331816#ENSG00000104205#ENST00000345714#Other#FTA2, Kinase-like, PX, Pkinase, Pkinase_C, Pkinase$#ENSP00000379842#ENSG00000104205#ENST00000396596#Other#FTA2, Kinase-like, PX, Pkinase, Pkinase_C, Pkinase$#ENSP00000430463#ENSG00000104205#ENST00000521198#Other#FTA2, Kinase-like, PX, Pkinase, Pkinase_C, Pkinase$#ENSP00000430691#ENSG00000104205#ENST00000520976#Other#FTA2, Kinase-like, PX, Pkinase, Pkinase_C, Pkinase$#ENSP00000428529#ENSG00000104205#ENST00000519396#Other#Pkinase, Pkinase_Tyr$#ENSP00000429565#ENSG00000104205#ENST00000521152#Other#PX, Pkinase, Pkinase_Tyr$#ENSP00000429606#ENSG00000104205#ENST00000522629#Other#PX FALSE 2516 ENSG00000164690 SHH Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000320;IPR001657;IPR001767;IPR003586;IPR003587;IPR006141;IPR009045;IPR028992 6469 sonic hedgehog [Source:HGNC Symbol;Acc:HGNC:10848] None not tested not tested None None No No Probably Not a TF - No evidence that it is a TF___PMIDS:0 Yes 3a, decent circumstantial evidence for its role as Yimeng Yin Pratyush Das No $#ENSG00000164690#GO:0007228#positive regulation of hh target transcription factor activity#ISS - GO_REF:0000024 $#ENSP00000297261#ENSG00000164690#ENST00000297261#Other#HH_signal, Hint, Peptidase_M15_3$#ENSP00000396621#ENSG00000164690#ENST00000430104#Other#HH_signal, Peptidase_M15_3 FALSE 2517 ENSG00000146414 SHPRH Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000330;IPR001650;IPR001841;IPR001965;IPR005818;IPR011011;IPR014001;IPR017907;IPR019786;IPR019787;IPR027417; 257218 SNF2 histone linker PHD RING helicase [Source:HGNC Symbol;Acc:HGNC:19336] None Full not tested None None x No No No 5a, one of the source datasets predicts is as a TF Yimeng Yin Matt Weirauch No None $#ENSP00000275233#ENSG00000146414#ENST00000275233#Other#Helicase_C, Linker_histone, PHD, SNF2_N, zf-C3HC4,$#ENSP00000412797#ENSG00000146414#ENST00000438092#Other#Helicase_C, Linker_histone, PHD, SNF2_N, zf-C3HC4,$#ENSP00000403790#ENSG00000146414#ENST00000417762#Other#Helicase_C FALSE 2518 ENSG00000185187 SIGIRR Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000157;IPR007110 59307 single immunoglobulin and toll-interleukin 1 receptor (TIR) domain [Source:HGNC Symbol;Acc:HGNC:3057 None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Laura Campitelli Jussi Taipale No $#ENSG00000185187#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#IMP - PMID:12925853 $#ENSP00000380756#ENSG00000185187#ENST00000397632#Other#Ig_2, Ig_3, TIR, TIR_2$#ENSP00000403104#ENSG00000185187#ENST00000431843#Other#Ig_2, Ig_3, TIR, TIR_2$#ENSP00000333656#ENSG00000185187#ENST00000332725#Other#Ig_2, Ig_3, TIR, TIR_2$#ENSP00000433530#ENSG00000185187#ENST00000526395#Other#$#ENSP00000434164#ENSG00000185187#ENST00000528845#Other#$#ENSP00000433022#ENSG00000185187#ENST00000531205#Other#Ig_2, Ig_3, TIR, TIR_2$#ENSP00000435135#ENSG00000185187#ENST00000528209#Other#TIR, TIR_2$#ENSP00000434030#ENSG00000185187#ENST00000530494#Other#Ig_2 FALSE 2519 ENSG00000142178 SIK1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000719;IPR002290;IPR008271;IPR011009;IPR015940;IPR017090;IPR017441 150094 salt inducible kinase 1 [Source:HGNC Symbol;Acc:HGNC:11142] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Jussi Taipale Sam Lambert No $#ENSG00000142178#GO:0032792#negative regulation of CREB transcription factor activity#ISS - GO_REF:0000024 $#ENSP00000270162#ENSG00000142178#ENST00000270162#Other#Kinase-like, Pkinase, Pkinase_Tyr FALSE 2520 ENSG00000169375 SIN3A Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif Only known motifs are from Transfac or HocoMoco - origin is uncertain Motifs are suspect and probably reflect DNA binding specificities of SIN3 contacted TFs. SIN3 does not have any DBDs and is thought to function as a scaffold protein that connects TFs to HDAC complexes. Reviewed in (PMID: 19505602) IPR003822;IPR013194 25942 SIN3 transcription regulator family member A [Source:HGNC Symbol;Acc:HGNC:19353] None not tested not tested None None No Yes TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:7889570;12091390 No 2a1, Lower confidence direct evidence Sam Lambert Arttu Jolma No $#ENSG00000169375#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019 $#ENSP00000353622#ENSG00000169375#ENST00000360439#Other#PAH, Sin3_corepress, Sin3a_C$#ENSP00000378402#ENSG00000169375#ENST00000394947#Other#PAH, Sin3_corepress, Sin3a_C$#ENSP00000378403#ENSG00000169375#ENST00000394949#Other#PAH, Sin3_corepress, Sin3a_C$#ENSP00000455204#ENSG00000169375#ENST00000564778#Other#PAH$#ENSP00000455834#ENSG00000169375#ENST00000567289#Other# FALSE 2521 ENSG00000127511 SIN3B Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Can be tethered to DNA by Mad-Max, but does not appear to have any specificity (PMID: 7889570) IPR003822;IPR013194 23309 SIN3 transcription regulator family member B [Source:HGNC Symbol;Acc:HGNC:19354] None not tested not tested None None No No TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:15935060 No 5a, one of the source datasets predicts is as a TF Sam Lambert Matt Weirauch No None $##ENSG00000127511##Other# FALSE 2522 ENSG00000096717 SIRT1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR003000;IPR026590;IPR029035 23411 sirtuin 1 [Source:HGNC Symbol;Acc:HGNC:14929];NAD-dependent protein deacetylase sirtuin-1 None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Matt Weirauch Sam Lambert No $#ENSG00000096717#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IDA - PMID:15152190$#ENSG00000096717#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:11672523, PMID:20955178 | IMP - PMID:17 $#ENSP00000212015#ENSG00000096717#ENST00000212015#Other#DUF592, SIR2, TPP_enzyme_M$#ENSP00000384063#ENSG00000096717#ENST00000403579#Other#SIR2$#ENSP00000384508#ENSG00000096717#ENST00000406900#Other#SIR2$#ENSP00000409208#ENSG00000096717#ENST00000432464#Other#SIR2 FALSE 2523 ENSG00000068903 SIRT2 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR003000;IPR017328;IPR026590;IPR029035 22933 sirtuin 2 [Source:HGNC Symbol;Acc:HGNC:10886] None not tested not tested None None No No Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0 No 5a, one of the source datasets predicts is as a TF Jussi Taipale Yimeng Yin No None $##ENSG00000068903##Other# FALSE 2524 ENSG00000142082 SIRT3 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Protein is a histone de-acetylase IPR003000;IPR017328;IPR026590;IPR029035 23410 sirtuin 3 [Source:HGNC Symbol;Acc:HGNC:14931] None not tested not tested None None No No TF Gene Candidate__Transactivation_PMIDS:15676284 No 5a, one of the source datasets predicts is as a TF Arttu Jolma Sam Lambert No None $##ENSG00000142082##Other# FALSE 2525 ENSG00000077463 SIRT6 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif Only known motifs are from Transfac or HocoMoco - origin is uncertain No canonical DBD, but it does bind at least one sequence-specific DNA binding protein (TRF2). Seems more likely to be a cofactor. IPR003000;IPR026590;IPR029035 51548 sirtuin 6 [Source:HGNC Symbol;Acc:HGNC:14934] None not tested not tested None None No Yes No No 2a1, Lower confidence direct evidence Tim Hughes Pratyush Das No None $#ENSP00000305310#ENSG00000077463#ENST00000305232#Other#SIR2, TPP_enzyme_M$#ENSP00000337332#ENSG00000077463#ENST00000337491#Other#SIR2, TPP_enzyme_M$#ENSP00000469001#ENSG00000077463#ENST00000601488#Other#SIR2$#ENSP00000471837#ENSG00000077463#ENST00000601571#Other#SIR2$#ENSP00000472023#ENSG00000077463#ENST00000594279#Other#SIR2$#ENSP00000470215#ENSG00000077463#ENST00000597896#Other#SIR2, TPP_enzyme_M FALSE 2526 ENSG00000184990 SIVA1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Affects transcription through interactions with NF-kappaB (PMID: 16491128) IPR006058;IPR022773 10572 SIVA1 apoptosis inducing factor [Source:HGNC Symbol;Acc:HGNC:17712];Apoptosis regulatory protein Siv None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Pratyush Das Laura Campitelli No None $#ENSP00000329213#ENSG00000184990#ENST00000329967#Other#Siva$#ENSP00000329447#ENSG00000184990#ENST00000347067#Other#Siva$#ENSP00000485991#ENSG00000184990#ENST00000535554#Other#Siva$#ENSP00000451570#ENSG00000184990#ENST00000553810#Other#Siva$#ENSP00000451823#ENSG00000184990#ENST00000556195#Other#Siva FALSE 2527 ENSG00000157933 SKI Unknown Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Conflicting evidence. Binds specifically to GTCTAGAC via EMSA in one study (PMID: 9452486). But, needs to form complexes with other proteins, such as NFI, to bind to DNA in another (PMID: 9380514). Related to SKIL, which also has evidence for DNA binding (PMID: 9824161) IPR003380;IPR009061;IPR010919;IPR014890 6497 SKI proto-oncogene [Source:HGNC Symbol;Acc:HGNC:10896] None DBD not tested None None a No TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:12435627 Yes 4a, two or more datasets predict it as a TF Yimeng Yin Jussi Taipale No $#ENSG00000157933#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IBA - GO_REF:0000033 $#ENSP00000367797#ENSG00000157933#ENST00000378536#Other#Ski_Sno, c-SKI_SMAD_bind FALSE 2528 ENSG00000180592 SKIDA1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR003380;IPR009061;IPR027971; 387640 SKI/DACH domain containing 1 [Source:HGNC Symbol;Acc:HGNC:32697] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Sam Lambert Pratyush Das No None $#ENSP00000410041#ENSG00000180592#ENST00000449193#Other#DUF4584, Ski_Sno$#ENSP00000442432#ENSG00000180592#ENST00000444772#Other#DUF4584, Ski_Sno FALSE 2529 ENSG00000136603 SKIL Unknown Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Homodimerizes on GTCTAGAC sequence (EMSA) (PMID: 9824161) IPR003380;IPR009061;IPR010919;IPR014890 6498 SKI-like proto-oncogene [Source:HGNC Symbol;Acc:HGNC:10897] None DBD and Full not tested None None a No TF Gene_Transcription Factor Binding: tf co-factor binding_DNA Binding; Transactivation_PMIDS:9824161;9927733;10531062 Yes 4a, two or more datasets predict it as a TF Laura Campitelli Yimeng Yin No $#ENSG00000136603#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:10531062 $#ENSP00000259119#ENSG00000136603#ENST00000259119#Other#Ski_Sno, c-SKI_SMAD_bind$#ENSP00000400193#ENSG00000136603#ENST00000413427#Other#Ski_Sno, c-SKI_SMAD_bind$#ENSP00000415243#ENSG00000136603#ENST00000458537#Other#Ski_Sno, c-SKI_SMAD_bind$#ENSP00000406520#ENSG00000136603#ENST00000426052#Other#Ski_Sno, c-SKI_SMAD_bind FALSE 2530 ENSG00000188779 SKOR1 Unknown Yes Known motif Monomer or homomultimer High-throughput in vitro None None IPR003380;IPR009061;IPR010919;IPR014890 390598 SKI family transcriptional corepressor 1 [Source:HGNC Symbol;Acc:HGNC:21326] None DBD not tested None None a No No Yes 1a1, Direct HQ evidence Pratyush Das Arttu Jolma No $#ENSG00000188779#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IBA - GO_REF:0000033 $#ENSP00000343200#ENSG00000188779#ENST00000341418#Other#Ski_Sno, c-SKI_SMAD_bind$#ENSP00000369374#ENSG00000188779#ENST00000380035#Other#Ski_Sno, c-SKI_SMAD_bind$#ENSP00000452361#ENSG00000188779#ENST00000554054#Other#Ski_Sno, c-SKI_SMAD_bind$#ENSP00000451193#ENSG00000188779#ENST00000554240#Other#Ski_Sno, c-SKI_SMAD_bind FALSE 2531 ENSG00000197208 SLC22A4 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Protein is a transmembrane protein of the plasmamembrane IPR004749;IPR005828;IPR005829;IPR020846 6583 solute carrier family 22 member 4 [Source:HGNC Symbol;Acc:HGNC:10968] None Full not tested None None x No No No 5a, one of the source datasets predicts is as a TF Sam Lambert Arttu Jolma No None $#ENSP00000200652#ENSG00000197208#ENST00000200652#Other#MFS_1, Sugar_tr FALSE 2532 ENSG00000135502 SLC26A10 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR002645;IPR011547;IPR030402; 65012 solute carrier family 26 member 10 [Source:HGNC Symbol;Acc:HGNC:14470] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Matt Weirauch Sam Lambert No None $#ENSP00000320217#ENSG00000135502#ENST00000320442#Other#STAS, Sulfate_transp$#ENSP00000490604#ENSG00000135502#ENST00000637859#Other#Sulfate_transp FALSE 2533 ENSG00000091138 SLC26A3 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Included as a candidate only because GO cites a 1993 paper where sequence analysis identified a homeodomain. But, there seems to be no homeodomain. IPR001902;IPR002645;IPR011547;IPR018045;IPR030402 1811 solute carrier family 26 member 3 [Source:HGNC Symbol;Acc:HGNC:3018];Chloride anion exchanger None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Tim Hughes Matt Weirauch No $#ENSG00000091138#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:7683425 $#ENSP00000345873#ENSG00000091138#ENST00000340010#Other#STAS, Sulfate_transp$#ENSP00000395955#ENSG00000091138#ENST00000453332#Other#Sulfate_transp FALSE 2534 ENSG00000014824 SLC30A9 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR002524;IPR009061 10463 solute carrier family 30 member 9 [Source:HGNC Symbol;Acc:HGNC:1329] None not tested not tested None None c No No Yes 4a, two or more datasets predict it as a TF Pratyush Das Laura Campitelli No $#ENSG00000014824#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:10409434 $#ENSP00000264451#ENSG00000014824#ENST00000264451#Other#Cation_efflux, XPA_C FALSE 2535 ENSG00000196950 SLC39A10 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR003689; 57181 solute carrier family 39 member 10 [Source:HGNC Symbol;Acc:HGNC:20861] None Full not tested None None x No No No 5a, one of the source datasets predicts is as a TF Jussi Taipale Sam Lambert No None $#ENSP00000352655#ENSG00000196950#ENST00000359634#Other#Zip$#ENSP00000386766#ENSG00000196950#ENST00000409086#Other#Zip$#ENSP00000406590#ENSG00000196950#ENST00000412905#Other# FALSE 2536 ENSG00000144290 SLC4A10 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR003020;IPR003024;IPR011531;IPR013769;IPR016152; 57282 solute carrier family 4 member 10 [Source:HGNC Symbol;Acc:HGNC:13811] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Matt Weirauch Laura Campitelli No None $#ENSP00000395797#ENSG00000144290#ENST00000415876#Other#Band_3_cyto, HCO3_cotransp$#ENSP00000393066#ENSG00000144290#ENST00000446997#Other#Band_3_cyto, HCO3_cotransp$#ENSP00000364664#ENSG00000144290#ENST00000375514#Other#Band_3_cyto, HCO3_cotransp FALSE 2537 ENSG00000080503 SMARCA2 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif Has a putative AT-hook No clear DBD, and its a known cofactor IPR000330;IPR001487;IPR001650;IPR006576;IPR013999;IPR014001;IPR014012;IPR014978;IPR018359;IPR027417;IPR029295 6595 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 [S None not tested not tested None None No No TF Gene_Transcription Factor Binding: tf co-factor binding_Co-activation_PMIDS:8223438;8895581 No 5a, one of the source datasets predicts is as a TF Jussi Taipale Tim Hughes No None $##ENSG00000080503##Other# FALSE 2538 ENSG00000127616 SMARCA4 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif Has a putative AT-hook (PMID: 24752179) shows via ChIP that it has DNA mediated regulatory activity, but unknown if this is direct or indirect binding. No clear DBD present in the protein. IPR000330;IPR001487;IPR001650;IPR006576;IPR013999;IPR014001;IPR014012;IPR014978;IPR018359;IPR027417;IPR029295 6597 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 [S None not tested not tested None None No No TF Gene Candidate_Transcription Factor Binding: tf co-factor binding; Transcription Regulatory Activity: heterochromatin interaction/binding_TF PPI_PMIDS:12244326 Yes 4a, two or more datasets predict it as a TF Jussi Taipale Pratyush Das No $#ENSG00000127616#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:11950834, PMID:17938176 $#ENSP00000343896#ENSG00000127616#ENST00000344626#Other#BRK, Bromodomain, DEAD, HSA, Helicase_C, QLQ, ResI$#ENSP00000395654#ENSG00000127616#ENST00000429416#Other#BRK, Bromodomain, DEAD, HSA, Helicase_C, QLQ, ResI$#ENSP00000467200#ENSG00000127616#ENST00000592158#Other#Helicase_C, SnAC FALSE 2539 ENSG00000138375 SMARCAL1 Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None Is a DNA binding helicase IPR000330;IPR001650;IPR010003;IPR014001;IPR027417 50485 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1 [Sour None not tested not tested None None No No TF Gene Candidate__DNA Binding_PMIDS:10857751 No 5a, one of the source datasets predicts is as a TF Arttu Jolma Sam Lambert No None $##ENSG00000138375##Other# FALSE 2540 ENSG00000099956 SMARCB1 Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None Alias INI1 is a minor groove DNA-binding protein (PMID: 19398554) IPR006939;IPR017393 6598 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 [S None not tested not tested None None No No TF Gene_Transcription Regulatory Activity: heterochromatin interaction/binding_Non-specific DNA_PMIDS:16267391 Yes 4a, two or more datasets predict it as a TF Matt Weirauch Pratyush Das No $#ENSG00000099956#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:11950834 $#ENSP00000263121#ENSG00000099956#ENST00000263121#Other#DUF1679, SNF5$#ENSP00000383984#ENSG00000099956#ENST00000407422#Other#DUF1679, SNF5$#ENSP00000489445#ENSG00000099956#ENST00000634926#Other#$#ENSP00000489115#ENSG00000099956#ENST00000635578#Other#$#ENSP00000340883#ENSG00000099956#ENST00000344921#Other#DUF1679, SNF5$#ENSP00000388489#ENSG00000099956#ENST00000417137#Other#SNF5 FALSE 2541 ENSG00000066117 SMARCD1 Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None It is an active ATP-utilizing chromatin remodeling protein (PMID: 25818293) IPR003121;IPR019835 6602 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 [S None not tested not tested None None No No TF Gene_Transcription Regulatory Activity: heterochromatin interaction/binding_Other_PMIDS:8804307;15525990 No 5a, one of the source datasets predicts is as a TF Arttu Jolma Pratyush Das No None $##ENSG00000066117##Other# FALSE 2542 ENSG00000108604 SMARCD2 Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None Transcriptional cofactor (PMID: 8804307) IPR003121;IPR019835 6603 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 [S None not tested not tested None None No No TF Gene Candidate_Transcription Regulatory Activity: heterochromatin interaction/binding_TF PPI_PMIDS:8804307;9427560 No 5a, one of the source datasets predicts is as a TF Matt Weirauch Laura Campitelli No None $##ENSG00000108604##Other# FALSE 2543 ENSG00000082014 SMARCD3 Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None Chromatin remodelling complex component IPR003121;IPR019835 6604 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 [S None not tested not tested None None No No TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_Co-activation_PMIDS:14701856;15525990 No 5a, one of the source datasets predicts is as a TF Pratyush Das Arttu Jolma No None $##ENSG00000082014##Other# FALSE 2544 ENSG00000108055 SMC3 Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain Binds and compacts DNA as a SMC1-SMC3 heterodimer that is part of the cohesin complex (PMID: 23620281). Transfac motifs likely reflect the binding of other TFs such as CTCF that associate with cohesin IPR003395;IPR010935;IPR027417 9126 structural maintenance of chromosomes 3 [Source:HGNC Symbol;Acc:HGNC:2468] None not tested not tested None None No Yes No No 2a1, Lower confidence direct evidence Arttu Jolma Yimeng Yin No None $#ENSP00000354720#ENSG00000108055#ENST00000361804#Other#AAA_15, AAA_21, AAA_23, AAA_29, SMC_N, SMC_hinge FALSE 2545 ENSG00000128602 SMO Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None The protein is a G-protein coupled receptor IPR000539;IPR017981;IPR020067 6608 smoothened, frizzled class receptor [Source:HGNC Symbol;Acc:HGNC:11119] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Arttu Jolma Pratyush Das No $#ENSG00000128602#GO:0007228#positive regulation of hh target transcription factor activity#ISS - GO_REF:0000024 $#ENSP00000249373#ENSG00000128602#ENST00000249373#Other#Dicty_CAR, Frizzled, Fz FALSE 2546 ENSG00000123415 SMUG1 Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None Involved in DNA mismatch repair. Xenopus homolog binds dsDNA in the crystal structure (PDB: 1OE4) None 23583 single-strand-selective monofunctional uracil-DNA glycosylase 1 1OE4 not tested not tested None None No No No No New proteins added based on PDB entry Arttu Jolma Sam Lambert No None None FALSE 2547 ENSG00000115593 SMYD1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR001214;IPR002893 150572 SET and MYND domain containing 1 [Source:HGNC Symbol;Acc:HGNC:20986] None not tested not tested None None No No TF Gene Candidate_Transcription Regulatory Activity: heterochromatin interaction/binding; Transcription Factor Binding: tf co-factor binding_TF PPI; Transactivation_PMIDS:11923873;12011100 No 5a, one of the source datasets predicts is as a TF Yimeng Yin Jussi Taipale No None $##ENSG00000115593##Other# FALSE 2548 ENSG00000185420 SMYD3 Unknown Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Binds GGAGGG elements based on SELEX performed using GST fusion protein (PMID: 15235609) IPR001214;IPR002893;IPR025805 64754 SET and MYND domain containing 3 [Source:HGNC Symbol;Acc:HGNC:15513] None not tested not tested None None No No TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_Co-activation; DNA Binding; TF PPI; Transactivation_PMIDS:15235609;15303093;16155568 No 5a, one of the source datasets predicts is as a TF Arttu Jolma Laura Campitelli No None $##ENSG00000185420##Other# FALSE 2549 ENSG00000104976 SNAPC2 Unknown Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Recognizes the PSE-element, which is located in the core promoters of snRNA genes, and helps to recruit TBP (PMID: 8633057) IPR021281 6618 small nuclear RNA activating complex polypeptide 2 [Source:HGNC Symbol;Acc:HGNC:11135] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Arttu Jolma Pratyush Das No $#ENSG00000104976#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:7715707, PMID:8524284 $#ENSP00000221573#ENSG00000104976#ENST00000221573#Other#SnAPC_2_like$#ENSP00000471962#ENSG00000104976#ENST00000597584#Other#SnAPC_2_like$#ENSP00000469475#ENSG00000104976#ENST00000595637#Other#SnAPC_2_like FALSE 2550 ENSG00000174446 SNAPC5 Unknown Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Binds specifically to the PSE (PMID: 9732265) IPR029138 10302 small nuclear RNA activating complex polypeptide 5 [Source:HGNC Symbol;Acc:HGNC:15484] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Jussi Taipale Yimeng Yin No $#ENSG00000174446#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002 $#ENSP00000308439#ENSG00000174446#ENST00000307979#Other#GDE_N, SNAPc19$#ENSP00000319597#ENSG00000174446#ENST00000316634#Other#DUF4724, SNAPc19$#ENSP00000378954#ENSG00000174446#ENST00000395589#Other#DUF4724, SNAPc19$#ENSP00000457892#ENSG00000174446#ENST00000563480#Other#DUF4724, SNAPc19 FALSE 2551 ENSG00000124562 SNRPC Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Component of the spliceosomal U1 snRNP IPR000690;IPR003604;IPR013085;IPR017340 6631 small nuclear ribonucleoprotein polypeptide C [Source:HGNC Symbol;Acc:HGNC:11157] None not tested not tested None None No No TF Evidence Conflict - There is evidence for and against this genes role as a TF__TF PPI_PMIDS:10827180; No 5a, one of the source datasets predicts is as a TF Laura Campitelli Yimeng Yin No None $##ENSG00000124562##Other# FALSE 2552 ENSG00000273173 SNURF Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Likely a TF co-factor IPR009847 8926 SNRPN upstream reading frame [Source:HGNC Symbol;Acc:HGNC:11171] None not tested not tested None None No No TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:9710597 No 5a, one of the source datasets predicts is as a TF Pratyush Das Sam Lambert No None $##ENSG00000273173##Other# FALSE 2553 ENSG00000100603 SNW1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR004015 22938 SNW domain containing 1 [Source:HGNC Symbol;Acc:HGNC:16696] None not tested not tested None None No No TF Gene_Transcription Factor Binding: tf co-factor binding_Co-activation; TF PPI_PMIDS:9632709 No 5a, one of the source datasets predicts is as a TF Jussi Taipale Matt Weirauch No None $##ENSG00000100603##Other# FALSE 2554 ENSG00000214338 SOGA3 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Does not contain any likely DBDs. IPR027881 387104 SOGA family member 3 [Source:HGNC Symbol;Acc:HGNC:21494] None not tested not tested None None No Yes No No 5a, one of the source datasets predicts is as a TF Laura Campitelli Jussi Taipale No None $#ENSP00000431662#ENSG00000214338#ENST00000467753#bZIP#$#ENSP00000435559#ENSG00000214338#ENST00000465909#bZIP#SOGA, TSC22$#ENSP00000434570#ENSG00000214338#ENST00000525778#bZIP#SOGA, TSC22 FALSE 2555 ENSG00000159140 SON Unknown Yes Likely to be sequence specific TF Monomer or homomultimer No motif None The protein has been reported to bind a GAKANSRCC consensus based on SELEX experiments. Recognizes a matching GAGACCACC sequence in a hepatitis B virus regulatory element (PMID: 11306577) IPR000467;IPR014720;IPR017986 102465248 SON DNA binding protein [Source:HGNC Symbol;Acc:HGNC:11183] None not tested not tested None None No No Indeterminate - There is no evidence for or against this genes role as a TF__Other_PMIDS:1424986 No 5a, one of the source datasets predicts is as a TF Jussi Taipale Arttu Jolma No None $##ENSG00000159140##Other# FALSE 2556 ENSG00000154556 SORBS2 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR001452;IPR003127;IPR007087; 8470 sorbin and SH3 domain containing 2 [Source:HGNC Symbol;Acc:HGNC:24098] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Laura Campitelli Yimeng Yin No None $#ENSP00000284776#ENSG00000154556#ENST00000284776#Other#SH3_1, SH3_2, SH3_9, Sorb$#ENSP00000321983#ENSG00000154556#ENST00000319454#Other#SH3_1, SH3_2, SH3_9, Sorb$#ENSP00000322182#ENSG00000154556#ENST00000319471#Other#SH3_1, SH3_2, SH3_9, Sorb$#ENSP00000377162#ENSG00000154556#ENST00000393528#Other#SH3_1, SH3_2, SH3_9, Sorb$#ENSP00000396008#ENSG00000154556#ENST00000437304#Other#SH3_1, SH3_2, SH3_9, Sorb$#ENSP00000397262#ENSG00000154556#ENST00000449407#Other#SH3_1, SH3_2, SH3_9, Sorb$#ENSP00000347852#ENSG00000154556#ENST00000355634#Other#SH3_1, SH3_2, SH3_9, Sorb$#ENSP00000397482#ENSG00000154556#ENST00000418609#Other#SH3_1, SH3_2, SH3_9, Sorb$#ENSP00000415637#ENSG00000154556#ENST00000425679#Other#$#ENSP00000410483#ENSG00000154556#ENST00000444771#Other#Sorb$#ENSP00000409158#ENSG00000154556#ENST00000448662#Other#SH3_1, SH3_2, SH3_9, Sorb$#ENSP00000408504#ENSG00000154556#ENST00000419063#Other#$#ENSP00000405646#ENSG00000154556#ENST00000421639#Other#$#ENSP00000407006#ENSG00000154556#ENST00000432655#Other#$#ENSP00000404430#ENSG00000154556#ENST00000451701#Other# FALSE 2557 ENSG00000065526 SPEN Unknown Yes Likely to be sequence specific TF Monomer or homomultimer No motif Has a putative AT-hook Data inconclusive. Contains RRM domains, suggesting RNA binding activity. Gel-shift experiments demonstrate that SPEN (aka MINT) binds ss and dsDNA G- and T-rich elements (PMID: 10451362), but in another system SPEN does not bind DNA directly and is recruited (PMID: 15778499). RNA-binding activities have also been documented (PMID: 24748666). IPR000504;IPR010912;IPR012921;IPR016194 23013 spen family transcriptional repressor [Source:HGNC Symbol;Acc:HGNC:17575] None not tested not tested None None No No TF Gene Candidate_Single stranded RNA/DNA binding_DNA Binding_PMIDS:10451362;15778499 No 5a, one of the source datasets predicts is as a TF Sam Lambert Matt Weirauch No None $##ENSG00000065526##Other# FALSE 2558 ENSG00000176170 SPHK1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR001206;IPR016064 8877 sphingosine kinase 1 [Source:HGNC Symbol;Acc:HGNC:11240] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Yimeng Yin Sam Lambert No $#ENSG00000176170#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IMP - PMID:20577214 $#ENSP00000313681#ENSG00000176170#ENST00000323374#Other#DAGK_cat$#ENSP00000376285#ENSG00000176170#ENST00000392496#Other#DAGK_cat$#ENSP00000468547#ENSG00000176170#ENST00000590959#Other#DAGK_cat$#ENSP00000465726#ENSG00000176170#ENST00000592299#Other#DAGK_cat$#ENSP00000440970#ENSG00000176170#ENST00000545180#Other#DAGK_cat$#ENSP00000466422#ENSG00000176170#ENST00000588682#Other#DAGK_cat$#ENSP00000465002#ENSG00000176170#ENST00000590379#Other#DAGK_cat FALSE 2559 ENSG00000164299 SPZ1 Unknown Yes Known motif Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain Binds to E-boxes (EMSA) (PMID: 15226296) IPR029780 84654 spermatogenic leucine zipper 1 [Source:HGNC Symbol;Acc:HGNC:30721] None Full Yes None None No Yes TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:11165476 Yes 2a1, Lower confidence direct evidence Pratyush Das Laura Campitelli No $#ENSG00000164299#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002 $#ENSP00000426530#ENSG00000164299#ENST00000511881#Other#PCRF$#ENSP00000369611#ENSG00000164299#ENST00000296739#Other#DUF3150 FALSE 2560 ENSG00000138385 SSB Unknown No ssDNA/RNA binding Not a DNA binding protein No motif None Binds to the 3 poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation (PMID: 3192525; PMID: 2470590] IPR000504;IPR002344;IPR006630;IPR014886 6741 Sjogren syndrome antigen B [Source:HGNC Symbol;Acc:HGNC:11316] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Yimeng Yin Laura Campitelli No None $#ENSP00000260956#ENSG00000138385#ENST00000260956#Other#La$#ENSP00000386636#ENSG00000138385#ENST00000409333#Other#La$#ENSP00000396890#ENSG00000138385#ENST00000417292#Other#$#ENSP00000397029#ENSG00000138385#ENST00000422006#Other#La FALSE 2561 ENSG00000145687 SSBP2 Unknown No ssDNA/RNA binding Not a DNA binding protein No motif None Binds single stranded DNA in DNA damage response. Has domain IPR008116 Sequence-specific single-strand DNA-binding protein None 23635 Single-stranded DNA-binding protein 2 None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Sam Lambert Arttu Jolma No $#ENSG00000145687#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IBA - GO_REF:0000033 $##ENSG00000145687##Other# FALSE 2562 ENSG00000157216 SSBP3 Unknown No ssDNA/RNA binding Not a DNA binding protein No motif None Single stranded DNA binding protein. There is no evidence for sequence specificity, although it can operate as a transcriptional co-regulator (PMID: 26495868) None 23648 Single-stranded DNA-binding protein 3 None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Yimeng Yin Arttu Jolma No $#ENSG00000157216#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IBA - GO_REF:0000033 $##ENSG00000157216##Other# FALSE 2563 ENSG00000130511 SSBP4 Unknown No ssDNA/RNA binding Not a DNA binding protein No motif None (PMID:9531483) shows that the SSDP_DNA-bd domain has sequence-specific single-stranded DNA-binding activity. None 170463 Single-stranded DNA-binding protein 4 None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Laura Campitelli Tim Hughes No $#ENSG00000130511#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IBA - GO_REF:0000033 $##ENSG00000130511##Other# FALSE 2564 ENSG00000084112 SSH1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000340;IPR000387;IPR014876;IPR016130;IPR020422;IPR029021 54434 slingshot protein phosphatase 1 [Source:HGNC Symbol;Acc:HGNC:30579] None Full not tested None None x No No No 5a, one of the source datasets predicts is as a TF Matt Weirauch Laura Campitelli No None $#ENSP00000315713#ENSG00000084112#ENST00000326495#Other#DEK_C, DSPc$#ENSP00000448824#ENSG00000084112#ENST00000551165#Other#DEK_C, DSPc$#ENSP00000326107#ENSG00000084112#ENST00000326470#Other#DEK_C, DSPc$#ENSP00000446652#ENSG00000084112#ENST00000546697#Other# FALSE 2565 ENSG00000141298 SSH2 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000340;IPR000387;IPR014876;IPR016130;IPR020422;IPR029021 85464 slingshot protein phosphatase 2 [Source:HGNC Symbol;Acc:HGNC:30580] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Yimeng Yin Laura Campitelli No None $#ENSP00000269033#ENSG00000141298#ENST00000269033#Other#DEK_C, DSPc$#ENSP00000444743#ENSG00000141298#ENST00000540801#Other#DEK_C, DSPc$#ENSP00000465703#ENSG00000141298#ENST00000577991#Other#$#ENSP00000468037#ENSG00000141298#ENST00000579954#Other#$#ENSP00000462583#ENSG00000141298#ENST00000582084#Other# FALSE 2566 ENSG00000172830 SSH3 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000340;IPR000387;IPR014876;IPR016130;IPR020422;IPR029021 54961 slingshot protein phosphatase 3 [Source:HGNC Symbol;Acc:HGNC:30581] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Matt Weirauch Pratyush Das No None $#ENSP00000312081#ENSG00000172830#ENST00000308127#Other#DEK_C, DSPc, Y_phosphatase$#ENSP00000310055#ENSG00000172830#ENST00000308298#Other#$#ENSP00000365948#ENSG00000172830#ENST00000376757#Other#DEK_C, DSPc, Y_phosphatase$#ENSP00000433902#ENSG00000172830#ENST00000527821#Other#DEK_C, DSPc, Y_phosphatase$#ENSP00000480198#ENSG00000172830#ENST00000532181#Other#DEK_C, DSPc FALSE 2567 ENSG00000126752 SSX1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR001909;IPR003655;IPR019041 6756 SSX family member 1 [Source:HGNC Symbol;Acc:HGNC:11335] None not tested not tested None None No No Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0 No 5a, one of the source datasets predicts is as a TF Sam Lambert Laura Campitelli No None $##ENSG00000126752##Other# FALSE 2568 ENSG00000118007 STAG1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif Has a putative AT-hook Part of the cohesin complex None 10274 Cohesin subunit SA-1 None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Pratyush Das Matt Weirauch No $#ENSG00000118007#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IEA - GO_REF:0000019 $##ENSG00000118007##Other# FALSE 2569 ENSG00000115661 STK16 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None None 8576 Serine/threonine-protein kinase 16 None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Laura Campitelli Matt Weirauch No $#ENSG00000115661#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019 $##ENSG00000115661##Other# FALSE 2570 ENSG00000104375 STK3 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Kinase - included only because GO says it regulates TFs IPR000719;IPR002290;IPR011009;IPR011524;IPR017441;IPR024205 6788 serine/threonine kinase 3 [Source:HGNC Symbol;Acc:HGNC:11406] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Jussi Taipale Tim Hughes No $#ENSG00000104375#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IGI - PMID:22292086 $#ENSP00000390500#ENSG00000104375#ENST00000419617#Other#Mst1_SARAH, Pkinase, Pkinase_Tyr$#ENSP00000428014#ENSG00000104375#ENST00000518165#Other#Pkinase, Pkinase_Tyr$#ENSP00000429744#ENSG00000104375#ENST00000523601#Other#Mst1_SARAH, Pkinase, Pkinase_Tyr$#ENSP00000428295#ENSG00000104375#ENST00000519420#Other# FALSE 2571 ENSG00000163482 STK36 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000719;IPR002290;IPR008271;IPR011009;IPR016024;IPR017441 27148 serine/threonine kinase 36 [Source:HGNC Symbol;Acc:HGNC:17209] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Pratyush Das Jussi Taipale No $#ENSG00000163482#GO:0007228#positive regulation of hh target transcription factor activity#ISS - GO_REF:0000024$#ENSG00000163482#GO:0051090#regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:10806483 $#ENSP00000295709#ENSG00000163482#ENST00000295709#Other#APH, Cnd1, HEAT, HEAT_2, HEAT_EZ, Kinase-like, Pki$#ENSP00000375954#ENSG00000163482#ENST00000392105#Other#APH, Cnd1, HEAT, HEAT_2, HEAT_EZ, Kinase-like, Pki$#ENSP00000400055#ENSG00000163482#ENST00000455724#Other#Pkinase, Pkinase_Tyr FALSE 2572 ENSG00000115808 STRN Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR001680;IPR013258;IPR017986;IPR019775;IPR020472 6801 striatin [Source:HGNC Symbol;Acc:HGNC:11424] None not tested not tested None None No No TF Gene Candidate__Transactivation_PMIDS:11570823 No 5a, one of the source datasets predicts is as a TF Matt Weirauch Yimeng Yin No None $##ENSG00000115808##Other# FALSE 2573 ENSG00000196792 STRN3 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None GO annotation has no evidence for DNA-binding activity (PMID: 11570823), and STRN3 lacks a canonical DBD IPR001680;IPR013258;IPR017986;IPR019775;IPR020472 29966 striatin 3 [Source:HGNC Symbol;Acc:HGNC:15720] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Sam Lambert Pratyush Das No None $#ENSP00000347909#ENSG00000196792#ENST00000355683#Other#ANAPC4_WD40, Nup160, Striatin, WD40$#ENSP00000451233#ENSG00000196792#ENST00000555152#Other#Striatin FALSE 2574 ENSG00000113387 SUB1 Unknown No ssDNA/RNA binding Not a DNA binding protein No motif None The structure (PDB: 2C62) demonstrates binding to single stranded DNA IPR003173;IPR009044 10923 SUB1 homolog, transcriptional regulator [Source:HGNC Symbol;Acc:HGNC:19985] 2C62 not tested not tested None None No No TF Gene_Basal Transcription Factor_TF PPI_PMIDS:9482861 No 5a, one of the source datasets predicts is as a TF Arttu Jolma Jussi Taipale No $#ENSG00000113387#GO:0001205#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involv#IEA - GO_REF:0000019 $##ENSG00000113387##Other# FALSE 2575 ENSG00000107882 SUFU Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR016591;IPR020941;IPR024314 51684 SUFU negative regulator of hedgehog signaling [Source:HGNC Symbol;Acc:HGNC:16466] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Yimeng Yin Sam Lambert No $#ENSG00000107882#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#TAS - PMID:11001584 $#ENSP00000358915#ENSG00000107882#ENST00000369899#Other#SUFU, SUFU_C$#ENSP00000358918#ENSG00000107882#ENST00000369902#Other#SUFU, SUFU_C$#ENSP00000411597#ENSG00000107882#ENST00000423559#Other#SUFU, SUFU_C FALSE 2576 ENSG00000116030 SUMO1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000626;IPR022617;IPR029071 7341 small ubiquitin-like modifier 1 [Source:HGNC Symbol;Acc:HGNC:12502] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Yimeng Yin Matt Weirauch No $#ENSG00000116030#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#IMP - PMID:12072434 $#ENSP00000376077#ENSG00000116030#ENST00000392246#Other#Rad60-SLD, ubiquitin$#ENSP00000376075#ENSG00000116030#ENST00000392244#Other#Rad60-SLD, ubiquitin$#ENSP00000386267#ENSG00000116030#ENST00000409205#Other#Rad60-SLD, ubiquitin$#ENSP00000386296#ENSG00000116030#ENST00000409712#Other#Rad60-SLD, ubiquitin$#ENSP00000376076#ENSG00000116030#ENST00000392245#Other#Rad60-SLD, ubiquitin$#ENSP00000386753#ENSG00000116030#ENST00000409181#Other#Rad60-SLD, ubiquitin$#ENSP00000386472#ENSG00000116030#ENST00000409498#Other#Rad60-SLD, ubiquitin FALSE 2577 ENSG00000092201 SUPT16H Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Component of the FACT histone remodeling complex, which functions in transcriptional elongation (PMID: 12934006). (PDB: 4Z2M) shows that the protein contacts H3 and H4 proteins, but it could also contact DNA IPR000994;IPR013719;IPR013953;IPR029148 11198 SPT16 homolog, facilitates chromatin remodeling subunit [Source:HGNC Symbol;Acc:HGNC:11465] None not tested not tested None None No No TF Gene Candidate_Transcription Regulatory Activity: heterochromatin interaction/binding_Non-specific DNA_PMIDS:12934006;10421373;12934006 No 5a, one of the source datasets predicts is as a TF Arttu Jolma Laura Campitelli No None $##ENSG00000092201##Other# FALSE 2578 ENSG00000213246 SUPT4H1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Involved in transcription elongation (PMID: 9450929) IPR009287;IPR022800;IPR029040 6827 SPT4 homolog, DSIF elongation factor subunit [Source:HGNC Symbol;Acc:HGNC:11467] None not tested not tested None None No No TF Evidence Conflict - There is evidence for and against this genes role as a TF_Transcription Factor Binding: tf co-factor binding_Other_PMIDS:8649394;8660457;8786137;11101522;12653964 Yes 4a, two or more datasets predict it as a TF Jussi Taipale Laura Campitelli No $#ENSG00000213246#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:8649394 $#ENSP00000225504#ENSG00000213246#ENST00000225504#Other#Spt4$#ENSP00000462100#ENSG00000213246#ENST00000577396#Other#Spt4$#ENSP00000464618#ENSG00000213246#ENST00000581540#Other#Spt4$#ENSP00000462670#ENSG00000213246#ENST00000580947#Other#Spt4 FALSE 2579 ENSG00000196235 SUPT5H Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None Protein that regulates transcriptional elongation (PMID: 9450929) IPR005100;IPR005824;IPR006645;IPR008991;IPR017071;IPR022581;IPR024945 6829 SPT5 homolog, DSIF elongation factor subunit [Source:HGNC Symbol;Acc:HGNC:11469] None not tested not tested None None No No TF Gene_Transcription Factor Binding: tf co-factor binding_Other_PMIDS:9450929 No 5a, one of the source datasets predicts is as a TF Arttu Jolma Pratyush Das No None $##ENSG00000196235##Other# FALSE 2580 ENSG00000109111 SUPT6H Unknown No ssDNA/RNA binding Not a DNA binding protein No motif None SPT6 is an elongation factor, not a TF. GO needs to be corrected - (PMID: 8786132) does not demonstrate sequence specificity or DNA binding. IPR000980;IPR003029;IPR006641;IPR010994;IPR012337;IPR012340;IPR017072;IPR022967;IPR027999;IPR028083;IPR028088; 6830 SPT6 homolog, histone chaperone [Source:HGNC Symbol;Acc:HGNC:11470];Transcription elongation factor None not tested not tested None None No No Not a TF - Evidence that it is not a TF___PMIDS:0 Yes 5a, one of the source datasets predicts is as a TF Tim Hughes Laura Campitelli No $#ENSG00000109111#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:8786132 $#ENSP00000319104#ENSG00000109111#ENST00000314616#Other#DLD, HHH_3, HHH_7, HTH_44, S1, SH2, SH2_2, SPT6_ac$#ENSP00000338143#ENSG00000109111#ENST00000347486#Other#DLD, HHH_3, HHH_7, HTH_44, S1, SH2, SH2_2, SPT6_ac$#ENSP00000464545#ENSG00000109111#ENST00000577713#Other#MRC1 FALSE 2581 ENSG00000101945 SUV39H1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Protein is a histone methyltransferase that trimethylates lysine 9 of histone H3 IPR000953;IPR001214;IPR003606;IPR003616;IPR007728;IPR011381;IPR016197;IPR023779;IPR023780 6839 suppressor of variegation 3-9 homolog 1 [Source:HGNC Symbol;Acc:HGNC:11479] None not tested not tested None None No No TF Gene_Transcription Factor Binding: tf co-factor binding_Co-activation_PMIDS:15107829 No 5a, one of the source datasets predicts is as a TF Arttu Jolma Laura Campitelli No None $##ENSG00000101945##Other# FALSE 2582 ENSG00000152455 SUV39H2 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Histone (H3K9) methyltransferase. Also directs DNA methylation (UniProt: Q9H5I1) (PMID: 14765126) IPR000953;IPR001214;IPR003606;IPR003616;IPR007728;IPR011381;IPR016197;IPR023779;IPR023780 79723 suppressor of variegation 3-9 homolog 2 [Source:HGNC Symbol;Acc:HGNC:17287] None not tested not tested None None No No TF Gene Candidate_Transcription Factor Binding: tf co-factor binding; Transcription Regulatory Activity: heterochromatin interaction/binding_Other_PMIDS:11094092;15107829 No 5a, one of the source datasets predicts is as a TF Arttu Jolma Laura Campitelli No None $##ENSG00000152455##Other# FALSE 2583 ENSG00000178691 SUZ12 Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None Protein is a component of the PRC2 repressor complex, which silences DNA through histone methylation. The protein has two znf C2H2-like domains that appear to be used in association with chromatin (PMID: 24100017) IPR019135; 23512 SUZ12 polycomb repressive complex 2 subunit [Source:HGNC Symbol;Acc:HGNC:17101] None Full not tested None None x No TF Gene_Transcription Factor Binding: tf co-factor binding_DNA Binding_PMIDS:15225548;16751344 No 4a, two or more datasets predict it as a TF Pratyush Das Arttu Jolma No None $#ENSP00000316578#ENSG00000178691#ENST00000322652#Other#DUF2070, VEFS-Box$#ENSP00000463936#ENSG00000178691#ENST00000580398#Other#DUF2070, VEFS-Box FALSE 2584 ENSG00000165025 SYK Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Known co-factor IPR000719;IPR000980;IPR001245;IPR008266;IPR011009;IPR012234;IPR017441;IPR020635 6850 spleen tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:11491] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Matt Weirauch Pratyush Das No $#ENSG00000165025#GO:0051090#regulation of sequence-specific DNA binding transcription factor activity#IMP - PMID:23071339 $#ENSP00000364898#ENSG00000165025#ENST00000375746#Other#Kdo, Pkinase, Pkinase_Tyr, SH2$#ENSP00000364899#ENSG00000165025#ENST00000375747#Other#Kdo, Pkinase, Pkinase_Tyr, SH2$#ENSP00000364904#ENSG00000165025#ENST00000375751#Other#Kdo, Pkinase, Pkinase_Tyr, SH2$#ENSP00000364907#ENSG00000165025#ENST00000375754#Other#Kdo, Pkinase, Pkinase_Tyr, SH2 FALSE 2585 ENSG00000100324 TAB1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR001932 10454 TGF-beta activated kinase 1/MAP3K7 binding protein 1 [Source:HGNC Symbol;Acc:HGNC:18157] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Yimeng Yin Matt Weirauch No $#ENSG00000100324#GO:0051092#positive regulation of NF-kappaB transcription factor activity#TAS - Reactome:R-HSA-445989 $#ENSP00000216160#ENSG00000100324#ENST00000216160#Other#PP2C$#ENSP00000333049#ENSG00000100324#ENST00000331454#Other#PP2C FALSE 2586 ENSG00000055208 TAB2 Unknown No ssDNA/RNA binding Not a DNA binding protein No motif None Works as a protein-protein interaction adapter to recruit TAK1-kinase (PMID: 10882101). Could also work as an RBP, based on presence of a zf-RanBP domain IPR001876;IPR003892 23118 TGF-beta activated kinase 1/MAP3K7 binding protein 2 [Source:HGNC Symbol;Acc:HGNC:17075] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Arttu Jolma Sam Lambert No $#ENSG00000055208#GO:0051092#positive regulation of NF-kappaB transcription factor activity#TAS - Reactome:R-HSA-445989 $#ENSP00000476139#ENSG00000055208#ENST00000606202#Other#$#ENSP00000490379#ENSG00000055208#ENST00000636456#Other#zf-RanBP$#ENSP00000490618#ENSG00000055208#ENST00000637181#Other#CUE, zf-RanBP FALSE 2587 ENSG00000157625 TAB3 Unknown No ssDNA/RNA binding Not a DNA binding protein No motif None None IPR001876;IPR003892 257397 TGF-beta activated kinase 1/MAP3K7 binding protein 3 [Source:HGNC Symbol;Acc:HGNC:30681] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Yimeng Yin Sam Lambert No $#ENSG00000157625#GO:0051092#positive regulation of NF-kappaB transcription factor activity#TAS - Reactome:R-HSA-445989 $#ENSP00000368212#ENSG00000157625#ENST00000378930#Other#CUE, zf-RanBP$#ENSP00000368214#ENSG00000157625#ENST00000378932#Other#CUE, zf-RanBP$#ENSP00000368215#ENSG00000157625#ENST00000378933#Other#CUE, zf-RanBP$#ENSP00000288422#ENSG00000157625#ENST00000288422#Other#CUE FALSE 2588 ENSG00000171148 TADA3 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif Has a putative AT-hook Paper cited by GO annotation has no evidence of specific DNA-binding activity (PMID: 9674425), and is based on experiments using an entire complex IPR019340 10474 transcriptional adaptor 3 [Source:HGNC Symbol;Acc:HGNC:19422] None not tested not tested None None No No TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:12034840 Yes 4a, two or more datasets predict it as a TF Yimeng Yin Sam Lambert No $#ENSG00000171148#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:9674425 $#ENSP00000307684#ENSG00000171148#ENST00000301964#Other#Ada3$#ENSP00000343649#ENSG00000171148#ENST00000343450#Other#Ada3$#ENSP00000395073#ENSG00000171148#ENST00000439043#Other#$#ENSP00000393471#ENSG00000171148#ENST00000440161#Other#Ada3 FALSE 2589 ENSG00000147133 TAF1 Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain Contacts DNA in the structure (PDB: 5FUR). Transfac motifs are suspect, and are probably in vivo signals derived from promoter binding TFs (e.g. YY1 and ETS) IPR001487;IPR009067;IPR011177;IPR018359;IPR022591 6872 TATA-box binding protein associated factor 1 [Source:HGNC Symbol;Acc:HGNC:11535];Transcription initi 5FUR not tested not tested None None No Yes No Yes 2a1, Lower confidence direct evidence Arttu Jolma Pratyush Das Yes $#ENSG00000147133#GO:0001075#RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved#IBA - GO_REF:0000033$#ENSG00000147133#GO:2000825#positive regulation of androgen receptor activity#IDA - PMID:20181722 $#ENSP00000362895#ENSG00000147133#ENST00000373790#Other#Bromodomain, DUF3591, TBP-binding, zf-CCHC_6$#ENSP00000421611#ENSG00000147133#ENST00000463163#Other#Bromodomain$#ENSP00000424526#ENSG00000147133#ENST00000483985#Other#zf-CCHC_6 FALSE 2590 ENSG00000166337 TAF10 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None General transcription factor IPR003923 6881 TATA-box binding protein associated factor 10 [Source:HGNC Symbol;Acc:HGNC:11543] None not tested not tested None None No No TF Gene Candidate_Transcription Factor Binding: tf co-factor binding; Basal Transcription Factor_TF PPI; Transactivation_PMIDS:7923369 Yes 4a, two or more datasets predict it as a TF Laura Campitelli Jussi Taipale No $#ENSG00000166337#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:9603525 $#ENSP00000299424#ENSG00000166337#ENST00000299424#Other#Bromo_TP, TFIID_30kDa$#ENSP00000480402#ENSG00000166337#ENST00000527248#Other#Bromo_TP, TFIID_30kDa FALSE 2591 ENSG00000064995 TAF11 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Does not interact with DNA (PMID: 15657423) IPR006809;IPR009072 6882 TATA-box binding protein associated factor 11 [Source:HGNC Symbol;Acc:HGNC:11544] None not tested not tested None None No No TF Gene_Basal Transcription Factor; Transcription Factor Binding: tf co-factor binding_Co-activation_PMIDS:8670810;9108034 No 5a, one of the source datasets predicts is as a TF Pratyush Das Yimeng Yin No None $##ENSG00000064995##Other# FALSE 2592 ENSG00000120656 TAF12 Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None (PMID: 15601843) shows it has DNA binding activity in a complex with TAF4b. IPR003228;IPR009072 6883 TATA-box binding protein associated factor 12 [Source:HGNC Symbol;Acc:HGNC:11545] None not tested not tested None None No No TF Gene_Basal Transcription Factor; Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:7729427;15735663 Yes 4a, two or more datasets predict it as a TF Pratyush Das Laura Campitelli No $#ENSG00000120656#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:9603525$#ENSG00000120656#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:15735663 $#ENSP00000263974#ENSG00000120656#ENST00000263974#Other#CBFD_NFYB_HMF, CENP-T_C, Histone, TFIID-31kDa, TFI$#ENSP00000362930#ENSG00000120656#ENST00000373824#Other#CBFD_NFYB_HMF, CENP-T_C, Histone, TFIID-31kDa, TFI FALSE 2593 ENSG00000197780 TAF13 Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None Forms heterodimer TAF11:TAF13, which has a histone-fold like structure and could thus bind DNA in a non- or low specific manner (PMID: 9695952) IPR003195;IPR009072 6884 TATA-box binding protein associated factor 13 [Source:HGNC Symbol;Acc:HGNC:11546];Transcription init None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Pratyush Das Arttu Jolma No $#ENSG00000197780#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:9695952 $#ENSP00000355051#ENSG00000197780#ENST00000338366#Other#TFIID-18kDa FALSE 2594 ENSG00000143498 TAF1A Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None General TF. Directly binds to DNA, likely in a non sequence-specific manner (PMID: 15970593), although it is possible it might have some specificity. IPR016629 9015 TATA-box binding protein associated factor, RNA polymerase I subunit A [Source:HGNC Symbol;Acc:HGNC: None not tested not tested None None No No TF Gene_Basal Transcription Factor__PMIDS:0;8013460 No 5a, one of the source datasets predicts is as a TF Laura Campitelli Yimeng Yin No None $##ENSG00000143498##Other# FALSE 2595 ENSG00000115750 TAF1B Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None Pol I TAF that contacts the rDNA promoter in conjunction with TBP and UBF (PMID: 7491500). No clear evidence that it directly confers sequence specificity. IPR021752 9014 TATA-box binding protein associated factor, RNA polymerase I subunit B [Source:HGNC Symbol;Acc:HGNC: None not tested not tested None None No No Not a TF - Evidence that it is not a TF___PMIDS:0 Yes 5a, one of the source datasets predicts is as a TF Tim Hughes Arttu Jolma No $#ENSG00000115750#GO:0001187#RNA polymerase I CORE element sequence-specific DNA binding transcription factor recruiting transcri#IDA - PMID:21921198, PMID:21921199$#ENSG00000115750#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:7801123 $#ENSP00000263663#ENSG00000115750#ENST00000263663#Other#zf-RRN7$#ENSP00000475608#ENSG00000115750#ENST00000492648#Other#$#ENSP00000486572#ENSG00000115750#ENST00000625239#Other#NOB1_Zn_bind, zf-RRN7 FALSE 2596 ENSG00000103168 TAF1C Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC. IPR017986 9013 TATA-box binding protein associated factor, RNA polymerase I subunit C [Source:HGNC Symbol;Acc:HGNC: None not tested not tested None None No No TF Gene_Basal Transcription Factor_TF PPI_PMIDS:7801123;9050847 No 5a, one of the source datasets predicts is as a TF Jussi Taipale Matt Weirauch No None $##ENSG00000103168##Other# FALSE 2597 ENSG00000122728 TAF1L Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None Involved in preinitiation complex assembly (general transcriptional machinery. Is a paralog of TAF1, which binds DNA based on the structure (PDB: 5FUR) IPR001487;IPR009067;IPR011177;IPR018359;IPR022591 138474 TATA-box binding protein associated factor 1 like [Source:HGNC Symbol;Acc:HGNC:18056];Transcription None not tested not tested None None No No TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:7590250 Yes 4a, two or more datasets predict it as a TF Arttu Jolma Laura Campitelli No $#ENSG00000122728#GO:0001075#RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved#IBA - GO_REF:0000033 $#ENSP00000418379#ENSG00000122728#ENST00000242310#Other#Bromodomain, DUF3591, TBP-binding, zf-CCHC_6 FALSE 2598 ENSG00000064313 TAF2 Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None Directly contact with DNA in TFIID complex (PMID: 27096372), and mediate major interactions with the downstream promoter together with TAF1. Contacts DNA in the structure (PDB: 5FUR) IPR014782;IPR016024 6873 TATA-box binding protein associated factor 2 [Source:HGNC Symbol;Acc:HGNC:11536];Transcription initi 5FUR not tested not tested None None No No TF Gene_Basal Transcription Factor_TF PPI_PMIDS:9774672 Yes 4a, two or more datasets predict it as a TF Yimeng Yin Laura Campitelli No $#ENSG00000064313#GO:0001075#RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved#IBA - GO_REF:0000033 $#ENSP00000367406#ENSG00000064313#ENST00000378164#Other#HEAT_2, Peptidase_M1$#ENSP00000430832#ENSG00000064313#ENST00000523904#Other#$#ENSP00000436750#ENSG00000064313#ENST00000529653#Other# FALSE 2599 ENSG00000165632 TAF3 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Contacts chromatin through modified histones and TFs such as TP53 (PMID: 18549481) IPR001965;IPR006565;IPR011011;IPR019786;IPR019787 83860 TATA-box binding protein associated factor 3 [Source:HGNC Symbol;Acc:HGNC:17303] None not tested not tested None None No No TF Gene_Basal Transcription Factor_TF PPI_PMIDS:11438666 Yes 4a, two or more datasets predict it as a TF Arttu Jolma Pratyush Das No $#ENSG00000165632#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:18549481 $#ENSP00000340271#ENSG00000165632#ENST00000344293#Other#Bromo_TP, Gti1_Pac2, PHD FALSE 2600 ENSG00000130699 TAF4 Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None The TAF4 domain interacts with TAF12 and makes a novel histone-like heterodimer that binds DNA and has a core promoter function for of a subset of genes (PMID: 19635797; PMID: 12237304) IPR003894;IPR007900;IPR009072 100302168 TATA-box binding protein associated factor 4 [Source:HGNC Symbol;Acc:HGNC:11537] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Matt Weirauch Sam Lambert No $#ENSG00000130699#GO:0001075#RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved#IBA - GO_REF:0000033$#ENSG00000130699#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:9603525 $#ENSP00000252996#ENSG00000130699#ENST00000252996#Other#TAF4, TAFH$#ENSP00000476270#ENSG00000130699#ENST00000474089#Other#TAF4$#ENSP00000476294#ENSG00000130699#ENST00000488539#Other#TAF4, TAFH FALSE 2601 ENSG00000141384 TAF4B Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None Histone-like protein that binds DNA as an obligate heterodimeric complex with TAF12 (PMID: 19635797). Target sequence needs to be over 70 bases long and doesnt appear to have sequence specificity IPR003894;IPR007900;IPR009072 6875 TATA-box binding protein associated factor 4b [Source:HGNC Symbol;Acc:HGNC:11538] None not tested not tested None None No No TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:11557891;16473943 No 5a, one of the source datasets predicts is as a TF Sam Lambert Arttu Jolma No $#ENSG00000141384#GO:0001075#RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved#IBA - GO_REF:0000033 $##ENSG00000141384##Other# FALSE 2602 ENSG00000148835 TAF5 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR001680;IPR006594;IPR007582;IPR017986;IPR019775;IPR020472 6877 TATA-box binding protein associated factor 5 [Source:HGNC Symbol;Acc:HGNC:11539];Transcription initi None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Yimeng Yin Jussi Taipale No $#ENSG00000148835#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:9603525 | IMP - PMID:9045704 $#ENSP00000358854#ENSG00000148835#ENST00000369839#Other#ANAPC4_WD40, Ge1_WD40, Nup160, RAB3GAP2_N, TFIID_N FALSE 2603 ENSG00000135801 TAF5L Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Paralog of TAF5 that is unlikely to contact DNA (PMID: 17227857) IPR001680;IPR007582;IPR017986;IPR019775;IPR020472 27097 TATA-box binding protein associated factor 5 like [Source:HGNC Symbol;Acc:HGNC:17304];TAF5-like RNA None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Matt Weirauch Arttu Jolma No $#ENSG00000135801#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:9674425 $#ENSP00000355635#ENSG00000135801#ENST00000366675#Other#TFIID_NTD2$#ENSP00000355636#ENSG00000135801#ENST00000366676#Other#ANAPC4_WD40, Ge1_WD40, Nup160, TFIID_NTD2, WD40, W$#ENSP00000355634#ENSG00000135801#ENST00000366674#Other#$#ENSP00000258281#ENSG00000135801#ENST00000258281#Other#ANAPC4_WD40, Ge1_WD40, Nup160, TFIID_NTD2, WD40, W FALSE 2604 ENSG00000106290 TAF6 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Does not contact DNA in the structure (PDB: 5FUR) IPR004823;IPR009072;IPR011442;IPR016024 6878 TATA-box binding protein associated factor 6 [Source:HGNC Symbol;Acc:HGNC:11540];Transcription initi 5FUR not tested not tested None None No No TF Gene_Basal Transcription Factor_TF PPI_PMIDS:7667268 Yes 4a, two or more datasets predict it as a TF Sam Lambert Yimeng Yin No $#ENSG00000106290#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:9603525$#ENSG00000106290#GO:0051090#regulation of sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002 $#ENSP00000344537#ENSG00000106290#ENST00000344095#Other#Bromo_TP, TAF, TAF6_C, TFIID-31kDa$#ENSP00000416396#ENSG00000106290#ENST00000452041#Other#Bromo_TP, TAF, TAF6_C, TFIID-31kDa$#ENSP00000389575#ENSG00000106290#ENST00000453269#Other#Bromo_TP, TAF, TAF6_C, TFIID-31kDa$#ENSP00000419760#ENSG00000106290#ENST00000472509#Other#TAF, TAF6_C, TFIID-31kDa$#ENSP00000399982#ENSG00000106290#ENST00000437822#Other#TAF, TAF6_C, TFIID-31kDa$#ENSP00000410012#ENSG00000106290#ENST00000440225#Other#Bromo_TP, Histone, TAF, TFIID-18kDa, TFIID-31kDa$#ENSP00000419555#ENSG00000106290#ENST00000493322#Other#Bromo_TP, TAF, TFIID-18kDa, TFIID-31kDa$#ENSP00000428071#ENSG00000106290#ENST00000520135#Other#TAF FALSE 2605 ENSG00000162227 TAF6L Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Part of the PCAF Histone Acetylase Complex (PMID: 9674425). Structurally similar to TAF6, which does not contact DNA directly IPR004823;IPR009072;IPR011442 10629 TATA-box binding protein associated factor 6 like [Source:HGNC Symbol;Acc:HGNC:17305] None not tested not tested None None No No TF Gene Candidate_Transcription Regulatory Activity: heterochromatin interaction/binding_TF PPI_PMIDS:9674425 No 5a, one of the source datasets predicts is as a TF Sam Lambert Pratyush Das No $#ENSG00000162227#GO:0051090#regulation of sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002 $##ENSG00000162227##Other# FALSE 2606 ENSG00000178913 TAF7 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Does not contact DNA in the structure (PDB: 5FUR) IPR006751 6879 TATA-box binding protein associated factor 7 [Source:HGNC Symbol;Acc:HGNC:11541];Transcription initi 5FUR not tested not tested None None No No TF Gene_Basal Transcription Factor_TF PPI_PMIDS:16407123 Yes 4a, two or more datasets predict it as a TF Pratyush Das Sam Lambert No $#ENSG00000178913#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:9603525 $#ENSP00000485510#ENSG00000178913#ENST00000624761#Other#TAFII55_N$#ENSP00000312709#ENSG00000178913#ENST00000313368#Other#TAFII55_N FALSE 2607 ENSG00000102387 TAF7L Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR006751 54457 TATA-box binding protein associated factor 7 like [Source:HGNC Symbol;Acc:HGNC:11548] None not tested not tested None None No No TF Gene Candidate_Basal Transcription Factor_TF PPI_PMIDS:12665565 No 5a, one of the source datasets predicts is as a TF Matt Weirauch Pratyush Das No None $##ENSG00000102387##Other# FALSE 2608 ENSG00000137413 TAF8 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Does not contact DNA in the structure (PDB: 5FUR) IPR006565;IPR009072;IPR019473 129685 TATA-box binding protein associated factor 8 [Source:HGNC Symbol;Acc:HGNC:17300] 5FUR not tested not tested None None No No TF Gene Candidate_Basal Transcription Factor_Transactivation_PMIDS:14580349;15870280 No 5a, one of the source datasets predicts is as a TF Jussi Taipale Arttu Jolma No None $##ENSG00000137413##Other# FALSE 2609 ENSG00000273841 TAF9 Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None Related to histone H3. (PMID: 15601843) shows DNA binding activity in complex with TAF4b, but does not demonstrate intrinsic sequence specificity. May contact promoter DNA (PMID: 23292512) IPR003162;IPR009072 6880 TATA-box binding protein associated factor 9 [Source:HGNC Symbol;Acc:HGNC:11542] None not tested not tested None None No No TF Gene_Basal Transcription Factor_TF PPI_PMIDS:7597030;7761466 No 5a, one of the source datasets predicts is as a TF Arttu Jolma Pratyush Das No None $##ENSG00000273841##Other# FALSE 2610 ENSG00000187325 TAF9B Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR003162;IPR009072 51616 TATA-box binding protein associated factor 9b [Source:HGNC Symbol;Acc:HGNC:17306] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Sam Lambert Pratyush Das No $#ENSG00000187325#GO:0001075#RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved#IBA - GO_REF:0000033 $#ENSP00000339917#ENSG00000187325#ENST00000341864#Other#Bromo_TP, CENP-S, TFIID-31kDa FALSE 2611 ENSG00000120948 TARDBP Unknown No ssDNA/RNA binding Not a DNA binding protein No motif None Is an RNA-binding protein that can also bind single stranded DNA, as in the structure (PDB: 3D2W) IPR000504 23435 TAR DNA binding protein [Source:HGNC Symbol;Acc:HGNC:11571] 3D2W not tested not tested None None No No Not a TF - Evidence that it is not a TF___PMIDS:0 Yes 3a, decent circumstantial evidence for its role as Arttu Jolma Yimeng Yin No $#ENSG00000120948#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:7745706 $#ENSP00000240185#ENSG00000120948#ENST00000240185#Other#$#ENSP00000465240#ENSG00000120948#ENST00000473118#Other#$#ENSP00000480690#ENSG00000120948#ENST00000621715#Other# FALSE 2612 ENSG00000106052 TAX1BP1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR012852; 8887 Tax1 binding protein 1 [Source:HGNC Symbol;Acc:HGNC:11575] None not tested not tested None None c No No Yes 4a, two or more datasets predict it as a TF Laura Campitelli Jussi Taipale No $#ENSG00000106052#GO:0032088#negative regulation of NF-kappaB transcription factor activity#ISS - GO_REF:0000024 $#ENSP00000265393#ENSG00000106052#ENST00000265393#Other#CALCOCO1$#ENSP00000379612#ENSG00000106052#ENST00000396319#Other#CALCOCO1$#ENSP00000391907#ENSG00000106052#ENST00000433216#Other#CALCOCO1, zf-C2H2_4$#ENSP00000444811#ENSG00000106052#ENST00000543117#Other#CALCOCO1$#ENSP00000395290#ENSG00000106052#ENST00000422800#Other#CALCOCO1 FALSE 2613 ENSG00000092377 TBL1Y Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None No DBD. Included as a candidate only because TFcat lists it as a putative coactivator. IPR001680;IPR006594;IPR017986;IPR019775;IPR020472 90665 transducin (beta)-like 1, Y-linked [Source:HGNC Symbol;Acc:HGNC:18502] None not tested not tested None None No No TF Gene Candidate__Co-activation_PMIDS:12628926 No 5a, one of the source datasets predicts is as a TF Tim Hughes Laura Campitelli No None $##ENSG00000092377##Other# FALSE 2614 ENSG00000171703 TCEA2 Unknown No ssDNA/RNA binding Not a DNA binding protein No motif None Likely binds RNA based on similarity to TCEA1 IPR001222;IPR003617;IPR003618;IPR006289;IPR016492;IPR017890;IPR017923 6919 transcription elongation factor A2 [Source:HGNC Symbol;Acc:HGNC:11614] None not tested not tested None None No No TF Gene_Transcription Factor Binding: tf co-factor binding; Basal Transcription Factor_TF PPI_PMIDS:9305922;15507123 No 5a, one of the source datasets predicts is as a TF Arttu Jolma Yimeng Yin No None $##ENSG00000171703##Other# FALSE 2615 ENSG00000172465 TCEAL1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR021156 9338 Transcription elongation factor A protein-like 1 None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Sam Lambert Arttu Jolma No $#ENSG00000172465#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:7971997 $#ENSP00000361707#ENSG00000172465#ENST00000372624#Other#BEX$#ENSP00000361708#ENSG00000172465#ENST00000372625#Other#BEX$#ENSP00000361709#ENSG00000172465#ENST00000372626#Other#BEX FALSE 2616 ENSG00000182916 TCEAL7 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Modulates transcription, but there is no evidence for DNA binding (PMID: 19966855) IPR021156 56849 transcription elongation factor A like 7 [Source:HGNC Symbol;Acc:HGNC:28336] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Jussi Taipale Sam Lambert No $#ENSG00000182916#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IDA - PMID:19966855 $#ENSP00000329794#ENSG00000182916#ENST00000332431#Other#BEX$#ENSP00000361751#ENSG00000182916#ENST00000372666#Other#BEX FALSE 2617 ENSG00000180964 TCEAL8 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Lacks a canonical DBD IPR021156; 90843 transcription elongation factor A like 8 [Source:HGNC Symbol;Acc:HGNC:28683] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Pratyush Das Sam Lambert No None $#ENSP00000353093#ENSG00000180964#ENST00000360000#Other#BEX$#ENSP00000361770#ENSG00000180964#ENST00000372685#Other#BEX$#ENSP00000390880#ENSG00000180964#ENST00000451678#Other#BEX FALSE 2618 ENSG00000137310 TCF19 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif Has a putative AT-hook Previous evidence (PMID: 1868030) for TF activity is based on sequence analysis (high proline content), and presence of an FHA domain. However, neither prove ability to bind DNA in a sequence-specific manner IPR000253;IPR001965;IPR008984;IPR011011;IPR019786;IPR019787 6941 transcription factor 19 [Source:HGNC Symbol;Acc:HGNC:11629] None not tested not tested None None other No No No 5a, one of the source datasets predicts is as a TF Sam Lambert Jussi Taipale No $#ENSG00000137310#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:1868030 $#ENSP00000365431#ENSG00000137310#ENST00000376255#Other#FHA, PHD$#ENSP00000365433#ENSG00000137310#ENST00000376257#Other#FHA, PHD$#ENSP00000439397#ENSG00000137310#ENST00000542218#Other# FALSE 2619 ENSG00000100207 TCF20 Unknown Yes Likely to be sequence specific TF Monomer or homomultimer No motif None (PMID: 7760812) identified this protein in a library screen and demonstrated DNA binding of an IVT product to an enhancer of interest. They also identified a putative bZIP domain that is not detected by Pfam or SMART. (PMID:10995766) subsequently mapped the strongest DNA binding site. IPR001965; 6942 transcription factor 20 (AR1) [Source:HGNC Symbol;Acc:HGNC:11631] None not tested not tested None None other No TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:7760812;10849425;10995766 Yes 4a, two or more datasets predict it as a TF Laura Campitelli Tim Hughes No $#ENSG00000100207#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000335561#ENSG00000100207#ENST00000335626#Other#zf-HC5HC2H, zf-HC5HC2H_2$#ENSP00000352463#ENSG00000100207#ENST00000359486#Other#zf-HC5HC2H, zf-HC5HC2H_2$#ENSP00000385531#ENSG00000100207#ENST00000404876#Other#zf-HC5HC2H, zf-HC5HC2H_2$#ENSP00000458948#ENSG00000100207#ENST00000515426#Other# FALSE 2620 ENSG00000141002 TCF25 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Only evidence is based on (PMID:16574069), which claims that hnulp1 (TCF25) contains a possible bHLH domain and that it represses transcription in a Gal4-forced recruitment assay. IPR006994; 22980 transcription factor 25 [Source:HGNC Symbol;Acc:HGNC:29181] None not tested not tested None None other No No Yes 4a, two or more datasets predict it as a TF Sam Lambert Laura Campitelli Yes $#ENSG00000141002#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:16574069 $#ENSP00000263346#ENSG00000141002#ENST00000263346#Other#Tcf25$#ENSP00000455611#ENSG00000141002#ENST00000562256#Other#Tcf25$#ENSP00000456592#ENSG00000141002#ENST00000565404#Other#$#ENSP00000455471#ENSG00000141002#ENST00000566283#Other#$#ENSP00000456803#ENSG00000141002#ENST00000561958#Other#DUF4604$#ENSP00000456344#ENSG00000141002#ENST00000562193#Other#Tcf25$#ENSP00000456840#ENSG00000141002#ENST00000568409#Other#Tcf25$#ENSP00000457329#ENSG00000141002#ENST00000568412#Other#DUF4604, Tcf25 FALSE 2621 ENSG00000139372 TDG Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None TDG is specific for G/T mispairs in DNA (PDB: 2RBA; PMID: 18587051). Some evidence exists for TDG affecting transcription through interactions with NHR TFs (PMID: 9694815), suggesting it could also be a transcriptional co-factor IPR003310;IPR005122 6996 thymine DNA glycosylase [Source:HGNC Symbol;Acc:HGNC:11700] 2RBA not tested not tested None DNA error reparing enzyme Human thymine DNA glycosylase (hTDG) removes T from G.T mispairs, producing an abasic (or AP) site No No TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:9694815 No 5a, one of the source datasets predicts is as a TF Sam Lambert Pratyush Das No None $##ENSG00000139372##Other# FALSE 2622 ENSG00000042088 TDP1 Unknown No ssDNA/RNA binding Not a DNA binding protein No motif None Binds single stranded DNA in the structure (PDB: 1NOP) None 55775 tyrosyl-DNA phosphodiesterase 1 1NOP not tested not tested None None No No No No New proteins added based on PDB entry Arttu Jolma Sam Lambert No None None FALSE 2623 ENSG00000111802 TDP2 Unknown No ssDNA/RNA binding Not a DNA binding protein No motif None Binds single stranded DNA in the structure (PDB: 4F1H) None 51567 tyrosyl-DNA phosphodiesterase 2 4F1H not tested not tested None None No No No No New proteins added based on PDB entry Arttu Jolma Sam Lambert No None None FALSE 2624 ENSG00000168769 TET2 Unknown Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Binds DNA in the crystal structure (PDB: 4NM6). Oxidizes 5-methylcytosine (5mC). None 54790 tet methylcytosine dioxygenase 2 4NM6 not tested not tested None None No No No No New proteins added based on PDB entry Arttu Jolma Sam Lambert No None None FALSE 2625 ENSG00000105329 TGFB1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None None 7040 Transforming growth factor beta-1 None not tested not tested None None No No Not a TF - Evidence that it is not a TF___PMIDS:0 Yes 5a, one of the source datasets predicts is as a TF Jussi Taipale Pratyush Das No $#ENSG00000105329#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IEA - GO_REF:0000019 $##ENSG00000105329##Other# FALSE 2626 ENSG00000140682 TGFB1I1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Available evidence suggests that it acts as a co-factor IPR001781;IPR017305 7041 transforming growth factor beta 1 induced transcript 1 [Source:HGNC Symbol;Acc:HGNC:11767] None not tested not tested None None No No TF Gene_Transcription Factor Binding: tf co-factor binding; DNA-Binding: sequence-specific_DNA Binding_PMIDS:9722648;14755691 No 5a, one of the source datasets predicts is as a TF Jussi Taipale Yimeng Yin No None $##ENSG00000140682##Other# FALSE 2627 ENSG00000137574 TGS1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Protein is an RNA-modifying enzyme (PMID: 19307714) IPR019012;IPR029063 96764 trimethylguanosine synthase 1 [Source:HGNC Symbol;Acc:HGNC:17843] None not tested not tested None None No No TF Gene Candidate_Transcription Regulatory Activity: heterochromatin interaction/binding_Other_PMIDS:11517327;11912212 No 5a, one of the source datasets predicts is as a TF Arttu Jolma Yimeng Yin No None $##ENSG00000137574##Other# FALSE 2628 ENSG00000054118 THRAP3 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR029199 9967 thyroid hormone receptor associated protein 3 [Source:HGNC Symbol;Acc:HGNC:22964] None not tested not tested None None No No TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_Transactivation_PMIDS:8710870;10198638 No 5a, one of the source datasets predicts is as a TF Matt Weirauch Jussi Taipale No None $##ENSG00000054118##Other# FALSE 2629 ENSG00000151500 THYN1 Unknown Yes Likely to be sequence specific TF Low specificity DNA-binding protein No motif None Binds DNA in the crystal structure (PDB: 5J3E). Recognizes 5mC containing DNA. Contacts the DNA backbone from the side of the minor groove and has an arginine that inserts into the minor groove. None 29087 thymocyte nuclear protein 1 5J3E not tested not tested None None No No No No New proteins added based on PDB entry None None No None None FALSE 2630 ENSG00000116001 TIA1 Unknown No ssDNA/RNA binding Not a DNA binding protein No motif None Has an RRM domain. Binds single stranded DNA in the structure (PDB: 5ITH) None 7072 TIA1 cytotoxic granule-associated RNA binding protein 5ITH not tested not tested None None No No No No New proteins added based on PDB entry Arttu Jolma Sam Lambert No None None FALSE 2631 ENSG00000127666 TICAM1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None None 148022 TIR domain-containing adapter molecule 1 None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Sam Lambert Matt Weirauch No $#ENSG00000127666#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IEA - GO_REF:0000019 $##ENSG00000127666##Other# FALSE 2632 ENSG00000163659 TIPARP Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000571;IPR004170;IPR012317; 25976 TCDD inducible poly(ADP-ribose) polymerase [Source:HGNC Symbol;Acc:HGNC:23696] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Matt Weirauch Arttu Jolma No None $#ENSP00000295924#ENSG00000163659#ENST00000295924#Other#PARP, WWE$#ENSP00000420612#ENSG00000163659#ENST00000461166#Other#PARP, WWE$#ENSP00000418829#ENSG00000163659#ENST00000481853#Other#PARP, WWE$#ENSP00000420141#ENSG00000163659#ENST00000495891#Other#PARP, WWE$#ENSP00000438345#ENSG00000163659#ENST00000542783#Other#PARP, WWE$#ENSP00000419982#ENSG00000163659#ENST00000473702#Other#WWE FALSE 2633 ENSG00000150455 TIRAP Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000157;IPR017279 114609 toll-interleukin 1 receptor (TIR) domain containing adaptor protein [Source:HGNC Symbol;Acc:HGNC:171 None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Jussi Taipale Matt Weirauch No $#ENSG00000150455#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IMP - PMID:19509286 $#ENSP00000376445#ENSG00000150455#ENST00000392678#Other#TIR, TIR_2$#ENSP00000376447#ENSG00000150455#ENST00000392680#Other#TIR, TIR_2$#ENSP00000376446#ENSG00000150455#ENST00000392679#Other#TIR, TIR_2 FALSE 2634 ENSG00000196781 TLE1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Transcriptional co-factor IPR001680;IPR005617;IPR009146;IPR017986;IPR019775 7088 transducin like enhancer of split 1 [Source:HGNC Symbol;Acc:HGNC:11837] None not tested not tested None None No No TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:9837750 No 5a, one of the source datasets predicts is as a TF Sam Lambert Pratyush Das No None $##ENSG00000196781##Other# FALSE 2635 ENSG00000065717 TLE2 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR001680;IPR005617;IPR009146;IPR017986;IPR019775 7089 transducin like enhancer of split 2 [Source:HGNC Symbol;Acc:HGNC:11838] None not tested not tested None None No No TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_TF PPI; Transactivation_PMIDS:9874198 No 5a, one of the source datasets predicts is as a TF Matt Weirauch Yimeng Yin No None $##ENSG00000065717##Other# FALSE 2636 ENSG00000140332 TLE3 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif Has a putative AT-hook Protein is a transcriptional co-regulator (PMID: 21459326) IPR001680;IPR005617;IPR009146;IPR017986;IPR019775 7090 transducin like enhancer of split 3 [Source:HGNC Symbol;Acc:HGNC:11839] None not tested not tested None None No No TF Gene Candidate__Co-activation_PMIDS:11266540 No 5a, one of the source datasets predicts is as a TF Laura Campitelli Arttu Jolma No None $##ENSG00000140332##Other# FALSE 2637 ENSG00000106829 TLE4 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None TLE4 is a Groucho protein (co-repressor) IPR001680;IPR005617;IPR009146;IPR017986;IPR019775 7091 transducin like enhancer of split 4 [Source:HGNC Symbol;Acc:HGNC:11840] None not tested not tested None None No No TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:12153506 No 5a, one of the source datasets predicts is as a TF Sam Lambert Yimeng Yin No $#ENSG00000106829#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019 $##ENSG00000106829##Other# FALSE 2638 ENSG00000104953 TLE6 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Transcriptional cofactor that associates with FOXG1 (PMID: 16314515) IPR001680;IPR009146;IPR017986 79816 transducin like enhancer of split 6 [Source:HGNC Symbol;Acc:HGNC:30788] None not tested not tested None None No No TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:16314515 No 5a, one of the source datasets predicts is as a TF Matt Weirauch Arttu Jolma No None $##ENSG00000104953##Other# FALSE 2639 ENSG00000137462 TLR2 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Upstream of NFKB and not involved in DNA-binding IPR000157;IPR000483;IPR001611;IPR003591;IPR017241 7097 toll like receptor 2 [Source:HGNC Symbol;Acc:HGNC:11848] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Sam Lambert Pratyush Das No $#ENSG00000137462#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IDA - PMID:12594207, PMID:21618349 $#ENSP00000260010#ENSG00000137462#ENST00000260010#Other#LRRCT, LRR_1, LRR_4, LRR_5, LRR_8, LRR_9, TIR, TIR FALSE 2640 ENSG00000164342 TLR3 Unknown No ssDNA/RNA binding Not a DNA binding protein No motif None Binds dsRNA (PMID: 16111635) None 7098 Toll-like receptor 3 None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Laura Campitelli Pratyush Das No $#ENSG00000164342#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IEA - GO_REF:0000019 $##ENSG00000164342##Other# FALSE 2641 ENSG00000136869 TLR4 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000157;IPR000483;IPR001611;IPR003591;IPR017241;IPR025875 7099 toll like receptor 4 [Source:HGNC Symbol;Acc:HGNC:11850] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Jussi Taipale Matt Weirauch No $#ENSG00000136869#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IDA - PMID:12594207 $#ENSP00000363089#ENSG00000136869#ENST00000355622#Other#DUF1863, LRR_1, LRR_4, LRR_6, LRR_8, LRR_9, TIR, T$#ENSP00000377997#ENSG00000136869#ENST00000394487#Other#DUF1863, LRR_1, LRR_4, LRR_6, LRR_8, LRR_9, TIR, T FALSE 2642 ENSG00000239732 TLR9 Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None Protein is a nonmethylated CpG dsDNA recognizing protein that operates in the innate immune response to pathogen invasion of the cell. It isnt a TF, but it binds pathogenic DNA (PMID: 11564765). Binds single-stranded DNA in the structure (PDB: 3WPC) IPR000157;IPR001611;IPR003591 54106 toll like receptor 9 [Source:HGNC Symbol;Acc:HGNC:15633] 3WPC not tested not tested None None No No No Yes 3a, decent circumstantial evidence for its role as Arttu Jolma Laura Campitelli No $#ENSG00000239732#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IDA - PMID:17128265$#ENSG00000239732#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IDA - PMID:17128265 $#ENSP00000353874#ENSG00000239732#ENST00000360658#Other#LRR_1, LRR_4, LRR_5, LRR_6, LRR_8, LRR_9, TIR FALSE 2643 ENSG00000204278 TMEM235 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Transmembrane protein IPR004031;IPR006187 283999 transmembrane protein 235 [Source:HGNC Symbol;Acc:HGNC:27563] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Laura Campitelli Arttu Jolma No None $#ENSP00000466793#ENSG00000204278#ENST00000586400#Other#Claudin_2, PMP22_Claudin$#ENSP00000447766#ENSG00000204278#ENST00000550981#Other#Claudin_2, PMP22_Claudin FALSE 2644 ENSG00000144747 TMF1 Unknown Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Bacterially-expressed protein binds specifically to the TATA element to compete with TBP, based on EMSA (PMID: 1409643) IPR022091;IPR022092 7110 TATA element modulatory factor 1 [Source:HGNC Symbol;Acc:HGNC:11870] None not tested not tested None None No No TF Gene_Transcription Factor Binding: tf co-factor binding_DNA Binding_PMIDS:1409643;10428808 No 5a, one of the source datasets predicts is as a TF Arttu Jolma Sam Lambert No None $##ENSG00000144747##Other# FALSE 2645 ENSG00000232810 TNF Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None The protein is a secreted cytokine and operates far upstream in the signaling cascade IPR002959;IPR006052;IPR006053;IPR008983;IPR021184 7124 tumor necrosis factor [Source:HGNC Symbol;Acc:HGNC:11892] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Arttu Jolma Pratyush Das No None None FALSE 2646 ENSG00000118503 TNFAIP3 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Inhibits NFKB-activation. No evidence for direct binding to DNA IPR002653;IPR003323 7128 TNF alpha induced protein 3 [Source:HGNC Symbol;Acc:HGNC:11896] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Arttu Jolma Jussi Taipale No $#ENSG00000118503#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IDA - PMID:18223652 $#ENSP00000237289#ENSG00000118503#ENST00000237289#Other#OTU, zf-A20$#ENSP00000393577#ENSG00000118503#ENST00000421450#Other#$#ENSP00000401562#ENSG00000118503#ENST00000420009#Other#OTU$#ENSP00000409845#ENSG00000118503#ENST00000433680#Other# FALSE 2647 ENSG00000141655 TNFRSF11A Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR001368;IPR022323;IPR022361 8792 tumor necrosis factor receptor superfamily member 11a [Source:HGNC Symbol;Acc:HGNC:11908] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Yimeng Yin Sam Lambert No $#ENSG00000141655#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:12296995 | ISS - PMID:19940926$#ENSG00000141655#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IDA - PMID:9367155 | IMP - PMID:12296995 $#ENSP00000269485#ENSG00000141655#ENST00000269485#Other#TNFR_c6$#ENSP00000465500#ENSG00000141655#ENST00000586569#Other#TNFR_c6$#ENSP00000479567#ENSG00000141655#ENST00000616710#Other#DAG1, TNFR_c6$#ENSP00000482466#ENSG00000141655#ENST00000617039#Other#DAG1, TNFR_c6 FALSE 2648 ENSG00000186827 TNFRSF4 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Operates far upstream in the signaling cascade IPR001368;IPR020445 7293 tumor necrosis factor receptor superfamily member 4 [Source:HGNC Symbol;Acc:HGNC:11918] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Laura Campitelli Arttu Jolma No $#ENSG00000186827#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024 $#ENSP00000368538#ENSG00000186827#ENST00000379236#Other#TNFR_c6 FALSE 2649 ENSG00000120659 TNFSF11 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR006052;IPR008983;IPR017355 8600 tumor necrosis factor superfamily member 11 [Source:HGNC Symbol;Acc:HGNC:11926] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Sam Lambert Yimeng Yin No $#ENSG00000120659#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#ISS - PMID:19940926$#ENSG00000120659#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IDA - PMID:9367155 $#ENSP00000351347#ENSG00000120659#ENST00000358545#Other#TNF$#ENSP00000381775#ENSG00000120659#ENST00000398795#Other#TNF$#ENSP00000444913#ENSG00000120659#ENST00000544862#Other#TNF FALSE 2650 ENSG00000120337 TNFSF18 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Protein is a cytokine IPR006052;IPR008983 8995 tumor necrosis factor superfamily member 18 [Source:HGNC Symbol;Acc:HGNC:11932] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Pratyush Das Arttu Jolma No $#ENSG00000120337#GO:0051092#positive regulation of NF-kappaB transcription factor activity#ISS - GO_REF:0000024 $#ENSP00000385470#ENSG00000120337#ENST00000404377#Other#TNF FALSE 2651 ENSG00000117586 TNFSF4 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Extracellular signaling molecule. Included only because it regulates TFs. IPR006052;IPR008983;IPR021184 7292 tumor necrosis factor superfamily member 4 [Source:HGNC Symbol;Acc:HGNC:11934] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Sam Lambert Tim Hughes No $#ENSG00000117586#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024 $#ENSP00000281834#ENSG00000117586#ENST00000281834#Other#$#ENSP00000356691#ENSG00000117586#ENST00000367718#Other# FALSE 2652 ENSG00000160949 TONSL Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None Binds to the N-terminal tail of Histone H4 (PMID: 27338793, PDB: 5JA4). It is likely a histone chaperone (PMID: 26527279) and thus probably forms nonspecific contacts with DNA. None 4796 Tonsoku like, DNA repair protein 5JA4 not tested not tested None None No No No No New proteins added based on PDB entry Arttu Jolma Sam Lambert No None None FALSE 2653 ENSG00000198900 TOP1 Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None DNA topoisomerase. Binds DNA in the crystal structure (PDB: 1A31). None 7150 topoisomerase (DNA) I 1A31 not tested not tested None None No No No No New proteins added based on PDB entry Arttu Jolma Sam Lambert No None None FALSE 2654 ENSG00000131747 TOP2A Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None DNA topoisomerase. Binds DNA in the crystal structure (PDB: 4FM9). None 7153 topoisomerase (DNA) II alpha 4FM9 not tested not tested None None No No No No New proteins added based on PDB entry Arttu Jolma Sam Lambert No None None FALSE 2655 ENSG00000077097 TOP2B Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None DNA topoisomerase. Binds DNA in the crystal structure (PDB: 3QX3). None 7155 topoisomerase (DNA) II beta 3QX3 not tested not tested None None No No No No New proteins added based on PDB entry Arttu Jolma Sam Lambert No None None FALSE 2656 ENSG00000197579 TOPORS Unknown Yes Known motif Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain None IPR001841;IPR017907;IPR018957 10210 TOP1 binding arginine/serine rich protein [Source:HGNC Symbol;Acc:HGNC:21653] None not tested not tested None None No Yes TF Gene_Single stranded RNA/DNA binding_DNA Binding_PMIDS:11278651;15735665 No 2a1, Lower confidence direct evidence Pratyush Das Sam Lambert No None $#ENSP00000353735#ENSG00000197579#ENST00000360538#Other#Prok-RING_4, zf-ANAPC11, zf-C3HC4, zf-C3HC4_2, zf-$#ENSP00000369187#ENSG00000197579#ENST00000379858#Other#Prok-RING_4, zf-ANAPC11, zf-C3HC4, zf-C3HC4_2, zf- FALSE 2657 ENSG00000067369 TP53BP1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif Has a putative AT-hook Structure PDB:5KGF has just a fragment of TP53BP1 that doesnt contact DNA, but histones IPR001357;IPR015125 7158 tumor protein p53 binding protein 1 [Source:HGNC Symbol;Acc:HGNC:11999] 5KGF not tested not tested None None No No No Yes 3a, decent circumstantial evidence for its role as Pratyush Das Yimeng Yin No $#ENSG00000067369#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IC - PMID:17805299 $#ENSP00000263801#ENSG00000067369#ENST00000263801#Other#53-BP1_Tudor, BRCT, BRCT_2, RTT107_BRCT_5$#ENSP00000371475#ENSG00000067369#ENST00000382044#Other#53-BP1_Tudor, BRCT, BRCT_2, RTT107_BRCT_5$#ENSP00000393497#ENSG00000067369#ENST00000450115#Other#53-BP1_Tudor, BRCT, BRCT_2, RTT107_BRCT_5$#ENSP00000416212#ENSG00000067369#ENST00000434595#Other#$#ENSP00000471624#ENSG00000067369#ENST00000467474#Other# FALSE 2658 ENSG00000102871 TRADD Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Regulates transcription by binding to the adaptor protein TRAF2, leading to reduction of recruitment of inhibitor-of-apoptosis proteins. No evidence for binding DNA (PMID: 18309324) IPR000488;IPR009095;IPR011029 8717 TNFRSF1A associated via death domain [Source:HGNC Symbol;Acc:HGNC:12030];Tumor necrosis factor recep None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Arttu Jolma Tim Hughes No $#ENSG00000102871#GO:0051092#positive regulation of NF-kappaB transcription factor activity#TAS - PMID:18309324 $#ENSP00000341268#ENSG00000102871#ENST00000345057#Other#Death, TRADD_N$#ENSP00000462591#ENSG00000102871#ENST00000486556#Other#Death, TRADD_N FALSE 2659 ENSG00000056558 TRAF1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None TRAF1 is an NF-kappaB interactor (PMID: 10692572), and is unlikely to have DNA-binding activity IPR002083;IPR008974;IPR012227 7185 TNF receptor associated factor 1 [Source:HGNC Symbol;Acc:HGNC:12031] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Sam Lambert Yimeng Yin No $#ENSG00000056558#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IDA - PMID:10692572 $#ENSP00000362994#ENSG00000056558#ENST00000373887#Other#TRAF_BIRC3_bd$#ENSP00000443183#ENSG00000056558#ENST00000540010#Other#TRAF_BIRC3_bd$#ENSP00000438583#ENSG00000056558#ENST00000546084#Other#TRAF_BIRC3_bd FALSE 2660 ENSG00000127191 TRAF2 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Does not contain any canonical DBDs IPR001293;IPR001841;IPR002083;IPR008974;IPR012227;IPR017907;IPR018957 7186 TNF receptor associated factor 2 [Source:HGNC Symbol;Acc:HGNC:12032] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Sam Lambert Matt Weirauch No $#ENSG00000127191#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IMP - PMID:12296995$#ENSG00000127191#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IDA - PMID:11279055 | IMP - PMID:12296995, PMID:15 $#ENSP00000247668#ENSG00000127191#ENST00000247668#Other#MATH, Reo_sigmaC, TRAF_BIRC3_bd, zf-C3HC4, zf-C3HC$#ENSP00000397653#ENSG00000127191#ENST00000414589#Other#zf-C3HC4, zf-C3HC4_2, zf-C3HC4_3, zf-C3HC4_4, zf-R$#ENSP00000405860#ENSG00000127191#ENST00000419057#Other#zf-C3HC4, zf-C3HC4_2, zf-C3HC4_4, zf-RING_6$#ENSP00000406524#ENSG00000127191#ENST00000429509#Other#zf-C3HC4, zf-C3HC4_2, zf-C3HC4_4, zf-RING_2, zf-RI FALSE 2661 ENSG00000131323 TRAF3 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR001293;IPR001841;IPR002083;IPR008974;IPR012227;IPR017907;IPR018957 7187 TNF receptor associated factor 3 [Source:HGNC Symbol;Acc:HGNC:12033] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Matt Weirauch Laura Campitelli No $#ENSG00000131323#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IMP - PMID:20185819 $#ENSP00000332468#ENSG00000131323#ENST00000351691#Other#Fib_alpha, MPS2, Spc7, zf-C3HC4, zf-TRAF$#ENSP00000376500#ENSG00000131323#ENST00000392745#Other#DUF812, MPS2, Spc7, zf-C3HC4, zf-TRAF$#ENSP00000454207#ENSG00000131323#ENST00000560371#Other#DUF812, MPS2, Spc7, zf-C3HC4, zf-TRAF$#ENSP00000445998#ENSG00000131323#ENST00000539721#Other#MPS2, zf-C3HC4, zf-TRAF$#ENSP00000453032#ENSG00000131323#ENST00000559734#Other#ATG16, FliJ, MPS2, Spc29, Spc7, Tropomyosin_1, zf-$#ENSP00000453623#ENSG00000131323#ENST00000560463#Other#zf-C3HC4, zf-C3HC4_2, zf-C3HC4_3, zf-C3HC4_4, zf-H FALSE 2662 ENSG00000076604 TRAF4 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Operates far upstream in the signaling cascade IPR001293;IPR001841;IPR002083;IPR008974;IPR012227;IPR017907;IPR018957 9618 TNF receptor associated factor 4 [Source:HGNC Symbol;Acc:HGNC:12034] None not tested not tested None None No No TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:16157600;16157600 No 5a, one of the source datasets predicts is as a TF Matt Weirauch Arttu Jolma No None $##ENSG00000076604##Other# FALSE 2663 ENSG00000082512 TRAF5 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Operates far upstream in the signaling cascade IPR001293;IPR001841;IPR002083;IPR008974;IPR012227;IPR017907;IPR018957 7188 TNF receptor associated factor 5 [Source:HGNC Symbol;Acc:HGNC:12035] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Jussi Taipale Arttu Jolma No $#ENSG00000082512#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IMP - PMID:12296995$#ENSG00000082512#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IMP - PMID:12296995, PMID:15121867 $#ENSP00000261464#ENSG00000082512#ENST00000261464#Other#ATG16, Sina, Spc29, zf-C3HC4, zf-C3HC4_2, zf-C3HC4$#ENSP00000355971#ENSG00000082512#ENST00000367004#Other#ATG16, Sina, Spc29, zf-C3HC4, zf-C3HC4_2, zf-C3HC4$#ENSP00000336825#ENSG00000082512#ENST00000336184#Other#ATG16, Sina, Spc29, zf-C3HC4, zf-C3HC4_2, zf-C3HC4 FALSE 2664 ENSG00000175104 TRAF6 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR001293;IPR001841;IPR002083;IPR008974;IPR012227;IPR017907 7189 TNF receptor associated factor 6 [Source:HGNC Symbol;Acc:HGNC:12036] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Jussi Taipale Pratyush Das No $#ENSG00000175104#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IMP - PMID:12296995$#ENSG00000175104#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IDA - PMID:11279055, PMID:11751921, PMID:16378096 $#ENSP00000337853#ENSG00000175104#ENST00000348124#Other#SlyX, Tropomyosin_1, U-box, zf-C3HC4, zf-C3HC4_2, $#ENSP00000433623#ENSG00000175104#ENST00000526995#Other#SlyX, Tropomyosin_1, U-box, zf-C3HC4, zf-C3HC4_2, FALSE 2665 ENSG00000167632 TRAPPC9 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None None 83696 Trafficking protein particle complex subunit 9 None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Pratyush Das Laura Campitelli No $#ENSG00000167632#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IEA - GO_REF:0000019 $##ENSG00000167632##Other# FALSE 2666 ENSG00000213689 TREX1 Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None Has weak exonuclease activity for GAG, ACA, and CTGC DNA sequences (PMID: 17355961) None 11277 three prime repair exonuclease 1 2O4I not tested not tested None None No No No No New proteins added based on PDB entry Arttu Jolma Sam Lambert No None None FALSE 2667 ENSG00000173334 TRIB1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Associates with CEBPB and CEBPA and inhibits their activities (PMID: 17724128). This is probably achieved through control of their proteosomal degradation (PMID: 17576771) IPR000719;IPR002290;IPR011009 10221 tribbles pseudokinase 1 [Source:HGNC Symbol;Acc:HGNC:16891] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Arttu Jolma Sam Lambert No $#ENSG00000173334#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#IMP - PMID:15299019 | ISS - PMID:17724128 $#ENSP00000312150#ENSG00000173334#ENST00000311922#Other#Kinase-like, Pkinase, Pkinase_Tyr$#ENSP00000428879#ENSG00000173334#ENST00000519576#Other#Pkinase, Pkinase_Tyr$#ENSP00000429063#ENSG00000173334#ENST00000520847#Other#Kinase-like, Pkinase, Pkinase_Tyr FALSE 2668 ENSG00000101255 TRIB3 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Disabled kinase - binds NFkappaB and ATF4, but no evidence for direct sequence specific DNA binding. IPR000719;IPR002290;IPR011009 57761 tribbles pseudokinase 3 [Source:HGNC Symbol;Acc:HGNC:16228] None not tested not tested None None No No TF Evidence Conflict - There is evidence for and against this genes role as a TF__Other_PMIDS:12749859 No 5a, one of the source datasets predicts is as a TF Jussi Taipale Tim Hughes No None $##ENSG00000101255##Other# FALSE 2669 ENSG00000204977 TRIM13 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Operates far upstream in the signaling cascade. Ring fingers usually operate in protein-protein interactions IPR000315;IPR001841;IPR017907;IPR018957 10206 tripartite motif containing 13 [Source:HGNC Symbol;Acc:HGNC:9976] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Laura Campitelli Arttu Jolma No $#ENSG00000204977#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IMP - PMID:23077300 $#ENSP00000348299#ENSG00000204977#ENST00000356017#Other#zf-B_box, zf-C3HC4, zf-C3HC4_2, zf-C3HC4_3, zf-C3H$#ENSP00000367424#ENSG00000204977#ENST00000378182#Other#zf-B_box, zf-C3HC4, zf-C3HC4_2, zf-C3HC4_3, zf-C3H$#ENSP00000412943#ENSG00000204977#ENST00000420995#Other#zf-B_box, zf-C3HC4, zf-C3HC4_2, zf-C3HC4_3, zf-C3H$#ENSP00000399206#ENSG00000204977#ENST00000457662#Other#zf-B_box, zf-C3HC4, zf-C3HC4_2, zf-C3HC4_3, zf-C3H$#ENSP00000367425#ENSG00000204977#ENST00000378183#Other#zf-B_box, zf-C3HC4, zf-C3HC4_2, zf-C3HC4_3, zf-C3H FALSE 2670 ENSG00000106785 TRIM14 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000315;IPR001870;IPR003877;IPR003879;IPR006574;IPR013320 9830 tripartite motif containing 14 [Source:HGNC Symbol;Acc:HGNC:16283] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Laura Campitelli Yimeng Yin No $#ENSG00000106785#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:23077300$#ENSG00000106785#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IDA - PMID:23077300 $#ENSP00000344208#ENSG00000106785#ENST00000341469#Other#PRY, SPRY, zf-B_box$#ENSP00000343990#ENSG00000106785#ENST00000342043#Other#PRY, SPRY, zf-B_box$#ENSP00000364239#ENSG00000106785#ENST00000375098#Other#PRY, SPRY, zf-B_box FALSE 2671 ENSG00000204610 TRIM15 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000315;IPR001841;IPR001870;IPR003877;IPR003879;IPR006574;IPR013320;IPR017907;IPR018957 89870 tripartite motif containing 15 [Source:HGNC Symbol;Acc:HGNC:16284] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Yimeng Yin Pratyush Das No None None FALSE 2672 ENSG00000132109 TRIM21 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000315;IPR001841;IPR001870;IPR003613;IPR003877;IPR003879;IPR006574;IPR013320;IPR017907;IPR020457 6737 tripartite motif containing 21 [Source:HGNC Symbol;Acc:HGNC:11312] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Matt Weirauch Sam Lambert No $#ENSG00000132109#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IDA - PMID:19675099$#ENSG00000132109#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:23077300 $#ENSP00000254436#ENSG00000132109#ENST00000254436#Other#PRY, SPRY, zf-B_box, zf-C3HC4, zf-C3HC4_2, zf-C3HC$#ENSP00000434053#ENSG00000132109#ENST00000533692#Other#PRY FALSE 2673 ENSG00000132274 TRIM22 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000315;IPR001841;IPR001870;IPR003877;IPR003879;IPR013320;IPR017907 10346 tripartite motif containing 22 [Source:HGNC Symbol;Acc:HGNC:16379] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Laura Campitelli Yimeng Yin No $#ENSG00000132274#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:7797467$#ENSG00000132274#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:23077300$#ENSG00000132274#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IDA - PMID:23077300 $#ENSP00000369299#ENSG00000132274#ENST00000379965#Other#SPRY, U-box, zf-B_box, zf-C3HC4, zf-C3HC4_2, zf-C3$#ENSP00000409991#ENSG00000132274#ENST00000429063#Other#$#ENSP00000404204#ENSG00000132274#ENST00000444844#Other#$#ENSP00000396849#ENSG00000132274#ENST00000414641#Other#U-box, zf-B_box, zf-C3HC4, zf-C3HC4_2, zf-C3HC4_3, FALSE 2674 ENSG00000113595 TRIM23 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000315;IPR001841;IPR003579;IPR003649;IPR005225;IPR006687;IPR006689;IPR007087;IPR017907;IPR024156;IPR027417; 373 tripartite motif containing 23 [Source:HGNC Symbol;Acc:HGNC:660] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Sam Lambert Yimeng Yin No None $#ENSP00000231524#ENSG00000113595#ENST00000231524#Other#Arf, G-alpha, Gtr1_RagA, MMR_HSR1, Prok-RING_4, Ra$#ENSP00000274327#ENSG00000113595#ENST00000274327#Other#Arf, G-alpha, Gtr1_RagA, MMR_HSR1, Prok-RING_4, Ra$#ENSP00000370406#ENSG00000113595#ENST00000381018#Other#Arf, G-alpha, Gtr1_RagA, MMR_HSR1, Prok-RING_4, Ra$#ENSP00000422144#ENSG00000113595#ENST00000513794#Other# FALSE 2675 ENSG00000122779 TRIM24 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Known cofactor. Included because TF-CAT documents this. Does not have any canonical DBDs. IPR000315;IPR001487;IPR001841;IPR001965;IPR003649;IPR011011;IPR017907;IPR018359;IPR019786;IPR019787 8805 tripartite motif containing 24 [Source:HGNC Symbol;Acc:HGNC:11812] None not tested not tested None None No No TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_DNA Binding_PMIDS:8978696;10598587 No 5a, one of the source datasets predicts is as a TF Tim Hughes Pratyush Das No None $##ENSG00000122779##Other# FALSE 2676 ENSG00000121060 TRIM25 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR001841;IPR001870;IPR003877;IPR003879;IPR006574;IPR013320;IPR017907 100500827 tripartite motif containing 25 [Source:HGNC Symbol;Acc:HGNC:12932];E3 ubiquitin/ISG15 ligase TRIM25 None not tested not tested None None No No Not a TF - Evidence that it is not a TF__Other_PMIDS:12943693 Yes 5a, one of the source datasets predicts is as a TF Matt Weirauch Jussi Taipale No $#ENSG00000121060#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:8248217$#ENSG00000121060#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IMP - PMID:23077300$#ENSG00000121060#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IMP - PMID:23077300 $#ENSP00000323889#ENSG00000121060#ENST00000316881#Other#PRY, Prok-RING_4, SPRY, zf-B_box, zf-C3HC4, zf-C3H$#ENSP00000445961#ENSG00000121060#ENST00000537230#Other#PRY, Prok-RING_4, SPRY, zf-B_box, zf-C3HC4, zf-C3H FALSE 2677 ENSG00000234127 TRIM26 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000315;IPR001841;IPR001870;IPR003877;IPR003879;IPR006574;IPR013320;IPR020457 7726 tripartite motif containing 26 [Source:HGNC Symbol;Acc:HGNC:12962] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Jussi Taipale Laura Campitelli No None None FALSE 2678 ENSG00000204713 TRIM27 Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None Evidence presented in (PMID: 1437549) for DNA-binding of alias RFP is not strong - if anything, this is likely a non-specific DNA binder IPR000315;IPR001841;IPR001870;IPR003877;IPR003879;IPR006574;IPR013320;IPR017907;IPR020457 5987 tripartite motif containing 27 [Source:HGNC Symbol;Acc:HGNC:9975];Zinc finger protein RFP None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Laura Campitelli Pratyush Das No None None FALSE 2679 ENSG00000130726 TRIM28 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif Only known motifs are from Transfac or HocoMoco - origin is uncertain This protein a well-known co-repressor and is recruited to DNA by KRAB-domain containing TFs. Transfac motifs are likely from interacting proteins IPR000315;IPR001487;IPR001841;IPR001965;IPR003649;IPR011011;IPR019786;IPR019787 10155 tripartite motif containing 28 [Source:HGNC Symbol;Acc:HGNC:16384];Transcription intermediary factor None not tested not tested None None No Yes TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:8986806 Yes 2a1, Lower confidence direct evidence Yimeng Yin Sam Lambert No $#ENSG00000130726#GO:0003700#sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024 $#ENSP00000253024#ENSG00000130726#ENST00000253024#Other#PHD, PHD_2, zf-B_box, zf-C3HC4, zf-RING_2, zf-RING$#ENSP00000342232#ENSG00000130726#ENST00000341753#Other#PHD, PHD_2, zf-B_box, zf-C3HC4, zf-RING_2, zf-RING$#ENSP00000471303#ENSG00000130726#ENST00000597136#Other#PHD, PHD_2$#ENSP00000470503#ENSG00000130726#ENST00000597968#Other#zf-B_box$#ENSP00000472586#ENSG00000130726#ENST00000593582#Other#zf-B_box FALSE 2680 ENSG00000137699 TRIM29 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Previous evidence for TF activity (PMID: 8188213) is based on sequence analysis and does not provide DNA-binding evidence. Based on EntrezGene information, its likely a transcriptional co-factor IPR000315 23650 tripartite motif containing 29 [Source:HGNC Symbol;Acc:HGNC:17274] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Sam Lambert Jussi Taipale No $#ENSG00000137699#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:8188213 $#ENSP00000343129#ENSG00000137699#ENST00000341846#Other#zf-B_box$#ENSP00000435696#ENSG00000137699#ENST00000528870#Other#$#ENSP00000436015#ENSG00000137699#ENST00000529044#Other#Med4$#ENSP00000436279#ENSG00000137699#ENST00000526881#Other# FALSE 2681 ENSG00000110171 TRIM3 Unknown No ssDNA/RNA binding Not a DNA binding protein No motif None Contains multiple NHL domains, which bind RNA (see, for example, LRP8). IPR000315;IPR001258;IPR001298;IPR001841;IPR003649;IPR013017;IPR014756;IPR017868;IPR017907;IPR018957 10612 tripartite motif containing 3 [Source:HGNC Symbol;Acc:HGNC:10064] None Full not tested None None x No No No 5a, one of the source datasets predicts is as a TF Yimeng Yin Tim Hughes No None $#ENSP00000340797#ENSG00000110171#ENST00000345851#Other#DUF4934, DUF5128, Filamin, NHL, Prok-RING_4, SBBP,$#ENSP00000433102#ENSG00000110171#ENST00000525074#Other#DUF4934, DUF5128, Filamin, NHL, Prok-RING_4, SBBP,$#ENSP00000445460#ENSG00000110171#ENST00000536344#Other#DUF4934, DUF5128, Filamin, NHL, SBBP, SGL, zf-B_bo$#ENSP00000437283#ENSG00000110171#ENST00000529529#Other#Prok-RING_4, zf-ANAPC11, zf-C3HC4, zf-C3HC4_2, zf- FALSE 2682 ENSG00000204616 TRIM31 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000315;IPR001841;IPR017907;IPR020457 11074 tripartite motif containing 31 [Source:HGNC Symbol;Acc:HGNC:16289];E3 ubiquitin-protein ligase TRIM31 None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Jussi Taipale Yimeng Yin No None None FALSE 2683 ENSG00000119401 TRIM32 Unknown No ssDNA/RNA binding Not a DNA binding protein No motif None None IPR000315;IPR001258;IPR001841;IPR013017;IPR017907;IPR027370 22954 tripartite motif containing 32 [Source:HGNC Symbol;Acc:HGNC:16380] None not tested not tested None None x No No Yes 4a, two or more datasets predict it as a TF Jussi Taipale Matt Weirauch No $#ENSG00000119401#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:23077300$#ENSG00000119401#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IDA - PMID:23077300 | ISS - GO_REF:0000024 $#ENSP00000363095#ENSG00000119401#ENST00000373983#Other#Baculo_IE-1, NHL, Prok-RING_4, SGL, zf-B_box, zf-C$#ENSP00000408292#ENSG00000119401#ENST00000450136#Other#Baculo_IE-1, NHL, Prok-RING_4, SGL, zf-B_box, zf-C$#ENSP00000412603#ENSG00000119401#ENST00000411410#Other#Baculo_IE-1, FYVE, Prok-RING_4, Zn_Tnp_IS1595, zf- FALSE 2684 ENSG00000197323 TRIM33 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000315;IPR001487;IPR001841;IPR001965;IPR003649;IPR011011;IPR017907;IPR019786;IPR019787 51592 tripartite motif containing 33 [Source:HGNC Symbol;Acc:HGNC:16290] None not tested not tested None None No No TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_Other_PMIDS:10022127;12096914 No 5a, one of the source datasets predicts is as a TF Sam Lambert Laura Campitelli No None $##ENSG00000197323##Other# FALSE 2685 ENSG00000258659 TRIM34 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000315;IPR001841;IPR001870;IPR003877;IPR003879;IPR013320;IPR017907 53840 tripartite motif containing 34 [Source:HGNC Symbol;Acc:HGNC:10063] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Pratyush Das Jussi Taipale No $#ENSG00000258659#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:23077300 $#ENSP00000402595#ENSG00000258659#ENST00000429814#Other#SPRY, zf-B_box, zf-C3HC4, zf-C3HC4_2, zf-C3HC4_3, $#ENSP00000422947#ENSG00000258659#ENST00000514226#Other#SPRY, zf-B_box, zf-C3HC4, zf-C3HC4_2, zf-C3HC4_3, FALSE 2686 ENSG00000108395 TRIM37 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Included only because GO says it is a regulator of NFkappaB. No evidence for DNA binding, and no canonical DBD. IPR000315;IPR001841;IPR002083;IPR003649;IPR008974 4591 tripartite motif containing 37 [Source:HGNC Symbol;Acc:HGNC:7523] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Tim Hughes Laura Campitelli No $#ENSG00000108395#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IDA - PMID:11279055$#ENSG00000108395#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:23077300$#ENSG00000108395#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IDA - PMID:23077300 $#ENSP00000262294#ENSG00000108395#ENST00000262294#Other#MATH, zf-B_box, zf-C3HC4_2, zf-C3HC4_3$#ENSP00000376785#ENSG00000108395#ENST00000393066#Other#MATH, zf-B_box, zf-C3HC4_2, zf-C3HC4_3$#ENSP00000376784#ENSG00000108395#ENST00000393065#Other#MATH, zf-B_box$#ENSP00000464263#ENSG00000108395#ENST00000584889#Other#zf-C3HC4_2, zf-C3HC4_3, zf-RING_2$#ENSP00000462778#ENSG00000108395#ENST00000583945#Other# FALSE 2687 ENSG00000112343 TRIM38 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000315;IPR001841;IPR001870;IPR003877;IPR003879;IPR006574;IPR013320;IPR017907 10475 tripartite motif containing 38 [Source:HGNC Symbol;Acc:HGNC:10059] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Jussi Taipale Yimeng Yin No $#ENSG00000112343#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:23077300$#ENSG00000112343#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IDA - PMID:23077300 $#ENSP00000349596#ENSG00000112343#ENST00000357085#Other#PRY, SPRY, U-box, zf-B_box, zf-C3HC4, zf-C3HC4_2, FALSE 2688 ENSG00000204614 TRIM40 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Protein that promotes post-translational modification of an NBKB-inhibitor protein (PMID: 21474709) IPR000315;IPR001841;IPR017907 135644 tripartite motif containing 40 [Source:HGNC Symbol;Acc:HGNC:18736] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Jussi Taipale Arttu Jolma No None None FALSE 2689 ENSG00000132256 TRIM5 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None No DBD and no evidence for DNA binding. Included as a candidate only because GO says its a regulator. IPR000315;IPR001841;IPR001870;IPR003877;IPR003879;IPR013320;IPR017907 85363 tripartite motif containing 5 [Source:HGNC Symbol;Acc:HGNC:16276] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Tim Hughes Laura Campitelli No $#ENSG00000132256#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IMP - PMID:23077300$#ENSG00000132256#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IMP - PMID:21512573, PMID:23077300 $#ENSP00000380058#ENSG00000132256#ENST00000396847#Other#FAM76, TMF_TATA_bd, U-box, zf-B_box, zf-C3HC4, zf-$#ENSP00000388031#ENSG00000132256#ENST00000412903#Other#TMF_TATA_bd, U-box, zf-B_box, zf-C3HC4, zf-C3HC4_2$#ENSP00000369373#ENSG00000132256#ENST00000380034#Other#FAM76, SPRY, TMF_TATA_bd, U-box, zf-B_box, zf-C3HC$#ENSP00000398196#ENSG00000132256#ENST00000438025#Other#TMF_TATA_bd FALSE 2690 ENSG00000183718 TRIM52 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Established ubiquitin ligase that targets at least one viral protein (NS2A) of Japanese Encephalitis Virus to proteosomal degradation (PMID: 27667714) IPR000315;IPR001841;IPR017907 84851 tripartite motif containing 52 [Source:HGNC Symbol;Acc:HGNC:19024] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Arttu Jolma Jussi Taipale No $#ENSG00000183718#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IDA - PMID:23077300 $#ENSP00000483005#ENSG00000183718#ENST00000611618#Other#zf-B_box, zf-C3HC4, zf-C3HC4_2, zf-C3HC4_3, zf-C3H FALSE 2691 ENSG00000116525 TRIM62 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Protein is a ubiguitin ligase (PMID: 23402750) IPR000315;IPR001841;IPR001870;IPR003877;IPR003879;IPR006574;IPR013320;IPR017907 55223 tripartite motif containing 62 [Source:HGNC Symbol;Acc:HGNC:25574];E3 ubiquitin-protein ligase TRIM6 None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Jussi Taipale Arttu Jolma No $#ENSG00000116525#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IMP - PMID:23077300$#ENSG00000116525#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IMP - PMID:23077300 $#ENSP00000291416#ENSG00000116525#ENST00000291416#Other#AAA_13, CorA, DUF3416, KxDL, PRY, SPRY, zf-B_box, $#ENSP00000441173#ENSG00000116525#ENST00000543586#Other#Fib_alpha, LXG, PRY, SPRY FALSE 2692 ENSG00000171206 TRIM8 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR001841;IPR017907 81603 tripartite motif containing 8 [Source:HGNC Symbol;Acc:HGNC:15579] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Jussi Taipale Yimeng Yin No $#ENSG00000171206#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:23077300$#ENSG00000171206#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IDA - PMID:23077300 $#ENSP00000302120#ENSG00000171206#ENST00000302424#Other#zf-B_box, zf-C3HC4, zf-C3HC4_2, zf-C3HC4_3, zf-C3H$#ENSP00000473428#ENSG00000171206#ENST00000462202#Other#zf-B_box FALSE 2693 ENSG00000100815 TRIP11 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Structural component of the Golgi-apparatus (PMID: 19112494) IPR000237 9321 thyroid hormone receptor interactor 11 [Source:HGNC Symbol;Acc:HGNC:12305] None not tested not tested None None No No TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:9256431 No 5a, one of the source datasets predicts is as a TF Tim Hughes Arttu Jolma No None $##ENSG00000100815##Other# FALSE 2694 ENSG00000043514 TRIT1 Unknown No ssDNA/RNA binding Not a DNA binding protein No motif None Protein is a tRNA modifying enzyme (PMID: 15870694) IPR003604;IPR018022;IPR022755;IPR027417 54802 tRNA isopentenyltransferase 1 [Source:HGNC Symbol;Acc:HGNC:20286] None Full not tested None None x No No No 5a, one of the source datasets predicts is as a TF Sam Lambert Arttu Jolma No None $#ENSP00000321810#ENSG00000043514#ENST00000316891#Other#AAA_16, AAA_18, AAA_28, AAA_33, IPPT, IPT, zf-C2H2$#ENSP00000361905#ENSG00000043514#ENST00000372818#Other#AAA_16, AAA_18, AAA_28, AAA_33, IPPT, IPT, zf-C2H2$#ENSP00000388333#ENSG00000043514#ENST00000441669#Other#AAA_16, AAA_18, AAA_22, AAA_25, AAA_28, AAA_33, AB$#ENSP00000437896#ENSG00000043514#ENST00000541099#Other#zf-C2H2_jaz, zf-met FALSE 2695 ENSG00000121486 TRMT1L Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR002905;IPR007087;IPR015880;IPR029063 81627 tRNA methyltransferase 1 like [Source:HGNC Symbol;Acc:HGNC:16782] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Jussi Taipale Pratyush Das No None $#ENSP00000356476#ENSG00000121486#ENST00000367506#Other#Met_10, Methyltransf_25, Methyltransf_31, TRM$#ENSP00000414339#ENSG00000121486#ENST00000458395#Other#TRM FALSE 2696 ENSG00000196367 TRRAP Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Protein is a component of histone acetyltransferase complexes IPR000403;IPR003151;IPR003152;IPR011009;IPR014009;IPR016024 8295 transformation/transcription domain associated protein [Source:HGNC Symbol;Acc:HGNC:12347] None not tested not tested None None No No TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:9708738 No 5a, one of the source datasets predicts is as a TF Pratyush Das Arttu Jolma No None $##ENSG00000196367##Other# FALSE 2697 ENSG00000103197 TSC2 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000331;IPR003913;IPR016024;IPR018515;IPR024584 7249 tuberous sclerosis 2 [Source:HGNC Symbol;Acc:HGNC:12363] None not tested not tested None None No No TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:15249583 No 5a, one of the source datasets predicts is as a TF Jussi Taipale Matt Weirauch No None $##ENSG00000103197##Other# FALSE 2698 ENSG00000102804 TSC22D1 Unknown Yes Likely to be sequence specific TF Monomer or homomultimer No motif None TSC22D1 appears to homo- and heterodimerize with other TFs to affect transcription (PMID: 10488076). In vitro, it has been shown to bind GC-rich DNA sequences (PMID: 9022669) IPR000580; 8848 TSC22 domain family member 1 [Source:HGNC Symbol;Acc:HGNC:16826] None not tested not tested None None a No TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_Transactivation_PMIDS:10488076 Yes 4a, two or more datasets predict it as a TF Sam Lambert Jussi Taipale Yes $#ENSG00000102804#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000261489#ENSG00000102804#ENST00000261489#Other#DUF972, DivIC, SOGA, TSC22, ZapB$#ENSP00000397435#ENSG00000102804#ENST00000458659#Other#DUF972, K-box, TSC22$#ENSP00000437414#ENSG00000102804#ENST00000501704#Other#SUIM_assoc$#ENSP00000481585#ENSG00000102804#ENST00000611198#Other#DUF972, DivIC, SOGA, TSC22, ZapB$#ENSP00000483407#ENSG00000102804#ENST00000622051#Other#DUF972, DivIC, SOGA, TSC22, ZapB FALSE 2699 ENSG00000196428 TSC22D2 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None There is some evidence that a related protein (TSC22D1) binds DNA specifically - thus, it is possible this is also a TF. IPR000580; 9819 TSC22 domain family member 2 [Source:HGNC Symbol;Acc:HGNC:29095] None not tested not tested None None b No No Yes 4a, two or more datasets predict it as a TF Sam Lambert Jussi Taipale Yes $#ENSG00000196428#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000354543#ENSG00000196428#ENST00000361875#Other#TSC22$#ENSP00000417747#ENSG00000196428#ENST00000466814#Other#DUF972, K-box, TSC22, ZapB$#ENSP00000418149#ENSG00000196428#ENST00000480589#Other# FALSE 2700 ENSG00000157514 TSC22D3 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None There is some evidence that a related protein (TSC22D1) binds DNA specifically - thus, it is possible this is also a TF. IPR000580; 1831 TSC22 domain family member 3 [Source:HGNC Symbol;Acc:HGNC:3051] None DBD not tested None None a No Probably Not a TF - No evidence that it is a TF___PMIDS:0 Yes 4a, two or more datasets predict it as a TF Jussi Taipale Matt Weirauch Yes $#ENSG00000157514#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002 $#ENSP00000314655#ENSG00000157514#ENST00000315660#Other#DUF972, DivIC, NPV_P10, TSC22, ZapB$#ENSP00000361466#ENSG00000157514#ENST00000372390#Other#DUF972, DivIC, Lebercilin, NPV_P10, TSC22, ZapB$#ENSP00000361474#ENSG00000157514#ENST00000372397#Other#DUF972, DivIC, K-box, NPV_P10, TSC22, ZapB$#ENSP00000361458#ENSG00000157514#ENST00000372383#Other#DUF972, DivIC, NPV_P10, TSC22, ZapB$#ENSP00000361459#ENSG00000157514#ENST00000372384#Other#DUF972, DivIC, NPV_P10, TSC22, ZapB$#ENSP00000425414#ENSG00000157514#ENST00000486554#Other#TSC22$#ENSP00000422060#ENSG00000157514#ENST00000503515#Other#$#ENSP00000361457#ENSG00000157514#ENST00000372382#Other#DUF972, DivIC, K-box, NPV_P10, TSC22, ZapB$#ENSP00000425158#ENSG00000157514#ENST00000505965#Other# FALSE 2701 ENSG00000166925 TSC22D4 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None There is some evidence that a related protein (TSC22D1) binds DNA specifically - thus, it is possible this is also a TF. IPR000580; 81628 TSC22 domain family member 4 [Source:HGNC Symbol;Acc:HGNC:21696] None DBD not tested None None b No No Yes 4a, two or more datasets predict it as a TF Sam Lambert Yimeng Yin Yes $#ENSG00000166925#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000300181#ENSG00000166925#ENST00000300181#Other#DUF972, TSC22$#ENSP00000377560#ENSG00000166925#ENST00000393991#Other#DUF972, DivIC, K-box, TSC22, ZapB$#ENSP00000388168#ENSG00000166925#ENST00000423266#Other#DUF972, K-box, TSC22, ZapB$#ENSP00000395795#ENSG00000166925#ENST00000456330#Other# FALSE 2702 ENSG00000211460 TSN Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None Based on (PMID: 20450889) and (PMID: 12484770), this protein binds repetitive DNA sequences as multimeric complexes that may contain partner protein TSNAX IPR002848 7247 translin [Source:HGNC Symbol;Acc:HGNC:12379] None not tested not tested None None No No Indeterminate - There is no evidence for or against this genes role as a TF__DNA Binding_PMIDS:9159125;10434033 No 5a, one of the source datasets predicts is as a TF Yimeng Yin Arttu Jolma No None $##ENSG00000211460##Other# FALSE 2703 ENSG00000139908 TSSK4 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000719;IPR002290;IPR008271;IPR011009;IPR017441 283629 testis specific serine kinase 4 [Source:HGNC Symbol;Acc:HGNC:19825] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Sam Lambert Yimeng Yin No $#ENSG00000139908#GO:0032793#positive regulation of CREB transcription factor activity#IDA - PMID:15964553 $#ENSP00000287913#ENSG00000139908#ENST00000287913#Other#APH, Kdo, Kinase-like, Pkinase, Pkinase_Tyr$#ENSP00000452054#ENSG00000139908#ENST00000556621#Other#APH, Kdo, Kinase-like, Pkinase, Pkinase_Tyr$#ENSP00000339179#ENSG00000139908#ENST00000339917#Other#Pkinase, Pkinase_Tyr$#ENSP00000412180#ENSG00000139908#ENST00000428351#Other#Pkinase, Pkinase_Tyr$#ENSP00000450752#ENSG00000139908#ENST00000553766#Other#Pkinase, Pkinase_Tyr FALSE 2704 ENSG00000166402 TUB Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None The Tubby C-terminal domain (IPR000007; PF01167) has been shown to impart nuclear localization and bind select dsDNA sequences in gel-shift experiments (PMID: 10591637). This article hypothesized that this domain constitutes a bona fide sequence specific TF, but no concrete evidence for this exists to date IPR000007;IPR005398;IPR018066;IPR025659 7275 tubby bipartite transcription factor [Source:HGNC Symbol;Acc:HGNC:12406] None not tested not tested None None other No No No 5a, one of the source datasets predicts is as a TF Sam Lambert Pratyush Das No None $#ENSP00000299506#ENSG00000166402#ENST00000299506#Other#Tub, Tub_N$#ENSP00000305426#ENSG00000166402#ENST00000305253#Other#Tub, Tub_N$#ENSP00000434400#ENSG00000166402#ENST00000534099#Other#Tub, Tub_N FALSE 2705 ENSG00000130338 TULP4 Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None (PMID: 10591637) shows that it binds dsDNA. All other research, however, supports phosphoinositide-binding as the major function of the tubby domain. IPR000007;IPR001496;IPR001680;IPR008983;IPR017986;IPR025659 56995 tubby like protein 4 [Source:HGNC Symbol;Acc:HGNC:15530] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Pratyush Das Matt Weirauch No $#ENSG00000130338#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:11595174 $#ENSP00000356061#ENSG00000130338#ENST00000367094#Other#ANAPC4_WD40, SOCS_box, Tub$#ENSP00000356064#ENSG00000130338#ENST00000367097#Other#ANAPC4_WD40, SOCS_box, Tub FALSE 2706 ENSG00000149016 TUT1 Unknown No ssDNA/RNA binding Not a DNA binding protein No motif None None IPR000504;IPR002058 64852 terminal uridylyl transferase 1, U6 snRNA-specific [Source:HGNC Symbol;Acc:HGNC:26184] None Full not tested None None x No No No 5a, one of the source datasets predicts is as a TF Yimeng Yin Matt Weirauch No None $#ENSP00000308000#ENSG00000149016#ENST00000308436#Other#PAP_assoc, zf-met$#ENSP00000419607#ENSG00000149016#ENST00000476907#Other#PAP_assoc, zf-met$#ENSP00000420739#ENSG00000149016#ENST00000494385#Other#$#ENSP00000278279#ENSG00000149016#ENST00000278279#Other#zf-met FALSE 2707 ENSG00000074966 TXK Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Experimental evidence for DNA-binding was performed with nuclear extract - thus, the apparent specific-binding of TXK could be due to indirect binding (PMID: 11859127). In addition a whitepaper suggests that this interaction could not be replicated (Miskimins, Beth) IPR000719;IPR000980;IPR001245;IPR001452;IPR008266;IPR011009;IPR017441;IPR020635 7294 TXK tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:12434] None not tested not tested None None No No Indeterminate - There is no evidence for or against this genes role as a TF__DNA Binding_PMIDS:11859127 Yes 4a, two or more datasets predict it as a TF Sam Lambert Yimeng Yin No $#ENSG00000074966#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:11859127 $#ENSP00000264316#ENSG00000074966#ENST00000264316#Other#Pkinase, Pkinase_Tyr, SH2, SH3_1, SH3_9$#ENSP00000423481#ENSG00000074966#ENST00000507351#Other#Pkinase, Pkinase_Tyr$#ENSP00000422798#ENSG00000074966#ENST00000506073#Other#SH3_1, SH3_9 FALSE 2708 ENSG00000160201 U2AF1 Unknown No ssDNA/RNA binding Not a DNA binding protein No motif None Well-established RNA binding protein IPR000504;IPR000571;IPR003954;IPR009145 102724594 U2 small nuclear RNA auxiliary factor 1 [Source:HGNC Symbol;Acc:HGNC:12453] None Full Yes None None x No No No 5a, one of the source datasets predicts is as a TF Jussi Taipale Laura Campitelli No None $#ENSP00000291552#ENSG00000160201#ENST00000291552#Other#$#ENSP00000369629#ENSG00000160201#ENST00000380276#Other#$#ENSP00000381205#ENSG00000160201#ENST00000398137#Other#$#ENSP00000418705#ENSG00000160201#ENST00000459639#Other# FALSE 2709 ENSG00000161265 U2AF1L4 Unknown No ssDNA/RNA binding Not a DNA binding protein No motif None Related to U2AF1, so likely also an RNA binding protein. IPR000504;IPR000571;IPR003954;IPR009145 199746 U2 small nuclear RNA auxiliary factor 1-like 4 [Source:HGNC Symbol;Acc:HGNC:23020] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Sam Lambert Pratyush Das No None $#ENSP00000292879#ENSG00000161265#ENST00000292879#Other#$#ENSP00000368258#ENSG00000161265#ENST00000378975#Other#$#ENSP00000467441#ENSG00000161265#ENST00000587886#Other#$#ENSP00000397645#ENSG00000161265#ENST00000412391#Other# FALSE 2710 ENSG00000221983 UBA52 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000626;IPR001975;IPR011332;IPR019954;IPR019956;IPR029071 7311 ubiquitin A-52 residue ribosomal protein fusion product 1 [Source:HGNC Symbol;Acc:HGNC:12458] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Laura Campitelli Pratyush Das No $#ENSG00000221983#GO:0051092#positive regulation of NF-kappaB transcription factor activity#TAS - Reactome:R-HSA-445989 $#ENSP00000396910#ENSG00000221983#ENST00000430157#Other#Rad60-SLD, Rad60-SLD_2, Ribosomal_L40e, Ubiquitin_$#ENSP00000388107#ENSG00000221983#ENST00000442744#Other#Rad60-SLD, Rad60-SLD_2, Ribosomal_L40e, Ubiquitin_$#ENSP00000473048#ENSG00000221983#ENST00000597451#Other#Rad60-SLD, Rad60-SLD_2, Ribosomal_L40e, Ubiquitin_$#ENSP00000470419#ENSG00000221983#ENST00000595683#Other#Rad60-SLD, Rad60-SLD_2, Ribosomal_L40e, Ubiquitin_$#ENSP00000472768#ENSG00000221983#ENST00000596272#Other#Rad60-SLD, Ribosomal_L40e, Ubiquitin_2, ubiquitin$#ENSP00000471062#ENSG00000221983#ENST00000596273#Other#Rad60-SLD, Rad60-SLD_2, Ribosomal_L40e, Ubiquitin_$#ENSP00000472137#ENSG00000221983#ENST00000599256#Other#Rad60-SLD, Rad60-SLD_2, Ubiquitin_2, ubiquitin$#ENSP00000470507#ENSG00000221983#ENST00000599551#Other#Rad60-SLD, Rad60-SLD_2, Ribosomal_L40e, Ubiquitin_$#ENSP00000471991#ENSG00000221983#ENST00000594527#Other#Rad60-SLD, Ribosomal_L40e, ubiquitin$#ENSP00000471622#ENSG00000221983#ENST00000595158#Other#Rad60-SLD, Rad60-SLD_2, Ribosomal_L40e, Ubiquitin_$#ENSP00000472545#ENSG00000221983#ENST00000598780#Other#Rad60-SLD, Rad60-SLD_2, Ribosomal_L40e, Ubiquitin_$#ENSP00000471464#ENSG00000221983#ENST00000599595#Other#Rad60-SLD, Rad60-SLD_2, Ribosomal_L40e, Ubiquitin_ FALSE 2711 ENSG00000170315 UBB Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000626;IPR019954;IPR019956;IPR029071 7314 ubiquitin B [Source:HGNC Symbol;Acc:HGNC:12463];Polyubiquitin-B 4ZUX not tested not tested None None No No No Yes 3a, decent circumstantial evidence for its role as Arttu Jolma Jussi Taipale No $#ENSG00000170315#GO:0051092#positive regulation of NF-kappaB transcription factor activity#TAS - Reactome:R-HSA-445989 $#ENSP00000304697#ENSG00000170315#ENST00000302182#Other#DUF2407, DUF2870, DUF969, Methyltrans_RNA, Rad60-S$#ENSP00000379178#ENSG00000170315#ENST00000395837#Other#DUF2407, DUF2870, DUF969, Methyltrans_RNA, Rad60-S$#ENSP00000379180#ENSG00000170315#ENST00000395839#Other#DUF2407, DUF2870, DUF969, Methyltrans_RNA, Rad60-S$#ENSP00000437475#ENSG00000170315#ENST00000535788#Other#DUF2407, DUF2870, FERM_f0, Rad60-SLD, Rad60-SLD_2,$#ENSP00000464594#ENSG00000170315#ENST00000577958#Other#Rad60-SLD, Ubiquitin_2, ubiquitin$#ENSP00000464510#ENSG00000170315#ENST00000578706#Other#Rad60-SLD, Rad60-SLD_2, Ubiquitin_2, ubiquitin$#ENSP00000478771#ENSG00000170315#ENST00000614404#Other#DUF2407, DUF2870, DUF969, Methyltrans_RNA, Rad60-S FALSE 2712 ENSG00000150991 UBC Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000626;IPR019954;IPR019956;IPR029071 7316 ubiquitin C [Source:HGNC Symbol;Acc:HGNC:12468];Polyubiquitin-C None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Laura Campitelli Arttu Jolma No $#ENSG00000150991#GO:0051092#positive regulation of NF-kappaB transcription factor activity#TAS - Reactome:R-HSA-445989 $#ENSP00000344818#ENSG00000150991#ENST00000339647#Other#DUF2407, Rad60-SLD, Rad60-SLD_2, Ubiquitin_2, ubiq$#ENSP00000442800#ENSG00000150991#ENST00000540351#Other#DUF2407, DUF2870, FERM_f0, Rad60-SLD, Rad60-SLD_2,$#ENSP00000437452#ENSG00000150991#ENST00000535859#Other#Rad60-SLD, Rad60-SLD_2, Ubiquitin_2, ubiquitin$#ENSP00000441238#ENSG00000150991#ENST00000540700#Other#DUF2407, RBD, Rad60-SLD, Rad60-SLD_2, Ubiquitin_2,$#ENSP00000445337#ENSG00000150991#ENST00000541645#Other#DUF2407, DUF2870, FERM_f0, Rad60-SLD, Rad60-SLD_2,$#ENSP00000441543#ENSG00000150991#ENST00000536769#Other#DUF2407, Rad60-SLD, Rad60-SLD_2, Ubiquitin_2, ubiq FALSE 2713 ENSG00000078140 UBE2K Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000449;IPR000608;IPR009060;IPR015940;IPR016135;IPR023313 3093 ubiquitin conjugating enzyme E2 K [Source:HGNC Symbol;Acc:HGNC:4914] None Full not tested None None x No No No 5a, one of the source datasets predicts is as a TF Yimeng Yin Matt Weirauch No None $#ENSP00000261427#ENSG00000078140#ENST00000261427#Other#Prok-E2_B, RWD, UBA, UQ_con$#ENSP00000390483#ENSG00000078140#ENST00000445950#Other#Prok-E2_B, RWD, UQ_con$#ENSP00000421203#ENSG00000078140#ENST00000503368#Other#UBA, UQ_con$#ENSP00000425301#ENSG00000078140#ENST00000510934#Other#UBA, UQ_con FALSE 2714 ENSG00000177889 UBE2N Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000608;IPR016135;IPR023313 7334 ubiquitin conjugating enzyme E2 N [Source:HGNC Symbol;Acc:HGNC:12492] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Jussi Taipale Pratyush Das No $#ENSG00000177889#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IMP - PMID:14695475, PMID:16129784 $#ENSP00000316176#ENSG00000177889#ENST00000318066#Other#Prok-E2_B, UEV, UQ_con$#ENSP00000449352#ENSG00000177889#ENST00000550657#Other#UQ_con$#ENSP00000450260#ENSG00000177889#ENST00000549833#Other#UQ_con$#ENSP00000448352#ENSG00000177889#ENST00000552442#Other#UQ_con FALSE 2715 ENSG00000244687 UBE2V1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Ubiquitin ligase IPR000608;IPR016135 7335 ubiquitin conjugating enzyme E2 V1 [Source:HGNC Symbol;Acc:HGNC:12494] None not tested Yes None None No No No Yes 5a, one of the source datasets predicts is as a TF Yimeng Yin Arttu Jolma No $#ENSG00000244687#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IMP - PMID:16129784 $#ENSP00000340305#ENSG00000244687#ENST00000340309#Other#UQ_con$#ENSP00000360739#ENSG00000244687#ENST00000371674#Other#UQ_con$#ENSP00000407770#ENSG00000244687#ENST00000415862#Other#UQ_con$#ENSP00000360742#ENSG00000244687#ENST00000371677#Other#UQ_con FALSE 2716 ENSG00000118900 UBN1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Interacts with bZIP transcription factors (PMID: 10725330) IPR014840;IPR026947 29855 ubinuclein 1 [Source:HGNC Symbol;Acc:HGNC:12506] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Laura Campitelli Yimeng Yin No $#ENSG00000118900#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:10725330 $#ENSP00000262376#ENSG00000118900#ENST00000262376#Other#HUN, UBN_AB$#ENSP00000379894#ENSG00000118900#ENST00000396658#Other#HUN, UBN_AB$#ENSP00000468740#ENSG00000118900#ENST00000590769#Other#HUN, UBN_AB$#ENSP00000467942#ENSG00000118900#ENST00000592120#Other#HUN$#ENSP00000465309#ENSG00000118900#ENST00000586716#Other#UBN_AB FALSE 2717 ENSG00000127481 UBR4 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR003126;IPR013993;IPR016024;IPR017986;IPR025704; 23352 ubiquitin protein ligase E3 component n-recognin 4 [Source:HGNC Symbol;Acc:HGNC:30313] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Sam Lambert Jussi Taipale No None $#ENSP00000364403#ENSG00000127481#ENST00000375254#Other#E3_UbLigase_R4, zf-UBR$#ENSP00000364366#ENSG00000127481#ENST00000375218#Other#DZR$#ENSP00000364372#ENSG00000127481#ENST00000375224#Other#E3_UbLigase_R4$#ENSP00000364373#ENSG00000127481#ENST00000375225#Other#E3_UbLigase_R4$#ENSP00000395313#ENSG00000127481#ENST00000425413#Other# FALSE 2718 ENSG00000228970 UBTFL6 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif Pseudogene According to ENSEMBL this is a Pseudogene, and it is of uncertain confidence in Uniprot. The most similar gene, UBTLF1, is annotated as No evidence for or against specific DNA-binding by this class of HMG box containing proteins. None Has no Entrez identifier Upstream binding transcription factor, RNA polymerase I-like 6 (pseudogene) None not tested not tested None None No No No No New proteins added after initial stage Arttu Jolma Sam Lambert Yes None None FALSE 2719 ENSG00000014123 UFL1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR018611 23376 UFM1 specific ligase 1 [Source:HGNC Symbol;Acc:HGNC:23039] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Jussi Taipale Matt Weirauch No $#ENSG00000014123#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IMP - PMID:20164180, PMID:20228063 $#ENSP00000358283#ENSG00000014123#ENST00000369278#Other#DUF2042 FALSE 2720 ENSG00000276043 UHRF1 Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None Structural evidence (PDB:2ZO0; PDB: 2ZO1; PMID: 18772888] and (PDB: 2ZKE) (PMID: 18772891) demonstrate direct DNA-binding. However, the extent to which it is sequence specific beyond hemimethylated DNA has not been extensively explored. IPR000626;IPR001841;IPR001965;IPR003105;IPR011011;IPR015947;IPR017907;IPR019787;IPR021991;IPR029071 29128 ubiquitin like with PHD and ring finger domains 1 [Source:HGNC Symbol;Acc:HGNC:12556] 2ZO2 not tested not tested None None No No No Yes 3a, decent circumstantial evidence for its role as Jussi Taipale Sam Lambert No $#ENSG00000276043#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:1868030 $#ENSP00000484739#ENSG00000276043#ENST00000612630#Other#PHD, PHD_2, Prok-RING_4, Rad60-SLD, SAD_SRA, TTD, $#ENSP00000478348#ENSG00000276043#ENST00000616255#Other#PHD, PHD_2, Prok-RING_4, Rad60-SLD, SAD_SRA, TTD, $#ENSP00000478171#ENSG00000276043#ENST00000620565#Other#PHD, PHD_2, Prok-RING_4, Rad60-SLD, SAD_SRA, TTD, $#ENSP00000479617#ENSG00000276043#ENST00000622802#Other#PHD, PHD_2, Prok-RING_4, Rad60-SLD, SAD_SRA, TTD, $#ENSP00000485604#ENSG00000276043#ENST00000624301#Other#PHD, PHD_2, Prok-RING_4, Rad60-SLD, SAD_SRA, TTD, $#ENSP00000480214#ENSG00000276043#ENST00000613817#Other#Prok-RING_4, SAD_SRA, zf-C3HC4, zf-C3HC4_2, zf-C3H$#ENSP00000478601#ENSG00000276043#ENST00000615884#Other#PHD, PHD_2, Prok-RING_4, Rad60-SLD, SAD_SRA, TTD, FALSE 2721 ENSG00000147854 UHRF2 Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None Binds DNA in the crystal structure contacting the minor groove and backbone (PDB: 4PW5). Recognizes 5hmC-containing DNA (PDB: 4PW5) None 115426 ubiquitin like with PHD and ring finger domains 2 4PW5 not tested not tested None None No No No No New proteins added based on PDB entry Arttu Jolma Sam Lambert No None None FALSE 2722 ENSG00000076248 UNG Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None Involved in mismatch repair. Excises uracil bases from DNA. Binds DNA in the crystal structure (PDB: 1EMJ) None 7374 uracil DNA glycosylase 1EMJ not tested not tested None None No No No No New proteins added based on PDB entry Arttu Jolma Sam Lambert No None None FALSE 2723 ENSG00000168883 USP39 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR001394;IPR001607;IPR028889; 10713 ubiquitin specific peptidase 39 [Source:HGNC Symbol;Acc:HGNC:20071] None not tested Yes None None x No No No 5a, one of the source datasets predicts is as a TF Sam Lambert Matt Weirauch No None $#ENSP00000312981#ENSG00000168883#ENST00000323701#Other#UCH, UCH_1, zf-UBP$#ENSP00000386864#ENSG00000168883#ENST00000409470#Other#UCH, UCH_1, zf-UBP$#ENSP00000386803#ENSG00000168883#ENST00000409766#Other#UCH, UCH_1, zf-UBP$#ENSP00000396133#ENSG00000168883#ENST00000450066#Other#UCH, UCH_1, zf-UBP$#ENSP00000484024#ENSG00000168883#ENST00000613444#Other#UCH, UCH_1, zf-UBP$#ENSP00000396854#ENSG00000168883#ENST00000448971#Other#zf-UBP FALSE 2724 ENSG00000187555 USP7 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR001394;IPR002083;IPR008974;IPR018200;IPR024729;IPR028889;IPR029346 7874 ubiquitin specific peptidase 7 (herpes virus-associated) [Source:HGNC Symbol;Acc:HGNC:12630] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Yimeng Yin Jussi Taipale No $#ENSG00000187555#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IDA - PMID:11279055$#ENSG00000187555#GO:0051090#regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:16964248 $#ENSP00000343535#ENSG00000187555#ENST00000344836#Other#MATH, UCH, UCH_1, USP7_C2, USP7_ICP0_bdg$#ENSP00000371310#ENSG00000187555#ENST00000381886#Other#MATH, UCH, UCH_1, USP7_C2, USP7_ICP0_bdg$#ENSP00000454795#ENSG00000187555#ENST00000563085#Other#MATH, UCH, UCH_1, USP7_C2, USP7_ICP0_bdg FALSE 2725 ENSG00000171794 UTF1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None None 8433 undifferentiated embryonic cell transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:12634] None not tested not tested None None No No TF Gene_Transcription Factor Binding: tf co-factor binding_Co-activation_PMIDS:9524124 No 5a, one of the source datasets predicts is as a TF Jussi Taipale Yimeng Yin Yes None $##ENSG00000171794##Other# FALSE 2726 ENSG00000141968 VAV1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Paper cited by GO annotation (PMID: 2477241) only presents evidence based on sequence similarity to a ZF motif, and other evidence (PMID: 11994417) only supports a role in coactivation of NFAT and NFKB without direct DNA-binding IPR000219;IPR000980;IPR001331;IPR001452;IPR001715;IPR001849;IPR002219;IPR003096;IPR022613 7409 vav guanine nucleotide exchange factor 1 [Source:HGNC Symbol;Acc:HGNC:12657] None not tested not tested None None No No TF Gene Candidate__TF PPI; Transactivation_PMIDS:11994417 Yes 4a, two or more datasets predict it as a TF Sam Lambert Yimeng Yin No $#ENSG00000141968#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:2477241 $#ENSP00000302269#ENSG00000141968#ENST00000304076#Other#C1_1, C1_2, CAMSAP_CH, CDC24, CH, PH, RhoGEF, SH2,$#ENSP00000472803#ENSG00000141968#ENST00000599806#Other#C1_1, C1_2, CAMSAP_CH, CH, PH, RhoGEF, SH2, SH3_1,$#ENSP00000472929#ENSG00000141968#ENST00000602142#Other#C1_1, C1_2, CAMSAP_CH, CDC24, CH, PH, RhoGEF, SH2,$#ENSP00000469450#ENSG00000141968#ENST00000596764#Other#C1_1, C1_2, CAMSAP_CH, CDC24, CH, PH, RhoGEF, SH2, FALSE 2727 ENSG00000112715 VEGFA Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Extracellular signaling molecule. Included only because it regulates CREB. IPR000072;IPR023581;IPR027928;IPR029034 7422 vascular endothelial growth factor A [Source:HGNC Symbol;Acc:HGNC:12680] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Tim Hughes Pratyush Das No $#ENSG00000112715#GO:0032793#positive regulation of CREB transcription factor activity#IDA - PMID:20497126 $#ENSP00000317598#ENSG00000112715#ENST00000324450#Other#PDGF$#ENSP00000361125#ENSG00000112715#ENST00000372055#Other#PDGF, VEGF_C$#ENSP00000361134#ENSG00000112715#ENST00000372064#Other#PDGF$#ENSP00000361137#ENSG00000112715#ENST00000372067#Other#PDGF, VEGF_C$#ENSP00000361148#ENSG00000112715#ENST00000372077#Other#PDGF$#ENSP00000389864#ENSG00000112715#ENST00000413642#Other#PDGF, VEGF_C$#ENSP00000388663#ENSG00000112715#ENST00000417285#Other#PDGF, VEGF_C$#ENSP00000388465#ENSG00000112715#ENST00000425836#Other#PDGF, VEGF_C$#ENSP00000409911#ENSG00000112715#ENST00000457104#Other#PDGF$#ENSP00000421561#ENSG00000112715#ENST00000482630#Other#PDGF, VEGF_C$#ENSP00000430829#ENSG00000112715#ENST00000518689#Other#PDGF, VEGF_C$#ENSP00000430002#ENSG00000112715#ENST00000518824#Other#PDGF, VEGF_C$#ENSP00000428321#ENSG00000112715#ENST00000520948#Other#PDGF, VEGF_C$#ENSP00000429008#ENSG00000112715#ENST00000523125#Other#PDGF, VEGF_C$#ENSP00000430479#ENSG00000112715#ENST00000523873#Other#PDGF, VEGF_C$#ENSP00000429643#ENSG00000112715#ENST00000523950#Other#PDGF, VEGF_C$#ENSP00000478570#ENSG00000112715#ENST00000611736#Other#PDGF, VEGF_C$#ENSP00000478034#ENSG00000112715#ENST00000615393#Other#PDGF$#ENSP00000484284#ENSG00000112715#ENST00000617771#Other#PDGF$#ENSP00000483241#ENSG00000112715#ENST00000621747#Other#PDGF, VEGF_C$#ENSP00000230480#ENSG00000112715#ENST00000230480#Other#PDGF, VEGF_C FALSE 2728 ENSG00000102243 VGLL1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Likely transcriptional cofactor (PMID: 10518497) None 51442 Transcription cofactor vestigial-like protein 1 None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Laura Campitelli Sam Lambert No $#ENSG00000102243#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $##ENSG00000102243##Other# FALSE 2729 ENSG00000170162 VGLL2 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Co-activator that binds TEF family TFs (PMID: 14762206) IPR011520 245806 vestigial like family member 2 [Source:HGNC Symbol;Acc:HGNC:20232] None not tested not tested None None No No TF Gene_Transcription Factor Binding: tf co-factor binding_Co-activation_PMIDS:14762206 No 5a, one of the source datasets predicts is as a TF Pratyush Das Sam Lambert No $#ENSG00000170162#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $##ENSG00000170162##Other# FALSE 2730 ENSG00000206538 VGLL3 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None (PMID: 23380592) describes this protein as a co-activator, and it doesnt seem to have a DBD (fig. 1) None 389136 Transcription cofactor vestigial-like protein 3 None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Jussi Taipale Pratyush Das No $#ENSG00000206538#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $##ENSG00000206538##Other# FALSE 2731 ENSG00000189030 VHLL Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Interacts with TFs as part of an E3 ubiquitin ligase complex (PMID: 12682018). No evidence for DNA binding. IPR022772 391104 von Hippel-Lindau tumor suppressor like [Source:HGNC Symbol;Acc:HGNC:30666] None not tested not tested None None No No TF Gene Candidate__Transactivation_PMIDS:12682018 No 5a, one of the source datasets predicts is as a TF Sam Lambert Yimeng Yin No None $##ENSG00000189030##Other# FALSE 2732 ENSG00000163159 VPS72 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None VPS72 (YL1) is a histone chaperone. YL1 binding to the H2A.Z-H2B dimer is mutually exclusive from the dimer binding DNA (PMID: 26974126) IPR008895;IPR013272 6944 vacuolar protein sorting 72 homolog [Source:HGNC Symbol;Acc:HGNC:11644] None not tested not tested None None x No Probably Not a TF - No evidence that it is a TF__Other_PMIDS:15647280 No 5a, one of the source datasets predicts is as a TF Sam Lambert Arttu Jolma No None $#ENSP00000357887#ENSG00000163159#ENST00000368892#Other#YL1, YL1_C$#ENSP00000346464#ENSG00000163159#ENST00000354473#Other#YL1, YL1_C FALSE 2733 ENSG00000109501 WFS1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR026208;IPR026209 7466 wolframin ER transmembrane glycoprotein [Source:HGNC Symbol;Acc:HGNC:12762] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Sam Lambert Jussi Taipale No $#ENSG00000109501#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:20160352 $#ENSP00000226760#ENSG00000109501#ENST00000226760#Other#$#ENSP00000423337#ENSG00000109501#ENST00000503569#Other#$#ENSP00000424103#ENSG00000109501#ENST00000506362#Other# FALSE 2734 ENSG00000125084 WNT1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR005817;IPR009139;IPR018161 7471 Wnt family member 1 [Source:HGNC Symbol;Acc:HGNC:12774] None not tested not tested None None No No Not a TF - Evidence that it is not a TF___PMIDS:0 Yes 5a, one of the source datasets predicts is as a TF Sam Lambert Jussi Taipale No $#ENSG00000125084#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024 $#ENSP00000293549#ENSG00000125084#ENST00000293549#Other#wnt$#ENSP00000481240#ENSG00000125084#ENST00000613114#Other#wnt FALSE 2735 ENSG00000169884 WNT10B Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Protein is a secreted signaling protein None 7480 Protein Wnt-10b None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Jussi Taipale Arttu Jolma No $#ENSG00000169884#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019 $##ENSG00000169884##Other# FALSE 2736 ENSG00000105989 WNT2 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR005817;IPR009140;IPR018161 7472 Wnt family member 2 [Source:HGNC Symbol;Acc:HGNC:12780] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Matt Weirauch Laura Campitelli No $#ENSG00000105989#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:10557084 $#ENSP00000265441#ENSG00000105989#ENST00000265441#Other#wnt$#ENSP00000419466#ENSG00000105989#ENST00000491214#Other#wnt FALSE 2737 ENSG00000154342 WNT3A Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None None 89780 Protein Wnt-3a None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Jussi Taipale Laura Campitelli No $#ENSG00000154342#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019 $##ENSG00000154342##Other# FALSE 2738 ENSG00000114251 WNT5A Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None (PMID: 19847889) shows this protein as a part of a large EMSA shifting complex with RNA-Pol1, CHD1, and other DNA binding proteins. It does not, however, show evidence for it binding to DNA directly IPR005817;IPR018161 7474 Wnt family member 5A [Source:HGNC Symbol;Acc:HGNC:12784] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Yimeng Yin Arttu Jolma No $#ENSG00000114251#GO:0003700#sequence-specific DNA binding transcription factor activity#IMP - PMID:19847889$#ENSG00000114251#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IDA - PMID:18287027 $#ENSP00000264634#ENSG00000114251#ENST00000264634#Other#wnt$#ENSP00000418184#ENSG00000114251#ENST00000482079#Other#wnt$#ENSP00000420104#ENSG00000114251#ENST00000497027#Other#wnt FALSE 2739 ENSG00000075290 WNT8B Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None WNT family signaling molecule (PMID: 9536085) IPR005817;IPR013301;IPR018161; 7479 Wnt family member 8B [Source:HGNC Symbol;Acc:HGNC:12789] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Matt Weirauch Laura Campitelli No None $#ENSP00000340677#ENSG00000075290#ENST00000343737#Other#wnt FALSE 2740 ENSG00000165392 WRN Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None ATP dependent DNA helicase. Binds DNA in the crystal structure (PDB: 3AAF) None 7486 Werner syndrome RecQ like helicase 3AAF not tested not tested None None No No No No New proteins added based on PDB entry Arttu Jolma Sam Lambert No None None FALSE 2741 ENSG00000186153 WWOX Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Co-factor of AP-2 (PMID: 15548692) IPR001202;IPR002198;IPR002347 51741 WW domain containing oxidoreductase [Source:HGNC Symbol;Acc:HGNC:12799] None not tested not tested None None No No TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_TF PPI; Transactivation_PMIDS:15548692 No 5a, one of the source datasets predicts is as a TF Pratyush Das Sam Lambert No None $##ENSG00000186153##Other# FALSE 2742 ENSG00000198373 WWP2 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR000008;IPR000569;IPR001202;IPR024928 11060 WW domain containing E3 ubiquitin protein ligase 2 [Source:HGNC Symbol;Acc:HGNC:16804];NEDD4-like E3 None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Pratyush Das Sam Lambert No $#ENSG00000198373#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#ISS - PMID:15047715 $#ENSP00000352069#ENSG00000198373#ENST00000359154#Other#HECT, WW$#ENSP00000348283#ENSG00000198373#ENST00000356003#Other#HECT, WW$#ENSP00000456216#ENSG00000198373#ENST00000568684#Other#HECT, WW FALSE 2743 ENSG00000018408 WWTR1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Transcriptional co-activator that binds to TEADs (PMID: 19324877) and TBX5 (PMID: 16332960) IPR001202 25937 WW domain containing transcription regulator 1 [Source:HGNC Symbol;Acc:HGNC:24042] None not tested not tested None None No No TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:16332960 No 5a, one of the source datasets predicts is as a TF Jussi Taipale Arttu Jolma No None $##ENSG00000018408##Other# FALSE 2744 ENSG00000143184 XCL1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Protein is a secreted chemokine IPR001811;IPR008105 6375 X-C motif chemokine ligand 1 [Source:HGNC Symbol;Acc:HGNC:10645] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Jussi Taipale Arttu Jolma No $#ENSG00000143184#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:10887101 $#ENSP00000356792#ENSG00000143184#ENST00000367818#Other#IL8 FALSE 2745 ENSG00000136936 XPA Unknown Yes Known motif Monomer or homomultimer High-throughput in vitro None Functions in DNA repair (PMID: 19197159), but has a strong HT-SELEX-derived motif. IPR000465;IPR009061;IPR022652;IPR022656;IPR022658; 7507 XPA, DNA damage recognition and repair factor [Source:HGNC Symbol;Acc:HGNC:12814] None Full not tested None None x No No No 1a1, Direct HQ evidence Matt Weirauch Laura Campitelli No None $#ENSP00000364270#ENSG00000136936#ENST00000375128#Other#XPA_C, XPA_N FALSE 2746 ENSG00000163872 YEATS2 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR005033; 55689 YEATS domain containing 2 [Source:HGNC Symbol;Acc:HGNC:25489] None Full not tested None None c No No No 5a, one of the source datasets predicts is as a TF Jussi Taipale Pratyush Das No None $#ENSP00000306983#ENSG00000163872#ENST00000305135#Other#YEATS$#ENSP00000406477#ENSG00000163872#ENST00000432781#Other# FALSE 2747 ENSG00000127337 YEATS4 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Lacks a DBD and the study cited by GO annotation (PMID: 9302258) doesnt have experimental evidence for DNA-binding IPR005033; 8089 YEATS domain containing 4 [Source:HGNC Symbol;Acc:HGNC:24859] None not tested not tested None None x No No Yes 4a, two or more datasets predict it as a TF Sam Lambert Matt Weirauch No $#ENSG00000127337#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:9302258 $#ENSP00000247843#ENSG00000127337#ENST00000247843#Other#SOGA, YEATS$#ENSP00000447199#ENSG00000127337#ENST00000548020#Other#SOGA$#ENSP00000448106#ENSG00000127337#ENST00000549685#Other#YEATS$#ENSP00000446985#ENSG00000127337#ENST00000552955#Other#YEATS FALSE 2748 ENSG00000180667 YOD1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR003323;IPR007087;IPR029071; 55432 YOD1 deubiquitinase [Source:HGNC Symbol;Acc:HGNC:25035] None Full not tested None None x No No No 5a, one of the source datasets predicts is as a TF Sam Lambert Yimeng Yin No None $#ENSP00000326813#ENSG00000180667#ENST00000315927#Other#OTU$#ENSP00000356051#ENSG00000180667#ENST00000367084#Other#OTU FALSE 2749 ENSG00000188707 ZBED6CL Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None No DBDs on UniProt or Ensembl IPR032675 113763 ZBED6 C-terminal like [Source:HGNC Symbol;Acc:HGNC:21720] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Sam Lambert Laura Campitelli No $#ENSG00000188707#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 $#ENSP00000343242#ENSG00000188707#ENST00000343855#Other# FALSE 2750 ENSG00000124256 ZBP1 Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None ZBP1 is structurally-specific for Z-DNA, but does not have any sequence specificity (PDB: 1J75; PMID: 11524677) IPR000607;IPR025735 81030 Z-DNA binding protein 1 [Source:HGNC Symbol;Acc:HGNC:16176] 1J75 Full not tested None None x No No No 1a1, Direct HQ evidence Tim Hughes Sam Lambert No None $#ENSP00000360215#ENSG00000124256#ENST00000371173#Other#z-alpha$#ENSP00000379167#ENSG00000124256#ENST00000395822#Other#z-alpha$#ENSP00000404620#ENSG00000124256#ENST00000453793#Other#$#ENSP00000440552#ENSG00000124256#ENST00000541799#Other#RHIM, z-alpha FALSE 2751 ENSG00000134744 ZCCHC11 Unknown No ssDNA/RNA binding Not a DNA binding protein No motif None Likely a ssDNA or RNA binding protein based on domain composition IPR001878;IPR002058;IPR002934; 23318 zinc finger CCHC-type containing 11 [Source:HGNC Symbol;Acc:HGNC:28981] None Full not tested None None c No No No 5a, one of the source datasets predicts is as a TF Sam Lambert Yimeng Yin No None $#ENSP00000257177#ENSG00000134744#ENST00000257177#Other#NTP_transf_2, PAP_assoc, zf-CCHC, zf-CCHC_2, zf-CC$#ENSP00000348063#ENSG00000134744#ENST00000355809#Other#$#ENSP00000435256#ENSG00000134744#ENST00000484723#Other#NTP_transf_2, PAP_assoc, zf-CCHC$#ENSP00000434367#ENSG00000134744#ENST00000470626#Other#$#ENSP00000434674#ENSG00000134744#ENST00000471623#Other#$#ENSP00000437091#ENSG00000134744#ENST00000494469#Other#$#ENSP00000432475#ENSG00000134744#ENST00000528457#Other#$#ENSP00000435700#ENSG00000134744#ENST00000531722#Other#PAP_assoc, zf-CCHC, zf-CCHC_2, zf-CCHC_4 FALSE 2752 ENSG00000083223 ZCCHC6 Unknown No ssDNA/RNA binding Not a DNA binding protein No motif None (PMID: 23709223) shows that it binds single-stranded nucleid acids IPR001878;IPR002058;IPR003604; 79670 zinc finger CCHC-type containing 6 [Source:HGNC Symbol;Acc:HGNC:25817] None not tested not tested None None c No No No 5a, one of the source datasets predicts is as a TF Sam Lambert Pratyush Das No None $#ENSP00000365127#ENSG00000083223#ENST00000375960#Other#PAP_assoc, TUTF7_u4, tRNA_NucTransf2, zf-CCHC, zf-$#ENSP00000277141#ENSG00000083223#ENST00000277141#Other#NTP_transf_2, PAP_assoc, TUTF7_u4, zf-CCHC, zf-CCH$#ENSP00000365115#ENSG00000083223#ENST00000375948#Other#$#ENSP00000365124#ENSG00000083223#ENST00000375957#Other#PAP_assoc, TSNR_N, TUTF7_u4, zf-CCHC, zf-CCHC_2, z FALSE 2753 ENSG00000188818 ZDHHC11 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None IPR001594; 79844 zinc finger DHHC-type containing 11 [Source:HGNC Symbol;Acc:HGNC:19158] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Pratyush Das Laura Campitelli No None $#ENSP00000283441#ENSG00000188818#ENST00000283441#Other#zf-DHHC$#ENSP00000427067#ENSG00000188818#ENST00000511539#Other#$#ENSP00000426873#ENSG00000188818#ENST00000511193#Other#zf-DHHC$#ENSP00000397719#ENSG00000188818#ENST00000424784#Other# FALSE 2754 ENSG00000163958 ZDHHC19 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None ER transmembrane protein IPR001594; 131540 zinc finger DHHC-type containing 19 [Source:HGNC Symbol;Acc:HGNC:20713] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Jussi Taipale Laura Campitelli No None $#ENSP00000296326#ENSG00000163958#ENST00000296326#Other#zf-DHHC FALSE 2755 ENSG00000146007 ZMAT2 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Possibly an RBP based on presence of a U1 ZF domain IPR003604;IPR022755 153527 zinc finger matrin-type 2 [Source:HGNC Symbol;Acc:HGNC:26433] None Full not tested None None c No No No 5a, one of the source datasets predicts is as a TF Arttu Jolma Matt Weirauch No None $#ENSP00000274712#ENSG00000146007#ENST00000274712#Other#Cgr1, DUF1777, zf-C2H2_jaz, zf-U1, zf-met$#ENSP00000473397#ENSG00000146007#ENST00000519913#Other#zf-C2H2_jaz, zf-U1, zf-met FALSE 2756 ENSG00000123870 ZNF137P Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif Pseudogene Pseudogene None Has no Entrez identifier Putative zinc finger protein 137 None DBD not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Sam Lambert Matt Weirauch Yes $#ENSG00000123870#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:7557990 $##ENSG00000123870##Other# FALSE 2757 ENSG00000147394 ZNF185 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif Has a putative AT-hook Protein has a LIM-subtype ZF. This type of ZF is not likely to bind DNA (PMID: 17696879) None 7739 zinc finger protein 185 None not tested not tested None None No No No No New proteins added after initial stage Arttu Jolma Sam Lambert No None None FALSE 2758 ENSG00000075292 ZNF638 Unknown No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None Binds C-rich dsDNA with low affinity (PMID: 8647861). IPR000504;IPR000690;IPR003604;IPR007087;IPR015880;IPR022755 27332 zinc finger protein 638 [Source:HGNC Symbol;Acc:HGNC:17894] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Arttu Jolma Pratyush Das No None $#ENSP00000264447#ENSG00000075292#ENST00000264447#Other#AKAP95, zf-C2H2_jaz$#ENSP00000386433#ENSG00000075292#ENST00000409544#Other#AKAP95, zf-C2H2_jaz$#ENSP00000485608#ENSG00000075292#ENST00000410075#Other#$#ENSP00000388164#ENSG00000075292#ENST00000437658#Other#$#ENSP00000396909#ENSG00000075292#ENST00000417778#Other#$#ENSP00000409647#ENSG00000075292#ENST00000454122#Other#$#ENSP00000485192#ENSG00000075292#ENST00000461991#Other#zf-C2H2_jaz$#ENSP00000485266#ENSG00000075292#ENST00000464375#Other#$#ENSP00000485494#ENSG00000075292#ENST00000466330#Other#$#ENSP00000485618#ENSG00000075292#ENST00000494621#Other# FALSE 2759 ENSG00000197302 ZNF720 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Contains a KRAB domain (associated with many C2H2 ZFs), but no annotated C2H2 on PDB or UniProt IPR001909;IPR026245 107983990 zinc finger protein 720 [Source:HGNC Symbol;Acc:HGNC:26987] None Full not tested None None c No No No 5a, one of the source datasets predicts is as a TF Sam Lambert Yimeng Yin No None $#ENSP00000319222#ENSG00000197302#ENST00000316491#Other#KRAB$#ENSP00000435171#ENSG00000197302#ENST00000530881#Other#KRAB$#ENSP00000437310#ENSG00000197302#ENST00000529515#Other#KRAB$#ENSP00000431546#ENSG00000197302#ENST00000534369#Other#FRG2$#ENSP00000441893#ENSG00000197302#ENST00000539915#Other# FALSE 2760 ENSG00000172687 ZNF738 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Contains a KRAB domain (associated with many C2H2 ZFs), but no annotated C2H2 on PDB or UniProt IPR001909; 124411 zinc finger protein 738 [Source:HGNC Symbol;Acc:HGNC:32469] None not tested not tested None None x No No No 5a, one of the source datasets predicts is as a TF Jussi Taipale Sam Lambert No None $#ENSP00000311957#ENSG00000172687#ENST00000311015#Other#KRAB$#ENSP00000370252#ENSG00000172687#ENST00000380870#Other#KRAB$#ENSP00000470939#ENSG00000172687#ENST00000594245#Other#$#ENSP00000471336#ENSG00000172687#ENST00000597810#Other#KRAB FALSE 2761 ENSG00000106479 ZNF862 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif Has a putative AT-hook Contains a KRAB domain (associated with many C2H2 ZFs), but no annotated C2H2 on PDB or UniProt None 643641 zinc finger protein 862 None not tested not tested None None No No No No New proteins added after initial stage Arttu Jolma Sam Lambert No None None FALSE 2762 ENSG00000124201 ZNFX1 Unknown No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Probably an RBP (PMID: 22658674; PMID: 22681889) IPR000967;IPR016024;IPR027417; 57169 zinc finger NFX1-type containing 1 [Source:HGNC Symbol;Acc:HGNC:29271] None DBD not tested None None a No No No 5a, one of the source datasets predicts is as a TF Arttu Jolma Matt Weirauch Yes $#ENSG00000124201#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002 $#ENSP00000360819#ENSG00000124201#ENST00000371754#Other#AAA_11, AAA_12, AAA_19, AAA_22, AAA_30, DUF2075, P$#ENSP00000379412#ENSG00000124201#ENST00000396105#Other#AAA_11, AAA_12, AAA_19, AAA_22, AAA_30, DUF2075, R$#ENSP00000360809#ENSG00000124201#ENST00000371744#Other#AAA_11, AAA_19, AAA_30, DUF2075, PhoH, ResIII$#ENSP00000413800#ENSG00000124201#ENST00000455070#Other#AAA_11, AAA_19, AAA_30, DUF2075, PhoH, ResIII, Uvr FALSE 2763 ENSG00000132485 ZRANB2 Unknown No ssDNA/RNA binding Not a DNA binding protein No motif None Its the wrong kind of zinc finger to bind DNA. Likely binds RNA. PMID cited by GO (PMID: 9931435) does not have evidence of sequence-specific DNA binding. IPR001876;IPR017337 9406 zinc finger RANBP2-type containing 2 [Source:HGNC Symbol;Acc:HGNC:13058] None not tested not tested None None No No No Yes 5a, one of the source datasets predicts is as a TF Tim Hughes Matt Weirauch No $#ENSG00000132485#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:9931435 $#ENSP00000254821#ENSG00000132485#ENST00000254821#Other#zf-RanBP$#ENSP00000359958#ENSG00000132485#ENST00000370920#Other#zf-RanBP$#ENSP00000482026#ENSG00000132485#ENST00000611683#Other#zf-RanBP FALSE 2764 ENSG00000107372 ZFAND5 ZZ-type ZF No ssDNA/RNA binding Not a DNA binding protein No motif None An RNA-binding protein that recognises 3UTR located AU-rich elements in mRNA molecules to stabilize them (PMID: 22665488) IPR000058;IPR002653 7763 zinc finger AN1-type containing 5 [Source:HGNC Symbol;Acc:HGNC:13008] None not tested not tested None None No No Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0 No 5a, one of the source datasets predicts is as a TF Arttu Jolma Yimeng Yin No None $##ENSG00000107372##Other# FALSE