Details for gene set BILD_HRAS_ONCOGENIC

Table: GSEA Results Summary

Dataset	NF1_GRD_exprs.NF1_GRD_phenotype.cls #GRD_versus_Ctrl.NF1_GRD_phenotype.cls #GRD_versus_Ctrl_repos
Phenotype	NF1_GRD_phenotype.cls#GRD_versus_Ctrl_repos
Upregulated in class	Ctrl
GeneSet	BILD_HRAS_ONCOGENIC_SIGNATURE
Enrichment Score (ES)	-0.37952545
Normalized Enrichment Score (NES)	-1.761186
Nominal p-value	0.0
FDR q-value	5.3571427E-4
FWER p-Value	0.002

Table: GSEA details [plain text format]
	PROBE	DESCRIPTION (from dataset)	RANK IN GENE LIST	RANK METRIC SCORE	RUNNING ES	CORE ENRICHMENT
1	VEGFA	VEGFA	2	0.280	0.0259	No
2	SLC16A3	SLC16A3	31	0.173	0.0407	No
3	FLNB	FLNB	64	0.143	0.0524	No
4	KLF6	KLF6	97	0.128	0.0629	No
5	STAG3L1	STAG3L1	103	0.125	0.0742	No
6	FOS	FOS	104	0.125	0.0858	No
7	TPM1	TPM1	120	0.116	0.0958	No
8	ZNF608	ZNF608	125	0.113	0.1061	No
9	HNRNPH1	HNRNPH1	173	0.104	0.1136	No
10	MEG3	MEG3	268	0.093	0.1178	No
11	CCNL1	CCNL1	269	0.093	0.1264	No
12	EPHA4	EPHA4	356	0.086	0.1303	No
13	NAMPT	NAMPT	433	0.081	0.1343	No
14	PPP1R15A	PPP1R15A	477	0.079	0.1396	No
15	KLF5	KLF5	486	0.078	0.1465	No
16	ZNF827	ZNF827	564	0.074	0.1498	No
17	UPP1	UPP1	694	0.070	0.1502	No
18	DUSP4	DUSP4	727	0.068	0.1550	No
19	GLTP	GLTP	801	0.066	0.1577	No
20	SLC2A3	SLC2A3	977	0.061	0.1552	No
21	SOCS1	SOCS1	1015	0.060	0.1590	No
22	PALMD	PALMD	1113	0.058	0.1599	No
23	ANGPTL4	ANGPTL4	1289	0.055	0.1568	No
24	PVR	PVR	1393	0.053	0.1569	No
25	AKAP12	AKAP12	1567	0.050	0.1534	No
26	CASP2	CASP2	1608	0.050	0.1562	No
27	JUNB	JUNB	1660	0.049	0.1583	No
28	TIA1	TIA1	1816	0.047	0.1554	No
29	VANGL2	VANGL2	1851	0.046	0.1581	No
30	ARHGEF9	ARHGEF9	1905	0.046	0.1599	No
31	BCL6	BCL6	1952	0.045	0.1619	No
32	SEMA4B	SEMA4B	2149	0.043	0.1568	No
33	MID1	MID1	2162	0.043	0.1602	No
34	HIST1H2AC	HIST1H2AC	2186	0.043	0.1630	No
35	C6orf141	C6orf141	2212	0.042	0.1658	No
36	LRIG3	LRIG3	2227	0.042	0.1690	No
37	MALAT1	MALAT1	2253	0.042	0.1717	No
38	NOLC1	NOLC1	2279	0.041	0.1744	No
39	TBX3	TBX3	2301	0.041	0.1773	No
40	DDX17	DDX17	2679	0.038	0.1631	No
41	HOXC6	HOXC6	2789	0.037	0.1614	No
42	XIST	XIST	2824	0.037	0.1632	No
43	CCNA1	CCNA1	3075	0.035	0.1548	No
44	PTX3	PTX3	3107	0.034	0.1565	No
45	MLL3	MLL3	3206	0.034	0.1550	No
46	ITGA2	ITGA2	3297	0.033	0.1539	No
47	RRP9	RRP9	3751	0.030	0.1354	No
48	OXSR1	OXSR1	3867	0.029	0.1327	No
49	MYD88	MYD88	3892	0.029	0.1343	No
50	ST5	ST5	4088	0.028	0.1277	No
51	ELOVL7	ELOVL7	4111	0.028	0.1292	No
52	NIPAL1	NIPAL1	4192	0.027	0.1280	No
53	ADRB2	ADRB2	4272	0.027	0.1268	No
54	KIAA0528	KIAA0528	4366	0.026	0.1248	No
55	HIST1H1E	HIST1H1E	4382	0.026	0.1265	No
56	GLCCI1	GLCCI1	4470	0.025	0.1248	No
57	TNFRSF10A	TNFRSF10A	4553	0.025	0.1233	No
58	NFIB	NFIB	4586	0.025	0.1241	No
59	ZFP36	ZFP36	4748	0.024	0.1188	No
60	HRAS	HRAS	4781	0.024	0.1195	No
61	TGFA	TGFA	4900	0.023	0.1161	No
62	PNLIPRP3	PNLIPRP3	5025	0.022	0.1123	No
63	DNAJC6	DNAJC6	5289	0.021	0.1020	No
64	ELK3	ELK3	5298	0.021	0.1035	No
65	MTPAP	MTPAP	5314	0.021	0.1048	No
66	PNMA2	PNMA2	5558	0.020	0.0952	No
67	ITPR3	ITPR3	5808	0.019	0.0853	No
68	RNF152	RNF152	5951	0.018	0.0803	No
69	TNRC6A	TNRC6A	5993	0.018	0.0800	No
70	ZBED2	ZBED2	6053	0.017	0.0789	No
71	SERPINB2	SERPINB2	6290	0.016	0.0694	No
72	CSNK1E	CSNK1E	6457	0.016	0.0630	No
73	EFNB1	EFNB1	6468	0.016	0.0640	No
74	MBOAT2	MBOAT2	6497	0.016	0.0642	No
75	MED25	MED25	6554	0.015	0.0630	No
76	MAST4	MAST4	6641	0.015	0.0603	No
77	TMTC3	TMTC3	6826	0.014	0.0530	No
78	LRAT	LRAT	6935	0.014	0.0492	No
79	KCNK1	KCNK1	7034	0.013	0.0459	No
80	NAV3	NAV3	7054	0.013	0.0462	No
81	LYN	LYN	7132	0.013	0.0438	No
82	FN1	FN1	7138	0.013	0.0448	No
83	HK2	HK2	7149	0.013	0.0455	No
84	SERPINB1	SERPINB1	7384	0.012	0.0356	No
85	TOR1AIP1	TOR1AIP1	7699	0.011	0.0219	No
86	FOXQ1	FOXQ1	7982	0.010	0.0096	No
87	IL8	IL8	8099	0.009	0.0050	No
88	KDM6B	KDM6B	8195	0.009	0.0014	No
89	CALM2	CALM2	8218	0.009	0.0012	No
90	TOB1	TOB1	8531	0.008	-0.0127	No
91	TTC8	TTC8	8582	0.008	-0.0144	No
92	TOP1	TOP1	8831	0.007	-0.0254	No
93	PIM1	PIM1	8834	0.006	-0.0249	No
94	DUSP1	DUSP1	8850	0.006	-0.0250	No
95	SFN	SFN	8909	0.006	-0.0271	No
96	ACOT7	ACOT7	9041	0.006	-0.0327	No
97	PDGFA	PDGFA	9046	0.006	-0.0323	No
98	GJB3	GJB3	9178	0.005	-0.0380	No
99	CSNK1D	CSNK1D	9324	0.005	-0.0443	No
100	CDCP1	CDCP1	9398	0.005	-0.0473	No
101	IRX2	IRX2	9631	0.004	-0.0579	No
102	ADAMTS5	ADAMTS5	9676	0.003	-0.0596	No
103	SERPINB3	SERPINB3	9711	0.003	-0.0609	No
104	ZNF192	ZNF192	9786	0.003	-0.0641	No
105	SPRY4	SPRY4	9820	0.003	-0.0654	No
106	PIAS1	PIAS1	9931	0.003	-0.0703	No
107	IER2	IER2	10164	0.002	-0.0810	No
108	SAMD8	SAMD8	10199	0.002	-0.0824	No
109	KCNN4	KCNN4	10334	0.001	-0.0886	No
110	LGALS8	LGALS8	10438	0.001	-0.0933	No
111	COL27A1	COL27A1	10591	0.000	-0.1004	No
112	ABCA1	ABCA1	10676	-0.000	-0.1044	No
113	NFKBIZ	NFKBIZ	10728	-0.000	-0.1067	No
114	PRNP	PRNP	10742	-0.000	-0.1073	No
115	TNFRSF10B	TNFRSF10B	10856	-0.001	-0.1126	No
116	G0S2	G0S2	11140	-0.002	-0.1257	No
117	ZNF862	ZNF862	11180	-0.002	-0.1273	No
118	C7orf49	C7orf49	11287	-0.002	-0.1321	No
119	SLC6A15	SLC6A15	11397	-0.003	-0.1370	No
120	RUNX1	RUNX1	11533	-0.003	-0.1430	No
121	MBNL2	MBNL2	11583	-0.003	-0.1450	No
122	MDH1	MDH1	11609	-0.003	-0.1459	No
123	LAMA3	LAMA3	11880	-0.004	-0.1581	No
124	HPSE	HPSE	11998	-0.005	-0.1632	No
125	PIK3CD	PIK3CD	12129	-0.005	-0.1688	No
126	DLST	DLST	12217	-0.005	-0.1724	No
127	LRRFIP1	LRRFIP1	12234	-0.005	-0.1726	No
128	CXCL3	CXCL3	12327	-0.006	-0.1764	No
129	ADAM8	ADAM8	12370	-0.006	-0.1778	No
130	KANK4	KANK4	12488	-0.006	-0.1827	No
131	MRGPRX3	MRGPRX3	12492	-0.006	-0.1822	No
132	ULBP2	ULBP2	12567	-0.007	-0.1851	No
133	CCL20	CCL20	12611	-0.007	-0.1864	No
134	LRRC8C	LRRC8C	12614	-0.007	-0.1859	No
135	PHACTR4	PHACTR4	12711	-0.007	-0.1897	No
136	DLL1	DLL1	12760	-0.007	-0.1913	No
137	FGFR2	FGFR2	12843	-0.008	-0.1944	No
138	LATS1	LATS1	12911	-0.008	-0.1968	No
139	CXCL5	CXCL5	12926	-0.008	-0.1968	No
140	PTGS2	PTGS2	13295	-0.009	-0.2131	No
141	PPBP	PPBP	13429	-0.010	-0.2185	No
142	ZNF273	ZNF273	13509	-0.010	-0.2212	No
143	FERMT1	FERMT1	13596	-0.010	-0.2243	No
144	GRHL2	GRHL2	13723	-0.011	-0.2292	No
145	ARG2	ARG2	13796	-0.011	-0.2315	No
146	PI3	PI3	13838	-0.011	-0.2324	No
147	TNRC6B	TNRC6B	13850	-0.011	-0.2318	No
148	DUSP6	DUSP6	13939	-0.012	-0.2348	No
149	TMEM45B	TMEM45B	13977	-0.012	-0.2355	No
150	EGR1	EGR1	13994	-0.012	-0.2351	No
151	MFAP2	MFAP2	14033	-0.012	-0.2358	No
152	MTUS1	MTUS1	14054	-0.012	-0.2356	No
153	GJB5	GJB5	14317	-0.013	-0.2466	No
154	DENND2C	DENND2C	14350	-0.013	-0.2469	No
155	SERPINB5	SERPINB5	14570	-0.014	-0.2558	No
156	RAPH1	RAPH1	14606	-0.014	-0.2561	No
157	FAM46B	FAM46B	14624	-0.014	-0.2556	No
158	CD274	CD274	14837	-0.015	-0.2641	No
159	CD55	CD55	15072	-0.016	-0.2735	No
160	ARHGAP25	ARHGAP25	15330	-0.017	-0.2839	No
161	MXD1	MXD1	15619	-0.019	-0.2957	No
162	FAM110C	FAM110C	15623	-0.019	-0.2941	No
163	FGFBP1	FGFBP1	15926	-0.020	-0.3064	No
164	FAM83A	FAM83A	16193	-0.021	-0.3169	No
165	HMGN3	HMGN3	16251	-0.022	-0.3175	No
166	COL12A1	COL12A1	16288	-0.022	-0.3172	No
167	B3GNT5	B3GNT5	16407	-0.022	-0.3206	No
168	INPP1	INPP1	16488	-0.023	-0.3223	No
169	MAP1LC3B	MAP1LC3B	16801	-0.024	-0.3346	No
170	TNS4	TNS4	16815	-0.024	-0.3330	No
171	FLRT3	FLRT3	16911	-0.025	-0.3351	No
172	TCF7L2	TCF7L2	16950	-0.025	-0.3346	No
173	ODC1	ODC1	17173	-0.026	-0.3426	No
174	CHST11	CHST11	17182	-0.026	-0.3405	No
175	EREG	EREG	17229	-0.027	-0.3402	No
176	LPAR2	LPAR2	17240	-0.027	-0.3382	No
177	ARHGAP27	ARHGAP27	17251	-0.027	-0.3362	No
178	PNPLA8	PNPLA8	17433	-0.028	-0.3421	No
179	MALL	MALL	17453	-0.028	-0.3404	No
180	JHDM1D	JHDM1D	17469	-0.028	-0.3385	No
181	FBXO9	FBXO9	17493	-0.028	-0.3370	No
182	MCL1	MCL1	17541	-0.028	-0.3366	No
183	ADAMTS15	ADAMTS15	17590	-0.029	-0.3362	No
184	CASP1	CASP1	17665	-0.029	-0.3370	No
185	SEMA4C	SEMA4C	17714	-0.029	-0.3365	No
186	SH2D5	SH2D5	17771	-0.029	-0.3364	No
187	SMTN	SMTN	17798	-0.030	-0.3348	No
188	CXCL2	CXCL2	17851	-0.030	-0.3345	No
189	SRRM2	SRRM2	17926	-0.030	-0.3351	No
190	C19orf10	C19orf10	17951	-0.031	-0.3334	No
191	EHD1	EHD1	18030	-0.031	-0.3342	No
192	CYP27B1	CYP27B1	18214	-0.032	-0.3398	No
193	TGFB2	TGFB2	18238	-0.033	-0.3378	No
194	PHLDA1	PHLDA1	18279	-0.033	-0.3366	No
195	CYP2R1	CYP2R1	18322	-0.033	-0.3355	No
196	PTPRE	PTPRE	18369	-0.033	-0.3346	No
197	PLXNA2	PLXNA2	18553	-0.035	-0.3399	No
198	CALU	CALU	18621	-0.035	-0.3398	No
199	IL13RA2	IL13RA2	18711	-0.036	-0.3406	No
200	SDC1	SDC1	18831	-0.037	-0.3427	No
201	BMP2	BMP2	18843	-0.037	-0.3398	No
202	UAP1	UAP1	18886	-0.038	-0.3382	No
203	STX1A	STX1A	19143	-0.040	-0.3465	No
204	MAP7D1	MAP7D1	19340	-0.042	-0.3518	No
205	PLAUR	PLAUR	19606	-0.045	-0.3601	No
206	LHFPL2	LHFPL2	19740	-0.046	-0.3620	No
207	GK	GK	20062	-0.051	-0.3724	No
208	CXCL1	CXCL1	20079	-0.051	-0.3684	No
209	TRIM22	TRIM22	20318	-0.055	-0.3744	Yes
210	TSC22D1	TSC22D1	20383	-0.056	-0.3722	Yes
211	GAS1	GAS1	20486	-0.058	-0.3716	Yes
212	CYP1B1	CYP1B1	20518	-0.059	-0.3677	Yes
213	SKP2	SKP2	20596	-0.060	-0.3657	Yes
214	TFPI2	TFPI2	20632	-0.062	-0.3616	Yes
215	B4GALT1	B4GALT1	20633	-0.062	-0.3559	Yes
216	PPIF	PPIF	20717	-0.064	-0.3538	Yes
217	SLC25A37	SLC25A37	20764	-0.065	-0.3499	Yes
218	TUBA4A	TUBA4A	20809	-0.067	-0.3458	Yes
219	S100A6	S100A6	20850	-0.068	-0.3414	Yes
220	ARNTL2	ARNTL2	20855	-0.068	-0.3353	Yes
221	ATP2B1	ATP2B1	20901	-0.069	-0.3310	Yes
222	MMP14	MMP14	20926	-0.070	-0.3256	Yes
223	TIMP1	TIMP1	21029	-0.074	-0.3235	Yes
224	LRP8	LRP8	21057	-0.075	-0.3178	Yes
225	GTPBP2	GTPBP2	21111	-0.078	-0.3131	Yes
226	PHLDA2	PHLDA2	21151	-0.080	-0.3075	Yes
227	SLC20A1	SLC20A1	21191	-0.083	-0.3017	Yes
228	SLC9A1	SLC9A1	21248	-0.087	-0.2963	Yes
229	ITPRIP	ITPRIP	21293	-0.090	-0.2900	Yes
230	EPHA2	EPHA2	21313	-0.092	-0.2823	Yes
231	HBEGF	HBEGF	21345	-0.097	-0.2748	Yes
232	LIF	LIF	21404	-0.105	-0.2677	Yes
233	LDLR	LDLR	21410	-0.105	-0.2582	Yes
234	SESN2	SESN2	21424	-0.107	-0.2489	Yes
235	NT5E	NT5E	21448	-0.112	-0.2395	Yes
236	IL1A	IL1A	21453	-0.113	-0.2292	Yes
237	IER3	IER3	21480	-0.122	-0.2191	Yes
238	SDC4	SDC4	21489	-0.125	-0.2079	Yes
239	IL1B	IL1B	21493	-0.129	-0.1961	Yes
240	CLCF1	CLCF1	21517	-0.146	-0.1837	Yes
241	AHNAK2	AHNAK2	21523	-0.148	-0.1702	Yes
242	NDRG1	NDRG1	21524	-0.149	-0.1563	Yes
243	TNFRSF12A	TNFRSF12A	21534	-0.154	-0.1425	Yes
244	FOSL1	FOSL1	21546	-0.167	-0.1275	Yes
245	TRIB1	TRIB1	21555	-0.173	-0.1118	Yes
246	PTHLH	PTHLH	21558	-0.176	-0.0955	Yes
247	IL11	IL11	21567	-0.185	-0.0787	Yes
248	AGPAT9	AGPAT9	21568	-0.188	-0.0613	Yes
249	TMEM154	TMEM154	21569	-0.190	-0.0437	Yes
250	DUSP5	DUSP5	21581	-0.219	-0.0238	Yes
251	GDF15	GDF15	21592	-0.263	0.0001	Yes